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Reproduction: the Official Journal of the Society for the Study of Fertility

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https://www.readbyqxmd.com/read/29661794/reciprocal-regulation-of-tead4-and-ccn2-for-the-trophectoderm-development-of-the-bovine-blastocyst
#1
Hiroki Akizawa, Ken Kobayashi, Hanako Bai, Masashi Takahashi, Shinjiro Kagawa, Hiroaki Nagatomo, Manabu Kawahara
The first segregation at the blastocyst stage is the symmetry-breaking event to characterize two cell components; namely, inner cell mass (ICM) and trophectoderm (TE). TEA domain transcription factor 4 (TEAD4) is a well-known regulator to determine TE properties of blastomeres in rodent models. However, the roles of bovine TEAD4 in blastocyst development have been unclear. We here aimed to clarify the mechanisms underlining TE characterization by TEAD4 in bovine blastocysts. We first found that the TEAD4 mRNA expression level was greater in TE than in ICM, which was further supported by TEAD4 immunofluorescent staining...
April 16, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29636407/radiation-induced-ovarian-follicle-loss-occurs-without-overt-stromal-changes
#2
Bruce F Kimler, Shawn M Briley, Brian W Johnson, Austin G Armstrong, Susmita Jasti, Francesca E Duncan
Radiation damage due to total body irradiation (TBI) or targeted abdominal radiation can deplete ovarian follicles and accelerate reproductive aging. We characterized a mouse model of low dose TBI to investigate how radiation affects the follicular and stromal compartments of the ovary. A single TBI dose of either 0.1 Gy or 1 Gy (Cesium-137γ was delivered to reproductively adult CD1 female mice, and sham-treated mice served as controls. Mice were sacrificed either 2 weeks or 5 weeks post-exposure, and ovarian tissue was harvested...
April 10, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29636406/the-impact-of-infertility-diagnosis-on-embryo-endometrial-dialogue
#3
Jason C Parks, Blair R McCallie, Alyssa L Patton, Zain A Al-Safi, Alex Polotsky, Darren Griffin, William B Schoolcraft, Mandy G Katz-Jaffe
Initial stages of implantation involve bi-directional molecular cross-talk between the blastocyst and endometrium. This study investigated an association between infertility etiologies, specifically advanced maternal age (AMA) and endometriosis, on the embryo-endometrial molecular dialogue prior to implantation. Co-culture experiments were performed with endometrial epithelial cells (EECs) and cryopreserved day 5 blastocysts (n=41 ≥ Grade 3BB) donated from patients presenting with AMA or endometriosis, compared to fertile donor oocyte controls...
April 10, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29636405/40-years-of-bovine-ivf-in-the-new-genomic-selection-context
#4
Marc-Andre Sirard
The development of a complex technology such as in vitro fertilization (IVF) requires years of experimentation, sometimes comparing several species to learn how to create the right in vitro environment for oocytes, spermatozoa, and early embryos. At the same time, individual species characteristics such as gamete physiology and gamete interaction are recently evolved traits and must be analysed within the context of each species. In the last 40 years since the birth of Louise Brown, IVF techniques progressed and are now used in multiple domestic and non-domestic animal species around the world...
April 10, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29636404/development-of-icsi
#5
Claire L O'Neill, Stephen Chow, Zev Rosenwaks, Gianpiero D Palermo
The first conception outside of the human body that lead to the birth of Louise Brown was a tremendous accomplishment, which opened the door to the utilization of assisted reproductive techniques globally. This brought the understanding that accomplishing life in a dish required several steps, the most obvious being the timing and characteristics of fertilization. It soon became obvious in the 1980's that the most disappointing phenomenon was unexpected and complete fertilization failure. Among the approaches that were attempted to treat male factor infertility, ICSI surfaced as the technique that brought the ratio of the gametes to 1:1 and was also able to grant consistent fertilization and a higher pregnancy rate...
April 10, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29626105/murine-sperm-capacitation-oocyte-penetration-and-decondensation-following-moderate-alcohol-intake
#6
Melisa Sanchez, Vanina Andrea Fontana, Camila Galotto, Maite Cambiasso, Cristian Sobarzo, Lucrecia Calvo, Juan Carlos Calvo, Elisa Cebral
Male chronic alcohol abuse causes testicular failure and infertility. We analyzed the effects of moderate sub-chronic alcohol intake on sperm morphology, capacitation, fertilization and sperm head decondensation. CF-1 male mice were administered 15% ethanol in drinking water for 15 days; control mice received ethanol-free water. Similar patterns of tyrosine phosphorylation were observed in capacitated spermatozoa of control and treated males. Percentage of hyperactivation (H) and spontaneous (SAR) and progesterone-induced (IAR) acrosome reaction significantly decreased at 120 and 150 minutes of capacitation in treated males compared to controls (H: 14...
