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BMC Cancer

Marco Tomasetti, Massimo Re, Federica Monaco, Simona Gaetani, Corrado Rubini, Andrea Bertini, Ernesto Pasquini, Cristiana Bersaglieri, Massimo Bracci, Sara Staffolani, Mariastella Colomba, Armando Gregorini, Matteo Valentino, Adriano Tagliabracci, Massimo Bovenzi, Jiri Neuzil, Monica Amati, Lory Santarelli
BACKGROUND: Intestinal-type sinonasal adenocarcinomas (ITACs) are aggressive malignancies related to wood dust and leather exposure. ITACs are generally associated with advanced stage at presentation due to the insidious growth pattern and non-specific symptoms. Therefore, biomarkers that can detect the switch from the benign disease to malignancy are needed. Essential for tumour growth, angiogenesis is an important step in tumour development and progression. This process is strictly regulated, and MiR-126 considered its master modulator...
September 17, 2018: BMC Cancer
Katrien Vandecasteele, Philippe Tummers, Mieke Van Bockstal, Pieter De Visschere, Tom Vercauteren, Werner De Gersem, Hannelore Denys, Eline Naert, Amin Makar, Wilfried De Neve
BACKGROUND: Definitive chemoradiotherapy is standard of care in locally advanced cervical cancer (LACC). Both toxicity and local relapse remain major concerns in this treatment. We hypothesize that a magnetic resonance imaging (MRI) based redefining of the radiotherapeutic target volume will lead to a reduction of acute and late toxicity. In our center, chemoradiotherapy followed by hysterectomy was implemented successfully in the past. This enables us to assess the safety of reducing the target volume but also to explore the biological effects of chemoradiation on the resected hysterectomy specimen...
September 17, 2018: BMC Cancer
J Mark Elwood, Essa Tawfiq, Sandar TinTin, Roger J Marshall, Tung M Phung, Ian Campbell, Vernon Harvey, Ross Lawrenson
BACKGROUND: The only available predictive models for the outcome of breast cancer patients in New Zealand (NZ) are based on data in other countries. We aimed to develop and validate a predictive model using NZ data for this population, and compare its performance to a widely used overseas model, the Nottingham Prognostic Index (NPI). METHODS: We developed a model to predict 10-year breast cancer-specific survival, using data collected prospectively in the largest population-based regional breast cancer registry in NZ (Auckland, 9182 patients), and assessed its performance in this data set (internal validation) and in an independent NZ population-based series of 2625 patients in Waikato (external validation)...
September 17, 2018: BMC Cancer
Zhihua Yin, Zhigang Cui, Hang Li, Juan Li, Baosen Zhou
BACKGROUND: Long non-coding RNA (lncRNA) H19 is a hot spot in tumor development, progression and metastasis. This study assessed the association between H19 genetic polymorphisms and the susceptibility of lung cancer. METHODS: The case-control study was conducted to evaluate the association between four selected single nucleotide polymorphisms (rs217727, rs2107425, rs2735469 and rs17658052) in H19 gene and the risk of lung cancer. There were 556 female never smoking lung cancer patients and 395 cancer-free controls...
September 15, 2018: BMC Cancer
Valesca P Retèl, Lotte M G Steuten, Marnix H Geukes Foppen, Janne C Mewes, Melanie A Lindenberg, John B A G Haanen, Wim H van Harten
BACKGROUND: An emerging immunotherapy is infusion of tumor infiltrating Lymphocytes (TIL), with objective response rates of around 50% versus 19% for ipilimumab. As an Advanced Therapeutic Medicinal Products (ATMP), TIL is highly personalized and complex therapy. It requests substantial upfront investments from the hospital in: expensive lab-equipment, staff expertise and training, as well as extremely tight hospital logistics. Therefore, an early health economic modelling study, as part of a Coverage with Evidence Development (CED) program, was performed...
September 15, 2018: BMC Cancer
Fengqiong Liu, Ruijie Gong, Baochang He, Fa Chen, Zhijian Hu
BACKGROUND: Pseudogenes are RNA transcripts with high homology with its parent protein-coding genes. Although pseudogenes lost the ability to produce protein, it still exert import biological function, and play important role in the pathogenesis of a wide varity of tumors; However, the role of pseudogenes in esophageal squamous cell carcinoma (ESCC) is poorly understood. METHODS: TUSC2P function in ESCC were explored using both in vitro and in vivo experiments cell proliferation, invasion and apoptosis assay was performed to evaluated the effect of TUSC2P on the tumor biology of ESCC...
