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BMC Dermatology

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https://www.readbyqxmd.com/read/27716172/treatment-of-plaque-psoriasis-with-an-ointment-formulation-of-the-janus-kinase-inhibitor-tofacitinib-a-phase-2b-randomized-clinical-trial
#1
Kim A Papp, Robert Bissonnette, Melinda Gooderham, Steven R Feldman, Lars Iversen, Jennifer Soung, Zoe Draelos, Carla Mamolo, Vivek Purohit, Cunshan Wang, William C Ports
BACKGROUND: Most psoriasis patients have mild to moderate disease, commonly treated topically. Current topical agents have limited efficacy and undesirable side effects associated with long-term use. Tofacitinib is a small molecule Janus kinase inhibitor investigated for the topical treatment of psoriasis. METHODS: This was a 12-week, randomized, double-blind, parallel-group, vehicle-controlled Phase 2b study of tofacitinib ointment (2 % and 1 %) applied once (QD) or twice (BID) daily in adults with mild to moderate plaque psoriasis...
October 3, 2016: BMC Dermatology
https://www.readbyqxmd.com/read/27342276/enzymatic-debridement-for-the-treatment-of-severely-burned-upper-extremities-early-single-center-experiences
#2
Tomke Cordts, Johannes Horter, Julian Vogelpohl, Thomas Kremer, Ulrich Kneser, Jochen-Frederick Hernekamp
BACKGROUND: Severe burns of hands and arms are complex and challenging injuries. The Standard of care (SOC) - necrosectomy with skin grafting - is often associated with poor functional or aesthetic outcome. Enzymatic debridement (ED) is considered one promising alternative but, until recently, results proved to be highly variable. METHODS: Between 04/2014 and 04/2015, 16 patients with deep partial- to full-thickness burns of the upper extremities underwent enzymatic debridement (ED) in our Burn Center and were evaluated for extent of additional surgery, wound healing, pain management and functional parameters...
June 24, 2016: BMC Dermatology
https://www.readbyqxmd.com/read/27646659/cutaneous-sarcoidosis-masquerading-as-chronic-cutaneous-lupus-erythematosus-case-report
#3
Marjon Vatanchi, Kaivon Sobhani, Valerie T Fisher, Jeffrey J Meffert
BACKGROUND: Sarcoidosis is a multisystemic granulomatous disease of unknown origin. Chronic cutaneous lupus erythematosus (CCLE) is an autoimmune disease that is associated with autoantibody production and T-cell dysfunction. Cutaneous manifestations of sarcoidosis may mimic CCLE and vice versa making it difficult to reach a diagnosis clinically. CASE PRESENTATION: We present a case of a 57-year-old woman with long-standing sarcoidosis who presented to clinic with diffuse painful plaques that were very distinct and suggestive of CCLE...
2016: BMC Dermatology
https://www.readbyqxmd.com/read/27646558/risk-factors-of-keloids-in-syrians
#4
Abeer Shaheen, Jamal Khaddam, Fadi Kesh
BACKGROUND: Keloid is a benign fibrous growth, which presents in scar tissue of predisposed individuals. It is a result of irregular wound healing, but the exact mechanism is unknown. However, several factors may play a role in keloid formation. To date, there are no studies of keloids in Syria, and limited studies on Caucasians, so we have investigated the risk factors of keloids in Syrians (Caucasians), and this is the main objective of this study. METHODS: Diagnosis of keloids was clinically made after an interview and physical examination...
2016: BMC Dermatology
https://www.readbyqxmd.com/read/27531132/randomized-placebo-control-study-of-insulin-sensitizers-metformin-and-pioglitazone-in-psoriasis-patients-with-metabolic-syndrome-topical-treatment-cohort
#5
Surjit Singh, Anil Bhansali
BACKGROUND: Increased prevalence of metabolic syndrome (MS) is observed in psoriasis. Metformin has shown improvement in cardiovascular risk factors while pioglitazone demonstrated anti proliferative, anti-inflammatory and anti angiogenic effects. Study objective is to evaluate the efficacy and safety of Insulin sensitizers (metformin and pioglitazone) in psoriasis patients with metabolic syndrome (MS). METHODS: Single centre, parallel group, randomized, study of metformin, pioglitazone and placebo in psoriasis patients with MS...
