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Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]

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https://www.readbyqxmd.com/read/29153701/is-distal-pancreatectomy-with-en-bloc-celiac-axis-resection-effective-for-patients-with-locally-advanced-pancreatic-ductal-adenocarcinoma-multicenter-surgical-group-study
#1
Tomohisa Yamamoto, Sohei Satoi, Manabu Kawai, Fuyuhiko Motoi, Masayuki Sho, Ken-Ichiro Uemura, Ippei Matsumoto, Goro Honda, Ken-Ichi Okada, Takahiro Akahori, Hirochika Toyama, Masanao Kurata, Hiroaki Yanagimoto, Hiroki Yamaue, Michiaki Unno, Masanori Kon, Yoshiaki Murakami
OBJECTIVES: We retrospectively investigated the operative outcomes of patients who underwent distal pancreatectomy (DP) for invasive pancreatic ductal adenocarcinoma (PDAC) located at the body and tail. METHODS: Data from 395 patients with PDAC who underwent DP with margin-negative resection (R0 or R1) were collected from seven high-volume centers in Japan from 2001 to 2012. Among them, 72 patients underwent DP with en-bloc celiac axis resection (DP-CAR). The remaining 323 patients underwent conventional DP with splenectomy (DP-S)...
November 14, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29153700/heparanase-expression-in-blood-is-sensitive-to-monitor-response-to-anticancer-treatment-in-pancreatic-cancer-a-pilot-study
#2
Wujun Wu, Lin Zhao, Yongtian Yu, Haitian Hu, Huaiping Shi, Qian'an Jia, Lixue Du
BACKGROUND: /Objectives: High heparanase level was shown in maliganant tumor; however, whether or not heparanase may serve as a sensitive marker to monitor response to anticancer treatment is still unknown. METHODS: In the pilot study, heparanase mRNA expression in peripheral blood mononuclear cell fraction (PBMC) and activity in plasma and urine were detected by quantitative real time RT-PCR and heparan-degrading enzyme assay in 31 pancreatic cancer patients. RESULTS: Heparanase mRNA and activity in samples from cancer patients were significantly higher than that in healthy donors...
November 13, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29146108/pancreatectomy-for-pancreatic-incidentaloma-what-are-the-risks
#3
Morgane Bouquot, Sébastien Gaujoux, François Cauchy, David Birnbaum, Safi Dokmak, Philippe Levy, Olivier Soubrane, Alain Sauvanet
BACKGROUND: Pancreatic incidentalomas (PI) are nowadays common but the benefit-risk balance of surgery remains difficult to determine. METHODS: Monocentric retrospective study of 881 pancreatectomies comparing resected PI with symptomatic lesion. Univariate and multivariate (MV) analyses were done to identify risk factors of malignancy in PI undergoing surgery. RESULTS: Overall, 32% of pancreatectomies were performed for PI. Median size of PI was 30 mm (vs 28 mm; p = 0...
November 7, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29137857/matricellular-proteins-and-survival-in-patients-with-pancreatic-cancer-a-systematic-review
#4
REVIEW
Sirio Fiorino, Maria Letizia Bacchi-Reggiani, Chiara Birtolo, Giorgia Acquaviva, Michela Visani, Adele Fornelli, Michele Masetti, Andrea Tura, Stefano Sbrignadello, Fabio Grizzi, Federica Patrinicola, Matteo Zanello, Laura Mastrangelo, Raffaele Lombardi, Claudia Benini, Luca Di Tommaso, Arrigo Bondi, Francesco Monetti, Elena Siopis, Paolo Emilio Orlandi, Michele Imbriani, Carlo Fabbri, Silvia Giovanelli, Andrea Domanico, Esterita Accogli, Salomone Di Saverio, Daniela Grifoni, Vincenzo Cennamo, Paolo Leandri, Elio Jovine, Dario de Biase
Extracellular matrix (ECM) plays a fundamental role in tissue architecture and homeostasis and modulates cell functions through a complex interaction between cell surface receptors, hormones, several bioeffector molecules, and structural proteins like collagen. These components are secreted into ECM and all together contribute to regulate several cellular activities including differentiation, apoptosis, proliferation, and migration. The so-called "matricellular" proteins (MPs) have recently emerged as important regulators of ECM functions...
November 4, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29111264/management-of-clinically-relevant-postpancreatectomy-hemorrhage-pph-over-two-decades-a-comparative-study-of-1%C3%A2-450-consecutive-patients-undergoing-pancreatic-resection
#5
Steffen Wolk, Robert Grützmann, Nuh N Rahbari, Ralf T Hoffmann, Verena Plodeck, Jürgen Weitz, Thilo Welsch, Marius Distler
BACKGROUND/OBJECTIVES: PPH is the main cause of mortality (up to 50%) after pancreatic resection. Due to differences in time of onset, localization and clinical impairment, there is no consistent management algorithm. METHODS: Between 1994 and 2014 the occurrence of PPH in 115 out of 1 450 patients from a prospectively collected database was analyzed. The cohort was divided into two time periods: 1994-2009 and 2010-2014. The differences between the two groups were analyzed...
