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BMC Pediatrics

Andrea Pietravalle, Francesco Cavallin, Anna Opocher, Stefania Madella, Maria Elena Cavicchiolo, Damiano Pizzol, Giovanni Putoto, Daniele Trevisanuto
BACKGROUND: Stimulation is the most common intervention during neonatal resuscitation at birth, but scarce information is available on the actual methods, timing and efficacy of this basic step. To evaluate the occurrence, patterns and response to tactile stimulation at birth in a low-resource setting. METHODS: We reviewed 150 video recordings of neonatal resuscitation at Beira Central Hospital (Beira, Mozambique). Timing, method, duration and response to tactile stimulation were evaluated...
September 20, 2018: BMC Pediatrics
Wen-Yuan Liu, Zhe-Bin Yu, Hai-Yan Qiu, Jian-Bing Wang, Xue-Yu Chen, Kun Chen
BACKGROUND: Exposure to air pollutants has been related to preterm birth, but little evidence can be available for PM2.5 , O3 and CO in China. This study aimed to investigate the short-term effect of exposure to air pollutants on risk preterm birth during 2014-2016 in Ningbo, China. METHODS: We conducted a time-series study to evaluate the associations between daily preterm birth and major air pollutants (including PM2.5 , PM10 , SO2 , NO2 , O3 and CO) in Ningbo during 2014-2016...
September 20, 2018: BMC Pediatrics
Ayana Chimdessa, Amsale Cheire
BACKGROUND: The life and health of street children is becoming a global concern. Street children are vulnerable to a variety of problems including physical, psychological and sexual exploitations as well as social isolation. Therefore, it was the purpose of this study to point out the experience of sexual and physical exploitation and its determinant factors among street children in Addis Ababa, the capital city of Ethiopia. METHODOLOGY: A phenomenological qualitative method was conducted from March to June 2016 in Addis Ababa, Ethiopia...
September 19, 2018: BMC Pediatrics
Samah Riaz, Andrew Rowland, Steve Woby, Tony Long, Joan Livesley, Sarah Cotterill, Calvin Heal, Damian Roland
BACKGROUND: Increasing attendances by children (aged 0-16 years) to United Kingdom Emergency Departments (EDs) challenges patient safety within the National Health Service (NHS) with health professionals required to make complex judgements on whether children attending urgent and emergency care services can be sent home safely or require admission. Health regulation bodies have recommended that an early identification systems should be developed to recognise children developing critical illnesses...
September 17, 2018: BMC Pediatrics
Hajnalka Barta, Agnes Jermendy, Marton Kolossvary, Lajos R Kozak, Andrea Lakatos, Unoke Meder, Miklos Szabo, Gabor Rudas
BACKGROUND: Neonatal hypoxic-ischemic encephalopathy (HIE) commonly leads to neurodevelopmental impairment, raising the need for prognostic tools which may guide future therapies in time. Prognostic value of proton MR spectroscopy (H-MRS) between 1 and 46 days of age has been extensively studied; however, the reproducibility and generalizability of these methods are controversial in a general clinical setting. Therefore, we investigated the prognostic performance of conventional H-MRS during first 96 postnatal hours in hypothermia-treated asphyxiated neonates...
September 15, 2018: BMC Pediatrics
Agnieszka Guzik, Mariusz Drużbicki, Andrzej Kwolek, Grzegorz Przysada, Katarzyna Bazarnik-Mucha, Magdalena Szczepanik, Andżelina Wolan-Nieroda, Marek Sobolewski
BACKGROUND: In clinical practice there is a need for a specific scale enabling detailed and multifactorial assessment of gait in children with spastic hemiplegic cerebral palsy. The practical value of the present study is linked with the attempts to find a new, affordable, easy-to-use tool for gait assessment in children with spastic hemiplegic cerebral palsy. The objective of the study is to evaluate the Wisconsin Gait Scale (WGS) in terms of its inter- and intra-rater reliability in observational assessment of walking in children with hemiplegic cerebral palsy...
September 15, 2018: BMC Pediatrics
Jed Dimaisip-Nabuab, Denise Duijster, Habib Benzian, Roswitha Heinrich-Weltzien, Amphayvan Homsavath, Bella Monse, Hak Sithan, Nicole Stauf, Sri Susilawati, Katrin Kromeyer-Hauschild
BACKGROUND: Untreated dental caries is reported to affect children's nutritional status and growth, yet evidence on this relationship is conflicting. The aim of this study was to assess the association between dental caries in both the primary and permanent dentition and nutritional status (including underweight, normal weight, overweight and stunting) in children from Cambodia, Indonesia and Lao PDR over a period of 2 years. A second objective was to assess whether nutritional status affects the eruption of permanent teeth...
