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Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]

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https://www.readbyqxmd.com/read/28215485/association-of-igg4-response-and-autoimmune-pancreatitis-with-intraductal-papillary-mucinous-neoplasms
#1
Amin A Hedayat, Mikhail Lisovsky, Arief A Suriawinata, Daniel S Longnecker
OBJECTIVES: Concurrent intraductal papillary-mucinous neoplasm (IPMN) and autoimmune pancreatitis (AIP) was observed in a patient (index case) at our institution. Cases of coincidental IPMN and type 1 AIP and concurrent ductal adenocarcinoma (PDAC) and AIP have been previously reported. In this study we evaluate the hypothesis that IPMN elicits an IgG4 response. METHODS: Twenty-one pancreases (including the index case) with IPMN resected at our institution were studied...
February 8, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28215484/establishment-and-characterization-of-a-new-human-acinar-cell-carcinoma-cell-line-faraz-icr-from-pancreas
#2
Marzieh Rezaei, Ahmad Hosseini, Saman Nikeghbalian, Abbas Ghaderi
OBJECTIVES: Basic research in the field of acinar cell carcinoma (ACC) as a rare neoplasm of the pancreas is dependent on the availability of pragmatic model such as new pancreatic cancer cell lines. Thus, establishment and characterization of new pancreatic cancer cell lines from ACC origin are deemed important. METHODS: Faraz-ICR cell line was derived from a 58-years old woman with pancreatic acinar cell carcinoma by the collagenase digestion protocol. We characterized the cell line by examining its morphology and cytostructural and functional profile...
February 8, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28202234/endoscopic-ultrasound-guided-transmural-drainage-of-walled-off-pancreatic-necrosis-using-a-step-up-approach-a-single-centre-experience
#3
Surinder S Rana, Vishal Sharma, Ravi Sharma, Rajesh Gupta, Deepak K Bhasin
BACKGROUND: Walled off necrosis (WON) can be treated endoscopically using multiple transmural plastic stents or fully covered self-expandable metallic stent (FCSEMS) and direct endoscopic necrosectomy (DEN). We evaluated the efficacy of "step-up" endoscopic transmural approach for treatment of WON. METHODS: Retrospective analysis of data of 86 patients with WON who were treated with attempted endoscopic ultrasound (EUS) guided "step up" transmural drainage during last 5 years was done...
February 8, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28190685/impact-of-body-fat-and-muscle-distribution-on-severity-of-acute-pancreatitis
#4
Seung Bae Yoon, Moon Hyung Choi, In Seok Lee, Chul-Hyun Lim, Jin Soo Kim, Yu Kyung Cho, Jae Myung Park, Bo-In Lee, Young-Seok Cho, Myung-Gyu Choi
BACKGROUND/OBJECTIVES: Obesity is a well-established risk factor for severe acute pancreatitis (AP); however, the impact of visceral obesity or sarcopenic obesity on severity of AP has not been well studied. We compared the relationship between severity of AP and various body parameters including body weight, body mass index (BMI), subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), and visceral fat-to-muscle ratio (VMR). METHODS: We analyzed the data of patients who were diagnosed with AP from 2009 to 2015...
February 6, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28190684/analysis-of-amylase-in-duodenal-juice-automated-kinetic-spectrophotometric-analysis-versus-manual-colorimetric-endpoint-assay
#5
Friedemann Erchinger, Trond Engjom, Erling Tjora, Lage Aksnes, Georg Dimcevskir, Oddrun Anita Gudbrandsen
OBJECTIVE: The measurement of duodenal amylase by a colorimetric end-point assay has been the most used method for amylase activity analyses. The method is manual, time consuming and dependent on specialized equipment. In this study, we compare an automated kinetic spectrophotometric method for pancreatic amylase measurement in duodenal juice with a standardized colorimetric end-point assay. METHODS: We used specimen of duodenal juice at random from a biobank obtained by short endoscopic secretin test in patients with suspected exocrine pancreatic failure of different reasons...
February 4, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28209258/biliary-tract-external-drainage-protects-against-multiple-organs-injuries-of-severe-acute-pancreatitis-rats-via-heme-oxygenase-1-upregulation
#6
Jin-Long Wang, Ying Chen, Xiao-Qing Song, Mei-Ling Lu, Bing Zhao, Li Ma, Er-Zhen Chen, En-Qiang Mao
OBJECTIVE: To investigate the effect of biliary tract external drainage (BTED) on severe acute pancreatitis (SAP) in rats and the relationship with heme oxygenase-1 (HO-1) pathway. METHODS: Thirty SD rats weighing 250-300 g were randomly assigned into five groups (n = 6): sham surgery (SS) group, SAP group, SAP + BTED group, SAP + zinc protoporphyrin IX (ZnPP) group, SAP + BTED + ZnPP group. The SAP model was induced via retrograde injection of 4% sodium taurocholate (1 mL/kg) into biliopancreatic duct through duodenal wall...
