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BMC Anesthesiology

H M Sohn, J S Baik, J Y Hwang, S Y Kim, S H Han, J H Kim
BACKGROUND: Microaspiration past the tracheal tube cuffs causes ventilator-associated pneumonia. The objective of the current study was to evaluate whether creating negative pressure between the tracheal double cuffs could block the fluid passage past the tracheal tube cuffs. METHODS: A new negative pressure system was devised between the double cuffs through a suction hole in the intercuff space. Blue-dyed water was instilled above the cuff at negative suction pressures of - 54, - 68, - 82, - 95, - 109, - 122, and - 136 cmH2 O, and the volume leaked was measured in an underlying water trap after 10 min...
December 3, 2018: BMC Anesthesiology
Romain Niessen, Benoit Bihin, Maximilien Gourdin, Jean-Cyr Yombi, Olivier Cornu, Patrice Forget
BACKGROUND: Elderly patients are at high risk for postoperative complications and increased mortality after hip fracture (HF) surgery due to frailty and co-morbidities. The prediction of postoperative outcome could be used for clinical decision making. A reliable score to predict postoperative mortality after HF surgery in this sub-population remains unavailable. METHODS: A single-centre retrospective cohort study was performed in 782 patients who were operated on for HF...
December 3, 2018: BMC Anesthesiology
Frank Schuster, Stephan Johannsen, Susanne Isbary, Ismail Türkmeneli, Norbert Roewer
BACKGROUND: The calcium sensitizer levosimendan is increasingly used to improve hemodynamics in patients with acutely decompensated heart failure. By binding to cardiac troponin C the conformation of the calcium-troponin C complex is stabilized, which leads to acceleration of actin-myosin crossbrigde formation and increased force generating capacity of muscle fibers. Besides indications in cardiac failure, beneficial effects of levosimendan in skeletal muscle disorders are currently evaluated...
December 3, 2018: BMC Anesthesiology
Joseph Makram Botros, Atef Mohamed Sayed Mahmoud, Safaa Gaber Ragab, Mohammed Awad Alsaeid Ahmed, Hany Maher Salib Roushdy, Hany Mahmoud Yassin, Maged Labib Bolus, Abeer Shaban Goda
BACKGROUND: Regional anesthesia could affect the homeostatic system functions resulting frequently in perioperative hypothermia and consequently shivering. The objective of this trial was to evaluate the efficacy of dexmedetomidine and ondansetron to reduce the incidence and severity of shivering after intrathecal blocks. METHODS: This randomized placebo-controlled trial included 120 patients allocated equally in three groups. All patients were anesthetized by standard intrathecal blocks for surgical procedure at lower half of the body and received one of the study drugs intravenously (IV) according to the group assignments...
November 30, 2018: BMC Anesthesiology
Amany H Saleh, Passaint F Hassan, Mohamed Elayashy, Hamza M Hamza, Mona H Abdelhamid, Mai A Madkour, Pierre Z Tawadros, Heba Omar, Mohamed M Kamel, Marwa Zayed, Mohamed Helmy
BACKGROUND: Surgery for aortic coarctation requires special care during anesthesia due to severe pain during the lateral thoracotomy incision, intraoperative hemodynamic instability and the need for large doses of intra- and postoperative analgesics and vasodilators. Additionally, the postoperative care of patients is very important. AIMS: We aimed to compare ultrasound-guided paravertebral block performed using bupivacaine alone and bupivacaine with dexamethasone in terms of the intra- and postoperative analgesic requirements and hemodynamics, postoperative complications and ICU stay...
November 30, 2018: BMC Anesthesiology
Mai Hokka, Moritoki Egi, Satoshi Mizobuchi
BACKGROUND: Current international guideline recommends to maintain blood glucose level ≤ 180 mg/dL in acute ill patients, irrespective of presence of premorbid diabetes. However, there are studies suggested that optimal acute glycemic control should be adjusted according to premorbid glycemic control in patients with chronic hyperglycemia. Accordingly, to obtain the information of premorbid glycemic control would be relevant. However, the HbA1c level on the day of the emergency operation (HbA1c-ope) might not be useful as a surrogate of premorbid chronic glycemic control, since glucose metabolism can be affected by inflammation, severity of illness and surgical invasion...