April 6, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29626104/activation-of-lysosomal-cathepsins-in-pregnant-bovine-leukocytes
#7
Md Abdus Shabur Talukder, Ahmed Zaky Balboula, Takahiro Shirozu, Sung-Woo Kim, Hiroki Kunii, Toshiyuki Suzuki, Tsukino Ito, Koji Kimura, Masashi Takahashi
In ruminants, interferon-tau (IFNT)-mediated expression of interferon-stimulated genes in peripheral blood leukocytes (PBLs) can indicate pregnancy. Recently, type 1 IFN-mediated activation of lysosomes and lysosomal cathepsins (CTSs) was observed in immune cells. This study investigated the status of lysosomal CTSs and lysosomes in PBLs collected from pregnant (P) and non-pregnant (NP) dairy cows, and conducted in vitro IFNT-stimulation of NP blood leukocytes. Blood samples were collected 0, 7, 14, and 18 days post-artificial insemination, and the peripheral blood mononuclear cells (PBMCs) and polymorphonuclear granulocytes (PMNs) separated...
April 6, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29626103/role-of-rab5a-in-fshr-mediated-signal-transduction-in-human-granulosa-cells
#8
Kai Zhu, Shang Li, Jiansheng Liu, Yan Hong, Zi-Jiang Chen, Yanzhi Du
Polycystic ovary syndrome, a common condition characterized by endocrine dysfunction, menstrual irregularity, anovulation, and polycystic ovaries, affects 5%-7% of reproductive-age women. RAB5B, which is identified by a genome-wide association study as a risk locus for this syndrome, encodes a small GTPase involved in control of receptor internalization and early endosome fusion. We found that RAB5A mRNA levels in luteinized granulosa cells of obese patients with polycystic ovary syndrome were lower than in those of obese women without the syndrome...
April 6, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29618635/removal-of-sialic-acid-from-bull-sperm-decreases-motility-and-mucus-penetration-ability-but-increases-zona-pellucida-binding-and-polyspermic-penetration-in-vitro
#9
Beatriz Fernandez-Fuertes, Alfonso Blanco-Fernandez, Colm J Reid, Kieran Meade, S Fair, Pat Lonergan
This study tested the hypothesis that sperm sialic acid (Sia) is required to reach the site of fertilization, and that successful fertilization requires recognition of Sia from both the sperm and oocyte to occur. In addition, it has recently been reported that Siglecs (Sia-binding-immunoglobulin-like lectins) are present on the sperm surface. Thus, the possibility that the recognition of oocyte Sia was sperm-Siglec-mediated was also addressed. Sperm exposed to neuraminidase (NMase) exhibited lower overall and progressive motility, which translated to a decreased ability to swim through cervical mucus from cows in oestrus...
April 4, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29615475/micrornas-crucial-regulators-of-placental-development
#10
Heyam Hayder, Jacob O'Brien, Uzma Nadeem, Chun Peng
MicroRNAs (miRNAs) are small non-coding single-stranded RNA that are integral to a wide range of cellular processes mainly through the regulation of translation and mRNA stability of their target genes. The placenta is a transient organ that exists throughout gestation in mammals, facilitating nutrient and gas exchange and waste removal between the mother and the fetus. MiRNAs are expressed in the placenta and many studies have shown that miRNAs play an important role in regulating trophoblast differentiation, migration, invasion, proliferation, apoptosis, vasculogenesis/angiogenesis, and cellular metabolism...
April 3, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29581237/female-fertility-preservation-past-present-and-future
#11
Benjamin Fisch, Ronit Abir
Anti-cancer therapy, particularly chemotherapy damages ovarian follicles and promotes ovarian failure. The only pharmacological means for protecting the ovaries from chemotherapy-induced injury is gonadotrophin-releasing hormone agonist, but its efficiency remains controversial; ovarian transposition is used to shield the ovary from radiation when indicated. Until the late 1990s, the only option for fertility preservation and restoration in women with cancer was embryo cryopreservation. The development of other assisted reproductive technologies such as mature oocyte cryopreservation and in vitro maturation of oocytes has contributed to fertility preservation...
March 26, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29559496/parthenogenesis-in-birds-a-review
#12
Reshma Ramachandran, Cd McDaniel
Parthenogenesis or "virgin birth" is embryonic development in unfertilized eggs. It is a routine means of reproduction in many invertebrates. However even though parthenogenesis occurs naturally in even more advanced vertebrates, like birds, it is mostly abortive in nature. In fact, multiple limiting factors, such as delayed and unorganized development as well as unfavorable conditions developing within the unfertilized egg upon incubation, are associated with termination of progressive development of parthenogenetic embryos...
