Ping-Kang Chen, Zhong-Yuan Cheng, Ya-Lin Wang, Bao-Jun Xu, Zong-Chao Yu, Zhao-Xia Li, Shang-Ao Gong, Feng-Tao Zhang, Long Qian, Wei Cui, You-Zhen Feng, Xiang-Ran Cai
BACKGROUND: To investigate the feasibility of Diffusion Kurtosis Imaging (DKI) in assessing renal interstitial fibrosis induced by hyperuricemia. METHODS: A hyperuricemia rat model was established, and the rats were randomly split into the hyperuricemia (HUA), allopurinol (AP), and AP + empagliflozin (AP + EM) groups (n = 19 per group). Also, the normal rats were selected as controls (CON, n = 19). DKI was performed before treatment (baseline) and on days 1, 3, 5, 7, and 9 days after treatment...
April 3, 2024: BMC Medical Imaging