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BMC Ophthalmology

Mathieu Gauvin, Avi Wallerstein
BACKGROUND: Standardization for reporting medical outcomes facilitates clinical study comparisons and has a fundamental role on research reproducibility. In this context, we present AstigMATIC, a free standalone application for automated standardized astigmatism vector analyses in corneal and intraocular refractive surgeries. AstigMATIC uses a simple graphical user interface (GUI) and allows the simultaneous display and analysis of astigmatism magnitude and axis. RESULTS: The software produces the four following standard graphs according to the standards of the Alpins Method; 1-Target-Induced Astigmatism Vector, 2- Surgically-Induced Astigmatism Vector, 3-Difference Vector and 4-Correction Index...
September 21, 2018: BMC Ophthalmology
Hatem M Marey, Hesham M Elmazar, Sameh S Mandour, Osama A El Morsy
BACKGROUND: To introduce and evaluate the application of Ologen implants in external Dacryocystorhinostomy (DCR) Surgeries. METHODS: Prospective comparative randomized study was carried out on 60 patients coming to ophthalmology department, Menoufia University Hospitals. Patients included were suffering from primary acquired nasolacrimal duct obstruction with positive regurge test. Patients were randomly enrolled into two groups using alternating choice technique...
September 20, 2018: BMC Ophthalmology
Haeng-Jin Lee, Seong-Joon Kim
BACKGROUND: To evaluate the effectiveness of binocularity-stimulating treatment in children with residual amblyopia following occlusion therapy for more than 6 months. METHODS: Of patients with amblyopia caused by anisometropia and/or strabismus, patients with residual amblyopia following more than 6 months of occlusion therapy were included. Subjects underwent one of the following types of binocularity-stimulating therapy: Bangerter foil (BF), head-mounted display (HMD) game, or BF/HMD combination (BF + HMD)...
September 20, 2018: BMC Ophthalmology
Qi Wan, Jing Tang, Yu Han, Qibin Xiao, Yingping Deng
BACKGROUND: To report a patient who presented with bluish scleral discoloration, keratoconus, and progressive high myopia. CASE PRESENTATION: A 6-year-old Chinese female patient presented with a significant bluish discoloration of the sclera in both eyes and extreme corneal thinning with anterior corneal protrusion. General pediatric physical examination was normal for all systems and no genetic disorders known were observed. CONCLUSIONS: We aim to highlight the importance of diagnosis and treatment of patients suffering from Brittle cornea syndrome...
September 18, 2018: BMC Ophthalmology
Cassanda C Brooks, James J Augsburger, Zélia M Correa
BACKGROUND: Congenital ocular melanocytosis has been shown to be extremely uncommon in studies of numerous infants and children with retinoblastoma and disorders such as retinopathy of prematurity. CASE PRESENTATION: A 33-month-old Caucasian boy presented with a solid white predominantly endophytic retinoblastoma filling most of the nasal aspect of the fundus and extensive vitreous seeding. Fundus exam of the contralateral eye showed a broad-based flat melanotic area of the choroid extending from the subfoveal region to the ora serrata temporally...
September 17, 2018: BMC Ophthalmology
Xinyi Ding, Ruiping Gu, Meng Zhang, Hui Ren, Qinmeng Shu, Gezhi Xu, Haixiang Wu
BACKGROUND: Attention is increasingly being given to microglia-related inflammation in neovascular diseases, such as diabetic retinopathy and age-related macular disease. Evidence shows that activated microglia contribute to disruption of the blood-retinal barrier, however, the mechanism is unclear. In this study, we aimed to clarify whether and how microglia affect the function of retinal microvascular endothelial cells (RMECs). METHODS: We activated microglia by Lipopolysaccharides (LPS) stimulation...
September 17, 2018: BMC Ophthalmology
Cerys J Evans, Lubica Dudakova, Pavlina Skalicka, Gabriela Mahelkova, Ales Horinek, Alison J Hardcastle, Stephen J Tuft, Petra Liskova
BACKGROUND: The purpose of this study was to identify the genetic cause and describe the clinical phenotype of Schnyder corneal dystrophy (SCD) in six unrelated probands. METHODS: We identified two white Czech, two white British and two South Asian families with a clinical diagnosis of SCD. Ophthalmic assessment included spectral domain optical coherence tomography (SD-OCT) of one individual with advanced disease, and SD-OCT and confocal microscopy of a child with early stages of disease...
