journal
https://read.qxmd.com/read/38471307/current-insights-and-a-potential-role-of-nad-in-the-reproductive-health-of-aging-fathers-and-their-children
#1
REVIEW
Morgan B Feuz, David Colton Nelson, Laura B Miller, Alexie E Zwerdling, R G Meyer, Mirella L Meyer-Ficca
In brief: In light of the increasing age of first-time fathers, this article summarizes the current scientific knowledge base on reproductive aging in the male, including sperm quality and health impacts for the offspring. The emerging role of NAD decline in reproductive aging is highlighted. Abstract: Over the past decades, the age of first-time fathers has been steadily increasing due to socio-economic pressures. While general mechanisms of aging are subject to intensive research, male reproductive aging has remained an understudied area, and the effects of increased age on the male reproductive system are still only poorly understood, despite new insights into the potential dire consequences of advanced paternal age for the health of their progeny...
March 1, 2024: Reproduction
https://read.qxmd.com/read/38471304/inhibition-of-hsp90aa1-induces-abnormalities-in-bovine-oocyte-maturation-and-embryonic-development
#2
JOURNAL ARTICLE
Baobao Zhao, Heqiang Li, Han Zhang, Xin Rui Lan, Xingchen Ren, Liangyi Zhang, Huiming Ma, Yong Zhang, Yongsheng Wang
In brief: HSP90AA1 is a ubiquitous molecular chaperone that can resist cellular stress, such as oxidative stress and apoptosis, and mediate the efficacy and protein folding of normal cells during heat stress, as well as many other functions. This study further reveals the role of HSP90AA1 in bovine oocytes maturation and early embryonic development. Abstract: HSP90AA1, a highly abundant and ubiquitous molecular chaperone, plays important roles in various cellular processes including cell cycle control, cell survival, and hormone signaling pathways...
March 1, 2024: Reproduction
https://read.qxmd.com/read/38467105/congenital-zika-virus-infection-impacts-on-male-mice-offspring-s-reproductive-biology
#3
JOURNAL ARTICLE
Natália Teixeira Wnuk, André Felipe Almeida Figueiredo, Talita De Oliveira Farias, Marcos Rocha Gouvêa Brener, Samyra Maria Dos Santos Nassif Lacerda, Vidyleison Neves Camargos, Paulo Henrique Amaral, Lidia Maria Andrade, Maria Ivonete Nogueira Silva, Roberta Araujo Lopes, Raphael Escorsim Szawka, Juan Carlos González, Mauro Martins Teixeira, Danielle da Glória Souza, Vivian Vasconcelos Costa, Guilherme Mattos Jardim Costa
Infection with ZIKV during pregnancy is associated with fetal developmental problems. Although neurological issues are being explored more in experimental studies, limited research has focused on the reproductive health consequences for offspring born to infected mothers. In this context, this study aimed to assess the impact of ZIKV infection during pregnancy on the testes and sperm of adult male offspring. Female mice were intraperitoneally inoculated with a Brazil strain of ZIKV during the 5.5th day of embryonic gestation...
March 1, 2024: Reproduction
https://read.qxmd.com/read/38457920/naked-mole-rat-ovaries-allow-investigation-of-ovarian-reserve-in-vitro-germ-cell-expansion-and-oocyte-ivm-within-a-single-sample
#4
REVIEW
Gretchen M Rosado, Ana Martinez-Marchal, Mariela Faykoo-Martinez, Melissa M Holmes, Miguel Angel Angel Brieño-Enriquez
Recently, we described that in the naked mole-rat ovary it is possible to study the ovarian reserve and the mitotic expansion of the germ cell postnatally. Herein, we show oocyte in vitro maturation and in vitro germ cell expansion using the same ovary.
March 1, 2024: Reproduction
https://read.qxmd.com/read/38451876/oviduct-and-endometrial-epithelium-improve-in-vitro-produced-bovine-embryo-developmental-kinetics
#5
JOURNAL ARTICLE
L Kirsten Senn, Katheryn D Peterson, J Lannett Edwards, Rebecca R Payton, Daniel J Mathew
In vitro embryo production in cattle greatly impacts blastomere biochemistry, embryo rate of development and pre- and post-transfer survival. In vivo, the bovine embryo migrates through the oviduct isthmus before entering the uterus on approximately Day 4 of development where it remains unattached within the uterine lumen until Day 20 of gestation. During this time, the embryo is sequentially exposed to oviduct followed by endometrial secretions that support embryonic development. Considering this, we tested the effect of culturing in vitro produced (IVP) bovine embryos sequentially in oviduct epithelial (OEp; Days 1-3) followed by endometrial epithelial (EEp) or EEp and fibroblast cell (EEp/F; Days 4-8) conditioned media on embryonic development using a time lapse monitoring system...
