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BMC Neuroscience

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https://www.readbyqxmd.com/read/28086802/brain-metabolic-pattern-analysis-using-a-magnetic-resonance-spectra-classification-software-in-experimental-stroke
#1
Elena Jiménez-Xarrié, Myriam Davila, Ana Paula Candiota, Raquel Delgado-Mederos, Sandra Ortega-Martorell, Margarida Julià-Sapé, Carles Arús, Joan Martí-Fàbregas
BACKGROUND: Magnetic resonance spectroscopy (MRS) provides non-invasive information about the metabolic pattern of the brain parenchyma in vivo. The SpectraClassifier software performs MRS pattern-recognition by determining the spectral features (metabolites) which can be used objectively to classify spectra. Our aim was to develop an Infarct Evolution Classifier and a Brain Regions Classifier in a rat model of focal ischemic stroke using SpectraClassifier. RESULTS: A total of 164 single-voxel proton spectra obtained with a 7 Tesla magnet at an echo time of 12 ms from non-infarcted parenchyma, subventricular zones and infarcted parenchyma were analyzed with SpectraClassifier ( http://gabrmn...
January 13, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28081713/genistein-protects-against-a%C3%AE-25-35-induced-apoptosis-of-pc12-cells-through-jnk-signaling-and-modulation-of-bcl-2-family-messengers
#2
Fuling You, Qiao Li, Guifang Jin, Yaojie Zheng, Jingrong Chen, Hong Yang
BACKGROUND: Deposition of aggregated amyloid beta (Aβ) protein is hallmark of Alzheimer's disease, leading to dysfunction and apoptosis of neurons. The isoflavone phytoestrogen compound genistein (Gen) exerts a significant protective effect against Aβ25-35 induced neurotoxicity and mitochondrial damage in rat pheochromocytoma (PC12) cells. However, the mechanisms underlying Gen's rescue remain elusive. Therefore we endeavored to research further the molecular mechanisms underlying Gen's inhibition of Aβ25-35 induced apoptosis of neurons...
January 12, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28061814/cx3c-chemokine-receptor-1-deficiency-modulates-microglia-morphology-but-does-not-affect-lesion-size-and-short-term-deficits-after-experimental-stroke
#3
Gerlinde van der Maten, Vivien Henck, Tadeusz Wieloch, Karsten Ruscher
BACKGROUND: The fractalkine/CX3C chemokine receptor 1 (CX3CR1) pathway has been identified to play an essential role in the chemotaxis of microglia, leukocyte trafficking and microglia/macrophage recruitment. It has also been shown to be important in the regulation of the inflammatory response in the early phase after experimental stroke. The present study was performed to investigate if CX3CR1 deficiency affects microglia during the first 14 days with consequences for tissue damage after experimental stroke...
January 6, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28056817/proteomic-analyses-of-limbic-regions-in-neonatal-male-female-and-androgen-receptor-knockout-mice
#4
Anna Zettergren, Sara Karlsson, Erik Studer, Anna Sarvimäki, Petronella Kettunen, Annika Thorsell, Carina Sihlbom, Lars Westberg
BACKGROUND: It is well-established that organizational effects of sex steroids during early development are fundamental for sex-typical displays of, for example, mating and aggressive behaviors in rodents and other species. Male and female brains are known to differ with respect to neuronal morphology in particular regions of the brain, including the number and size of neurons, and the density and length of dendrites in nuclei of hypothalamus and amygdala. The aim of the present study was to use global proteomics to identify proteins differentially expressed in hypothalamus/amygdala during early development (postnatal day 8) of male, female and conditional androgen receptor knockout (AR(NesDel)) male mice, lacking androgen receptors specifically in the brain...
January 5, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28056813/hemodynamic-effects-of-intraoperative-anesthetics-administration-in-photothrombotic-stroke-model-a-study-using-laser-speckle-imaging
#5
Hongyang Lu, Yao Li, Bin Bo, Lu Yuan, Xiaodan Lu, Hangdao Li, Shanbao Tong
BACKGROUND: Previous neuroimaging studies have shown the hemodynamic effect of either preconditioning or postconditioning anesthesia in ischemic stroke model. However, the anesthetic effect in hemodynamics during and immediately after the stroke modeling surgery remains unknown due to the lack of appropriate anesthesia-free stroke model and intraoperative imaging technology. In the present study, we utilized our recently developed photothrombotic model of focal cerebral ischemia in conscious and freely moving rats, and investigated transient hemodynamic changes with or without isoflurane administration...
