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Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]

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https://www.readbyqxmd.com/read/29449151/multiphase-evaluation-of-contrast-enhanced-endoscopic-ultrasonography-in-the-diagnosis-of-pancreatic-solid-lesions
#1
Takuya Ishikawa, Yoshiki Hirooka, Hiroki Kawashima, Eizaburo Ohno, Kiyotaka Hashizume, Kohei Funasaka, Masanao Nakamura, Ryoji Miyahara, Osamu Watanabe, Masatoshi Ishigami, Hidemi Goto
BACKGROUND/OBJECTIVES: Time-intensity curve (TIC) under contrast-enhanced EUS (CE-EUS) allows continuous and quantitative evaluation of targeted area in the pancreas. However, TIC is not always available and the procedure is complicated. We aimed to propose a simplified method by evaluating multiple phases of CE-EUS in the diagnosis of pancreatic solid lesions. METHODS: We retrospectively reviewed 210 patients with pancreatic solid lesions including 142 with pancreatic ductal cancer (PDAC), 31 with pancreatic neuroendocrine neoplasm, 13 with solid pseudopapillary neoplasm and 24 with mass-forming pancreatitis who underwent CE-EUS and achieved final diagnoses...
February 9, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29452754/insulinoma-a-retrospective-study-analyzing-the-differences-between-benign-and-malignant-tumors
#2
A B Câmara-de-Souza, M T K Toyoshima, M L Giannella, D S Freire, C P Camacho, D M Lorenço, M S Rocha, T Bacchella, R Jureidini, M C C Machado, M Q Almeida, M A A Pereira
BACKGROUND/OBJECTIVES: Insulinoma is a rare pancreatic tumor and, usually, a benign disease but can be a malignant one and, sometimes, a highly aggressive disease. The aim of this study was to determine differences between benign and malignant tumors. METHODS: Retrospective study of 103 patients with insulinoma treated in a tertiary center. It was analyzed demographic, clinical, laboratory, localization and histologic analysis of tumor and follow up data of subjects in order to identify differences between individuals benign and malignant disease...
February 1, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29422392/the-immune-imbalance-in-the-second-hit-of-pancreatitis-is-independent-of-il-17a
#3
John-Edwin Thomson, Martin Brand, Pascaline Fonteh
BACKGROUND: Severe acute pancreatitis (SAP) is characterised by two distinct clinical phases. Organ dysfunction and death is initially as a result of a systemic inflammatory response syndrome (SIRS). Systemic sepsis from infected pancreatic necrosis characterises the second phase, the so called 'second hit' of acute pancreatitis (AP). An immune imbalance during the second hit is postulated to contribute to the formation of the septic complications that occur in these patients. The pro-inflammatory T-helper (Th) 17 pathway has been shown to be an initiator of early SIRS in AP, however to date its role has not been established in the second hit in AP...
January 31, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29395620/high-throughput-gene-sequencing-reveals-altered-landscape-in-dna-damage-responses-and-chromatin-remodeling-in-sporadic-pancreatic-neuroendocrine-tumors
#4
Shunrong Ji, Wenting Yang, Jiang Liu, Jingjing Zhao, Liang Chen, Quanxing Ni, Jiang Long, Xianjun Yu
PURPOSE: The main objectives of this retrospective study were to survey the genetic landscape of PNETs in a clinical cohort by using the high throughput gene sequencing method and to determine cellular signaling networks affected by the uncovered gene mutations. MATERIALS AND METHODS: We retrieved the demographics and tumor characteristics of 13 patients. Cellular DNA was extracted from fresh snap frozen tumor tissues and was subject to high throughput gene sequencing analysis using the Illumina NextSeq500 System...
January 30, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29395619/development-and-validation-of-a-multivariate-prediction-model-for-patients-with-acute-pancreatitis-in-intensive-care-medicine
#5
Felix Zubia-Olaskoaga, Enrique Maraví-Poma, Iratxe Urreta-Barallobre, María-Rosario Ramírez-Puerta, Mónica Mourelo-Fariña, María-Pilar Marcos-Neira, Miguel Ángel García-García
BACKGROUND/OBJECTIVES: Development and validation of a multivariate prediction model for patients with acute pancreatitis (AP) admitted in Intensive Care Units (ICU). METHODS: A prospective multicenter observational study, in 1 year period, in 46 international ICUs (EPAMI study). PATIENTS: adults admitted to an ICU with AP and at least one organ failure. INTERVENTIONS: Development of a multivariate prediction model, using the worst data of the stay in ICU, based in multivariate analysis, simple imputation in a development cohort...
