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Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]

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https://www.readbyqxmd.com/read/28506430/george-e-palade-memorial-lecture-my-life-in-pancreatic-research-unexpected-results-may-open-the-door
#1
REVIEW
Makoto Otsuki
The Palade Prize is the most distinguished award of the IAP for achievement in pancreatic research. It is named after George E. Palade, who in 1974 was awarded the Nobel Prize for his work on protein trafficking in pancreatic acinar cells. It is a great honor to be awarded the 2016 Palade Prize. While I was in graduate school, I was conducting research on hypothalamo-pituitary-thyroid axis; after finishing graduate school, I began research on amylase isoenzymes. This was the first step of my pancreatic research...
May 6, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28506431/usefulness-of-three-dimensional-magnetic-resonance-cholangiopancreatography-with-partial-maximum-intensity-projection-for-diagnosing-autoimmune-pancreatitis
#2
Shin Yanagisawa, Yasunari Fujinaga, Takayuki Watanabe, Masahiro Maruyama, Takashi Muraki, Masaaki Takahashi, Akira Fujita, Sachie Fujita, Masahiro Kurozumi, Kazuhiko Ueda, Hideaki Hamano, Shigeyuki Kawa, Masumi Kadoya
PURPOSE: To compare three-dimensional magnetic resonance cholangiopancreatography (MRCP) with/without partial maximum intensity projection (MIP) and endoscopic retrograde cholangiopancreatography (ERCP) in patients with autoimmune pancreatitis (AIP). MATERIALS AND METHODS: Three-dimensional MRCP and ERCP images were retrospectively analyzed in 24 patients with AIP. We evaluated the narrowing length of the main pancreatic duct (NR-MPD), multiple skipped MPD narrowing (SK-MPD), and side branches arising from the narrowed portion of the MPD (SB-MPD) using four MRCP datasets: 5 original images (MIP5), 10 original images (MIP10), all original images (full-MIP), and a combination of these three datasets (a-MIP)...
May 5, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28487129/identification-of-potential-diagnostic-biomarkers-of-acute-pancreatitis-by-serum-metabolomic-profiles
#3
Hong Xiao, Jian-Hua Huang, Xing-Wen Zhang, Rida Ahmed, Qing-Ling Xie, Bin Li, Yi-Ming Zhu, Xiong Cai, Qing-Hua Peng, Yu-Hui Qin, Hui-Yong Huang, Wei Wang
Acute pancreatitis (AP) is defined as an acute inflammation of pancreas that may cause damage to other tissues and organs depending upon the severity of symptoms. The diagnosis of AP is usually made by detection of raised circulating pancreatic enzyme levels, but there are occasional false positive and false negative diagnoses and such tests are often normal in delayed presentations. More accurate biomarkers would help in such situations. In this study, the global metabolites' changes of AP patients (APP) were profiled by using gas chromatography-mass spectrometry (GC-MS)...
May 3, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28473229/atypical-flat-lesions-derive-from-pancreatic-acinar-cells
#4
Guido von Figura, Leonie Fahrenkrog-Petersen, Ana Hidalgo-Sastre, Daniel Hartmann, Norbert Hüser, Roland M Schmid, Matthias Hebrok, Nilotpal Roy, Irene Esposito
OBJECTIVES: Pancreatic ductal adenocarcinoma (PDAC) is thought to derive from different precursor lesions including the recently identified atypical flat lesions (AFL). While all precursor lesions and PDAC share ductal characteristics, there is an ongoing debate about the cellular origin of the different PDAC precursor lesions. In particular, pancreatic acinar cells have previously been shown to display a remarkable plasticity being able to undergo ductal dedifferentiation in the context of oncogenic stimuli...
April 25, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28476581/tumour-associated-macrophages-activate-migration-and-stat3-in-pancreatic-ductal-adenocarcinoma-cells-in-co-cultures
#5
Aino Salmiheimo, Harri Mustonen, Sanna Vainionpää, Zhanlong Shen, Esko Kemppainen, Pauli Puolakkainen, Hanna Seppänen
OBJECTIVES: Tumour-associated macrophages participate in tumour development and progression. The aim of this study was to assess the interactions of pancreatic cancer cells and pro-inflammatory M1 and anti-inflammatory M2 macrophages, specifically their effect on pancreatic cancer cell migration and the changes in STAT-signalling. METHODS: Monocytes were isolated from healthy subjects and differentiated into macrophages with M-CSF. The macrophages were polarized towards M1 by IL-12 and towards M2 by IL-10...
