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BMC Cardiovascular Disorders

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https://www.readbyqxmd.com/read/28535761/the-emerging-role-of-cardiovascular-magnetic-resonance-in-the-evaluation-of-hypertensive-heart-disease
#1
REVIEW
Sophie Mavrogeni, Vasiliki Katsi, Vasiliki Vartela, Michel Noutsias, George Markousis-Mavrogenis, Genovefa Kolovou, Athanasios Manolis
BACKGROUND: Arterial hypertension is the commonest cause of cardiovascular death. It may lead to hypertensive heart disease (HHD), including heart failure (HF), ischemic heart disease (IHD) and left ventricular hypertrophy (LVH). MAIN BODY: According to the 2007 ESH/ESC guidelines, the recommended imaging technique is echocardiography (echo), when a more sensitive detection of LVH than that provided by ECG, is needed. Cardiovascular Magnetic Resonance (CMR), a non-invasive, non-radiating technique, offers the following advantages, beyond echo: a) more reliable and reproducible measurements of cardiac parameters such as volumes, ejection fraction and cardiac mass b) more accurate differentiation of LVH etiology by providing information about tissue characterisation c) more accurate evaluation of myocardial ischemia, specifically if small vessels disease is present d) technique of choice for diagnosis of renovascular, aortic tree/branches lesions and quantification of aortic valve regurgitation e) technique of choice for treatment evaluation in clinical trials...
May 23, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28532506/clinical-evaluation-of-myocardial-involvement-in-acute-myopericarditis-in-young-adults
#2
Ersin Saricam, Yasemin Saglam, Tuncay Hazirolan
BACKGROUND: Myocardial involvement in young adults has various causes. Acute myopericarditis is one of the myocardial involvements in young adults. It is easy to confuse with acute ST-elevation myocardial infarction because of the electrocardiographic features. This study aims to investigate a number of imaging techniques and clinical features for acute myopericarditis in young adults (<30 years of age). METHODS: This retrospective study included 147 patients selected from the 2147 patients at the age of <30 with acute chest pain admitted into emergency service between 2010 and 2016...
May 22, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28532430/a-retrospective-cohort-study-on-the-risk-of-stroke-in-relation-to-a-priori-health-knowledge-level-among-people-with-type-2-diabetes-mellitus-in-taiwan
#3
Yun-Ju Lai, Hsiao-Yun Hu, Ya-Ling Lee, Po-Wen Ku, Yung-Feng Yen, Dachen Chu
BACKGROUND: Intervention of diabetes care education with regular laboratory check-up in outpatient visits showed long-term benefits to reduce the risk of macrovascular complications among people with type 2 diabetes. However, research on the level of a priori health knowledge to the prevention of diabetic complications in community settings has been scarce. We therefore aimed to investigate the association of health knowledge and stroke incidence in patients with type 2 diabetes in Taiwan...
May 22, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28532389/the-use-of-macitentan-in-fontan-circulation-a-case-report
#4
Polyvios Demetriades, Amir Aziz, Robin Condliffe, Sarah E Bowater, Paul F Clift
BACKGROUND: The Fontan circulation, a result of a palliative procedure in patients with single systemic ventricles, is defined by chronically elevated pulmonary vascular resistance. When traditional heart failure therapies fail, pharmacological agents that reduce pulmonary artery pressures may be used. These include endothelial-receptor antagonists, prostanoids and phosphodiesterase type 5 inhibitors. We report the first use of macitentan, an endothelin-receptor antagonist, in a patient with a Fontan circulation...
May 22, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28525971/left-ventricular-mural-thrombus-and-dual-coronary-embolization-associated-with-hyperthyroid-cardiomyopathy-and-atrial-fibrillation-a-case-report
#5
Guohui Liu, Ping Yang, Yuquan He
BACKGROUND: The majority of acute myocardial infarction (AMI) events are caused by thrombotic occlusion of the coronary artery, secondary to atherosclerotic plaque erosion or rupture. However, coronary embolism (CE), while rare, is being increasingly recognized as an important cause of AMI. We present the case of a patient with multi-site coronary artery embolization associated with hyperthyroid-related cardiomyopathy and atrial fibrillation. CASE PRESENTATION: A 49-year-old female with a history of hyperthyroidism and atrial fibrillation (AF) was admitted to our hospital presenting with right upper limb pain and swelling...
