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BMC Neuroscience

Yi Yuan, Xingran Wang, Jiaqing Yan, Xiaoli Li
BACKGROUND: Low-intensity pulsed ultrasound stimulation (LIPUS) has been proven to be a noninvasive method with high spatial resolution and deep penetration. Previous studies have qualitatively demonstrated that the electromyographic response caused by LIPUS in the mouse motor cortex is affected by the anesthetic state of the mice. However, the quantitative relationship between motor response and anesthetic dose remains unclear. RESULTS: Experimental results show that the success rate decreases stepwise as the isoflurane concentration/mouse weight ratio increases (ratios: [0...
December 3, 2018: BMC Neuroscience
Varun Kumar, Yi-Chinn Weng, Yu-Chieh Wu, Yu-Ting Huang, Wen-Hai Chou
BACKGROUND: Global cerebral ischemia triggers neurodegeneration in the hippocampal CA1 region, but the mechanism of neuronal death remains elusive. The epsilon isoform of protein kinase C (PKCε) has recently been identified as a master switch that controls the nucleocytoplasmic trafficking of ATF2 and the survival of melanoma cells. It is of interest to assess the role of PKCε-ATF2 signaling in neurodegeneration. RESULTS: Phosphorylation of ATF2 at Thr-52 was reduced in the hippocampus of PKCε null mice, suggesting that ATF2 is a phosphorylation substrate of PKCε...
November 29, 2018: BMC Neuroscience
Sakari Leino, Samuel Kohtala, Tomi Rantamäki, Sini K Koski, Saara Rannanpää, Outi Salminen
BACKGROUND: The treatment of Parkinson's disease is often complicated by levodopa-induced dyskinesia (LID). Nicotinic acetylcholine receptor agonists can alleviate LID in animal models but may be less effective in conditions of severe dopaminergic denervation. While the mechanisms of LID remain incompletely understood, elevated corticostriatal levels of the brain-derived neurotrophic factor (BDNF) have been suggested to play a role. Here, female mice with near-total unilateral 6-hydroxydopamine-induced nigrostriatal lesions were chronically treated with levodopa, and the effects of the α7 nicotinic receptor partial agonist AZD0328 and nicotine on LID were assessed...
November 29, 2018: BMC Neuroscience
Wenbo Wu, Siyi Xu, Jialin Wang, Kuiming Zhang, Mingkun Zhang, Yang Cao, Hongqing Ren, Deyou Zheng, Chunlong Zhong
BACKGROUND: Traumatic brain injury (TBI) is a complex condition and remains a prominent public and medical health issue in individuals of all ages. A rapid increase in extracellular glutamate occurs after TBI, leading to glutamate-induced excitotoxicity, which causes neuronal damage and further functional impairments. Although inhibition of glutamate carboxypeptidase II (GCP II) is considered a potential approach for reducing glutamate-induced excitotoxicity after TBI, further detailed evidence regarding its efficacy is required...
November 20, 2018: BMC Neuroscience
Sidra Khalid, Muhammad Ammar Zahid, Hussain Ali, Yeong S Kim, Salman Khan
BACKGROUND: Alzheimer's disease (AD) is a primary cause of dementia in ageing population affecting more than 35 million people around the globe. It is a chronic neurodegenerative disease caused by defected folding and aggregation of amyloid beta (Aβ) protein. Aβ is formed by the cleavage of membrane embedded amyloid precursor protein (APP) by using enzyme 'transmembrane aspartyl protease, β-secretase'. Inhibition of β-secretase is a viable strategy to prevent neurotoxicity in AD. Another strategy in the treatment of AD is inhibition of acetylcholinesterase...
November 13, 2018: BMC Neuroscience
(no author information available yet)
No abstract text is available yet for this article.
