journal
MENU ▼
Read by QxMD icon Read
search

Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]

journal
https://www.readbyqxmd.com/read/30201440/different-biological-behaviors-in-left-sided-pancreatic-cancer-according-to-yonsei-criteria-proposal-of-a-modified-yonsei-criteria-score
#1
Seoung Yoon Rho, Mijin Yun, Chang Moo Kang, Sung Hwan Lee, Ho Kyoung Hwang, Woo Jung Lee
BACKGROUND/OBJECTIVES: Our institutional experience has demonstrated that bloodless and margin-negative resection is the most potent prognostic factor in treating left-sided pancreatic cancer and we developed selection guideline. The Yonsei criteria (YC) is selection criteria for oncologically safe and effective resection of left-sided pancreatic cancer by a minimally invasive approach. In this study, we investigated whether left-sided pancreatic cancer with YC can be more individualized to predict long-term survival by using clinically and pathologically detectable parameters...
September 4, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30224296/comparison-between-groove-carcinoma-and-groove-pancreatitis
#2
Jae Hyuck Jun, Sung Koo Lee, So Yeon Kim, Dong Hui Cho, Tae Jun Song, Do Hyun Park, Sang Soo Lee, Dong-Wan Seo, Myung-Hwan Kim
BACKGROUND/OBJECTIVES: The pancreatoduodenal groove (anatomical groove) is a potential space bordered by the head of the pancreas, duodenum, and common bile duct. Discerning between groove carcinoma (GC) and groove pancreatitis (GP) is often difficult, but clinically important. We retrospectively analyzed and compared the findings of computed tomography (CT), laboratory tests, and endoscopic ultrasound-fine needle aspiration (EUS-FNA) for GC and GP. METHODS: GC (n = 36) and GP (n = 44) patients at Asan Medical Center from January 1, 2000, to May 31, 2017 were retrospectively reviewed...
August 30, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30177434/guidelines-for-the-diagnostic-cross-sectional-imaging-and-severity-scoring-of-chronic-pancreatitis
#3
Jens Brøndum Frøkjær, Fatih Akisik, Ammad Farooq, Burcu Akpinar, Anil Dasyam, Asbjørn Mohr Drewes, Ingfrid S Haldorsen, Giovanni Morana, John P Neoptolemos, Søren Schou Olesen, Maria Chiara Petrone, Andrea Sheel, Tooru Shimosoegawa, David C Whitcomb
The paper presents the international guidelines for imaging evaluation of chronic pancreatitis. The following consensus was obtained: Computed tomography (CT) is often the most appropriate initial imaging modality for evaluation of patients with suspected chronic pancreatitis (CP) depicting most changes in pancreatic morphology. CT is also indicated to exclude other potential intraabdominal pathologies presenting with symptoms similar to CP. However, CT cannot exclude a diagnosis of CP nor can it be used to exclusively diagnose early or mild disease...
August 28, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30201439/the-radiotherapy-sensitization-effect-of-cantharidin-mechanisms-involving-cell-cycle-regulation-enhanced-dna-damage-and-inhibited-dna-damage-repair
#4
Meng-Dan Xu, Shu-Ling Liu, Bei-Bei Zheng, Jing Wu, Meng-Yao Wu, Yan Zhang, Fei-Ran Gong, Min Tao, Junning Zhang, Wei Li
BACKGROUND: Cantharidin is an inhibitor of protein phosphatase 2 A (PP2A), and has been frequently used in clinical practice. In our previous study, we proved that cantharidin could arrest cell cycle in G2/M phase. Since cells at G2/M phase are sensitive to radiotherapy, in the present study, we investigated the radiotherapy-sesitization effect of cantharidin and the potential mechanisms involved. METHODS: Cell growth was determined by MTT assay. Cell cycle was evaluated by flow cytometry...
August 24, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30217697/overexpression-of-gp73-promotes-cell-invasion-migration-and-metastasis-by-inducing-epithelial-mesenchymal-transition-in-pancreatic-cancer
#5
Yin-Xue Song, Zhi-Chao Xu, Hui-Ling Li, Pei-Lei Yang, Jun-Kai Du, Jing Xu
Pancreatic cancer is one of the most difficult clinical cases to diagnose with a very low 5-year survival rate of 5%, regardless of the advances made in both the medical and surgical treatment of the disease. One of the contributing factors for the high mortality rate seen of pancreatic cancer patients is the lack of effective chemotherapies, which is believed to be due to drug-resistance. Based on recent evidence, epithelial-mesenchymal transition (ETM) of pancreatic cancer cells has been found to be associated with the development of drug resistance and an increase in cell invasion...
