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BMC Developmental Biology

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https://www.readbyqxmd.com/read/27881074/changes-of-gonadotropin-releasing-hormone-receptor-2-during-the-anadromous-spawning-migration-in-coilia-nasus
#1
Jin-Rong Duan, Di-An Fang, Min-Ying Zhang, Kai Liu, Yan-Feng Zhou, Dong-Po Xu, Pao Xu, Da-Peng Li
BACKGROUND: An increase in the activity of the pituitary-gonad axis (PG-axis) and gonad development are essential for the onset of spawning migration in teleosts. In the fish Coilia nasus, gonad development and spawning migration up the Yangtze River occurs by the end of each summer. We hypothesized that gonadotropin releasing hormones receptor 2 (GnRH-R2), which together produce a signal that interacts with the PG-axis, may help to regulate spawning migration processes. RESULTS: In this regard, we (1) characterized the gonadosomatic index (GSI) in the anadromous fish C...
November 24, 2016: BMC Developmental Biology
https://www.readbyqxmd.com/read/27863467/microarray-analysis-reveals-a-potential-role-of-lncrnas-expression-in-cardiac-cell-proliferation
#2
Jue Wang, Zhimin Geng, Jiakan Weng, Longjie Shen, Ming Li, Xueli Cai, Chengchao Sun, Maoping Chu
BACKGROUND: Long non-coding RNAs (LncRNAs) have been identified to play important roles in epigenetic processes that underpin organogenesis. However, the role of LncRNAs in the regulation of transition from fetal to adult life of human heart has not been evaluated. METHODS: Immunofiuorescent staining was used to determine the extent of cardiac cell proliferation. Human LncRNA microarrays were applied to define gene expression signatures of the fetal (13-17 weeks of gestation, n = 4) and adult hearts (30-40 years old, n = 4)...
November 18, 2016: BMC Developmental Biology
https://www.readbyqxmd.com/read/27809766/diversity-of-human-and-mouse-homeobox-gene-expression-in-development-and-adult-tissues
#3
Thomas L Dunwell, Peter W H Holland
BACKGROUND: Homeobox genes encode a diverse set of transcription factors implicated in a vast range of biological processes including, but not limited to, embryonic cell fate specification and patterning. Although numerous studies report expression of particular sets of homeobox genes, a systematic analysis of the tissue specificity of homeobox genes is lacking. RESULTS: Here we analyse publicly-available transcriptome data from human and mouse developmental stages, and adult human tissues, to identify groups of homeobox genes with similar expression patterns...
November 3, 2016: BMC Developmental Biology
https://www.readbyqxmd.com/read/27793090/left-right-axis-asymmetry-determining-human-cryptic-gene-is-transcriptionally-repressed-by-snail
#4
Kartik Gupta, Vijaya Satish Sekhar Pilli, Gopala Krishna Aradhyam
BACKGROUND: Establishment of the left-right axis is important for positioning organs asymmetrically in the developing vertebrate-embryo. A number of factors like maternally deposited molecules have emerged essential in initiating the specification of the axis; the downstream events, however, are regulated by signal-transduction and gene-expression changes identifying which remains a crucial challenge. The EGF-CFC family member Cryptic, that functions as a co-receptor for some TGF-beta ligands, is developmentally expressed in higher mammals and mutations in the gene cause loss or change in left-right axis asymmetry...
October 28, 2016: BMC Developmental Biology
https://www.readbyqxmd.com/read/27784267/expression-of-ribosomopathy-genes-during-xenopus-tropicalis-embryogenesis
#5
Andrew Robson, Nick D L Owens, Susan J Baserga, Mustafa K Khokha, John N Griffin
BACKGROUND: Because ribosomes are ubiquitously required for protein production, it was long assumed that any inherited defect in ribosome manufacture would be embryonically lethal. However, several human congenital diseases have been found to be associated with mutations in ribosome biogenesis factors. Surprisingly, despite the global requirement for ribosomes, these "ribosomopathies" are characterized by distinct and tissue specific phenotypes. The reasons for such tissue proclivity in ribosomopathies remain mysterious but may include differential expression of ribosome biogenesis factors in distinct tissues...
