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BMC Developmental Biology

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https://www.readbyqxmd.com/read/28728543/integrative-analysis-of-the-pekin-duck-anas-anas-micrornaome-during-feather-follicle-development
#1
Xingyong Chen, Kai Ge, Min Wang, Cheng Zhang, Zhaoyu Geng
BACKGROUND: The quality and yield of duck feathers are very important economic traits that might be controlled by miRNA regulation. The aim of the present study was to investigate the mechanism underlying the crosstalk between individual miRNAs and the activity of signaling pathways that control the growth of duck feathers during different periods. We therefore conducted a comprehensive investigation using Solexa sequencing technology on the Pekin duck microRNAome over six stages of feather development at days 11, 15, and 20 of embryonic development (during the hatching period), and at 1 day and 4 and 10 weeks posthatch...
July 20, 2017: BMC Developmental Biology
https://www.readbyqxmd.com/read/28716037/phylogeny-expression-patterns-and-regulation-of-dna-methyltransferases-in-early-development-of-the-flatfish-solea-senegalensis
#2
Joana Firmino, Carlos Carballo, Paula Armesto, Marco A Campinho, Deborah M Power, Manuel Manchado
BACKGROUND: The identification of DNA methyltransferases (Dnmt) expression patterns during development and their regulation is important to understand the epigenetic mechanisms that modulate larval plasticity in marine fish. In this study, dnmt1 and dnmt3 paralogs were identified in the flatfish Solea senegalensis and expression patterns in early developmental stages and juveniles were determined. Additionally, the regulation of Dnmt transcription by a specific inhibitor (5-aza-2'-deoxycytidine) and temperature was evaluated...
July 17, 2017: BMC Developmental Biology
https://www.readbyqxmd.com/read/28676034/cathepsin-b-inhibitor-improves-developmental-competency-and-cryo-tolerance-of-in-vitro-ovine-embryos
#3
M Pezhman, S M Hosseini, S Ostadhosseini, Sh Rouhollahi Varnosfaderani, F Sefid, M H Nasr-Esfahani
BACKGROUND: Cathepsin B is a lysosomal cysteine protease involved in apoptosis and oocytes which have lower developmental competence show higher expression of Cathepsin B. Furthermore, expression of Cathepsin B show a decreasing trend from oocyte toward blastocyst stage. RESULTS: Present study assessed the effect of cathepsin B inhibitor, E-64, on developmental competency and cryo-survival of pre-implantation ovine IVF derived embryos. Cathepsin B inhibitor was added during day 3 to 8 of development...
July 4, 2017: BMC Developmental Biology
https://www.readbyqxmd.com/read/28673232/expression-of-ciona-intestinalis-aox-causes-male-reproductive-defects-in-drosophila-melanogaster
#4
Sina Saari, Ana Andjelković, Geovana S Garcia, Howard T Jacobs, Marcos T Oliveira
BACKGROUND: Mitochondrial alternative respiratory-chain enzymes are phylogenetically widespread, and buffer stresses affecting oxidative phosphorylation in species that possess them. However, they have been lost in the evolutionary lineages leading to vertebrates and arthropods, raising the question as to what survival or reproductive disadvantages they confer. Recent interest in using them in therapy lends a biomedical dimension to this question. METHODS: Here, we examined the impact of the expression of Ciona intestinalis alternative oxidase, AOX, on the reproductive success of Drosophila melanogaster males...
July 3, 2017: BMC Developmental Biology
https://www.readbyqxmd.com/read/28662681/comparison-of-two-related-lines-of-taugfp-transgenic-mice-designed-for-lineage-tracing
#5
Linda Sharp, Thomas Pratt, Gillian E MacKay, Margaret A Keighren, Jean H Flockhart, Emma J Chandler, David J Price, John O Mason, John D West
BACKGROUND: The tauGFP reporter fusion protein is produced nearly ubiquitously by the TgTP6.3 transgene in TP6.3 mice and its localisation to microtubules offers some advantages over soluble GFP as a lineage marker. However, TgTP6.3 (Tg/Tg) homozygotes are not viable and TgTP6.3 (Tg/-) hemizygotes are smaller than wild-type. TP6.4 mice carry the TgTP6.4 transgene, which was produced with the same construct used to generate TgTP6.3, so we investigated whether TgTP6.4 had any advantages over TgTP6...