August 23, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30146334/an-audit-of-percutaneous-drainage-for-acute-necrotic-collections-and-walled-off-necrosis-in-patients-with-acute-pancreatitis
#6
Bipadabhanjan Mallick, Narendra Dhaka, Pankaj Gupta, Ajay Gulati, Sarthak Malik, Saroj K Sinha, Thakur D Yadav, Vikas Gupta, Rakesh Kochhar
BACKGROUND AND OBJECTIVES: Percutaneous catheter drainage (PCD) is used as a first step in the management of symptomatic fluid collections in patients with acute pancreatitis (AP). We aimed to compare the outcome of patients with acute necrotic collection (ANC) and those with walled-off necrosis (WON), who had undergone PCD as a part of management of AP. METHODS: Consecutive patients of AP with symptomatic ANC or WON undergoing PCD were evaluated. Primary outcome measures were need for additional surgical necrosectomy and mortality...
August 21, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30139657/pancreatic-cystosis-in-patients-with-cystic-fibrosis-a-qualitative-systematic-review
#7
REVIEW
Chirag S Desai, Jennifer S Vonderau, Rebecca McCall, Khalid M Khan, Todd H Baron
BACKGROUND: Patients with cystic fibrosis (CF) and a CFTR gene mutation may present with a variety of pancreatic disorders. The presence of multiple macrocysts (>1 cm) replacing the entire pancreatic parenchyma is termed pancreatic cystosis. Lack of clear data makes clinical decision making challenging and controversial. The aim of this review is to perform a qualitative systematic analysis of the literature with intention to evaluate management plans. METHODS: Electronic databases MEDLINE, Embase, and Scopus were searched for relevant studies, and 19 studies describing patients with pancreatic cystosis were included and analyzed for clinical features and therapy offered...
August 17, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30150111/rna-sequence-analysis-reveals-pathways-and-candidate-genes-associated-with-liver-injury-in-a-rat-pancreatitis-model
#8
Qian Wang, Xin Zhang, Shuanghong Lei, Yi Wang, Yongjing Zhuang, Yi Chen, Chao Zeng, Huan Zhang, Chaoxu Liu, Gang Wang
BACKGROUND: The morbidity and mortality associated with acute pancreatitis (AP) are largely attributable to abnormalities that occur in distant organs, such as liver and lungs. Pancreatitis-associated liver injury (PALI) remains a serious and even fatal complication during the progression of AP. However, the exact pathophysiological mechanism is still unclear. METHODS: In the present study, we used, for the first time, RNA-seq method to reveal pathways and candidate genes associated with PALI in rats...
August 16, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30139658/rcan1-is-a-marker-of-oxidative-stress-induced-in-acute-pancreatitis
#9
K Jessica Norberg, Salvatore Nania, Xuan Li, Hui Gao, Peter Szatmary, Ralf Segersvärd, Stephan Haas, Annika Wagman, Urban Arnelo, Robert Sutton, Rainer L Heuchel, J Matthias Löhr
BACKGROUND: To date, there still is a lack of specific acute pancreatitis markers and specifically an early marker that can reliably predict disease severity. The inflammatory response in acute pancreatitis is mediated in part through oxidative stress and calcineurin-NFAT (Nuclear Factor of Activated T-cells) signaling, which is inducing its own negative regulator, regulator of calcineurin 1 (RCAN1). Caerulein induction is a commonly used in vivo model of experimental acute pancreatitis...
August 16, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30115562/endoscopic-ultrasound-appearance-of-pancreatic-serotonin-staining-neuroendocrine-neoplasms
#10
Sara Massironi, Stefano Partelli, Maria C Petrone, Alessandra Zilli, Dario Conte, Massimo Falconi, Paolo G Arcidiacono
BACKGROUND/OBJECTIVES: The pancreatic localization of serotonin-staining neuroendocrine neoplasms is extremely rare. This is a retrospective study aimed at analyzing the endoscopic ultrasound appearance of pancreatic serotoninoma. METHODS: Between 2010 and 2016, all consecutive patients with histologically proven pancreatic serotoninoma who had undergone endoscopic ultrasound were enrolled. RESULTS: Eight patients (six F, median age 68.5 years) had a diagnosis of pancreatic serotoninoma and underwent endoscopic ultrasound examinations...
