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Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]

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https://www.readbyqxmd.com/read/30448085/a-steady-decline-in-pancreas-transplantation-rates
#1
Stan Benjamens, Marjolein Leemkuil, Christian Margreiter, Volkert Al Huurman, Henri Gd Leuvenink, Robert A Pol
BACKGROUND/OBJECTIVES: After years of growth in many pancreas transplant programs, UNOS has reported declining transplant numbers in the USA. This precipitating trend urges for an evaluation of the transplant numbers and scientific productivity in the Eurotransplant region and the UK. METHODS: We performed a trend analysis of pancreas transplantation rates, between 1997 and 2016, adjusting for changes in population size, and an analysis of scientific publications in this field...
November 10, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30416041/claudin-7-as-a-possible-novel-molecular-target-for-the-treatment-of-pancreatic-cancer
#2
Norimitsu Okui, Yuko Kamata, Yukiko Sagawa, Akiko Kuhara, Kazumi Hayashi, Tadashi Uwagawa, Sadamu Homma, Katsuhiko Yanaga
BACKGROUND/OBJECTIVES: Pancreatic cancer consists of various subpopulations of cells, some of which have aggressive proliferative properties. The molecules responsible for the aggressive proliferation of pancreatic cancer may become molecular targets for the therapies against pancreatic cancer. METHODS: From a human pancreatic cancer cell line, MIA PaCa-2, MIA PaCa-2-A cells with an epithelial morphology and MIA PaCa-2-R cells with a non-epithelial morphology were clonogenically isolated by the limiting dilution method...
November 2, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30393009/microrna-let-7d-targets-thrombospondin-1-and-inhibits-the-activation-of-human-pancreatic-stellate-cells
#3
Hiroyuki Asama, Rei Suzuki, Takuto Hikichi, Tadayuki Takagi, Atsushi Masamune, Hiromasa Ohira
OBJECTIVES: The microRNA (miRNA) let-7d is linked to the formation of pancreatic cancer-related fibrosis. In this study, the mechanism by which let-7d regulates the activation of the human pancreatic stellate cell (hPSC) was evaluated. METHODS: The transient transfection of a let-7d mimic in the hPSCs was performed, and the altered thrombospondin 1 (THBS1) expression was confirmed by western blotting and real-time qPCR. Targeting of the 3'-untranslated region (UTR) of THBS1 by let-7d was investigated by the luciferase assays...
October 30, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30391116/pancreatic-vipomas-from-china-case-reports-and-literature-review
#4
Chuyan Chen, Zhibo Zheng, Binglu Li, Liangrui Zhou, Junyi Pang, Wenming Wu, Chaoji Zheng, Yupei Zhao
Vasoactive intestinal polypeptide-secreting tumors (VIPomas) are rare neuroendocrine tumors that often present as watery diarrhea, hypokalemia, and achlorhydria or hypochlorhydria. In this study, we present our institutional experience of diagnosis and treatment of VIPomas, along with a review of the Chinese literature since 1980. Patient #1, diagnosed in 1984 and with intact clinical records, shows the natural history of this disease. Patient #2, diagnosed in 2015, shows the results of evaluation by nuclear medicine techniques and the outcomes of standardized treatment...
October 26, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30385188/enzyme-replacement-improves-survival-among-patients-with-pancreatic-cancer-results-of-a-population-based-study
#5
K J Roberts, C A Bannister, H Schrem
Pancreatic exocrine insufficiency (PEI) and malnutrition are prevalent among patients with pancreatic adenocarcinoma. Pancreatic enzyme replacement therapy (PERT) can correct PEI but its use among patients with pancreatic cancer is unclear as are effects upon survival. This population-based study sought to address these issues METHODS: Subjects with pancreatic adenocarcinoma were identified from the UK Clinical Practice Research Datalink (CPRD). Propensity score matching generated matched pairs of subjects who did and did not receive PERT...