February 1, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28202235/stx12-lncrna-mir-148a-smad5-participate-in-the-regulation-of-pancreatic-stellate-cell-activation-through-a-mechanism-involving-competing-endogenous-rna
#7
Hao Wang, Yanfeng Jiang, Ming Lu, Bei Sun, Xin Qiao, Dongbo Xue, Weihui Zhang
BACKGROUND: With the deepening of research, the roles of LncRNAs play in the fibrotic process have attracted great attention. At the early stage of pancreatic fibrogenesis, to effectively regulate pancreatic stellate cells (PSCs) activation is crucial for the treatment of chronic pancreatic fibrosis. METHODS: Microarray data on chronic pancreatitis were retrieved from the Gene Expression Omnibus (GEO) repository and analyzed using bioinformatic methods. A diagram of the lncRNA-miRNA-mRNA ceRNA network was constructed...
February 1, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28189431/the-sendai-and-fukuoka-consensus-criteria-for-the-management-of-branch-duct-ipmn-a-meta-analysis-on-their-accuracy
#8
REVIEW
Max Heckler, Christoph W Michalski, Susanne Schaefle, Jörg Kaiser, Markus W Büchler, Thilo Hackert
INTRODUCTION: The risk of malignancy in branch duct intraductal papillary mucinous neoplasia of the pancreas (BD-IPMN) is controversially debated. An increasing number of studies report on outcomes using the Sendai or Fukuoka consensus criteria for treatment decision-making. The objective of this work was to evaluate the diagnostic accuracy of the Sendai and Fukuoka criteria. METHODS: We systematically reviewed studies on Sendai or Fukuoka criteria-guided management of BD-IPMN...
February 1, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28173980/expression-of-polymeric-immunoglobulin-receptor-and-stromal-activity-in-pancreatic-ductal-adenocarcinoma
#9
Prabhu Arumugam, Satyajit Bhattacharya, Joanne Chin-Aleong, Melania Capaso, Hemant M Kocher
BACKGROUND/OBJECTIVES: Polymeric immunoglobulin receptor (pIgR) traffics Immunoglobulins (IgA and IgM) through epithelial cells in normal mucosae but neither are expressed in the normal pancreas. Recent work from our laboratory suggested pIgR may be upregulated in pancreatic ductal adenocarcinoma (PDAC). Our aim was to assess the role of pIgR in human PDAC. METHODS: pIgR expression was manipulated (siRNA and shRNA) in cell lines to evaluate its subsequent effect on cell behaviour in 2D assays as well as 3D organotypics models...
February 1, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28162928/secretin-stimulated-mri-characterization-of-pancreatic-morphology-and-function-in-patients-with-chronic-pancreatitis
#10
Adnan Madzak, Søren Schou Olesen, Ingfrid Salvesen Haldorsen, Asbjørn Mohr Drewes, Jens Brøndum Frøkjær
BACKGROUND/OBJECTIVES: Chronic pancreatitis (CP) is characterized by abnormal pancreatic morphology and impaired endocrine and exocrine function. However, little is known about the relationship between pancreatic morphology and function, and also the association with the etiology and clinical manifestations of CP. The aim was to explore pancreatic morphology and function with advanced MRI in patients with CP and healthy controls (HC) METHODS: Eighty-two patients with CP and 22 HC were enrolled in the study...
January 27, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28131523/morphological-and-immunobiochemical-analysis-of-the-liver-in-l-arginine-induced-experimental-chronic-pancreatitis
#11
Na Hu, Yicong Shen, Fengyu Liu, Jiuping Wu, Feng Yuan, Liwei Tian, Bo Wu, Guoqing Chen, Jianming Zhang, Jun Wang
BACKGROUND: Clinical evidence indicates that hepatic abnormalities in patients with chronic pancreatitis are not uncommon. Here we aimed to study the possible association between liver and pancreatic damage in a recently described experimental mouse model of CP. METHODS: The severity of the damage to pancreas, liver and other organs was assessed by biochemical markers and histopathology. The methods applied included Hematoxylin Eosin staining, electron microscope examination, biochemical measurements, RT-PCR, ELISA, and the correlations among some of the parameters contributing to these changes were statistically analyzed...
January 21, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28153446/anxiety-depression-and-quality-of-life-in-people-with-pancreatic-cancer-and-their-carers
#12
Monika Janda, Rachel E Neale, Kerenaftali Klein, Dianne L O'Connell, Helen Gooden, David Goldstein, Neil D Merrett, David K Wyld, Ingrid J Rowlands, Vanessa L Beesley
BACKGROUND: People with pancreatic cancer have high levels of anxiety and depression and reduced quality of life (QoL), but few studies have assessed these outcomes for patient-carer dyads. We therefore investigated these issues in an Australian population-based study. METHODS: Patients with pancreatic cancer (n = 136) and many of their carers (n = 84) completed the Hospital Anxiety and Depression Scale (HADS) and Functional Assessment of Cancer Therapy QoL questionnaire at a median of three months after diagnosis...
