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BMC Immunology

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https://www.readbyqxmd.com/read/30075754/pharmacologically-upregulated-carcinoembryonic-antigen-expression-enhances-the-cytolytic-activity-of-genetically-modified-chimeric-antigen-receptor-nk-92mi-against-colorectal-cancer-cells
#1
Masayuki Shiozawa, Chuan-Hsin Chang, Yi-Chun Huang, Yi-Ching Chen, Mau-Shin Chi, Hsu-Chao Hao, Yue-Cune Chang, Satoru Takeda, Kwan-Hwa Chi, Yu-Shan Wang
BACKGROUND: The natural killer cell line, NK-92MI, is cytotoxic against various types of cancer. The aim of this study was to develop chimeric antigen receptor-modified (CAR) NK-92MI cells targeting carcinoembryonic antigen-expressing (CEA) tumours and increase killing efficacy by pharmacologically modifying CEA-expression. RESULT: We generated anti-CEA-CAR NK-92MI cells by retroviral vector transduction. This genetically-modified cell line recognised and lysed high CEA-expressing tumour cell lines (LS174T) at 47...
August 3, 2018: BMC Immunology
https://www.readbyqxmd.com/read/30055570/mir-18a-and-mir-17-are-positively-correlated-with-circulating-pd-1-icos-follicular-helper-t-cells-after-hepatitis-b-vaccination-in-a-chinese-population
#2
Xiaojia Xu, Yulian Li, Yaping Liang, Mingjuan Yin, Zuwei Yu, Yan Zhang, Lingfeng Huang, Jindong Ni
BACKGROUND: While vaccination remains the most effective method to control hepatitis B virus (HBV) infection, 5-10% of recipients exhibit non-responsiveness to the HB vaccine. Immunological analysis of strong, weak or absent protective antibody responses to the HB vaccine should provide insights into the mechanisms that contribute to non-responsiveness. RESULTS: We investigated the potential involvement of follicular helper T (Tfh) cells in the immune response to HB vaccine, and associations between the miR-17-92 cluster and Tfh cells...
July 28, 2018: BMC Immunology
https://www.readbyqxmd.com/read/30055563/the-differences-in-immunoadjuvant-mechanisms-of-tlr3-and-tlr4-agonists-on-the-level-of-antigen-presenting-cells-during-immunization-with-recombinant-adenovirus-vector
#3
Ekaterina Lebedeva, Alexander Bagaev, Alexey Pichugin, Marina Chulkina, Andrei Lysenko, Irina Tutykhina, Maxim Shmarov, Denis Logunov, Boris Naroditsky, Ravshan Ataullakhanov
BACKGROUND: Agonists of TLR3 and TLR4 are effective immunoadjuvants for different types of vaccines. The mechanisms of their immunostimulatory action differ significantly; these differences are particularly critical for immunization with non-replicating adenovirus vectors (rAds) based vaccines. Unlike traditional vaccines, rAd based vaccines are not designed to capture vaccine antigens from the external environment by antigen presenting cells (APCs), but rather they are targeted to the de novo synthesis of vaccine antigens in APCs transfected with rAd...
July 28, 2018: BMC Immunology
https://www.readbyqxmd.com/read/29996768/sustained-high-glucose-exposure-sensitizes-macrophage-responses-to-cytokine-stimuli-but-reduces-their-phagocytic-activity
#4
Sofia Pavlou, Jaime Lindsay, Rebecca Ingram, Heping Xu, Mei Chen
BACKGROUND: Macrophages are tissue resident immune cells important for host defence and homeostasis. During diabetes, macrophages and other innate immune cells are known to have a pro-inflammatory phenotype, which is believed to contribute to the pathogenesis of various diabetic complications. However, diabetic patients are highly susceptible to bacterial infections, and often have impaired wound healing. The molecular mechanism underlying the paradox of macrophage function in diabetes is not fully understood...
July 11, 2018: BMC Immunology
https://www.readbyqxmd.com/read/29986661/dynamics-of-macrophage-populations-of-the-liver-after-subtotal-hepatectomy-in-rats
#5
Andrey V Elchaninov, Timur Kh Fatkhudinov, Natalia Y Usman, Evgeniya Y Kananykhina, Irina V Arutyunyan, Andrey V Makarov, Anastasia V Lokhonina, Irina Z Eremina, Viktor V Surovtsev, Dmitry V Goldshtein, Galina B Bolshakova, Valeria V Glinkina, Gennady T Sukhikh
BACKGROUND: In many clinical cases of extensive liver resection (e.g. due to malignancy), the residual portion is too small to maintain the body homeostasis. The resulting acute liver failure is associated with the compensatory growth inhibition, which is a typical manifestation of the 'small for size' liver syndrome. The study investigates possible causes of the delayed onset of hepatocyte proliferation after subtotal hepatectomy (80% liver resection) in rats. RESULTS: The data indicate that the growth inhibition correlates with delayed upregulation of the Tnf gene expression and low content of the corresponding Tnfα protein within the residual hepatic tissue...
