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BMC Infectious Diseases

Yun-Da Li, Chak-Bor Wong, Tsung-Ting Tsai, Po-Liang Lai, Chi-Chien Niu, Lih-Huei Chen, Tsai-Sheng Fu
BACKGROUND: Most guidelines recommend 6 to 12 weeks of parenteral antibiotic treatment for pyogenic spondylodiscitis. When surgical debridement is adequately performed, further intravenous antibiotic treatment duration can be reduced than that of conservative treatment alone theoretically. However, the appropriate duration of post-surgical parenteral antibiotic treatment is still unknown. This study aimed to identify the risk factors of recurrence and evaluate the appropriate duration after surgical intervention...
September 17, 2018: BMC Infectious Diseases
Maria N Chitasombat, Natta Ratchatanawin, Yingluck Visessiri
BACKGROUND: Legionellosis is a well-known cause of pneumonia. Primary cutaneous and subcutaneous infection caused by Legionella pneumophila is rare and the diagnosis is challenging. CASE PRESENTATION: A 38-year-old Thai woman with systemic lupus erythematosus and myasthenia gravis treated with prednisolone and azathioprine presented to our hospital with low-grade fever, diarrhea, and indurated skin lesions on both thighs. Initial examination showed plaques on both inner thighs...
September 17, 2018: BMC Infectious Diseases
Camilla Wistrand, Bo Söderquist, Karin Falk-Brynhildsen, Ulrica Nilsson
BACKGROUND: To prevent cross infection the surgical team perform preoperative hand disinfection before dressed in surgical gowns and gloves. Preoperative hand disinfection does not make hands sterile and the surgical glove cuff end has been regarded as a weak link, since it is not a liquid-proof interface. The aims were to investigate if there were differences in bacterial growth and recolonization of hands between operating room nurses and non-health care workers as well as to investigate if bacterial growth existed at the surgical glove cuff end during surgery...
September 17, 2018: BMC Infectious Diseases
Mikias Negash, Aster Tsegaye, Liya Wassie, Rawleigh Howe
BACKGROUND: Previous studies reported HIV infection alters the distribution and function of γδ T cells and their subsets. γδ T phenotypes in healthy and diseased individuals has received little attention in Ethiopia. We conducted this study to analyze the distribution of γδ T cells, the subsets and levels of expression of activation (CD38), exhaustion or anergy (CD95, PD1), adhesion (N-CAM/CD56 and CD103), among HIV and TB infected patients. METHOD: The distributions of total γδ T cells, Vδ1 and Vδ2 T cells subsets were analyzed in clinical samples collected from asymptomatic HIV, pulmonary TB patients and apparently healthy controls...
September 15, 2018: BMC Infectious Diseases
Ana Caren Cortés-Márquez, Sandra Mendoza-Elizalde, Francisco Arenas-Huertero, Jimena Trillo-Tinoco, Pedro Valencia-Mayoral, Alejandra Consuelo-Sánchez, Jonathan Zarate-Franco, Ada Ruth Dionicio-Avendaño, José de Jesús Herrera-Esquivel, Elio Germán Recinos-Carrera, Christian Colín-Valverde, Sandra Rivera-Gutiérrez, Alfonso Reyes-López, Juan Carlos Vigueras-Galindo, Norma Velázquez-Guadarrama
BACKGROUND: Helicobacter pylori is a major aetiologic agent associated with gastritis. H. pylori infections increase the expression of the Toll-like receptor (TLR), which in turn modulates the expression of microRNA (miRNA)-146a and miRNA-155. The objective of this study was to compare the expression of miRNA-146a and miRNA-155 in gastric lesions of paediatric and adult patients with different pathologies and in Mongolian gerbils (Meriones unguiculatus) infected with H. pylori 26,695...
September 15, 2018: BMC Infectious Diseases
Xin Wang, Zezhou Wang, Xueqin Jiang, Rui Li, Ying Wang, Gang Xu, Huachun Zou, Yong Cai
BACKGROUND: HIV prevalence among men who have sex with men (MSM) in China is rising rapidly, and unprotected anal intercourse (UAI) is associated with HIV transmission. Recent research has shown that associations between UAI and other factors can differ according to the type of sex partners, including regular partners and casual partners. This study aimed to explore the relationship between sexual compulsivity and UAI according to partner type among MSM in Shanghai, China. METHODS: A cross-sectional study was conducted among 547 MSM from four districts in Shanghai, China...
September 15, 2018: BMC Infectious Diseases
Emily Adland, Gerald Jesuthasan, Louise Downs, Victoria Wharton, Gemma Wilde, Anna L McNaughton, Jane Collier, Eleanor Barnes, Paul Klenerman, Monique Andersson, Katie Jeffery, Philippa C Matthews
BACKGROUND: As direct acting antiviral (DAA) therapy is progressively rolled out for patients with hepatitis C virus (HCV) infection, careful scrutiny of HCV epidemiology, diagnostic testing, and access to care is crucial to underpin improvements in delivery of treatment, with the ultimate goal of elimination. METHODS: We retrospectively studied microbiology records from a large UK teaching hospital in order to compare the performance of HCV screening and diagnostic tests (antibody, antigen and HCV RNA detection)...
