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BMC Cancer

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https://www.readbyqxmd.com/read/29221446/a-systematic-review-of-test-accuracy-studies-evaluating-molecular-micro-satellite-instability-testing-for-the-detection-of-individuals-with-lynch-syndrome
#1
Helen Coelho, Tracey Jones-Hughes, Tristan Snowsill, Simon Briscoe, Nicola Huxley, Ian M Frayling, Chris Hyde
BACKGROUND: A systematic review was conducted to assess the diagnostic test accuracy of polymerase chain reaction (PCR)-based microsatellite instability (MSI) testing for identifying Lynch syndrome in patients with colorectal cancer (CRC). Unlike previous reviews, this was based on assessing MSI testing against best practice for the reference standard, and included CRC populations that were unselected, age-limited or high-risk for Lynch syndrome. METHODS: Single- and two-gate diagnostic test accuracy studies, or similar, were identified, assessed for inclusion, data extracted and quality appraised by two reviewers according to a pre-specified protocol...
December 8, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29221445/study-protocol-of-hgcsg1404-snow-study-a-phase-i-ii-trial-of-combined-chemotherapy-of-s-1-nab-paclitaxel-and-oxaliplatin-administered-biweekly-to-patients-with-advanced-gastric-cancer
#2
Yasuyuki Kawamoto, Yoshito Komatsu, Satoshi Yuki, Kentaro Sawada, Tetsuhito Muranaka, Kazuaki Harada, Hiroshi Nakatsumi, Hiraku Fukushima, Atsushi Ishiguro, Masayoshi Dazai, Kazuteru Hatanaka, Michio Nakamura, Ichiro Iwanaga, Minoru Uebayashi, Susumu Sogabe, Yoshimitsu Kobayashi, Takuto Miyagishima, Kota Ono, Naoya Sakamoto, Yuh Sakata
BACKGROUND: In Japan, S-1 plus cisplatin (SP) regimen has become a standard therapy for patients with advanced gastric cancer. Moreover, the S-1 plus oxaliplatin regimen is now a standard treatment. Nab-paclitaxel was developed for chemotherapy of gastric cancer in Japanese clinical practice. Nab-paclitaxel, created with albumin-bound paclitaxel particles, has high transferability to tumour tissues and does not cause hypersensitivity reactions because of a different chemical composition compared with docetaxel and paclitaxel...
December 8, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29216866/cross-sectional-study-of-serum-selenium-concentration-and-esophageal-squamous-dysplasia-in-western-kenya
#3
Natalie R Pritchett, Stephen L Burgert, Gwen A Murphy, John D Brockman, Russell E White, Justus Lando, Robert Chepkwony, Mark D Topazian, Christian C Abnet, Sanford M Dawsey, Michael M Mwachiro
BACKGROUND: Low serum selenium status has been associated with increased risk of esophageal squamous cell carcinoma (ESCC). East Africa is a region of high ESCC incidence and is known to have low soil selenium levels, but this association has not previously been evaluated. In this study we assessed the association of serum selenium concentration and the prevalence of esophageal squamous dysplasia (ESD), the precursor lesion of ESCC, in a cross-sectional study of subjects from Bomet, Kenya...
December 8, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29216863/ccl5-ccr5-interactions-modulate-metabolic-events-during-tumor-onset-to-promote-tumorigenesis
#4
Darrin Gao, Lisa H Cazares, Eleanor N Fish
BACKGROUND: In earlier studies we have shown that CCL5 activation of CCR5 induces the proliferation and survival of breast cancer cells in a mechanistic target of rapamycin (mTOR)-dependent manner and that this is in part due to CCR5-mediated increases in glycolytic metabolism. METHODS: Using the MDA-MB-231 triple negative human breast cancer cell line and mouse mammary tumor virus - polyomavirus middle T-antigen (MMTV-PyMT) mouse primary breast cancer cells, we conducted in vivo tumor transplant experiments to examine the effects of CCL5-CCR5 interactions in the context of regulating tumor metabolism...
December 8, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29216916/low-level-laser-therapy-photobiomodulation-therapy-for-breast-cancer-related-lymphedema-a-systematic-review
#5
G David Baxter, Lizhou Liu, Simone Petrich, Angela Spontelli Gisselman, Cathy Chapple, Juanita J Anders, Steve Tumilty
BACKGROUND: Breast cancer related lymphedema (BCRL) is a prevalent complication secondary to cancer treatments which significantly impacts the physical and psychological health of breast cancer survivors. Previous research shows increasing use of low level laser therapy (LLLT), now commonly referred to as photobiomodulation (PBM) therapy, for BCRL. This systematic review evaluated the effectiveness of LLLT (PBM) in the management of BCRL. METHODS: Clinical trials were searched in PubMed, AMED, Web of Science, and China National Knowledge Infrastructure up to November 2016...