January 5, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28056806/suppression-of-experimental-autoimmune-encephalomyelitis-by-ultraviolet-light-is-not-mediated-by-isomerization-of-urocanic-acid
#6
Amy A Irving, Steven J Marling, Lori A Plum, Hector F DeLuca
BACKGROUND: Ultraviolet B irradiation confers strong resistance against experimental autoimmune encephalomyelitis, a model of multiple sclerosis. This protection by ultraviolet B is independent of vitamin D production but causes isomerization of urocanic acid, a naturally occurring immunosuppressant. METHODS: To determine whether UCA isomerization from trans to cis is responsible for the protection against experimental autoimmune encephalomyelitis afforded by ultraviolet B, trans- or cis-urocanic acid was administered to animals and their disease progression was monitored...
January 5, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28056790/immunization-with-neural-derived-peptides-plus-scar-removal-induces-a-permissive-microenvironment-and-improves-locomotor-recovery-after-chronic-spinal-cord-injury
#7
Roxana Rodríguez-Barrera, Adrián Flores-Romero, Ana María Fernández-Presas, Elisa García-Vences, Raúl Silva-García, Mina Konigsberg, Liliana Blancas-Espinoza, Vinnitsa Buzoianu-Anguiano, Karla Soria-Zavala, Paola Suárez-Meade, Antonio Ibarra
BACKGROUND: Immunization with neural derived peptides (INDP) as well as scar removal-separately-have shown to induce morphological and functional improvement after spinal cord injury (SCI). In the present study, we compared the effect of INDP alone versus INDP with scar removal on motor recovery, regeneration-associated and cytokine gene expression, and axonal regeneration after chronic SCI. Scar removal was conducted through a single incision with a double-bladed scalpel along the stump, and scar renewal was halted by adding α,α'-dipyridyl...
January 5, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28049513/neural-hyperactivity-in-the-amygdala-induced-by-chronic-treatment-of-rats-with-analgesics-may-elucidate-the-mechanisms-underlying-psychiatric-comorbidities-associated-with-medication-overuse-headache
#8
Aree Wanasuntronwong, Ukkrit Jansri, Anan Srikiatkhachorn
BACKGROUND: Patients with medication-overuse headache suffer not only from chronic headache, but often from psychiatric comorbidities, such as anxiety and depression. The mechanisms underlying these comorbidities are unclear, but the amygdala is likely to be involved in their pathogenesis. To investigate the mechanisms underlying the comorbidities we used elevated plus maze and open field tests to assess anxiety-like behavior in rats chronically treated with analgesics. We measured the electrical properties of neurons in the amygdala, and examined the cortical spreading depression (CSD)-evoked expression of Fos in the trigeminal nucleus caudalis (TNC) and amygdala of rats chronically treated with analgesics...
January 3, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28049450/yawning-reduces-facial-temperature-in-the-high-yawning-subline-of-sprague-dawley-rats
#9
Jose R Eguibar, Carlos A Uribe, Carmen Cortes, Amando Bautista, Andrew C Gallup
BACKGROUND: Yawning is a stereotyped behavior that enhances blood flow to the skull, and the resulting counterflow has been hypothesized as a mechanism for brain cooling. Studies have shown that yawns are strongly associated with physiological and pathological conditions that increase brain temperature, and that they are followed by equivalent decreases in brain temperature. However, measured reductions in cranial or facial temperatures following yawning have yet to be reported, to our knowledge...
January 3, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28049445/expertise-related-functional-brain-network-efficiency-in-healthy-older-adults
#10
Julia C Binder, Ladina Bezzola, Aurea I S Haueter, Carina Klein, Jürg Kühnis, Hansruedi Baetschmann, Lutz Jäncke
BACKGROUND: In view of age-related brain changes, identifying factors that are associated with healthy aging are of great interest. In the present study, we compared the functional brain network characteristics of three groups of healthy older participants aged 61-75 years who had a different cognitive and motor training history (multi-domain group: participants who had participated in a multi-domain training; visuomotor group: participants who had participated in a visuomotor training; control group: participants with no specific training history)...