March 1, 2024: Reproduction
https://read.qxmd.com/read/38451875/impaired-fertility-in-adenomyosis-a-murine-model-reveals-endometrial-receptivity-and-progesterone-resistance-imbalances
#6
JOURNAL ARTICLE
Marlyne Squatrito, Julie Vervier, Jules Bindels, Laëtitia Bernet, Silvia Blacher, Michelle Nisolle, Carine Munaut
This study investigates the intricate relationship between adenomyosis and reproductive health using a murine model, offering novel insights into this prevalent gynecological disorder. Adenomyosis, characterized by the invasive growth of endometrial tissue into the myometrium, is believed to negatively impact fertility. However, the challenge lies in disentangling this influence, as adenomyosis often coexists with other gynecological diseases. A tamoxifen-induced mice model presents a significant advantage by enabling the specific study of adenomyosis, devoid of confounding influences of concurrent gynecological diseases such as endometriosis...
March 1, 2024: Reproduction
https://read.qxmd.com/read/38451874/peroxisome-proliferator-activated-receptors-and-placental-function-in-women-with-polycystic-ovary-syndrome
#7
REVIEW
Aimé Silva, Alicia Motta
Polycystic ovary syndrome (PCOS) is one of the major endocrine disorders affecting women during their reproductive ages. Given its association with other pathologies, such as insulin resistance, metabolic syndrome, type 2 diabetes and obesity, women with PCOS could present high-risk pregnancies, including a high abortion rate, implantation failure, an increased risk of gestational diabetes, preeclampsia, and intrauterine growth restriction. These adverse pregnancy outcomes are often attributed, at least in part, to defects in placental functions...
March 1, 2024: Reproduction
https://read.qxmd.com/read/38428139/isolation-of-serum-derived-placental-amniochorionic-extracellular-vesicles-across-pregnancy-by-immunoaffinity-using-plap-and-hla-g
#8
JOURNAL ARTICLE
Uma Shinde, Aishwarya Rao, Vandana Bansal, Dhanjit Kumar Das, Nafisa Huseni Balasinor, Taruna Madan
Extracellular vesicles (EVs) are membrane-bound nanovesicles secreted from the cells into extracellular space and body fluids. They are considered "fingerprints of parent cells" which can reflect their physiological and functional states. During pregnancy, extracellular vesicles (EVs) are produced by the syncytiotrophoblasts and extravillous trophoblasts and are released into the maternal bloodstream. In the present study, placental alkaline phosphatase (PLAP)-specific extracellular vesicles were isolated from maternal serum-derived EVs (SDE) across pregnancy...
February 1, 2024: Reproduction
https://read.qxmd.com/read/38401264/spindle-shape-and-volume-differ-in-high-and-low-quality-metaphase-ii-oocytes
#9
JOURNAL ARTICLE
Monika Fluks, Robert Milewski, Szymon Tamborski, Maciej Szkulmowski, Anna Ajduk
The proper development of embryos strongly depends on the quality of oocytes, so the evaluation of oocytes may be a useful initial step in in vitro fertilization procedures. Additionally, it enables embryologists to make more informed decisions regarding the treatments chosen for the patients and better manage patients' expectations. Optical coherence microscopy (OCM) allows for non-invasive 3D visualization of intracellular structures, such as spindles or nuclei, which have been linked to the success of embryonic development...
February 1, 2024: Reproduction
https://read.qxmd.com/read/38401263/the-n-terminal-modification-of-hormad2-causes-its-ectopic-persistence-on-synapsed-chromosomes-without-meiotic-blockade
#10
JOURNAL ARTICLE
Isabella G Cossu, N Adrian Leu, Yongjuan Guan, P Jeremy Wang
During meiosis, homologous chromosomes undergo synapsis and recombination. HORMA domain proteins regulate key processes in meiosis. Mammalian HORMAD1 and HORMAD2 localize to unsynapsed chromosome axes but are removed upon synapsis by the TRIP13 AAA+ ATPase. TRIP13 engages the N-terminal region of HORMA domain proteins to induce an open conformation, resulting in disassembly of protein complexes. Here we report introduction of a 3×FLAG-HA tag to the N-terminus of HORMAD2 in mice. Co-immunoprecipitation coupled with mass spectrometry identified HORMAD1 and SYCP2 as HORMAD2-associated proteins in testis...
