journal
MENU ▼
Read by QxMD icon Read
search

Reproduction: the Official Journal of the Society for the Study of Fertility

journal
https://www.readbyqxmd.com/read/30087159/indoleamine-2-3-dioxygenase-suppresses-the-cytotoxicity-of-1-nk-cells-in-response-to-ectopic-endometrial-stromal-cells-in-endometriosis
#1
Xuan-Tong Liu, Hui-Ting Sun, Zhong-Fang Zhang, Ru-Xia Shi, Li-Bing Liu, Jia-Jun Yu, Wen-Jie Zhou, Chun-Jie Gu, Shao-Liang Yang, Yu-Kai Liu, Hui-Li Yang, Feng-Xuan Xu, Ming-Qing Li
It has been reported that the impaired cytotoxicity of natural killer (NK) cells and abnormal cytokines that are changed by the interaction between ectopic endometrial cells and immune cells is indispensable for the initiation and development of endometriosis (EMS). However, the mechanism of NK cells dysfunction in EMS remains largely unclear. Here, we found that NK cells in peritoneal fluid from women with EMS highly expressed indoleamine 2,3-dioxygenase (IDO). Furthermore, IDO+NK cells possessed lower NKp46 and NKG2D but higher IL-10 than that of IDO-NK...
August 7, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/30072572/luteal-angpt-tie-system-during-selected-stages-of-pregnancy-and-normal-and-antigestagen-induced-luteolysis-in-the-dog
#2
Aykut Gram, Miguel Tavares Pereira, Alois Boos, Anna T Grazul-Bilska, Mariusz P Kowalewski
Rapid establishment of a vascular network is essential for normal functionality of the corpus luteum (CL). The early luteal phase is associated with increased expression of the VEGF-system in canine CL. Acting in synchrony with angiopoietins (ANGPTs), VEGF-system plays major roles in stabilization of blood vessels. However, the expression of the ANPGT-system has not yet been investigated in the dog. Therefore, here, we investigated the luteal expression of ANGPT1, -2, and of their receptors TIE1 and -2, in pregnant dogs at selected time points during pregnancy and at normal and antigestagen-induced luteolysis...
August 2, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/30072571/retinoid-signaling-controlled-by-src-2-in-decidualization-revealed-by-transcriptomics
#3
Maria Magdalena Szwarc, Lan Hai, William E Gibbons, Lisa D White, Qianxing Mo, Ramakrishna Kommagani, Rainer B Lanz, Francesco J DeMayo, Bert W O'Malley, John P Lydon
Establishment of a successful pregnancy requires not only implantation of a healthy embryo into a receptive uterus but also progesterone receptor (PGR)-dependent transformation of endometrial stromal cells (ESCs) into specialized decidual cells. Decidual cells support the developing embryo and are critical for placentation. We have previously shown that a known transcriptional coregulator of the PGR, Steroid Receptor Coactivator-2 (SRC-2), is a critical driver of endometrial decidualization in both human and mouse endometrium...
August 2, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/30054331/myostatin-is-expressed-in-bovine-ovarian-follicles-and-modulates-granulosal-and-thecal-steroidogenesis
#4
Warakorn Cheewasopit, Mhairi Laird, Claire Glister, Philip G Knight
Myostatin plays a negative role in skeletal muscle growth regulation but its potential role in the ovary has received little attention. Here, we first examined relative expression of myostatin (MSTN), myostatin receptors (ACVR1B, ACVR2B and TGFBR1) and binding protein, follistatin (FST), in granulosa (GC) and theca (TC) cells of developing bovine follicles. Secondly, using primary GC and TC cultures, we investigated whether myostatin affects steroidogenesis and cell number. Thirdly, effects of gonadotropins and other factors on MSTN expression in GC and TC were examined...
