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BMC Infectious Diseases

Pedro Palma, Andreia Costa, Raquel Duro, Nélia Neves, Cândida Abreu, António Sarmento
BACKGROUND: Cytomegalovirus (CMV) reactivation with neurological involvement in patients with acquired immunodeficiency syndrome (AIDS) is increasingly rare since the introduction of antiretroviral therapy (ART). Manifestations include encephalitis, myelitis, polyradiculopathy and, less commonly, mononeuritis multiplex (MNM). We report a case of disseminated CMV disease with gastrointestinal and peripheral and central nervous system involvement in a patient with AIDS, manifesting primarily as MNM...
November 12, 2018: BMC Infectious Diseases
Jinjian Fu, Yanling Ding, Yongjiang Jiang, Shengfu Mo, Shaolin Xu, Peixu Qin
BACKGROUND: The prevalence and risk factors for persistent candidemia among very low birth weight infants are poorly understood. This study aimed to investigate the epidemiology of persistent candidemia over a 4-year period in a neonatal intensive care unit (NICU) in Liuzhou, China. METHODS: We retrospectively extracted demographic data, risk factors, microbiological results and outcomes of very low birth weight infants with candidemia in our hospital between January 2012 and November 2015...
November 12, 2018: BMC Infectious Diseases
Andrea Giacomelli, Agostino Riva, Felicia Stefania Falvella, Maria Letizia Oreni, Dario Cattaneo, Stefania Cheli, Giulia Renisi, Valentina Di Cristo, Angelica Lupo, Emilio Clementi, Stefano Rusconi, Massimo Galli, Anna Lisa Ridolfo
BACKGROUND: Nevirapine has been used as antiretroviral agent since early '90. Although nevirapine is not currently recommended in initial anti-HIV regimens, its use remains consistent in a certain number of HIV-1-positive subjects. Thus, our aim was to determine clinical and genetic factors involved in the development of severe nevirapine induced liver toxicity. METHODS: We retrospectively analyzed all HIV positive patients who were followed at the Infectious Diseases Unit, DIBIC Luigi Sacco, University of Milan from May 2011 to December 2015...
November 12, 2018: BMC Infectious Diseases
Hoang Van Tong, Nguyen Van Ba, Nghiem Xuan Hoan, Mai Thanh Binh, Dao Thanh Quyen, Ho Anh Son, Hoang Van Luong, Do Quyet, Christian G Meyer, Le Huu Song, Nguyen Linh Toan, Thirumalaisamy P Velavan
BACKGROUND: Clinical progression of HBV-related liver diseases is largely associated with the activity of HBV-specific T cells. Soluble fibrinogen-like protein 2 (sFGL2), mainly secreted by T cells, is an important effector molecule of the immune system. METHODS: sFGL2 levels were determined by ELISA assays in sera of 296 HBV patients clinically classified into the subgroups of acute hepatitis B (AHB), chronic hepatitis B (CHB), liver cirrhosis (LC), hepatocellular carcinoma (HCC) and patients with LC plus HCC...
November 12, 2018: BMC Infectious Diseases
Jen-Chung Liao, Po-Liang Lai, Lih-Hui Chen, Chi-Chien Niu
BACKGROUND: Infection after vertebroplasty (VP) is a rare but serious complication. Previous literatures showed most pathogens for infection after VP were bacteria; tuberculosis (TB) induced infection after VP was extremely rare. We reported our treatment experiences of cases with infectious spondylitis after VP, and compared the differences between developed pyogenic and TB spondylitis. METHODS: From January 2001 to December 2015, 5749 patients had undergone VP at our department were reviewed retrospectively...
November 12, 2018: BMC Infectious Diseases
Asfaw Ayalew, Zewdu Gashu, Tadesse Anteneh, Nebiyu Hiruy, Dereje Habte, Degu Jerene, Genetu Alem, Ilili Jemal, Muluken Melese, Pedro G Suarez
BACKGROUND: Globally recommended measures for comprehensive tuberculosis (TB) infection control (IC) are inadequately practiced in most health care facilities in Ethiopia. The aim of this study was to assess the extent of implementation of TB IC measures before and after introducing a comprehensive technical support package in two regions of Ethiopia. METHODS: We used a quasi-experimental design, whereby a baseline assessment of TB IC practices in 719 health care facilities was conducted between August and October 2013...
