journal
MENU ▼
Read by QxMD icon Read
search

BMC Dermatology

journal
https://www.readbyqxmd.com/read/29415699/can-an-app-supporting-psoriasis-patients-improve-adherence-to-topical-treatment-a-single-blind-randomized-controlled-trial
#1
Mathias Tiedemann Svendsen, Flemming Andersen, Kirsten Hammond Andersen, Klaus Ejner Andersen
BACKGROUND: Topical corticosteroid or corticosteroid/calcipotriol preparations are recommended first-line topical treatments of psoriasis, but a main cause for the lack of efficacy of topical treatments is considered low rates of adherence to topical drugs. Patient support by the use of applications (apps) for smartphones is suggested to improve medical adherence. METHODS/DESIGN: Design: An investigator-initiated, single-center, single-blind, parallel-group, phase-4 clinical superiority randomized controlled trial (RCT)...
February 7, 2018: BMC Dermatology
https://www.readbyqxmd.com/read/29415693/elucidating-mechanistic-insights-into-drug-action-for-atopic-dermatitis-a-systems-biology-approach
#2
Indhupriya Subramanian, Vivek K Singh, Abhay Jere
BACKGROUND: Topical Betamethasone (BM) and Pimecrolimus (PC) are widely used drugs in the treatment of atopic dermatitis (AD). Though the biomolecules and biological pathways affected by the drugs are known, the causal inter-relationships among these pathways in the context of skin is not available. We aim to derive this insight by using transcriptomic data of AD skin samples treated with BM and PC using systems biology approach. METHODS: Transcriptomic datasets of 10 AD patients treated with Betamethasone and Pimecrolimus were obtained from GEO datasets...
February 7, 2018: BMC Dermatology
https://www.readbyqxmd.com/read/29352809/a-novel-plec-nonsense-homozygous-mutation-c-7159g%C3%A2-%C3%A2-t-p-glu2387-causes-epidermolysis-bullosa-simplex-with-muscular-dystrophy-and-diffuse-alopecia-a-case-report
#3
Zoe Argyropoulou, Lu Liu, Linda Ozoemena, Claudia C Branco, Raquel Senra, Ângela Reis-Rego, Luisa Mota-Vieira
BACKGROUND: Epidermolysis bullosa simplex with muscular dystrophy (EBS-MD; OMIM #226670) is an autosomal recessive disease, characterized mainly by skin blistering at birth or shortly thereafter, progressive muscle weakness, and rarely by alopecia. EBS-MD is caused by mutations in the PLEC gene (OMIM *601282), which encodes plectin, a structural protein expressed in several tissues, including epithelia and muscle. We describe a patient affected with EBS-MD and diffuse alopecia in which we identified a novel pathogenic mutation by PCR amplification of all coding exons and exon-intron boundaries of PLEC gene, followed by bidirectional Sanger sequencing...
January 20, 2018: BMC Dermatology
https://www.readbyqxmd.com/read/29262820/a-case-report-of-erythroderma-in-a-patient-with-borderline-leprosy-on-reversal-reaction-a-result-of-the-exacerbated-reaction
#4
Denis Miyashiro, Ana Paula Vieira, Maria Angela Bianconcini Trindade, João Avancini, José Antonio Sanches, Gil Benard
BACKGROUND: Erythroderma is characterized by erythema and scaling affecting more than 90% of the body surface area. Inflammatory, neoplastic and, more rarely, infectious diseases may culminate with erythroderma. Diagnosis of the underlying disorder is therefore crucial to institute the appropriate therapy. Leprosy is a chronic infectious disease that is endemic in Brazil. Here we present an unusual case of leprosy and reversal reaction causing erythroderma, and we discuss the underlying immunological mechanisms which could contribute to the generalized skin inflammation...
December 20, 2017: BMC Dermatology
https://www.readbyqxmd.com/read/29233122/composite-hemangioendothelioma-of-the-forehead-and-right-eye-a-case-report
#5
Ghasem Rahmatpour Rokni, Fatemeh Montazer, Mahnaz Sharifian, Mohamad Goldust
BACKGROUND: Hemangioendothelioma includes several types of vascular neoplasms , as well as both benign and malignant growth. CASE PRESENTATION: This study evaluated a case of a 78-year-old female diagnosed with composite hemangioendothelioma (CHE). This patient had an 18-month history of painless inflammatory lesions and erythema on the left forehead and right upper eyelid. The clinical and pathologic characteristics of the CHE were evaluated in the present study...
