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BMC Infectious Diseases

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https://www.readbyqxmd.com/read/28330443/influenza-and-respiratory-syncytial-virus-in-infants-study-iris-of-hospitalized-and-non-ill-infants-aged-1-year-in-four-countries-study-design-and-methods
#1
Mark G Thompson, Danielle R Hunt, Ali K Arbaji, Artan Simaku, Veronica L Tallo, Holly M Biggs, Carolyn Kulb, Aubree Gordon, Ilham Abu Khader, Silvia Bino, Marilla G Lucero, Eduardo Azziz-Baumgartner, Pat Shifflett, Felix Sanchez, Basima I Marar, Ilirjana Bakalli, Eric A F Simões, Min Z Levine, Jennifer K Meece, Angel Balmaseda, Tareq M Al-Sanouri, Majlinda Dhimolea, Joanne N de Jesus, Natalie J Thornburg, Susan I Gerber, Lionel Gresh
BACKGROUND: This multi-country prospective study of infants aged <1 year aims to assess the frequency of influenza virus and respiratory syncytial virus (RSV) infections associated with hospitalizations, to describe clinical features and antibody response to infection, and to examine predictors of very severe disease requiring intensive care. METHODS/DESIGN: We are enrolling a hospital-based cohort and a sample of non-ill infants in four countries (Albania, Jordan, Nicaragua, and the Philippines) using a common protocol...
March 22, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28327099/differential-cytokine-profiling-in-chagasic-patients-according-to-their-arrhythmogenic-status
#2
Héctor Rodríguez-Angulo, Juan Marques, Ivan Mendoza, Marco Villegas, Alfredo Mijares, Núria Gironès, Manuel Fresno
BACKGROUND: Chagas disease is caused by the protozoan Trypanosoma cruzi and is characterized by heart failure and sudden death. Identifying which factors are involved in evolution and treatment response is actually challenging. Thus, the aim of this work was to determine the Th1/Th17 (IL-6, IL-2, TNF, IL-17 and IFN-γ) and Th2 (IL-4 and IL-10) serum profile in Venezuelan Chagasic patients stratified according amiodarone treatment, hypertension and arrhythmias. METHODS: Sera from 38 chagasic patients were analyzed to determine the level of cytokines by Multiplexed Bead-Based Immunoassays...
March 21, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28320319/cytomegalovirus-epstein-barr-virus-and-varicella-zoster-virus-infection-in-the-first-two-years-of-life-a-cohort-study-in-bradford-uk
#3
Lucy Pembrey, Dagmar Waiblinger, Paul Griffiths, Mauli Patel, Rafaq Azad, John Wright
BACKGROUND: Cytomegalovirus (CMV), Epstein Barr virus (EBV) and varicella-zoster virus (VZV) are common herpesviruses frequently acquired in childhood, which establish persistent, latent infection and are likely to impact the developing immune system. Little is known about the epidemiology of CMV and EBV infections in contemporary UK paediatric populations, particularly whether age at infection differs by ethnic group. METHODS: Children enrolled in the Born in Bradford Allergy and Infection Study had a blood sample taken and a questionnaire completed at 12 and 24 months of age...
March 21, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28320341/seasonal-patterns-of-dengue-fever-and-associated-climate-factors-in-4-provinces-in-vietnam-from-1994-to-2013
#4
Hu Suk Lee, Hung Nguyen-Viet, Vu Sinh Nam, Mihye Lee, Sungho Won, Phuc Pham Duc, Delia Grace
BACKGROUND: In Vietnam, dengue fever (DF) is still a leading cause of hospitalization. The main objective of this study was to evaluate the seasonality and association with climate factors (temperature and precipitation) on the incidences of DF in four provinces where the highest incidence rates were observed from 1994 to 2013 in Vietnam. METHODS: Incidence rates (per 100,000) were calculated on a monthly basis from during the study period. The seasonal-decomposition procedure based on loess (STL) was used in order to assess the trend and seasonality of DF...
March 20, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28320336/multidrug-resistant-tuberculosis-in-ethiopian-settings-and-its-association-with-previous-history-of-anti-tuberculosis-treatment-a-systematic-review-and-meta-analysis
#5
Setegn Eshetie, Mucheye Gizachew, Mulat Dagnew, Gemechu Kumera, Haile Woldie, Fekadu Ambaw, Belay Tessema, Feleke Moges
BACKGROUND: Efforts to control the global burden of tuberculosis (TB) have been jeopardized by the rapid evolution of multi-drug resistant Mycobacterium tuberculosis (MTB), which is resistant to at least isoniazid and rifampicin. Previous studies have documented variable prevalences of multidrug-resistant tuberculosis (MDR-TB) and its risk factors in Ethiopia. Therefore, this meta-analysis is aimed, firstly, to determine the pooled prevalence of MDR-TB among newly diagnosed and previously treated TB cases, and secondly, to measure the association between MDR-TB and a history of previous anti-TB drugs treatment...