July 9, 2018: BMC Immunology
https://www.readbyqxmd.com/read/29945547/analysis-of-differences-between-total-igg-and-sum-of-the-igg-subclasses-in-children-with-suspected-immunodeficiency-indication-of-determinants
#6
Gerard Pasternak, Aleksandra Lewandowicz-Uszyńska, Katarzyna Pentoś
BACKGROUND: Deficits in disorders of humoral immunity associated with a deficit of antibodies are the most common primary immunodeficiency. Total IgG and IgG subclasses measurements are used to diagnose, differentiate and control in patients with primary and secondary immunodeficiencies. METHODS: The purpose of the study was to analyze the structure patients group according to difference between total IgG and sum of the IgG subclasses and to determine factors affecting the level of this difference...
June 27, 2018: BMC Immunology
https://www.readbyqxmd.com/read/29940852/mcsf-drives-regulatory-dc-development-in-stromal-co-cultures-supporting-hematopoiesis
#7
Sawang Petvises, Pravin Periasamy, Helen C O'Neill
BACKGROUND: Splenic stroma overlaid with hematopoietic progenitors supports in vitro hematopoiesis with production of dendritic-like cells. Co-cultures of murine lineage-depleted bone marrow over the 5G3 stromal line produce two populations of cells, characterised as CD11b+ CD11c+ MHC-II- dendritic-like 'L-DC', and CD11b+ CD11c+ MHC-II+ cells, resembling conventional dendritic cells (cDC). To date, the functional capacity of these two subsets has not been clearly distinguished. RESULTS: Here we show both the L-DC and cDC-like subsets can be activated and induce proliferation of OT-I CD8+ T cells, being strong inducers of IL-2 and IFN-γ production...
June 26, 2018: BMC Immunology
https://www.readbyqxmd.com/read/29940856/interference-with-kctd9-inhibits-nk-cell-activation-and-ameliorates-fulminant-liver-failure-in-mice
#8
Xiaoping Zhang, Lin Zhu, Yaoyong Zhou, Aichao Shi, Hongwu Wang, Meifang Han, Xiaoyang Wan, Semvua Bukheti Kilonzo, Xiaoping Luo, Tao Chen, Qin Ning
BACKGROUND: Potassium channel tetramerisation domain containing 9 (KCTD9), a member of KCTD family with a DNA-like pentapeptide repeat domain, was found to be increased particularly in NK cells of patients with HBV-induced acute-on-chronic liver failure (HBV-ACLF) and experimental viral fulminant hepatitis. Knockdown of KCTD9 in immortalized NK cells inhibits cytokines production and cytotoxicity. As NK cell activation was shown to exacerbate liver damage in viral fulminant hepatitis, we propose that target inhibition of KCTD9 may prohibit NK cells activity and thus ameliorate liver damage in viral fulminant hepatitis...
June 25, 2018: BMC Immunology
https://www.readbyqxmd.com/read/29940854/rapid-loss-of-early-antigen-presenting-activity-of-lymph-node-dendritic-cells-against-ag85a-protein-following-mycobacterium-bovis-bcg-infection
#9
Zhengzhong Xu, Aihong Xia, Xin Li, Zhaocheng Zhu, Yechi Shen, Shanshan Jin, Tian Lan, Yuqing Xie, Han Wu, Chuang Meng, Lin Sun, Yuelan Yin, Xiang Chen, Xinan Jiao
BACKGROUND: Control of Mycobacterium tuberculosis (Mtb) infection requires CD4+ T-cell responses and major histocompatibility complex class II (MHC II) presentation of Mtb antigens (Ags). Dendritic cells (DCs) are the most potent of the Ag-presenting cells and are central to the initiation of T-cell immune responses. Much research has indicated that DCs play an important role in anti-mycobacterial immune responses at early infection time points, but the kinetics of Ag presentation by these cells during these events are incompletely understood...