November 13, 2018: BMC Neuroscience
Dmitry A Sibarov, Ekaterina E Poguzhelskaya, Sergei M Antonov
BACKGROUND: The plasma membrane Na+ /Ca2+ -exchanger (NCX) has recently been shown to regulate Ca2+ -dependent N-methyl-D-aspartate receptor (NMDAR) desensitization, suggesting a tight interaction of NCXs and NMDARs in lipid nanoclasters or "rafts". To evaluate possible role of this interaction we studied effects of Li+ on NMDA-elicited whole-cell currents and Ca2+ responses of rat cortical neurons in vitro before and after cholesterol extraction by methyl-β-cyclodextrin (MβCD)...
November 12, 2018: BMC Neuroscience
Armando Valenzuela Peraza, David Calderón Guzmán, Norma Osnaya Brizuela, Maribel Ortiz Herrera, Hugo Juárez Olguín, Miroslava Lindoro Silva, Belén Juárez Tapia, Gerardo Barragán Mejía
BACKGROUND: Neurological disorders suggest that the excitotoxicity involves a drastic increase in intracellular Ca2+ concentrations and the formation of reactive oxygen species. The presence of these free radicals may also affect the dopaminergic system. The aim of this work was to determine if riboflavin (B2 ) and pyridoxine (B6 ) provide protection to the brain against free radicals generated by 3-nitropropionic acid (3-NPA) by measuring the levels of dopamine (DA) and selected oxidative stress markers...
November 9, 2018: BMC Neuroscience
Hung-Chen Wang, Kuang-I Cheng, Pei-Ru Chen, Kuang-Yi Tseng, Aij-Lie Kwan, Lin-Li Chang
BACKGROUND: Glycine receptors (GlyRs) are involved in the development of spinal pain sensitization. The GlyRα3 subunit has recently emerged as a key factor in inflammatory pain pathways in the spinal cord dorsal horn (DH). Our study is to identify the extent of location and cell types expressing different GlyR subunits in spinal cord and dorsal root ganglion (DRGs). To tease out the possible actions of GlyRs on pain transmission, we investigate the effects produced by GlyRs on acute inflammatory pain by behavioral testing using prostaglandin E2 (PGE2) intrathecal injection models...
November 9, 2018: BMC Neuroscience
Adriana Schatton, Julia Agoro, Janis Mardink, Gérard Leboulle, Constance Scharff
BACKGROUND: FoxP transcription factors play crucial roles for the development and function of vertebrate brains. In humans the neurally expressed FOXPs, FOXP1, FOXP2, and FOXP4 are implicated in cognition, including language. Neural FoxP expression is specific to particular brain regions but FoxP1, FoxP2 and FoxP4 are not limited to a particular neuron or neurotransmitter type. Motor- or sensory activity can regulate FoxP2 expression, e.g. in the striatal nucleus Area X of songbirds and in the auditory thalamus of mice...
November 6, 2018: BMC Neuroscience
Julia Adelöf, My Andersson, Michelle Porritt, Anne Petersen, Madeleine Zetterberg, John Wiseman, Malin Hernebring
BACKGROUND: The proteasome system plays an important role in synaptic plasticity. Induction and maintenance of long term potentiation is directly dependent on selective targeting of proteins for proteasomal degradation. The 20S proteasome activator PA28αβ activates hydrolysis of small nonubiquitinated peptides and possesses protective functions upon oxidative stress and proteinopathy. The effect of PA28αβ activity on behavior and memory function is, however, not known. We generated a mouse model that overexpresses PA28α (PA28αOE) to understand PA28αβ function during healthy adult homeostasis via assessment of physiological and behavioral profiles, focusing on female mice...
November 6, 2018: BMC Neuroscience
Morten B Schou, Sverre Georg Sæther, Ole Kristian Drange, Karoline Krane-Gartiser, Solveig K Reitan, Arne E Vaaler, Daniel Kondziella
BACKGROUND: The clinical significance of anti-neuronal antibodies in patients with psychiatric disorders, but without encephalitis, remains unknown. In patients admitted to acute psychiatric inpatient care we aimed to identify clinical features distinguishing anti-neuronal antibody positive patients from matched controls. RESULTS: Patients who were serum-positive to N-methyl D-aspartate receptor (NMDAR) (n = 21), contactin-associated protein 2 (CASPR2) (n = 14) and/or glutamic acid decarboxylase 65 (GAD65) (n = 9) antibodies (cases) were age and sex matched (1:2) with serum-negative patients from the same cohort (controls)...
