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BMC Gastroenterology

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https://www.readbyqxmd.com/read/28915899/association-between-polymorphisms-of-tas2r16-and-susceptibility-to-colorectal-cancer
#1
Jonathan Barontini, Marco Antinucci, Sergio Tofanelli, Maurizio Cammalleri, Massimo Dal Monte, Federica Gemignani, Pavel Vodicka, Roberto Marangoni, Ludmila Vodickova, Juozas Kupcinskas, Veronika Vymetalkova, Asta Forsti, Federico Canzian, Angelika Stein, Victor Moreno, Nicola Mastrodonato, Francesca Tavano, Anna Panza, Roberto Barale, Stefano Landi, Daniele Campa
BACKGROUND: Genetics plays an important role in the susceptibility to sporadic colorectal cancer (CRC). In the last 10 years genome-wide association studies (GWAS) have identified over 40 independent low penetrance polymorphic variants. However, these loci only explain around 1‑4% of CRC heritability, highlighting the dire need of identifying novel risk loci. In this study, we focused our attention on the genetic variability of the TAS2R16 gene, encoding for one of the bitter taste receptors that selectively binds to salicin, a natural antipyretic that resembles aspirin...
September 15, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28870162/estimation-of-utility-weights-for-major-liver-diseases-according-to-disease-severity-in-korea
#2
Minsu Ock, So Yun Lim, Hyeon-Jeong Lee, Seon-Ha Kim, Min-Woo Jo
BACKGROUND: The global burden of liver diseases, such as hepatocellular carcinoma and liver cirrhosis, is substantial. In this study, we estimated utility weights of liver disease-related health states in the general population using a visual analogue scale (VAS) and the standard gamble (SG) method. METHODS: Depictions of standardized health states related to major liver diseases were developed based on patient education materials and previous publications. To fully reflect disease progression from diagnosis to prognosis, each health state comprised four parts: diagnosis, symptoms, treatment, and progression and prognosis...
September 5, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28854883/addition-of-nucleoside-analogues-to-peg-ifn%C3%AE-2a-enhances-virological-response-in-chronic-hepatitis-b-patients-without-early-response-to-peg-ifn%C3%AE-2a-a-randomized-controlled-trial
#3
Yan Xu, Xu Wang, Zhenhua Liu, Changyu Zhou, Wenqian Qi, Jian Jiao, Fan Yu, Honghua Guo, Ping Zhao, Jiangbin Wang
BACKGROUND: Current treatments for chronic hepatitis B (CHB) include pegylated interferon alpha (PEG-IFN-α) which is an immune modulator, and nucleos(t)ide analogs (NAs) which directly inhibit HBV DNA polymerase. With the limited efficacy of PEG-IFN-α and prolonged treatment periods associated with NAs, there is an urgent need for novel therapeutic strategies, especially for patients with a poor early response to anti-viral therapy. METHODS: In this study, 178 patients with chronic hepatitis B (n = 131) and compensated (n = 47) HBV-induced cirrhosis were enrolled, 120 patients with HBeAg (+)...
August 30, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28841822/diminished-accuracy-of-biomarkers-of-fibrosis-in-low-replicative-chronic-hepatitis-b
#4
Faisal M Sanai, Taha Farah, Khalid Albeladi, Faisal Batwa, Yaser Dahlan, Mohammed A Babatin, Hamad Al-Ashgar, Hadeel AlMana, Khaled S Alsaad, Khalid AlSwat, Abdulrahman Aljumah, Ibrahim H AlTraif, Bahaa E Kailani, Khalid I Bzeizi
BACKGROUND: We evaluated the diagnostic accuracy of aspartate aminotransferase (AST)-to-platelet ratio index (APRI), fibrosis-4 index (FIB-4), AST/alanine aminotransferase (ALT) ratio (AAR), and age-platelet index (API) for significant fibrosis (Metavir F2-4) in low-replicative (HBV DNA <20,000 IU/mL) chronic hepatitis B virus (HBV) patients. METHODS: The sensitivity, specificity, and area under the receiver-operating characteristic curve (AUROC) of HBeAg-negative, low-replicative (n = 213) and high-replicative (HBV DNA ≥20,000 IU/mL, n = 153) patients was assessed...