April 24, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28476582/enhanced-karyopherin-%C3%AE-2-expression-is-associated-with-carcinogenesis-in-patients-with-intraductal-papillary-mucinous-neoplasms
#6
Norio Kubo, Kenichiro Araki, Bolag Altan, Kouki Hoshino, Norihiro Ishii, Mariko Tsukagoshi, Takamichi Igarashi, Akira Watanabe, Toshihide Kato, Keitaro Hirai, Takehiko Yokobori, Fumiyoshi Saito, Hideki Suzuki, Hiroyuki Kuwano, Ken Shirabe
BACKGROUND/OBJECTIVES: Intraductal papillary mucinous neoplasms (IPMN) can become malignant. Karyopherin-α2 (KPNA2) plays a central role in nucleocytoplasmic transport and is associated with various types of cancer. The current study examined pancreatic KPNA2 expression in cancer patients and evaluated its association with clinicopathological factors, cancer cell proliferation. METHODS: KPNA2 expression was investigated by immunohistochemistry in 40 surgically resected IPMN samples and its association with clinicopathological factors and Ki-67 expression were examined...
April 23, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28462862/high-prevalence-of-incidental-and-symptomatic-venous-thromboembolic-events-in-patients-with-advanced-pancreatic-cancer-under-palliative-chemotherapy-a-retrospective-cohort-study
#7
Anne Katrin Berger, Hans Martin Singh, Wiebke Werft, Alexander Muckenhuber, Martin R Sprick, Andreas Trumpp, Wilko Weichert, Dirk Jäger, Christoph Springfeld
OBJECTIVES: Pancreatic cancer patients are at high risk for venous thromboembolic events (VTEs), and chemotherapy is a known additional risk factor. In this context, there is a controversial discussion whether prophylactic anticoagulation should be offered to all outpatients receiving chemotherapy. METHODS: In this retrospective study, we analyzed incidental and symptomatic VTEs in 150 pancreatic cancer patients receiving either gemcitabine-based chemotherapy or chemotherapy according to the FOLFIRINOX protocol...
April 22, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28462863/diagnosis-of-exocrine-pancreatic-insufficiency-in-chronic-pancreatitis-13c-mixed-triglyceride-breath-test-versus-fecal-elastase-methodological-issues
#8
LETTER
Saeid Safiri, Erfan Ayubi
No abstract text is available yet for this article.
April 17, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28501471/comparison-of-endoscopic-ultrasound-guided-fine-needle-aspiration-and-pet-ct-in-preoperative-diagnosis-of-pancreatic-adenocarcinoma
#9
Jin-Ping Lai, Yong Yue, Wei Zhang, Yihua Zhou, David Frishberg, Laith H Jamil, James M Mirocha, Maha Guindi, Bonnie Balzer, Shikha Bose, Dengfeng Cao, Simon Lo, Xuemo Fan, Joanne K Rutgers
BACKGROUND: Endoscopic ultrasound guided fine needle aspiration (EUS-FNA) is the procedure of choice to investigate and sample pancreatic masses for the preoperative diagnosis of pancreatic ductal adenocarcinoma (PDAC). The role of (18)fluoro-deoxyglucose positron emission tomography/computed tomography (PET/CT) in PDAC is debated. This study evaluates the role of EUS-FNA as compared to PET/CT in the preoperative evaluation of PDAC. METHODS: Preoperative evaluation by PET/CT and EUS-FNA was performed on 25 patients with pancreatic solid lesions, who underwent a subsequent Whipple procedure or partial pancreatic resection...
April 13, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28434838/comment-re-optimize-ca19-9-in-detecting-pancreatic-cancer-by-lewis-and-secretor-genotyping
#10
EDITORIAL
A Wannhoff, K H Weiss, T Hackert, D N Gotthardt
No abstract text is available yet for this article.
April 12, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28416384/overexpressed-hspa2-correlates-with-tumor-angiogenesis-and-unfavorable-prognosis-in-pancreatic-carcinoma
#11
Lu-Lu Zhai, Qi Xie, Chun-Hua Zhou, Da-Wei Huang, Zhi-Gang Tang, Tong-Fa Ju
Heat shock-related 70-kDa protein 2 (HSPA2) is known to correlate with tumor development and progression. This work aimed to determine the expression and prognostic roles of HSPA2 in pancreatic carcinoma. Tumor and their corresponding non-tumor tissues were obtained from 80 patients with pancreatic carcinoma. HSPA2 expression in tumor and non-tumor tissues was evaluated by immunohistochemistry. Expression of vascular endothelial growth factor (VEGF) and CD31 in tumor tissues were also evaluated by immunostaining...
