journal
MENU ▼
Read by QxMD icon Read
search

BMC Medical Research Methodology

journal
https://www.readbyqxmd.com/read/29788915/the-appropriateness-of-bland-altman-s-approximate-confidence-intervals-for-limits-of-agreement
#1
Gwowen Shieh
BACKGROUND: Percentiles are widely used as reference limits for determining the relative magnitude and substantial importance of quantitative measurements. An important application is the advocated Bland-Altman limits of agreement. METHODS: To contribute to the data analysis and design planning of reference limit or percentile research, the purpose of this paper is twofold. The first is to clarify the statistical features of interval estimation procedures for normal percentiles...
May 22, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29783954/methods-to-systematically-review-and-meta-analyse-observational-studies-a-systematic-scoping-review-of-recommendations
#2
Monika Mueller, Maddalena D'Addario, Matthias Egger, Myriam Cevallos, Olaf Dekkers, Catrina Mugglin, Pippa Scott
BACKGROUND: Systematic reviews and meta-analyses of observational studies are frequently performed, but no widely accepted guidance is available at present. We performed a systematic scoping review of published methodological recommendations on how to systematically review and meta-analyse observational studies. METHODS: We searched online databases and websites and contacted experts in the field to locate potentially eligible articles. We included articles that provided any type of recommendation on how to conduct systematic reviews and meta-analyses of observational studies...
May 21, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29776431/validation-of-verbal-autopsy-methods-using-hospital-medical-records-a-case-study-in-vietnam
#3
Hong Thi Tran, Hoa Phuong Nguyen, Sue M Walker, Peter S Hill, Chalapati Rao
BACKGROUND: Information on causes of death (COD) is crucial for measuring the health outcomes of populations and progress towards the Sustainable Development Goals. In many countries such as Vietnam where the civil registration and vital statistics (CRVS) system is dysfunctional, information on vital events will continue to rely on verbal autopsy (VA) methods. This study assesses the validity of VA methods used in Vietnam, and provides recommendations on methods for implementing VA validation studies in Vietnam...
May 18, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29776399/simulation-based-power-calculations-for-planning-a-two-stage-individual-participant-data-meta-analysis
#4
Joie Ensor, Danielle L Burke, Kym I E Snell, Karla Hemming, Richard D Riley
BACKGROUND: Researchers and funders should consider the statistical power of planned Individual Participant Data (IPD) meta-analysis projects, as they are often time-consuming and costly. We propose simulation-based power calculations utilising a two-stage framework, and illustrate the approach for a planned IPD meta-analysis of randomised trials with continuous outcomes where the aim is to identify treatment-covariate interactions. METHODS: The simulation approach has four steps: (i) specify an underlying (data generating) statistical model for trials in the IPD meta-analysis; (ii) use readily available information (e...
May 18, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29776394/influence-of-blinding-on-treatment-effect-size-estimate-in-randomized-controlled-trials-of-oral-health-interventions
#5
Humam Saltaji, Susan Armijo-Olivo, Greta G Cummings, Maryam Amin, Bruno R da Costa, Carlos Flores-Mir
BACKGROUND: Recent methodologic evidence suggests that lack of blinding in randomized trials can result in under- or overestimation of the treatment effect size. The objective of this study is to quantify the extent of bias associated with blinding in randomized controlled trials of oral health interventions. METHODS: We selected all oral health meta-analyses that included a minimum of five randomized controlled trials. We extracted data, in duplicate, related to nine blinding-related criteria, namely: patient blinding, assessor blinding, care-provider blinding, investigator blinding, statistician blinding, blinding of both patients and assessors, study described as "double blind", blinding of patients, assessors, and care providers concurrently, and the appropriateness of blinding...
May 18, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29769018/informative-graphing-of-continuous-safety-variables-relative-to-normal-reference-limits
#6
Christopher D Breder
BACKGROUND: Interpreting graphs of continuous safety variables can be complicated because differences in age, gender, and testing site methodologies data may give rise to multiple reference limits. Furthermore, data below the lower limit of normal are compressed relative to those points above the upper limit of normal. The objective of this study is to develop a graphing technique that addresses these issues and is visually intuitive. METHODS: A mock dataset with multiple reference ranges is initially used to develop the graphing technique...
May 16, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29751746/validating-the-use-of-veterans-affairs-tobacco-health-factors-for-assessing-change-in-smoking-status-accuracy-availability-and-approach
#7
Anne C Melzer, Erika A Pinsker, Barbara Clothier, Siamak Noorbaloochi, Diana J Burgess, Elisheva R Danan, Steven S Fu
BACKGROUND: Accurate smoking status is key for research purposes, but can be costly and difficult to measure. Within the Veteran's Health Administration (VA), smoking status is recorded as part of routine care as "health factors" (HF)-fields that researchers can query through the electronic health record (EHR). Many researchers are interested in using these fields to track changes in smoking status over time, however the validity of this measure for assessing change is unknown...