October 25, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29050930/a-plea-for-more-practical-and-clinically-applicable-criteria-defining-type-3c-diabetes
#6
EDITORIAL
Geert Roeyen, Christophe De Block
No abstract text is available yet for this article.
October 14, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29066007/point-shear-wave-elastography-in-chronic-pancreatitis-a-promising-tool-for-staging-disease-severity
#7
Roberta Pozzi, Ilaria Parzanese, Alessandra Baccarin, Mariangela Giunta, Clara Benedetta Conti, Paolo Cantù, Giovanni Casazza, Andrea Tenca, Roberto Rosa, Daniele Gridavilla, Giovanni Casella, Dario Conte, Mirella Fraquelli
BACKGROUND: Objectives: ElastPQ(®)-pSWE is an ultrasound technique developed to stage disease severity in patients with chronic liver diseases. Little data is available about its application to the pancreas. We aimed to assess the feasibility and reproducibility of pancreatic stiffness (PS) measurements in patients with chronic pancreatitis and their relationship with clinical and laboratory data. MATERIAL AND METHODS: 52 consecutive patients with chronic pancreatitis (CP) (40 males; median age 60 years) underwent hepatic and pancreatic pSWE...
October 13, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29102149/systemic-histone-release-disrupts-plasmalemma-and-contributes-to-necrosis-in-acute-pancreatitis
#8
Peter Szatmary, Tingting Liu, Simon T Abrams, Svetlana Voronina, Li Wen, Michael Chvanov, Wei Huang, Guozheng Wang, David N Criddle, Alexey V Tepikin, Cheng-Hock Toh, Robert Sutton
BACKGROUND: Clinical and experimental acute pancreatitis feature histone release within the pancreas from innate immune cells and acinar cell necrosis. In this study, we aimed to detail the source of circulating histones and assess their role in the pathogenesis of acute pancreatitis. METHODS: Circulating nucleosomes were measured in patient plasma, taken within 24 and 48 h of onset of acute pancreatitis and correlated with clinical outcomes. Using caerulein hyperstimulation, circulating histones were measured in portal, systemic venous and systemic arterial circulation in mice, and the effects of systemic administration of histones in this model were assessed...
October 7, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29030078/evaluation-of-the-prognostic-value-of-neutrophil-to-lymphocyte-ratio-in-patients-with-hypertriglyceridemia-induced-acute-pancreatitis
#9
Yuchen Wang, Harry E Fuentes, Bashar M Attar, Palash Jaiswal, Melchor Demetria
INTRODUCTION: Recent studies attribute promising prognostic values to various inflammatory biomarkers in acute pancreatitis, including the following: the neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and red cell distribution width (RDW). We aimed to determine the performance of these biomarkers for detecting disease severity in patients with hypertriglyceridemia-induced acute pancreatitis (HTG-AP). METHODS: We retrospectively reviewed 110 patients with HTG-AP and compared the NLR, PLR, and RDW in different severity groups...
October 6, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29066391/gastrojejunostomy-versus-duodenal-stent-placement-for-gastric-outlet-obstruction-in-patients-with-unresectable-pancreatic-cancer
#10
Yukio Yoshida, Akira Fukutomi, Masaki Tanaka, Teiichi Sugiura, Noboru Kawata, Sadayuki Kawai, Yosuke Kito, Satoshi Hamauchi, Takahiro Tsushima, Tomoya Yokota, Akiko Todaka, Nozomu Machida, Kentaro Yamazaki, Yusuke Onozawa, Hirofumi Yasui
BACKGROUND/OBJECTIVE: Whether gastrojejunostomy (GJJ) or duodenal stent (DS) placement is preferable for treatment of gastric outlet obstruction (GOO) in patients with unresectable pancreatic cancer is unclear. We compared the usefulness of GJJ with that of DS placement in these patients. METHODS: We retrospectively reviewed 66 consecutive patients with unresectable pancreatic cancer who underwent GJJ or DS placement for symptomatic GOO. RESULTS: We analyzed 30 patients who underwent GJJ and 23 who underwent DS placement...