2016: BMC Dermatology
https://www.readbyqxmd.com/read/27455955/a-multicenter-randomized-open-label-pilot-trial-assessing-the-efficacy-and-safety-of-etanercept-50%C3%A2-mg-twice-weekly-followed-by-etanercept-25%C3%A2-mg-twice-weekly-the-combination-of-etanercept-25%C3%A2-mg-twice-weekly-and-acitretin-and-acitretin-alone-in-patients-with
#6
Joo-Heung Lee, Jai-Il Youn, Tae-Yoon Kim, Jee-Ho Choi, Chul-Jong Park, Yong-Beom Choe, Hae-Jun Song, Nack-In Kim, Kwang-Joong Kim, Jeung-Hoon Lee, Hyun-Jeong Yoo
BACKGROUND: Etanercept, a soluble tumor necrosis factor receptor, and acitretin have been shown to be effective in treating psoriasis. Acitretin is widely used in Korea. However, the combination of etanercept plus acitretin has not been evaluated among Korean patients with psoriasis. The objective of this study was to investigate the efficacy and safety of combination therapy with etanercept and acitretin in patients with moderate to severe plaque psoriasis. METHODS: Sixty patients with psoriasis were randomized to receive etanercept 50 mg twice weekly (BIW) for 12 weeks followed by etanercept 25 mg BIW for 12 weeks (ETN-ETN); etanercept 25 mg BIW plus acitretin 10 mg twice daily (BID) for 24 weeks (ETN-ACT); or acitretin 10 mg BID for 24 weeks (ACT)...
2016: BMC Dermatology
https://www.readbyqxmd.com/read/27405224/patch-testing-in-iranian-children-with-allergic-contact-dermatitis
#7
Hossein Mortazavi, Amirhooshang Ehsani, Seyed Sajed Sajjadi, Nessa Aghazadeh, Ebrahim Arian
BACKGROUND: Allergic contact dermatitis is a common disorder in adults and children alike and appears to be on the increase. The purpose of this study was to determine the sensitization trends in Iranian children with contact dermatitis. METHODS: The result of 109 patch tests performed using the 24 allergens of the European Standard Series in patients below 18 years old from September 2007 to March 2009 were recorded and analyzed. The tests were evaluated at 48 and 72 h after performing...
2016: BMC Dermatology
https://www.readbyqxmd.com/read/27401543/effect-of-12-o-tetradecanoylphorbol-13-acetate-induced-psoriasis-like-skin-lesions-on-systemic-inflammation-and-atherosclerosis-in-hypercholesterolaemic-apolipoprotein-e-deficient-mice
#8
Marie Madsen, Peter Riis Hansen, Lars Bo Nielsen, Karsten Hartvigsen, Anders Elm Pedersen, Jan Pravsgaard Christensen, Annemarie Aarup, Tanja Xenia Pedersen
BACKGROUND: Risk of cardiovascular disease is increased in patients with psoriasis, but molecular mechanisms linking the two conditions have not been clearly established. Lack of appropriate animal models has hampered generation of new knowledge in this area of research and we therefore sought to develop an animal model with combined atherosclerosis and psoriasis-like skin inflammation. METHODS: Topical 12-O-tetradecanoylphorbol-13-acetate (TPA) was applied to the ears twice per week for 8 weeks in atherosclerosis-prone apolipoprotein E deficient (ApoE(-/-)) mice...
2016: BMC Dermatology
https://www.readbyqxmd.com/read/27255181/the-first-danish-family-reported-with-an-aqp5-mutation-presenting-diffuse-non-epidermolytic-palmoplantar-keratoderma-of-bothnian-type-hyperhidrosis-and-frequent-corynebacterium-infections-a-case-report
#9
Anne Bruun Krøigård, Liv Eline Hetland, Ole Clemmensen, Diana C Blaydon, Jens Michael Hertz, Anette Bygum
BACKGROUND: An autosomal dominant form of diffuse non-epidermolytic palmoplantar keratoderma, palmoplantar keratoderma of Bothnian type, is caused by mutations in the AQP5 gene encoding the cell-membrane water channel protein aquaporin 5 leading to defective epidermal-water-barrier function in the epidermis of the palms and soles. CASE PRESENTATION: We report the first Danish family diagnosed with diffuse non-epidermolytic palmoplantar keratoderma of Bothnian type in which fourteen individuals are potentially affected...
