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BMC Cardiovascular Disorders

Jiang Wang, Gang Wang, Xiao Bi, Ran Zhang, Changfu Liu
BACKGROUND: The crista terminalis is a variation of normal anatomical structure within the right atrium which may be misdiagnosed with an abnormal atrial mass normally visualized in the standard views on the transthoracic echocardiogram. CASE PRESENTATION: In this case presentation, we demonstrated a rare case report describing the accidental discovery of a right atrial mass-like structure in a 54-year old Asian man without physical discomfort during an echocardiographic examination...
November 7, 2018: BMC Cardiovascular Disorders
Julian W E Jarman, Wajid Hussain, Tom Wong, Vias Markides, Jamie March, Laura Goldstein, Ray Liao, Iftekhar Kalsekar, Abhishek Chitnis, Rahul Khanna
BACKGROUND: The objective of our study was to compare resource use and clinical outcomes among atrial fibrillation (AF) patients who underwent catheter ablation versus antiarrhythmic drug (AAD) treatment. METHODS: A retrospective cohort design using the Clinical Practice Research Data-Hospital Episode Statistics linkage data from England (2008-2013) was used. Patients undergoing catheter ablation treatment for AF were indexed to the date of first procedure. AAD patients with at least two different AAD drugs were indexed to the first fill of the second AAD...
November 7, 2018: BMC Cardiovascular Disorders
Nele Laleman, Séverine Henrard, Marjan van den Akker, Geert Goderis, Frank Buntinx, Gijs Van Pottelbergh, Bert Vaes
BACKGROUND: The current study evaluated time trends of statin use and incidence of recurrent CVD in secondary prevention from 1999 to 2013 and investigated which factors were associated with statin use in secondary prevention. METHODS: Intego is a primary care registration network with 111 general practitioners working in 48 practices in Flanders, Belgium. This retrospective registry-based study included patients aged 50 years or older with a history of CVD. The time trends of statin use and incidence of recurrent CVD in secondary prevention were determined by using a joinpoint regression analysis...
November 6, 2018: BMC Cardiovascular Disorders
Wilby Williamson, Odaro J Huckstep, Eleni Frangou, Afifah Mohamed, Cheryl Tan, Maryam Alsharqi, Mariane Bertagnolli, Winok Lapidaire, Julia Newton, Henner Hanssen, Richard McManus, Helen Dawes, Charlie Foster, Adam J Lewandowski, Paul Leeson
BACKGROUND: Hypertension prevalence in young adults has increased and is associated with increased incidence of cerebrovascular and cardiovascular events in middle age. However, there is significant debate regards how to effectively manage young adult hypertension with recommendation to target lifestyle intervention. Surprisingly, no trials have investigated whether lifestyle advice developed for blood pressure control in older adults is effective in these younger populations. METHODS/DESIGN: TEPHRA is an open label, parallel arm, randomised controlled trial in young adults with high normal and elevated blood pressure...
November 6, 2018: BMC Cardiovascular Disorders
Hongwei Tian, Jingang Cui, Chengzhi Yang, Fenghuan Hu, Jiansong Yuan, Shengwen Liu, Weixian Yang, Xiaowei Jiang, Shubin Qiao
BACKGROUND: Atrial fibrillation (AF) is the most common complication in hypertrophic cardiomyopathy (HCM). The mechanisms of AF is associated with left atrial (LA) structural remodeling in HCM patients. However, the impact of left ventricular (LV) remodeling on the presence of AF in HCM patients has not been evaluated yet. We sought to investigate effect of LV remodeling on the presence of AF assessed by cardiovascular magnetic resonance (CMR) in HCM patients. METHODS: A total of 394 HCM patients were enrolled into this study, including HOCM patients (n = 293) and NOHCM patients (n = 101)...
November 3, 2018: BMC Cardiovascular Disorders
José González-Costello, Josep Comín-Colet, Josep Lupón, Cristina Enjuanes, Marta de Antonio, Lara Fuentes, Pedro Moliner-Borja, Nuria Farré, Elisabet Zamora, Nicolás Manito, Ramón Pujol, Antoni Bayés-Genis
BACKGROUND: Iron deficiency (ID) in patients with chronic heart failure (CHF) is considered an adverse prognostic factor. We aimed to evaluate if ID in patients with CHF is associated with increased mortality and hospitalizations. METHODS: We evaluated ID in patients with CHF at 3 university hospitals. ID was defined as absolute (ferritin < 100 μg/L) or functional (transferrin Saturation index < 20% and ferritin between 100 and 299 μg/L). We excluded patients who received treatment with intravenous Iron or Erythropoietin during follow-up...
November 1, 2018: BMC Cardiovascular Disorders
Oumin Shi, Anam M Khan, Mohammad R Rezai, Cynthia A Jackevicius, Jafna Cox, Clare L Atzema, Dennis T Ko, Thérèse A Stukel, Laurie J Lambert, Madhu K Natarajan, Zhi-Jie Zheng, Jack V Tu
BACKGROUND: Compared to ST-segment elevation myocardial infarction (STEMI) patients who present at centres with catheterization facilities, those transferred for primary percutaneous coronary intervention (PCI) have substantially longer door-in to door-out (DIDO) times, where DIDO is defined as the time interval from arrival at a non-PCI hospital, to transfer to a PCI hospital. We aimed to identify potentially modifiable factors to improve DIDO times in Ontario, Canada and to assess the impact of DIDO times on 30-day mortality...