March 20, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28320320/antiviral-activity-of-pha767491-against-human-herpes-simplex-virus-in-vitro-and-in-vivo
#6
Jue Hou, Zili Zhang, Qiang Huang, Jun Yan, Xiaohu Zhang, Xiaoliang Yu, Guihua Tan, Chunfu Zheng, Feng Xu, Sudan He
BACKGROUND: Herpes simplex virus (HSV) is a common human pathogen that causes a variety of diseases, including oral-labial, genital lesions and life-threatening encephalitis. The antiviral nucleoside analogues such as acyclovir are currently used in anti-HSV therapies; however, clinical overuse of these drugs has led to the emergence of drug-resistant viral strains. Hence, there is an urgent need to develop new anti-HSV agents. METHODS: To identify novel anti-HSV-1 compounds, we screened the LOPAC small scale library of 1280 bioactive compounds to identify inhibitors of HSV-1-induced necroptosis...
March 20, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28302072/imported-arboviral-infections-in-italy-july-2014-october-2015-a-national-reference-laboratory-report
#7
Claudia Fortuna, Maria Elena Remoli, Caterina Rizzo, Eleonora Benedetti, Cristiano Fiorentini, Antonino Bella, Claudio Argentini, Francesca Farchi, Concetta Castilletti, Maria Rosaria Capobianchi, Lorenzo Zammarchi, Alessandro Bartoloni, Nadia Zanchetta, Maria Rita Gismondo, Luca Ceccherini Nelli, Giustina Vitale, Franco Baldelli, Pierlanfranco D'Agaro, Giuseppe Sodano, Giovanni Rezza, Giulietta Venturi
BACKGROUND: Imported cases of infections due to Dengue (DENV) and Chikungunya (CHIKV) viruses and, more recently, Zika virus (ZIKV) are commonly reported among travelers returning from endemic regions. In areas where potentially competent vectors are present, the risk of autochthonous transmission of these vector-borne pathogens is relatively high. Laboratory surveillance is crucial to rapidly detect imported cases in order to reduce the risk of transmission. This study describes the laboratory activity performed by the National Reference Laboratory for Arboviruses (NRLA) at the Italian National Institute of Health in the period from July 2014 to October 2015...
March 16, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28302070/prevalence-and-incidence-of-smear-positive-pulmonary-tuberculosis-in-the-hetosa-district-of-arsi-zone-oromia-regional-state-of-central-ethiopia
#8
ShalloDaba Hamusse, Meaza Demissie, Dejene Teshome, Mohammed Suaudi Hassen, Bernt Lindtjørn
BACKGROUND: The real burden of smear-positive (PTB+) and bacteriologically confirmed tuberculosis (BCTB) in Ethiopia is not known. Thus, the aim of this community-based study was to measure the prevalence and incidence of tuberculosis in the Hetosa District of Oromia Region, Ethiopia. METHODS: First, a population-based cross-sectional survey was conducted on a total of 33,073 individuals aged ≥ 15 years to determine the prevalence of PTB+ and BCTB cases. Then, in order to determine the incidence, a prospective follow-up was carried out on 32,800 individuals found to be either free from symptoms suggestive of TB (SSTB) during the baseline survey or had symptoms suggestive of TB but yielded negative bacteriological examination results...
March 16, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28302065/lamivudine-dolutegravir-dual-therapy-in-hiv-infected-virologically-suppressed-patients
#9
Franco Maggiolo, Roberto Gulminetti, Layla Pagnucco, Margherita Digaetano, Simone Benatti, Daniela Valenti, Annapaola Callegaro, Diego Ripamonti, Cristina Mussini
BACKGROUND: Little is known about the applicability of dual treatments based on integrase inhibitors. We explored the combination of lamivudine + dolutegravir as an option when switching from standard cART in virologically suppressed patients. METHODS: In this prospective cohort we enrolled patients previously switched to 3TC + DTG who were 18 years or older, with no previous resistance mutations to the used drugs, having a HIV-RNA <50 copies/ml for 6 months or longer, negative for HBsAg and on a stable (>6 months) cART...
March 16, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28298208/looking-back-to-move-forward-a-twenty-year-audit-of-herpes-zoster-in-asia-pacific
#10
REVIEW
Liang-Kung Chen, Hidenori Arai, Liang-Yu Chen, Ming-Yueh Chou, Samsuridjal Djauzi, Birong Dong, Taro Kojima, Ki Tae Kwon, Hoe Nam Leong, Edward M F Leung, Chih-Kuang Liang, Xiaohong Liu, Dilip Mathai, Jiun Yit Pan, Li-Ning Peng, Eduardo Rommel S Poblete, Philip J H Poi, Stewart Reid, Terapong Tantawichien, Chang Won Won
BACKGROUND: Herpes zoster (HZ) is a prevalent viral disease that inflicts substantial morbidity and associated healthcare and socioeconomic burdens. Current treatments are not fully effective, especially among the most vulnerable patients. Although widely recommended, vaccination against HZ is not routine; barriers in Asia-Pacific include long-standing neglect of adult immunisation and sparse local data. To address knowledge gaps, raise awareness, and disseminate best practice, we reviewed recent data and guidelines on HZ from the Asia-Pacific region...
