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BMC Medical Research Methodology

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https://www.readbyqxmd.com/read/27919233/sexual-health-questions-included-in-the-health-behaviour-in-school-aged-children-hbsc-study-an-international-methodological-pilot-investigation
#1
Honor Young, András Költő, Marta Reis, Elizabeth M Saewyc, Nathalie Moreau, Lorraine Burke, Alina Cosma, Béat Windlin, Saoirse Nic Gabhainn, Emmanuelle Godeau
BACKGROUND: This paper describes the methodological developments of the sexual health items included in the Health Behaviour in School-aged Children (HBSC) study since their mandatory inclusion in the study in 2002. The current methodological, ethical and pedagogical challenges in measuring young people's sexual health behaviours are discussed along with the issues associated with the sexual health items introduced to the HBSC study in 2002. The development and piloting of new cross-national items for use in the 2013/14 HBSC data collection are presented and discussed...
December 5, 2016: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/27919231/erratum-to-assessment-of-predictive-performance-in-incomplete-data-by-combining-internal-validation-and-multiple-imputation
#2
Simone Wahl, Anne-Laure Boulesteix, Astrid Zierer, Barbara Thorand, Mark A van de Wiel
No abstract text is available yet for this article.
December 5, 2016: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/27919221/joint-models-for-longitudinal-and-time-to-event-data-a-review-of-reporting-quality-with-a-view-to-meta-analysis
#3
Maria Sudell, Ruwanthi Kolamunnage-Dona, Catrin Tudur-Smith
BACKGROUND: Joint models for longitudinal and time-to-event data are commonly used to simultaneously analyse correlated data in single study cases. Synthesis of evidence from multiple studies using meta-analysis is a natural next step but its feasibility depends heavily on the standard of reporting of joint models in the medical literature. During this review we aim to assess the current standard of reporting of joint models applied in the literature, and to determine whether current reporting standards would allow or hinder future aggregate data meta-analyses of model results...
December 5, 2016: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/27903238/impress-an-implementation-readiness-checklist-developed-using-a-systematic-review-of-randomised-controlled-trials-assessing-cognitive-stimulation-for-dementia
#4
Amy Streater, Aimee Spector, Elisa Aguirre, Jacki Stansfeld, Martin Orrell
BACKGROUND: Research reporting results of clinical trials, psychosocial or technological interventions frequently omit critical details needed to inform implementation in practice. The aim of this article is to develop an Implementation Readiness (ImpRess) checklist, that includes criteria deemed useful in measuring readiness for implementation and apply it to trials of cognitive stimulation in dementia, providing a systematic review of their readiness for widespread implementation. METHODS: Five electronic databases were searched...
December 1, 2016: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/27899073/recommendations-for-the-analysis-of-individually-randomised-controlled-trials-with-clustering-in-one-arm-a-case-of-continuous-outcomes
#5
Laura Flight, Annabel Allison, Munyaradzi Dimairo, Ellen Lee, Laura Mandefield, Stephen J Walters
BACKGROUND: In an individually randomised controlled trial where the treatment is delivered by a health professional it seems likely that the effectiveness of the treatment, independent of any treatment effect, could depend on the skill, training or even enthusiasm of the health professional delivering it. This may then lead to a potential clustering of the outcomes for patients treated by the same health professional, but similar clustering may not occur in the control arm. Using four case studies, we aim to provide practical guidance and recommendations for the analysis of trials with some element of clustering in one arm...
November 29, 2016: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/27899067/drug-placebo-interaction-effect-may-bias-clinical-trials-interpretation-hybrid-balanced-placebo-and-randomized-placebo-controlled-design
#6
Muhammad M Hammami, Safa Hammami, Reem Al-Swayeh, Eman Al-Gaai, Faduma Abdi Farah, Sophia J S De Padua
BACKGROUND: Conventional randomized placebo-controlled study design assumes the absence of drug*placebo interaction. We hypothesized the presence of such an interaction and that conventionally estimated drug effect might be biased. The objectives of the study were to determine the drug*placebo interaction effect (main) and compare conventionally estimated and interaction model-estimated drug effects (secondary). METHODS: We used a hybrid of balanced placebo and randomized placebo-controlled designs...
November 29, 2016: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/27894262/erratum-to-statistical-methodology-for-age-adjustment-of-the-gh-2000-score-detecting-growth-hormone-misuse
#7
Dankmar Böhning, Walailuck Böhning, Nishan Guha, David A Cowan, Peter H Sönksen, Richard I G Holt
No abstract text is available yet for this article.