April 12, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28416122/patients-with-a-resected-pancreatic-mucinous-cystic-neoplasm-have-a-better-prognosis-than-patients-with-an-intraductal-papillary-mucinous-neoplasm-a-large-single-institution-series
#12
James F Griffin, Andrew J Page, Georges J Samaha, Adrienne Christopher, Feriyl Bhaijee, Maryam K Pezhouh, Niek A Peters, Ralph H Hruban, Jin He, Martin A Makary, Anne Marie Lennon, John L Cameron, Christopher L Wolfgang, Matthew J Weiss
BACKGROUND/OBJECTIVES: Mucinous cystic neoplasms (MCNs) are rare pancreas tumors distinguished from intraductal papillary mucinous neoplasms (IPMNs) by the presence of ovarian-type stroma. Historical outcomes for MCNs vary due to previously ambiguous diagnostic criteria resulting in confusion with IPMNs. This study seeks to characterize and clarify the clinical features and long-term outcomes of MCNs versus IPMNs in the largest single-institution series of pathology-confirmed MCNs to date...
April 11, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28456590/management-of-patients-with-pancreatic-cystic-lesions-a-case-based-survey
#13
B Müssle, M Distler, S Wolk, S V Shrikhande, D E Aust, A Arlt, J Weitz, T Hackert, T Welsch
BACKGROUND: Pancreatic cystic lesions (PCL), including intraductal papillary mucinous neoplasia (IPMN), harbor different malignant potential and the optimal management is often challenging. The present study aims to depict the compliance of experts with current consensus guidelines and the accuracy of treatment recommendations stratified by the medical specialty and hospital volume. METHODS: An international survey was conducted using a set of 10 selected cases of PCL that were presented to a cohort of international experts on pancreatology...
April 10, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28411019/comparison-of-surgical-outcomes-of-three-different-stump-closure-techniques-during-distal-pancreatectomy
#14
Ilhan Karabicak, Sohei Satoi, Hiroaki Yanagimoto, Tomohisa Yamamoto, So Yamaki, Hisashi Kosaka, Satoshi Hirooka, Masaya Kotsuka, Taku Michiura, Kentaro Inoue, Yoichi Matsui, Masanori Kon
BACKGROUND: To find the appropriate method of pancreatic transection during distal pancreatectomy (DP), we retrospectively compared post-operative complications including postoperative pancreatic fistula (POPF) according to the different types of pancreatic transection. METHODS: This study included 169 patients who underwent pancreatic transection using an ultrasonic activated device (USAD) with transfixion of the pancreatic duct (DP-TF group, n = 89), USAD followed by pancreaticogastrostomy (DP-PG group, n = 44), and a reinforced linear tristapler (DP-ST, n = 36)...
April 8, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28412148/no-evidence-to-support-a-role-for-helicobacter-pylori-infection-and-plasminogen-binding-protein-in-autoimmune-pancreatitis-and-igg4-related-disease-in-a-uk-cohort
#15
Emma L Culver, Wouter L Smit, Caroline Evans, Ross Sadler, Tamsin Cargill, Mateusz Makuch, Lai-Mun Wang, Berne Ferry, Paul Klenerman, Eleanor Barnes
BACKGROUND AND OBJECTIVES: Helicobacter pylori (H.pylori) plasminogen binding protein (PBP) has been proposed as an antigen triggering autoimmune pancreatitis (AIP), the pancreatic manifestation of IgG4-related disease (IgG4-RD). We investigated exposure to H. pylori infection, cytokine response and immunological memory to H. pylori PBP in a prospective IgG4-RD cohort in the UK. METHODS: Clinical and endoscopic evidence of peptic ulceration, serological H. pylori exposure and serum IgG4 levels were obtained in 55 IgG4-RD patients and 52 disease controls (DC) with autoimmune or inflammatory conditions with an elevated serum IgG4...
April 5, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28499807/evaluation-of-insulin-like-growth-factor-igf-1-and-retinol-binding-protein-rbp-4-levels-in-patients-with-newly-diagnosed-pancreatic-adenocarcinoma-pdac
#16
Barbara Wlodarczyk, Anita Gasiorowska, Anna Borkowska, Ewa Malecka-Panas
BACKGROUND/OBJECTIVES: The elevation of insulin-like growth factor 1 (IGF-1) and adipokine retinol-binding protein 4 (RBP-4) is known to be associated with the risk of many cancers. The aim of this study was to evaluate the serum concentrations of IGF-1 and RBP-4 in patients with PDAC and chronic pancreatitis (CP). METHODS: The study included 43 patients with PDAC, 39 patients with CP and 10 controls. The concentrations of IGF-1 and RBP-4 were obtained using the ELISA method (Corgenix UK Ltd R&D Systems)...
