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BMC Infectious Diseases

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https://www.readbyqxmd.com/read/29788948/genechip-analysis-of-resistant-mycobacterium-tuberculosis-with-previously-treated-tuberculosis-in-changchun
#1
Ming-Jin Zhang, Wen-Zhi Ren, Xue-Juan Sun, Yang Liu, Ke-Wei Liu, Zhong-Hao Ji, Wei Gao, Bao Yuan
BACKGROUND: With the widespread use of rifampicin and isoniazid, bacterial resistance has become a growing problem. Additionally, the lack of relevant baseline information for the frequency of drug-resistant tuberculosis (TB) gene mutations is a critical issue, and the incidence of this infection in the city of Changchun has not investigated to date. However, compared with the slow traditional methods of drug susceptibility testing, recently developed detection methods, such as rifampicin and isoniazid resistance-related gene chip techniques, allow for rapid, easy detection and simultaneous testing for mutation frequency and drug resistance...
May 22, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29788927/chronic-kirschsteiniothelia-infection-superimposed-on-a-pre-existing-non-infectious-bursitis-of-the-ankle-the-first-case-report-of-human-infection
#2
Masanori Nishi, Ichiro Okano, Takatoshi Sawada, Yasuka Hara, Kiwamu Nakamura, Katsunori Inagaki, Takashi Yaguchi
BACKGROUND: Kirschsteiniothelia is a saprophytic fungus that is abundantly present in the environment. To date, there have been no reports of human infection caused by this fungus. We report a case of Kirschsteiniothelia infection superimposed on a pre-existing non-infectious bursitis of the ankle. CASE PRESENTATION: An 81-year-old immunocompetent female local farmer noticed the presence of a nodule on her right ankle 5 years before her first visit to our hospital...
May 22, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29788910/infection-with-high-proportion-of-multidrug-resistant-bacteria-in-conflict-related-injuries-is-associated-with-poor-outcomes-and-excess-resource-consumption-a-cohort-study-of-syrian-patients-treated-in-jordan
#3
Andreas Älgå, Sidney Wong, Muhammad Shoaib, Kalle Lundgren, Christian G Giske, Johan von Schreeb, Jonas Malmstedt
BACKGROUND: Armed conflicts are a major contributor to injury and death globally. Conflict-related injuries are associated with a high risk of wound infection, but it is unknown to what extent infection directly relates to sustainment of life and restoration of function. The aim of this study was to investigate the outcome and resource consumption among civilians receiving acute surgical treatment due to conflict-related injuries. Patients with and without wound infections were compared...
May 22, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29788907/mycobacterium-avium-complex-vertebral-osteomyelitis-in-the-absence-of-hiv-infection-a-case-report-and-review
#4
Megan E Gray, Peter W Liu, Brian Wispelwey
BACKGROUND: Mycobacterium Avium Complex (MAC) is an established microbiologic cause of pulmonary disease, lymphadenitis, and disseminated disease in cases of advanced immune suppression. However, MAC manifesting as vertebral osteomyelitis is less common, and is particularly rare in the absence of Acquired Immunodeficiency Syndrome (AIDS). Prompt diagnosis of MAC vertebral osteomyelitis is challenging, but necessary to prevent serious morbidity or mortality. CASE PRESENTATION: We report a case of MAC osteomyelitis of the lumbar spine in a 70-year-old woman on extended duration corticosteroid therapy for systemic lupus erythematosus who presented with progressive back pain...
May 22, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29783955/prediction-of-mortality-in-severe-dengue-cases
#5
Saiful Safuan Md-Sani, Julina Md-Noor, Winn-Hui Han, Syang-Pyang Gan, Nor-Salina Rani, Hui-Loo Tan, Kanimoli Rathakrishnan, Mohd Azizuddin A-Shariffuddin, Marzilawati Abd-Rahman
BACKGROUND: Increasing incidence of dengue cases in Malaysia over the last few years has been paralleled by increased deaths. Mortality prediction models will therefore be useful in clinical management. The aim of this study is to identify factors at diagnosis of severe dengue that predicts mortality and assess predictive models based on these identified factors. METHOD: This is a retrospective cohort study of confirmed severe dengue patients that were admitted in 2014 to Hospital Kuala Lumpur...
