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BMC Genetics

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https://www.readbyqxmd.com/read/27905875/a-nonsense-mutation-in-the-col7a1-gene-causes-epidermolysis-bullosa-in-vorderwald-cattle
#1
Hubert Pausch, Simon Ammermüller, Christine Wurmser, Henning Hamann, Jens Tetens, Cord Drögemüller, Ruedi Fries
BACKGROUND: The widespread use of individual sires for artificial insemination promotes the propagation of recessive conditions. Inadvertent matings between unnoticed carriers of deleterious alleles may result in the manifestation of fatal phenotypes in their progeny. Breeding consultants and farmers reported on Vorderwald calves with a congenital skin disease. The clinical findings in affected calves were compatible with epidermolysis bullosa. RESULTS: Pedigree analysis indicated autosomal recessive inheritance of epidermolysis bullosa in Vorderwald cattle...
December 1, 2016: BMC Genetics
https://www.readbyqxmd.com/read/27903236/erratum-to-adrenal-cortex-expression-quantitative-trait-loci-in-a-german-holstein%C3%A2-%C3%A3-%C3%A2-charolais-cross
#2
Bodo Brand, Markus O Scheinhardt, Juliane Friedrich, Daisy Zimmer, Norbert Reinsch, Siriluck Ponsuksili, Manfred Schwerin, Andreas Ziegler
No abstract text is available yet for this article.
November 30, 2016: BMC Genetics
https://www.readbyqxmd.com/read/27884112/erratum-to-genetic-analysis-of-intestinal-polyp-development-in-collaborative-cross-mice-carrying-the-apc-min-mutation
#3
Alexandra Dorman, Daria Baer, Ian Tomlinson, Richard Mott, Fuad A Iraqi
No abstract text is available yet for this article.
November 24, 2016: BMC Genetics
https://www.readbyqxmd.com/read/27881077/sex-difference-in-egfr-pathways-in-mouse-kidney-potential-impact-on-the-immune-system
#4
Fengxia Liu, Yan Jiao, Yun Jiao, Franklin Garcia-Godoy, Weikuan Gu, Qingyi Liu
BACKGROUND: Epidermal growth factor receptor (Egfr) has been the target of several drugs for cancers. The potential gender differences in genes in the Egfr axis have been suggested in humans and in animal models. Female and male mice from the same recombinant inbred (RI) strain have the same genomic components except the sex difference. A population of different RI mouse strains allows to conduct precise analysis of molecular pathways and regulation of Egfr between female and male mice...
November 24, 2016: BMC Genetics
https://www.readbyqxmd.com/read/27855657/genetic-dissection-of-the-fatty-liver-qtl-fl1sa-by-using-congenic-mice-and-identification-of-candidate-genes-in-the-liver-and-epididymal-fat
#5
Miyako Suzuki, Misato Kobayashi, Tamio Ohno, Shinsaku Kanamori, Soushi Tateishi, Atsushi Murai, Fumihiko Horio
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is a multifactorial disease caused by interactions between environmental and genetic factors. The SMXA-5 mouse is a high-fat diet-induced fatty liver model established from SM/J and A/J strains. We have previously identified Fl1sa, a quantitative trait locus (QTL) for fatty liver on chromosome 12 (centromere-53.06 Mb) of SMXA-5 mice. However, the chromosomal region containing Fl1sa was too broad. The aim of this study was to narrow the Fl1sa region by genetic dissection using novel congenic mice and to identify candidate genes within the narrowed Fl1sa region...
November 17, 2016: BMC Genetics
https://www.readbyqxmd.com/read/27846816/assessing-genotype-phenotype-associations-in-three-dorsal-colour-morphs-in-the-meadow-spittlebug-philaenus-spumarius-l-hemiptera-aphrophoridae-using-genomic-and-transcriptomic-resources
#6
Ana S B Rodrigues, Sara E Silva, Francisco Pina-Martins, João Loureiro, Mariana Castro, Karim Gharbi, Kevin P Johnson, Christopher H Dietrich, Paulo A V Borges, José A Quartau, Chris D Jiggins, Octávio S Paulo, Sofia G Seabra
BACKGROUND: Colour polymorphisms are common among animal species. When combined with genetic and ecological data, these polymorphisms can be excellent systems in which to understand adaptation and the molecular changes underlying phenotypic evolution. The meadow spittlebug, Philaenus spumarius (L.) (Hemiptera, Aphrophoridae), a widespread insect species in the Holarctic region, exhibits a striking dorsal colour/pattern balanced polymorphism. Although experimental crosses have revealed the Mendelian inheritance of this trait, its genetic basis remains unknown...