May 19, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28521773/red-yeast-rice-induces-less-muscle-fatigue-symptom-than-simvastatin-in-dyslipidemic-patients-a-single-center-randomized-pilot-trial
#6
Yangjing Xue, Luyuan Tao, Shaoze Wu, Guoqiang Wang, Lu Qian, Jiwu Li, Lianming Liao, Jifei Tang, Kangting Ji
BACKGROUND: About 10-15% patients who take statins experience skeletal muscle problems. Red yeast rice has a good safety profile could provide a compromise therapeutic strategy. Therefore, the aim of this study was to evaluate the effects of red yeast rice, when compared to simvastatin, on the muscle fatigue symptom and the serum lipid level in dyslipidemic patients with low to moderate cardiovascular risk. METHODS: A total of 60 dyslipidemic patients with low to moderate cardiovascular risk were recruited and randomly assigned to receive either simvastatin (n = 33) or red yeast rice (n = 27) for 4 weeks...
May 18, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28514967/at1-receptor-response-to-non-saturating-ang-ii-concentrations-is-amplified-by-calcium-channel-blockers
#7
Kristoffer Bernhem, Kalaiselvan Krishnan, Alexander Bondar, Hjalmar Brismar, Anita Aperia, Lena Scott
BACKGROUND: Blockers of angiotensin II type 1 receptor (AT1R) and the voltage gated calcium channel 1.2 (CaV1.2) are commonly used for treatment of hypertension. Yet there is little information about the effect of physiological concentrations of angiotensin II (AngII) on AT1R signaling and whether there is a reciprocal regulation of AT1R signaling by CaV1.2. METHODS: To elucidate these questions, we have studied the Ca(2+) signaling response to physiological and pharmacological AngII doses in HEK293a cells, vascular smooth muscle cells and cardiomyocytes using a Ca(2+) sensitive dye as the principal sensor...
May 17, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28511669/fasting-levels-of-growth-hormone-are-associated-with-carotid-intima-media-thickness-but-are-not-affected-by-fluvastatin-treatment
#8
Erik Hallengren, Peter Almgren, Maria Rosvall, Gerd Östling, Margaretha Persson, Andreas Bergmann, Joachim Struck, Gunnar Engström, Bo Hedblad, Olle Melander
BACKGROUND: Growth hormone (GH) has been linked to cardiovascular disease but the exact mechanism of this association is still unclear. We here test if the fasting levels of GH are cross-sectionally associated with carotid intima media thickness (IMT) and whether treatment with fluvastatin affects the fasting level of GH. METHODS: We examined the association between GH and IMT in 4425 individuals (aged 46-68 years) included in the baseline examination (1991-1994) of the Malmö Diet and Cancer cardiovascular cohort (MDC-CC)...
May 16, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28506218/investigation-of-the-pathophysiology-of-cardiopulmonary-bypass-using-rodent-extracorporeal-life-support-model
#9
Ru-Wen Chang, Chien-Ming Luo, Hsi-Yu Yu, Yih-Sharng Chen, Chih-Hsien Wang
BACKGROUND: Extracorporeal life support (ECLS) systems are life-saving devices used for treating patients with severe cardiopulmonary failure. In this study, we implemented a rat model of ECLS without the administration of inotropes or vasopressors. METHODS: The rats underwent 5 min of untreated asphyxial cardiac arrest and were resuscitated by ECLS for 30 min. The right external jugular vein and right femoral artery were separately cannulated to the ECLS outflow and inflow, respectively...
May 15, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28506214/origins-location-of-the-outflow-tract-ventricular-arrhythmias-exhibiting-qrs-pattern-or-qs-pattern-with-a-notch-on-the-descending-limb-in-lead-v1
#10
Cong Lin, Cheng Zheng, De-Pu Zhou, Xiao-Wei Li, Shu-Jie Wu, Jia-Feng Lin
BACKGROUND: Ventricular outflow tract(VOT) ventricular arrhythmias(VAs) presenting qrS pattern or QS pattern with a notch on the descending limb in lead V1 were consistently thought of arising from the commissure between left and right coronary cusp (L-RCC) by previous studies. However, we found they could originate from other anatomic structures in VOT. This study aimed to investigate the exact origin of this kind VAs. METHODS: Forty-nine patients of VOT premature ventricular contrations/ventricular tachycardia(PVCs/VT) with lead V1 presenting qrS pattern or QS pattern with a notch on the descending limb undergoing successful radiofrequency catheter ablation(RFCA) in our center were analyzed...