September 15, 2018: BMC Cancer
Zineb Benbrahim, Teresita Antonia, Nawfel Mellas
BACKGROUND: Our goal was to investigate the prevalence of the epidermal growth factor receptor (EGFR) mutation in Middle East and African countries and to compare its prevalence with that shown in other populations. METHODS: We used PubMed and the Cochrane Library databases to conduct a literature search using the terms "[EGFR] AND [mutation] AND [Non Small Cell Lung Cancer] AND [Middle East OR Africa]." We assessed studies published in English and French from 2004 until 2016...
September 14, 2018: BMC Cancer
A L McCarthy, N M Peel, K M Gillespie, R Berry, E Walpole, P Yates, R E Hubbard
BACKGROUND: Frailty is an indicator of physiological reserve in older people. In non-cancer settings, frailty indices are reliable predictors of adverse health outcomes. The aims of this study were to 1) derive and validate a frailty index (FI) from comprehensive geriatric assessment (CGA) data obtained in the solid tumour chemotherapy setting, and 2) to explore whether the FI-CGA could predict chemotherapy decisions and survival in older cancer patients with solid tumours. METHODS: Prospective cohort study of a consecutive series sample of 175 cancer patients aged 65 and older with solid tumours...
September 14, 2018: BMC Cancer
Damian J Mole, Jonathan A Fallowfield, Timothy J Kendall, Fenella Welsh, Scott I Semple, Velicia Bachtiar, Matt Kelly, Stephen J Wigmore, O James Garden, Henry R Wilman, Rajarshi Banerjee, Myrddin Rees, Michael Brady
BACKGROUND: Accurate assessment of liver health prior to undertaking resectional liver surgery or chemoembolisation for primary and secondary cancers is essential for patient safety and optimal outcomes. LiverMultiScan™, an MRI-based technology, non-invasively quantifies hepatic fibroinflammatory disease, steatosis and iron content. We hypothesise that LiverMultiScan™can quantify liver health prior to surgery and inform the risk assessment for patients considering liver surgery or chemoembolization and seek to evaluate this technology in an operational environment...
September 12, 2018: BMC Cancer
Federica Isidori, Deborah Malvi, Silvia Fittipaldi, Claudio Forcato, Isotta Bozzarelli, Claudia Sala, Giovanni Raulli, Antonia D'Errico, Michelangelo Fiorentino, Marco Seri, Kausilia K Krishnadath, Elena Bonora, Sandro Mattioli
BACKGROUND: We report on a female patient who underwent primary radical resection for a stage 2B Her-2-positive Barrett's-type esophageal adenocarcinoma (EAC). Despite Her-2 targeted therapy, her disease recurred and required repeated metastectomies. CASE PRESENTATION: Digital cell sorting and targeted sequencing of cancer sub-clones from EAC and metastases revealed a completely mutated TP53, whereas the sorted stromal cells were wild-type. Her-2 amplification was significantly lower in the metastases when the patient became therapy-resistant...
September 12, 2018: BMC Cancer
J Rotman, C H Mom, E S Jordanova, T D de Gruijl, G G Kenter
BACKGROUND: Treatment with programmed cell death receptor (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors is a promising strategy to lift tumour-induced immune response suppression. However, the current systemic treatment often causes autoimmune side effects. In more than 50% of squamous cell cervical cancer, PD-L1 expression is detected. Moreover, we observed high and interrelated rates of PD-L1 positive macrophages and regulatory T cells in metastatic lymph nodes of cervical cancer patients...
September 12, 2018: BMC Cancer
Gustavo S Fernandes, Daniel M Girardi, João Paulo G Bernardes, Felipe P Fonseca, Eduardo R Fregnani
BACKGROUND: Ameloblastoma is a slow-growing neoplasm of the jaw, for which the standard treatment is surgical removal of the lesion with high recurrence rates and elevated morbidity. Systemic therapy is not established in the literature. CASE PRESENTATION: We present a case of a 29-year-old woman diagnosed with an ameloblastoma of the left mandible who had been subjected to several surgical procedures over twenty years due to multiple local recurrences. Molecular testing revealed a BRAF V600E mutation, and vemurafenib was started...
September 12, 2018: BMC Cancer
Kristin Schink, Hans J Herrmann, Raphaela Schwappacher, Julia Meyer, Till Orlemann, Elisabeth Waldmann, Bernd Wullich, Andreas Kahlmeyer, Rainer Fietkau, Dorota Lubgan, Matthias W Beckmann, Carolin Hack, Wolfgang Kemmler, Jürgen Siebler, Markus F Neurath, Yurdagül Zopf
BACKGROUND: Physical exercise and nutritional treatment are promising measures to prevent muscle wasting that is frequently observed in advanced-stage cancer patients. However, conventional exercise is not always suitable for these patients due to physical weakness and therapeutic side effects. In this pilot study, we examined the effect of a combined approach of the novel training method whole-body electromyostimulation (WB-EMS) and individualized nutritional support on body composition with primary focus on skeletal muscle mass in advanced cancer patients under oncological treatment...