September 14, 2018: BMC Pediatrics
Kathy M Manhire, Sheila M Williams, David Tipene-Leach, Sally A Baddock, Sally Abel, Angeline Tangiora, Raymond Jones, Barry J Taylor
BACKGROUND: Although breastfeeding duration in New Zealand's indigenous Māori is shorter than in non-Māori, we know little about barriers or motivators of breastfeeding in this community. The aim of this analysis was to identify predictors for extended duration of breastfeeding amongst participants drawn from predominantly Māori communities in regional Hawke's Bay. METHODS: Mother/baby dyads were recruited from two midwifery practices serving predominantly Māori women in mostly deprived areas, for a randomised controlled trial comparing the risks and benefits of an indigenous sleeping device (wahakura) and a bassinet...
September 12, 2018: BMC Pediatrics
Sung-Jin Baek, Jung Hye Byeon, So-Hee Eun, Baik-Lin Eun, Gun-Ha Kim
BACKGROUND: Suboptimal intake of magnesium become prevalent due to the modern diet of processed food low in magnesium. Magnesium may modulate seizure activity by antagonizing excitatory calcium influx through the N-methyl-D-aspartate receptor. Although hyponatremia has been reported to be common in febrile seizures, the most common form of seizure, little is known about the status of serum ionized magnesium. We therefore investigated the status of serum ionized magnesium (iMg2+ ) in children with febrile seizures and compared with controls...
September 7, 2018: BMC Pediatrics
Irene Plaza Pinto, Lysa Bernardes Minasi, Raphael Steckelberg, Claudio Carlos da Silva, Aparecido Divino da Cruz
BACKGROUND: Supernumerary Marker Chromosomes consist in structurally abnormal chromosomes, considered as an extra chromosome in which around 70% occur as a de novo event and about 30% of the cases are mosaic. Tetrasomy 9p is a rare chromosomal abnormality described as the presence of a supernumerary isochromosome 9p. Clinical features of tetrasomy 9p include a variety of physical and developmental abnormalities. CASE PRESENTATION: Herein, we reported a postnatal case of a newborn who died in early infancy with multiple congenital malformations due to a mosaic de novo tetrasomy 9p detected by Chromosomal Microarray Analysis...
September 7, 2018: BMC Pediatrics
Hye Ah Lee, Bo Hyun Park, Eun Ae Park, Su Jin Cho, Hae Soon Kim, Hyesook Park
BACKGROUND: We evaluated the effects of two single-nucleotide polymorphisms on UA concentrations in the first decade of life using repeated-measures data. METHODS: We included all subjects who were followed-up at least once and for whom we had both UA and genotypic data (i.e., 375, 204, 307, and 363 patients aged 3, 5, 7, and 9 years, respectively). All participated in the Ewha Birth and Growth Cohort study. We used a mixed model analysis to estimate the longitudinal association of serum UA concentration due to the rs3825017 (SLC22A12 c...
September 6, 2018: BMC Pediatrics
Giuseppina Sgandurra, Elena Beani, Matteo Giampietri, Riccardo Rizzi, Giovanni Cioni
BACKGROUND: Congenital brain lesions expose infants to be at high-risk for being affected by neurodevelopmental disorders such as cerebral palsy (CP). Early interventions programs can significantly impact and improve their neurodevelopment. Recently, in the framework of the European CareToy (CT) Project ( ), a new medical device has been created to deliver an early, intensive, customized, intervention program, carried out at home by parents but remotely managed by expert and trained clinicians...
September 5, 2018: BMC Pediatrics
N Milne, K Cacciotti, K Davies, R Orr
BACKGROUND: Movement and physical activity is crucial to brain development and has a positive impact on the ability to learn. With children spending a large portion of their time in the school setting, physical activity and the development of motor skills in this environment may not only impact their overall development but may also influence their learning. The aim of this study was to investigate relationships between motor proficiency and reading skills in Year-1 children. METHODS: A cross-sectional study with a single class of Year-1 students (n = 24: mean age = 6...
September 5, 2018: BMC Pediatrics
Jennifer S Savage, Samantha M R Kling, Adam Cook, Lindsey Hess, Shawnee Lutcher, Michele Marini, Jacob Mowery, Shannon Hayward, Sandra Hassink, Jennifer Franceschelli Hosterman, Ian M Paul, Chris Seiler, Lisa Bailey-Davis
BACKGROUND: Economically disadvantaged families receive care in both clinical and community settings, but this care is rarely coordinated and can result in conflicting educational messaging. WEE Baby Care is a pragmatic randomized clinical trial evaluating a patient-centered responsive parenting (RP) intervention that uses health information technology (HIT) strategies to coordinate care between pediatric primary care providers (PCPs) and the Special Supplemental Nutrition Program for Women, Infant and Children (WIC) community nutritionists to prevent rapid weight gain from birth to 6 months...