November 15, 2016: BMC Genetics
https://www.readbyqxmd.com/read/27842509/unravelling-the-genomic-architecture-of-bull-fertility-in-holstein-cattle
#7
Yi Han, Francisco Peñagaricano
BACKGROUND: Fertility is considered an important economic trait in dairy cattle. Most studies have investigated cow fertility while bull fertility has received much less consideration. The main objective of this study was to perform a comprehensive genomic analysis in order to unravel the genomic architecture underlying sire fertility in Holstein dairy cattle. The analysis included the application of alternative genome-wide association mapping approaches and the subsequent use of diverse gene set enrichment tools...
November 14, 2016: BMC Genetics
https://www.readbyqxmd.com/read/27842492/genetic-diversity-and-population-structure-analysis-to-construct-a-core-collection-from-a-large-capsicum-germplasm
#8
Hea-Young Lee, Na-Young Ro, Hee-Jin Jeong, Jin-Kyung Kwon, Jinkwan Jo, Yeaseong Ha, Ayoung Jung, Ji-Woong Han, Jelli Venkatesh, Byoung-Cheorl Kang
BACKGROUND: Conservation of genetic diversity is an essential prerequisite for developing new cultivars with desirable agronomic traits. Although a large number of germplasm collections have been established worldwide, many of them face major difficulties due to large size and a lack of adequate information about population structure and genetic diversity. Core collection with a minimum number of accessions and maximum genetic diversity of pepper species and its wild relatives will facilitate easy access to genetic material as well as the use of hidden genetic diversity in Capsicum...
November 14, 2016: BMC Genetics
https://www.readbyqxmd.com/read/27776497/development-genetic-mapping-and-qtl-association-of-cotton-phya-phyb-and-hy5-specific-caps-and-dcaps-markers
#9
Fakhriddin N Kushanov, Alan E Pepper, John Z Yu, Zabardast T Buriev, Shukhrat E Shermatov, Sukumar Saha, Mauricio Ulloa, Johnie N Jenkins, Abdusattor Abdukarimov, Ibrokhim Y Abdurakhmonov
BACKGROUND: Among SNP markers that become increasingly valuable in molecular breeding of crop plants are the CAPS and dCAPS markers derived from the genes of interest. To date, the number of such gene-based markers is small in polyploid crop plants such as allotetraploid cotton that has A- and D-sub-genomes. The objective of this study was to develop and map new CAPS and dCAPS markers for cotton developmental-regulatory genes that are important in plant breeding programs. RESULTS: Gossypium hirsutum and G...
October 24, 2016: BMC Genetics
https://www.readbyqxmd.com/read/27769161/growth-conditions-that-increase-or-decrease-lifespan-in-saccharomyces-cerevisiae-lead-to-corresponding-decreases-or-increases-in-rates-of-interstitial-deletions-and-non-reciprocal-translocations
#10
Patrick H Maxwell
BACKGROUND: Accumulation of DNA damage, mutations, and chromosomal abnormalities is associated with aging in many organisms. How directly various forms of genomic instability contribute to lifespan in different aging contexts is still under active investigation. Testing whether treatments that alter lifespan change mutation rates early during lifespan could provide support for genomic instability being at least partly responsible for changes in the rates of aging. RESULTS: Rates of mutations, direct repeat recombination, or retrotransposition were measured in young cell populations from two strain backgrounds of Saccharomyces cerevisiae exposed to several growth conditions that shortened or extended yeast chronological lifespan...