December 7, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29216867/protein-kinase-c-%C3%AE-enhances-migration-of-breast-cancer-cells-through-foxc2-mediated-repression-of-p120-catenin
#6
Thao N D Pham, Bethany E Perez White, Huiping Zhao, Fariborz Mortazavi, Debra A Tonetti
BACKGROUND: Despite recent advances in the diagnosis and treatment of breast cancer, metastasis remains the main cause of death. Since migration of tumor cells is considered a prerequisite for tumor cell invasion and metastasis, a pressing goal in tumor biology has been to elucidate factors regulating their migratory activity. Protein kinase C alpha (PKCα) is a serine-threonine protein kinase implicated in cancer metastasis and associated with poor prognosis in breast cancer patients...
December 7, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29212535/leukocytoclastic-vasculitis-complicating-cisplatin-radiation-treatment-for-laryngeal-cancer-a-case-report
#7
Júlia Coelho França Quintanilha, Marília Berlofa Visacri, Laís Sampaio Amaral, Carmen Silvia Passos Lima, Maria Letícia Cintra, Patricia Moriel
BACKGROUND: Leukocytoclastic vasculitis is typically mediated by deposition of immune complexes and is related to many causes, including medication. To the best of our knowledge, leukocytoclastic vasculitis related to cisplatin has not yet been described in the scientific literature. CASE PRESENTATION: We report a rare case of leukocytoclastic vasculitis after the first cycle of high-dose cisplatin chemotherapy in a patient with larynx carcinoma. A 48-year-old Caucasian man with larynx carcinoma received a high-dose of cisplatin monochemotherapy (100 mg/m2 every 21 days), along with 70 Gy of radiotherapy divided into 35 sessions, as a therapeutic schedule...
December 6, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29212455/comparative-gene-co-expression-network-analysis-of-epithelial-to-mesenchymal-transition-reveals-lung-cancer-progression-stages
#8
Daifeng Wang, John D Haley, Patricia Thompson
BACKGROUND: The epithelial to mesenchymal transition (EMT) plays a key role in lung cancer progression and drug resistance. The dynamics and stability of gene expression patterns as cancer cells transition from E to M at a systems level and relevance to patient outcomes are unknown. METHODS: Using comparative network and clustering analysis, we systematically analyzed time-series gene expression data from lung cancer cell lines H358 and A549 that were induced to undergo EMT...
December 6, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29207975/radiomics-based-analysis-to-predict-local-control-and-survival-in-hepatocellular-carcinoma-patients-treated-with-volumetric-modulated-arc-therapy
#9
Luca Cozzi, Nicola Dinapoli, Antonella Fogliata, Wei-Chung Hsu, Giacomo Reggiori, Francesca Lobefalo, Margarita Kirienko, Martina Sollini, Davide Franceschini, Tiziana Comito, Ciro Franzese, Marta Scorsetti, Po-Ming Wang
BACKGROUND: To appraise the ability of a radiomics based analysis to predict local response and overall survival for patients with hepatocellular carcinoma. METHODS: A set of 138 consecutive patients (112 males and 26 females, median age 66 years) presented with Barcelona Clinic Liver Cancer (BCLC) stage A to C were retrospectively studied. For a subset of these patients (106) complete information about treatment outcome, namely local control, was available. Radiomic features were computed for the clinical target volume...
December 6, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29207970/overexpression-of-cullin7-is-associated-with-hepatocellular-carcinoma-progression-and-pathogenesis
#10
Jun An, Zhigang Zhang, Zhiyong Liu, Ruizhi Wang, Dayang Hui, Yi Jin
BACKGROUND: Overexpression of Cullin7 is associated with some types of malignancies. However, the part of Cullin7 in hepatocellular carcinoma remains unclear. The aim of this study was to investigate the role of Cullin7 in pathogenesis and the progression of hepatocellular carcinoma. METHODS: In the present study, the expression of Cullin7 in hepatocellular carcinoma cell lines and five surgical hepatocellular carcinoma specimens was detected with quantitative reverse transcription PCR and western blotting...