July 27, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/30054330/pgrmc1-2-promote-luteal-vascularization-and-maintain-the-primordial-follicles-of-mice
#5
John J Peluso, Xiufang Liu, Tracy Uliasz, Cindy A Pru, Nicole C Kelp, James Pru
To determine whether conditional depletion of Progesterone Receptor Membrane Component (PGRMC) 1 and PGRMC2 affected ovarian follicle development, follicle distribution was assessed in ovaries of young (≈ 3 month-old) and middle-aged (≈6 month-old) control (Pgrmc1/2fl/fl) and double conditional PGRMC1/2 knockout (Pgrmc1/2d/d) mice. This study revealed that the distribution of primary, preantral and antral follicles was not altered in Pgrmc1/2d/d mice, regardless of the age. Although the number of primordial follicles was similar at ≈ 3 months of age, their numbers were reduced by ≈ 80% in 6-month old Pgrmc1/2d/d mice compared to age-matched Pgrmc1/2fl/fl mice...
July 27, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/30037984/transposons-and-the-piwi-pathway-genome-defence-in-gametes-and-embryos
#6
Stewart J Russell, Jonathan LaMarre
Hiding in plain sight within the genome of virtually every eukaryotic organism are large numbers of sequences known as transposable elements (TEs). These sequences often comprise 50% or more of the DNA in many mammals and are transcriptionally constrained by DNA methylation and repressive chromatin marks. Individual TEs, when relieved of these epigenetic constraints, can readily move from one genomic location to another, either directly or through RNA intermediates. Demethylation and removal of repressive histone marks during epigenetic reprogramming stages of gametogenesis and embryogenesis render the genome particularly susceptible to increased TE mobilization, which has significant implications for the fidelity of genome replication and subsequent viability of the progeny...
July 23, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/30021913/blastocyst-induced-changes-in-the-bovine-endometrial-transcriptome
#7
Claudia Passaro, Desmond Tutt, Daniel J Mathew, Jose Maria Sanchez, John A Browne, Gry Boe-Hansen, Trudee Fair, Pat Lonergan
The objectives of this study were (i) to determine whether blastocyst-induced responses in endometrial explants were detectable after 6 or 24 h co-culture in vitro; (ii) to test if direct contact is required between embryos and the endometrial surface in order to stimulate endometrial gene expression; (iii) to establish the number of blastocysts required to elicit a detectable endometrial response; (iv) to investigate if upregulation of five interferon-stimulated genes (ISGs) in the endometrium was specific to the blastocyst stage; and (v) to test if alterations in endometrial gene expression can be induced by blastocyst-conditioned medium...
July 18, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/30006439/irf5-is-increased-in-laboring-myometrium-and-regulates-pro-labor-mediators
#8
Ratana Lim, Gillian Barker, Martha Lappas
Preterm birth continues to be the leading cause of neonatal mortality and morbidities that can extend into adult life. Few treatment options stem from our incomplete understanding of the mechanisms of human labor and delivery. Activation of the inflammatory response in gestational tissues by inflammation and/or infection leads to the production of pro-inflammatory and pro-labor mediators, thus preterm birth. Interferon regulatory factor 5 (IRF5) has recently emerged as an important pro-inflammatory transcription factor involved in acute and chronic inflammation...
July 13, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/30006438/maternal-nutrition-and-reproductive-functions-of-female-and-male-offspring
#9
Ziya Kalem, Muberra Namli Kalem, Elvan Anadol, Batuhan Bakirarar, Canan Yilmaz, Cigdem Elmas, Perihan Yalcinkaya, Halil Ruso, Timur Gurgan
This study aimed to investigate the effects of maternal unhealthy nutrition on the reproductive functions of female and male adult offspring. This was an animal study carried out with 24 virgin female Wistar rats(dams) and their male and female offspring. Rats were divided standard diet (SD) or cafeteria diet (CD) groups, after 10 weeks of feeding, all rats were paired with a Wistar stud male, and each group was again divided into CD and SD groups during the pregnancy and lactation periods. After birth, 6 female and 6 male pups in each group, were subjected to study...
July 13, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/30006437/gata4-is-a-negative-regulator-of-contractility-in-testicular-peritubular-myoid-cells
#10
Yu-Qian Wang, Aalia Batool, Su-Ren Chen, Yi-Xun Liu
Reduced contractility of the testicular peritubular myoid (PTM) cells may contribute to human male sub- or infertility. Transcription factor GATA4 in Sertoli and Leydig cells is essential for murine spermatogenesis; but limited attention has been paid to the potential role of GATA4 in PTM cells. In primary cultures of mouse PTM cells, siRNA knockdown of GATA4 increased the contractile activity, while GATA4 overexpression significantly attenuated the contractility of PTM cells using a collagen gel contraction assay...