October 21, 2016: BMC Genetics
https://www.readbyqxmd.com/read/27765013/a-genome-wide-assessment-of-genetic-diversity-and-population-structure-of-korean-native-cattle-breeds
#11
Aditi Sharma, Seung-Hwan Lee, Dajeong Lim, Han-Ha Chai, Bong-Hwan Choi, Yongmin Cho
BACKGROUND: The native cattle breeds are an important genetic resource for meat and milk production throughout Asia. In Asia cattle were domesticated around 10,000 years ago and in Korea cattle are being raised since 2000 B.C. There are three native breeds of cattle in Korea viz. Brown Hanwoo, Brindle Hanwoo and Jeju Black. While one of these breeds, Brown Hanwoo, is a part of a Food and Agricultural Organization and national genetic evaluation plans, others get little attention. This study is an effort to understand and provide a detailed insight into the population structure and genetic variability of the Korean cattle breeds along with other Asian breeds using various methods...
October 20, 2016: BMC Genetics
https://www.readbyqxmd.com/read/27756221/quantitative-trait-loci-influencing-forking-defects-in-an-outbred-pedigree-of-loblolly-pine
#12
Jin S Xiong, Steven E McKeand, Fikret Isik, Jill Wegrzyn, David B Neale, Zhao-Bang Zeng, Luciano da Costa E Silva, Ross W Whetten
BACKGROUND: The use of wood as an industrial raw material has led to development of plantation forestry, in which trees are planted, managed, and harvested as crops. The productivity of such plantations often exceeds that of less-intensively-managed forests, and land managers have the option of choosing specific planting stock to produce specific types of wood for industrial use. Stem forking, or division of the stem into two or more stems of roughly equal size, is a character trait important in determining the quality of the stem for production of solid wood products...
October 18, 2016: BMC Genetics
https://www.readbyqxmd.com/read/27737627/a-high-density-genetic-map-reveals-variation-in-recombination-rate-across-the-genome-of-daphnia-magna
#13
Marinela Dukić, Daniel Berner, Marius Roesti, Christoph R Haag, Dieter Ebert
BACKGROUND: Recombination rate is an essential parameter for many genetic analyses. Recombination rates are highly variable across species, populations, individuals and different genomic regions. Due to the profound influence that recombination can have on intraspecific diversity and interspecific divergence, characterization of recombination rate variation emerges as a key resource for population genomic studies and emphasises the importance of high-density genetic maps as tools for studying genome biology...
October 13, 2016: BMC Genetics
https://www.readbyqxmd.com/read/27717311/formation-of-diploid-and-triploid-hybrid-groupers-hybridization-of-epinephelus-coioides-%C3%A2-%C3%A2-%C3%A3-%C3%A2-epinephelus-lanceolatus-%C3%A2-and-their-5s-gene-analysis
#14
Wen Huang, Qinbo Qin, Huirong Yang, Shuisheng Li, Chaoqun Hu, Yude Wang, Yong Zhang, Shaojun Liu, Haoran Lin
BACKGROUND: Interspecies hybridization is widely used to achieve heterosis or hybrid vigor, which has been observed and harnessed by breeders for centuries. Natural allopolyploid hybrids generally exhibit more superior heterosis than both the diploid progenies and their parental species. However, polyploid formation processes have been long ignored, the genetic basis of heterosis in polyploids remains elusive. RESULTS: In the present study, triploid hybrids had been demonstrated to contain two sets of chromosomes from mother species and one set from father species...
October 7, 2016: BMC Genetics
https://www.readbyqxmd.com/read/27716033/adrenal-cortex-expression-quantitative-trait-loci-in-a-german-holstein-%C3%A3-charolais-cross
#15
Bodo Brand, Markus O Scheinhardt, Juliane Friedrich, Daisy Zimmer, Norbert Reinsch, Siriluck Ponsuksili, Manfred Schwerin, Andreas Ziegler
BACKGROUND: The importance of the adrenal gland in regard to lactation and reproduction in cattle has been recognized early. Caused by interest in animal welfare and the impact of stress on economically important traits in farm animals the adrenal gland and its function within the stress response is of increasing interest. However, the molecular mechanisms and pathways involved in stress-related effects on economically important traits in farm animals are not fully understood. Gene expression is an important mechanism underlying complex traits, and genetic variants affecting the transcript abundance are thought to influence the manifestation of an expressed phenotype...
