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BMC Ophthalmology

Xiaoming Huang, Dongrun Tang, Tong Wu, Tianming Jian, Fengyuan Sun
BACKGROUND: To evaluate the ophthalmic manifestations and radiographic features of ectopic orbital meningioma to improve diagnostic accuracy. METHODS: Patient data from patients admitted to our institution during a 217-month period from August 1999 to September 2017 were included. Patient ophthalmic manifestations, radiographic features (CT and MRI), diagnosis, pathology, therapeutic regimens, and prognosis were retrospectively reviewed. RESULTS: Six patients with ectopic orbital meningioma were identified...
November 12, 2018: BMC Ophthalmology
Zikang Xie, Hao Liang
BACKGROUND: Genetic studies have reported contradictory results on the association between the intercellular adhesion molecule-1 (ICAM-1) rs5498 polymorphism and diabetic retinopathy (DR) risk in type 2 diabetic patients. We aimed to perform a systematic literature search and conduct random-effects meta-analysis to provide a quantitative evaluation. METHODS: We searched Pubmed, Embase, Scopus, Web of Science and Wanfang databases from inception up to January 2018...
November 12, 2018: BMC Ophthalmology
Hong-Ying Jin, Ting Wan, Xiao-Ning Yu, Fang Wu, Ke Yao
BACKGROUND: To investigate corneal higher-order aberrations (HOAs) of the anterior surface, posterior surface, and total cornea after small incision lenticule extraction (SMILE) in high myopic and mild to moderate myopic patients. METHODS: This retrospective study included 197 eyes (101 patients) undergoing SMILE surgery. According to the preoperative spherical equivalent (SE), treated eyes were divided into two groups: a high myopic group (more than - 6.0 D, Group H) and a mild to moderate myopic group (less than - 6...
November 12, 2018: BMC Ophthalmology
Meiyan Li, Dong Yang, Feng Zhao, Tian Han, Meng Li, Xingtao Zhou, Katherine Ni
BACKGROUND: To report a first case of lenticule addition and corneal cross-linking for post-LASIK ectasia with associated corneal thinning. CASE PRESENTATION: Lenticule addition followed by corneal cross-linking was performed on the left eye of a patient with post-LASIK ectasia. Postoperatively, the corneal power and elevation were stable with a remarkable improvement in corneal thickness, and the lenticule had merged with the adjacent corneal stroma at 30 months follow-up...
November 12, 2018: BMC Ophthalmology
Na Yeon Jung, Dong Hui Lim, Sung Soon Hwang, Joo Hyun, Tae-Young Chung
BACKGROUND: To compare the clinical outcome of Precizon toric intraocular lens (IOL) (Ophtec Inc.) to that of Tecnis toric IOL (Abbott Medical Optics Inc.). METHODS: This randomized comparative study included 40 eyes (Precizon, 20 eyes; Tecnis, 20 eyes) of 40 patients with visually significant cataract and corneal astigmatism who underwent cataract surgery. Changes in uncorrected distant visual acuity (UCDVA), best corrected distant visual acuity (BCDVA), uncorrected intermediate visual acuity (UCIVA), refraction, residual astigmatism, rotation of the IOL axis, and higher order aberrations at 3 months postoperatively were evaluated...
November 9, 2018: BMC Ophthalmology
Debora Goetz Goldberg, Michael H Goldberg, Riddhi Shah, Jane N Meagher, Haresh Ailani
BACKGROUND: Cataract surgery with pseudophakic mini-monovision has lower out-of-pocket patient expense than premium multifocal intraocular lenses (IOL). The purpose of this study was to evaluate patient-reported satisfaction and spectacle dependence for key activities of daily living after cataract surgery with pseudophakic mini-monovision. The study also examined statistical relationships between patient demographic variables, visual acuity and satisfaction. METHODS: Prospective cohort study of 56 patients (112 eyes) who underwent bilateral cataract surgery with pseudophakic mini-monovision...
November 9, 2018: BMC Ophthalmology
Qingji Li
BACKGROUND: To report "Lamellar Rotation Surgery",a new technique for repairing large and moderate full-thickness upper eyelid defects. METHODS: A two-stage technique is described in which a vertical incision is made in the tarsus of the lower eyelid with elevation of the lateral posterior lamella while sparing the lower eyelid orbicularis and skin to be rotated superiorly to form the reconstructed posterior lamella of the upper eyelid. Additionally, a lateral periosteal flap is used to reconstruct the lateral canthal tendon, and a McGregor procedure is used to reconstruct the anterior lamella of the upper eyelid...