November 28, 2016: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/27881091/conducting-a-large-multi-site-survey-about-patients-views-on-broad-consent-challenges-and-solutions
#8
Maureen E Smith, Saskia C Sanderson, Kyle B Brothers, Melanie F Myers, Jennifer McCormick, Sharon Aufox, Martha J Shrubsole, Nanibaá A Garrison, Nathaniel D Mercaldo, Jonathan S Schildcrout, Ellen Wright Clayton, Armand H Matheny Antommaria, Melissa Basford, Murray Brilliant, John J Connolly, Stephanie M Fullerton, Carol R Horowitz, Gail P Jarvik, Dave Kaufman, Terri Kitchner, Rongling Li, Evette J Ludman, Catherine McCarty, Valerie McManus, Sarah Stallings, Janet L Williams, Ingrid A Holm
BACKGROUND: As biobanks play an increasing role in the genomic research that will lead to precision medicine, input from diverse and large populations of patients in a variety of health care settings will be important in order to successfully carry out such studies. One important topic is participants' views towards consent and data sharing, especially since the 2011 Advanced Notice of Proposed Rulemaking (ANPRM), and subsequently the 2015 Notice of Proposed Rulemaking (NPRM) were issued by the Department of Health and Human Services (HHS) and Office of Science and Technology Policy (OSTP)...
November 24, 2016: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/27881078/no-rationale-for-1-variable-per-10-events-criterion-for-binary-logistic-regression-analysis
#9
Maarten van Smeden, Joris A H de Groot, Karel G M Moons, Gary S Collins, Douglas G Altman, Marinus J C Eijkemans, Johannes B Reitsma
BACKGROUND: Ten events per variable (EPV) is a widely advocated minimal criterion for sample size considerations in logistic regression analysis. Of three previous simulation studies that examined this minimal EPV criterion only one supports the use of a minimum of 10 EPV. In this paper, we examine the reasons for substantial differences between these extensive simulation studies. METHODS: The current study uses Monte Carlo simulations to evaluate small sample bias, coverage of confidence intervals and mean square error of logit coefficients...
November 24, 2016: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/27876006/predictors-of-in-hospital-mortality-following-major-lower-extremity-amputations-in-type-2-diabetic-patients-using-artificial-neural-networks
#10
Ana Lopez-de-Andres, Valentin Hernandez-Barrera, Roberto Lopez, Pablo Martin-Junco, Isabel Jimenez-Trujillo, Alejandro Alvaro-Meca, Miguel Angel Salinero-Fort, Rodrigo Jimenez-Garcia
BACKGROUND: Outcome prediction is important in the clinical decision-making process. Artificial neural networks (ANN) have been used to predict the risk of post-operative events, including survival, and are increasingly being used in complex medical decision making. We aimed to use ANN analysis to estimate predictive factors of in-hospital mortality (IHM) in patients with type 2 diabetes (T2DM) after major lower extremity amputation (LEA) in Spain. METHODS: We design a retrospective, observational study using ANN models...
November 22, 2016: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/27875992/optimizing-literature-search-in-systematic-reviews-are-medline-embase-and-central-enough-for-identifying-effect-studies-within-the-area-of-musculoskeletal-disorders
#11
Thomas Aagaard, Hans Lund, Carsten Juhl
BACKGROUND: When conducting systematic reviews, it is essential to perform a comprehensive literature search to identify all published studies relevant to the specific research question. The Cochrane Collaborations Methodological Expectations of Cochrane Intervention Reviews (MECIR) guidelines state that searching MEDLINE, EMBASE and CENTRAL should be considered mandatory. The aim of this study was to evaluate the MECIR recommendations to use MEDLINE, EMBASE and CENTRAL combined, and examine the yield of using these to find randomized controlled trials (RCTs) within the area of musculoskeletal disorders...
November 22, 2016: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/27875988/common-data-elements-for-secondary-use-of-electronic-health-record-data-for-clinical-trial-execution-and-serious-adverse-event-reporting
#12
Philipp Bruland, Mark McGilchrist, Eric Zapletal, Dionisio Acosta, Johann Proeve, Scott Askin, Thomas Ganslandt, Justin Doods, Martin Dugas
BACKGROUND: Data capture is one of the most expensive phases during the conduct of a clinical trial and the increasing use of electronic health records (EHR) offers significant savings to clinical research. To facilitate these secondary uses of routinely collected patient data, it is beneficial to know what data elements are captured in clinical trials. Therefore our aim here is to determine the most commonly used data elements in clinical trials and their availability in hospital EHR systems...
November 22, 2016: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/27852237/using-cognitive-pre-testing-methods-in-the-development-of-a-new-evidenced-based-pressure-ulcer-risk-assessment-instrument
#13
S Coleman, J Nixon, J Keen, D Muir, L Wilson, E McGinnis, N Stubbs, C Dealey, E A Nelson
BACKGROUND: Variation in development methods of Pressure Ulcer Risk Assessment Instruments has led to inconsistent inclusion of risk factors and concerns about content validity. A new evidenced-based Risk Assessment Instrument, the Pressure Ulcer Risk Primary Or Secondary Evaluation Tool - PURPOSE-T was developed as part of a National Institute for Health Research (NIHR) funded Pressure Ulcer Research Programme (PURPOSE: RP-PG-0407-10056). This paper reports the pre-test phase to assess and improve PURPOSE-T acceptability, usability and confirm content validity...