October 24, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30366677/epidermoid-cyst-in-intrapancreatic-accessory-spleen-a-systematic-review
#6
REVIEW
Bing-Qi Li, Jun Lu, Samuel Seery, Jun-Chao Guo
BACKGROUND/OBJECTIVES: Due to its rarity, epidermoid cyst in intrapancreatic accessory spleen (ECIPAS) is still a diagnostic dilemma during clinical practice. The aim of this review was to summarize the epidemiologic features and management of ECIPAS. METHODS: MEDLINE and EMBASE were searched for English articles reporting on ECIPAS up to April 30th, 2018 following the methodology suggested by the PRISMA guidelines. Categorical variables were reported as frequency and percentage...
October 22, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30361069/cytokine-profile-in-prediction-of-acute-lung-injury-in-patients-with-acute-pancreatitis
#7
Jayanta Samanta, Sukhwinder Singh, Sunil Arora, Gaurav Muktesh, Ashutosh Aggarwal, Narendra Dhaka, Saroj Kant Sinha, Vikas Gupta, Vishal Sharma, Rakesh Kochhar
OBJECTIVES: To study the role of cytokines in prediction of acute lung injury (ALI) in acute pancreatitis. METHODS: Levels of TNFα, IL-6, IL-10, IL-8 and IL-1β were measured in 107 patients at presentation and at 72 h in patients who developed acute lung injury. A model was devised to predict development of ALI using cytokine levels and SIRS score. RESULTS: The levels of TNF α (p < 0.0001), IL-6 (p < 0.0001), IL-8 (p < 0...
October 18, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30396819/tumor-treating-fields-in-combination-with-gemcitabine-or-gemcitabine-plus-nab-paclitaxel-in-pancreatic-cancer-results-of-the-panova-phase-2-study
#8
Fernando Rivera, Manuel Benavides, Javier Gallego, Carmen Guillen-Ponce, José Lopez-Martin, Marc Küng
BACKGROUND: Tumor Treating Fields (TTFields), low intensity alternating electric fields with antimitotic activity, have demonstrated survival benefit in patients with glioblastoma. This phase 2 PANOVA study was conducted to examine the combination of TTFields plus chemotherapy in patients with pancreatic ductal adenocarcinoma (PDAC). METHODS: Forty patients with newly-diagnosed, locally advanced or metastatic PDAC received continuous TTFields (150 KHz for ≥18 h/day) plus gemcitabine (1000 mg/m2 ), or gemcitabine plus nab-paclitaxel (125 mg/m2 )...
October 17, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30366676/impact-of-timing-of-presentation-of-acute-pancreatitis-to-a-tertiary-care-centre-on-the-outcome
#9
Bipadabhanjan Mallick, Narendra Dhaka, Vishal Sharma, Sarthak Malik, Saroj K Sinha, Usha Dutta, Pankaj Gupta, Ajay Gulati, Thakur D Yadav, Vikas Gupta, Rakesh Kochhar
BACKGROUND AND OBJECTIVES: Despite improvement in outcomes of acute pancreatitis (AP), some subgroups remain at increased risk. We studied the impact of onset-to-admission interval to a tertiary care centre on outcomes in AP. METHODS: Retrospective analysis of consecutive patients with first episode of AP admitted between 2009 and 2017 on the basis of onset-to-admission interval: ≤7 days, 8-21 days and >21 days was done. Patients were assessed for severity and managed using a step-up approach...
October 17, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30396818/characterization-of-long-term-prognosis-in-acute-pancreatitis-an-explorative-analysis
#10
Mohannad Abou Saleh, Vijit Chouhan, Emad Mansoor, Dharani Guttikonda, Ashwinee Natu, Michael Enzerra, Raj Paspulati, David Ngendahimana, Bayan Alsuleiman, Lorna Kang, Brooke Glessing, Amitabh Chak, Tyler Stevens, Peter J Lee
BACKGROUND/OBJECTIVES: Severity classification systems of acute pancreatitis (AP) assess inpatient morbidity and mortality without predicting outpatient course of AP. To provide appropriate outpatient care, determinants of long-term prognosis must also be identified. The aim of this study was to define clinical groups that carry long-term prognostic significance in AP. METHODS: A retrospective study that included patients admitted with AP was conducted. Determinants of long-term prognosis were extracted: These included Revised Atlanta and Determinant Based Classification (RAC), Charlson Comorbidity Index (CCI), Modified CT Severity Index (MCTSI), etiology, and local complications (LCs)...
