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Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]

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https://www.readbyqxmd.com/read/28063781/carbon-ion-radiotherapy-and-completion-pancreatectomy-a-feasible-model-to-explore-a-new-integrated-approach
#1
LETTER
Lorenzo Cobianchi, Piero Fossati, Andrea Peloso, Silvia Brugnatelli, Alessandro Vanoli, Francesca Valvo, Roberto Orecchia, Paolo Dionigi
No abstract text is available yet for this article.
December 30, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28043759/baseline-plasma-chromogranin-a-levels-in-patients-with-well-differentiated-neuroendocrine-tumors-of-the-pancreas-a-potential-predictor-of-postoperative-recurrence
#2
Yoshihide Nanno, Hirochika Toyama, Ippei Matsumoto, Kyoko Otani, Sadaki Asari, Tadahiro Goto, Tetsuo Ajiki, Yoh Zen, Takumi Fukumoto, Yonson Ku
BACKGROUND: The present study aimed to elucidate prognostic values of baseline plasma chromogranin A (CgA) concentrations in patients with resectable, well-differentiated pancreatic neuroendocrine tumors (PNETs). METHODS: Preoperative CgA levels in 21 patients with PNET were correlated with clinicopathological factors and patients' survival. RESULTS: Plasma CgA levels ranged 2.9-30.8 pmol/mL (median 6.0), and were significantly elevated in patients with post-operative recurrence (P = 0...
December 29, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28065383/molecular-alterations-contributing-to-pancreatic-cancer-chemoresistance
#3
REVIEW
Azam Rajabpour, Farzad Rajaei, Ladan Teimoori-Toolabi
Pancreatic ductal adenocarcinoma (PDAC) is one of the most common causes of cancer-related death all over the world. This disease is difficult to treat and patients have an overall 5-year survival rate of less than 5%. Although two drugs, gemcitabine (GEM) and 5-fluorouracil (5-FU) have been shown to improve the survival rate of patients systematically, they do not increase general survival to a clinically acceptable degree. Lack of ideal clinical response of pancreatic cancer patients to chemotherapy is likely to be due to intrinsic and acquired chemoresistance of tumor cells...
December 28, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28040425/safety-and-efficacy-of-folfirinox-in-elderly-patients-with-metastatic-or-locally-advanced-pancreatic-adenocarcinoma-a-retrospective-analysis
#4
C Baldini, A Escande, O Bouché, F El Hajbi, J Volet, V Bourgeois, T Renaut Vantroys, A Ploquin, C Desauw, M Hebbar
BACKGROUND: FOLFIRINOX is a polychemotherapy regimen currently used to treat inoperable pancreatic cancer in patients with a good performance status (PS). FOLFIRINOX lengthens overall survival time (OS), but no specific data are available in elderly patients. METHODS: All cases of inoperable pancreatic adenocarcinoma in patients over 70 years old treated with FOLFIRINOX were retrospectively reviewed between 2008 and 2015 in five institutions in France. The primary objective was to evaluate the safety and efficacy of FOLFIRINOX in the elderly...
December 24, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28034552/is-autoimmune-pancreatitis-a-subclass-of-chronic-pancreatitis
#5
EDITORIAL
Zoltán Berger, Carla Mancilla
No abstract text is available yet for this article.
December 24, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28034553/microenvironment-in-determining-chemo-resistance-in-pancreatic-cancer-neighborhood-matters
#6
REVIEW
Patricia Dauer, Alice Nomura, Ashok Saluja, Sulagna Banerjee
Every year, nearly 300,000 people are diagnosed with pancreatic cancer worldwide, and an equivalent number succumb to this disease. One of the major challenges of pancreatic cancer that contributes to its poor survival rates is the development of resistance to the standard chemotherapy. Heterogeneity of the tumor, the dense fibroblastic stroma, and the aggressive biology of the tumor all contribute to the chemoresistant phenotype. In addition, the acellular components of the tumor microenvironment like hypoxia, stress pathways in the stromal cells, and the cytokines that are secreted by the immune cells, have a definitive role in orchestrating the chemoresistant property of the tumor...