May 21, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29783953/immunologic-and-virological-response-to-art-among-hiv-infected-individuals-at-a-tertiary-hospital-in-ghana
#6
Dorcas Obiri-Yeboah, Faustina Pappoe, Ibrahim Baidoo, Francis Arthur, Anna Hayfron-Benjamin, Samuel Essien-Baidoo, Godwin Kwakye-Nuako, Stephen Ayisi Addo
BACKGROUND: The need to study the outcome of Antiretroviral Therapy (ART) among Human Immunodeficiency Virus (HIV) infected individuals in Ghana, a sub-Saharan African country crucial in the era of the "Treat All" policy. The aim of this study was to analyze selected determinants of immunological and virological response to ART among HIV infected individuals in a tertiary facility in Cape Coast, Ghana. METHODS: An analytical cross sectional study with a retrospective component was conducted in the Cape Coast Teaching Hospital (CCTH), Central Region...
May 21, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29783937/enterococcus-gallinarum-meningitis-a-case-report-and-literature-review
#7
Bo Zhao, Mao Sheng Ye, Rui Zheng
BACKGROUND: As an opportunistic pathogen, E. gallinarum mainly leads to nosocomial infections, and it's multi-drug resistance has gained more and more attention. Central nervous system infections caused by E. gallinarum are rare, but have been reported more often in recent years. The previous cases were generally secondary to neurosurgery, especially ventriculoperitoneal shunts. In recent years, the cases largely occurred in patients with impaired immune function. The patient in our report may have had dual risk factors (immune impairment and an invasive surgical procedure)...
May 21, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29778101/prevalence-of-self-reported-symptoms-of-sexually-transmitted-infections-knowledge-and-sexual-behaviour-among-youth-in-semi-rural-tanzania-in-the-period-of-adolescent-friendly-health-services-strategy-implementation
#8
Ramadhani Abdul, Annette A M Gerritsen, Mary Mwangome, Eveline Geubbels
BACKGROUND: Global evidence shows that sexually transmitted infections (STIs) prevalence and sexual risk behaviours are high among youth, and knowledge about STIs is low. In Tanzania, there is limited recent evidence regarding these issues. The aim of this study was to describe the health seeking behaviour of youth reporting STI symptoms in semi-rural Tanzania and to evaluate the association of socio-demographic characteristics, STI knowledge and sexual risk behaviour with STI symptom reporting...
May 19, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29776398/primary-bacterial-ventriculitis-in-adults-an-emergent-diagnosis-challenge-report-of-a-meningoccal-case-and-review-of-the-literature
#9
Anaïs Lesourd, Nicolas Magne, Anaïs Soares, Caroline Lemaitre, Muhamed-Kheir Taha, Isabelle Gueit, Michel Wolff, François Caron
BACKGROUND: Defined by an infection of the ventricular system of the brain, ventriculitis is usually known as a health-care associated infection. In contrast, primary pyogenic ventriculitis complicating community-acquired meningitis is uncommon, and mainly described in infants. Only seven cases that have occured in adults have been found in the international literature. CASE PRESENTATION: We report here a new case due to Neisseria meningitidis occurring in an 85 year-old-man...
May 18, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29776395/linking-young-men-who-have-sex-with-men-ymsm-to-sti-physicians-a-nationwide-cross-sectional-survey-in-china
#10
Bolin Cao, Peipei Zhao, Cedric Bien, Stephen Pan, Weiming Tang, Julia Watson, Guodong Mi, Yi Ding, Zhenzhou Luo, Joseph D Tucker
BACKGROUND: Many young men who have sex with men (YMSM) are reluctant to seek health services and trust local physicians. Online information seeking may encourage YMSM to identify and see trustworthy physicians, obtain sexual health services, and obtain testing for sexually transmitted infections (STIs). This study examined online STI information seeking behaviors among Chinese YMSM and its association with offline physician visits. METHODS: We conducted a nationwide online survey among YMSM through WeChat, the largest social media platform in China...