December 12, 2017: BMC Dermatology
https://www.readbyqxmd.com/read/29183309/assessment-of-the-effects-of-skin-microneedling-as-adjuvant-therapy-for-facial-melasma-a-pilot-study
#6
Emerson V A Lima, Mariana Modesto D A Lima, Mauricio Pedreira Paixão, Hélio Amante Miot
BACKGROUND: Melasma is a common chronic and relapsing acquired dyschromia. Skin microneedling was reported resulting sustained long-term improvement of recalcitrant melasma, however, the exact mechanism that promotes this skin lightening is not known. This study aimed to investigate clinical and histologic alterations promoted by skin microneedling in facial melasma. METHODS: Open pilot trial including six women with facial refractory melasma submitted to two sessions of microneedling (1...
November 28, 2017: BMC Dermatology
https://www.readbyqxmd.com/read/29166932/bap1-case-report-and-insight-into-a-novel-tumor-suppressor
#7
Kanad Ghosh, Badri Modi, William D James, Brian C Capell
BACKGROUND: BRCA1-Associated-Protein 1 (BAP1) is a dynamic tumor suppressor which, when mutated, has been associated with an increased risk of uveal melanoma, cutaneous melanoma, mesothelioma, and several other cancers. Germline BAP1 mutations have been extensively studied, where they have been found to cause hereditary cancer susceptibility. However, their sporadic counterparts, tumors that display a loss of BAP1 expression due to somatically arising mutations in the BAP1 gene, remain a poorly described entity...
November 22, 2017: BMC Dermatology
https://www.readbyqxmd.com/read/29070025/daylight-photodynamic-therapy-versus-cryosurgery-for-the-treatment-and-prophylaxis-of-actinic-keratoses-of-the-face%C3%A2-%C3%A2-protocol-of-a-multicenter-prospective-randomized-controlled-two-armed-study
#8
E Kohl, M Koller, F Zeman, R-M Szeimies, W G Philipp-Dormston, W Prager, P A Gerber, S Karrer
BACKGROUND: Photodynamic therapy with daylight (DL-PDT) is efficacious in treating actinic keratosis (AK), but the efficacy of field-directed, repetitive DL-PDT for the treatment and prophylaxis of AK in photodamaged facial skin has not yet been investigated. METHODS/DESIGN: In this multicenter, prospective, randomized, controlled, two-armed, observer-blinded trial, patients with a minimum of 5 mild-to-moderate AK lesions on photodamaged facial skin are randomly allocated to two treatment groups: DL-PDT with methyl aminolevulinate (MAL) and cryosurgery...
October 25, 2017: BMC Dermatology
https://www.readbyqxmd.com/read/28814312/rationale-and-design-of-the-brigham-cohort-for-psoriasis-and-psoriatic-arthritis-registry-coppar
#9
Maria Schneeweiss, Joseph F Merola, Elizabeth W Karlson, Daniel H Solomon
BACKGROUND: Psoriasis (PsO) and psoriatic arthritis (PsA) are related conditions with poorly defined transition among them, risk factors for progression, complex treatment algorithms, and biomarkers for treatment response and long-term outcomes. We describe the development of a PsO/PsA registry at an academic medical center. METHODS: We developed a single-center PsO/PsA longitudinal disease registry including biorepository that captures relevant disease markers and treatment choices in a circumscribed population with a defined catchment area...
August 16, 2017: BMC Dermatology
https://www.readbyqxmd.com/read/28738799/prevalence-of-head-lice-infestation-and-pediculicidal-effect-of-permethrine-shampoo-in-primary-school-girls-in-a-low-income-area-in-southeast-of-iran
#10
Moussa Soleimani-Ahmadi, Seyed Aghil Jaberhashemi, Mehdi Zare, Alireza Sanei-Dehkordi
BACKGROUND: Head lice infestation is a common public health problem that is most prevalent in primary school children throughout the world, especially in developing countries including different parts of Iran. This study aimed to determine the prevalence and risk factors associated with head lice infestation and pediculicidal effect of 1% permethrin shampoo in primary schools girls of Bashagard County, one of the low socioeconomic areas in southeast of Iran. METHODS: In this interventional study six villages with similar demographical situations were selected and randomly assigned into intervention and control areas...
