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BMC Pediatrics

Malindi van der Mheen, Ingrid M van Beynum, Karolijn Dulfer, Jan van der Ende, Eugène van Galen, Jorieke Duvekot, Lisette E Rots, Tabitha P L van den Adel, Ad J J C Bogers, Christopher G McCusker, Frank A Casey, Willem A Helbing, Elisabeth M W J Utens
BACKGROUND: Children with congenital heart disease (CHD) are at increased risk for behavioral, emotional, and cognitive problems. They often have reduced exercise capacity and participate less in sports, which is associated with a lower quality of life. Starting school may present more challenges for children with CHD and their families than for families with healthy children. Moreover, parents of children with CHD are at risk for psychosocial problems. Therefore, a family-centered psychosocial intervention for children with CHD when starting school is needed...
July 12, 2018: BMC Pediatrics
Lisa B E Shields, Dennis S Peppas, Eran Rosenberg
BACKGROUND: Lesch-Nyhan syndrome is a rare inborn error of purine metabolism marked by a complete deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT). Inherited as an X-linked recessive genetic disorder that primarily affects males, patients with Lesch-Nyhan syndrome exhibit severe neurological impairments, including choreoathetosis, ballismus, cognitive dysfunction, and self-injurious behavior. Uric acid levels are usually abnormally high, leading to kidney and bladder stones which often necessitate urological intervention...
July 12, 2018: BMC Pediatrics
Xin-Qiong Wang, Yuan Xiao, Xu Xu, Yi Yu, Cheng-Yan Shan, Yan Guo, Ling Gong, Tong Zhou, Shen-Shen Gao, Yao-Zong Yuan, Xiao-Jin Wang, Chun-Di Xu
BACKGROUND: To investigate the unique features of inflammatory bowel disease (IBD) in children, we wanted to identify whether there might be a strong correlation between the disease phenotype and its prognosis at various ages in paediatric patients. METHODS: We collected data from patients diagnosed with IBD (ulcerative colitis (UC) or Crohn's disease (CD)) from 2002 to 2016. The diagnosis was made according to the Porto criteria and Paris Classification. Patient characteristics, clinical manifestations and treatments were collected...
July 12, 2018: BMC Pediatrics
Wenlong Gao, Guirong Li, Xiaoning Liu, Hong Yan
BACKGROUND: It was unclear how and to what extent the "Child Care" intervention (CCI) in rural Primary Health Care Program affected the prevalence of childhood diarrhea in rural western China. METHODS: The available data of 10,829 and 10,682 households was collected from shared 34 counties of 9 provinces of western China in 2001 and 2005 respectively. A log-binomial regression model was used to predict the effect of CCI on prevalence of childhood diarrhea...
July 11, 2018: BMC Pediatrics
Vidit Bhargava, Daniel Tawfik, Bruce Niebuhr, Sunil K Jain
BACKGROUND: Measurement of transcutaneous bilirubin (TcB) is a quick, reliable and painless method to guide management of hyperbilirubinemia. Studies in term and late preterm infants have found that TcB measurements from covered areas (TcB-C) during phototherapy (PHT) co-relate well with serum bilirubin levels. Limited data exists in extremely low birth weight (ELBW) infants. METHODS: In this prospective observational study, an opaque patch was placed on the back of an ELBW infant prior to initiation of PHT...
July 10, 2018: BMC Pediatrics
Hans Ulrich Bucher, Sabine D Klein, Manya J Hendriks, Ruth Baumann-Hölzle, Thomas M Berger, Jürg C Streuli, Jean-Claude Fauchère
After publication of the original article [1], the corresponding author noticed the given names and family names of the members included in the Swiss Neonatal End-of-Life Study Group were incorrectly reverted.
July 9, 2018: BMC Pediatrics
R Chingono, H Mebrahtu, Z Mupambireyi, V Simms, H A Weiss, P Ndlovu, F Charasika, M Tomlinson, L D Cluver, F M Cowan, L Sherr
BACKGROUND: HIV infection in a family may affect optimum child development. Our hypothesis is that child development outcomes among HIV-exposed infants will be improved through a complex early childhood stimulation (ECS) programme, and income and loans saving programme for HIV positive parents. METHODS: The study was a cluster-randomized controlled trial in 30 clinic sites in two districts in Zimbabwe. Clinics were randomised in a 1:1 allocation ratio to the Child Health Intervention for Development Outcomes (CHIDO) intervention or Ministry of Health standard care...