April 4, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28366422/efficacy-and-safety-of-postoperative-anticoagulation-prophylaxis-with-enoxaparin-in-patients-undergoing-pancreatic-surgery-a-prospective-trial-and-literature-review
#17
Daisuke Hashimoto, Shigeki Nakagawa, Naoki Umezaki, Takanobu Yamao, Yuki Kitano, Kensuke Yamamura, Takayoshi Kaida, Kota Arima, Katsunori Imai, Yo-Ichi Yamashita, Akira Chikamoto, Hideo Baba
BACKGROUND: /Objectives: Enoxaparin is low-molecular-weight heparin that is used for postoperative thromboprophylaxis. The purpose of this study was to evaluate the efficacy and safety of enoxaparin after pancreatic resection. We additionally carried out a literature review regarding venous thromboembolism (VTE) and postoperative bleeding mainly after hepatobiliary-pancreatic surgery. METHODS: This was a prospective, single-arm study. Patients aged 20-79 years who planned to undergo pancreatic resection followed by postoperative anticoagulation therapy with enoxaparin were enrolled from 2013 to 2016...
March 29, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28372957/hypercoagulability-after-distal-pancreatectomy-just-meaningless-alterations
#18
Matthias Hassenpflug, Christin Tjaden, Ulf Hinz, Johanna Volpert, Thilo Hackert, Markus W Büchler, Jens Werner
BACKGROUND: Perioperative and short-term postoperative parameters are similar comparing spleen-preserving distal pancreatectomy (SPDP) and distal pancreatectomy with splenectomy (DPS). But there are no sound data evaluating the long term risk of postoperative thromboses and infectious complications after splenectomy. The present study evaluated whether the coagulation status differs in patients after SPDP and DPS, and whether that matters clinically. METHODS: A total of 41 patients after DP (SPDP = 20; DPS = 21) were followed up, focusing on alterations of patient coagulation and immune status...
March 19, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28365128/diagnosing-autoimmune-pancreatitis-with-the-unifying-autoimmune-pancreatitis-criteria
#19
Alexander Schneider, Henrik Michaely, Felix Rückert, Christel Weiss, Philipp Ströbel, Sebastian Belle, Michael Hirth, Torsten J Wilhelm, Stephan L Haas, Ralf Jesenofsky, Stefan Schönberg, Alexander Marx, Manfred V Singer, Matthias P Ebert, Roland H Pfützer, J Matthias Löhr
BACKGROUND/OBJECTIVES: We had developed the Unifying-Autoimmune-Pancreatitis-Criteria (U-AIP) to diagnose autoimmune pancreatitis (AiP) within the M-ANNHEIM classification of chronic pancreatitis. In 2011, International-Consensus-Diagnostic-Criteria (ICDC) to diagnose AiP have been published. We had applied the U-AIP long before the ICDC were available. The aims of the study were, first, to describe patients with AiP diagnosed by the U-AIP; second, to compare diagnostic accuracies of the U-AIP and other diagnostic systems; third, to evaluate the clinical applicability of the U-AIP...
March 18, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28342645/the-expression-and-activation-of-the-aim2-inflammasome-correlates-with-inflammation-and-disease-severity-in-patients-with-acute-pancreatitis
#20
Francisco Algaba-Chueca, Enrique de-Madaria, Beatriz Lozano-Ruiz, Claudia Martínez-Cardona, Noé Quesada-Vázquez, Victoria Bachiller, Fabián Tarín, José Such, Rubén Francés, Pedro Zapater, José M González-Navajas
BACKGROUND: Acute pancreatitis is an inflammatory disorder of the pancreas that is responsible for significant morbidity and mortality. The inflammasome pathway has acquired significant relevance in the pathogenesis of many inflammatory disorders, but its role in patients with acute pancreatitis still awaits clarification. METHODS: We performed a prospective study in which 27 patients with acute pancreatitis and 16 healthy controls were included. We isolated peripheral blood mononuclear cells (PBMCs) and we assessed the expression and activation of different inflammasomes as well as their association with the clinical course of the disease...
March 18, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
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