September 14, 2018: BMC Infectious Diseases
Clarence C Tam, Vittoria Offeddu, Kathryn B Anderson, Alden L Weg, Louis R Macareo, Damon W Ellison, Ram Rangsin, Stefan Fernandez, Robert V Gibbons, In-Kyu Yoon, Sriluck Simasathien
BACKGROUND: Multiplex real-time polymerase chain reaction assays have improved diagnostic sensitivity for a wide range of pathogens. However, co-detection of multiple agents and bacterial colonization make it difficult to distinguish between asymptomatic infection or illness aetiology. We assessed whether semi-quantitative microbial load data can differentiate between symptomatic and asymptomatic states for common respiratory pathogens. METHODS: We obtained throat and nasal swab samples from military trainees at two Thai Army barracks...
September 14, 2018: BMC Infectious Diseases
Roger C Tine, Léon A Ndiaye, Mbayame N Niang, Davy E Kiori, Ndongo Dia, Oumar Gaye, Hélène Broutin
BACKGROUND: Acute Respiratory Infections (ARI) are common causes of febrile illnesses in many settings in Senegal. These infections are usually managed presumptively due to lack of appropriate diagnostic tools. This situation, can lead to poor management of febrile illness or antibiotic misuse. In addition, there are limited data on the spectrum of pathogens commonly responsible for these ARI. This study was conducted to explore the pathogens community among patients with acute respiratory infection in a rural area in Senegal...
September 10, 2018: BMC Infectious Diseases
Huiming Sun, Shuxiang Li, Yongdong Yan, Zhengrong Chen, Yuqing Wang, Chuangli Hao, Wei Ji
BACKGROUND: This study aimed to investigate the occurrence of Cytomegalovirus (CMV) DNA in the Bronchoalveolar lavage fluid (BALF) of children with recurrent wheezing and to identify associations with certain patient clinical characteristics. METHODS: In this cross-sectional study, pediatric patients (age < 36 months) admitted to Soochow University Hospital with recurrent wheezing (≥ 4 episodes of wheezing per year) were enrolled in the study. Cytomegalovirus DNA from their BALF was detected by real-time PCR...
September 10, 2018: BMC Infectious Diseases
Sandra Matinyi, Muwanguzi Enoch, Deborah Akia, Valentine Byaruhanga, Edson Masereka, Isaac Ekeu, Collins Atuheire
BACKGROUND: Microbial contamination of hospital environment, especially in operating theatres (OT) and other specialized units has greatly contributed to continuous and multiple exposure to nosocomial infections by patients and the public. We purposed to assess microbial contamination of operating theatres and antibacterial sensitivity pattern of bacteria isolated from theatres of Mbale Regional Referral Hospital, Eastern Uganda. METHODS: We employed a laboratory based cross-sectional study design...
September 10, 2018: BMC Infectious Diseases
Youn Jeong Kim, Ji Young Kang, Sang Il Kim, Mee Soo Chang, Yang Ree Kim, Yeon Joon Park
BACKGROUNDS: Extrapulmonary tuberculosis (EPTB) is a heterogeneous disease, and diagnosis is sometimes difficult. We investigated the diagnostic performance of the QuantiFERON-TB Gold assay (QFT-GIT) according to sites of EPTB and predictors for false-negative QFT-GIT results. METHODS: A total of 2176 patients were registered with active TB from January 2012 to December 2016 in Seoul St. Mary's Hospital, a 1200-bed tertiary teaching hospital in Seoul, Korea. We retrospectively reviewed the medical records of 163 EPTB patients who underwent QFT-GIT...
September 10, 2018: BMC Infectious Diseases
Mekonnen Girma, Ayalew Astatkie, Solomon Asnake
BACKGROUND: Tungiasis is an ectoparasitic infestation, which still has public health importance in deprived populations of developing countries. Data on the prevalence and risk factors of tungiasis is rare in Ethiopia. Hence, this study was designed to determine the prevalence and risk factors of tungiasis among children in Wensho district, southern Ethiopia. METHODS: From February to May 2016, we conducted a community-based cross-sectional study on 366 children 5-14 years old...