November 16, 2016: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/27852234/does-size-really-matter-a-sensitivity-analysis-of-number-of-seeds-in-a-respondent-driven-sampling-study-of-gay-bisexual-and-other-men-who-have-sex-with-men-in-vancouver-canada
#14
Nathan John Lachowsky, Justin Tyler Sorge, Henry Fisher Raymond, Zishan Cui, Paul Sereda, Ashleigh Rich, Eric A Roth, Robert S Hogg, David M Moore
BACKGROUND: Respondent-driven sampling (RDS) is an increasingly used peer chain-recruitment method to sample "hard-to-reach" populations for whom there are no reliable sampling frames. Implementation success of RDS varies; one potential negative factor being the number of seeds used. METHODS: We conducted a sensitivity analysis on estimates produced using data from an RDS study of gay, bisexual and other men who have sex with men (GBMSM) aged ≥16 years living in Vancouver, Canada...
November 16, 2016: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/27846798/improving-incidence-estimation-in-practice-based-sentinel-surveillance-networks-using-spatial-variation-in-general-practitioner-density
#15
Cécile Souty, Pierre-Yves Boëlle
BACKGROUND: In surveillance networks based on voluntary participation of health-care professionals, there is little choice regarding the selection of participants' characteristics. External information about participants, for example local physician density, can help reduce bias in incidence estimates reported by the surveillance network. METHODS: There is an inverse association between the number of reported influenza-like illness (ILI) cases and local general practitioners (GP) density...
November 15, 2016: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/27842500/national-weighting-of-data-from-the-behavioral-risk-factor-surveillance-system-brfss
#16
Ronaldo Iachan, Carol Pierannunzi, Kristie Healey, Kurt J Greenlund, Machell Town
BACKGROUND: The Behavioral Risk Factor Surveillance System (BRFSS) is a network of health-related telephone surveys--conducted by all 50 states, the District of Columbia, and participating US territories-that receive technical assistance from CDC. Data users often aggregate BRFSS state samples for national estimates without accounting for state-level sampling, a practice that could introduce bias because the weighted distributions of the state samples do not always adhere to national demographic distributions...
November 15, 2016: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/27842498/least-absolute-shrinkage-and-selection-operator-type-methods-for-the-identification-of-serum-biomarkers-of-overweight-and-obesity-simulation-and-application
#17
Monica M Vasquez, Chengcheng Hu, Denise J Roe, Zhao Chen, Marilyn Halonen, Stefano Guerra
BACKGROUND: The study of circulating biomarkers and their association with disease outcomes has become progressively complex due to advances in the measurement of these biomarkers through multiplex technologies. The Least Absolute Shrinkage and Selection Operator (LASSO) is a data analysis method that may be utilized for biomarker selection in these high dimensional data. However, it is unclear which LASSO-type method is preferable when considering data scenarios that may be present in serum biomarker research, such as high correlation between biomarkers, weak associations with the outcome, and sparse number of true signals...
November 14, 2016: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/27832765/defining-the-clinical-pathway-in-cochrane-diagnostic-test-accuracy-reviews
#18
G Gopalakrishna, Miranda W Langendam, Rob J P M Scholten, Patrick M M Bossuyt, Mariska M G Leeflang
BACKGROUND: The value of a medical test depends on the context in which it might be used. Ideally, questions, results and conclusions of a diagnostic test accuracy (DTA) systematic review should be presented in light of this context. There is increasing acceptance of the value for knowing the impact a test can have on downstream consequences such as costs, implications for further testing and treatment options however there is currently no explicit guidance on how to address this. Authors of a Cochrane diagnostic review have recently been asked to include the clinical pathway in which a test maybe used...
November 10, 2016: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/27829380/design-and-development-of-the-australian-and-new-zealand-anz-myeloma-and-related-diseases-registry
#19
Krystal Bergin, Elizabeth Moore, Zoe McQuilten, Erica Wood, Bradley Augustson, Hilary Blacklock, Joy Ho, Noemi Horvath, Tracy King, John McNeil, Peter Mollee, Hang Quach, Christopher M Reid, Brian Rosengarten, Patricia Walker, Andrew Spencer
BACKGROUND: Plasma cell dyscrasias (PCD) are a spectrum of disorders resulting from the clonal expansion of plasma cells, ranging from the pre-malignant condition monoclonal gammopathy of undetermined significance (MGUS) to multiple myeloma (MM). MM generates a significant burden of disease on the community and it is predicted that it will increase in both incidence and prevalence owing to an ageing population and longer survival secondary to new therapeutic options. Robust and comprehensive clinical data are currently lacking but are required to define current diagnostic, investigational and management patterns in Australia and New Zealand (ANZ) for comparison to both local and international guidelines for standards of care...
November 9, 2016: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/27829378/erratum-to-a-monte-carlo-simulation-study-comparing-linear-regression-beta-regression-variable-dispersion-beta-regression-and-fractional-logit-regression-at-recovering-average-difference-measures-in-a-two-sample-design
#20
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