November 12, 2018: BMC Infectious Diseases
Esmaeil Mortaz, Somayeh Sarhifynia, Majid Marjani, Afshin Moniri, Davood Mansouri, Payam Mehrian, Karin van Leeuwen, Dirk Roos, Johan Garssen, Ian M Adcock, Payam Tabarsi
BACKGROUND: Genetic mutations that reduce intracellular superoxide production by granulocytes causes chronic granulomatous disease (CGD). These patients suffer from frequent and severe bacterial and fungal infections throughout their early life. Diagnosis is usually made in the first 2 years of life but is sometimes only diagnosed when the patient is an adult although they may have suffered from symptoms since childhood. CASE PRESENTATION: A 26-year-old man was referred with weight loss, fever, hepatosplenomegaly and coughing...
November 8, 2018: BMC Infectious Diseases
Young-Jae Ki, Dong-Min Kim, Na-Ra Yoon, Sung-Soo Kim, Choon-Mee Kim
BACKGROUND: Scrub typhus is a zoonotic disease caused by Orientia tsutsugamushi, a gram-negative intracellular bacterium. Myocarditis and rhabdomyolysis are rare complications of scrub typhus. CASE PRESENTATION: We report a case of scrub typhus, which was simultaneously complicated with myocarditis and rhabdomyolysis. A 54-year-old woman presented to our hospital with myalgia in the upper and lower limbs, oedema and a fever of 7 days' duration. We confirmed the diagnosis of scrub typhus complicated with myocarditis by pericardial fluid analysis and cardiac magnetic resonance imaging results...
November 7, 2018: BMC Infectious Diseases
Simon C Masha, Piet Cools, Patrick Descheemaeker, Marijke Reynders, Eduard J Sanders, Mario Vaneechoutte
BACKGROUND: Screening of curable sexually transmitted infections is frequently oriented towards the diagnosis of chlamydia, gonorrhea, syphilis and trichomoniasis, whereas other pathogens, sometimes associated with similar urogenital syndromes, remain undiagnosed and/or untreated. Some of these pathogens are associated with adverse pregnancy outcomes. METHODS: In a nested case-control study, vaginal swabs from 79 pregnant women, i.e., 28 T. vaginalis-positive (cases) and 51 T...
November 6, 2018: BMC Infectious Diseases
Avital Hirsch, Mark A Katz, Alon Laufer Peretz, David Greenberg, Rachael Wendlandt, Yonat Shemer Avni, Gabriella Newes-Adeyi, Ilan Gofer, Maya Leventer-Roberts, Nadav Davidovitch, Anat Rosenthal, Rachel Gur-Arie, Tomer Hertz, Aharona Glatman-Freedman, Arnold S Monto, Eduardo Azziz-Baumgartner, Jill Morris Ferdinands, Emily Toth Martin, Ryan E Malosh, Joan Manuel Neyra Quijandría, Min Levine, William Campbell, Ran Balicer, Mark G Thompson
BACKGROUND: The Study of Healthcare Personnel with Influenza and other Respiratory Viruses in Israel (SHIRI) prospectively follows a cohort of healthcare personnel (HCP) in two hospitals in Israel. SHIRI will describe the frequency of influenza virus infections among HCP, identify predictors of vaccine acceptance, examine how repeated influenza vaccination may modify immunogenicity, and evaluate influenza vaccine effectiveness in preventing influenza illness and missed work. METHODS: Cohort enrollment began in October, 2016; a second year of the study and a second wave of cohort enrollment began in June 2017...
