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BMC Gastroenterology

Seiichi Shinji, Yoshibumi Ueda, Takeshi Yamada, Michihiro Koizumi, Yasuyuki Yokoyama, Goro Takahashi, Masahiro Hotta, Takuma Iwai, Keisuke Hara, Kohki Takeda, Mikihiro Okusa, Hayato Kan, Eiji Uchida, Hiroshi Yoshida
BACKGROUND: Anastomotic leakage (AL) is the most serious and common complication of surgery for rectal cancer, and associated risk factors remain unknown despite developments in laparoscopic surgery. The present study aimed to determine risk factors for AL after laparoscopic anterior resection (AR) of rectal cancer. METHODS: This retrospective cohort study extracted information from a prospective database of all consecutive colorectal resections that proceeded at Nippon Medical School Hospital between January 2011 and December 2015 (n = 865)...
July 17, 2018: BMC Gastroenterology
Irene Martinucci, Michela Natilli, Valentina Lorenzoni, Luca Pappalardo, Anna Monreale, Giuseppe Turchetti, Dino Pedreschi, Santino Marchi, Roberto Barale, Nicola de Bortoli
BACKGROUND: Gastroesophageal reflux disease (GERD) is one of the most common gastrointestinal disorders worldwide, with relevant impact on the quality of life and health care costs.The aim of our study is to assess the prevalence of GERD based on self-reported symptoms among university students in central Italy. The secondary aim is to evaluate lifestyle correlates, particularly eating habits, in GERD students using automatically recorded transactions through cashiers at university canteen...
July 17, 2018: BMC Gastroenterology
Danielle C Sample, N Jewel Samadder, Lisa M Pappas, Kenneth M Boucher, Wade S Samowitz, Therese Berry, Michelle Westover, Deepika Nathan, Priyanka Kanth, Kathryn R Byrne, Randall W Burt, Deborah W Neklason
BACKGROUND: Patients with familial adenomatous polyposis (FAP) frequently undergo colectomy to reduce the 70 to 90% lifetime risk of colorectal cancer. After risk-reducing colectomy, duodenal cancer and complications from duodenal surgeries are the main cause of morbidity. Our objective was to prospectively describe the duodenal and gastric polyp phenotype in a cohort of 150 FAP patients undergoing pre-screening for a chemoprevention trial and analyze variables that may affect recommendations for surveillance...
July 16, 2018: BMC Gastroenterology
Tilman Kühn, Tobias Nonnenmacher, Disorn Sookthai, Ruth Schübel, Daniel Antonio Quintana Pacheco, Oyunbileg von Stackelberg, Mirja E Graf, Theron Johnson, Christopher L Schlett, Romy Kirsten, Cornelia M Ulrich, Rudolf Kaaks, Hans-Ulrich Kauczor, Johanna Nattenmüller
BACKROUND: Non-alcoholic fatty liver disease (NAFLD) comprises non-progressive steatosis and non-alcoholic steatohepatitis (NASH), the latter of which may cause cirrhosis and hepatocellular carcinoma (HCC). As NAFLD detection is imperative for the prevention of its complications, we evaluated whether a combination of blood-based biomarkers and anthropometric parameters can be used to predict NAFLD among overweight and obese adults. METHODS: 143 overweight or obese non-smokers free of diabetes (50% women, age: 35-65 years) were recruited...
July 13, 2018: BMC Gastroenterology
Pengwei Cui, Jingxin Li, Na Liu, Zhao-Jun Duan
BACKGROUND: Acute diarrheal illness (ADI) is an important public health problem worldwide. We estimated the morbidity, distribution, and burden of self-reported ADI in China over the last three decades. METHODS: We used the keywords "diarrhea and morbidity" to identify studies published in Chinese by searching CNKI, WANFANG, Chongqing VIP, and SinoMed. Studies published in English were identified using the keywords "diarrhea, morbidity, and China" to search Pubmed/Medline, Embase, and Cochrane Library Data...
July 13, 2018: BMC Gastroenterology
Zhimin Liu, Zhifeng Zhang, Mei Huang, Xiaoping Sun, Bojia Liu, Qiyang Guo, Qingshan Chang, Zhijun Duan
BACKGROUND: Previous studies have indicated that bile acid is associated with progression of liver cirrhosis. However, the particular role of specific bile acid in the development of liver cirrhosis is not definite. The present study aims to identify the specific bile acid and explore its possible mechanisms in promoting liver cirrhosis. METHODS: Thirty two cirrhotic patients and 27 healthy volunteers were enrolled. Age, gender, Child-Pugh classification and serum of patients and volunteers were collected...