October 3, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29033011/usefulness-of-positron-emission-tomography-pet-contrast-enhanced-computed-tomography-ce-ct-in-discriminating-between-malignant-and-benign-intraductal-papillary-mucinous-neoplasms-ipmns
#11
Koji Ohta, Minoru Tanada, Yoshifumi Sugawara, Norihiro Teramoto, Haruo Iguchi
BACKGROUND/OBJECTIVES: We evaluated the usefulness of positron emission tomography (PET)/contrast-enhanced computed tomography (CE-CT) in discriminating between malignant and benign intraductal papillary mucinous neoplasms (IPMNs). METHODS: PET/CE-CT imaging was conducted on 29 IPMN lesions, which subsequently underwent surgery. Preoperative findings on PET/CE-CT imaging were compared with the histological findings of the resected specimens to determine the diagnostic accuracy of PET/CE-CT imaging for evaluation of the differential diagnosis between benign and malignant IPMNs...
October 3, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29037917/immunomodulation-after-radiofrequency-ablation-of-locally-advanced-pancreatic-cancer-by-monitoring-the-immune-response-in-10-patients
#12
Alessandro Giardino, Giulio Innamorati, Stefano Ugel, Omar Perbellini, Roberto Girelli, Isabella Frigerio, Paolo Regi, Filippo Scopelliti, Giovanni Butturini, Salvatore Paiella, Matilde Bacchion, Claudio Bassi
OBJECTIVE/BACKGROUND: RFA of pancreatic cancer has been demonstrated to be feasible and safe with a positive impact on survival. The aim was to investigate whether an immune reaction is activated after locally advanced pancreatic cancer (LAPC) ablation. METHODS: Peripheral Blood samples were obtained preoperatively and on post-operative days 3-30. Evaluated parameters were: cells [CD4(+), CD8(+) and activated subsets, T-Reg, Monocytes, myeloid and plasmocytoid Dendritic cells (mDC and pDC)] and cytokines [Interleukin (IL)-6, Stromal-cells derived factor (SDF)-1, IL-1β, Tumour-Necrosis Factor (TNF)-α, Interferon (IFN)-γ, Vascular Endothelial Growth Factor (VEGF), chemokine (C-C motif) ligand 5 (CCL-5), Transforming-Growth Factor (TGF)-β]...
September 27, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28988600/an-evaluation-study-of-reported-pancreatic-adenocarcinoma-risk-associated-snps-from-genome-wide-association-studies-in-chinese-population
#13
Xiaoyi Wang, Xiaoling Lin, Rong Na, Deke Jiang, Pengyin Zhang, Ji Li, Chen Jin, Deliang Fu, Jianfeng Xu
BACKGROUND: Previous genome-wide association studies (GWAS), and a pathway study of pancreatic ductal adenocarcinoma (PDAC) identified 14 significantly associated single nucleotide polymorphisms (SNPs) along with another 7 promising loci in European, Japanese, and Chinese descents. In this study, we aimed to evaluate the potential association of these SNPs with PDAC risk in the Chinese population. METHODS: In this Chinese population-based case-control study with 254 cases and 1200 controls, we tested 20 PDAC risk associated SNPs from previous GWAS and one SNP from a pathway-based study...
September 27, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28958690/relationship-between-circulating-levels-of-pancreatic-proteolytic-enzymes-and-pancreatic-hormones
#14
Sakina H Bharmal, Sayali A Pendharkar, Ruma G Singh, Mark O Goodarzi, Stephen J Pandol, Maxim S Petrov
BACKGROUND: While the close morphological relationship between the exocrine and endocrine pancreas is well established, their functional interaction remains poorly understood. The aim of this study was to investigate the associations between circulating levels of pancreatic proteolytic enzymes and insulin, as well as other pancreatic hormones. METHODS: Fasting venous blood samples were collected and analyzed for trypsin, chymotrypsin, insulin, glucagon, somatostatin, and pancreatic polypeptide...
September 20, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28939443/chronic-pancreatitis-in-patients-with-liver-cirrhosis-negatively-affects-graft-survival-after-liver-transplantation
#15
Malte H Wehmeyer, Werner Dammermann, Oliver Seiz, Madeleine E Zinser, Antonio Galante, Ansgar W Lohse, Martina Sterneck, Björn Nashan, Uta Herden, Stefan Lüth
BACKGROUND: Limited data exists concerning the coincidence of chronic pancreatitis (CP) and liver cirrhosis with respect to the patient outcome after liver transplantation (LT). The aim of the study was to identify risk factors for graft loss after liver transplantation and to evaluate the impact of CP on graft survival. METHODS: We analyzed the data of 421 cirrhotic patients who underwent evaluation for primary liver transplantation from January 2007 to January 2014...