June 29, 2017: BMC Developmental Biology
https://www.readbyqxmd.com/read/28610558/the-many-faces-of-pluripotency-in-vitro-adaptations-of-a-continuum-of-in-vivo-states
#6
REVIEW
Sophie Morgani, Jennifer Nichols, Anna-Katerina Hadjantonakis
Pluripotency defines the propensity of a cell to differentiate into, and generate, all somatic, as well as germ cells. The epiblast of the early mammalian embryo is the founder population of all germ layer derivatives and thus represents the bona fide in vivo pluripotent cell population. The so-called pluripotent state spans several days of development and is lost during gastrulation as epiblast cells make fate decisions towards a mesoderm, endoderm or ectoderm identity. It is now widely recognized that the features of the pluripotent population evolve as development proceeds from the pre- to post-implantation period, marked by distinct transcriptional and epigenetic signatures...
June 13, 2017: BMC Developmental Biology
https://www.readbyqxmd.com/read/28446132/pcsk5-is-required-in-the-early-cranio-cardiac-mesoderm-for-heart-development
#7
Dorota Szumska, Milena Cioroch, Angela Keeling, Annik Prat, Nabil G Seidah, Shoumo Bhattacharya
BACKGROUND: Loss of proprotein convertase subtilisin/kexin type 5 (Pcsk5) results in multiple developmental anomalies including cardiac malformations, caudal regression, pre-sacral mass, renal agenesis, anteroposterior patterning defects, and tracheo-oesophageal and anorectal malformations, and is a model for VACTERL/caudal regression/Currarino syndromes (VACTERL association - Vertebral anomalies, Anal atresia, Cardiac defects, Tracheoesophageal fistula and/or Esophageal atresia, Renal & Radial anomalies and Limb defects)...
April 26, 2017: BMC Developmental Biology
https://www.readbyqxmd.com/read/28407732/transcriptome-profiling-reveals-expression-signatures-of-cranial-neural-crest-cells-arising-from-different-axial-levels
#8
Rachael Lumb, Sam Buckberry, Genevieve Secker, David Lawrence, Quenten Schwarz
BACKGROUND: Cranial neural crest cells (NCCs) are a unique embryonic cell type which give rise to a diverse array of derivatives extending from neurons and glia through to bone and cartilage. Depending on their point of origin along the antero-posterior axis cranial NCCs are rapidly sorted into distinct migratory streams that give rise to axial specific structures. These migratory streams mirror the underlying segmentation of the brain with NCCs exiting the diencephalon and midbrain following distinct paths compared to those exiting the hindbrain rhombomeres (r)...
April 13, 2017: BMC Developmental Biology
https://www.readbyqxmd.com/read/28193178/nodal-and-bmp-expression-during-the-transition-to-pentamery-in-the-sea-urchin-heliocidaris-erythrogramma-insights-into-patterning-the-enigmatic-echinoderm-body-plan
#9
Demian Koop, Paula Cisternas, Valerie B Morris, Dario Strbenac, Jean Yee Hwa Yang, Gregory A Wray, Maria Byrne
BACKGROUND: The molecular mechanisms underlying the development of the unusual echinoderm pentameral body plan and their likeness to mechanisms underlying the development of the bilateral plans of other deuterostomes are of interest in tracing body plan evolution. In this first study of the spatial expression of genes associated with Nodal and BMP2/4 signalling during the transition to pentamery in sea urchins, we investigate Heliocidaris erythrogramma, a species that provides access to the developing adult rudiment within days of fertilization...
February 13, 2017: BMC Developmental Biology
https://www.readbyqxmd.com/read/28158974/a-compendium-of-developmental-gene-expression-in-lake-malawi-cichlid-fishes
#10
R F Bloomquist, T E Fowler, J B Sylvester, R J Miro, J T Streelman
BACKGROUND: Lake Malawi cichlids represent one of a growing number of vertebrate models used to uncover the genetic and developmental basis of trait diversity. Rapid evolutionary radiation has resulted in species that share similar genomes but differ markedly in phenotypes including brains and behavior, nuptial coloration and the craniofacial skeleton. Research has begun to identify the genes, as well as the molecular and developmental pathways that underlie trait divergence. RESULTS: We assemble a compendium of gene expression for Lake Malawi cichlids, across pharyngula (the phylotypic stage) and larval stages of development, encompassing hundreds of gene transcripts...