2016: BMC Dermatology
https://www.readbyqxmd.com/read/27230291/heat-mediated-reduction-of-apoptosis-in-uvb-damaged-keratinocytes-in-vitro-and-in-human-skin-ex-vivo
#10
Leslie Calapre, Elin S Gray, Sandrine Kurdykowski, Anthony David, Prue Hart, Pascal Descargues, Mel Ziman
BACKGROUND: UV radiation induces significant DNA damage in keratinocytes and is a known risk factor for skin carcinogenesis. However, it has been reported previously that repeated and simultaneous exposure to UV and heat stress increases the rate of cutaneous tumour formation in mice. Since constant exposure to high temperatures and UV are often experienced in the environment, the effects of exposure to UV and heat needs to be clearly addressed in human epidermal cells. METHODS: In this study, we determined the effects of repeated UVB exposure 1 kJ/m(2) followed by heat (39 °C) to human keratinocytes...
2016: BMC Dermatology
https://www.readbyqxmd.com/read/27230122/a-case-of-erythrodermia-from-exacerbated-psoriasis-vulgaris-due-to-treatment-of-acute-hepatitis-c
#11
Eva Lemmenmeier, Barbara Gaus, Patrick Schmid, Matthias Hoffmann
BACKGROUND: Skin side effects during interferon-alpha and ribavirin treatment are common, but autoimmune dermatosis triggered by interferon-alpha is rare. We describe a case of erythrodermia from exacerbated psoriasis during the treatment of acute hepatitis C with pegylated-interferon-alpha and ribavirin. The incidence of psoriasis in this circumstance is unknown and only 36 cases are described in the literature, of which only one describes an erythrodermic psoriasis flare. CASE PRESENTATION: A 50-years old healthy white man presented with the complaints of headache, muscle pain, appetite loss, yellow skin complexion and fatigue...
2016: BMC Dermatology
https://www.readbyqxmd.com/read/27206635/nipple-adenoma-in-a-female-patient-presenting-with-persistent-erythema-of-the-right-nipple-skin-case-report-review-of-the-literature-clinical-implications-and-relevancy-to-health-care-providers-who-evaluate-and-treat-patients-with-dermatologic-conditions-of
#12
Gina P Spohn, Shannon C Trotter, Gary Tozbikian, Stephen P Povoski
BACKGROUND: Nipple adenoma is a very uncommon, benign proliferative process of lactiferous ducts of the nipple. Clinically, it often presents as a palpable nipple nodule, a visible nipple skin erosive lesion, and/or with discharge from the surface of the nipple skin, and is primarily seen in middle-aged women. Resultantly, nipple adenoma can clinically mimic the presentation of mammary Paget's disease of the nipple. The purpose of our current case report is to present a comprehensive review of the available data on nipple adenoma, as well as provide useful information to health care providers (including dermatologists, breast health specialists, and other health care providers) who evaluate patients with dermatologic conditions of the breast skin for appropriately clinically recognizing, diagnosing, and treating patients with nipple adenoma...
2016: BMC Dermatology
https://www.readbyqxmd.com/read/26964878/odonto-onycho-dermal-dysplasia-in-a-patient-homozygous-for-a-wnt10a-nonsense-mutation-and-mild-manifestations-of-ectodermal-dysplasia-in-carriers-of-the-mutation
#13
Anne Bruun Krøigård, Ole Clemmensen, Hans Gjørup, Jens Michael Hertz, Anette Bygum
BACKGROUND: Odonto-onycho-dermal dysplasia (OODD) is a rare form of ectodermal dysplasia characterized by severe oligodontia, onychodysplasia, palmoplantar hyperkeratosis, dry skin, hypotrichosis, and hyperhidrosis of the palms and soles. The ectodermal dysplasias resulting from biallelic mutations in the WNT10A gene result in highly variable phenotypes, ranging from isolated tooth agenesis to OODD and Schöpf-Schulz-Passarge syndrome (SSPS). CASE PRESENTATION: We identified a female patient, with consanguineous parents, who was clinically diagnosed with OODD...
2016: BMC Dermatology
https://www.readbyqxmd.com/read/26790927/estimation-of-individual-cumulative-ultraviolet-exposure-using-a-geographically-adjusted-openly-accessible-tool
#14
Gefei A Zhu, Inbar Raber, Sukolsak Sakshuwong, Shufeng Li, Angela S Li, Caroline Tan, Anne Lynn S Chang
BACKGROUND: Estimates of an individual's cumulative ultraviolet (UV) radiation exposure can be useful since ultraviolet radiation exposure increases skin cancer risk, but a comprehensive tool that is practical for use in the clinic does not currently exist. The objective of this study is to develop a geographically-adjusted tool to systematically estimate an individual's self-reported cumulative UV radiation exposure, investigate the association of these estimates with skin cancer diagnosis, and assess test reliability...