November 7, 2018: BMC Ophthalmology
Je-Hyun Baek, Daehan Lim, Kyu Hyung Park, Jae-Byoung Chae, Hyoik Jang, Jonghyun Lee, Hyewon Chung
BACKGROUND: To identify novel biomarkers related to the pathogenesis of dry age-related macular degeneration (AMD), we adopted a human retinal pigment epithelial (RPE) cell culture model that mimics some features of dry AMD including the accumulation of intra- and sub-RPE deposits. Then, we investigated the aqueous humor (AH) proteome using a data-independent acquisition method (sequential window acquisition of all theoretical fragment ion mass spectrometry) for dry AMD patients and controls...
November 7, 2018: BMC Ophthalmology
Limei Liu, Yi Wang, Ju Liu, Wu Liu
BACKGROUND: To investigate the effect of idiopathic epiretinal membrane (ERM) on the retinal-image quality and psychophysical contrast sensitivity function (CSF). METHODS: Forty-four subjects with diagnosis of idiopathic unilateral ERM were enrolled in this cross-sectional observational clinical study. The fellow unaffected eyes were set as the control group. For retinal-image quality assessment, an Optical Quality Analysis System (OQAS) based on double-pass technique was used to evaluate objective scatter index (OSI) and Strehl ratio...
November 7, 2018: BMC Ophthalmology
Parham Khojasteh, Behzad Aliahmad, Dinesh K Kumar
BACKGROUND: Convolution neural networks have been considered for automatic analysis of fundus images to detect signs of diabetic retinopathy but suffer from low sensitivity. METHODS: This study has proposed an alternate method using probabilistic output from Convolution neural network to automatically and simultaneously detect exudates, hemorrhages and microaneurysms. The method was evaluated using two approaches: patch and image-based analysis of the fundus images on two public databases: DIARETDB1 and e-Ophtha...
November 6, 2018: BMC Ophthalmology
Zhen Li, Zhike Xu, Yaqin Wang, Qiang Liu, Bin Chen
BACKGROUND: The prevalence of primary iris and/or ciliary body cysts is common in myopia, though asymptomatic in nearly all cases. It's a very valuable thing to study the clinical safety and reliability of implantable collamer lens (ICL) surgery in patients with primary iris and/or ciliary body cysts. METHODS: A total of 108 patients (201 eyes) were included in this retrospective study. All eyes had been implanted with V4c implantable collamer lens (ICLV4c). According to the eyes with or without primary iris and/or ciliary body cysts, all eyes were divided into two groups...
November 6, 2018: BMC Ophthalmology
Florence Hoogewoud, Pauline Butori, Philippe Blanche, Antoine P Brézin
BACKGROUND: The early diagnosis of cancer is of crucial importance and a key prognostic factor. Cancer-associated retinopathy (CAR) can be symptomatic prior to other manifestations directly related to malignant tumors. The aim of this study was to show that, in selected cases, ophthalmic findings are consistent enough with the diagnosis of CAR to trigger investigations aimed at detecting a previously unknown malignancy. METHODS: This was a monocentric retrospective case series performed in a tertiary referral center...
November 3, 2018: BMC Ophthalmology
Yasuhiro Iesato, Masaaki Tanaka, Masako Murata, Junya Kitahara, Takao Hirano, Taihei Kurenuma, Noriko Yoshida, Toshinori Murata
BACKGROUND: Polypoidal choroidal vasculopathy (PCV) consists of polyps that potentially cause massive subretinal hemorrhage and their branching vascular network (BVN) of feeder vessels. Although conventional indocyanine green angiography (IA) has shown anti-vascular endothelial growth factor (VEGF) agents and/or photodynamic therapy (PDT) to successfully induce polyp closure, the BVN appears resistant to these therapies and serves as the origin of recurrent active polyps. Recently introduced optical coherence tomography angiography (OCT-A) enables more frequent angiographic evaluation of polyps and the BVN than does conventional IA since it does not require intravenous fluorescent dye injection and is thus considered non-invasive...