February 3, 2017: BMC Developmental Biology
https://www.readbyqxmd.com/read/28077087/embryogenesis-in-the-parasitic-nematode-heterodera-glycines-is-independent-of-host-derived-hatching-stimulation
#11
Sita Thapa, Jayna A Patel, Ursula Reuter-Carlson, Nathan E Schroeder
BACKGROUND: Many parasites regulate their development to synchronize their life cycle with a compatible host. The parasitic nematode Heterodera glycines displays incomplete host-mediated hatching behavior wherein some H. glycines individuals hatch only in the presence of a host-derived cue while others hatch in water alone. Furthermore, H. glycines shows variable hatching behavior based on oviposition location. The mechanisms regulating this hatching variability are unknown. In this study, we established a detailed timeline of the H...
January 11, 2017: BMC Developmental Biology
https://www.readbyqxmd.com/read/28077066/the-essential-requirement-of-an-animal-heme-peroxidase-protein-during-the-wing-maturation-process-in-drosophila
#12
Dondra Bailey, Mohammed Abul Basar, Sanjay Nag, Nivedita Bondhu, Shaloei Teng, Atanu Duttaroy
BACKGROUND: Thus far, a handful of genes have been shown to be related to the wing maturation process in insects. A novel heme peroxidase enzyme known as curly suppressor (Cysu)(formerly CG5873), have been characterized in this report because it is involved in wing morphogenesis. Using bioinformatics tools we found that Cysu is remarkably conserved in the genus Drosophila (>95%) as well as in invertebrates (>70%), although its vertebrate orthologs show poor homology. Time-lapse imaging and histochemical analyses have confirmed that the defective wing phenotype of Cysu is not a result of any underlying cellular alterations; instead, its wings fail to expand in mature adults...
January 11, 2017: BMC Developmental Biology
https://www.readbyqxmd.com/read/27881074/changes-of-gonadotropin-releasing-hormone-receptor-2-during-the-anadromous-spawning-migration-in-coilia-nasus
#13
Jin-Rong Duan, Di-An Fang, Min-Ying Zhang, Kai Liu, Yan-Feng Zhou, Dong-Po Xu, Pao Xu, Da-Peng Li
BACKGROUND: An increase in the activity of the pituitary-gonad axis (PG-axis) and gonad development are essential for the onset of spawning migration in teleosts. In the fish Coilia nasus, gonad development and spawning migration up the Yangtze River occurs by the end of each summer. We hypothesized that gonadotropin releasing hormones receptor 2 (GnRH-R2), which together produce a signal that interacts with the PG-axis, may help to regulate spawning migration processes. RESULTS: In this regard, we (1) characterized the gonadosomatic index (GSI) in the anadromous fish C...
November 24, 2016: BMC Developmental Biology
https://www.readbyqxmd.com/read/27863467/microarray-analysis-reveals-a-potential-role-of-lncrnas-expression-in-cardiac-cell-proliferation
#14
Jue Wang, Zhimin Geng, Jiakan Weng, Longjie Shen, Ming Li, Xueli Cai, Chengchao Sun, Maoping Chu
BACKGROUND: Long non-coding RNAs (LncRNAs) have been identified to play important roles in epigenetic processes that underpin organogenesis. However, the role of LncRNAs in the regulation of transition from fetal to adult life of human heart has not been evaluated. METHODS: Immunofiuorescent staining was used to determine the extent of cardiac cell proliferation. Human LncRNA microarrays were applied to define gene expression signatures of the fetal (13-17 weeks of gestation, n = 4) and adult hearts (30-40 years old, n = 4)...
November 18, 2016: BMC Developmental Biology
https://www.readbyqxmd.com/read/27809766/diversity-of-human-and-mouse-homeobox-gene-expression-in-development-and-adult-tissues
#15
Thomas L Dunwell, Peter W H Holland
BACKGROUND: Homeobox genes encode a diverse set of transcription factors implicated in a vast range of biological processes including, but not limited to, embryonic cell fate specification and patterning. Although numerous studies report expression of particular sets of homeobox genes, a systematic analysis of the tissue specificity of homeobox genes is lacking. RESULTS: Here we analyse publicly-available transcriptome data from human and mouse developmental stages, and adult human tissues, to identify groups of homeobox genes with similar expression patterns...