May 15, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28490326/the-clinical-epidemiology-of-fatigue-in-newly-diagnosed-heart-failure
#11
Brent A Williams
BACKGROUND: Fatigue is a common and distressing but poorly understood symptom among patients with heart failure (HF). This study sought to evaluate the prevalence, predictors, and prognostic value of clinically documented fatigue in newly diagnosed HF patients from the community. METHODS: This retrospective cohort study consisted of 12,285 newly diagnosed HF patients receiving health care services through the Geisinger Health System, with passive data collection through electronic medical records (EMR)...
May 11, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28490380/living-with-hypertrophic-cardiomyopathy-and-an-implantable-defibrillator
#12
Peter Magnusson, Jessica Jonsson, Stellan Mörner, Lennart Fredriksson
BACKGROUND: ICDs efficiently terminate life-threatening arrhythmias, but complications occur during long-term follow-up. Patients' own perspective is largely unknown. The aim of the study was to describe experiences of hypertrophic cardiomyopathy (HCM) patients with implantable defibrillators (ICDs). METHODS: We analyzed 26 Swedish patient interviews using hermeneutics and latent content analysis. RESULTS: Patients (aged 27-76 years) were limited by HCM especially if it deteriorates into heart failure...
May 10, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28490354/dual-time-point-myocardial-18-f-fdg-imaging-in-the-detection-of-coronary-artery-disease
#13
Ke-Fei Dou, Xiao-Jin Gao, Bo-Qia Xie, Yan Li, Zuo-Xiang He, Min-Fu Yang
BACKGROUND: Myocardial (18)F-deoxyglucose ((18)F-FDG) uptake has been observed to be enhanced in patients with coronary artery disease (CAD) under fasting conditions. However, whether the increased (18)F-FDG is induced by myocardial ischemia and how to discriminate ischemic from physiological (18)F-FDG uptake have rarely been investigated. METHODS: Under fasting conditions, (18)F-FDG PET imaging was performed in 52 patients with suspected CAD. Two (18)F-FDG imaging sessions were conducted within two hours after a single administration of (18)F-FDG (dual-time-point imaging), and with an intervention of an exercise test after the first imaging...
May 10, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28486954/mir-486-regulates-cardiomyocyte-apoptosis-by-p53-mediated-bcl-2-associated-mitochondrial-apoptotic-pathway
#14
Yuhan Sun, Qiang Su, Lang Li, Xiantao Wang, Yuanxi Lu, Jiabao Liang
BACKGROUND: Cardiomyocyte apoptosis is a common pathological manifestation that occurs in several heart diseases. This study aimed to explore the mechanism of microRNA-486 (miR-486) in cardiomyocyte apoptosis by interfering with the p53-activated BCL-2 associated mitochondrial pathway. METHODS: miR-486 mimics and inhibitors were transfected into the primary cardiomyocytes of suckling Sprague-Dawley rat pups, and H2O2 was used to induce apoptosis. Flow cytometry and TUNEL were both used to detect cardiomyocyte apoptosis, while the relative mRNA transcript and protein levels of miR-486, p53, Bbc3, BCL-2, and cleaved caspase-3 were detected using RT-PCR and western blot analysis, respectively...
May 10, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28486936/effects-of-inaccuracies-in-arterial-path-length-measurement-on-differences-in-mri-and-tonometry-measured-pulse-wave-velocity
#15
Jonathan R Weir-McCall, Faisel Khan, Deirdre B Cassidy, Arsh Thakur, Jennifer Summersgill, Shona Z Matthew, Fiona Adams, Fiona Dove, Stephen J Gandy, Helen M Colhoun, Jill Jf Belch, J Graeme Houston
BACKGROUND: Carotid-femoral pulse wave velocity (cf-PWV) and aortic PWV measured using MRI (MRI-PWV) show good correlation, but with a significant and consistent bias across studies. The aim of the current study was to evaluate whether the differences between cf.-PWV and MRI-PWV can be accounted for by inaccuracies of currently used distance measurements. METHODS: One hundred fourteen study participants were recruited into one of 4 groups: Type 2 diabetes melltus (T2DM) with cardiovascular disease (CVD) (n = 23), T2DM without CVD (n = 41), CVD without T2DM (n = 25) and a control group (n = 25)...