October 26, 2016: BMC Developmental Biology
https://www.readbyqxmd.com/read/27756203/mice-lacking-the-conserved-transcription-factor-grainyhead-like-3-grhl3-display-increased-apposition-of-the-frontal-and-parietal-bones-during-embryonic-development
#6
Stephen J Goldie, Benedicta D Arhatari, Peter Anderson, Alana Auden, Darren D Partridge, Stephen M Jane, Sebastian Dworkin
BACKGROUND: Increased apposition of the frontal and parietal bones of the skull during embryogenesis may be a risk factor for the subsequent development of premature skull fusion, or craniosynostosis. Human craniosynostosis is a prevalent, and often serious embryological and neonatal pathology. Other than known mutations in a small number of contributing genes, the aetiology of craniosynostosis is largely unknown. Therefore, the identification of novel genes which contribute to normal skull patterning, morphology and premature suture apposition is imperative, in order to fully understand the genetic regulation of cranial development...
October 18, 2016: BMC Developmental Biology
https://www.readbyqxmd.com/read/27737629/lack-of-effects-of-ooplasm-transfer-on-early-development-of-interspecies-somatic-cell-nuclear-transfer-bison-embryos
#7
L Antonio González-Grajales, Laura A Favetta, W Allan King, Gabriela F Mastromonaco
BACKGROUND: Successful development of iSCNT (interspecies somatic cell nuclear transfer) embryos depends on complex interactions between ooplasmic and nuclear components, which can be compromised by genetic divergence. Transfer of ooplasm matching the genetic background of the somatic cell in iSCNT embryos is a valuable tool to study the degree of incompatibilities between nuclear and ooplasmic components. This study investigated the effects of ooplasm transfer (OT) on cattle (Bos taurus) and plains bison (Bison bison bison) embryos produced by iSCNT and supplemented with or without ooplasm from cattle or plains bison oocytes...
October 13, 2016: BMC Developmental Biology
https://www.readbyqxmd.com/read/27733125/distinct-shape-shifting-regimes-of-bowl-shaped-cell-sheets-embryonic-inversion-in-the-multicellular-green-alga-pleodorina
#8
Stephanie Höhn, Armin Hallmann
BACKGROUND: The multicellular volvocine alga Pleodorina is intermediate in organismal complexity between its unicellular relative, Chlamydomonas, and its multicellular relative, Volvox, which shows complete division of labor between different cell types. The volvocine green microalgae form a group of genera closely related to the genus Volvox within the order Volvocales (Chlorophyta). Embryos of multicellular volvocine algae consist of a cellular monolayer that, depending on the species, is either bowl-shaped or comprises a sphere...
October 13, 2016: BMC Developmental Biology
https://www.readbyqxmd.com/read/27724845/bmp-smad-signalling-output-is-highly-regionalized-in-cardiovascular-and-lymphatic-endothelial-networks
#9
Karen Beets, Michael W Staring, Nathan Criem, Elke Maas, Niels Schellinx, Susana M Chuva de Sousa Lopes, Lieve Umans, An Zwijsen
BACKGROUND: Bone morphogenetic protein (BMP) signalling has emerged as a fundamental pathway in endothelial cell biology and deregulation of this pathway is implicated in several vascular disorders. BMP signalling output in endothelial cells is highly context- and dose-dependent. Phosphorylation of the BMP intracellular effectors, SMAD1/5/9, is routinely used to monitor BMP signalling activity. To better understand the in vivo context-dependency of BMP-SMAD signalling, we investigated differences in BMP-SMAD transcriptional activity in different vascular beds during mouse embryonic and postnatal stages...
October 10, 2016: BMC Developmental Biology
https://www.readbyqxmd.com/read/27680968/dynamics-of-nuclear-receptor-gene-expression-during-pacific-oyster-development
#10
Susanne Vogeler, Tim P Bean, Brett P Lyons, Tamara S Galloway
BACKGROUND: Nuclear receptors are a highly conserved set of ligand binding transcription factors, with essential roles regulating aspects of vertebrate and invertebrate biology alike. Current understanding of nuclear receptor regulated gene expression in invertebrates remains sparse, limiting our ability to elucidate gene function and the conservation of developmental processes across phyla. Here, we studied nuclear receptor expression in the early life stages of the Pacific oyster, Crassostrea gigas, to identify at which specific key stages nuclear receptors are expressed RESULTS: We used quantitative RT-PCR to determine the expression profiles of 34 nuclear receptors, revealing three developmental key stages, during which nuclear receptor expression is dynamically regulated: embryogenesis, mid development from gastrulation to trochophore larva, and late larval development prior to metamorphosis...
