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BMC Ophthalmology

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https://www.readbyqxmd.com/read/28526015/construction-and-implications-of-structural-equation-modeling-network-for-pediatric-cataract-a-data-mining-research-of-rare-diseases
#1
Erping Long, Shuangjuan Xu, Zhenzhen Liu, Xiaohang Wu, Xiayin Zhang, Jinghui Wang, Wangting Li, Runzhong Liu, Zicong Chen, Kexin Chen, Tongyong Yu, Dongxuan Wu, Xutu Zhao, Jingjing Chen, Zhuoling Lin, Qianzhong Cao, Duoru Lin, Xiaoyan Li, Jingheng Cai, Haotian Lin
BACKGROUND: The majority of rare diseases are complex diseases caused by a combination of multiple morbigenous factors. However, uncovering the complex etiology and pathogenesis of rare diseases is difficult due to limited clinical resources and conventional statistical methods. This study aims to investigate the interrelationship and the effectiveness of potential factors of pediatric cataract, for the exploration of data mining strategy in the scenarios of rare diseases. METHODS: We established a pilot rare disease specialized care center to systematically record all information and the entire treatment process of pediatric cataract patients...
May 19, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28526010/next-generation-sequencing-for-d47n-mutation-in-cx50-analysis-associated-with-autosomal-dominant-congenital-cataract-in-a-six-generation-chinese-family
#2
Chao Shen, Jingbing Wang, Xiaotang Wu, Fuchao Wang, Yang Liu, Xiaoying Guo, Lina Zhang, Yanfei Cao, Xiuhua Cao, Hongxing Ma
BACKGROUND: Congenital cataract is the most frequent cause of blindness during infancy or early childhood. To date, more than 40 loci associated with congenital cataract have been identified, including at least 26 genes on different chromosomes associated with inherited cataract. This present study aimed to identify the genetic mutation in a six-generation Chinese family affected with congenital cataract. METHODS: A detailed six-generation Chinese cataract family history and clinical data of the family members were recorded...
May 19, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28526001/postoperative-full-abduction-in-a-patient-of-duane-retraction-syndrome-without-an-abducens-nerve-a-case-report
#3
Jae Hyoung Kim, Jeong-Min Hwang
BACKGROUND: Duane retraction syndrome (DRS) consists of abduction deficit, globe retraction and upshoots or downshoots with adduction. The abducens nerve on the affected side is absent in type 1 DRS. After bilateral medial rectus muscle recession in unilateral type 1 DRS may improve the abduction limitation, but still more than -3 limitation remains. CASE PRESENTATION: A 6-month-old boy presented with esotropia which had been noticed in early infancy. He showed limited abduction, fissure narrowing on attempted adduction and a small upshoot OS...
May 19, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28514951/a-computerized-red-glass-test-for-quantifying-diplopia
#4
Han Soo Yoo, Eunjeong Park, Soolienah Rhiu, Hyuk-Jae Chang, Kyoungsub Kim, Joonsang Yoo, Ji Hoe Heo, Hyo Suk Nam
BACKGROUND: Accurate evaluation of diplopia during bedside physical examination is challenging. We developed a new computerized red glass test (CRT) to detect, localize, and quantify diplopia and investigated whether the CRT is useful and feasible. METHODS: During the CRT, a white dot randomly appears on a monitor. Because a red glass is applied on the right eye, a patient can see one white dot and one red dot when diplopia is present. We defined the degree of diplopia as the direct distance of the two points with the largest deviation and compared the degree with the Hess score and Hess area ratio...
May 17, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28514944/short-term-visual-outcomes-of-a-new-trifocal-intraocular-lens
#5
Jorge L García-Pérez, Juan Gros-Otero, Celia Sánchez-Ramos, Vanesa Blázquez, Inés Contreras
BACKGROUND: Today, patients often expect to achieve spectacle independance after cataract surgery. New trifocal intraocular lenses have been developed to try and fullfill this demand. The purpose of this study is to report the short-term visual outcomes of a new trifocal intraocular lens (AcrySof PanOptix™). METHODS: Consecutive adult patients undergoing cataract surgery with bilateral implantation of the study intraocular lens in a private practice clinic were considered for inclusion...