July 9, 2018: BMC Pediatrics
Shuby Puthussery, Muhammad Chutiyami, Pei-Ching Tseng, Lesley Kilby, Jogesh Kapadia
BACKGROUND: Various intervention programs exist for parents of preterm babies and some systematic reviews (SRs) have synthesised the evidence of their effectiveness. These reviews are, however, limited to specific interventions, components, or outcomes, and a comprehensive evidence base is lacking. The aim of this meta-review was to appraise and meta-synthesise the evidence from existing SRs to provide a comprehensive evidence base on the effectiveness of interventions for parents of preterm infants on parental and infant outcomes...
July 9, 2018: BMC Pediatrics
Audrey Vincent, Jean-Claude Souberbielle, Raja Brauner
BACKGROUND: The bone markers bone alkaline phosphatase (BAP) and C-terminal telopeptide of type I collagen crosslinks (CTX) are correlated with growth rate during normal puberty. The objective of this study was to evaluate the relationship between the serum concentrations of BAP and CTX and growth evolution in girls with idiopathic central precocious puberty (CPP) to help predict adult height. METHODS: A retrospective single-center study was conducted in 74 girls with CPP for whom a serum sample at initial evaluation was available to retrospectively measure BAP and CTX concentrations; 66...
July 9, 2018: BMC Pediatrics
Ingrid A Holm, Pankaj B Agrawal, Ozge Ceyhan-Birsoy, Kurt D Christensen, Shawn Fayer, Leslie A Frankel, Casie A Genetti, Joel B Krier, Rebecca C LaMay, Harvey L Levy, Amy L McGuire, Richard B Parad, Peter J Park, Stacey Pereira, Heidi L Rehm, Talia S Schwartz, Susan E Waisbren, Timothy W Yu, Robert C Green, Alan H Beggs
BACKGROUND: The greatest opportunity for lifelong impact of genomic sequencing is during the newborn period. The "BabySeq Project" is a randomized trial that explores the medical, behavioral, and economic impacts of integrating genomic sequencing into the care of healthy and sick newborns. METHODS: Families of newborns are enrolled from Boston Children's Hospital and Brigham and Women's Hospital nurseries, and half are randomized to receive genomic sequencing and a report that includes monogenic disease variants, recessive carrier variants for childhood onset or actionable disorders, and pharmacogenomic variants...
July 9, 2018: BMC Pediatrics
Darren Reithmeier, Richard Tang-Wai, Blair Seifert, Andrew W Lyon, Jane Alcorn, Bryan Acton, Scott Corley, Erin Prosser-Loose, Darrell D Mousseau, Hyun J Lim, Jose Tellez-Zenteno, Linda Huh, Edward Leung, Lionel Carmant, Richard J Huntsman
BACKGROUND: Initial studies suggest pharmaceutical grade cannabidiol (CBD) can reduce the frequency of convulsive seizures and lead to improvements in quality of life in children affected by epileptic encephalopathies. With limited access to pharmaceutical CBD, Cannabis extracts in oil are becoming increasingly available. Physicians show reluctance to recommend Cannabis extracts given the lack of high quality safety data especially regarding the potential for harm caused by other cannabinoids, such as Δ9 -tetrahydrocannabinol (Δ9 -THC)...
July 7, 2018: BMC Pediatrics
Frank H Bloomfield, Jane E Harding, Michael P Meyer, Jane M Alsweiler, Yannan Jiang, Clare R Wall, Tanith Alexander
BACKGROUND: Babies born at moderate-late preterm gestations account for > 80% of all preterm births. Although survival is excellent, these babies are at increased risk of adverse neurodevelopmental outcomes. They also are at increased risk of adverse long-term health outcomes, such as cardiovascular disease, obesity and diabetes. There is little evidence guiding optimal nutritional practices in these babies; practice, therefore, varies widely. This factorial design clinical trial will address the role of parenteral nutrition, milk supplementation and exposure of the preterm infant to taste and smell with each feed on time to tolerance of full feeds, adiposity, and neurodevelopment at 2 years...
July 7, 2018: BMC Pediatrics
Xiao-Lan Ying, Morri Markowitz, Chong-Huai Yan
BACKGROUND: Folk prescriptions continue to be important sources of childhood lead poisoning. Nasal spray folk prescriptions for treating rhinitis has only been reported once previously as a cause of lead poisoning. CASE PRESENTATION: We identified three pediatric cases of severe lead poisoning caused by nasal spray folk medicines prescribed for treating rhinitis. The three patients had similar clinical manifestations including: severe abdominal pain, headache, pale appearance and fatigue...