July 13, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29991568/the-role-of-intragestational-ghrelin-on-postnatal-development-and-reproductive-programming-in-mice
#11
Pedro Javier Torres, Eugenia Mercedes Luque, Marina Flavia Ponzio, Verónica Cantarelli, Marcela Diez, Silvia Figueroa, Laura Maria Vincenti, Valeria Paola Carlini, Ana Carolina Martini
The purpose of this study was to evaluate the intragestational role of ghrelin in offspring development and reproductive programming in a mouse model of ghrelin imbalance during pregnancy. Female mice were injected with ghrelin (supraphysiological levels: 4 nmol/animal/day), antagonist (endogenous ghrelin inhibition with (D-Lys3)GHRP-6, 6 nmol/animal/day) or vehicle (control=normal ghrelin levels) throughout the pregnancy. Parameters evaluated in litters were growth, physical, neurobiological, and sexual development and, at adulthood, reproductive function...
July 10, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29991567/dynamic-changes-in-gene-expression-and-signalling-during-trophoblast-development-in-the-horse
#12
Jordan E Read, Victoria Cabrera-Sharp, Victoria Offord, Samantha M Mirczuk, Steve P Allen, Robert C Fowkes, Amanda M de Mestre
Equine chorionic girdle trophoblast cells play important endocrine and immune functions critical in supporting pregnancy. Very little is known about the genes and pathways that regulate chorionic girdle trophoblast development. Our aim was to identify genes and signalling pathways active in vivo in equine chorionic girdle trophoblast within a critical 7 days window. We exploited the late implantation of the equine conceptus to obtain trophoblast tissue. An Agilent equine 44K microarray was performed using RNA extracted from Chorionic Girdle and Chorion (control) from equine pregnancy days 27, 30, 31 and 34 (n=5), corresponding to the initiation of chorionic girdle trophoblast proliferation, differentiation and migration...
July 10, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29991566/maternal-low-protein-diet-programmes-low-ovarian-reserve-in-offspring
#13
Amy L Winship, Sarah E Gazzard, Luise A Cullen McEwen, John F Bertram, Karla J Hutt
The ovarian reserve of primordial follicle oocytes is formed during in utero development and represents the entire supply of oocytes available to sustain female fertility. Maternal undernutrition during pregnancy and lactation diminishes offspring ovarian reserve in rats. In mice, maternal oocyte maturation is also susceptible to undernutrition, causing impaired offspring cardiovascular function. We aimed to determine whether programming of the ovarian reserve is impacted in offspring when maternal undernutrition extends from preconception oocyte development through to weaning...
July 10, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29967283/role-of-early-life-nutrition-on-the-hypothalamic-pituitary-testicular-axis-of-the-bull
#14
Anne-Marie English, David A Kenny, Colin J Byrne, Helga Sauerwein, Christiane Urh, Mark A Crowe, Christophe Staub, Sinead Maria Waters, S Fair
The objective of this study was to examine the effect of nutrition during the first 18 weeks of life on the physiological and transcriptional functionality of the hypothalamic, anterior pituitary and testes in Holstein Friesian bull calves. Holstein Friesian bull calves with a mean (±S.D.) age and bodyweight of 19 (±8.2) days and 47.5 (±5.3) kg, respectively, were assigned to either a HIGH (n=10) or LOW (n=10) plane of nutrition, to achieve an overall target growth rate of 1.2 or 0.5 kg/day, respectively...
July 2, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29941464/programming-of-the-reproductive-axis-by-hormonal-and-genetic-manipulation-in-mice
#15
Susana B Rulli, María Julia Cambiasso, Laura D Ratner
In mammals, the reproductive function is controlled by the hypothalamic-pituitary-gonadal axis. During development, mechanisms mediated by gonadal steroids exert an imprinting at the hypothalamic-pituitary level, by establishing sexual differences in the circuits that control male and female reproduction. In rodents, the testicular production of androgens increases drastically during the fetal/neonatal stage. This process is essential for the masculinization of the reproductive tract, genitals and brain. The conversion of androgens to estrogens in the brain is crucial for the male sexual differentiation and behavior...