September 10, 2018: BMC Infectious Diseases
Furong Zhang, Yujie Fang, Feng Pang, Shengnan Liang, Xin Lu, Biao Kan, Jianguo Xu, Jinxing Zhao, Yinju Du, Duochun Wang
BACKGROUND: Members of Shewanella species are opportunistic pathogens that are found in marine environments. Currently more than sixty species have been identified, whereas the most commonly clinical cases associated with Shewanella species have involved only two species, i.e., S. algae and S. putrefaciens. We present two cases of pulmonary and bloodstream infections caused by two rare Shewanella spp. strains from patients of gastrointestinal cancer. CASE PRESENTATION: Two male patients with a history of gastrointestinal cancer presented to hospital with pulmonary and bloodstream infections, respectively...
September 5, 2018: BMC Infectious Diseases
Vanitha Mariappan, Surendran Thavagnanam, Kumutha Malar Vellasamy, Cindy Ju Shuan Teh, Nadia Atiya, Sasheela Ponnampalavanar, Jamuna Vadivelu
BACKGROUND: Burkholderia pseudomallei is the causative agent of melioidosis, which is a potentially life threatening disease endemic in Southeast Asian countries. In Malaysia, cystic fibrosis (CF) is an uncommon condition. The association between CF and B.pseudomallei infections has been reported previously. However, this is the first case report of a pediatric melioidosis relapse and co-infection with other Gram-negative bacteria in Malaysia. CASE PRESENTATION: A 14-year-old Chinese Malaysian boy presented with a history of recurrent pneumonia, poor growth and steatorrhoea since childhood, and was diagnosed with CF...
September 5, 2018: BMC Infectious Diseases
Liping Yan, Hongbo Shen, Heping Xiao
BACKGROUND: It is not fully explained why some active tuberculosis patients show negative interferon-γ release assays (IGRAs). In this study, we tried to explore associations of IGRAs with the characteristics of peripheral Vγ2Vδ2 T cells and their functions of producing cytokines. METHODS: 32 pulmonary tuberculosis patients were enrolled and divided into two groups according to their IGRAs results: 16 with IGRA-negative as test group and 16 with IGRA-positive as control group...
September 4, 2018: BMC Infectious Diseases
X Y Li, B X Ke, C N Chen, H L Xiao, M Z Liu, Y C Xiong, R Bai, J D Chen, C W Ke
BACKGROUND: Melioidosis is endemic in Southeast Asia and northern Australia. Infection usually follows percutaneous inoculation or inhalation or ingestion of the causative bacterium, Burkholderia pseudomallei, which is present in soil and surface water in endemic regions. Japanese encephalitis (JE) is a vector-borne viral zoonosis caused by Japanese encephalitis virus (JEV), leading to epidemic encephalitis in Southeast Asia. Both B. pseudomallei and JEV have spread dominantly in the Hainan and Guangdong provinces in China...
September 4, 2018: BMC Infectious Diseases
Jessica Quah, Boran Jiang, Poh Choo Tan, Chuin Siau, Thean Yen Tan
BACKGROUND: The impact of different classes of microbial pathogens on mortality in severe community-acquired pneumonia is not well elucidated. Previous studies have shown significant variation in the incidence of viral, bacterial and mixed infections, with conflicting risk associations for mortality. We aimed to determine the risk association of microbial aetiologies with hospital mortality in severe CAP, utilising a diagnostic strategy incorporating molecular testing. Our primary hypothesis was that respiratory viruses were important causative pathogens in severe CAP and was associated with increased mortality when present with bacterial pathogens in mixed viral-bacterial co-infections...
September 4, 2018: BMC Infectious Diseases
Jason M Bacha, Lynda C Aririguzo, Veronica Mng'ong'o, Beatrice Malingoti, Richard S Wanless, Katherine Ngo, Liane R Campbell, Gordon E Schutze
BACKGROUND: As countries scale up antiretroviral therapy (ART) for children, innovative strategies to deliver quality services to children are needed. Differentiated ART delivery models have been successful in adults, but no such program has been described in children. We describe the Standardized Pediatric Expedited Encounters for ART Drugs Initiative (SPEEDI). METHODS: Descriptive analysis of patients eligible for SPEEDI was done via retrospective review of children, adolescents, and young adults on ART at the Baylor Centre of Excellence (COE) in Mbeya, Tanzania between January 2013 and December 2015...
September 3, 2018: BMC Infectious Diseases
Jie Shi, Danwei Zheng, Yankun Zhu, Xiaoguang Ma, Shaohua Wang, Hui Li, Jin Xing
BACKGROUND: Tuberculosis remains a serious threat to human health as an infectious disease in China. Henan, a most populated province in China, has a high incidence of tuberculosis (TB). Though the genetic diversity of Mycobacterium tuberculosis (MTB) has been investigated in many regions, there have been only a few studies on the molecular characteristics and drug resistance phenotypes in Henan. This is the first study on the genetic profile of MTB from Henan. METHODS: A total of 668 MTB isolates from various areas were genotyped with spoligotyping and 26-locus MIRU-VNTR (classical 24-locus MIRU-VNTR and 2 other loci)...
September 3, 2018: BMC Infectious Diseases
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