January 29, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29361429/sunitinib-in-patients-with-pre-treated-pancreatic-neuroendocrine-tumors-a-real-world-study
#6
Maria Rinzivillo, Nicola Fazio, Sara Pusceddu, Andrea Spallanzani, Toni Ibrahim, Davide Campana, Riccardo Marconicini, Stefano Partelli, Giuseppe Badalamenti, Maria Pia Brizzi, Laura Catena, Giovanni Schinzari, Carlo Carnaghi, Rossana Berardi, Antongiulio Faggiano, Lorenzo Antonuzzo, Francesca Spada, Sara Gritti, Daniela Femia, Fabio Gelsomino, Alberto Bongiovanni, Sergio Ricci, Nicole Brighi, Massimo Falconi, Gianfranco Delle Fave, Francesco Panzuto
INTRODUCTION: Besides data reported in a Phase-III trial, data on sunitinib in pancreatic Neuroendocrine Tumors (panNETs) are scanty. AIM: To evaluate sunitinib efficacy and tolerability in panNETs patients treated in a real-world setting. PATIENTS AND METHODS: Retrospective analysis of progressive panNETs treated with sunitinib. Efficacy was assessed by evaluating progression-free survival, overall survival, and disease control (DC) rate (stable disease (SD) + partial response + complete response)...
January 12, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29338920/endoscopic-ultrasound-guided-22-gauge-core-needle-biopsy-for-the-diagnosis-of-autoimmune-pancreatitis
#7
LETTER
Abhik Bhattacharya, Michael Cruise, Prabhleen Chahal
BACKGROUND: It is difficult to obtain adequate tissue sample for diagnosing autoimmune pancreatitis (AIP) with the help of traditional EUS-guided FNA. As per ICDC guidelines, EUS-guided FNA is not recommended for diagnosing AIP(1). We herein present a report of 2 cases of using a new flexible 22 gauge (G) core biopsy needle (SharkCore, Medtronic, Sunnydale, Calif) for diagnosing AIP. METHODS: This is a report of 2 cases reviewed retrospectively which had used 22G core biopsy needle for obtaining histo-pathological samples for diagnosing AIP...
January 10, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29398347/epc-hpsg-evidence-based-guidelines-for-the-management-of-pediatric-pancreatitis
#8
REVIEW
Andrea Párniczky, Maisam Abu-El-Haija, Sohail Husain, Mark Lowe, Grzegorz Oracz, Miklós Sahin-Tóth, Flóra K Szabó, Aliye Uc, Michael Wilschanski, Heiko Witt, László Czakó, Tassos Grammatikopoulos, Ib Christian Rasmussen, Robert Sutton, Péter Hegyi
BACKGROUND: Pediatric pancreatitis is an underdiagnosed disease with variable etiology. In the past 10-15 years the incidence of pediatric pancreatitis has increased, it is now 3.6-13.3 cases per 100,000 children. Up-to-date evidence based management guidelines are lacking for the pediatric pancreatitis. The European Pancreatic Club, in collaboration with the Hungarian Pancreatic Study Group organized a consensus guideline meeting on the diagnosis and management of pancreatitis in the pediatric population...
January 4, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29338919/agreement-among-magnetic-resonance-imaging-magnetic-resonance-cholangiopancreatography-mri-mrcp-and-endoscopic-ultrasound-eus-in-the-evaluation-of-morphological-features-of-branch-duct-intraductal-papillary-mucinous-neoplasm-bd-ipmn
#9
Laura Uribarri-Gonzalez, Margaret G Keane, Stephen P Pereira, Julio Iglesias-García, J Enrique Dominguez-Muñoz, Jose Lariño-Noia
BACKGROUND/OBJECTIVES: To evaluate the agreement between the imaging modalities MRI-MRCP and EUS in cystic lesions of the pancreas which were thought to be a BD-IPMN. METHODS: Multicenter retrospective study included all patients between 2010 and 2015 with a suspected BD-IPMN who underwent an EUS and MRI-MRCP within 6 months or less of each other. Location, number, size, worrisome features and high-risk stigmata were evaluated. Interobserver agreement was evaluated by Kappa score...