May 18, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29776392/molecular-identification-of-tick-borne-pathogens-in-asymptomatic-individuals-with-human-immunodeficiency-virus-type-1-hiv-1-infection-a-retrospective-study
#11
Renata Welc-Falęciak, Justyna D Kowalska, Małgorzata Bednarska, Magdalena Szatan, Agnieszka Pawełczyk
BACKGROUND: The studies on the occurrence and diversity of tick-borne infections in HIV-infected individuals have been few, and the subject has been relatively neglected when compared with other common infections associated with HIV. In HIV-positive patients in whom a serological diagnostics is complicated due to reduced positive predictive value, a method where the microorganism is detected directly is of great value. Therefore, we performed a molecular study to ascertain the prevalence and incidence of tick-borne infections in HIV-infected persons in Poland, an endemic area for Ixodes ricinus ticks...
May 18, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29769038/impact-of-new-daa-therapy-on-real-clinical-practice-a-multicenter-region-wide-cohort-study
#12
Simone Lanini, Paola Scognamiglio, Alessandra Mecozzi, Lorella Lombardozzi, Vincenzo Vullo, Mario Angelico, Antonio Gasbarrini, Gloria Taliani, Adolfo Francesco Attili, Carlo Federico Perno, Adriano De Santis, Vincenzo Puro, Fabio Cerqua, Gianpiero D'Offizi, Adriano Pellicelli, Orlando Armignacco, Francesco Saverio Mennini, Massimo Siciliano, Enrico Girardi, Vincenzo Panella, Giuseppe Ippolito
BACKGROUND: Management of chronic hepatitis C (CHC) has significantly accelerated in the last few years. Currently, second generation direct acting antivirals (DAAs) promise clearance of infection in most of patients. Here we present the results of the first analysis carried out on data of Lazio clinical network for DAAs. METHODS: The study was designed as a multicenter cohort: a) to assess the evolution of treatment during the first 24 months of the activity of the Clinical Network; b) to report overall efficacy of treatments; c) to analyze potential factors associated with lack of virological response at 12 weeks after therapy (SVR12); d) to evaluate the variation of ALT at baseline and 12 weeks after therapy in those who achieved SVR12 in comparison to those who did not...
May 16, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29769036/estimates-of-state-level-chronic-hepatitis-c-virus-infection-stratified-by-race-and-sex-united-states-2010
#13
Eric W Hall, Eli S Rosenberg, Patrick S Sullivan
BACKGROUND: Hepatitis C virus (HCV) is the most common blood-borne viral infection in the United States. Previously, we used data from the National Health and Nutrition Examination Survey (NHANES) and mortality data from the National Vital Statistics System (NVSS) to estimate the prevalence of HCV antibodies (anti-HCV) and HCV RNA among all U.S. states. However, demographic differences in HCV burden at the state-level have not been systematically described. This analysis quantified the HCV burden stratified by sex and race (and associated disparities) for each U...
May 16, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29769034/demand-side-determinants-of-timely-vaccination-of-oral-polio-vaccine-in-social-mobilization-network-areas-of-core-group-polio-project-in-uttar-pradesh-india
#14
Manojkumar Choudhary, Roma Solomon, Jitendra Awale, Rina Dey
BACKGROUND: Children who receive all doses of scheduled vaccines reduce their susceptibility to vaccine-preventable diseases. In India, full immunization coverage has increased significantly. However, only a small proportion of children are immunized on time. Globally, studies on factors affecting coverage of childhood immunization have found a significant impact by demand and supply-side determinants. This paper explores the demand-side determinants of timely immunization of the third dose of oral polio vaccine (OPV3) among children aged 6-11 months in the catchment areas of CORE Group Polio Project India...
May 16, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29769028/-careful-goodbye-at-the-door-is-there-role-for-antimicrobial-stewardship-interventions-for-antimicrobial-therapy-prescribed-on-hospital-discharge
#15
R Chavada, J Davey, L O'Connor, D Tong
BACKGROUND: Antimicrobial stewardship (AMS) interventions largely target inpatient antimicrobial prescribing. Literature on appropriateness of antimicrobials prescribed at the interface between hospital and the community is minimal. This study was designed to assess the appropriateness of antimicrobials prescribed on hospital discharge and evaluate the impact of AMS interventions. METHODS: Patients with discharge medications processed by the pharmacy were identified using a computerized pharmacy medication tracker over a four week period...