October 29, 2018: BMC Cardiovascular Disorders
Tan Li, Bo Jiang, Xuan Li, Hai-Yang Sun, Xin-Tong Li, Jing-Jing Jing, Jun Yang
BACKGROUND: Matrix metalloproteinase-9 (MMP9) has been reported to play a key role in the pathogenesis of aortic aneurysm. However, few studies have assessed serum MMP9 levels in both abdominal aortic aneurysm (AAA) and thoracic aortic aneurysm (TAA). In this study, we investigated the serum levels of MMP9 in aortic aneurysm to evaluate its predictive and diagnostic efficacy for AAA and TAA, and explored the association of MMP9 with circulating laboratory markers. METHODS: A total of 296 subjects were enrolled, including 105 AAA patients, 79 TAA patients and 112 healthy controls...
October 29, 2018: BMC Cardiovascular Disorders
Lijun Hu, Chun Qiu, Xiaosong Wang, Mei Xu, Xiaoliang Shao, Yuetao Wang
BACKGROUND: In diabetes, dysregulated substrate utilization and energy metabolism of myocardium can lead to heart failure. To examine the dynamic changes of myocardium, most of the previous studies conducted dynamic myocardial PET imaging following euglycemic-hyperinsulinemic clamp, which involves complicated procedures. In comparison, the whole-body 18 F-FDG PET/CT scan is a simple and widely used method. Therefore, we hope to use this method to observe abnormal myocardial glucose metabolism in diabetes and determine the influencing factors...
October 29, 2018: BMC Cardiovascular Disorders
Francesco Santoro, Thomas Stiermaier, Francesca Guastafierro, Nicola Tarantino, Ingo Eitel, Natale Daniele Brunetti
Standard pharmacological therapy in Takotsubo syndrome (TTS) is still debated and there is a lack of prospective data. In their recent work in BMC Cardiovascular Disorders Abanador-Kamper et al. found that stroke in TTS has an event rate of 2.8% after 30 days and 4.2% after 12 months and they question which patients need oral anticoagulation. According to our clinical data, TTS patients with LV thrombi may be at high risk of stroke. These patients are characterized by apical ballooning pattern, high prevalence of ST-elevation and higher troponin I levels...
October 29, 2018: BMC Cardiovascular Disorders
Morten Malmborg, Christine Benn Christiansen, Michelle D Schmiegelow, Christian Torp-Pedersen, Gunnar Gislason, Morten Schou
BACKGROUND: Few studies have suggested that patients with myocardial infarction (MI) may be at increased risk of cancer, but further large register-based studies are needed to evaluate this subject. The aim of this study was to assess the incident rates of cancer and death by history of MI, and whether an MI is independently associated with cancer in a large cohort study. METHOD: All Danish residents aged 30-99 in 1996 without prior cancer or MI were included and were followed until 2012...
October 22, 2018: BMC Cardiovascular Disorders
Wonjae Lee, Jung-Won Suh, Jin Joo Park, Chang-Hwan Yoon, Young-Seok Cho, Tae-Jin Youn, In-Ho Chae
BACKGROUND: We conducted a randomized controlled trial to investigate whether an additional platelet inhibition with tirofiban would reduce the extent of myocardial damage and prevent periprocedural myonecrosis in patients with Non-ST-elevation acute coronary syndrome (NSTE-ACS) with a high residual platelet activity (HPR). METHODS: Patients with an HPR, defined as P2 Y12 reaction unit (PRU) > 230, were randomly assigned to group A (tirofiban treatment, n = 30) or C1 (n = 30) and patients without an HPR to C2 (n = 78)...
October 22, 2018: BMC Cardiovascular Disorders
Alina S Kerimkulova, Olga S Lunegova, Aibek E Mirrakhimov, Saamay S Abilova, Malik P Nabiev, Ksenia V Neronova, Erkaiym E Bektasheva, Ulan M Toktomamatov, Jyldyz E Esenbekova, Erkin M Mirrakhimov
BACKGROUND: It is known that atherosclerosis is the leading cause of cardiovascular disease. We aimed to study the correlation between components of metabolic syndrome (MS) and subclinical carotid atherosclerosis in a group of ethnic Kyrgyzs. METHODS: In а descriptive study we assessed 144 ethnic Kyrgyzs (69 males, 75 females) aged 36-73 years (average age 51.03 ± 8.2). All participants underwent a clinical investigation and an anthropometric evaluation (weight, height, waist circumference (WC))...