September 4, 2018: BMC Pediatrics
Gunadi, Nova Yuli Prasetyo Budi, Raman Sethi, Aditya Rifqi Fauzi, Alvin Santoso Kalim, Taufik Indrawan, Kristy Iskandar, Akhmad Makhmudi, Indra Adrianto, Lai Poh San
BACKGROUND: Hirschsprung disease (HSCR) is a heterogeneous genetic disorder characterized by absence of ganglion cells along the intestines resulting in functional bowel obstruction. Mutations in neuregulin 1 (NRG1) gene have been implicated in some cases of intestinal aganglionosis. This study aims to investigate the contribution of the NRG1 gene to HSCR development in an Indonesian population. METHODS: We analyzed the entire coding region of the NRG1 gene in 54 histopathologically diagnosed HSCR patients...
September 4, 2018: BMC Pediatrics
Brennan Vail, Melissa C Morgan, Hilary Spindler, Amelia Christmas, Susanna R Cohen, Dilys M Walker
BACKGROUND: Globally, neonatal mortality accounts for nearly half of under-five mortality, and intrapartum related events are a leading cause. Despite the rise in neonatal resuscitation (NR) training programs in low- and middle-income countries, their impact on the quality of NR skills amongst providers with limited formal medical education, particularly those working in rural primary health centers (PHCs), remains incompletely understood. METHODS: This study evaluates the impact of PRONTO International simulation training on the quality of NR skills in simulated resuscitations and live deliveries in rural PHCs throughout Bihar, India...
September 3, 2018: BMC Pediatrics
Shigeo Iijima, Daizo Ueno, Toru Baba, Akira Ohishi
BACKGROUND: Although persistent pulmonary hypertension of the newborn (PPHN) and infantile hypertrophic pyloric stenosis (HPS) are both well-known diseases that occur in early infancy, PPHN complicated by HPS is rare. As nitric oxide (NO) is an important mediator of biological functions, on both the vascular endothelium and smooth muscle cells, the decreased production of NO might play a role in the pathogenesis of both PPHN and HPS. We present the case of a neonate who developed HPS following PPHN, including a detailed review on research published to date, and we discuss the pathogenesis of PPHN and HPS...
September 3, 2018: BMC Pediatrics
S Haithar, M W Kuria, A Sheikh, M Kumar, A Vander Stoep
BACKGROUND: Depression is the leading cause of disease-related disability in women and adversely affects the health and well-being of mothers and their children. Studies have shown maternal depression as a risk factor for poor infant growth. Little is known about the situation in Sub-Saharan Africa. The aim of our study was to examine the association between maternal depression and severe acute malnutrition in Kenyan children aged 6-60 months. METHODS: A matched case-control study was conducted in general paediatric wards at the Kenyatta National Hospital...
September 3, 2018: BMC Pediatrics
Vianney Gilard, Alexandra Chadie, François-Xavier Ferracci, Marie Brasseur-Daudruy, François Proust, Stéphane Marret, Sophie Curey
BACKGROUND: Intraventricular hemorrhage (IVH) is a frequent complication in extreme and very preterm births. Despite a high risk of death and impaired neurodevelopment, the precise prognosis of infants with IVH remains unclear. The objective of this study was to evaluate the rate and predictive factors of evolution to post hemorrhagic hydrocephalus (PHH) requiring a shunt, in newborns with IVH and to report their neurodevelopmental outcomes at 2 years of age. METHODS: Among all preterm newborns admitted to the department of neonatalogy at Rouen University Hospital, France between January 2000 and December 2013, 122 had an IVH and were included in the study...
August 31, 2018: BMC Pediatrics
Xike Wang, Haitao Wei, Ying Tian, Yue Wu, Lei Luo
BACKGROUND: Conotruncal heart defects (CTDs) are a subgroup of congenital heart defects that are considered to be the most common type of birth defect worldwide. Genetic disturbances in folate metabolism may increase the risk of CTDs. METHODS: We evaluated five single-nucleotide polymorphisms (SNPs) in genes related to folic acid metabolism: methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), solute carrier family 19, member 1 (SLC19A1 G80A), methionine synthase (MTR A2576G), and methionine synthase reductase (MTRR A66G), as risk factors for CTDs including various types of malformation, in a total of 193 mothers with CTD-affected offspring and 234 healthy controls in a Chinese population...
August 30, 2018: BMC Pediatrics
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