January 3, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28049438/important-modifications-by-sugammadex-a-modified-%C3%AE-cyclodextrin-of-ion-currents-in-differentiated-nsc-34-neuronal-cells
#11
Hung-Te Hsu, Yi-Ching Lo, Yan-Ming Huang, Yu-Ting Tseng, Sheng-Nan Wu
BACKGROUND: Sugammadex (SGX) is a modified γ-cyclodextrin used for reversal of steroidal neuromuscular blocking agents during general anesthesia. Despite its application in clinical use, whether SGX treatment exerts any effects on membrane ion currents in neurons remains largely unclear. In this study, effects of SGX treatment on ion currents, particularly on delayed-rectifier K(+) current [I K(DR)], were extensively investigated in differentiated NSC-34 neuronal cells. RESULTS: After cells were exposed to SGX (30 μM), there was a reduction in the amplitude of I K(DR) followed by an apparent slowing in current activation in response to membrane depolarization...
January 3, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28049434/why-does-a-cooled-object-feel-heavier-psychophysical-investigations-into-the-weber-s-phenomenon
#12
James S Dunn, David A Mahns, Saad S Nagi
BACKGROUND: It has long been known that a concomitantly cooled stimulus is perceived as heavier than the same object at a neutral temperature-termed Weber's Phenomenon (WP). In the current study, we re-examined this phenomenon using well-controlled force and temperature stimuli to explore the complex interplay between thermal and tactile systems, and the peripheral substrates contributing to these interactions. A feedback-controlled apparatus was constructed using a mechanical stimulator attached to a 5- × 5-mm thermode...
January 3, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28049425/the-variability-of-motor-evoked-potential-latencies-in-neurosurgical-motor-mapping-by-preoperative-navigated-transcranial-magnetic-stimulation
#13
Nico Sollmann, Lucia Bulubas, Noriko Tanigawa, Claus Zimmer, Bernhard Meyer, Sandro M Krieg
BACKGROUND: Recording of motor evoked potentials (MEPs) is used during navigated transcranial magnetic stimulation (nTMS) motor mapping to locate motor function in the human brain. However, factors potentially underlying MEP latency variability in neurosurgical motor mapping are vastly unknown. In the context of this study, one hundred brain tumor patients underwent preoperative nTMS-based motor mapping of the tumor hemisphere between 2010 and 2013. Fourteen predefined predictor variables were recorded, and MEP latencies of abductor pollicis brevis muscle (APB), abductor digiti minimi muscle (ADM), and flexor carpi radialis muscle (FCR) were analyzed using linear mixed-effect multiple regression analysis with the forward step-wise model comparison approach...
January 3, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/27955617/planar-cell-polarity-genes-frizzled3a-vangl2-and-scribble-are-required-for-spinal-commissural-axon-guidance
#14
Simon D Sun, Ashley M Purdy, Gregory S Walsh
BACKGROUND: A fundamental feature of early nervous system development is the guidance of axonal projections to their targets in order to assemble neural circuits that control behavior. Spinal commissural neurons are an attractive model to investigate the multiple guidance cues that control growth cone navigation both pre- and post-midline crossing, as well as along both the dorsal-ventral (D-V) and anterior-posterior (A-P) axes. Accumulating evidence suggests that guidance of spinal commissural axons along the A-P axis is dependent on components of the planar cell polarity (PCP) signaling pathway...
December 12, 2016: BMC Neuroscience
https://www.readbyqxmd.com/read/27927188/investigating-potentially-salvageable-penumbra-tissue-in-an-in-vivo-model-of-transient-ischemic-stroke-using-sodium-diffusion-and-perfusion-magnetic-resonance-imaging
#15
Friedrich Wetterling, Eva Chatzikonstantinou, Laurent Tritschler, Stephen Meairs, Marc Fatar, Lothar R Schad, Saema Ansar
BACKGROUND: Diffusion magnetic resonance imaging (MRI) is the current-state-of-the-art technique to clinically investigate acute (0-24 h) ischemic stroke tissue. However, reduced apparent diffusion coefficient (ADC)-considered a marker of tissue damage-was observed to reverse spontaneously during the subacute stroke phase (24-72 h) which means that low ADC cannot be used to reflect the damaged tissue after 24 h in experimental and clinical studies. One reason for the change in ADC is that ADC values drop with cytotoxic edema (acute phase) and rise when vasogenic edema begins (subacute phase)...