2016: BMC Dermatology
https://www.readbyqxmd.com/read/25778950/bmc-dermatology-reviewer-acknowledgement-2014
#15
Guangde Tu
The editors of BMC Dermatology would like to thank all our reviewers who have contributed their time to the journal in Volume 14 (2014).
December 2015: BMC Dermatology
https://www.readbyqxmd.com/read/25778949/bmc-dermatology-reviewer-acknowledgement-2014
#16
Hayley Henderson
The editors of BMC Dermatology would like to thank all our reviewers who have contributed to the journal in Volume 14 (2014).
December 2015: BMC Dermatology
https://www.readbyqxmd.com/read/26232126/perinatal-probiotic-supplementation-in-the-prevention-of-allergy-related-disease-6%C3%A2-year-follow-up-of-a-randomised-controlled-trial
#17
RANDOMIZED CONTROLLED TRIAL
Melanie Rae Simpson, Christian Kvikne Dotterud, Ola Storrø, Roar Johnsen, Torbjørn Øien
BACKGROUND: Perinatal probiotics supplementation has been shown to be effective in the primary prevention of atopic dermatitis (AD) in early childhood, although the long term effects of probiotics on AD and other allergic diseases is less certain. We have previously reported a significant reduction in the cumulative incidence of AD at 2 years after maternal probiotic supplementation. In this study we present the effects of perinatal probiotics given to women from a general population on allergy related diseases in their offspring at 6 years...
August 1, 2015: BMC Dermatology
https://www.readbyqxmd.com/read/25935520/topical-treatment-with-fresh-human-milk-versus-emollient-on-atopic-eczema-spots-in-young-children-a-small-randomized-split-body-controlled-blinded-pilot-study
#18
RANDOMIZED CONTROLLED TRIAL
Teresa Løvold Berents, Jørgen Rønnevig, Elisabeth Søyland, Peter Gaustad, Gro Nylander, Beate Fossum Løland
BACKGROUND: Public health nurses report on effects of fresh human milk as treatment for conjunctivitis, rhinitis and atopic eczema (AE), the latter being highly prevalent in early childhood. Emollients and topical corticosteroids are first line treatment of AE. As many caregivers have steroid phobia, alternative treatment options for mild AE are of interest. The aim of this small pilot study was to assess the potential effects and risks of applying fresh human milk locally on eczema spots in children with AE...
May 4, 2015: BMC Dermatology
https://www.readbyqxmd.com/read/25886034/photoallergic-reaction-in-a-patient-receiving-vandetanib-for-metastatic-follicular-thyroid-carcinoma-a-case-report
#19
Jennifer Goldstein, Anisha B Patel, Jonathan L Curry, Vivek Subbiah, Sarina Piha-Paul
BACKGROUND: Novel targeted agents have been increasingly developed and tested in clinical trials over the past 5-10 years, many with unknown and unanticipated side effects. We describe here a case of a patient with a history of metastatic follicular thyroid carcinoma that we believe developed vandetanib-associated photoallergic dermatitis while enrolled on a phase 1 clinical trial. CASE PRESENTATION: A 51-year-old Caucasian female with poorly differentiated, metastatic follicular thyroid carcinoma presented with a cutaneous eruption that developed over 3 to 4 days while treated on phase 1 clinical trial with vandetanib-based therapy...
February 13, 2015: BMC Dermatology
https://www.readbyqxmd.com/read/26666633/risk-factors-associated-with-abscess-formation-among-patient-with-leg-erysipelas-cellulitis-in-sub-saharan-africa-a-multicenter-study
#20
MULTICENTER STUDY
Palokinam Vincent Pitché, Bayaki Saka, Ahy Boubacar Diatta, Ousmane Faye, Boh Fanta Diané, Abdoulaye Sangaré, Pascal Niamba, Christine Mandengue, Léon Kobengue, Assane Diop, Fatimata Ly, Mame Thierno Dieng, Alassane Dicko, Maciré Mohamed Soumah, Mohamed Cissé, Sarah Hamdan Kourouma, Isidore Kouassi, Taniratou Boukari, Sefako Akakpo, Dadja Essoya Landoh, Kissem Tchangaï-Walla
BACKGROUND: Abscess formation is a frequent local complication of leg erysipelas. In this study we aimed at identifying factors associated with abscess formation of leg erysipelas in patients in sub-Saharan African countries. METHOD: This is a multicenter prospective study conducted in dermatology units in eight sub-Saharan African countries from October 2013 to September 2014. We performed univariate and multivariate analysis to compare characteristics among the group of patients with leg erysipelas complicated with abscess against those without this complication...
2015: BMC Dermatology
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