December 6, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29207966/study-protocol-for-a-cluster-randomized-trial-to-compare-human-papillomavirus-based-cervical-cancer-screening-in-community-health-campaigns-versus-health-facilities-in-western-kenya
#11
Megan J Huchko, James G Kahn, Jennifer S Smith, Robert A Hiatt, Craig R Cohen, Elizabeth Bukusi
BACKGROUND: Despite guidelines for cervical cancer prevention in low-resource countries, a very small proportion of women in these settings undergo screening, and even fewer women are successfully treated. Using pilot data from western Kenya and World Health Organization recommendations, we developed a protocol to implement evidence-based cervical cancer screening and linkage to treatment strategies to the rural communities. We describe the protocol for a cluster-randomized trial to compare two implementation strategies for human-papillomavirus (HPV)-based cervical cancer screening program using metrics described in the RE-AIM (reach, efficacy, adaption, implementation and maintenance) framework...
December 6, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29207964/concordance-of-fdg-pet-ct-metabolic-tumour-volume-versus-dw-mri-functional-tumour-volume-with-t2-weighted-anatomical-tumour-volume-in-cervical-cancer
#12
Alta Y T Lai, Jose A U Perucho, Xiaopei Xu, Edward S Hui, Elaine Y P Lee
BACKGROUND: 18F-fluoro-deoxyglucose positron emission tomography with computed tomography (FDG PET/CT) has been employed to define radiotherapy targets using a threshold based on the standardised uptake value (SUV), and has been described for use in cervical cancer. The aim of this study was to evaluate the concordance between the metabolic tumour volume (MTV) measured on FDG PET/CT and the anatomical tumour volume (ATV) measured on T2-weighted magnetic resonance imaging (T2W-MRI); and compared with the functional tumour volume (FTV) measured on diffusion-weighted MRI (DW-MRI) in cervical cancer, taking the T2W-ATV as gold standard...
December 6, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29207960/decreased-expression-of-the-%C3%AE-2-integrin-on-tumor-cells-is-associated-with-a-reduction-in-liver-metastasis-of-colorectal-cancer-in-mice
#13
Aitor Benedicto, Joana Marquez, Alba Herrero, Elvira Olaso, Elzbieta Kolaczkowska, Beatriz Arteta
BACKGROUND: Lymphocyte Function-Associated Antigen-1 (LFA-1; CD18/CD11a) is one of the main adhesion molecules used by immune cells to infiltrate the liver under inflammatory conditions. Recently, the expression of this integrin has also been reported on several solid tumors, including colorectal cancer. However, its functional role in the metastatic progression to the liver remains unknown. Using in vitro assays and an experimental orthotopic in vivo model of liver metastasis, we aimed to elucidate the role of tumor LFA-1 in the metastatic progression by means of the partial depletion of the β2 subunit of LFA-1, required for integrin activation, firm adhesion and signaling...
December 6, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29207990/relevance-of-matrix-metalloproteases-in-non-small-cell-lung-cancer-diagnosis
#14
Sonia Blanco-Prieto, Leticia Barcia-Castro, María Páez de la Cadena, Francisco Javier Rodríguez-Berrocal, Lorena Vázquez-Iglesias, María Isabel Botana-Rial, Alberto Fernández-Villar, Loretta De Chiara
BACKGROUND: The need for novel biomarkers that could aid in non-small cell lung cancer (NSCLC) detection, together with the relevance of Matrix Metalloproteases (MMPs) -1, -2, -7, -9 and -10 in lung tumorigenesis, prompted us to assess the diagnostic usefulness of these MMPs and the Tissue Inhibitor of Metalloproteinase (TIMP) -1 in NSCLC patients. METHODS: Markers were evaluated in an initial study cohort (19 NSCLC cases and 19 healthy controls). Those that better performed were analyzed in a larger sample including patients with benign lung diseases...
December 5, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29207971/comparison-of-the-association-of-mammographic-density-and-clinical-factors-with-ductal-carcinoma-in-situ-versus-invasive-ductal-breast-cancer-in-korean-women
#15
Hyeonyoung Ko, Jinyoung Shin, Jeong Eon Lee, Seok Jin Nam, Tuong Linh Nguyen, John Llewelyn Hopper, Yun-Mi Song
BACKGROUND: In spite of the increasing incidence of in situ breast cancer, the information about the risk factors of in situ breast cancer (DCIS) is scarce as compared to the information available for invasive ductal breast cancer (IDC), with inconsistent findings regarding the difference in risk factors between DCIS and IDC. METHODS: We enrolled 472 women with IDC and 90 women with DCIS and 1088 controls matching for age and menopausal status. Information on risk factors was collected through self-administered questionnaire...