December 7, 2016: BMC Neuroscience
https://www.readbyqxmd.com/read/27919226/molar-loss-and-powder-diet-leads-to-memory-deficit-and-modifies-the-mrna-expression-of-brain-derived-neurotrophic-factor-in-the-hippocampus-of-adult-mice
#16
Yosuke Takeda, Hiroshi Oue, Shinsuke Okada, Akira Kawano, Katsunori Koretake, Makoto Michikawa, Yasumasa Akagawa, Kazuhiro Tsuga
BACKGROUND: It is known that tooth loss is known to be a risk factor for Alzheimer's disease and soft diet feeding induces memory impairment. Recent studies have shown that brain-derived neurotrophic factor (BDNF) is associated with tooth loss or soft diet in young animal model, and that BDNF expression is decreased in patients with Alzheimer's disease. However, single or combined effect of tooth loss and/or soft diet on brain function has not fully understood. Here we examined the effect of molar loss and powder diet on memory ability and the expression of BDNF mRNA in the hippocampus of adult C57BL/6J mice...
December 5, 2016: BMC Neuroscience
https://www.readbyqxmd.com/read/27905881/bone-morphogenetic-protein-2-mediated-pain-and-inflammation-in-a-rat-model-of-posterolateral-arthrodesis
#17
Kendall Mitchell, Jill P Shah, Clifton L Dalgard, Lyubov V Tsytsikova, Ashley C Tipton, Anton E Dmitriev, Aviva J Symes
BACKGROUND: Bone morphogenetic protein-2 (BMP-2) is a pleiotropic, secreted molecule with diverse effects. The potent ability of BMP-2 to stimulate bone growth prompted its widespread clinical use for arthrodesis (spine fusion). However, elevated post-operative pain in patients treated with BMP-2 has been increasingly reported. Determining whether BMP-2 induces pain directly or whether it induces neuroinflammation, which could lower the threshold for pain, is important for developing therapeutic interventions...
December 1, 2016: BMC Neuroscience
https://www.readbyqxmd.com/read/27903258/catwalk-gait-analysis-in-a-rat-model-of-multiple-sclerosis
#18
Sabine Herold, Prateek Kumar, Klaus Jung, Irina Graf, Henrike Menkhoff, Xenia Schulz, Mathias Bähr, Katharina Hein
BACKGROUND: Myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) is a widely used animal model for multiple sclerosis. The characteristic feature of the MOG-EAE model in Brown Norway rats is consistent involvement of the spinal cord resulting in limb paresis. The aim of the study was to investigate whether early subclinical gait abnormalities are present in this animal model and can be detected by CatWalk XT, a fully automated gait analysis system...
November 30, 2016: BMC Neuroscience
https://www.readbyqxmd.com/read/27903255/epigenetic-evidence-for-involvement-of-the-oxytocin-receptor-gene-in-obsessive-compulsive-disorder
#19
Carolina Cappi, Juliana Belo Diniz, Guaraci L Requena, Tiaya Lourenço, Bianca Cristina Garcia Lisboa, Marcelo Camargo Batistuzzo, Andrea H Marques, Marcelo Q Hoexter, Carlos A Pereira, Euripedes Constantino Miguel, Helena Brentani
BACKGROUND: Obsessive-compulsive disorder (OCD) is a chronic neurodevelopmental disorder that affects up to 3% of the general population. Although epigenetic mechanisms play a role in neurodevelopment disorders, epigenetic pathways associated with OCD have rarely been investigated. Oxytocin is a neuropeptide involved in neurobehavioral functions. Oxytocin has been shown to be associated with the regulation of complex socio-cognitive processes such as attachment, social exploration, and social recognition, as well as anxiety and other stress-related behaviors...
November 30, 2016: BMC Neuroscience
https://www.readbyqxmd.com/read/27903237/leucine-rich-repeat-kinase-2-lrrk2-regulates-%C3%AE-synuclein-clearance-in-microglia
#20
Tatsunori Maekawa, Toshikuni Sasaoka, Sadahiro Azuma, Takafumi Ichikawa, Heather L Melrose, Matthew J Farrer, Fumiya Obata
BACKGROUND: α-Synuclein (αSYN) has been genetically implicated in familial and sporadic Parkinson's disease (PD), and is associated with disease susceptibility, progression and pathology. Excess amounts of αSYN are toxic to neurons. In the brain, microglial αSYN clearance is closely related to neuronal survival. Leucine-rich repeat kinase 2 (LRRK2) is the one of the other genes implicated in familial and sporadic PD. While LRRK2 is known to be expressed in microglia, its true function remains to be elucidated...
November 30, 2016: BMC Neuroscience
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