November 30, 2018: BMC Anesthesiology
Xu-Dong Yang, Li-Kuan Wang, Hai-Yin Wu, Liang Jiao
BACKGROUND: Surgery-induced neuroinflammation plays an important role in postoperative cognitive dysfunction (POCD). Gut microbiota is a key regulator of neurological inflammation. Nurturing with prebiotics is an effective microbiota manipulation that can regulate host immunity and cognition. The aim of the present study was to test whether administration of the prebiotic Bimuno® (galactooligosaccharide (B-GOS) mixture) could ameliorate POCD and attenuate surgery-induced neuroinflammation through the microbiota-brain-axis...
November 30, 2018: BMC Anesthesiology
John Song En Lee, Rehena Sultana, Nian Lin Reena Han, Alex Tiong Heng Sia, Ban Leong Sng
BACKGROUND: Epidural catheter re-siting in parturients receiving labour epidural analgesia is distressing to the parturient and places them at increased complications from a repeat procedure. The aim of this study was to develop and validate a clinical risk factor model to predict the incidence of epidural catheter re-siting in labour analgesia. METHODS: The data from parturients that received labour epidural analgesia in our centre during 2014-2015 was used to develop a predictive model for epidural catheter re-siting during labour analgesia...
November 29, 2018: BMC Anesthesiology
Hongfei Chen, Fangfang Xia, Zhousheng Jin, Kejian Shi, Yun Xia, Le Liu, Thomas J Papadimos, Xuzhong Xu, Limei Chen
BACKGROUND: Successful resuscitation from asystole induced by bupivacaine requires the reestablishment of a sufficient coronary flow (CF) quickly. This study was designed to test whether levosimendan was superior to epinephrine in the reestablishment of crucial coronary flows after bupivacaine-induced asystole. METHODS: The isolated, perfused, nonrecirculating, Langendorff rat heart preparation was used. Bupivacaine 100 μmol/L was perfused into rat hearts to induce asystole, and then for 3 min thereafter...
November 20, 2018: BMC Anesthesiology
Sibel Oba, Hacer Şebnem Türk
BACKGROUND: The side and adverse effects of anesthesia and its neurotoxicity to children have become major concerns of anesthesiologists in recent years. Currently, no clinical trials have provided clear evidence indicating the suitable minimum age for a patient's first anesthetic application, importance of anesthesia duration, number of anesthetic applications or interval between two consecutive anesthesia applications. A very rare case concerning the side, adverse and neurotoxic effects of multiple anesthesia in a child is presented...
November 20, 2018: BMC Anesthesiology
Kai-Kai Guo, Cheng-Qi Deng, Gui-Jun Lu, Guo-Li Zhao
After publication of this article [1], the authors noted that the corresponding email address is incorrect.
November 19, 2018: BMC Anesthesiology
Shiquan Wang, Yuheng Li, Jinlong Wei, Pei Li, Qianzi Yang
BACKGROUND: Sevoflurane preconditioning induces brain ischemic tolerance, but the mechanism remains poorly elucidated. Nitration is an important form of post-translational modification in pathological signaling. This study was to investigate the role of thioredoxin-1 (Trx-1) nitration in neuroprotection effect induced by sevoflurane preconditioning in a transient stroke model in rats. METHODS: Adult male Sprague-Dawley rats were preconditioned with 2% sevoflurane or vehicle oxygen exposure, 1 h per day, for 5 consecutive days...
November 17, 2018: BMC Anesthesiology
Lanqi Guo, Jianfeng Xie, Yingzi Huang, Chun Pan, Yi Yang, Haibo Qiu, Ling Liu
BACKGROUND: Mortality in patients with acute respiratory distress syndrome (ARDS) remains high. These patients require mechanical ventilation strategies that include high positive end-expiratory pressure (PEEP). It remains controversial whether high PEEP can improve outcomes for ARDS patients, especially patients who show improvement in oxygenation in response to PEEP. In this meta-analysis, we aimed to evaluate the effects of high PEEP on ARDS patients. METHODS: We electronically searched randomized controlled trials (RCTs) reported in the MEDLINE, CENTRAL, EMBASE, CINAHL and Web of Science databases from January 1990 to December 2017...
November 17, 2018: BMC Anesthesiology
Weifang Yuan, Wei Zhang, Xiaofang Yang, Liyuan Zhou, Ziwei Hanghua, Kailiang Xu
BACKGROUND: Tenascin-C is a pro-inflammatory glycoprotein with various biological functions. High expression of tenascin-C is found in inflammation, tissue remodeling, and autoimmune diseases. However, its expression and clinical significance in sepsis remain unclear. This study was designed to investigate the relationship between serum tenascin-C levels and disease severity and prognosis in patients with sepsis. METHODS: A total of 167 patients with sepsis admitted to the ICU were enrolled...