December 23, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28027897/relevance-of-dihydropyrimidine-dehydrogenase-and-thymidylate-synthase-in-patients-with-pancreatic-neuroendocrine-neoplasms-treated-with-5-fu-based-chemotherapy
#7
S Krug, M Boch, W Nimphius, T M Gress, P Michl, A Rinke
BACKGROUND: Chemotherapy with 5-FU and Streptozotocin (STZ) is recommended as first-line treatment in patients with metastatic pancreatic neuroendocrine neoplasms (PNEN). However, data about biomarkers involved in the 5-FU metabolism to predict response are still limited. OBJECTIVES: Evaluation of clinicopathological features and potential predictive and prognostic markers of patients with PNEN treated with 5-FU based regimens. PATIENTS AND METHODS: We retrospectively analyzed 41 patients with PNEN who were treated at the University Hospital Marburg between 2000 and 2013...
December 22, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28012880/kiaa1199-cemip-hybid-overexpression-predicts-poor-prognosis-in-pancreatic-ductal-adenocarcinoma
#8
Atsuhiro Koga, Norihiro Sato, Shiro Kohi, Kei Yabuki, Xiao-Bo Cheng, Masanori Hisaoka, Keiji Hirata
BACKGROUND: KIAA1199 (also known as CEMIP or HYBID), a newly identified protein involved in hyaluronan degradation, has been suggested to play a critical role in cancer progression. The aim of this study was to investigate the expression and functional significance of KIAA1199 in pancreatic ductal adenocarcinoma (PDAC). METHODS: Using quantitative real-time RT-PCR, we analyzed KIAA1199 mRNA expression in 6 PDAC cell lines and frozen tissues from 14 patients with PDAC...
December 18, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28027898/lower-plasma-levels-of-glucose-dependent-insulinotropic-peptide-gip-and-pancreatic-polypeptide-pp-in-patients-with-ductal-adenocarcinoma-of-the-pancreas-and-their-relation-to-the-presence-of-impaired-glucoregulation-and-weight-loss
#9
Jan Škrha, Petr Bušek, Jana Uhrová, Petr Hrabal, Klára Kmochová, Martin Laclav, Bohuš Bunganič, Přemysl Frič
BACKGROUND: The changes in gastrointestinal hormones associated with pancreatic ductal adenocarcinoma (PDAC) in patients with impaired glucoregulation have yet to be evaluated. The aim of this study was to determine plasma concentrations of selected gastrointestinal hormones in PDAC patients with and without diabetes and to compare them with levels found in Type 2 diabetic patients without cancer. METHODS: In this study we examined plasma concentrations of glucose-dependent insulinotropic peptide (GIP), glucagon-like peptide 1 (GLP-1), pancreatic polypeptide (PP), peptide YY (PYY) and neuropeptide Y (NPY), and cytokines leptin and adiponectin in 94 patients with histologically confirmed PDAC...
December 15, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28007459/endothelial-markers-are-associated-with-pancreatic-necrosis-and-overall-prognosis-in-acute-pancreatitis-a-preliminary-cohort-study
#10
Yizhe Chen, Lu Ke, Lei Meng, Qi Yang, Zhihui Tong, Yiyuan Pan, Weiqin Li, Jieshou Li
BACKGROUND: Endothelial injury is believed to play an important role in the evolution of pancreatic microcirculatory dysfunction and pancreatic necrosis (PN) in patients with acute pancreatitis (AP). The aim of this study was to investigate the role of three endothelial markers (von Willebrand factor, vWF; E-selectin; endothelial protein C receptor, EPCR) in the early phase of AP, especially the relationship between endothelial markers and PN. METHODS: From March 2015 to March 2016, 57 AP patients admitted within 72 h of symptom onset in our hospital were included for this study...
December 15, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28027896/international-consensus-for-the-treatment-of-autoimmune-pancreatitis
#11
Kazuichi Okazaki, Suresh T Chari, Luca Frulloni, Markus M Lerch, Terumi Kamisawa, Shigeyuki Kawa, Myung-Hwan Kim, Philippe Lévy, Atsushi Masamune, George Webster, Tooru Shimosegawa
BACKGROUND AND AIMS: The International Consensus Diagnostic Criteria (ICDC) for AIP has proposed two distinctive type of AIP, type 1 and type 2, and enabled us first to differentiate two types of AIP each other. By initial steroid treatment for induction of remission, remission can be successfully induced in almost all subjects with type 1 and type 2 AIP. As relapse rate in type 1 AIP is significantly higher than in type 2 AIP, there has been ongoing debate on how to treat effectively relapse of type 1 AIP...