July 6, 2018: BMC Pediatrics
Libby Haskell, Emma J Tavender, Catherine Wilson, Sharon O'Brien, Franz E Babl, Meredith L Borland, Liz Cotterell, Tibor Schuster, Francesca Orsini, Nicolette Sheridan, David Johnson, Ed Oakley, Stuart R Dalziel
BACKGROUND: Bronchiolitis is the most common reason for admission to hospital for infants less than one year of age. Although management is well defined, there is substantial variation in practice, with infants receiving ineffective therapies or management. This study will test the effectiveness of tailored, theory informed knowledge translation (KT) interventions to decrease the use of five clinical therapies or management processes known to be of no benefit, compared to usual dissemination practices in infants with bronchiolitis...
July 6, 2018: BMC Pediatrics
Anh Thi Nguyet Nguyen, Muneko Nishijo, Tai The Pham, Nghi Ngoc Tran, Anh Hai Tran, Luong Van Hoang, Hitomi Boda, Yuko Morikawa, Yoshikazu Nishino, Hisao Nishijo
BACKGROUND: We previously reported that perinatal dioxin exposure increased autistic traits in children living in dioxin-contaminated areas of Vietnam. In the present study, we investigated the impact of dioxin exposure on children's eating behavior, which is often altered in those with developmental disorders. METHODS: A total of 185 mother-and-child pairs previously enrolled in a birth cohort in dioxin-contaminated areas participated in this survey, conducted when the children reached 3 years of age...
July 5, 2018: BMC Pediatrics
Yunkoo Kang, Sowon Park, Seung Kim, Hong Koh
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is complicated disease and increasing worldwide. Previously, many studies of NALFD prevalences have used alanine aminotransferase (ALT) of > 40 U/L to define NAFLD, although that is too high to be reliable among adolescents. This study aimed to define the upper normal limit of ALT among Korean adolescents, and use it to estimate the prevalence of NAFLD, based on data from the Korea National Health and Nutrition Examination Survey (KNHANES)...
July 5, 2018: BMC Pediatrics
Iole Brunod, Barthélémy Tosello, Sophie Hassid, Catherine Gire, Laurent Thomachot, Michel Panuel
BACKGROUND: Generalized Arterial Calcification of Infancy (GACI) is a heritable ectopic mineralization disorder resulting in diffuse arterial calcifications and/or stenosis, mostly caused by mutations in the ENPP1 gene. Here we present a case report of GACI in a male infant with a new familial mutation of the ENPP1 gene and the clinical outcome after biphosphonates therapy. CASE PRESENTATION: The clinical presentation was characterized by a severe early-onset of hypertension refractory to multiple therapy...
July 5, 2018: BMC Pediatrics
Jiayi Chen, Pengwei Hu, Tao Zhou, Tianli Zheng, Lingxu Zhou, Chunping Jiang, Xiaofang Pei
BACKGROUND: Acute respiratory infection (ARI) is the leading cause of morbidity and mortality in pediatric patients worldwide and imposes an intense pressure on health care facilities. Data on the epidemiology profiles of ARIs are scarce in the western and rural areas of China. The purpose of the current study is to provide data on the presence of potential pathogens of ARIs in hospitalized children in Chengdu, west China. METHODS: Respiratory specimens were obtained from hospitalized patients (under 6 years old) with ARIs in a local hospital in Chengdu...
July 5, 2018: BMC Pediatrics
Giangiacomo Nicolini, Martina Borellini, Vitaliana Loizzo, Roberta Creti, Luigi Memo, Alberto Berardi
BACKGROUND: Human milk is fundamental for its nutritional properties and to protect newborns, but it is not sterile and can sometime transmit bacteria. Few anecdotal cases suggest that breast milk could be a possible source of group B Streptococcus (GBS) late onset disease, although the pathogenesis is not entirely understood. CASE PRESENTATION: We report 3 cases of GBS late onset disease in full-term newborns. Fresh breast milk cultures yielded GBS, but mothers of neonates had no signs of mastitis and remained persistently GBS negative at rectovaginal site...
July 5, 2018: BMC Pediatrics
João Valente-Dos-Santos, Óscar M Tavares, João P Duarte, Paulo M Sousa-E-Silva, Luís M Rama, José M Casanova, Carlos A Fontes-Ribeiro, Elisa A Marques, Daniel Courteix, Enio R V Ronque, Edilson S Cyrino, Jorge Conde, Manuel J Coelho-E-Silva
BACKGROUND: Exploring the osteogenic effect of different bone-loading sports is particular relevant to understand the interaction between skeletal muscle and bone health during growth. This study aimed to compare total and regional bone and soft-tissue composition between female adolescent swimmers (n=20, 15.71±0.93 years) and volleyball players (n=26, 16.20±0.77 years). METHODS: Dietary intake was obtained using food frequency questionnaires. Body size was given by stature, sitting height, and body mass...
July 3, 2018: BMC Pediatrics
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