January 20, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28131524/the-histopathologic-type-predicts-survival-of-patients-with-ampullary-carcinoma-after-resection-a-meta-analysis
#13
Yanming Zhou, Dianqi Li, Lupeng Wu, Xiaoying Si
OBJECTIVES: The results of studies on the prognostic value of histopathologic differentiation of the intestinal and pancreatobiliary types of ampullary carcinoma after resection are conflicting. A meta-analysis was undertaken to investigate this issue. METHODS: A systematic literature search was performed to identify articles published from January 2000 to August 2016. Data were pooled for meta-analysis using Review Manager 5.3. RESULTS: Twenty three retrospective studies involving a total of 2234 patients were identified for inclusion, of whom 1021 (45...
January 20, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28159463/the-incidence-and-aetiology-of-acute-pancreatitis-across-europe
#14
REVIEW
Stephen E Roberts, Sian Morrison-Rees, Ann John, John G Williams, Tim H Brown, David G Samuel
BACKGROUND: Acute pancreatitis is increasingly one of the most important acute gastrointestinal conditions throughout much of the world, although incidence and aetiology varies across countries and regions. This study investigated regional and national patterns in the incidence and aetiology of acute pancreatitis, demographic patterns in incidence and trends over time in incidence across Europe. METHODS: A structured review of acute pancreatitis incidence and aetiology from studies of hospitalised patient case series, cohort studies or other population based studies from 1989 to 2015 and a review of trends in incidence from 1970 to 2015 across all 51 European states...
January 19, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28117219/revised-atlanta-classification-and-determinant-based-classification-which-one-better-at-stratifying-outcomes-of-patients-with-acute-pancreatitis
#15
Jun-Ho Choi, Myung-Hwan Kim, Dong Hui Cho, Dongwook Oh, Hyun Woo Lee, Tae Jun Song, Do Hyun Park, Sang Soo Lee, Dong-Wan Seo, Sung Koo Lee
BACGROUND: Two different severity classifications (revised Atlanta classification [RAC] and determinant-based classification [DBC]) were recently proposed. METHODS: This was a retrospective analysis of a prospective acute pancreatitis (AP) database. This study aims to compare the ability of three classification systems (RAC, DBC, and original Atlanta classification [OAC]) to stratify outcomes of AP and to determine the association between different severity categories and clinical outcomes...
January 17, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28122676/prognostic-impact-of-nodal-statuses-in-patients-with-pancreatic-ductal-adenocarcinoma
#16
Yasunari Fukuda, Tadafumi Asaoka, Sakae Maeda, Naoki Hama, Atsushi Miyamoto, Masaki Mori, Yuichiro Doki, Shoji Nakamori
BACKGROUND: The present study aimed to clarify the prognostic impact of nodal statuses in pancreatic ductal adenocarcinoma (PDAC) after potentially curative pancreatectomy. METHODS: In 110 patients with >10 examined lymph nodes (ELNs), we investigated how nodal statuses were associated with postoperative survival. Nodal statuses included the number of positive LNs (PLNs); the ratio of PLNs to ELNs (lymph node ratio; LNR); and the location of regional LN metastases, classified as group one (peripancreatic area) and group 2 (outside the peripancreatic area)...
January 16, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28117220/pancreatic-cysts-diagnostic-accuracy-and-risk-of-inappropriate-resections
#17
N de Pretis, S Mukewar, A Aryal-Khanal, Y Bi, N Takahashi, S Chari
BACKGROUND: Pancreatic cystic neoplasms (PCN) frequently undergo surgery, given malignant potential. Pancreatic cyst surgery is associated with significant rates of morbidity and mortality. It is crucial to accurately characterize these lesions pre-operatively to avoid unnecessary surgery in patients with benign pancreatic cysts. AIM: We aimed to assess the correlation between pre-operative (pre-op) diagnosis based on imaging and clinical presentation, and post-operative (post-op) diagnosis based on histopathology in patients undergone pancreatic cyst surgery...
January 12, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28089307/corrigendum-to-beneficial-effects-of-5-fluorouracil-and-heparin-based-portal-infusion-chemotherapy-combined-with-mitomycin-c-and-cisplatin-after-curative-resection-of-pancreatic-cancer-pancreatology-10-2010-250-258
#18
Koichi Aiura, Shin Takahashi, Junichi Matsui, Masakazu Ueda, Yuko Kitagawa
No abstract text is available yet for this article.
January 11, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28089101/reply-to-the-letter-regarding-early-dual-drainage-combining-transpapillary-endotherapy-and-percutaneous-catheter-drainage-in-patients-with-pancreatic-fistula-associated-with-severe-acute-pancreatitis
#19
EDITORIAL
Yoshihiro Yokoi, Masataka Kikuyama
No abstract text is available yet for this article.
January 3, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28063781/carbon-ion-radiotherapy-and-completion-pancreatectomy-a-feasible-model-to-explore-a-new-integrated-approach
#20
LETTER
Lorenzo Cobianchi, Piero Fossati, Andrea Peloso, Silvia Brugnatelli, Alessandro Vanoli, Francesca Valvo, Roberto Orecchia, Paolo Dionigi
No abstract text is available yet for this article.
December 30, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
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