October 9, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30344091/recommendations-from-the-united-european-gastroenterology-evidence-based-guidelines-for-the-diagnosis-and-therapy-of-chronic-pancreatitis
#11
REVIEW
J Enrique Dominguez-Munoz, Asbjørn M Drewes, Björn Lindkvist, Nils Ewald, László Czakó, Jonas Rosendahl, J Matthias Löhr
BACKGROUND: In collaboration with United European Gastroenterology, the working group on 'Harmonizing diagnosis and treatment of chronic pancreatitis across Europe' (HaPanEU) developed European guidelines for the management of chronic pancreatitis using an evidence-based approach. METHODS: Recommendations of multidisciplinary review groups based on systematic literature reviews to answer predefined clinical questions are summarised. Recommendations are graded using the Grading of Recommendations Assessment, Development and Evaluation system...
October 6, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30337224/acute-pancreatitis-trends-in-outcomes-and-the-role-of-acute-kidney-injury-in-mortality-a-propensity-matched-analysis
#12
Kalpit Devani, Paris Charilaou, Dhruvil Radadiya, Bhaumik Brahmbhatt, Mark Young, Chakradhar Reddy
OBJECTIVES: To assess national trends of AP (acute pancreatitis) admissions, outcomes, prevalence of AKI (acute kidney injury) in AP, and impact of AKI on inpatient mortality. METHODS: We queried the Nationwide Inpatient Sample database from 2003 to 2012 to identify AP admissions using ICD-9-CM codes. After excluding patients with missing information on age, gender, and inpatient mortality, we used ICD-9-CM codes to identify complications of AP, specifically AKI...
October 5, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30293871/early-removal-of-metal-stents-in-walled-off-pancreatic-necrosis
#13
LETTER
Surinder Singh Rana, Ravi Sharma, Rajesh Gupta
No abstract text is available yet for this article.
October 2, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30297095/higher-notch-expression-implies-poor-survival-in-pancreatic-ductal-adenocarcinoma-a-systematic-review-and-meta-analysis
#14
Jianbin Ye, Junjie Wen, Yunshan Ning, Yan Li
BACKGROUND: At present, pancreatic ductal adenocarcinoma (PDAC) is a fetal disease lack of effective prognostic and therapeutic methods resulting in high mortality. The Notch signaling has been demonstrated being up- or down-regulated in many cancers, but the effects in pancreatic ductal adenocarcinoma are still controversial. Moreover, the available cases in an individual study are of small samples. Therefore, it is essential to define the effect of Notch signaling in pancreatic ductal adenocarcinoma with larger samples...
October 1, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30287168/systemic-chemotherapy-in-combination-with-liver-directed-therapy-improves-survival-in-patients-with-pancreatic-adenocarcinoma-and-synchronous-liver-metastases
#15
Huaqiang Ouyang, Weidong Ma, Ti Zhang, Fang Liu, Lujun Zhao, Minghui Fang, Manman Quan, Zhanyu Pan
OBJECTIVES: We investigated whether the combination of systemic chemotherapy (SCT) and liver-directed therapy (LDT) was superior to chemotherapy alone for patients with pancreatic adenocarcinoma and synchronous liver metastases (PACLM). METHODS: We reviewed the medical records of 184 patients treated with SCT ± LDT at Tianjin Medical University Cancer Hospital from 2001 to 2015. Overall survival (OS) was the primary end-point. The role of treatment modality and other clinical factors was evaluated by univariate and Cox regression analyses...