July 24, 2017: BMC Dermatology
https://www.readbyqxmd.com/read/28668077/variation-of-mutant-allele-frequency-in-nras-q61-mutated-melanomas
#11
Zofia Hélias-Rodzewicz, Elisa Funck-Brentano, Nathalie Terrones, Alain Beauchet, Ute Zimmermann, Cristi Marin, Philippe Saiag, Jean-François Emile
BACKGROUND: Somatic mutations of BRAF or NRAS activating the MAP kinase cell signaling pathway are present in 70% of cutaneous melanomas. The mutant allele frequency of BRAF V600E (M%BRAF) was recently shown to be highly heterogeneous in melanomas. The present study focuses on the NRAS Q61 mutant allele frequency (M%NRAS). METHODS: Retrospective quantitative analyze of 104 NRAS mutated melanomas was performed using pyrosequencing. Mechanisms of M%NRAS imbalance were studied by fluorescence in situ hybridization (FISH) and microsatellite analysis...
July 1, 2017: BMC Dermatology
https://www.readbyqxmd.com/read/28601088/sirt1-activation-mediates-heat-induced-survival-of-uvb-damaged-keratinocytes
#12
Leslie Calapre, Elin S Gray, Sandrine Kurdykowski, Anthony David, Pascal Descargues, Mel Ziman
BACKGROUND: Exposure to heat stress after UVB irradiation induces a reduction of apoptosis, resulting in survival of DNA damaged human keratinocytes. This heat-mediated evasion of apoptosis appears to be mediated by activation of SIRT1 and inactivation of p53 signalling. In this study, we assessed the role of SIRT1 in the inactivation of p53 signalling and impairment of DNA damage response in UVB plus heat exposed keratinocytes. RESULTS: Activation of SIRT1 after multiple UVB plus heat exposures resulted in increased p53 deacetylation at K382, which is known to affect its binding to specific target genes...
June 10, 2017: BMC Dermatology
https://www.readbyqxmd.com/read/28521835/adult-autoimmune-enteropathy-presenting-initially-with-acquired-acrodermatitis-enteropathica-a-case-report
#13
Erina Lie, Sarah Sung, Steven Hoseong Yang
BACKGROUND: Acrodermatitis enteropathica (AE) is a rare dermatitis secondary to zinc deficiency most commonly seen as an inherited disease in infants. In the last decade, increased number of reports have been published on the acquired form that presents in adulthood. Unlike its inherited counterpart, acquired AE (AAE) is often secondary to underlying pathologic or iatrogenic etiologies that interfere with nutritional absorption, such as inflammatory bowel disease or alcoholism. Various gastrointestinal pathologies have been associated with AAE, but there is currently no report on its association with adult autoimmune enteropathy (AIE), a rare gastrointestinal disorder commonly seen in infants, with limited cases reported in adults...
May 18, 2017: BMC Dermatology
https://www.readbyqxmd.com/read/28482858/tight-controlled-dose-reduction-of-biologics-in-psoriasis-patients-with-low-disease-activity-a-randomized-pragmatic-non-inferiority-trial
#14
Selma Atalay, Juul M P A van den Reek, Lieke J van Vugt, Marisol E Otero, Peter C M van de Kerkhof, Alfons A den Broeder, Wietske Kievit, Elke M G J de Jong
BACKGROUND: Psoriasis is an immune-mediated chronic inflammatory skin disorder for which several targeted biologic therapies became available in the last 10 years. Data from patients with rheumatoid arthritis revealed that dose tapering combined with tight control of disease activity is successful. For psoriasis patients the lowest effective dose of biologics needs to be determined. The objective was to assess whether dose tapering of biologics guided by Psoriasis Area and Severity Index (PASI) and Dermatology Quality of Life Index (DLQI) scores in psoriasis patients with controlled disease activity is non-inferior (NI) to usual care...
May 8, 2017: BMC Dermatology
https://www.readbyqxmd.com/read/28468620/evaluation-of-therapeutic-potential-of-vb-001-a-leave-on-formulation-for-the-treatment-of-moderate-adherent-dandruff
#15
Anamika Bhattacharyya, Nilu Jain, Sudhanand Prasad, Shilpi Jain, Vishal Yadav, Shamik Ghosh, Shiladitya Sengupta
BACKGROUND: Dandruff is a common scalp condition characterized by excessive scaling and itch. Aberrant colonization of the scalp by commensal Malassezia spp. is a major contributor in the multifactorial etiology of dandruff. Literature based understanding of Malassezia linked pathophysiology of dandruff allowed us to comprehend a strategy to potentiate the efficacy of a known antifungal agent used in dandruff therapy. The aim of this study was to determine the efficacy and skin safety of VB-001 antidandruff leave-on formulation in comparison with marketed antidandruff ZPTO shampoo in patients with moderate adherent dandruff of the scalp...