September 29, 2016: BMC Developmental Biology
https://www.readbyqxmd.com/read/27662828/generation-and-characterization-of-a-novel-transgenic-mouse-harboring-conditional-nuclear-factor-kappa-b-rela-knockout-alleles
#11
Talha Ijaz, Maki Wakamiya, Hong Sun, Adrian Recinos, Ronald G Tilton, Allan R Brasier
BACKGROUND: Nuclear Factor-Kappa B (NF-kB) is a family of transcription factors that are important in embryonic development, inflammation, epithelial-to-mesenchymal transition and cancer. The 65 kDa RelA subunit is the major transcriptional activator of the NF-kB pathways. Whole-body deficiency of RelA leads to massive apoptosis of liver hepatocytes and death in utero. To study the role of RelA in physiology and in disease states in a manner that circumvents this embryonic lethal phenotype, we have generated a mouse with RelA conditional knockout (CKO) alleles containing loxP sites that are deleted by activated Cre recombinase...
September 23, 2016: BMC Developmental Biology
https://www.readbyqxmd.com/read/27412523/relating-proton-pumps-with-gap-junctions-colocalization-of-ductin-the-channel-forming-subunit-c-of-v-atpase-with-subunit-a-and-with-innexins-2-and-3-during-drosophila-oogenesis
#12
Julia Lautemann, Johannes Bohrmann
BACKGROUND: Ion-transport mechanisms and gap junctions are known to cooperate in creating bioelectric phenomena, like pH gradients, voltage gradients and ion fluxes within single cells, tissues, organs, and whole organisms. Such phenomena have been shown to play regulatory roles in a variety of developmental and regenerative processes. Using Drosophila oogenesis as a model system, we aim at characterizing in detail the mechanisms underlying bioelectric phenomena in order to reveal their regulatory functions...
July 13, 2016: BMC Developmental Biology
https://www.readbyqxmd.com/read/27178071/effects-of-usag-1-and-bmp7-deficiencies-on-murine-tooth-morphogenesis
#13
Kazuyuki Saito, Katsu Takahashi, Masakazu Asahara, Honoka Kiso, Yumiko Togo, Hiroko Tsukamoto, Boyen Huang, Manabu Sugai, Akira Shimizu, Masaharu Motokawa, Harold C Slavkin, Kazuhisa Bessho
BACKGROUND: Wnt5a and Mrfzb1 genes are involved in the regulation of tooth size, and their expression levels are similar to that of Bmp7 during morphogenesis, including during the cap and early bell stages of tooth formation. We previously reported that Usag-1-deficient mice form supernumerary maxillary incisors. Thus, we hypothesized that BMP7 and USAG-1 signaling molecules may play important roles in tooth morphogenesis. In this study, we established double genetically modified mice to examine the in vivo inter-relationships between Bmp7 and Usag-1...
May 13, 2016: BMC Developmental Biology
https://www.readbyqxmd.com/read/26912062/computational-prediction-and-experimental-validation-of-novel-hedgehog-responsive-enhancers-linked-to-genes-of-the-hedgehog-pathway
#14
Katherine Gurdziel, Kyle R Vogt, Gary Schneider, Neil Richards, Deborah L Gumucio
BACKGROUND: The Hedgehog (Hh) signaling pathway, acting through three homologous transcription factors (GLI1, GLI2, GLI3) in vertebrates, plays multiple roles in embryonic organ development and adult tissue homeostasis. At the level of the genome, GLI factors bind to specific motifs in enhancers, some of which are hundreds of kilobases removed from the gene promoter. These enhancers integrate the Hh signal in a context-specific manner to control the spatiotemporal pattern of target gene expression...
February 24, 2016: BMC Developmental Biology
https://www.readbyqxmd.com/read/27653971/the-e3-ubiquitin-ligase-hace1-is-required-for-early-embryonic-development-in-xenopus-laevis
#15
Akira Iimura, Fuhito Yamazaki, Toshiyasu Suzuki, Tatsuya Endo, Eisuke Nishida, Morioh Kusakabe
BACKGROUND: HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 (HACE1) regulates a wide variety of cellular processes. It has been shown that one of the targets of HACE1 is the GTP-bound form of the small GTPase Rac1. However, the role of HACE1 in early development remains unknown. RESULTS: In situ hybridization revealed that Xenopus laevis hace1 is specifically expressed in the ectoderm at the blastula and gastrula stages and in the epidermis, branchial arch, kidney, and central nervous system at the tailbud stage...