January 4, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29325893/stilamin-inhibits-intestinal-and-pancreatic-injury-in-rats-with-severe-acute-pancreatitis-by-down-regulating-lcn2-expression
#10
Yifan Ren, Qing Cui, Jianbin Bi, Zhaoqing Du, Jia Zhang, Xufeng Zhang, Yi Lv, Rongqian Wu
OBJECTIVE: This study was aimed at exploring the function and mechanism of Stilamin on severe acute pancreatitis (SAP) in rats. METHODS: We analyzed the histology of small intestine and pancreatic tissues of SAP rats and SAP rats plus treatment with Stilamin. The expression levels of IL-6 and TNF-α in serum were detected using ELISA. The expressions of Caspase-3, bcl-2, Bax and p53 in rat tissues of SAP group were verified by qRT-PCR and western blot. The differential expressed mRNAs in rats of SAP group were screened out by microarray analysis...
January 2, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29305088/immunohistochemical-analysis-of-imp3-and-p53-expression-in-endoscopic-ultrasound-guided-fine-needle-aspiration-and-resected-specimens-of-pancreatic-diseases
#11
Junichi Senoo, Rintaro Mikata, Takashi Kishimoto, Masahiro Hayashi, Yuko Kusakabe, Shin Yasui, Mutsumi Yamato, Hiroshi Ohyama, Harutoshi Sugiyama, Toshio Tsuyuguchi, Hideyuki Yoshitomi, Masayuki Ohtsuka, Juri Maeda, Satoshi Ota, Yukio Nakatani, Naoya Kato
BACKGROUND: Insulin-like growth factor II messenger ribonucleic acid-binding protein 3 (IMP3) is a valuable marker that distinguishes malignant from benign lesions and predicts prognosis. METHODS: First, we evaluated IMP3 expression in 77 resected specimens of pancreatic ductal adenocarcinoma (PDAC), intraductal papillary mucinous neoplasm (IPMN), and chronic pancreatitis (CP). Eleven PDAC patients preoperatively underwent endoscopic ultrasound-guided fine needle aspiration (EUS-FNA)...
December 26, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29295776/the-high-stromal-sparc-expression-is-independently-associated-with-poor-survival-of-patients-with-resected-pancreatic-ductal-adenocarcinoma-treated-with-adjuvant-gemcitabine-in-combination-with-s-1-or-adjuvant-gemcitabine-alone
#12
Ryuta Shintakuya, Naru Kondo, Yoshiaki Murakami, Kenichiro Uemura, Naoya Nakagawa, Keisuke Okano, Shinya Takahashi, Taijiro Sueda
BACKGROUND: Although postoperative adjuvant chemotherapy for pancreatic ductal adenocarcinoma (PDAC) improves survival, its efficacy varies among individuals. Identification of biomarkers that can predict the efficacy of adjuvant chemotherapy for PDAC is essential. OBJECTIVES: To investigate the predictive value of secreted protein acidic and rich in cysteine (SPARC) expression in patients with PDAC treated with adjuvant gemcitabine in combination with S-1 (adjuvant GS) or adjuvant gemcitabine alone (adjuvant G alone)...
December 26, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29289465/investigating-the-role-of-transcription-factors-of-pancreas-development-in-pancreatic-cancer
#13
REVIEW
Ahmad Abu Turab Naqvi, Gulam Mustafa Hasan, Md Imtaiyaz Hassan
Pancreatic cancer (PC) is the seventh most common cause of cancer-related deaths worldwide that kills more than 300,000 people every year. Prognosis of PC is very poor with a five-year survival rate about 5%. The most common and highly observed type of PC is pancreatic ductal adenocarcinoma (PDAC). It is preceded by the progression of precursor lesions such as Pancreatic Intraepithelial Neoplasia (PanIN), Intraductal Papillary Neoplasm (IPMN) and Mucinous Cystic Neoplasm (MCN). PanIN is the most common among these premalignant lesions...
December 24, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29289464/kinetics-of-pancreatic-tissue-proliferation-in-a-polymeric-platform-in-mice
#14
Luciana Xavier Pereira, Celso Tarso Rodrigues Viana, Laura Alejandra Ariza Orellano, Simone Aparecida de Almeida, Marcela Guimarães Takahashi de Lazari, Letícia Chinait Couto, Anilton Cesar Vasconcelos, Silvia Passos Andrade, Paula Peixoto Campos
BACKGROUND/OBJECTIVES: Pancreas regenerative capacity after injury is not always sufficient to comply with the body's requirement of digestive enzymes and hormones. We present an alternative system to induce pancreas parenchyma proliferation (exocrine and endocrine components), rather than regeneration or remodeling in normoglycemic mice. METHODS: Porous discs of polyether-polyurethane were surgically placed adjacent to the native pancreas and removed at days 15, 30 and 45 after implantation...