June 25, 2018: BMC Immunology
https://www.readbyqxmd.com/read/29925312/a-pilot-and-comparative-study-between-pathological-and-serological-levels-of-immunoglobulin-and-complement-among-three-kinds-of-primary-glomerulonephritis
#10
Jin Dong, Tianhao Peng, Jing Gao, Xingwang Jia, Guangtao Yan, Yong Wang
BACKGROUND: Immunoglobulin A nephropathy (IgAN), membranous nephropathy (MN) and minimal-change disease (MCD) are three common types of glomerulonephritis in China. Pathological diagnosis based on renal biopsy is the criterion and the golden standard for diagnosing the sub-types of primary or secondary glomerulonephritis. Immunoglobulin and complements might be used in the differential diagnosis of glomerulonephritis without renal biopsies. However, the relationship between IF intensities of immune proteins and the corresponding serum levels remained unclear, and seldom studies combine histopathological examination results and blood tests together for a predictive purpose...
June 20, 2018: BMC Immunology
https://www.readbyqxmd.com/read/29914371/the-expression-analysis-of-fra-1-gene-and-il-11-protein-in-iranian-patients-with-ulcerative-colitis
#11
Milad Sabzevary-Ghahfarokhi, Mojtaba Shohan, Hedayatollah Shirzad, Ghorbanali Rahimian, Nader Bagheri, Amin Soltani, Fatemeh Deris, Mahdi Ghatreh-Samani, Ehsan Razmara
BACKGROUND: Fra-1 (fosl1) belongs to the activator protein1 (AP-1) family inducing IL-11 expression in oxidative stress condition. IL-11 plays a pivotal role in protecting epithelial barriers integrity. In this study, we investigated the Fra-1 gene expression in the inflamed mucosa of patients with ulcerative colitis (UC) as well as its relation to IL-11 expression. MATERIALS AND METHODS: We enrolled 20 patients and 20 healthy controls with definite UC based on the clinical criteria...
June 18, 2018: BMC Immunology
https://www.readbyqxmd.com/read/29902992/cancer-immunoprevention-from-mice-to-early-clinical-trials
#12
REVIEW
Arianna Palladini, Lorena Landuzzi, Pier-Luigi Lollini, Patrizia Nanni
Cancer immunoprevention is based on the fact that a functioning immune system controls tumor onset and development in humans and animals, thus leading to the idea that the enhancement of immune responses in healthy individuals could effectively reduce cancer risk later in life. Successful primary immunoprevention of tumors caused by hepatitis B and papilloma viruses is already implemented at the population level with specific vaccines. The immunoprevention of human tumors unrelated to infectious agents is an outstanding challenge...
June 15, 2018: BMC Immunology
https://www.readbyqxmd.com/read/29801432/a-qualitatively-validated-mathematical-computational-model-of-the-immune-response-to-the-yellow-fever-vaccine
#13
Carla R B Bonin, Guilherme C Fernandes, Rodrigo W Dos Santos, Marcelo Lobosco
BACKGROUND: Although a safe and effective yellow fever vaccine was developed more than 80 years ago, several issues regarding its use remain unclear. For example, what is the minimum dose that can provide immunity against the disease? A useful tool that can help researchers answer this and other related questions is a computational simulator that implements a mathematical model describing the human immune response to vaccination against yellow fever. METHODS: This work uses a system of ten ordinary differential equations to represent a few important populations in the response process generated by the body after vaccination...
May 25, 2018: BMC Immunology
https://www.readbyqxmd.com/read/29661145/therapeutic-cancer-vaccine-phase-i-clinical-tolerance-study-of-hu-rhegf-rp64k-mont-in-patients-with-newly-diagnosed-advanced-non-small-cell-lung-cancer
#14
Puyuan Xing, Hongyu Wang, Sheng Yang, Xiaohong Han, Yan Sun, Yuankai Shi
BACKGROUND: Hu-rhEGF-rP64k/Mont is a biotechnology product for the treatment of advanced non-small cell lung cancer (NSCLC). The vaccine induces a neutralizing antibody-mediated immune response, against the normal circulating self-protein antigen epidermal growth factor (EGF), which prevents its binding to and activation of the EGF receptor, inhibiting the transduction of the signals that drive cancer cell proliferation, survival and spread. This phase I study aimed to evaluate the safety and the immunological response of Hu-rhEGF-rP64k vaccine in NSCLC patients...
April 16, 2018: BMC Immunology
https://www.readbyqxmd.com/read/29661142/neutrophils-in-primary-gastric-tumors-are-correlated-with-neutrophil-infiltration-in-tumor-draining-lymph-nodes-and-the-systemic-inflammatory-response
#15
Soichiro Hiramatsu, Hiroaki Tanaka, Junya Nishimura, Chie Sakimura, Tatsuro Tamura, Takahiro Toyokawa, Kazuya Muguruma, Masakazu Yashiro, Kosei Hirakawa, Masaichi Ohira
BACKGROUND: Tumor-Associated Neutrophils (TANs) may be able to induce lymphangiogenesis and angiogenesis, although the detailed roles of TANs remain unclear. The Neutrophil-Lymphocyte Ratio (NLR) is an inflammation-based prognostic factor for gastric cancer. This study aimed to investigate the distribution of CD15+ neutrophils in the primary tumor and Tumor-Draining Lymph Nodes (TDLNs), and to examine the association of TANs with the clinicopathological features (including NLR) of patients with gastric cancer...