May 11, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29739352/nature-and-reporting-characteristics-of-uk-health-technology-assessment-systematic-reviews
#8
Christopher Carroll, Eva Kaltenthaler
BACKGROUND: A recent study by Page et al. (PLoS Med. 2016;13(5):e1002028) claimed that increasing numbers of reviews are being published and many are poorly-conducted and reported. The aim of the present study was to assess how well reporting standards of systematic reviews produced in a Health Technology Assessment (HTA) context compare with reporting in Cochrane and other 'non-Cochrane' systematic reviews from the same years (2004 and 2014), as reported by Page et al. (PLoS Med. 2016;13(5):e1002028)...
May 8, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29739339/comparison-of-methodological-quality-rating-of-systematic-reviews-on-neuropathic-pain-using-amstar-and-r-amstar
#9
Svjetlana Dosenovic, Antonia Jelicic Kadic, Katarina Vucic, Nikolina Markovina, Dawid Pieper, Livia Puljak
BACKGROUND: Systematic reviews (SRs) in the field of neuropathic pain (NeuP) are increasingly important for decision-making. However, methodological flaws in SRs can reduce the validity of conclusions. Hence, it is important to assess the methodological quality of NeuP SRs critically. Additionally, it remains unclear which assessment tool should be used. We studied the methodological quality of SRs published in the field of NeuP and compared two assessment tools. METHODS: We systematically searched 5 electronic databases to identify SRs of randomized controlled trials of interventions for NeuP available up to March 2015...
May 8, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29739338/measuring-colorectal-cancer-incidence-the-performance-of-an-algorithm-using-administrative-health-data
#10
Mamadou Diop, Erin C Strumpf, Geetanjali D Datta
BACKGROUND: Certain cancer case ascertainment methods used in Quebec and elsewhere are known to underestimate the burden of cancer, particularly for some subgroups. Algorithms using claims data are a low-cost option to improve the quality of cancer surveillance, but have not frequently been implemented at the population-level. Our objectives were to 1) develop a colorectal cancer (CRC) case ascertainment algorithm using population-level hospitalization and physician billing data, 2) validate the algorithm, and 3) describe the characteristics of cases...
May 8, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29739337/colliding-ideals-an-interview-study-of-how-intervention-researchers-address-adherence-and-adaptations-in-replication-studies
#11
Ulrica von Thiele Schwarz, Ulrika Förberg, Knut Sundell, Henna Hasson
BACKGROUND: For an intervention to be considered evidence-based, findings need to be replicated. When this is done in new contexts (e.g., a new country), adaptations may be needed. Yet, we know little about how researchers approach this. This study aims to explore how researchers reason about adaptations and adherence when conducting replication studies, describe what adaptations they make and how these are reported in scientific journals. METHODS: This was an interview study conducted in 2014 with principal investigators of Swedish replication studies reporting adaptations to an intervention from another country...
May 8, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29665780/writing-a-discussion-section-how-to-integrate-substantive-and-statistical-expertise
#12
REVIEW
Michael Höfler, John Venz, Sebastian Trautmann, Robert Miller
BACKGROUND: When discussing results medical research articles often tear substantive and statistical (methodical) contributions apart, just as if both were independent. Consequently, reasoning on bias tends to be vague, unclear and superficial. This can lead to over-generalized, too narrow and misleading conclusions, especially for causal research questions. MAIN BODY: To get the best possible conclusion, substantive and statistical expertise have to be integrated on the basis of reasonable assumptions...
April 17, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29618321/correction-to-joint-models-for-longitudinal-and-time-to-event-data-a-review-of-reporting-quality-with-a-view-to-meta-analysis
#13
Maria Sudell, Ruwanthi Kolamunnage-Dona, Catrin Tudur-Smith
Following publication of the original article [1] the authors reported that reference 15 (Cella et al.) had been incorrectly replaced with a duplicate of Brombin et al. during publication.
April 4, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29580203/sample-size-determination-for-mediation-analysis-of-longitudinal-data
#14
Haitao Pan, Suyu Liu, Danmin Miao, Ying Yuan
BACKGROUND: Sample size planning for longitudinal data is crucial when designing mediation studies because sufficient statistical power is not only required in grant applications and peer-reviewed publications, but is essential to reliable research results. However, sample size determination is not straightforward for mediation analysis of longitudinal design. METHODS: To facilitate planning the sample size for longitudinal mediation studies with a multilevel mediation model, this article provides the sample size required to achieve 80% power by simulations under various sizes of the mediation effect, within-subject correlations and numbers of repeated measures...