June 25, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29930176/cftr-is-required-for-the-migration-of-primordial-germ-cells-during-zebrafish-early-embryogenesis
#16
Huijuan Liao, Yan Chen, Li Yulong, Shaolong Xue, Mingfeng Liu, Ziyuan Lin, Yanyan Liu, Hsiao Chang Chan, Xiaohu Zhang, Huaqin Sun
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene affect fertility in both sexes. However, the involvement of CFTR in regulating germ cell development remains largely unknown. Here, we used zebrafish model to investigate the role of CFTR in primordial germ cells (PGCs) development. We generated a cftr frameshift mutant zebrafish line using CRISPR/Cas9 technique and investigated the migration of PGCs during early embryo development. Our results showed that loss of Cftr impairs the migration of PGCs from dome stages onwards...
June 21, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29921626/activated-farnesoid-x-receptor-fxr-expressed-in-human-sperm-alters-its-fertilizing-ability
#17
Rocco Malivindi, Marta Santoro, Daniela De Rose, Salvatore Panza, Serena Gervasi, Vittoria Rago, Saveria Aquila
The farnesoid X receptor alpha (FXR) is a bile acid sensor activated by binding to endogenous bile acids including chenodeoxycholic acid (CDCA). Although, FXR is expressed in male reproductive tissue, the relevance of the receptor on reproduction is scarcely known. Here we demonstrated the FXR presence and its action on several human sperm features. Western blot and Immunofluorescence assays evidenced the FXR expression in human spermatozoa and the localization in the middle piece. CDCA increasing concentrations and GW4064, synthetic ligand of FXR, were used to study the FXR influence on sperm motility, survival, capacitation, acrosome reaction and on glucose as well as lipid metabolism...
June 19, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29921625/genomic-integrity-in-the-male-germ-line-evidence-in-support-of-the-disposable-soma-hypothesis
#18
Miguel J Xavier, Lisa A Mitchell, Kristen E McEwan, Rodney Scott, Robert John Aitken
The Big Blue® λSelect-cII selection system has been employed along with whole-exome sequencing, to examine the susceptibility of the male germ line to mutation in two challenging situations: (i) exposure to a chemotherapeutic regime including bleomycin, etoposide and cis-platinum (BEP) and (ii) the ageing process. A 3-week exposure to BEP induced complete azoospermia associated with a loss of developing germ cells and extensive vacuolization of Sertoli cell cytoplasm. Following cessation of treatment, spermatozoa first appeared in the caput epididymis after 6 weeks and by 12 weeks motile spermatozoa could be recovered from the cauda, although the count (P < 0...
June 19, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29907662/expression-of-atresia-biomarkers-in-granulosa-cells-after-ovarian-stimulation-in-heifers
#19
David A Landry, Lia Rossi-Perazza, Simon Lafontaine, Marc-Andre Sirard
The use of younger gamete donors in dairy cattle genetic selection programs significantly accelerates genetic gains by decreasing the interval between generations. Ovarian stimulation and the practice of follicle-stimulating hormone (FSH) withdrawal, also known as coasting, are intensively used in pre-pubertal heifers without detrimental effects on subsequent reproductive performance but generally with lower embryo yields. However, recent data from embryo transfer programs showed similar embryo yields in younger and sexually mature animals but with a significant difference in the coasting period...
June 15, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29907661/nlrp3-in-somatic-non-immune-cells-of-rodent-and-primate-testes
#20
Lena Walenta, Nina Schmid, J U Schwarzer, Frank-Michael Köhn, Henryk Urbanski, Ruediger Behr, Leena Strauss, Matti Poutanen, Artur Mayerhofer
NLRP3 is part of the NLRP3 inflammasome and a global sensor of cellular damage. It was recently discovered in rodent Sertoli cells. We investigated NLRP3 in mouse, human and non-human primate (marmoset and rhesus macaque) testes, employing immunohistochemistry. Sertoli cells of all species expressed NLRP3, and the expression preceded puberty. In addition, peritubular cells of the adult human testes expressed NLRP3. NLRP3 and associated genes (ASC, CASP1, IL1B) were also found in isolated human testicular peritubular cells (HTPCs) and the mouse Sertoli cell line TM4...
June 15, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
journal
journal
35194
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"