September 12, 2018: BMC Cancer
Zhenchong Xiong, Guangzheng Deng, Jin Wang, Xing Li, Xinhua Xie, Zeyu Shuang, Xi Wang
BACKGROUND: Resection of the primary tumor is recommended for symptom relief in de novo stage IV breast cancer. We explored whether local surgery could provide a survival benefit in these patients and attempted to characterize the population that could benefit from surgery. METHODS: Metastatic Breast cancer patients (N = 313) with intact primary tumor between January 2006 and April 2013 were separated into two groups according to whether or not they had undergone surgery...
September 11, 2018: BMC Cancer
Lucas C Mendez, Eugene Hsieh, Craig C Earle, Shun Wong
BACKGROUND: Sexually transmitted Human Papilloma Virus (HPV) infection is a known risk factor for cancer of the anal canal in both men and women. CASE PRESENTATION: We describe a report of synchronous carcinoma of the anal canal in a heterosexual couple. High risk type 16 HPV DNA was detected in both tumors. CONCLUSION: Longstanding sexual partners may share risk of HPV-associated anal canal cancer.
September 10, 2018: BMC Cancer
Jia Jin, Xia-Yun He
BACKGROUND: Basal cell adenocarcinomas (BCACs) arise from the minor salivary glands in the upper respiratory tract and are extremely rare. In this report, we present an unusual case of a 57-year-old male with BCAC that arose from the nasopharynx. To our knowledge, this is the first case report of nasopharyngeal BCAC. CASE PRESENTATION: In August 2010, a 57-year-old Chinese male presented with epistaxis and decreased hearing for 1 month. He was diagnosed with BCAC of the solid type that arose from the nasopharynx...
September 10, 2018: BMC Cancer
Ricarda Seidensticker, Robert Damm, Julia Enge, Max Seidensticker, Konrad Mohnike, Maciej Pech, Peter Hass, Holger Amthauer, Jens Ricke
BACKGROUND: Local ablative techniques are emerging in patients with oligometastatic disease from colorectal carcinoma, commonly described as less invasive than surgical methods. This single arm cohort seeks to determine whether such methods are suitable in patients with comorbidities or higher age. METHODS: Two hundred sixty-six patients received radiofrequency ablation (RFA), CT-guided high-dose rate brachytherapy (HDR-BT) or Y90-radioembolization (Y90-RE) during treatment of metastatic colorectal cancer (mCRC)...
September 10, 2018: BMC Cancer
Elisabetta Venturelli, Annalisa Orenti, Aline S C Fabricio, Giulia Garrone, Roberto Agresti, Biagio Paolini, Chiara Bonini, Massimo Gion, Franco Berrino, Christine Desmedt, Danila Coradini, Elia Biganzoli
Following publication of the original article [1], the authors reported that the affiliation of author Annalisa Orenti was omitted.
September 10, 2018: BMC Cancer
Wen-Yi Zhang, Xing-Xing Chen, Wen-Hao Chen, Hui Zhang, Chang-Lin Zou
BACKGROUND: The aim of this study was to develop nomograms for predicting the risk of locoregional recurrence or distant metastasis in esophageal cancer patients who were treated with esophagectomy and regional lymphadenectomy. METHODS: The clinicopathologic data of 408 esophageal cancer patients after esophagectomy and regional lymphadenectomy were analyzed in this study. Univariate and multivariate COX regression analyses were used to test the association between the clinicopathologic data and the risk of locoregional recurrence or distant metastasis...
September 10, 2018: BMC Cancer
Astrid E Slagter, Edwin P M Jansen, Hanneke W M van Laarhoven, Johanna W van Sandick, Nicole C T van Grieken, Karolina Sikorska, Annemieke Cats, Pietje Muller-Timmermans, Maarten C C M Hulshof, Henk Boot, Maartje Los, Laurens V Beerepoot, Frank P J Peters, Geke A P Hospers, Boudewijn van Etten, Henk H Hartgrink, Mark I van Berge Henegouwen, Grard A P Nieuwenhuijzen, Richard van Hillegersberg, Donald L van der Peet, Heike I Grabsch, Marcel Verheij
BACKGROUND: Although radical surgery remains the cornerstone of cure in resectable gastric cancer, survival remains poor. Current evidence-based (neo)adjuvant strategies have shown to improve outcome, including perioperative chemotherapy, postoperative chemoradiotherapy and postoperative chemotherapy. However, these regimens suffer from poor patient compliance, particularly in the postoperative phase of treatment. The CRITICS-II trial aims to optimize preoperative treatment by comparing three treatment regimens: (1) chemotherapy, (2) chemotherapy followed by chemoradiotherapy and (3) chemoradiotherapy...
September 10, 2018: BMC Cancer
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