December 21, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29331217/the-cost-of-perioperative-complications-following-pancreaticoduodenectomy-a-systematic-review
#15
REVIEW
Jason Wang, Ronald Ma, Leonid Churilov, Paul Eleftheriou, Mehrdad Nikfarjam, Christopher Christophi, Laurence Weinberg
BACKGROUND/OBJECTIVES: Pancreaticoduodenectomy (PD), also known as a Whipple procedure, is commonly performed for a variety of benign and malignant tumours, including of the pancreatic head and surrounding structures. PD is associated with low mortality but high morbidity and costs. Our objective was to describe the financial burden of complications following pancreaticoduodenectomy. METHODS: We searched for articles using the MEDLINE, EMBASE, Cochrane and EconLit databases from the year 2000...
December 19, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29277262/pancreatectomies-for-pancreatic-neoplasms-in-pediatric-and-adolescent-age-a-single-institution-experience
#16
Chiara Scandavini, Roberto Valente, Elena Rangelova, Ralf Segersvärd, Urban Arnelo, Johan Permert, Pär-Johan Svensson, Jakob Stenman, Marco Del Chiaro
BACKGROUND: There are very few data in the current literature regarding the short- and long-term outcome of surgery for pediatric pancreatic tumors (PPT). No data are available on the impact of pancreatic surgery on the children's growth. METHODS: This is a retrospective cohort study on a consecutive series of pediatric/adolescent patients who underwent pediatric surgery at Karolinska University Hospital from January 2005 to July 2017. RESULTS: Overall 14 pancreatic operations were performed in 13 patients...
December 19, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29269290/pancreatic-inflammation-and-atrophy-are-not-associated-with-pancreatic-cancer-concomitant-with-intraductal-papillary-mucinous-neoplasm
#17
Yosuke Yagi, Atsuhiro Masuda, Yoh Zen, Hideyuki Shiomi, Hirochika Toyama, Keitaro Sofue, Mamoru Takenaka, Takashi Kobayashi, Takashi Nakagawa, Kodai Yamanaka, Takuya Ikegawa, Namiko Hoshi, Masaru Yoshida, Yoshifumi Arisaka, Yoshihiro Okabe, Hiromu Kutsumi, Takumi Fukumoto, Yonson Ku, Takeshi Azuma
BACKGROUND: Inflammation-induced carcinogenesis in pancreatic ductal adenocarcinoma (PDAC) has been reported; however, its involvement in PDAC with intraductal papillary mucinous neoplasm (IPMN) remains unclear. We herein investigated the relationship between pancreatic atrophy and inflammation and the incidence of PDAC concomitant with IPMN. METHODS: This study included 178 consecutive patients who underwent surgical resection for PDAC with IPMN (N = 21) and IPMN (N = 157) between April 2001 and October 2016...
December 16, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29433805/proactive-multi-modality-treatment-of-pancreatic-neuroendocrine-tumours-pnets-potential-survival-benefits
#18
L Tanno, D Mayo, S Mills, A Takhar, J Cave, L Nolan, B Stedman, F X Sundram, M Abu Hilal, H Connor, N Pearce, T Armstrong
BACKGROUND/OBJECTIVES: Primary and metastatic pancreatic neuroendocrine tumours (PNET) can be treated with combination of surgery, locoregional and systemic therapy. Survival benefits from individual treatments have been well reported, however, the combined outcome from multimodal treatments are not well described in the literature. We report outcomes in a cohort of PNET patients treated with proactive, multimodality therapy. METHODS: 106 patients were identified from a single tertiary referral centre prospective database...
December 14, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29305087/few-comments-on-laparoscopic-management-of-solid-pseudo-papillary-neoplasm-of-pancreas-in-tertiary-care-center-from-south-india
#19
LETTER
Jing Zeng, Rong Deng
No abstract text is available yet for this article.
December 9, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29274720/clinical-significance-of-defining-borderline-resectable-pancreatic-cancer
#20
REVIEW
Mee Joo Kang, Jin-Young Jang, Wooil Kwon, Sun-Whe Kim
Since the introduction of the concept of borderline resectable pancreatic cancer (BRPC), various definitions of this disease entity have been suggested. However, there are several obstacles in defining this disease category. The current diagnostic criteria of BRPC mainly focuses on its expanded 'technical resectability'; however, they are difficult to interpret because of their ambiguity using potential subjective or arbitrary terminology, In addition, limitations in current imaging technology and a lack of evidence in radiological-pathological-clinical correlation make it difficult to refine the criteria...
December 9, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
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