December 12, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/27979602/association-between-serum-span-1-and-lymph-node-metastasis-in-invasive-intraductal-papillary-mucinous-neoplasm-of-the-pancreas
#12
Kodai Yamanaka, Atsuhiro Masuda, Hirochika Toyama, Hideyuki Shiomi, Yoh Zen, Keitaro Sofue, Mamoru Takenaka, Takashi Kobayashi, Arata Sakai, Yosuke Yagi, Takashi Nakagawa, Masaru Yoshida, Yoshifumi Arisaka, Yoshihiro Okabe, Hiromu Kutsumi, Takumi Fukumoto, Yonson Ku, Takeshi Azuma
BACKGROUND AND AIM: Lymph node metastasis predicts poorer prognoses in patients with invasive intraductal papillary mucinous neoplasms of the pancreas (IPMNs). Factors associated with lymph node metastasis of invasive IPMN remain unclear. Therefore, this study aimed to define factors associated with lymph node metastasis of invasive IPMN. METHODS: Between June 2000 to August 2015, 156 consecutive patients with IPMN underwent surgical resection at Kobe University Hospital, and were enrolled in this study...
December 10, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28043760/endoscopic-ultrasonography-complements-computed-tomography-in-predicting-portal-or-superior-mesenteric-vein-resection-in-patients-with-borderline-resectable-pancreatic-carcinoma
#13
Evan S Glazer, Omar M Rashid, Jason B Klapman, Cynthia L Harris, Pamela J Hodul, Jose M Pimiento, Mokenge P Malafa
BACKGROUND: Current guidelines recommend computed tomographic (CT) scans for vascular staging of patients with pancreatic carcinoma; however, endoscopic ultrasonography (EUS) in these patients is not required and its utility in combination with CT scan is less well-defined. The purpose of this study is to explore the utility of EUS in addition to CT in identifying patients with borderline resectable pancreatic carcinoma (BRPC). METHODS: We reviewed our database of patients with BRPC who went to surgery with curative intent...
December 5, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/27939603/acyl-free-carnitine-ratio-is-a-risk-factor-for-hepatic-steatosis-after-pancreatoduodenectomy-and-total-pancreatectomy
#14
Masafumi Nakamura, Kohei Nakata, Hideo Matsumoto, Takao Ohtsuka, Koji Yoshida, Shoji Tokunaga, Keisuke Hino
OBJECTIVES: Hepatic steatosis, one of the most frequent long-term complications of pancreatectomy, influences not only hepatic function but also survival rate. However, its risk factors and pathogenesis have not been established. The purpose of this study was to clarify the risk factors for hepatic steatosis after pancreatectomy. METHODS: In this retrospective study of 21 patients who had undergone pancreatectomy (19 cases of pancreatoduodenectomy and 2 cases of total pancreatectomy), serum carnitine concentrations, fractions of carnitine, and hepatic attenuation on computed tomography images were analyzed with the aim of identifying risk factors for hepatic steatosis...
December 1, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/27916415/hospital-discharges-and-patient-activity-associated-with-chronic-pancreatitis-in-ireland-2009-2013
#15
Hazel M Ní Chonchubhair, Yasir Bashir, David McNaughton, Joseph M Barry, Sinead N Duggan, Kevin C Conlon
OBJECTIVE: To investigate trends in acute public hospital patient discharges in Ireland, to analyse hospital discharge activity for geographical variations, aetiological differences, and to estimate a national prevalence for chronic pancreatitis. METHOD: We performed a nationwide retrospective study of all in-patient discharges from acute public hospitals in Ireland, participating in the Hospital In-Patient Enquiry (HIPE) reporting system. We searched for International Classification of Disease, Tenth Revision, Australian Modification (ICD-10-AM) codes K86...