May 17, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28514942/corneal-biomechanical-properties-in-healthy-children-measured-by-corneal-visualization-scheimpflug-technology
#6
Miao He, Hui Ding, Hong He, Chi Zhang, Liangping Liu, Xingwu Zhong
BACKGROUND: The aim of this study was to evaluate corneal biomechanical properties in a population of healthy children in China using corneal visualization Scheimpflug technology (CST). METHODS: All children underwent complete bi-ocular examinations. CST provided intraocular pressure (IOP) and corneal biomechanical parameters, including time, velocity, length and deformation amplitude at first applanation (A1T, A1V, A1L, A1DA), at second applanation (A2T, A2V, A2L, A2DA), highest concavity time (HCT), maximum deformation amplitude (MDA), peak distance (PD), and radius of curvature (RoC)...
May 17, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28511643/long-noncoding-rna-expression-profile-in-hle-b-3-cells-during-tgf-%C3%AE-2-induced-epithelial-mesenchymal-transition
#7
Bingyu Zhang, Yang Chen, Meiyuan Qiu, Zhixiang Ding
BACKGROUND: Recent evidence has shown that long noncoding RNAs (lncRNAs) are involved in the process of epithelial-mesenchymal transition (EMT). However, little research has focused on the expression profile of lncRNAs during EMT in human lens epithelial cells (LECs) and their functions have not yet been described. METHODS: Dysregulated lncRNAs and mRNAs in normal human lens epithelial B-3(HLE B-3) cells and during transforming growth factor β2(TGF-β2)-induced EMT were analyzed via lncRNA microarray...
May 16, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28506260/atypical-retinal-pigment-epithelial-defects-with-retained-photoreceptor-layers-a-so-far-disregarded-finding-in-age-related-macular-degeneration
#8
Helena Giannakaki-Zimmermann, Giuseppe Querques, Inger Christine Munch, Daraius Shroff, David Sarraf, Xuejing Chen, Eduardo Cunha-Souza, Sarah Mrejen, Vittorio Capuano, Murilo W Rodrigues, Charu Gupta, Andreas Ebneter, Martin S Zinkernagel, Marion R Munk
BACKGROUND: To report patients with age-related macular degeneration and atypical central retinal pigment epithelium (RPE) defects not attributable to geographic atrophy (GA) or RPE-tears with overlying preserved photoreceptor layers. METHODS: Multimodal imaging case-series evaluating the course of atypical RPE- defects in patients with AMD using Color fundus images, Optical coherence tomography (OCT), OCT-Angiography, fundus autofluorescence (FAF) and fluorescein-angiography (FA)...
May 15, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28506223/case-of-asteroid-hyalosis-that-developed-severely-reduced-vision-after-cataract-surgery
#9
Ryosuke Ochi, Bumpei Sato, Seita Morishita, Yukihiro Imagawa, Masashi Mimura, Masanori Fukumoto, Takaki Sato, Takatoshi Kobayashi, Teruyo Kida, Tsunehiko Ikeda
BACKGROUND: To report our findings in a patient with asteroid hyalosis (AH) who had a severe reduction of his visual acuity following cataract surgery. The vision was improved by vitreous surgery. CASE PRESENTATION: The patient was an 81-year-old man. Following cataract surgery on his left eye, his decimal best-corrected visual acuity (BCVA) was markedly reduced from 0.2 to 0.02. A large number of asteroid bodies (ABs) was observed to be concentrated on the posterior surface of the implanted intraocular lens...
May 15, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28499445/vision-related-quality-of-life-following-glaucoma-filtration-surgery
#10
Kazuyuki Hirooka, Eri Nitta, Kaori Ukegawa, Akitaka Tsujikawa
BACKGROUND: To evaluate vision-related quality of life (VR-QOL) following glaucoma filtration surgery. METHODS: A total of 103 glaucoma patients scheduled to undergo glaucoma filtration surgery. Prior to and at three months after glaucoma filtration surgery, trabeculectomy or EX-PRESS, all patients completed the 25-item National Eye Institute Visual Function Questionnaire (VFQ-25). A total of 48 patients underwent combined cataract and filtration surgery. The clinical data collected pre- and postoperatively included best-corrected visual acuity (BCVA) and intraocular pressure (IOP)...