August 25, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28836936/protective-effects-of-heme-oxygenase-1-against-severe-acute-pancreatitis-via-inhibition-of-tumor-necrosis-factor-%C3%AE-and-augmentation-of-interleukin-10
#5
Fei-Hu Zhang, Yu-Han Sun, Kai-Liang Fan, Xiao-Bin Dong, Ning Han, Hao Zhao, Li Kong
BACKGROUND: Heme oxygenase-1 (HO-1) is an inducible defense gene which plays a significant role in inflammation. HO-1 protects cells and tissues through the mechanism of anti-oxidation, maintaining microcirculation and anti-inflammation. The aim of the current study is to investigate the role of HO-1 on systemic inflammatory response in severe acute pancreatitis (SAP). METHODS: Forty male Sprague-Dawley (SD) rats were randomly assigned into four groups: control group (n = 10); SAP group (n = 10), SAP model was induced by retrograde injection of 3% sodium taurocholate through pancreatic duct; HO-1 stimulation group (n = 10), SD rats were injected 75 μg/kg hemin intraperitoneally 30 min after induction of SAP; HO-1 inhibition group (n = 10), SD rats were injected 20 μg/kg Zinc porphyrin (Zn-PP) intraperitoneally 30 min after induction of SAP...
August 24, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28814273/add-on-neurological-benefits-of-antiviral-therapy-in-hcv-patients-with-chronic-kidney-disease-a-nationwide-cohort-study
#6
Ming-Shyan Lin, Tien-Hsing Chen, Wey-Yil Lin, Chi-Hung Liu, Yung-Yu Hsieh, Wen-Nan Chiu, Chih-Hsiang Chang, Mei-Yen Chen, Chang-Min Chung, Yu-Sheng Lin
BACKGROUND: Hepatitis C virus (HCV)-infected patients with chronic kidney disease (CKD) have rarely been studied because they rarely accept interferon-based therapy (IBT) and have been difficult to follow up. We investigated long-term outcomes of IBT on the population. METHODS: This population-based cohort study used the Taiwan National Health Insurance Research Database as its data source. HCV patients diagnosed with CKD between Jan. 1, 2003, and Dec. 31, 2013, were selected...
August 16, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28797231/survival-benefit-of-transarterial-chemoembolization-in-patients-with-metastatic-hepatocellular-carcinoma-a-single-center-experience
#7
Dominik Bettinger, Renan Spode, Nicolas Glaser, Nico Buettner, Tobias Boettler, Christoph Neumann-Haefelin, Thomas Baptist Brunner, Eleni Gkika, Lars Maruschke, Robert Thimme, Michael Schultheiss
BACKGROUND: As prognosis of patients with metastatic hepatocellular carcinoma (HCC) is mainly determined by intrahepatic HCC progression, local treatment with TACE may result in improved OS, although it is not recommended. The purpose of this study was to analyze retrospectively the efficacy of TACE and its impact on OS in patients with metastatic hepatocellular carcinoma (HCC). METHODS: Two hundred and fifteen patients with metastatic HCC who were treated at our Liver Center between 2003 and 2014 were included in this retrospective analysis...
August 10, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28789636/drug-persistence-and-need-for-dose-intensification-to-adalimumab-therapy-the-importance-of-therapeutic-drug-monitoring-in-inflammatory-bowel-diseases
#8
Lorant Gonczi, Zsuzsanna Kurti, Mariann Rutka, Zsuzsanna Vegh, Klaudia Farkas, Barbara D Lovasz, Petra A Golovics, Krisztina B Gecse, Balazs Szalay, Tamas Molnar, Peter L Lakatos
BACKGROUND: Therapeutic drug monitoring (TDM) aid therapeutic decision making in patients with inflammatory bowel disease (IBD) who lose response to anti-TNF therapy. Our aim was to evaluate the frequency and predictive factors of loss of response (LOR) to adalimumab using TDM in IBD patients. METHODS: One hundred twelve IBD patients (with 214 TDM measurements, CD/UC 84/28, male/female 50/62, mean age CD/UC: 36/35 years) were enrolled in this consecutive cohort from two referral centres in Hungary...
August 8, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28789631/efficacy-of-glutathione-for-the-treatment-of-nonalcoholic-fatty-liver-disease-an-open-label-single-arm-multicenter-pilot-study
#9
Yasushi Honda, Takaomi Kessoku, Yoshio Sumida, Takashi Kobayashi, Takayuki Kato, Yuji Ogawa, Wataru Tomeno, Kento Imajo, Koji Fujita, Masato Yoneda, Koshi Kataoka, Masataka Taguri, Takeharu Yamanaka, Yuya Seko, Saiyu Tanaka, Satoru Saito, Masafumi Ono, Satoshi Oeda, Yuichiro Eguchi, Wataru Aoi, Kenji Sato, Yoshito Itoh, Atsushi Nakajima
BACKGROUND: Glutathione plays crucial roles in the detoxification and antioxidant systems of cells and has been used to treat acute poisoning and chronic liver diseases by intravenous injection. This is a first study examining the therapeutic effects of oral administration of glutathione in patients with nonalcoholic fatty liver disease (NAFLD). METHODS: The study was an open label, single arm, multicenter, pilot trial. Thirty-four NAFLD patients diagnosed using ultrasonography were prospectively evaluated...