March 27, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29562900/using-bundle-embeddings-to-predict-daily-cortisol-levels-in-human-subjects
#15
Roelof B Toonen, Klaas J Wardenaar, Elisabeth H Bos, Sonja L van Ockenburg, Peter de Jonge
BACKGROUND: Many biological variables sampled from human subjects show a diurnal pattern, which poses special demands on the techniques used to analyze such data. Furthermore, most biological variables belong to nonlinear dynamical systems, which may make linear statistical techniques less suitable to analyze their dynamics. The current study investigates the usefulness of two analysis techniques based on nonlinear lagged vector embeddings: sequentially weighted global linear maps (SMAP), and bundle embeddings...
March 21, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29548276/quality-assessment-of-systematic-reviews-on-total-hip-or-knee-arthroplasty-using-mod-amstar
#16
Xinyu Wu, Huan Sun, Xiaoqin Zhou, Ji Wang, Jing Li
BACKGROUND: Increasing numbers of systematic reviews (SRs) on total knee arthroplasty (TKA) and total hip arthroplasty (THA) have been published in recent years, but their quality has been unclear. The purpose of this study is to evaluate the methodological quality of SRs on TKA and THA. METHODS: We searched Ovid-Medline, Ovid-Embase, Cochrane Databases (including HTA, DARE, and CDSR), CBM, CNKI, Wang Fang, and VIP, from January 2014 to December 2015 for THA and TKA...
March 16, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29544448/psychometric-properties-and-population-norms-of-the-positive-mental-health-instrument-in-a-representative-multi-ethnic-asian-population
#17
Janhavi Ajit Vaingankar, Mythily Subramaniam, Linda Wei Lin Tan, Edimansyah Abdin, Wei Yen Lim, Hwee Lin Wee, Siow Ann Chong, Rob Martinus van Dam
BACKGROUND: Measures of mental well-being and positive mental health (PMH) have been largely developed and used in Western populations, however, data on representative Asian communities are lacking. Using data from a population sample, this study sought to establish psychometric properties and norms of the PMH Instrument (PMH-I), a measure of positive mental health developed in Singapore. METHODS: We conducted a nationally representative survey among 1925 adults aged 18-79 years of Chinese, Malay, Indian or other ethnicity...
March 15, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29540164/methodological-and-clinical-implications-of-a-three-in-one-russian-doll-design-for-tracking-health-trajectories-and-improving-health-and-function-through-innovative-exercise-treatments-in-adults-with-disability
#18
James H Rimmer, Cassandra Herman, Brooks Wingo, Kevin Fontaine, Tapan Mehta
BACKGROUND: Hybrid research designs targeting adults with neurologic disability are critical for improving the efficiency of models that can identify, track and intervene on identified health issues. METHODS: Our Russian doll framework encompasses three study phases. Phase 1 involves prospectively following a cohort of participants with disability to examine the relationships between rates of health and functional deficits (e.g., pain, fatigue, deconditioning), functional measures (e...
March 14, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29523081/an-application-of-restricted-mean-survival-time-in-a-competing-risks-setting-comparing-time-to-art-initiation-by-injection-drug-use
#19
Keri L Calkins, Chelsea E Canan, Richard D Moore, Catherine R Lesko, Bryan Lau
BACKGROUND: Restricted mean survival time (RMST) is an underutilized estimand in time-to-event analyses. Herein, we highlight its strengths by comparing time to (1) all-cause mortality and (2) initiation of antiretroviral therapy (ART) for HIV-infected persons who inject drugs (PWID) and persons who do not inject drugs. METHODS: RMST to death was determined by integrating the Kaplan-Meier survival curve to 5 years of follow-up. To account for the competing risks of death and loss-to-clinic when estimating time to ART, we calculated RMST to ART initiation by estimating the area between the survival curve for ART initiation and the cumulative incidence curve for death or loss-to-clinic...
March 9, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29514613/pragmatism-in-practice-lessons-learned-during-screening-and-enrollment-for-a-randomised-controlled-trial-in-rural-northern-ethiopia
#20
Meseret Molla, Henok Negussie, Moses Ngari, Esther Kivaya, Patricia Njuguna, Fikre Enqueselassie, James A Berkley, Gail Davey
BACKGROUND: We use the example of the Gojjam Lymphoedema Best Practice Trial (GoLBeT), a pragmatic trial in a remote rural setting in northern Ethiopia, to extract lessons relevant to other investigators balancing the demands of practicality and community acceptability with internal and external validity in clinical trials. METHODS: We explain in detail the preparation for the trial, its setting in northern Ethiopia, the identification and selection of patients (inclusion and exclusion criterion, identifying and screening of patients at home, enrollment of patients at the health centres and health posts), and randomisation...
March 7, 2018: BMC Medical Research Methodology
journal
journal
36184
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"