November 15, 2018: BMC Anesthesiology
Ling-Yu Xing, Jun Yin, Mian Shao, Yi-Lin Yang, Ke-Yong Li, Ming-Ming Xue, Su-Cheng Mu, Zhan Sun, Ya-Ping Zhang, Chen-Ling Yao, Xun Chu, Chao-Yang Tong, Zhen-Ju Song
BACKGROUND: Cavity effusion is common in patients with infectious diseases. However, the incidence rate and characteristics of serous cavity effusions (SCE) in septic patients are not clear to date. The objective of this study was to investigate the incidence and characteristics of SCE in septic patients and to explore the correlations between the bloody effusions and the illness severity/prognosis in septic patients. METHODS: From January 2010 to January 2015, a total of 214 patients with severe sepsis and septic shock were enrolled in this retrospective observational study...
November 14, 2018: BMC Anesthesiology
Bo Yao, Jian-Yu Liu, Yun-Bo Sun
BACKGROUND: Fluid overloading is detrimental to organ function and results in a poor prognosis. It is necessary to evaluate fluid responsiveness before fluid loading. We performed a systematic meta-analysis to evaluate the diagnostic value of the respiratory variation in peripheral arterial blood flow peak velocity (△Vpeak PA) in predicting fluid responsiveness in mechanically ventilated patients. METHODS: PubMed, Embase and The Cochrane Library databases were searched for studies that used △Vpeak PA to predict fluid responsiveness in mechanically ventilated patients...
November 13, 2018: BMC Anesthesiology
Jozica Wagner-Kovacec, Petra Povalej-Brzan, Dusan Mekis
BACKGROUND: In-wound catheters for infusion of local anaesthetic for post-caesarean section analgesia are well tolerated in parturients. Few studies have examined continuous in-wound infusion of a combination of local anaesthetic and non-steroidal anti-inflammatory drug for post-caesarean section analgesia. This single centre study evaluated post-operative analgesic efficacy and piritramide-sparing effects of continuous in-wound infusion of either local anaesthetic or non-steroidal anti-inflammatory agent, or the combination of both, versus saline placebo, when added to systemic analgesia with paracetamol...
November 10, 2018: BMC Anesthesiology
Andrea Cortegiani, Giuseppe Accurso, Sebastiano Mercadante, Antonino Giarratano, Cesare Gregoretti
BACKGROUND: High flow nasal therapy (HFNT) is a technique in which humidified and heated gas is delivered to the airways through the nose via small nasal prongs at flows that are higher than the rates generally applied during conventional oxygen therapy. The delivered high flow rates combine mixtures of air and oxygen and enable different inspired oxygen fractions ranging from 0.21 to 1. HFNT is increasingly used in critically ill adult patients, especially hypoxemic patients in different clinical settings...
November 10, 2018: BMC Anesthesiology
Sho Kawasaki, Chikako Kiyohara, Shoji Tokunaga, Sumio Hoka
BACKGROUND: Although propofol is a common anesthetic agent for the induction of general anesthesia, hemodynamic fluctuations are occasionally prominent during induction/intubation. The aims of this study were to determine the influential factors on enhanced hemodynamic fluctuation and to establish a prediction formula to quickly determine the dose of propofol to protect against hemodynamic fluctuations. METHODS: This retrospective cohort study patients (n = 2097) were 18 years or older...
November 10, 2018: BMC Anesthesiology
Stefan Schraag, Lorenzo Pradelli, Abdul Jabbar Omar Alsaleh, Marco Bellone, Gianni Ghetti, Tje Lin Chung, Martin Westphal, Sebastian Rehberg
BACKGROUND: It is unclear if anaesthesia maintenance with propofol is advantageous or beneficial over inhalational agents. This study is intended to compare the effects of propofol vs. inhalational agents in maintaining general anaesthesia on patient-relevant outcomes and patient satisfaction. METHODS: Studies were identified by electronic database searches in PubMed™, EMBASE™ and the Cochrane™ library between 01/01/1985 and 01/08/2016. Randomized controlled trials (RCTs) of peer-reviewed journals were studied...
November 8, 2018: BMC Anesthesiology
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