Changyu Huang, Yang Chen, Yuanqing Cai, Haiqi Ding, Jiaoying Hong, Shan You, Yiming Lin, Hongxin Hu, Yongfa Chen, Xueni Hu, Yanshu Chen, Ying Huang, Chaofan Zhang, Yunzhi Lin, Zida Huang, Wenbo Li, Wenming Zhang, Xinyu Fang
BACKGROUND: The interaction between the nervous system and the immune system can affect the outcome of a bacterial infection. Staphylococcus aureus skin infection is a common infectious disease, and elucidating the relationship between the nervous system and immune system may help to improve treatment strategies. RESULTS: In this study, we found that the local release of calcitonin gene-related peptide (CGRP) increased during S. aureus skin infection, and S. aureus could promote the release of CGRP from transient receptor potential cation channel subfamily V member 1 (TRPV1+ ) neurons in vitro...
December 21, 2023: BMC Immunology