December 5, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29207962/a-partially-supervised-physical-activity-program-for-adult-and-adolescent-survivors-of-childhood-cancer-surfit-study-design-of-a-randomized-controlled-trial-nct02730767
#16
Corina S Rueegg, Susi Kriemler, Simeon J Zuercher, Christina Schindera, Andrea Renner, Helge Hebestreit, Christian Meier, Prisca Eser, Nicolas X von der Weid
BACKGROUND: Beyond survival of nowadays >80%, modern childhood cancer treatment strives to preserve long-term health and quality of life. However, the majority of today's survivors suffer from short- and long-term adverse effects such as cardiovascular and pulmonary diseases, obesity, osteoporosis, fatigue, depression, and reduced physical fitness and quality of life. Regular exercise can play a major role to mitigate or prevent such late-effects. Despite this, there are no data on the effects of regular exercise in childhood cancer survivors from randomized controlled trials (RCTs)...
December 5, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29207959/insulin-like-growth-factor-receptor-and-sphingosine-kinase-are-prognostic-and-therapeutic-targets-in-breast-cancer
#17
Aleksandra M Ochnik, Robert C Baxter
BACKGROUND: Targeting the type 1 insulin-like growth factor receptor (IGF1R) in breast cancer remains an ongoing clinical challenge. Oncogenic IGF1R-signaling occurs via activation of PI3K/AKT/MAPK downstream mediators which regulate cell proliferation and protein synthesis. To further understand IGF1R signaling we have investigated the involvement of the oncogenic IGF1R-related sphingosine kinase (SphK) pathway. METHODS: The prognostic (overall survival, OS) and therapeutic (anti-endocrine therapy) co-contribution of IGF1R and SphK1 were investigated using breast cancer patient samples (n = 236) for immunohistochemistry to measure total and phosphorylated IGF1R and SphK1...
December 5, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29207944/incidence-of-breast-cancer-in-chinese-women-exposed-to-the-1959-1961-great-chinese-famine
#18
Dandan He, Yuan Fang, Marc J Gunter, Dongli Xu, Yanping Zhao, Jie Zhou, Hong Fang, Wang Hong Xu
BACKGROUND: The association of malnutrition in early life with breast cancer risk has been studied in Europe by investigating survivors of the Dutch Hunger Winter Famine, but not in China. We evaluated the effect of exposure to the 1959-1961 Great Leap Forward famine on subsequent breast cancer risk in Chinese women. METHODS: A total of 59,060 women born in 1955~1966 were recruited from Minhang district, Shanghai, China, during the period 2008 to 2012. A baseline survey was conducted to collect demographic characteristics and known risk factors for breast cancer...
December 5, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29202805/clinical-significance-of-pcdh10-promoter-methylation-in-diffuse-large-b-cell-lymphoma
#19
Wenting Huang, Xuemin Xue, Ling Shan, Tian Qiu, Lei Guo, Jianming Ying, Ning Lu
BACKGROUND: PCDH10, one of the non-clustered protocadherins, is identified as a tumor suppressor gene in many tumors. Recently, promoter methylation of PCDH10 was found in diffuse large B-cell lymphoma (DLBCL) but not in normal lymph nodes, suggesting that its epigenetic aberrance is essential to the lymphomagenesis. However, there are few studies on the clinicopathological relevance and prognostic significance of PCDH10 methylation status in DLBCL. METHODS: One hundred-seven cases of DLBCL between Jan 2009 and Jul 2010 were selected to extract genomic DNA and perform bisulfite modification...
December 4, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29202800/genistein-induces-apoptosis-of-colon-cancer-cells-by-reversal-of-epithelial-to-mesenchymal-via-a-notch1-nf-%C3%AE%C2%BAb-slug-e-cadherin-pathway
#20
Panpan Zhou, Chunling Wang, Zebin Hu, Wenruo Chen, Wentao Qi, Aike Li
BACKGROUND: Genistein has been known to inhibit proliferation and induce apoptosis in several kinds of cancer cells. While knowledge of genistein in regulating epithelial mesenchymal transition (EMT) of colon cancer cells is unknown. METHODS: To investigate the effects and mechanisms of genistein on EMT of colon cancer cells, HT-29 cells were used and treated by genistein and TNF-α in this paper. EMT was determined by cell invasion assays using a transwell chamber and the expression changes of EMT-related markers were confirmed by RT-PCR, Western blotting, and immunofluorescence staining...
December 4, 2017: BMC Cancer
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