July 11, 2018: BMC Gastroenterology
Yuusaku Sugihara, Sakiko Hiraoka, Nobuharu Fujii, Shiho Takashima, Yasushi Yamasaki, Toshihiro Inokuchi, Masahiro Takahara, Kenji Kuwaki, Keita Harada, Takehiro Tanaka, Hiroyuki Okada
BACKGROUND: Graft-versus-host disease (GVHD) is a common complication of allo-hematopoietic stem cell transplantation (allo-HSCT). Endoscopic biopsy can provide a definitive diagnosis, but the optimal endoscopic approach for diagnosis remains uncertain. This study evaluated whether ileocolonoscopic imaging can predict acute GVHD severity after allo-HSCT. METHODS: Consecutive patients who underwent allo-HSCT were referred to our institution, and those diagnosed with acute GVHD by pathology were included in this retrospective study...
July 11, 2018: BMC Gastroenterology
Amira Widyasari, Winona Alda Pravitasari, Andi Dwihantoro, Gunadi
After publication of the original article [1], the authors reported that the Acknowledgments section was incomplete. The full section is the following.
July 9, 2018: BMC Gastroenterology
Bashu Dev Pardhe, Shreena Shakya, Anjeela Bhetwal, Jennifer Mathias, Puspa Raj Khanal, Roshan Pandit, Jyotsna Shakya, Hari Om Joshi, Sujan Babu Marahatta
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is mutually and bidirectionally linked with metabolic syndrome (MetS) of which it is both the cause and the consequences. Worldwide, 6.3 to 33% of the general populations are estimated to suffer from the disease with even higher prevalence in the group sharing metabolic co-morbidities. Hence, this study aims to recognize various risk factors including metabolic components and blood parameters to predict the possible incidence of the disease...
July 6, 2018: BMC Gastroenterology
Marta Gravito-Soares, Elisa Gravito-Soares, Dário Gomes, Nuno Almeida, Luís Tomé
BACKGROUND: Acute pancreatitis (AP) is associated with considerable morbidity and mortality. Current severity scores include multiple variables and some of them are only complete within 48 h of admission. Red cell distribution width (RDW) is a simple and routine parameter that seems to be related to inflammatory status. Our aims were to evaluate the diagnostic value of RDW in severity and mortality of AP comparing with other prognostic scoring systems. METHODS: Retrospective case-control study of a total of 312 patients with AP admitted between 2014 and 2016...
July 5, 2018: BMC Gastroenterology
Chaoyong Shen, Yuan Yin, Huijiao Chen, Ruixue Wang, Xiaonan Yin, Zhaolun Cai, Bo Zhang, Zhixin Chen, Zongguang Zhou
BACKGROUND: Malignant growth and metastasis of gastrointestinal stromal tumors (GIST) occur in some patients even during the course of treatment, but their mechanisms remains poorly understand at the molecular level so far. METHODS: Profiles of protein expression in gastric GIST tissues were explored using protein microarray analysis, down-regulation of SPARCL1 (secreted protein acidic and rich in cysteine-like protein 1) was validated by RT-qPCR, western blot and immunohistochemistry...
July 4, 2018: BMC Gastroenterology
Yunxiao Lyu, Yunxiao Cheng, Bin Wang, Yueming Xu, Weibing Du
BACKGROUND: Recently, although studies have investigated the role of NSAIDs in the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP), selection of the ideal drug, the time and route of its administration for the appropriate population remain controversial. METHODS: A systematic search was done in sources including PubMed, Embase, Web of Science, the Cochrane Library Central, and from from August 1, 1990 to August 1, 2017...
July 4, 2018: BMC Gastroenterology
Anjali Sharma, Ujjal Poddar, Shikha Agnihotry, Shubha R Phadke, Surender K Yachha, Rakesh Aggarwal
BACKGROUND: Progressive familial intrahepatic cholestasis (PFIC) is caused by variations in ATP8B1, ABCB11 or ABCB4 genes. Data on genetic variations in Indian patients with PFIC are lacking. METHODS: Coding and splice regions of the three genes were sequenced in unrelated Indian children with PFIC phenotype. The variations identified were looked for in parents, 30 healthy persons and several variation databases, and their effect was assessed in-silico. RESULTS: Among 25 children (aged 1-144 months), nine (36%) had unique major genomic variations (ATP8B1: 4, ABCB11: 3 and ABCB4: 2)...