May 3, 2017: BMC Dermatology
https://www.readbyqxmd.com/read/28320360/a-prospective-analysis-of-pinch-grafting-of-chronic-leg-ulcers-in-a-series-of-elderly-patients-in-rural-cameroon
#16
Benjamin Momo Kadia, Christian Akem Dimala, Desmond Aroke, Cyril Jabea Ekabe, Reine Suzanne Mengue Kadia, Alain Chichom Mefire
BACKGROUND: Chronic leg ulcers (CLUs) pose serious public health concerns worldwide. They mainly affect the elderly population. Pinch grafting (PG) could be used to treat a variety of CLUs. However, in Cameroon, there is scarce data on the outcome of PG of CLUs in elderly patients in rural hospitals where most of these patients seek for medical attention and where clinicians rely on unconventional wound dressing methods to treat CLUs. Our objective was to describe the outcome of PG of CLUs in elderly patients in rural Cameroon...
March 20, 2017: BMC Dermatology
https://www.readbyqxmd.com/read/28228108/expression-profiling-and-bioinformatic-analyses-suggest-new-target-genes-and-pathways-for-human-hair-follicle-related-micrornas
#17
Lara M Hochfeld, Thomas Anhalt, Céline S Reinbold, Marisol Herrera-Rivero, Nadine Fricker, Markus M Nöthen, Stefanie Heilmann-Heimbach
BACKGROUND: Human hair follicle (HF) cycling is characterised by the tight orchestration and regulation of signalling cascades. Research shows that micro(mi)RNAs are potent regulators of these pathways. However, knowledge of the expression of miRNAs and their target genes and pathways in the human HF is limited. The objective of this study was to improve understanding of the role of miRNAs and their regulatory interactions in the human HF. METHODS: Expression levels of ten candidate miRNAs with reported functions in hair biology were assessed in HFs from 25 healthy male donors...
February 22, 2017: BMC Dermatology
https://www.readbyqxmd.com/read/28212650/skin-cancer-knowledge-and-attitudes-in-the-region-of-fez-morocco-a-cross-sectional-study
#18
Awatef Kelati, Hanane Baybay, Mariam Atassi, Samira Elfakir, Salim Gallouj, Mariame Meziane, Fatima Zahra Mernissi
BACKGROUND: The prevalence of skin cancers is constantly increasing in Morocco, and they have gradually become more aggressive due to a significant delay in the diagnosis. Our aim was to assess the levels of awareness and the influencing factors related to skin cancer knowledge in Morocco. METHODS: This cross-sectional study was carried out in Morocco through the medium of a validated questionnaire, which contained several items - demographics, skin cancer knowledge and attitudes towards skin cancer patients- during a period of 1 year (2014)...
February 17, 2017: BMC Dermatology
https://www.readbyqxmd.com/read/28209147/knowledge-attitudes-and-practices-of-the-medical-personnel-regarding-atopic-dermatitis-in-yaound%C3%A3-cameroon
#19
Emmanuel Armand Kouotou, Jobert Richie N Nansseu, Alexandra Dominique Ngangue Engome, Sandra Ayuk Tatah, Anne Cécile Zoung-Kanyi Bissek
BACKGROUND: Atopic dermatitis (AD) is a chronic, relapsing and pruritic inflammatory skin disease whose management remains unclear to most non-dermatologists. This study aimed to assess the knowledge, attitudes and practices (KAP) of the medical staff regarding AD in Yaoundé, Cameroon. METHODS: This was a cross-sectional study conducted from January to April 2014 in 20 health facilities located in Yaoundé, the capital city of Cameroon. All medical staff who provided their consent were included in the study...
February 16, 2017: BMC Dermatology
https://www.readbyqxmd.com/read/27716172/treatment-of-plaque-psoriasis-with-an-ointment-formulation-of-the-janus-kinase-inhibitor-tofacitinib-a-phase-2b-randomized-clinical-trial
#20
RANDOMIZED CONTROLLED TRIAL
Kim A Papp, Robert Bissonnette, Melinda Gooderham, Steven R Feldman, Lars Iversen, Jennifer Soung, Zoe Draelos, Carla Mamolo, Vivek Purohit, Cunshan Wang, William C Ports
BACKGROUND: Most psoriasis patients have mild to moderate disease, commonly treated topically. Current topical agents have limited efficacy and undesirable side effects associated with long-term use. Tofacitinib is a small molecule Janus kinase inhibitor investigated for the topical treatment of psoriasis. METHODS: This was a 12-week, randomized, double-blind, parallel-group, vehicle-controlled Phase 2b study of tofacitinib ointment (2 % and 1 %) applied once (QD) or twice (BID) daily in adults with mild to moderate plaque psoriasis...
October 3, 2016: BMC Dermatology
journal
journal
36181
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"