August 11, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30131287/new-observations-on-the-utility-of-ca19-9-as-a-biomarker-in-lewis-negative-patients-with-pancreatic-cancer
#11
Guopei Luo, Zhiyao Fan, He Cheng, Kaizhou Jin, Meng Guo, Yu Lu, Chao Yang, Kun Fan, Qiuyi Huang, Jiang Long, Liang Liu, Jin Xu, Renquan Lu, Quanxing Ni, Andrew L Warshaw, Chen Liu, Xianjun Yu
BACKGROUND: Carbohydrate antigen 19-9 (CA19-9) is the best-validated biomarker for pancreatic cancer. The National Comprehensive Cancer Network (NCCN) guideline asserts that "CA19-9 will be undetectable in Lewis antigen-negative individuals". However, reports of CA19-9 secretion and its significance in Lewis (-) patients with pancreatic cancer have been inconsistent. This study was to examine serum CA19-9 levels in patients with pancreatic cancer according to Lewis status. METHODS: Patients with pancreatic cancer (1482 cases) were retrieved from a prospectively maintained database...
August 9, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30119992/the-diagnostic-value-of-rosemont-and-japanese-diagnostic-criteria-for-indeterminate-suggestive-possible-and-early-chronic-pancreatitis
#12
Andrea R G Sheel, Ryan D Baron, Ioannis Sarantitis, Jayapal Ramesh, Paula Ghaneh, Michael G T Raraty, Vincent Yip, Robert Sutton, Michael R Goulden, Fiona Campbell, Ammad Farooq, Priya Healey, Richard Jackson, Christopher M Halloran, John P Neoptolemos
BACKGROUND: Longitudinal data are lacking to support consensus criteria for diagnosing early chronic pancreatitis. METHODS: Retrospective single centre study of the initial evidence for chronic pancreatitis (CP), with reassessment after follow-up (January 2003-November 2016). RESULTS: 807 patients were previously diagnosed with chronic pancreatitis. This diagnosis was rejected in 118 patients: 52 had another pathology altogether, the remaining 66 patients formed the study population...
August 7, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30115563/quercetin-protects-against-intestinal-barrier-disruption-and-inflammation-in-acute-necrotizing-pancreatitis-through-tlr4-myd88-p38-mapk-and-ers-inhibition
#13
Zheng Junyuan, Xu Hui, Huang Chunlan, Fan Junjie, Mei Qixiang, Lu Yingying, Lou Lihong, Wang Xingpeng, Zeng Yue
OBJECTIVE: To investigate the effects of quercetin on intestinal barrier disruption and inflammation in acute necrotizing pancreatitis (ANP) in rats, and its possible mechanism. METHODS: ANP was established by retrograde injection of 3.5% sodium taurocholate into the biliopancreatic duct, and quercetin (50 mg/kg × 3) was administered by intraperitoneal injection prior to and after ANP induction. Pancreatitis was assessed by pancreatic histopathology, plasma amylase, pancreatic myeloperoxidase (MPO) activity, IL-1β, TNFα and IL-6 levels...
August 6, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30078614/functions-of-the-cxc-ligand-family-in-the-pancreatic-tumor-microenvironment
#14
REVIEW
Nien-Hung Lee, Mehrdad Nikfarjam, Hong He
Therapeutic resistance is the major contributor to the poor prognosis of and low survival from pancreatic cancer (PC). Cancer progression is a complex process reliant on interactions between the tumor and the tumor microenvironment (TME). Members of the CXCL family of chemokines are present in the pancreatic TME and seem to play a vital role in regulating PC progression. As pancreatic tumors interact with the TME and with PC stem cells (CSCs), determining the roles of specific members of the CXCL family is vital to the development of improved therapies...
August 1, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30108023/patients-with-pancreatic-cystic-neoplasms-can-benefit-from-management-of-multidisciplinary-team-experience-from-a-chinese-academic-center
#15
Yiwen Chen, Chengxiang Guo, Qi Zhang, Yinan Shen, Yuwei Li, Xiang Li, Xueli Bai, Tingbo Liang
BACKGROUND: Pancreatic cystic neoplasms (PCNs) are a spectrum of neoplasms that can be benign or malignant. The accuracy of diagnosis is critical for this disease since different types of PCNs are treated differently using various modalities. The use of a multidisciplinary team (MDT) has been shown to improve the management and outcomes of various diseases. We aimed to determine the performance of MDT in the management of PCNs. METHODS: We retrospectively reviewed 167 pathologically-proven PCN patients and divided them among three groups according to their surgical data and treatment modalities: 1) historical control group (HC group); 2) concurrent control group (CC group); and 3) MDT group...