September 29, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30292643/diagnosis-and-management-of-pancreatic-cancer-in-adults-a-summary-of-guidelines-from-the-uk-national-institute-for-health-and-care-excellence
#16
REVIEW
Derek O'Reilly, Linyun Fou, Elise Hasler, James Hawkins, Susan O'Connell, Ferruccio Pelone, Mark Callaway, Fiona Campbell, Margred Capel, Richard Charnley, Pippa Corrie, Dawn Elliot, Lesley Goodburn, Anna Jewell, Suzanne Joharchi, Laura McGeeney, Somnath Mukherjee, Kofi Oppong, Phil Whelan, John Primrose, John Neoptolemos
To enable standardisation of care of pancreatic cancer patients and facilitate improvement in outcome, the United Kingdom's National Institute for Health and Care Excellence (NICE) developed a clinical guideline for the diagnosis and management of pancreatic cancer in adults. Systematic literature searches, systematic review and meta-analyses were undertaken. Recommendations were drafted on the basis of the group's interpretation of the best available evidence of clinical and cost effectiveness. There was patient involvement and public consultation...
September 28, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30279074/relationship-between-somatostatin-and-interleukin-6-a-cross-sectional-study-in-patients-with-acute-pancreatitis
#17
Mariola Sliwinska-Mosson, Grzegorz Marek, Zygmunt Grzebieniak, Halina Milnerowicz
OBJECTIVES: The aim of the analysis is to determine dynamic changes in somatostatin (SS) and interleukin-6 (IL-6) concentrations during in acute pancreatitis (AP). METHODS: The influence of tobacco smoking on IL-6 and SS levels in the serum of non-smoking (n = 10) and smoking (n = 27) patients with diagnosed AP and control group: non-smoking (n = 44), smoking (n = 42) and passive smoking (n = 29) healthy persons was proved. The concentration of IL-6 and SS was determined by means of ELISA...
September 28, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30287167/impact-of-preoperative-sarcopenia-on-postoperative-outcomes-following-pancreatic-resection-a-systematic-review-and-meta-analysis
#18
REVIEW
Chathura Bb Ratnayake, Benjamin Pt Loveday, Shailesh V Shrikhande, John A Windsor, Sanjay Pandanaboyana
BACKGROUND: Morphometric analysis of sarcopenia has garnered interest due to its putative role in predicting outcomes following surgery for a variety of pathologies, including resection for pancreatic disease. However, there are no standard recommendations on whether sarcopenia is a clinically relevant predictor of outcomes in this setting. The aim of this study was to review the prognostic impact of preoperatively diagnosed sarcopenia on postoperative outcomes following pancreatic resection...
September 27, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30292644/organotypic-slice-cultures-of-pancreatic-ductal-adenocarcinoma-preserve-the-tumor-microenvironment-and-provide-a-platform-for-drug-response
#19
Chae Yoon Lim, Jae Hyuck Chang, Won Sun Lee, Kang Min Lee, Young Chul Yoon, Jeana Kim, Il Young Park
BACKGROUND: /Objective: The conventional models currently used to evaluate various anti-tumor therapeutic agents are not sufficient for representing human pancreatic ductal adenocarcinoma (PDA), which has a unique tumor microenvironment. We aimed to produce an organotypic slice culture model from human PDA that resembles the in vivo situation and to evaluate the responses of PDA slices to established cytotoxic drugs. METHODS: PDA tissues were obtained from 10 patients who underwent pancreatic resection...
September 26, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30274883/management-of-pregnancy-associated-pancreatic-cystic-tumors-review-of-the-literature-and-results-of-a-pancreas-club-inc-survey
#20
REVIEW
Sara Iacopi, Carlo Lombardo, Francesca Menonna, Salvatore Mazzeo, Davide Caramella, Gabriella Amorese, Fabio Vistoli, Ugo Boggi
BACKGROUND/OBJECTIVES: Management of patients with pregnancy-associated cyst pancreatic cystic tumors (PA-PCT) is complicated by lack of large series. METHODS: A systematic literature review was conducted to extrapolate data on management of PA-PCT, and make a questionnaire on pending issues to be administered to the members of the Pancreas Club Inc. RESULTS: The literature review demonstrated a total of 35 PA-PCT in 34 women, described exclusively in the form of case reports, and permitted the identification of eleven key questions to be addressed in the survey...
September 26, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
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