Fabrizio Vecchio, Claudio Babiloni, Roberta Lizio, Fabrizio De Vico Fallani, Katarzyna Blinowska, Giulio Verrienti, Giovanni Frisoni, Paolo M Rossini
The human brain contains an intricate network of about 100 billion neurons. Aging of the brain is characterized by a combination of synaptic pruning, loss of cortico-cortical connections, and neuronal apoptosis that provoke an age-dependent decline of cognitive functions. Neural/synaptic redundancy and plastic remodeling of brain networking, also secondary to mental and physical training, promote maintenance of brain activity and cognitive status in healthy elderly subjects for everyday life. However, age is the main risk factor for neurodegenerative disorders such as Alzheimer's disease (AD) that impact on cognition...
2013: Supplements to Clinical Neurophysiology