August 8, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28789612/lichenoid-esophagitis-presenting-as-fatal-upper-gastrointestinal-bleeding-in-a-52%C3%A2-year-old-woman-a-case-diagnosed-by-autopsy
#10
Andrew Mitchell, Tony Petrella
BACKGROUND: "Lichenoid esophagitis" is a descriptive term for a lichenoid pattern of inflammation in the esophagus for which a precise histologic diagnosis cannot be established. The differential diagnosis includes lichen planus, a drug-related reaction, and viral infection. Lichenoid esophagitis causing death has not been reported previously. We describe a case, diagnosed by autopsy, of lichenoid esophagitis in which massive bleeding from generalized epithelial sloughing and a large longitudinal ulcer proved fatal...
August 8, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28784105/a-superficial-esophageal-cancer-in-an-epiphrenic-diverticulum-treated-by-endoscopic-submucosal-dissection
#11
Kuangi Fu, Peng Jin, Yuqi He, Masanori Suzuki, Jianqiu Sheng
BACKGROUND: We report a unique case of a superficial esophageal cancer arising in a single diverticulum, diagnosed with magnifying image-enhanced endoscopy and then successfully treated by endoscopic submucosal dissection (ESD). CASE PRESENTATION: A 66-year-old man with alcohol-related liver injury visited our hospital for endoscopy for investigation of varix. Esophagogastroduodenoscopy showed no varix but a large epiphrenic diverticulum with an area of fainted redness just above the esophagogastric junction...
August 7, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28784100/a-case-report-of-prostate-cancer-metastasis-to-the-stomach-resembling-undifferentiated-type-early-gastric-cancer
#12
Chiaki Inagaki, Takuto Suzuki, Yoshiyasu Kitagawa, Taro Hara, Taketo Yamaguchi
BACKGROUND: Occurrence of metastatic cancer to the stomach is rare, particularly in patients with prostate cancer. Gastric metastasis generally presents as a solitary and submucosal lesion with a central depression. CASE PRESENTATION: We describe a case of gastric metastasis arising from prostate cancer, which is almost indistinguishable from the undifferentiated-type gastric cancer. A definitive diagnosis was not made until endoscopic resection. On performing both conventional and magnifying endoscopies, the lesion appeared to be slightly depressed and discolored area and it could not be distinguished from undifferentiated early gastric cancer...
August 7, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28784097/oral-soft-tissue-disorders-are-associated-with-gastroesophageal-reflux-disease-retrospective-study
#13
Masaaki Watanabe, Eiji Nakatani, Hiroo Yoshikawa, Takahiro Kanno, Yoshiki Nariai, Aya Yoshino, Michael Vieth, Yoshikazu Kinoshita, Joji Sekine
BACKGROUND: Dental erosion (DE), one of oral hard tissue diseases, is one of the extraoesophageal symptoms defined as the Montreal Definition and Classification of gastroesophageal reflux disease (GERD). However, no study evaluated the relationship between GERD and oral soft tissues. We hypothesized that oral soft tissue disorders (OSTDs) would be related to GERD. The study aimed to investigate the association OSTDs and GERD. METHODS: GERD patients (105 cases), older and younger controls (25 cases each) were retrospectively examined for oral symptoms, salivary flow volume (Saxon test), swallowing function (repetitive saliva swallowing test [RSST]), teeth (decayed, missing, and filled [DMF] indices), and soft tissues (as evaluation of OSTDs, gingivitis; papillary, marginal, and attached [PMA] gingival indexes, simplified oral hygiene indices [OHI-S], and inflammatory oral mucosal regions)...
August 7, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28764761/abnormalities-in-ileal-stem-neurogenin-3-and-enteroendocrine-cells-in-patients-with-irritable-bowel-syndrome
#14
Magdy El-Salhy, Odd Helge Gilja
BACKGROUND: This study examined whether the densities of stem- and enteroendocrine cell progenitors are abnormal in the ileum of patients with irritable bowel syndrome (IBS), and whether any abnormalities in ileal enteroendocrine cells are correlated with abnormalities in stem cells and enteroendocrine cell progenitors. METHODS: One hundred and one IBS patients covering all IBS subtypes were recruited, and 39 non-IBS subjects were included as a control group. The patients and controls underwent standard colonoscopies, during which biopsy specimens were obtained from the ileum...