May 12, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28499427/pars-plana-vitrectomy-with-partial-tamponade-of-filtered-air-in-rhegmatogenous-retinal-detachment-caused-by-superior-retinal-breaks
#11
Zhaotian Zhang, Manjuan Peng, Yantao Wei, Xintong Jiang, Shaochong Zhang
BACKGROUND: To investigate the anatomic and functional outcomes of pars plana vitrectomy (PPV) with partial tamponade of filtered air for rhegmatogenous retinal detachment (RRD) caused by superior retinal breaks. METHODS: Retrospective, comparative, consecutive case series study. Patients with RRD caused by superior retinal breaks undergone PPV with partial tamponade (Group A) and whole tamponade (Group B) of filtered air were included. The main outcomes were primary and final success rates, best corrected visual acuity (BCVA), and rate of postoperative cataract surgery...
May 12, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28499410/comparison-of-the-acute-ocular-manifestations-of-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-in-chinese-eyes-a-15-year-retrospective-study
#12
Loraine L W Chow, Kendrick C Shih, Johnny C Y Chan, Jimmy S M Lai, Alex L K Ng
BACKGROUND: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening conditions that initially affect the skin and mucous membranes. The aim of this study was to compare the acute ocular manifestations between SJS and TEN. METHODS: The initial presenting ophthalmic records of patients with either SJS (<30% body surface area involvement) or TEN (> = 30% involvement), who were treated at one tertiary burn center in Hong Kong between 1999 and 2014, were retrospectively analyzed and compared...
May 12, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28482825/effect-of-limbal-relaxing-incisions-during-implantable-collamer-lens-surgery
#13
Zhen Li, Yu Han, Budan Hu, Huibin Du, Gengsheng Hao, Xiaoxi Chen
BACKGROUND: The limbal relaxing incisions (LRIs) technique is a safe and an inexpensive procedure, which is simple for experts to perform. It can effectively reduce astigmatism and result in a rapid visual rehabilitation. But there are few reports about reducing pre-existing corneal astigmatism by LRI in ICL surgery. Our research was aimed to study the effect of limbal relaxing inci sions during implantable collamer lens (ICL) surgery. METHODS: A prospective analysis reviewing consecutive cases of corneal astigmatism that had either independent ICL surgery (control group) or combined with LRIs (LRIs group)...
May 8, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28464806/the-effect-of-ocular-biometric-factors-on-the-accuracy-of-various-iol-power-calculation-formulas
#14
Jinho Jeong, Han Song, Jimmy K Lee, Roy S Chuck, Ji-Won Kwon
BACKGROUND: To evaluate how differences in ocular biometry affects the Hoffer Q, Holladay 1, SRK/T, and Haigis intraocular lens power calculation formulae predictions. METHODS: This study was performed on 91 eyes of 91 patients who underwent uneventful cataract surgery. Ocular biometry values were measured using the IOL Master 500, and intraocular lens (IOL) power was calculated using the Haigis, Hoffer Q, Holladay 1, and SRK/T formulas. We calculated the expected difference (ED) of each 3rd generation formula from the Haigis formula by subtracting the predicted refraction of the Haigis formula from the predicted refraction of each 3rd generation formula...
May 2, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28454526/efficacy-and-tolerability-of-preservative-free-0-0015-tafluprost-in-glaucoma-patients-a-prospective-crossover-study
#15
Wonseok Lee, Sunghoon Lee, HyoungWon Bae, Chan Yun Kim, Gong Je Seong
BACKGROUND: The aim of this work is to evaluate efficacy and tolerability of preservative containing 0.0015% tafluprost and preservative-free 0.0015% tafluprost using a prospective crossover study. METHODS: Primary open angle glaucoma (POAG) and normotensive glaucoma (NTG) patients were randomized enrolled. Group 1 ("NPT to PT") patients used preservative-free 0.0015% tafluprost (NPT) for 6 months and then changed to preservative containing 0.0015% tafluprost(PT) for 6 months...