July 31, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30093353/endoscopic-ultrasound-elastography-in-the-diagnosis-of-pancreatic-masses-a-meta-analysis
#16
Binglan Zhang, Fuping Zhu, Pan Li, Shishi Yu, Yajing Zhao, Minmin Li
BACKGROUND AND AIMS: Endoscopic ultrasound (EUS) elastography is a novel non-invasive technique that can be used for distinguishing benign from malignant pancreatic masses. However, the studies have reported widely varied sensitivities and specificities. A meta-analysis was performed to assess the performance of EUS elastography for the differentiation of benign and malignant pancreatic masses. METHODS: All the eligible studies were searched by PubMed, Medline, Embase, and the Cochrane Library...
July 30, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30143405/progression-to-pancreatic-ductal-adenocarcinoma-from-pancreatic-intraepithelial-neoplasia-results-of-a-simulation-model
#17
Mary Linton B Peters, Andrew Eckel, Peter P Mueller, Angela C Tramontano, Davis T Weaver, Anna Lietz, Chin Hur, Chung Yin Kong, Pari V Pandharipande
OBJECTIVES: To gain insight into the natural history and carcinogenesis pathway of Pancreatic Intraepithelial Neoplasia (PanIN) lesions by building a calibrated simulation model of PanIN progression to pancreatic ductal adenocarcinoma (PDAC) METHODS: We revised a previously validated simulation model of solid PDAC, calibrating the model to fit data from the National Cancer Institute's Surveillance, Epidemiology, and End Results program and published literature on PanIN prevalence by age...
July 29, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30075908/protocol-digest-of-randomized-phase-ii-study-of-modified-folfirinox-versus-gemcitabine-plus-nab-paclitaxel-combination-therapy-for-locally-advanced-pancreatic-cancer-japan-clinical-oncology-group-study-jcog1407
#18
Junki Mizusawa, Akira Fukutomi, Hiroshi Katayama, Hiroshi Ishii, Tatsuya Ioka, Takuji Okusaka, Hideki Ueno, Makoto Ueno, Masafumi Ikeda, Nobumasa Mizuno, Masato Ozaka, Haruhiko Fukuda, Junji Furuse
Gemcitabine is one of the standard treatments for locally advanced pancreatic cancer. Recent studies on metastatic pancreatic cancer have shown that combination chemotherapy with oxaliplatin, irinotecan, fluorouracil, and leucovorin (FOLFIRINOX) and gemcitabine plus nab-paclitaxel (GnP) prolonged the overall survival compared with gemcitabine alone. To select the most promising chemotherapy, a randomized phase II selection design trial was started in July 2016 to compare between modified FOLFIRINOX and GnP for patients with locally advanced pancreatic cancer...
July 27, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30072207/the-prevalence-of-pancreatic-morphological-abnormalities-detected-by-digital-autopsy
#19
LETTER
Jennifer A Campbell, James N S Hampton, Matthias Löhr, Chris Howard, David S Sanders, Andrew D Hopper
No abstract text is available yet for this article.
July 6, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30153903/postoperative-serum-ca19-9-cea-and-ca125-predicts-the-response-to-adjuvant-chemoradiotherapy-following-radical-resection-in-pancreatic-adenocarcinoma
#20
Hua-Xiang Xu, Shuo Li, Chun-Tao Wu, Zi-Hao Qi, Wen-Quan Wang, Wei Jin, He-Li Gao, Shi-Rong Zhang, Jin-Zhi Xu, Chen Liu, Jiang Long, Jin Xu, Quan-Xing Ni, Xian-Jun Yu, Liang Liu
OBJECTIVE: To evaluate the prediction of benefits from adjuvant chemoradiotherapy by postoperative serum CA19-9, CA125 and CEA. METHODS: The relations between benefits from adjuvant chemoradiotherapy and levels of postoperative serum CA19-9, CA125 and CEA were investigated in 804 pancreatic adenocarcinoma patients who received radical resection. RESULTS: Adjuvant chemoradiotherapy was an independent factor for late recurrence [12.2 vs. 8.5 months, P = 0...
September 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
journal
journal
35534
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"