August 1, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28764652/tissue-sublimation-follow-transarterial-embolization-of-a-follicular-nodular-hyperplasia-of-the-liver-report-of-a-case
#15
Peter C Ambe, Stefan Jansen, Hubert Zirngibl
BACKGROUND: Follicular nodular hyperplasia (FNH) is a common benign liver tumor for which conservative management is indicated. Surgical or interventional management is indicated in symptomatic cases. Transarterial embolization (TAE) has been extensively used to manage unresectable liver tumors. Sublimation describes a change of physical state from solid to gas. Hepatic tissue sublimation following TAE has so far not been reported in medical literature. CASE PRESENTATION: A 30 year - old male patient presenting with pain to the upper abdomen due to a large FNH was managed with TAE...
August 1, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28760134/life-threatening-bleeding-from-gastric-dieulafoy-s-lesion-in-a-pregnant-woman-with-hellp-syndrome-a-case-report-and-literature-review
#16
Chen Si, Zhu Xiuli, Xie Li, Jia Yong, Zhou Ying, Zhang Kaiguang
BACKGROUND: Dieulafoy's lesion (DL) is one of the rare causes of upper gastrointestional bleeding. This disease is characterized by small sub-mucosal arteriole that eroded the stomach mucosa and cause severe upper GI bleeding without obvious ulceration. The most common location is fundus area of stomach and usually affects patients over 50 years of age with multiple comorbidities. CASE PRESENTATION: We report a case of life-threatening bleeding from DL during late pregnancy 31 weeks...
July 31, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28728545/the-potential-value-of-serum-pepsinogen-for-the-diagnosis-of-atrophic-gastritis-among-the-health-check-up-populations-in-china-a-diagnostic-clinical-research
#17
Yuling Tong, Yulian Wu, Zhenya Song, Yingying Yu, Xinyan Yu
BACKGROUND: The aim of this study is to assess the validity of the measurement of pepsinogen as a screening test for chronic atrophic gastritis (AG) in health check-up populations in China. METHODS: Patients from consecutive regular health check-up were enrolled from January 2014 to June 2015. Endoscopy, combined with monitoring the Helicobacter pylori (Hp) infections, and measuring the serum pepsinogen (PG) were used to determine the diagnostic accuracy of PG for the screening of atrophic gastritis...
July 20, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28701149/the-prevalence-of-gastric-heterotopia-of-the-proximal-esophagus-is-underestimated-but-preneoplasia-is-rare-correlation-with-barrett-s-esophagus
#18
Ulrich Peitz, Michael Vieth, Matthias Evert, Jovana Arand, Albert Roessner, Peter Malfertheiner
BACKGROUND: The previously reported prevalence of gastric heterotopia in the cervical esophagus, also termed inlet patch (IP), varies substantially, ranging from 0.18 to 14%. Regarding cases with adenocarcinoma within IP, some experts recommend to routinely obtain biopsies from IP for histopathology. Another concern is the reported relation to Barrett's esophagus. The objectives of the study were to prospectively determine the prevalence of IP and of preneoplasia within IP, and to investigate the association between IP and Barrett's esophagus...
July 12, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28687068/erratum-to-serum-albumin-a-good-indicator-of-persistent-organ-failure-in-acute-pancreatitis
#19
Shoukang Li, Yushun Zhang, Mengjiao Li, Chao Xie, Heshui Wu
No abstract text is available yet for this article.
July 7, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28683721/risk-of-colorectal-cancer-among-immigrants-to-ontario-canada
#20
Lawrence Paszat, Rinku Sutradhar, Ying Liu, Nancy N Baxter, Jill Tinmouth, Linda Rabeneck
BACKGROUND: The risk of colorectal cancer (CRC) varies around the world and between females and males. We aimed to compare the risk of CRC among immigrants to Ontario, Canada, to its general population. METHODS: We used an exposure-control matched design. We identified persons in the Immigration, Refugees and Citizenship Canada Permanent Resident Database with first eligibility for the Ontario Health Insurance Plan between July 1, 1991 and June 30, 2008 at age 40 years or older, and matched five controls by year of birth and sex on the immigrant's first eligibility date...
July 6, 2017: BMC Gastroenterology
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