May 10, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28482853/dramatic-and-early-response-to-low-dose-steroid-in-the-treatment-of-acute-eosinophilic-myocarditis-a-case-report
#16
Yu-Wei Chen, Yu-Cheng Chang, Chieh-Shou Su, Wei-Chun Chang, Wen-Lieng Lee, Chih-Hung Lai
BACKGROUND: Eosinophilic myocarditis encompasses a variety of etiologies and the prognosis varies. For patients with a hypersensitive response to medications, high-dose corticosteroids and discontinuation of culprit medications are the main treatments. CASE PRESENTATION: We reported a young man with biopsy-proven eosinophilic myocarditis which was possibly induced by Chinese herbal medicine. His heart failure and left ventricular hypertrophy improved soon after low-dose corticosteroid...
May 8, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28482820/the-changing-epidemiology-and-clinical-features-of-infective-endocarditis-a-retrospective-study-of-196-episodes-in-a-teaching-hospital-in-china
#17
Wan Zhu, Qian Zhang, Jingping Zhang
BACKGROUND: Infective endocarditis is an uncommon but life-threatening infectious disease. To our knowledge, current investigations of the characteristics of infective endocarditis in our region are scarce. In this study, we aimed to investigate the changes in the epidemiology and clinical features of infective endocarditis. METHODS: A retrospective analysis of clinical data was performed using 196 infective endocarditis cases diagnosed between June 2004 and December 2012 at The First Affiliated Hospital of China Medical University...
May 8, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28482816/the-role-of-vaspin-as-a-predictor-of-coronary-angiography-result-in-scad-stable-coronary-artery-disease-patients
#18
Matej Stančík, Ivana Ságová, Ema Kantorová, Marián Mokáň
BACKGROUND: The role of vaspin in the pathogenesis of stable coronary artery disease (SCAD) have been repeatedly addressed in clinical studies. However, from the point of view of clinical practice, the results of earlier studies are still inconclusive. METHODS: The data of 106 SCAD patients who received coronary angiography and 85 coronary artery disease-free controls were collected and analysed. The patients were divided into subgroups according to their pre-test probability (PTP) and according to the result of coronary angiography...
May 8, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28482815/hypertension-in-cameroon-associated-with-high-likelihood-of-obstructive-sleep-apnea-a-pilot-study
#19
Alfred Kongnyu Njamnshi, Michel Karngong Mengnjo, Eta Ngole Mbong, Samuel Kingue, Julius Yundze Fonsah, Andreas Ateke Njoh, Leonard Njamnshi Nfor, Leonard Ngarka, Samuel Eric Chokote, Felicien Enyime Ntone
BACKGROUND: Although disordered sleep patterns predispose to hypertension (HTN), little is known on the effect of the latter on sleep patterns in sub-Saharan Africa. This study therefore sought to generate preliminary data on the likelihood (risk) of Obstructive sleep apnea (OSA) in hypertensive patients, with the aid of sleep questionnaires. METHODS: This case-control study, age-and-sex-matched HTN patients with normotensive participants, and compared sleep patterns in either group determined with the aid of the Berlin Questionnaire (BQ) and Epworth Sleepiness Scale (ESS)...
May 8, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28482812/very-early-recurrence-predicts-long-term-outcome-in-patients-after-atrial-fibrillation-catheter-ablation-a-prospective-study
#20
Yangjing Xue, Xiaoning Wang, Saroj Thapa, Luping Wang, Jiaoni Wang, Zhiqiang Xu, Shaoze Wu, Luyuan Tao, Guoqiang Wang, Lu Qian, Lianming Liao, Baohua Liu, Kangting Ji
BACKGROUND: Long-term recurrence (LR) is a tendency that re-occurs within 3 months after catheter ablation for atrial fibrillation (AF). Whether very early recurrence (VER) within 7 days of post ablation is a prognostic factor of LR or not is unclear. For this reason, present study sought to examine the relationship between VER and LR. METHODS: In this prospective analysis 378 consecutive patients underwent an initial catheter ablation for paroxysmal or persistent AF...
May 8, 2017: BMC Cardiovascular Disorders
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