September 17, 2018: BMC Ophthalmology
Manabu Miyata, Akio Oishi, Maho Oishi, Tomoko Hasegawa, Hanako Ohashi Ikeda, Akitaka Tsujikawa
BACKGROUND: Retinitis pigmentosa (RP), a neurodegenerative disease, is occasionally accompanied by choroidal neovascularization (CNV) and cystoid macular oedema. It is presently treated with repeated intravitreal injections of anti-vascular endothelial growth factor (VEGF) agents. However, there are concerns regarding long-term inhibition of VEGF by the use of these agents, especially in cases involving neurodegenerative diseases, since VEGFs have a neuroprotective effect. Currently, there are no reports on the long-term safety of anti-VEGF therapy in patients with RP...
September 14, 2018: BMC Ophthalmology
Xiujuan Zhao, Wei Qiu, Yuxin Zhang, Yan Luo, Xiulan Zhang, Lin Lu, Hui Yang
BACKGROUND: Neuromyelitis optica spectrum disorder-optic neuritis (NMOSD-ON) can now be distinguished from other types of ON as a specific disease by the Aquaporin-4 antibody (AQP4-Ab) test. NMOSD-ON can cause severe retinal nerve fiber layer (RNFL) damage. The optical coherence tomography (OCT) characteristics between NMOSD- ON and idiopathic optic neuritis (IDON) were seldom studied in Asians. METHODS: This prospective case-control study involved 152 eyes from 143 optic neuritis (ON) patients...
September 14, 2018: BMC Ophthalmology
Jiao Zhao, Zhike Xu, Aijun Han, Li Zeng, Gengsheng Hao, Bin Chen
BACKGROUND: Dacryoliths in lacrimal gland ductule are a rare condition and an unusual cause of conjunctivitis. Here we report a case with a large lacrimal gland ductule stone with an unique hairy nucleus. CASE PRESENTATION: A 38-year-old female presented with a red left eye for one month. Physical examination revealed an inflammatory granuloma in the lateral canthus and a fistula with purulent secretion. Antibiotics did not ameliorate the symptoms. After we incised the fistula, a huge dacryolith (10 mm × 5 mm × 3 mm) was identified at the end of the dilated lacrimal gland ductule and was removed surgically...
September 12, 2018: BMC Ophthalmology
Shanshan Li, Jiangnan He, Qiuying Chen, Jianfeng Zhu, Haidong Zou, Xun Xu
BACKGROUND: Our study aimed to investigate the ocular surface health of Shanghai University students. METHODS: This is a cross-sectional study carried out among freshmen and sophomores on the main campus of Shanghai University. Questionnaires including the widely-used ocular surface disease index (OSDI) and the Zung Self-rating Anxiety Scale (SAS) were completed first, and then ocular examinations were conducted regarding height & weight, blood pressure and heart rate, optometry, intraocular pressure exam, vision and subjective refraction, Aladdin, Macular pigment density measurement, tear test, anterior segment examination, fundus photography, ophthalmologist check, TOPCON OCT check, and Collin's fundus blood test...
September 12, 2018: BMC Ophthalmology
Constantine D Georgakopoulos, Foteini Tsapardoni, Elli V Kostopoulou, Olga E Makri
BACKGROUND: Deferoxamine (DFO) is one of the most commonly used chelation treatments for transfusional hemosiderosis. Pattern dystrophies constitute a distinct entity of retinal disorders that has been occasionally identified in association with deferoxamine. CASE PRESENTATION: We report two cases of bilateral macular pattern dystrophy in transfusion dependent patients undergoing chronic chelation therapy with deferoxamine due to thalassemias. Our patients were evaluated with multimodal imaging and the results are presented...
September 12, 2018: BMC Ophthalmology
Saki Omatsu, Kazuyuki Hirooka, Eri Nitta, Kaori Ukegawa
BACKGROUND: To compare trabeculectomy and EX-PRESS device implantation procedures for treating glaucoma and evaluate changes in corneal endothelial cell density (CECD). METHODS: This study prospectively evaluated changes in the CECD in 60 eyes of 60 patients who underwent trabeculectomy and 50 eyes of 45 patients who underwent EX-PRESS device implantation. Baseline patient data recorded included age at surgery, sex, type of glaucoma medications, and lens status...