October 22, 2018: BMC Cardiovascular Disorders
Jung-Chi Hsu, Han-Lin Tsai, Yu-Ling Lin, Rei-Yeuh Chang
BACKGROUND: Radiofrequency ablation is a common and minimally invasive procedure used to treat liver tumors. However, the potential threat of heat injury to adjacent structures if the hepatic lesion is near the diaphragm is often overlooked and misunderstood. Rare cardiovascular complications have been reported. How best to identify the patients at risk to allow for prompt treatment is an important issue. CASE PRESENTATION: A 56-year-old man with underlying oral cancer received radiofrequency ablation for a metastatic liver tumor at segment II...
October 22, 2018: BMC Cardiovascular Disorders
Juho Heliste, Anne Jokilammi, Ilkka Paatero, Deepankar Chakroborty, Christoffer Stark, Timo Savunen, Maria Laaksonen, Klaus Elenius
BACKGROUND: Receptor tyrosine kinases (RTK) are potential targets for the treatment of ischemic heart disease. The human RTK family consists of 55 members, most of which have not yet been characterized for expression or activity in the ischemic heart. METHODS: RTK gene expression was analyzed from human heart samples representing healthy tissue, acute myocardial infarction or ischemic cardiomyopathy. As an experimental model, pig heart with ischemia-reperfusion injury, caused by cardiopulmonary bypass, was used, from which phosphorylation status of RTKs was assessed with a phospho-RTK array...
October 20, 2018: BMC Cardiovascular Disorders
Tarun Pant, Anuradha Dhanasekaran, Juan Fang, Xiaowen Bai, Zeljko J Bosnjak, Mingyu Liang, Zhi-Dong Ge
Long noncoding RNAs (lncRNAs) are endogenous RNA transcripts longer than 200 nucleotides which regulate epigenetically the expression of genes but do not have protein-coding potential. They are emerging as potential key regulators of diabetes mellitus and a variety of cardiovascular diseases. Diabetic cardiomyopathy (DCM) refers to diabetes mellitus-elicited structural and functional abnormalities of the myocardium, beyond that caused by ischemia or hypertension. The purpose of this review was to summarize current status of lncRNA research for DCM and discuss the challenges and possible strategies of lncRNA research for DCM...
October 20, 2018: BMC Cardiovascular Disorders
Yaobin Zhu, Jing Zhang, Zhiqiang Li, Yang Liu, Xing Fan, Yaping Zhang, Yanbo Zhang
BACKGROUND: The association of sodium intake with the risk of cardiovascular morbidity and mortality is inconsistent. Thus, the present meta-analysis was conducted to summarize the strength of association between sodium intake and cardiovascular morbidity and mortality. METHODS: PubMed, Embase, and the Cochrane Library were searched systematically to identify the relevant studies up to October 2017. The effect estimates for 100 mmol/day increase in sodium intake were calculated using 95% confidence intervals (CIs) of cardiac death, total mortality, stroke, or stroke mortality for low (< 3 g/d), moderate (3-5 g/d), or heavy (> 5 g/d) sodium intake, and minimal sodium intake comparison...
October 19, 2018: BMC Cardiovascular Disorders
Philippe Le Corvoisier, Romain Gallet, Pierre-François Lesault, Etienne Audureau, Muriel Paul, Julien Ternacle, Saïd Ghostine, Stéphane Champagne, Raphaele Arrouasse, Dalila Bitari, Gauthier Mouillet, Jean-Luc Dubois-Randé, Alain Berdeaux, Bijan Ghaleh, Jean-François Deux, Emmanuel Teiger
BACKGROUND: Experimental studies suggest that morphine may protect the myocardium against ischemia-reperfusion injury by activating salvage kinase pathways. The objective of this two-center, randomized, double-blind, controlled trial was to assess potential cardioprotective effects of intra-coronary morphine in patients with ST-segment elevation myocardial infarction (STEMI) referred for primary percutaneous intervention. METHODS: Ninety-one patients with STEMI were randomly assigned to intracoronary morphine (1 mg) or placebo at reperfusion of the culprit coronary artery...
October 19, 2018: BMC Cardiovascular Disorders
Rasaq Adisa, Olumide Ayodeji Ilesanmi, Titilayo Oyelola Fakeye
BACKGROUND: Treatment adherence play important roles in blood pressure control leading to reduction in morbidity and mortality. This study therefore assessed adherence to pharmacological and non-pharmacological therapies among ambulatory hypertensive patients. Reasons for treatment non-adherence, and association between adherence and blood pressure were also investigated. METHODS: Cross-sectional questionnaire-guided interview and retrospective review of medical records of 605-patients from two-tertiary healthcare institutions in Sokoto, Northwestern Nigeria...
October 19, 2018: BMC Cardiovascular Disorders
Nobuhiro Akuzawa, Masahiko Kurabayashi
BACKGROUND: Infective endocarditis due to Escherichia coli is a rare disease but is increasing in frequency, especially among older women. In addition, its mortality rate is higher than that of endocarditis due to the HACEK-group gram-negative bacteria (Haemophilus spp., Aggregatibacter spp., Cardiobacterium hominis, Eikenella corrodens, and Kingela spp.). CASE PRESENTATION: A 58-year-old Japanese woman with a history of alcohol abuse was admitted to our hospital because of a fever...
October 19, 2018: BMC Cardiovascular Disorders
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