November 25, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/27914940/soluble-urokinase-type-plasminogen-activator-receptor-supar-in-patients-with-acute-pancreatitis-ap-progress-in-prediction-of-ap-severity
#16
Michal Lipinski, Alicja Rydzewska-Rosolowska, Andrzej Rydzewski, Malgorzata Cicha, Grazyna Rydzewska
BACKGROUND: Soluble urokinase-type plasminogen activator receptor (suPAR) is a glycoprotein secreted during inflammation and infections. Moreover, increased levels of suPAR are observed after hypoxia and ischaemia. The aim of the study was to assess whether suPAR could represent a useful marker of acute pancreatitis (AP) severity. PATIENTS AND METHODS: We have observed a cohort of 126 prospectively enrolled patients. Based on the presence of persistent organ failure (more than 48 h) and local complications (diagnosis of moderate AP [MSAP]), patients were classified into three groups: mild AP (MAP), moderate and severe AP (SAP)...
November 25, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/27899271/the-role-of-transpapillary-drainage-in-management-of-patients-with-pancreatic-fluid-collections-and-pancreatic-duct-disruption-as-a-consequences-of-severe-acute-pancreatitis
#17
EDITORIAL
Mateusz Jagielski, Marian Smoczyński, Krystian Adrych
In last thirty years we have been observing significant development of an endoscopic treatment of pancreatic fluid collections, including transmural drainage of walled-off pancreatic necrosis. Simultaneously, the use of endotherapy in treatment of main pancreatic ducts disruptions has increased. Despite many publications available in current literature, concerning the endoscopic treatment of consequences of acute necrotizing pancreatitis, the role of transpapillary drainage in management of patients with pancreatic fluid collections and pancreatic duct disruption as an after-effect of severe acute pancreatitis remains unclear and is still a current problem...
November 18, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/27889422/symptomatic-pancreatic-duct-stones-in-the-disconnected-bile-duct-a-case-series
#18
Alexander R Ende, Shayan Irani, Richard A Kozarek
BACKGROUND: Pancreaticobiliary maljunction (PBM) refers to the union of the pancreatic and biliary ducts outside of the duodenal wall. Patients are at increased risk of bile duct and gallbladder cancer, likely secondary to pancreatic juice refluxing into the biliary tree, and it is recommended that they undergo biliary diversion. METHODS: This is a case series of all patients in our institution with PBM and bilioenteric anastomosis who presented with symptomatic pancreatic duct stones in a disconnected bile duct...
November 14, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/27840175/prognostic-significance-of-intraoperative-peritoneal-washing-cytology-for-patients-with-potentially-resectable-pancreatic-ductal-adenocarcinoma
#19
Sojun Hoshimoto, Shoichi Hishinuma, Hirofumi Shirakawa, Moriaki Tomikawa, Iwao Ozawa, Nobuo Hoshi, Sayuri Hoshi, Kaoru Hirabayashi, Yoshiro Ogata
BACKGROUND: The prognostic significance of intraoperative peritoneal washing cytology (IPWC) in pancreatic ductal adenocarcinoma (PDAC) remains controversial, and the treatment strategy for PDAC patients with positive cytology has not been established. OBJECTIVES: The objective of this study was to evaluate the clinical significance of IPWC in PDAC patients. METHODS: This study included a retrospective cohort of 166 patients with curatively resected PDAC who underwent IPWC...
November 7, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/27838258/outcome-of-pancreas-transplantation-from-donation-after-circulatory-death-compared-to-donation-after-brain-death
#20
REVIEW
Ellen S van Loo, Christina Krikke, Hendrik S Hofker, Stefan P Berger, Henri G D Leuvenink, Robert A Pol
INTRODUCTION: To overcome the gap of organ shortage grafts from donation after circulatory death (DCD) can be used. This review evaluates the outcomes after DCD pancreas donation compared to donation after brain death (DBD). MATERIALS AND METHODS: A literature search was performed using Medline, Embase, and PubMed databases. All comparative cohort studies reporting the outcome after DCD and DBD pancreas transplantation were included. All data were assessed according to the Meta-analysis of Observational Studies in Epidemiology (MOOSE) guidelines...
November 7, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
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