September 10, 2018: BMC Ophthalmology
Lauren R Hepworth, Fiona J Rowe
BACKGROUND: Visual field loss occurs frequently in neurological conditions and perimetry is commonly requested for patients with suspected or known conditions. There are currently no guidelines for how visual fields in neurological conditions should be assessed. There is a wide range of visual field programs available and the wrong choice of program can potentially fail to detect visual field loss. We report the results of a systematic review of the existing evidence base for the patterns of visual field loss in four common neurological conditions and the perimetry programs used, to aid the design of future research and clinical practice guidelines...
September 10, 2018: BMC Ophthalmology
José I Vela, Ivanna Marcantonio, Jesús Díaz-Cascajosa, Jaume Crespí, José A Buil
BACKGROUND: To report our findings in a young patient with unilateral retinitis pigmentosa (RP)-like appearance who developed pigmentary changes in his left retina after an episode of bilateral pars planitis. CASE PRESENTATION: A 17-year-old man presented with 6 months of blurry vision in both eyes. He was diagnosed with bilateral pars planitis. Progressive, intraretinal bone crepuscule pigmentation developed in his left retina during the following three months...
September 10, 2018: BMC Ophthalmology
Yongseok Mun, Ji-Won Kwon, Joo Youn Oh
BACKGROUND: To investigate therapeutic effects of topical diquafosol tetrasodium 3% ophthalmic solution in patients with short tear film break-up time (TFBUT)-type dry eye (DE). METHODS: The prospective study was performed in 70 eyes of 70 patients with short TFBUT-type DE. Diagnosis of short TFBUT-type DE was made based on the presence of DE symptoms, TFBUT value ≤5 s, corneoconjunctival staining score ≤ 2 (on a scale of 0 to 4), and Schirmer I value > 5 mm...
September 5, 2018: BMC Ophthalmology
Huina Zhang, Hongjie Zhou, Tiepei Zhu, Juan Ye
BACKGROUND: To investigate changes in corneal elevation, pachymetry, and keratometry in discriminating between normal and blepharospasm eyes, as measured by the Pentacam rotating Scheimpflug camera. METHODS: This was a prospective, cross-sectional study. A total of 47 consecutive patients with a range of blepharospasm severity and 40 age- and sex- matched healthy subjects were included, one eye of each subject was randomly chosen for data analysis. Blepharospasm severity was evaluated using the Jankovic scale and categorized as mild, moderate, or severe...
September 5, 2018: BMC Ophthalmology
Prithvi Ramtohul, Maëva Chardavoine, Marie Beylerian, Aurore Aziz, Frédéric Matonti, Danièle Denis
BACKGROUND: To describe a unique case of decompression retinopathy manifesting as pre-macular subhyaloid hemorrhage that occurs in a nine-day old child after undergoing a non-penetrating deep sclerectomy for primary congenital glaucoma. CASE PRESENTATION: We report a single case of a 9-day-old boy who was referred to our department of ophthalmology for bilateral buphtalmia and corneal edema. He presented marked elevation of the intraocular pressure in both eyes (22 mmHg and 26 mmHg, in the right eye and left eye respectively) associated with significant optic nerve cupping...
September 5, 2018: BMC Ophthalmology
He Xu, Bo Fu, Chunguang Lu, Li Xu, Jing Sun
BACKGROUND: Endogenous endophthalmitis could lead to a devastating outcome without a prompt and appropriate management. We report a case of advanced endogenous Klebsiella pneumoniae endophthalmitis with extensive subretinal abscess that was successfully treated with a vitrectomy. CASE PRESENTATION: A systemically well 61-year-old man complained of ocular pain and visual decrease in his right eye for eighteen days. Ophthalmic examination showed dense inflammation in the anterior chamber and vitreous body...
September 5, 2018: BMC Ophthalmology
Hatice Ayhan Güler, Nurgül Örnek, Kemal Örnek, Nesrin Büyüktortop Gökçınar, Tevfik Oğurel, Mehmet Erhan Yumuşak, Zafer Onaran
BACKGROUND: To assess corneal endothelial cell changes after intravitreal dexamethasone (DEX) implant (Ozurdex®) injection in patients with macular edema secondary to retinal vein occlusion (RVO). METHODS: Twenty-two eyes of 22 patients were assessed prospectively after intravitreal 0.7 mg DEX implant injection. Twenty-two eyes of 22 healthy volunteers served as control group. Corneal endothelial cell parameters including endothelial cell density (ECD), coefficient of variation of cell size (CV), percentage of hexagonality (Hex) and central corneal thickness (CCT) were analyzed before and 1 and 3 months after injection by specular microscopy...
September 4, 2018: BMC Ophthalmology
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