July 4, 2018: BMC Gastroenterology
Ke Chen, Xiao-Long Liu, Yu Pan, Hendi Maher, Xian-Fa Wang
BACKGROUND: Laparoscopic pancreaticoduodenectomy (LPD) remains to be established as a safe and effective alternative to open pancreaticoduodenectomy (OPD) for pancreatic-head and periampullary malignancy. The purpose of this meta-analysis was to compare LPD with OPD for these malignancies regarding short-term surgical and long-term survival outcomes. METHODS: A literature search was conducted before March 2018 to identify comparative studies in regard to outcomes of both LPD and OPD for the treatment of pancreatic-head and periampullary malignancies...
July 3, 2018: BMC Gastroenterology
Ziqing Ye, Aijuan Xue, Ying Huang, Qiye Wu
BACKGROUND: Cyclic vomiting syndrome (CVS) is characterized by repeated, stereotypical vomiting episodes. It is possibly associated with mitochondrial DNA (mtDNA) variants. We examined the phenotype, disease burden, treatment and performed mtDNA analysis in pediatric CVS. METHODS: This retrospective study included 42 children with CVS in a tertiary care center. Information regarding medical history, clinical features, laboratory tests, and treatment were collected...
July 3, 2018: BMC Gastroenterology
Gyu Young Pih, Hee Kyong Na, Ji Yong Ahn, Kee Wook Jung, Do Hoon Kim, Jeong Hoon Lee, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
BACKGROUND: Percutaneous endoscopic gastrostomy (PEG) is a relatively safe procedure; however, acute and chronic complications of PEG have been reported. We aimed to determine risk factors associated with complications and 30-day mortality after PEG, based on 11 years of experience at a single tertiary hospital. METHODS: In total, 401 patients who underwent first PEG insertion at the Asan Medical Center, Seoul, Korea, between January 2005 and December 2015 were eligible...
June 28, 2018: BMC Gastroenterology
Lei Gu, Fei Xu, Jie Yuan
BACKGROUND: This study aims to compare the performance of AIMS65, Glasgow-Blatchford (GBS) and Rockall scores (RS) in predicting the death risk among emergency-hospitalized patients with upper gastrointestinal bleeding (UGIB) in regional China. METHODS: A retrospective study was implemented between January 2014 and December 2015. Eligible participants were those who were hospitalized with UGIB. The outcome variable was in-hospital death, while explanatory variables were AIMS65, GBS and RS scores...
June 28, 2018: BMC Gastroenterology
Yin-Ling Wang, Xin-Xin Ge, Yi Wang, Meng-Dan Xu, Fei-Ran Gong, Min Tao, Wen-Jie Wang, Liu-Mei Shou, Kai Chen, Meng-Yao Wu, Wei Li
BACKGROUND: The classifications and counts of white blood cells (WBCs) have been proved to be able to be used as prognostic markers in cancer cases. The present study investigated the potential values of the classifications and counts of WBC, including lymphocyte (LY), monocyte (MO), neutrophil (NE), eosinophil (EO), and basophil (BA) in the prognosis of resectable gastric cancers (GCs). METHODS: This retrospective study recruited 104 resectable GC cases which were pathologically confirmed...
June 28, 2018: BMC Gastroenterology
Yong Juan Wang, Yu Ming Wang, Yan Min Zheng, Hui Qing Jiang, Jie Zhang
BACKGROUND: Pneumatosis cystoides intestinalis (PCI) is characterized by gas-filled cysts in the intestinal submucosa and subserosa. There are few reports of PCI occurring in duodenum and rectum. Here we demonstrated four different endoscopic manifestations of PCI and three cases with intestinal stricture all were successfully managed by medical conservative treatment. CASE PRESENTATION: There are 6 cases of PCI with varied causes encountered, in which the etiology, endoscopic features, treatment methods and prognosis of patients were studied...
June 28, 2018: BMC Gastroenterology
Jia-Qi Li, Xin-Bao Xie, Jia-Yan Feng, Lian Chen, Kuerbanjiang Abuduxikuer, Yi Lu, Yu-Chuan Li, Jian-She Wang
BACKGROUND: Transient infantile hypertriglyceridemia (HTGTI) is an autosomal recessive disorder caused by mutations in the glycerol-3-phosphate dehydrogenase 1 (GPD1) gene. CASE PRESENTATION: We report a case of HTGTI in a Chinese female infant. She presented with hepatomegaly, hypertriglyceridemia, moderately elevated transaminases, and hepatic steatosis at 3.5 months of age. A novel mutation c.523C>T, p. (Q175*) was identified in GPD1. The patient was a homozygote and her parents were heterozygous for the mutation...
June 25, 2018: BMC Gastroenterology
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