May 16, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29764399/the-reachability-of-contagion-in-temporal-contact-networks-how-disease-latency-can-exploit-the-rhythm-of-human-behavior
#16
Ewan Colman, Kristen Spies, Shweta Bansal
BACKGROUND: The symptoms of many infectious diseases influence their host to withdraw from social activity limiting their potential to spread. Successful transmission therefore requires the onset of infectiousness to coincide with a time when the host is socially active. Since social activity and infectiousness are both temporal phenomena, we hypothesize that diseases are most pervasive when these two processes are synchronized. METHODS: We consider disease dynamics that incorporate behavioral responses that effectively shorten the infectious period of the pathogen...
May 15, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29764381/isolation-of-mycobacterium-arupense-from-pleural-effusion-culprit-or-not
#17
Xian Zhou, Qiaoling Ruan, Weimin Jiang, Xinyu Wang, Yuan Jiang, Shenglei Yu, Yu Xu, Jing Li, Yangyi Zhang, Wenhong Zhang, Yuekai Hu
BACKGROUND: Mycobacterium arupense, first identified in 2006, is a slow-growing nontuberculous mycobacterium (NTM) and an emerging cause of tenosynovitis, potentially associated with immunosuppression. However, unlike the diagnostic value of its isolation from osteoarticular specimens, the significance of detecting M. arupense in respiratory specimens is not yet clear. CASE PRESENTATION: To our knowledge, we, for the first time, described the identification of M...
May 15, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29764370/-tuberculosis-in-advanced-hiv-infection-is-associated-with-increased-expression-of-ifn%C3%AE-and-its-downstream-targets
#18
Sheetal Verma, Peicheng Du, Damalie Nakanjako, Sabine Hermans, Jessica Briggs, Lydia Nakiyingi, Jerrold J Ellner, Yukari C Manabe, Padmini Salgame
BACKGROUND: Tuberculosis (TB) is the major cause of death in Human Immunodeficiency Virus (HIV)-infected individuals. However, diagnosis of TB in HIV remains challenging particularly when HIV infection is advanced. Several gene signatures and serum protein biomarkers have been identified that distinguish active TB from latent infection. Our study was designed to assess if gene expression signatures and cytokine levels would distinguish active TB in advanced HIV. METHODS: We conducted a case-control study of whole blood RNA-Seq and plasma cytokine/chemokine analysis in HIV-infected with CD4+ T cell count of ≤ 100 cells/μl, with and without active TB...
May 15, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29764368/airborne-geographical-dispersal-of-q-fever-from-livestock-holdings-to-human-communities-a-systematic-review-and-critical-appraisal-of-evidence
#19
Nicholas J Clark, Ricardo J Soares Magalhães
BACKGROUND: Q fever is a zoonotic disease caused by Coxiella burnetii. This bacterium survives harsh conditions and attaches to dust, suggesting environmental dispersal is a risk factor for outbreaks. Spatial epidemiology studies collating evidence on Q fever geographical contamination gradients are needed, as human cases without occupational exposure are increasing worldwide. METHODS: We used a systematic literature search to assess the role of distance from ruminant holdings as a risk factor for human Q fever outbreaks...
May 15, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29751747/a-fatal-case-associated-with-respiratory-syncytial-virus-infection-in-a-young-child
#20
Lili Xu, Hengmiao Gao, Jiansheng Zeng, Jun Liu, Cong Lu, Xiaolei Guan, Suyun Qian, Zhengde Xie
BACKGROUND: Respiratory syncytial virus (RSV) is the most common viral cause of pediatric bronchiolitis and pneumonia worldwide. Risk factors for high mortality and prolonged morbidity after RSV infection include premature birth, bronchopulmonary dysplasia, congenital heart disease, and Down syndrome. However, some previously healthy, full-term children who are infected with RSV also require hospitalization and even experience severe sequelae or death. CASE PRESENTATION: In this report, we present the case of an RSV-associated death of a child who was born at full-term and developed normally up to the age of 2 years old...
May 11, 2018: BMC Infectious Diseases
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