November 3, 2018: BMC Ophthalmology
Fan Lu, Aizhu Tao, Weiwei Tao, Xiran Zhuang, Meixiao Shen
BACKGROUND: To investigate thickness changes in the corneal epithelium and Bowman's layer after overnight silicone hydrogel contact lens (CL) wear by using ultra-high resolution optical coherence tomography (UHROCT). METHODS: Eleven subjects without CL wearing history were recruited for this study. An UHROCT was used to measure the thickness of the epithelium (ET), Bowman's layer (BT), stroma (ST), and total cornea (CCT) at the center of both eyes. A silicone hydrogel CL was inserted in the right eye of each subject, and the fellow non-CL wearing left eye served as the control...
November 3, 2018: BMC Ophthalmology
Yan Ma, Guangda Deng, Jing Ma, Jinghua Liu, Songfeng Li, Hai Lu
BACKGROUND: Universal ocular screening of infants is not a standard procedure in children's health care system in China. This pilot study investigated prevalence of ocular abnormalities of 6 weeks-age infants using wide-field digital imaging system. METHODS: Infants aged 6 weeks around were consecutively enrolled in a public hospital between April 2015 and August 2016. All the infants who were enrolled in the study underwent vision assessment, eye position examination, external eye check, pupillary light reflex, red reflex examination, anterior and posterior ocular segments were examined using flashlight, ophthalmoscope, and wide-field digital imaging system...
October 30, 2018: BMC Ophthalmology
Guohong Tian, Weimin Chen, Qian Chen, Min Wang, Guixian Zhao, Zhenxin Li, Jiong Zhang
BACKGROUND: Giant cell arteritis (GCA) is a systemic vasculitis of medium and large-size vessels and can led to permanent visual loss in elderly patients. GCA is very rare among Asians. We report a Chinese patient presenting with acute bilateral anterior ischemic optic neuropathy, and the temporal artery biopsy proved the diagnose of GCA. CASE PRESENTATION: A 77-year-old Chinese man presented with sudden bilateral blindness for 5 days with a severe headache. Funduscopic examination revealed bilateral optic disc swollen with "chalky white" pallid appearance...
October 30, 2018: BMC Ophthalmology
Jacquelyn Daubert, Terrence P O'Brien, Eldad Adler, Oriel Spierer
BACKGROUND: A major obstacle that academic institutions face is the steep learning curve for cornea fellows initially learning to perform Descemet Stripping Endothelial Keratoplasty (DSEK). The purpose of this study is to evaluate the outcomes of complex DSEK performed by cornea fellow supervised by an attending surgeon at an academic institution. METHODS: Patients who underwent a complex DSEK procedure performed by a cornea fellow during the years 2009-2013 were included...
October 30, 2018: BMC Ophthalmology
Taku Toyama, Takashi Ueta, Masato Yoshitani, Rei Sakata, Jiro Numaga
BACKGROUND: Visual acuity (VA) outcomes after phacoemulsification cataract surgery in the very elderly (≥90 years) compared to those in younger patients remain unclear till date. METHODS: We retrospectively investigated 138 (group 1) and 152 (group 2) eyes in patients aged ≥90 and < 80 years, respectively, with senile cataracts who underwent phacoemulsification and intraocular lens implantation between 2014 and 2016. Four highly experienced ophthalmic surgeons performed the procedures...
October 29, 2018: BMC Ophthalmology
Sana' Muhsen, Feras Alkhalaileh, Mohammad Hamdan, Saif Aldeen AlRyalat
BACKGROUND: Central corneal thickness (CCT) has long been implicated to affect glaucoma predisposition. Several reports have identified that thinner CCT is a risk factor for open-angle glaucoma, and that CCT can be very variable between different ethnic groups. In this study, we aim to identify the relation between CCT and different glaucoma parameters in different types of glaucoma in an Arabian ethnicity. METHODS: We classified our participants into four main groups: primary open-angle glaucoma (POAG), primary angle-closure glaucoma (PACG), pseudoexfoliative glaucoma (PXFG), and a control group...
October 29, 2018: BMC Ophthalmology
Mário Luiz R Monteiro, Kenzo Hokazono, Leonardo P Cunha, Laurentino Biccas Neto
BACKGROUND: Sudden visual loss and optic disc edema caused by optic neuritis (ON) is usually followed by significant visual recovery. However, little or no recovery occurs when the loss is caused by atypical ON, especially in patients with neuromyelitis optica (NMO). Optic disc drusen (ODD) is a cause of pseudo optic disc edema and may be a predisposing factor for non-arteritic anterior ischemic optic neuropathy (NAION), thereby mimicking atypical ON. In such cases, if globular concretions are seen protruding from the disc substance, ODD may be suspected...
October 26, 2018: BMC Ophthalmology
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