March 15, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28298206/burden-and-spectrum-of-bacterial-infections-among-sickle-cell-disease-children-living-in-cameroon
#11
Anastasie Nicole Alima Yanda, Jobert Richie N Nansseu, Hubert Désiré Mbassi Awa, Sandra A Tatah, Judith Seungue, Charlotte Eposse, Paul Olivier N Koki
BACKGROUND: Although sickle cell disease (SCD) children are highly susceptible to bacterial infections (BIs), there is a dreadful lack of data related to the burden and spectrum of BIs in sub-Saharan Africa (SSA), the highest affected region with SCD. This study aimed to determine the burden and spectrum of BIs among SCD children hospitalized in a pediatric reference hospital in Cameroon, a SSA country. METHODS: We conducted a retrospective analysis of records of children hospitalized from November 2012 to August 2015 in the SCD unit of the Mother and Child Centre of the Chantal Biya Foundation, Cameroon...
March 15, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28298195/role-of-systemic-inflammation-scores-for-prediction-of-clinical-outcomes-in-patients-treated-with-atazanavir-not-boosted-by-ritonavir-in-the-italian-master-cohort
#12
Maria Concetta Postorino, Mattia Prosperi, Emanuele Focà, Eugenia Quiros-Roldan, Elisa Di Filippo, Franco Maggiolo, Alberto Borghetti, Nicoletta Ladisa, Massimo Di Pietro, Andrea Gori, Laura Sighinolfi, Angelo Pan, Nicola Mazzini, Carlo Torti
BACKGROUND: Atazanavir (ATV) not boosted by ritonavir (uATV) has been frequently used in the past for switching combination antiretroviral therapy (cART). However, the clinical outcomes and predictors of such strategy are unknown. METHODS: An observational study was carried out on the Italian MASTER, selecting HIV infected patients on cART switching to an uATV-containing regimen. Baseline was set as the last visit before uATV initiation. In the primary analysis, a composite clinical end-point was defined as the first occurring of any condition among: liver, cardiovascular, kidney, diabetes, non AIDS related cancer or death events...
March 15, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28298186/association-of-mannose-binding-lectin-gene-polymorphisms-with-the-development-of-pulmonary-tuberculosis-in-china
#13
Yan-Ling Guo, Yang Liu, Wu-Juan Ban, Qi Sun, Guang-Li Shi
BACKGROUND: Mannose-binding lectin (MBL) is an important protein in the lectin pathway of the immune system. This study explores the association between MBL polymorphism and the susceptibility to tuberculosis (TB). The association between the MBL2 polymorphisms and serum MBL levels is also analyzed in the present study. METHODS: A total of 112 inpatients with pulmonary TB and 120 healthy controls were recruited to participate in this case-control study. Polymerase Chain Reaction-Restriction Fragment Length Polymorphism(PCR-RFLP) technology was used to genotype MBL gene (variants in -221Y/X and exon l codons 54 A/B)...
March 15, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28292284/is-bulpa-criteria-suitable-for-the-diagnosis-of-probable-invasive-pulmonary-aspergillosis-in-critically-ill-patients-with-chronic-obstructive-pulmonary-disease-a-comparative-study-with-eortc-msg-and-icu-criteria
#14
Linna Huang, Hangyong He, Jingjing Jin, Qingyuan Zhan
BACKGROUND: Three diagnostic criteria have been proposed used for invasive pulmonary aspergillosis (IPA) diagnosis, namely EORTC/ MSG criteria, Bulpa criteria and intensive care unit (ICU) criteria. The Bulpa criteria were proposed to diagnose IPA in chronic obstructive pulmonary disease (COPD) patients specially. Our aim is to verify that whether the Bulpa criteria are the most suitable for diagnosing probable IPA in critically ill COPD patients compared with the other two criteria. METHODS: We included critically ill COPD patients admitted to the ICU from April 2006 to August 2013...
March 14, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28292280/the-impact-of-community-acquired-pneumonia-on-the-health-related-quality-of-life-in-elderly
#15
Marie-Josée J Mangen, Susanne M Huijts, Marc J M Bonten, G Ardine de Wit
BACKGROUND: The sustained health-related quality-of-life of patients surviving community-acquired pneumonia has not been accurately quantified. The aim of the current study was to quantify differences in health-related quality-of-life of community-dwelling elderly with and without community-acquired pneumonia during a 12-month follow-up period. METHODS: In a matched cohort study design, nested in a prospective randomized double-blind placebo-controlled trial on the efficacy of the 13-valent pneumococcal vaccine in community-dwelling persons of ≥65 years, health-related quality-of-life was assessed in 562 subjects hospitalized with suspected community-acquired pneumonia (i...