February 1, 2024: Reproduction
https://read.qxmd.com/read/38377683/paternal-protein-provisioning-to-embryos-during-male-seahorse-pregnancy
#11
JOURNAL ARTICLE
Zoe Skalkos, James Van Dyke, Samson Dowland, Camilla Whittington
Syngnathid embryos (seahorses, pipefishes, and seadragons) develop on or in the male in a specialised brooding structure (brood pouch). Seahorse brood pouches supply nutrients, including lipids, to developing embryos (patrotrophy). We tested the hypothesis that proteins, vital for gene regulation and tissue growth during embryogenesis, are also transported from father to embryos, using the Australian pot-bellied seahorse, Hippocampus abdominalis. We used dry masses and total nitrogen content to estimate total protein content of newly fertilised egg and neonate H...
February 1, 2024: Reproduction
https://read.qxmd.com/read/38271822/the-central-role-of-pyruvate-metabolism-on-the-epigenetic-maturation-and-transcriptional-profile-of-bovine-oocytes
#12
JOURNAL ARTICLE
João Vitor Alcantara da Silva, Jessica Ispada, Ricardo Perecin Nociti, Aldcejam Martins da Fonseca Junior, Camila Bruna De Lima, Erika Cristina Dos Santos, Marcos Roberto Chiaratti, Marcella Pecora Milazzotto
Pyruvate, the final product of glycolysis, undergoes conversion into acetyl-CoA within the mitochondria of oocytes, serving as a primary fuel source for the tricarboxylic acid (TCA) cycle. The citrate generated in the TCA cycle can be transported to the cytoplasm and converted back into acetyl-CoA. This acetyl-CoA can either fuel lipid synthesis or act as a substrate for histone acetylation. This study aimed to investigate how pyruvate metabolism influences lysine 9 histone 3 acetylation (H3K9ac) dynamics and RNA transcription in bovine oocytes during in vitro maturation (IVM)...
January 1, 2024: Reproduction
https://read.qxmd.com/read/38271800/endocannabinoid-regulation-in-the-cervix-during-pregnancy-insights-into-molecular-mechanisms-of-premature-labor
#13
JOURNAL ARTICLE
Carolina Marvaldi, Felisa María Herrero Lo Giudice, Clare Johnson, Julieta Schander, Fernando Correa, Maximiliano Cella, Julieta Aisemberg, Ana María Franchi, Heather Bradshaw, Manuel Luis Wolfson
During pregnancy, the main role of the cervix is to isolate the fetus from outside pathogens and maintain the relatively closed system of uterine gestation. Conversely, towards the end of pregnancy, the cervix must be remodeled to increase flexibility and allow the delivery. This process is called cervical remodeling and dysregulation of the process plays a role in premature delivery. The endocannabinoidome plays an important role in several reproductive events, however its function on cervical tissue throughout pregnancy is poorly understood...
January 1, 2024: Reproduction
https://read.qxmd.com/read/38236740/long-lasting-effects-of-the-presence-of-male-siblings-in-utero-on-subsequent-reproductive-performance
#14
REVIEW
Mathieu Douhard, Victor Ronget, Frédéric Douhard
Laboratory studies with rodents indicate that in utero proximity of a female to male foetus can affect female's subsequent reproduction due to elevated testosterone exposure during early development. It remains unknown whether these findings can be generalised to non-laboratory species because the need for caesarean section makes it difficult to determine the intrauterine position outside laboratory conditions. As an alternative, some studies have compared the reproductive performance of individuals born in male-biased litters to those born in female-biased litters...
January 1, 2024: Reproduction
https://read.qxmd.com/read/38236723/decreased-nsd2-impairs-stromal-cell-proliferation-in-human-endometrium-via-reprogramming-h3k36me2
#15
JOURNAL ARTICLE
Chuan-Mei Qin, Xiao-Wei Wei, Jia-Yi Wu, Xue-Qing Liu, Yi Lin
Recurrent implantation failure (RIF) is a formidable challenge in assisted reproductive technology because of its unclear molecular mechanism. Impaired human endometrial stromal cell (HESC) proliferation disrupts the rhythm of the menstrual cycle, resulting in devastating disorders between the embryo and the endometrium. The molecular function of histone methylation enzymes in modulating HESC proliferation remains largely uncharacterized. Herein, we found that the levels of histone methyltransferase nuclear receptor binding SET domain protein 2 (NSD2) and the di-methylation of lysine 36 on histone H3 are decreased significantly in the proliferative-phase endometrium of patients with RIF...