November 3, 2016: BMC Developmental Biology
https://www.readbyqxmd.com/read/27793090/left-right-axis-asymmetry-determining-human-cryptic-gene-is-transcriptionally-repressed-by-snail
#16
Kartik Gupta, Vijaya Satish Sekhar Pilli, Gopala Krishna Aradhyam
BACKGROUND: Establishment of the left-right axis is important for positioning organs asymmetrically in the developing vertebrate-embryo. A number of factors like maternally deposited molecules have emerged essential in initiating the specification of the axis; the downstream events, however, are regulated by signal-transduction and gene-expression changes identifying which remains a crucial challenge. The EGF-CFC family member Cryptic, that functions as a co-receptor for some TGF-beta ligands, is developmentally expressed in higher mammals and mutations in the gene cause loss or change in left-right axis asymmetry...
October 28, 2016: BMC Developmental Biology
https://www.readbyqxmd.com/read/27784267/expression-of-ribosomopathy-genes-during-xenopus-tropicalis-embryogenesis
#17
Andrew Robson, Nick D L Owens, Susan J Baserga, Mustafa K Khokha, John N Griffin
BACKGROUND: Because ribosomes are ubiquitously required for protein production, it was long assumed that any inherited defect in ribosome manufacture would be embryonically lethal. However, several human congenital diseases have been found to be associated with mutations in ribosome biogenesis factors. Surprisingly, despite the global requirement for ribosomes, these "ribosomopathies" are characterized by distinct and tissue specific phenotypes. The reasons for such tissue proclivity in ribosomopathies remain mysterious but may include differential expression of ribosome biogenesis factors in distinct tissues...
October 26, 2016: BMC Developmental Biology
https://www.readbyqxmd.com/read/27756203/mice-lacking-the-conserved-transcription-factor-grainyhead-like-3-grhl3-display-increased-apposition-of-the-frontal-and-parietal-bones-during-embryonic-development
#18
Stephen J Goldie, Benedicta D Arhatari, Peter Anderson, Alana Auden, Darren D Partridge, Stephen M Jane, Sebastian Dworkin
BACKGROUND: Increased apposition of the frontal and parietal bones of the skull during embryogenesis may be a risk factor for the subsequent development of premature skull fusion, or craniosynostosis. Human craniosynostosis is a prevalent, and often serious embryological and neonatal pathology. Other than known mutations in a small number of contributing genes, the aetiology of craniosynostosis is largely unknown. Therefore, the identification of novel genes which contribute to normal skull patterning, morphology and premature suture apposition is imperative, in order to fully understand the genetic regulation of cranial development...
October 18, 2016: BMC Developmental Biology
https://www.readbyqxmd.com/read/27737629/lack-of-effects-of-ooplasm-transfer-on-early-development-of-interspecies-somatic-cell-nuclear-transfer-bison-embryos
#19
L Antonio González-Grajales, Laura A Favetta, W Allan King, Gabriela F Mastromonaco
BACKGROUND: Successful development of iSCNT (interspecies somatic cell nuclear transfer) embryos depends on complex interactions between ooplasmic and nuclear components, which can be compromised by genetic divergence. Transfer of ooplasm matching the genetic background of the somatic cell in iSCNT embryos is a valuable tool to study the degree of incompatibilities between nuclear and ooplasmic components. This study investigated the effects of ooplasm transfer (OT) on cattle (Bos taurus) and plains bison (Bison bison bison) embryos produced by iSCNT and supplemented with or without ooplasm from cattle or plains bison oocytes...
October 13, 2016: BMC Developmental Biology
https://www.readbyqxmd.com/read/27733125/distinct-shape-shifting-regimes-of-bowl-shaped-cell-sheets-embryonic-inversion-in-the-multicellular-green-alga-pleodorina
#20
Stephanie Höhn, Armin Hallmann
BACKGROUND: The multicellular volvocine alga Pleodorina is intermediate in organismal complexity between its unicellular relative, Chlamydomonas, and its multicellular relative, Volvox, which shows complete division of labor between different cell types. The volvocine green microalgae form a group of genera closely related to the genus Volvox within the order Volvocales (Chlorophyta). Embryos of multicellular volvocine algae consist of a cellular monolayer that, depending on the species, is either bowl-shaped or comprises a sphere...
October 13, 2016: BMC Developmental Biology
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