April 16, 2018: BMC Immunology
https://www.readbyqxmd.com/read/29562882/low-hla-binding-of-diabetes-associated-cd8-t-cell-epitopes-is-increased-by-post-translational-modifications
#16
John Sidney, Jose Luis Vela, Dave Friedrich, Ravi Kolla, Matthias von Herrath, Johnna D Wesley, Alessandro Sette
BACKGROUND: Type 1 diabetes (T1D) is thought to be an autoimmune disease driven by anti-islet antigen responses and mediated by T-cells. Recent published data suggests that T-cell reactivity to modified peptides, effectively neoantigens, may promote T1D. These findings have given more credence to the concept that T1D may not be solely an error of immune recognition but may be propagated by errors in protein processing or in modifications to endogenous peptides occurring as result of hyperglycemia, endoplasmic reticulum (ER) stress, or general beta cell dysfunction...
March 21, 2018: BMC Immunology
https://www.readbyqxmd.com/read/29544447/in-silico-prediction-of-cancer-immunogens-current-state-of-the-art
#17
REVIEW
Irini A Doytchinova, Darren R Flower
Cancer kills 8 million annually worldwide. Although survival rates in prevalent cancers continue to increase, many cancers have no effective treatment, prompting the search for new and improved protocols. Immunotherapy is a new and exciting addition to the anti-cancer arsenal. The successful and accurate identification of aberrant host proteins acting as antigens for vaccination and immunotherapy is a key aspiration for both experimental and computational research. Here we describe key elements of in silico prediction, including databases of cancer antigens and bleeding-edge methodology for their prediction...
March 15, 2018: BMC Immunology
https://www.readbyqxmd.com/read/29490627/utility-of-dominant-epitopes-derived-from-cell-wall-protein-lppz-for-immunodiagnostic-of-pulmonary-tuberculosis
#18
Jinjing Tan, Xiaoguang Wu, Suting Chen, Meng Gu, Hairong Huang, Wentao Yue
BACKGROUND: Serological antibodies tests for tuberculosis (TB) are widely used in developing countries. They appear to have some advantages- faster, simple and could be used for extrapulmonary TB. However, most of current commercial TB serological tests are failed to provide sufficient sensitivity and specificity. Improved serological biomarkers were essential. In this study, we present an approach using peptide array to discover new immunodiagnostic biomarkers based on immunodominant epitopes of TB antigens...
March 1, 2018: BMC Immunology
https://www.readbyqxmd.com/read/29452585/beta-2-adrenergic-receptors-increase-treg-cell-suppression-in-an-ova-induced-allergic-asthma-mouse-model-when-mice-are-moderate-aerobically-exercised
#19
Kari J Dugger, Taylor Chrisman, Sarah L Sayner, Parker Chastain, Kacie Watson, Robert Estes
BACKGROUND: The potency of T regulatory (TREG) cells to inhibit T helper (Th)-driven immune cell responses has been linked to increased intracellular cyclic-AMP (cAMP) levels of TREG cells. In an ovalbumin (OVA)-driven allergic asthma mouse model, moderate aerobic exercise increases TREG cell function in a contact-dependent manner that leads to a significant reduction in chronic inflammation and restoration of lung function. However, the mechanism, whereby exercise increases TREG function, remains unknown and was the focus of these investigations...
February 17, 2018: BMC Immunology
https://www.readbyqxmd.com/read/29433450/pathogen-recognition-by-nk-cells-amplifies-the-pro-inflammatory-cytokine-production-of-monocyte-derived-dc-via-ifn-%C3%AE
#20
Tammy Oth, Thomas H P M Habets, Wilfred T V Germeraad, Marijke I Zonneveld, Gerard M J Bos, Joris Vanderlocht
BACKGROUND: Besides their prominent role in the elimination of infected or malignantly transformed cells, natural killer (NK) cells serve as modulators of adaptive immune responses. Enhancing bidirectional crosstalk between NK cells and dendritic cells (DC) is considered a promising tool to potentiate cancer vaccines. We investigated to what extent direct sensing of viral and bacterial motifs by NK cells contributes to the response of inflammatory DC against the same pathogenic stimulus...
February 13, 2018: BMC Immunology
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