January 1, 2024: Reproduction
https://read.qxmd.com/read/38215284/development-of-polarity-reversed-endometrial-epithelial-organoids
#16
JOURNAL ARTICLE
Vakil Ahmad, Sai Goutham Reddy Yeddula, Bhanu Telugu, Thomas E Spencer, Andrew M Kelleher
The uterine epithelium is composed of a single layer of hormone responsive polarized epithelial cells that line the lumen and form tubular glands. Endometrial epithelial organoids (EEO) can be generated from uterine epithelia and recapitulate cell composition and hormone responses in vitro. As such, the development of EEO represents a major advance for facilitating mechanistic studies in vitro. However, a major limitation for the use of EEO cultured in basement membrane extract and other hydrogels is the inner location of apical membrane, thereby hindering direct access to the apical surface of the epithelium to study interactions with the embryo or infectious agents such as viruses and bacteria...
January 1, 2024: Reproduction
https://read.qxmd.com/read/38215278/the-press-assisted-fusion-scheme-significantly-mitigates-the-quantity-of-hvj-e-required-in-mitochondrial-replacement-techniques
#17
JOURNAL ARTICLE
Meng Ma, Shutian Jiang, Wei Jin, Wenzhi Li, Chen Chen, Kaibo Lin, Xiaoyu Liao, Danjun Li, Yanping Kuang, Qifeng Lyu
In brief: The impact of HVJ-E employed in mitochondrial replacement techniques (MRTs) on embryonic development remains uncertain. This study has exhibited the influence of HVJ-E utilized in MRTs on embryonic development and has devised a novel HVJ-E-induced fusion approach to curtail the amount of HVJ-E employed in MRTs. Abstract: Mitochondrial replacement techniques (MRTs) provide a viable option for women carrying pathogenic mitochondrial DNA (mtDNA) variants to conceive disease-free offspring with a genetic connection...
January 1, 2024: Reproduction
https://read.qxmd.com/read/38206180/tead4-regulates-krt8-and-yap-in-preimplantation-embryos-in-mice-but-not-in-cattle
#18
JOURNAL ARTICLE
Xiaotong Wu, Yan Shi, Bingjie Hu, Panpan Zhao, Shuang Li, Lieying Xiao, Shaohua Wang, Kun Zhang
Tead4, a critical transcription factor expressed during preimplantation development, is essential for the expression of trophectoderm-specific genes in mice. However, the functional mechanism of TEAD4 in mouse preimplantation development and its conservation across mammals remain unclear. Here, we report that Tead4 is a crucial transcription factor necessary for blastocyst formation in mice. Disruption of Tead4 through base editing results in developmental arrest at the morula stage. Additionally, RNA-seq analysis reveals dysregulation of 670 genes in Tead4 knockout embryos...
January 1, 2024: Reproduction
https://read.qxmd.com/read/38205973/investigating-ticagrelor-in-a-preclinical-pipeline-as-a-novel-therapeutic-to-prevent-preterm-birth
#19
JOURNAL ARTICLE
Bridget M Arman, Natalie K Binder, Natasha de Alwis, Sally Beard, Anjali Garg, Tu'uhevaha J Kaitu'u-Lino, Natalie J Hannan
Preterm birth remains a significant global health challenge, affecting approximately 10% of pregnancies and resulting in one million deaths globally every year. Tocolytic agents, used to manage preterm labour, have considerable limitations including lack of efficacy, and adverse side-effects, emphasising the urgent need for innovative solutions. Here, we explore repurposing an antiplatelet cardioprotective drug, ticagrelor, as a potential treatment to prevent preterm birth. Ticagrelor has demonstrated pleiotropic actions beyond platelet inhibition, including relaxant effects on smooth muscle cells and anti-inflammatory effects in models of diabetes and sepsis...
January 1, 2024: Reproduction
https://read.qxmd.com/read/38165360/does-tfap2c-govern-conflicting-cell-fates-in-mouse-preimplantation-embryos
#20
REVIEW
Chad S Driscoll, Jaehwan Kim, Mohamed Ashry, Jason G Knott
TFAP2C is a well-established regulator of the trophoblast lineage in mice and humans, but a handful of studies indicate that TFAP2C may play an important role in pluripotency. Here we hypothesize and provide new evidence that TFAP2C functions as an activator of trophoblast and pluripotency genes during preimplantation embryo development.
January 1, 2024: Reproduction
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