October 6, 2016: BMC Genetics
https://www.readbyqxmd.com/read/27716028/genetic-signals-of-high-altitude-adaptation-in-amphibians-a-comparative-transcriptome-analysis
#16
Weizhao Yang, Yin Qi, Jinzhong Fu
BACKGROUND: High-altitude adaptation provides an excellent system for studying how organisms cope with multiple environmental stressors and interacting genetic modifications. To explore the genetic basis of high-altitude adaptation in poikilothermic animals, we acquired transcriptome sequences from a high-altitude population and a low-altitude population of the Asiatic toad (Bufo gargarizans). Transcriptome data from another high-altitude amphibian, Rana kukunoris and its low-altitude relative R...
October 3, 2016: BMC Genetics
https://www.readbyqxmd.com/read/27716024/genetic-composition-of-captive-panda-population
#17
Jiandong Yang, Fujun Shen, Rong Hou, Yang Da
BACKGROUND: A major function of the captive panda population is to preserve the genetic diversity of wild panda populations in their natural habitats. Understanding the genetic composition of the captive panda population in terms of genetic contributions from the wild panda populations provides necessary knowledge for breeding plans to preserve the genetic diversity of the wild panda populations. RESULTS: The genetic contributions from different wild populations to the captive panda population were highly unbalanced, with Qionglai accounting for 52...
October 3, 2016: BMC Genetics
https://www.readbyqxmd.com/read/27514831/genome-wide-association-study-of-copy-number-variation-with-lung-function-identifies-a-novel-signal-of-association-near-banp-for-forced-vital-capacity
#18
Nick Shrine, Martin D Tobin, Claudia Schurmann, María Soler Artigas, Jennie Hui, Terho Lehtimäki, Olli T Raitakari, Craig E Pennell, Qi Wei Ang, David P Strachan, Georg Homuth, Sven Gläser, Stephan B Felix, David M Evans, John Henderson, Raquel Granell, Lyle J Palmer, Jennifer Huffman, Caroline Hayward, Generation Scotland, Anders Malarstig, Bill Musk, Alan L James, Louise V Wain
BACKGROUND: Genome-wide association studies of Single Nucleotide Polymorphisms (SNPs) have identified 55 SNPs associated with lung function. However, little is known about the effect of copy number variants (CNVs) on lung function, although CNVs represent a significant proportion of human genetic polymorphism. To assess the effect of CNVs on lung function quantitative traits, we measured copy number at 2788 previously characterised, common copy number variable regions in 6 independent cohorts (n = 24,237) using intensity data from SNP genotyping experiments...
August 11, 2016: BMC Genetics
https://www.readbyqxmd.com/read/27296613/multiethnic-genome-wide-association-study-identifies-ethnic-specific-associations-with-body-mass-index-in-hispanics-and-african-americans
#19
Yasmmyn D Salinas, Leyao Wang, Andrew T DeWan
BACKGROUND: Genome-wide association studies of obesity have typically assumed fixed genetic effects across ethnicities, rarely attempting to thoroughly compare and contrast findings across various ethnic groups. Therefore, our study aimed to identify novel genetic associations with body mass index (BMI), a common measure of obesity, and explore their cross-ethnic generalizability in a multiethnic population. To that end, we conducted ​ethnic-specific genome-wide association analyses among 1235 Hispanic, 706 Asian, 1549 African American, and 2395 European American subjects from the Multi-ethnic Study of Atherosclerosis (MESA)...
June 13, 2016: BMC Genetics
https://www.readbyqxmd.com/read/27044251/exploring-tomato-solanum-pennellii-introgression-lines-for-residual-biomass-and-enzymatic-digestibility-traits
#20
G Caruso, L D Gomez, F Ferriello, A Andolfi, C Borgonuovo, A Evidente, R Simister, S J McQueen-Mason, D Carputo, L Frusciante, M R Ercolano
BACKGROUND: Residual biomass production for fuel conversion represents a unique opportunity to avoid concerns about compromising food supply by using dedicated feedstock crops. Developing tomato varieties suitable for both food consumption and fuel conversion requires the establishment of new selection methods. RESULTS: A tomato Solanum pennellii introgression population was assessed for fruit yield, biomass phenotypic diversity, and for saccharification potential...
April 5, 2016: BMC Genetics
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