March 14, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28292273/ocular-bacterial-infections-at-quiha-ophthalmic-hospital-northern-ethiopia-an-evaluation-according-to-the-risk-factors-and-the-antimicrobial-susceptibility-of-bacterial-isolates
#16
Mebrahtu Teweldemedhin, Muthupandian Saravanan, Araya Gebreyesus, Dawit Gebreegziabiher
BACKGROUND: External and intraocular infections can lead to visual impairments, which is a major public health problem. Bacteria are the most frequent pathogens affecting ocular structures; the increasing rate of antimicrobial drug resistance is a worldwide concern. The aim of this study was to determine the occurrence of bacteria in ocular infections, their antimicrobial susceptibility patterns, and risk factors in bacterial ocular infection. METHODS: A hospital based cross-sectional study was conducted from September 2015 to December 2015 at Quiha Ophthalmic Hospital, Tigray, northern Ethiopia...
March 14, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28288577/elevated-prevalence-of-multidrug-resistant-gram-negative-organisms-in-hiv-positive-men
#17
Claudia Reinheimer, Oliver T Keppler, Christoph Stephan, Thomas A Wichelhaus, Imke Friedrichs, Volkhard A J Kempf
BACKGROUND: Routes of transmission of multidrug-resistant gram-negative organisms (MDRGN) are not completely understood. Since sexual transmission of MDRGN might represent a potential mode that has not been noticed so far, this study evaluated transmission of MDRGN in HIV positive men. METHODS: Between November 2014 and March 2016, we retrospectively investigated the MDRGN prevalence in rectal swabs of n = 109 males tested positive for HIV (HP). These findings were compared to the MDRGN prevalence in n = 109 rectal swabs in age-matched males tested negative for HIV (HN) within the same period...
March 13, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28284209/increased-sensitivity-of-ns1-elisa-by-heat-dissociation-in-acute-dengue-4-cases
#18
Sibelle Nogueira Buonora, Flavia Barreto Dos Santos, Regina Paiva Daumas, Sonia Regina Lambert Passos, Manoela Heringer da Silva, Monique Rocha de Lima, Rita Maria Ribeiro Nogueira
BACKGROUND: Dengue is an acute febrile illness considered the major arboviral disease in terms of morbidity, mortality, economic impact and dissemination worldwide. Brazil accounts for the highest notification rate, with circulation of all four dengue serotypes. The NS1 antigen is a dengue highly conserved specific soluble glycoprotein essential for viral replication and viability that can be detected 0 to 18 days from the onset of fever (peak first 3 days). It induces a strong humoral response and is known as a complement-fixing antigen...
March 11, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28284196/burden-of-bloodstream-infection-in-an-area-of-mid-norway-2002-2013-a-prospective-population-based-observational-study
#19
Arne Mehl, Bjørn Olav Åsvold, Stian Lydersen, Julie Paulsen, Erik Solligård, Jan Kristian Damås, Stig Harthug, Tom-Harald Edna
BACKGROUND: Studies from several countries indicate that the incidence and mortality of bloodstream infection (BSI) have been increasing over time. METHODS: We studied the burden of disease and death related to BSI in a defined geographical area of Mid-Norway, where BSI episodes were prospectively recorded by the same microbiological department during 12 consecutive years. Death from BSI was defined as death within 30 days of BSI detection. Age and sex standardized incidence and mortality rates and case fatality rates were calculated...
March 11, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28283020/carbapenem-resistant-klebsiella-pneumoniae-in-high-risk-haematological-patients-factors-favouring-spread-risk-factors-and-outcome-of-carbapenem-resistant-klebsiella-pneumoniae-bacteremias
#20
Alessandra Micozzi, Giuseppe Gentile, Clara Minotti, Claudio Cartoni, Saveria Capria, Daniele Ballarò, Stefania Santilli, Emanuele Pacetti, Sara Grammatico, Giampaolo Bucaneve, Robin Foà
BACKGROUND: Carbapenem-resistant Klebsiella pneumoniae (CRKP) spread and infections in patients with haematological malignancies are a serious concern especially in endemic areas. Treatment failures and delay in appropriate therapy for CRKP infections are frequent and the mortality rate associated with CRKP bacteremia in neutropenic haematological patients is reported about 60%. METHODS: Haematological patients harboring CRKP hospitalized between February 2012 and May 2013 in an Italian Teaching hospital were examined...
March 10, 2017: BMC Infectious Diseases
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