September 14, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29054814/laparoscopic-management-of-solid-pseudo-papillary-neoplasm-of-pancreas-in-tertiary-care-center-from-south-india
#16
Palanisamy Senthilnathan, Kailash Chandra Dhaker, Vivek Kaje, Subrahmaneswara Babu Naidu, M Sarvani, Sandeep C Sabnis, Sivakumar Srivatsan Gurumurthy, V P Nalakilli, Natesan Anand Vijay, Subbaiah Rajapandian, Palanivelu Praveen Raj, Ramakrishnan Parthasarathi, Chinnusamy Palanivelu
BACKGROUND: Solid pseudo papillary neoplasm (SPN) of the pancreas which predominantly affects young women is a relatively indolent entity with favorable prognosis. Resection through minimal access approach helps to achieve better short term benefits. The aim of this study is to describe our experience in laparoscopic management of this disease. METHODS: A retrospective review of our prospectively maintained database revealed that 17 patients with SPN were managed with surgical resection between March 2009 and October 2016...
September 11, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28958898/the-impact-of-pancreaticoduodenectomy-on-endocrine-and-exocrine-pancreatic-function-a-prospective-cohort-study-based-on-pre-and-postoperative-function-tests
#17
Geert Roeyen, Miet Jansen, Vera Hartman, Thiery Chapelle, Bart Bracke, Dirk Ysebaert, Christophe De Block
BACKGROUND/OBJECTIVES: Studies reporting on function after pancreatic surgery are frequently based on diabetes history, fasting glycemia or random glycemia. The aim of this study was to investigate prospectively the evolution of pancreatic function in patients undergoing pancreaticoduodenectomy based on proper pre- and postoperative function tests. It was hypothesised that pancreatic function deteriorates after pancreaticoduodenectomy. METHODS: Between 2013 and 2016, 78 patients undergoing pancreaticoduodenectomy for oncologic indications had a prospective evaluation of their endocrine and exocrine pancreatic function...
September 9, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28890154/diabetes-mellitus-in-intraductal-papillary-mucinous-neoplasm-of-the-pancreas-is-associated-with-high-grade-dysplasia-and-invasive-carcinoma
#18
Vicente Morales-Oyarvide, Mari Mino-Kenudson, Cristina R Ferrone, Dushyant V Sahani, Ilaria Pergolini, Adrián A Negreros-Osuna, Andrew L Warshaw, Keith D Lillemoe, Carlos Fernández-Del Castillo
BACKGROUND: While the association between Diabetes Mellitus (DM) and pancreatic ductal adenocarcinoma is well recognized, its importance in intraductal papillary mucinous neoplasm of the pancreas (IPMN) is not well-defined. We sought to examine the associations of DM with degree of dysplasia and morphological subtypes in IPMN. METHODS: In 454 patients with resected IPMN, we evaluated associations of DM with high-grade dysplasia (HGD), invasive carcinoma, precursor epithelial subtype (gastric, intestinal, oncocytic, pancreatobiliary), and histological type of invasive carcinomas (tubular, colloid, oncocytic) using logistic regression...
September 7, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28935288/the-potential-role-of-gut-microbiota-in-pancreatic-disease-a-systematic-review
#19
REVIEW
Robert Memba, Sinead N Duggan, Hazel M Ni Chonchubhair, Oonagh M Griffin, Yasir Bashir, Donal B O'Connor, Anne Murphy, Jean McMahon, Yuri Volcov, Barbara M Ryan, Kevin C Conlon
BACKGROUND: Several studies have suggested a link between microbiota imbalance and some gastrointestinal, inflammatory and neoplastic diseases. However, the role in pancreatic diseases remain unclear. To evaluate the available evidence for pancreatic diseases, we undertook a systematic review. METHODS: OVID Medline (1946-2017), EMBASE (1980-2017) and the Cochrane Central Register of Controlled Trials (CENTRAL Issue 3, 2017) were searched for studies on microbiota in pancreatic disease...
September 6, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29129384/radiofrequency-ablation-for-hepatic-oligometastatic-pancreatic-cancer-an-analysis-of-safety-and-efficacy
#20
Yong-Qiang Hua, Peng Wang, Xiao-Yan Zhu, Ye-Hua Shen, Kun Wang, Wei-Dong Shi, Jun-Hua Lin, Zhi-Qiang Meng, Zhen Chen, Hao Chen
OBJECTIVES: This study was to evaluate the value of radiofrequency ablation (RFA) in the treatment of pancreatic cancer with synchronous liver oligometastasis. METHODS: 102 patients diagnosed with pancreatic cancer with synchronous liver oligometastasis undergoing RFA were recruited in this retrospective study between January 2012 and December 2015. Clinical efficacy was evaluated by computed tomography or magnetic resonance imaging 1 month later. All patients were treated with RFA and systemic chemotherapy based on NCCN guideline...
September 1, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
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