November 6, 2018: BMC Infectious Diseases
Mayra Gonçalves Menegueti, Gilberto Gambero Gaspar, Ana Maria Laus, Anibal Basile-Filho, Fernando Bellissimo-Rodrigues, Maria Auxiliadora-Martins
BACKGROUND: The Leuconostoc mesenteroides are members of the Streptococcae family and currently has been recognized as potential pathogens. This case describes a bacteremia caused by L. mesenteroides in an immunocompetent patient affected by Chagas disease. CASE PRESENTATION: A 67-year-old female patient with chagasic megaesophagus and megacolon was submitted to a Heller myotomy for achalasia in 2000 and endoscopic dilatation in 2015. Patient was admitted to the Nutrology Ward in May 2016 with protein-calorie malnutrition associated with achalasia and receiving enteral nutrition...
November 3, 2018: BMC Infectious Diseases
Naomi Kemunto, Eddy Mogoa, Eric Osoro, Austin Bitek, M Kariuki Njenga, S M Thumbi
BACKGROUND: The East African region is endemic with multiple zoonotic diseases and is one of the hotspots for emerging infectious zoonotic diseases with reported multiple outbreaks of epidemic diseases such as Ebola, Marburg and Rift Valley Fever. Here we present a systematic assessment of published research on zoonotic diseases in the region and thesis research in Kenya to understand the regional research focus and trends in publications, and estimate proportion of theses research transitioning to peer-reviewed journal publications...
November 3, 2018: BMC Infectious Diseases
Déborah Ferreira Noronha de Castro Rocha, Luana Rocha da Cunha Rosa, Carla de Almeida Silva, Brunna Rodrigues de Oliveira, Thaynara Lorrane Silva Martins, Regina Maria Bringel Martins, Marcos André de Matos, Megmar Aparecida Dos Santos Carneiro, Juliana Pontes Soares, Ana Cristina de Oliveira E Silva, Márcia Maria de Souza, Robert L Cook, Karlla Antonieta Amorim Caetano, Sheila Araujo Teles
BACKGROUND: In recent decades the epidemic of asymptomatic sexually transmitted infections has extended deep into Brazil, including small towns and rural areas. The purpose of this study was to investigate the epidemiology of HIV, syphilis, and hepatitis B (HBV) and hepatitis C viruses (HCV), and to evaluate immunization coverage against hepatitis B in a group of rural workers in Brazil. METHODS: In 2016, a cross-sectional study was conducted with 937 manual sugarcane cutters of the Midwest and Northeast Regions of Brazil...
November 3, 2018: BMC Infectious Diseases
Leocadia Kwagonza, Ben Masiira, Henry Kyobe-Bosa, Daniel Kadobera, Emily B Atuheire, Bernard Lubwama, Atek Kagirita, Edson Katushabe, John T Kayiwa, Julius J Lutwama, Joseph C Ojwang, Issa Makumbi, Alex Riolexus Ario, Jeff Borchert, Bao-Ping Zhu
BACKGROUND: On 28 March, 2016, the Ministry of Health received a report on three deaths from an unknown disease characterized by fever, jaundice, and hemorrhage which occurred within a one-month period in the same family in central Uganda. We started an investigation to determine its nature and scope, identify risk factors, and to recommend eventually control measures for future prevention. METHODS: We defined a probable case as onset of unexplained fever plus ≥1 of the following unexplained symptoms: jaundice, unexplained bleeding, or liver function abnormalities...
November 3, 2018: BMC Infectious Diseases
Jing Miao, Xuan Guo, Weili Liu, Dong Yang, Zhiqiang Shen, Zhigang Qiu, Xiang Chen, Kunming Zhang, Hui Hu, Jing Yin, Zhongwei Yang, Junwen Li, Min Jin
BACKGROUND: Enteric viruses in surface water pose considerable risk to morbidity in populations living around water catchments and promote outbreaks of waterborne diseases. However, due to poor understanding of the correlation between water quality and the presence of human enteric viruses, the failure to assess viral contamination through alternative viral indicators makes it difficult to control disease transmission. METHODS: We investigated the occurrence of Enteroviruses (EnVs), Rotaviruses (HRVs), Astroviruses (AstVs), Noroviruses GII (HuNoVs GII) and Adenoviruses (HAdVs) from Jinhe River over 4 years and analyzed their correlation with physicochemical and bacterial parameters in water samples...