November 3, 2018: BMC Neuroscience
(no author information available yet)
No abstract text is available yet for this article.
October 29, 2018: BMC Neuroscience
(no author information available yet)
No abstract text is available yet for this article.
October 29, 2018: BMC Neuroscience
Tifei Yuan, Ali Yadollahpour, Julio Salgado-Ramírez, Daniel Robles-Camarillo, Rocío Ortega-Palacios
BACKGROUND: Tinnitus is the perception of sound in the absence of any external acoustic stimulation. Transcranial direct current stimulation (tDCS) has shown promising though heterogeneous therapeutic outcomes for tinnitus. The present study aims to review the recent advances in applications of tDCS for tinnitus treatment. In addition, the clinical efficacy and main mechanisms of action of tDCS on suppressing tinnitus are discussed. METHODS: The study was performed in accordance with the PRISMA guidelines...
October 25, 2018: BMC Neuroscience
Michela Balconi, Maria Elide Vanutelli
BACKGROUND: Social behavior and interactions pervasively shape and influence our lives and relationships. Competition, in particular, has become a core topic in social neuroscience since it stresses the relevance and salience of social comparison processes between the inter-agents that are involved in a common task. The majority of studies, however, investigated such kind of social interaction via one-person individual paradigms, thus not taking into account relevant information concerning interdependent participants' behavioral and neural responses...
October 18, 2018: BMC Neuroscience
Osman Shabir, Jason Berwick, Sheila E Francis
Efficient blood supply to the brain is of paramount importance to its normal functioning and improper blood flow can result in potentially devastating neurological consequences. Cerebral blood flow in response to neural activity is intrinsically regulated by a complex interplay between various cell types within the brain in a relationship termed neurovascular coupling. The breakdown of neurovascular coupling is evident across a wide variety of both neurological and psychiatric disorders including Alzheimer's disease...
October 17, 2018: BMC Neuroscience
Sheng Wei, Zifa Li, Meng Ren, Jieqiong Wang, Jie Gao, Yinghui Guo, Kaiyong Xu, Fang Li, Dehao Zhu, Hao Zhang, Rongju Lv, Mingqi Qiao
BACKGROUND: Epidemiological surveys and studies with animal models have established a relationship between maternal stress and affective disorders in their offspring. However, whether maternal depression before pregnancy influences behaviour and related neurobiological mechanisms in the offspring has not been studied. RESULTS: A social defeat stress (SDS) maternal rat model was established using the resident-intruder paradigm with female specific pathogen-free Wistar rats and evaluated with behavioural tests...
October 16, 2018: BMC Neuroscience
Ping Xie, Sa Zhou, Xingran Wang, Yibo Wang, Yi Yuan
BACKGROUND: Pulsed transcranial ultrasound stimulation (pTUS) can modulate the neuronal activity of motor cortex and elicit muscle contractions. Cortico-muscular coupling (CMC) can serve as a tool to identify interaction between the oscillatory activity of the motor cortex and effector muscle. This research aims to explore the neuromodulatory effect of low-intensity, pTUS with different number of tone burst to neural circuit of motor-control system by analyzing the coupling relationship between motor cortex and tail muscle in mouse...
October 3, 2018: BMC Neuroscience
Noushin Nikray, Isaac Karimi, Zahraminoosh Siavashhaghighi, Lora A Becker, Mohammad Mehdi Mofatteh
BACKGROUND: Environmental uncertainty, such as food deprivation, may alter internal milieu of nervous system through various mechanisms. In combination with circumstances of stress or aging, high consumption of unsaturated fatty acids and oxygen can make neural tissues sensitive to oxidative stress (OS). For adult rats, diminished level of gonadal steroid hormones accelerates OS and may result in special behavioral manifestations. This study was aimed to partially answer the question whether OS mediates trade-off between food hoarding and food intake (fat hoarding) in environmental uncertainty (e...
September 24, 2018: BMC Neuroscience
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