April 28, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28449645/24-month-clinical-outcomes-of-a-treat-and-extend-regimen-with-ranibizumab-for-wet-age-related-macular-degeneration-in-a-real-life-setting
#16
Athanasios Vardarinos, Nitin Gupta, Raazia Janjua, Abigail Iron, Theo Empeslidis, Konstantinos T Tsaousis
BACKGROUND: To evaluate the clinical effectiveness and analyze the outcomes of a treat-and-extend (T&E) treatment regimen with ranibizumab for wet age-related macular degeneration (ARMD) in real life clinical settings over the first 2 years (24 months) of treatment. METHODS: Retrospective analysis of visual acuity, spectral domain optical coherence tomography (SD-OCT) parameters and treatment burden data of 56 eyes of 54 unselected treatment naive patients diagnosed with exudative ARMD...
April 27, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28449640/cd34-tumours-of-the-orbit-including-solitary-fibrous-tumours-a-six-case-series
#17
Su Kyung Jung, Ji Sun Paik, Gyeong Sin Park, Suk-Woo Yang
BACKGROUND: To report six cases of CD34+ fibroblastic mesenchymal tumours, which are uncommon neoplasms in the orbit. CASE PRESENTATION: Six patients presenting with proptosis and palpable mass who were later diagnosed with fibrous solitary tumours, fibrous histocytoma or haemangiopericytoma in the orbit were included. All patients received radiologic examinations and surgical excision for histopathology and immunohistochemistry examinations. Five patients had no recurrence after a minimum follow-up of 12 months...
April 27, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28446167/evaluation-of-biometry-and-corneal-astigmatism-in-cataract-surgery-patients-from-central-china
#18
Ji-Guo Yu, Jie Zhong, Zhong-Ming Mei, Fang Zhao, Na Tao, Yi Xiang
BACKGROUND: To evaluate the distribution of biometric parameters and corneal astigmatism using the IOLMaster device before phacoemulsification in cataract patients in Central China. METHODS: Consecutive cataract patients were recruited at the Central Hospital of Wuhan between January 2015 and June 2016. Ocular axial length (AL), keratometry values, anterior chamber depth (ACD) and horizontal corneal diameter (white to white [WTW]) of each cataract-affected eye were measured with the IOLMaster device...
April 26, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28446156/conjunctival-granuloma-with-necrosis-associated-with-exposed-suture-in-upper-double-lid-masquerading-as-ocular-surface-squamous-neoplasia-a-case-report
#19
Yu Jeong Kim, Jaeyoung Kim, Hokyung Choung, Mee Kum Kim, Won Ryang Wee
BACKGROUND: This study reports two cases of conjunctival granuloma with necrosis caused by an exposed suture in the upper palpebral conjunctiva masquerading as ocular surface squamous neoplasia. CASE PRESENTATION: Two patients presented with chronic conjunctival ulcerative and granulomatous lesions on the superior bulbar conjunctiva that repeatedly recurred after the mass was removed. The pathologic findings revealed the absence of malignant cells and presence of many lymphocytes, plasma cells, and histiocytes...
April 26, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28446148/circumpapillary-retinal-nerve-fiber-layer-thickness-anterior-lamina-cribrosa-depth-and-lamina-cribrosa-thickness-in-neovascular-glaucoma-secondary-to-proliferative-diabetic-retinopathy-a-cross-sectional-study
#20
Satoshi Yokota, Yuji Takihara, Yoshihiro Takamura, Masaru Inatani
BACKGROUND: To compare the lamina cribrosa between eyes with and without neovascular glaucoma (NVG) using enhanced depth imaging spectral-domain optical coherence tomography. METHODS: Forty-six patients with proliferative diabetic retinopathy were enrolled in this cross-sectional study. The patients were divided into two groups based on the absence or presence of NVG (the non-NVG group and the NVG group, respectively). The intraocular pressure (IOP), circumpapillary retinal nerve fiber layer (cpRNFL) thickness, anterior lamina cribrosa depth (ALD), and laminar thickness (LT) were compared between the groups...
April 26, 2017: BMC Ophthalmology
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