November 1, 2018: BMC Infectious Diseases
Yun Qian, Qixin Han, Wenjun Liu, Wei-En Yuan, Cunyi Fan
BACKGROUND: China had the third highest burden of tuberculosis population in the world. Bone and joint tuberculosis was a major part and its characteristics were rarely discussed before. This study was designed to review the characteristics and management of bone and joint tuberculosis among native and migrant population in Shanghai, China during 2011-2015. METHODS: A retrospective analysis of the patient clinical records on their demographic information, clinical features and treatment was conducted from three tertiary referral hospitals...
November 1, 2018: BMC Infectious Diseases
Peizhen Zhao, Li Liu, Ye Zhang, Huanhuan Cheng, Bolin Cao, Chuncheng Liu, Cheng Wang, Bin Yang, Chongyi Wei, Joseph D Tucker, Weiming Tang
BACKGROUND: Increasing human immunodeficiency virus (HIV) testing is critical for HIV control. This study aimed to evaluate the interaction between social norms and self-efficacy on HIV testing among Chinese men who have sex with men (MSM). METHODS: We conducted an online survey in eight Chinese cities in Shandong and Guangdong Provinces in July 2016. We included participants who were born as a male, at least 16 years old, currently living in one of the designated cities, and had ever engaged in anal sex with a man...
October 30, 2018: BMC Infectious Diseases
Pembe Issamou Mayengue, Roch Fabien Niama, Dezi Kouhounina Batsimba, Alida Malonga-Massanga, Igor Louzolo, Nadia Claricelle Loukabou Bongolo, Lucette Macosso, Reyna Ibara Ottia, Ghyslain Kimbassa Ngoma, Louis Régis Dossou-Yovo, Brice Pembet Singana, Gabriel Ahombo, Géril Sekangue Obili, Simon Charles Kobawila, Henri Joseph Parra
BACKGROUND: In the Republic of Congo, artemisinin-based combinations have been recommended for the treatment of uncomplicated malaria since 2006. However, the emergence of resistant parasites again these combinations in Southeast Asia is a threat for the control of this disease, especially in sub-Saharan Africa where the weight of the disease is important. Indeed, polymorphisms in Plasmodium falciparum K13-propeller gene have been involved in variations of drug sensitivity of Plasmodium falciparum to artemisinin-based combinations...
October 29, 2018: BMC Infectious Diseases
Komal Chacowry Pala, Stéphanie Baggio, Nguyen Toan Tran, François Girardin, Hans Wolff, Laurent Gétaz
BACKGROUND: Incarcerated people carry a high burden of infection, including blood-borne diseases (BBDs). It is also known that one million people contract a sexually transmitted infection (STI) every day worldwide, which represents a global public health challenge. However, data regarding the prevalence of STIs and the risk factors among incarcerated populations are lacking. The objective of this study was to determine the prevalence and associated factors of BBDs and STIs among detainees in the largest pre-trial prison in Switzerland...
October 29, 2018: BMC Infectious Diseases
A Bal, M Pichon, C Picard, J S Casalegno, M Valette, I Schuffenecker, L Billard, S Vallet, G Vilchez, V Cheynet, G Oriol, S Trouillet-Assant, Y Gillet, B Lina, K Brengel-Pesce, F Morfin, L Josset
BACKGROUND: In recent years, metagenomic Next-Generation Sequencing (mNGS) has increasingly been used for an accurate assumption-free virological diagnosis. However, the systematic workflow evaluation on clinical respiratory samples and implementation of quality controls (QCs) is still lacking. METHODS: A total of 3 QCs were implemented and processed through the whole mNGS workflow: a no-template-control to evaluate contamination issues during the process; an internal and an external QC to check the integrity of the reagents, equipment, the presence of inhibitors, and to allow the validation of results for each sample...
October 29, 2018: BMC Infectious Diseases
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