2016: BMC Developmental Biology
https://www.readbyqxmd.com/read/27582005/impairment-of-wnt11-function-leads-to-kidney-tubular-abnormalities-and-secondary-glomerular-cystogenesis
#16
Irina I Nagy, Qi Xu, Florence Naillat, Nsrein Ali, Ilkka Miinalainen, Anatoly Samoylenko, Seppo J Vainio
BACKGROUND: Wnt11 is a member of the Wnt family of secreted signals controlling the early steps in ureteric bud (UB) branching. Due to the reported lethality of Wnt11 knockout embryos in utero, its role in later mammalian kidney organogenesis remains open. The presence of Wnt11 in the emerging tubular system suggests that it may have certain roles later in the development of the epithelial ductal system. RESULTS: The Wnt11 knockout allele was backcrossed with the C57Bl6 strain for several generations to address possible differences in penetrance of the kidney phenotypes...
2016: BMC Developmental Biology
https://www.readbyqxmd.com/read/27553860/erratum-to-in-vivo-role-of-different-domains-and-of-phosphorylation-in-the-transcription-factor-nkx2-1
#17
Daniel Silberschmidt, Alina Rodriguez-Mallon, Prathiba Mithboakar, Gaetano Calì, Elena Amendola, Remo Sanges, Mariastella Zannini, Marzia Scarfò, Pasquale De Luca, Lucio Nitsch, Roberto Di Lauro, Mario De Felice
No abstract text is available yet for this article.
2016: BMC Developmental Biology
https://www.readbyqxmd.com/read/27553781/cilia-are-required-for-asymmetric-nodal-induction-in-the-sea-urchin-embryo
#18
Matthias Tisler, Franziska Wetzel, Sabrina Mantino, Stanislav Kremnyov, Thomas Thumberger, Axel Schweickert, Martin Blum, Philipp Vick
BACKGROUND: Left-right (LR) organ asymmetries are a common feature of metazoan animals. In many cases, laterality is established by a conserved asymmetric Nodal signaling cascade during embryogenesis. In most vertebrates, asymmetric nodal induction results from a cilia-driven leftward fluid flow at the left-right organizer (LRO), a ciliated epithelium present during gastrula/neurula stages. Conservation of LRO and flow beyond the vertebrates has not been reported yet. RESULTS: Here we study sea urchin embryos, which use nodal to establish larval LR asymmetry as well...
2016: BMC Developmental Biology
https://www.readbyqxmd.com/read/27484899/brg1-interacts-with-gli2-and-binds-mef2c-gene-in-a-hedgehog-signalling-dependent-manner-during-in-vitro-cardiomyogenesis
#19
Joel Vincent Fair, Anastassia Voronova, Neven Bosiljcic, Rashida Rajgara, Alexandre Blais, Ilona Sylvia Skerjanc
BACKGROUND: The Hedgehog (HH) signalling pathway regulates cardiomyogenesis in vivo and in differentiating P19 embryonal carcinoma (EC) cells, a mouse embryonic stem (mES) cell model. To further assess the transcriptional role of HH signalling during cardiomyogenesis in stem cells, we studied the effects of overexpressing GLI2, a primary transducer of the HH signalling pathway, in mES cells. RESULTS: Stable GLI2 overexpression resulted in an enhancement of cardiac progenitor-enriched genes, Mef2c, Nkx2-5, and Tbx5 during mES cell differentiation...
2016: BMC Developmental Biology
https://www.readbyqxmd.com/read/27461387/efficient-talen-mediated-myostatin-gene-editing-in-goats
#20
Baoli Yu, Rui Lu, Yuguo Yuan, Ting Zhang, Shaozheng Song, Zhengqiang Qi, Bin Shao, Mengmin Zhu, Fei Mi, Yong Cheng
BACKGROUND: Myostatin (MSTN) encodes a negative regulator of skeletal muscle mass that might have applications for promoting muscle growth in livestock. In this study, we aimed to test whether targeted MSTN editing, mediated by transcription activator-like effector nucleases (TALENs), is a viable approach to create myostatin-modified goats (Capra hircus). RESULTS: We obtained a pair of TALENs (MTAL-2) that could recognize and cut the targeted MSTN site in the goat genome...
2016: BMC Developmental Biology
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