March 20, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29540510/identification-by-proteomics-of-oviductal-sperm-interacting-proteins
#13
Julie Lamy, Perrine Nogues, Lucie Combes-Soia, Guillaume Tsikis, Valérie Labas, Pascal Mermillod, Xavier Druart, Marie Saint-Dizier
The interactions between oviductal fluid (OF) proteins and spermatozoa play major roles in sperm selection, storage and capacitation before fertilization. However, only a few sperm-interacting proteins in the OF has been identified and very little is known about the regulation of sperm-oviduct interactions across the estrous cycle. Samples of bovine frozen-thawed sperm from three bulls were incubated with OF at pre-, post-ovulatory stages (Pre/Post-ov) or luteal phase (LP) of the estrous cycle (7 mg/ml proteins, treated groups), or with a protein-free media (control)...
March 14, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29523718/potential-negative-effects-of-anti-histamines-on-male-reproductive-function
#14
Carolina Mondillo, María Luisa Varela, Adriana María Belén Abiuso, Ramiro Vázquez
Histamine (HA) is a pleiotropic biogenic amine synthesized exclusively by histidine decarboxylase (HDC) in most mammalian tissues. The literature on the role of HA within the male gonad has expanded over the last years, attracting attention to potential unexpected side-effects of anti-histamines on testicular function. In this regard, HA receptors (HRH1, HRH2 and HRH4) have been described in Leydig cells of different species, including human. Via these receptors, HA has been reported to trigger positive or negative interactions with the LH/hCG signaling pathway depending upon its concentration, thereby contributing to the local control of testicular androgen levels...
March 9, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29500186/monitoring-uterine-contractility-in-mice-with-a-transcervical-intrauterine-pressure-catheter
#15
Michael F Robuck, Christine M O'Brien, Kelsi M Knapp, Sheila Shay, James D West, J M Newton, James C Slaughter, Bibhash Paria, Jeff Reese, Jennifer L Herington
In mouse models used to study parturition or pre-clinical therapeutic testing, measurement of uterine contractions is limited to either ex vivo isometric tension or operative IUP. The goal of this study was to: 1) develop a method for transcervical insertion of a pressure catheter to measure in vivo intrauterine contractile pressure during mouse pregnancy, 2) determine whether this method can be utilized numerous times in a single mouse pregnancy without affecting the timing of delivery or fetal outcome, and 3) compare the in vivo contractile activity between mouse models of term and preterm labor (PTL)...
March 2, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29491124/effect-of-cariporide-on-ram-sperm-ph-regulation-and-motility-possible-role-of-nhe1
#16
Stefania Muzzachi, Lorenzo Guerra, Nicola Antonio Martino, Maria Favia, Giuseppe Punzi, Fabio Silvestre, Antonio Ciro Guaricci, Maria Teresa Roscino, Ciro Leonardo Pierri, Maria Elena Dell'Aquila, Valeria Casavola, Giovanni Michele Lacalandra, Elena Ciani
Sperm motility, a feature essential for in vivo fertilization, is influenced by intracellular pH (pHi ) homeostasis. Several mechanisms are involved in pHi regulation, among which sodium-hydrogen exchangers (NHEs), a family of integral transmembrane proteins that catalyse the exchange of Na+ for H+ across lipid bilayers. A preliminary characterization of NHE activity and kinetic parameters, followed by analysis of the expression and localization of the protein in ram spermatozoa was performed. NHE activity showed an apparent Km for external Na+ of 17...
February 28, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29459402/expression-and-function-of-pdcd4-in-mouse-endometrium-during-early-pregnancy
#17
Yue Zhang, Mingyun Ni, Na Liu, Yongjiang Zhou, Xuemei Chen, Yu-Bin Ding, Junlin He, Yingxiong Wang, Xueqing Liu, Yanqing Geng, Liling Xie
Embryo implantation is a complex process involving synchronised crosstalk between a receptive endometrium and functional blastocysts. Apoptosis plays an important role in this process as well as in the maintenance of pregnancy. In this study, we analysed the expression pattern of programmed cell death 4 (Pdcd4), a gene associated with apoptosis in the mouse endometrium, during early pregnancy and pseudopregnancy by real-time quantitative polymerase chain reaction, in situ hybridisation, western blotting and immunohistochemistry...
February 19, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29459401/low-dose-gonadotropin-induction-of-ovulation-in-anovulatory-women-still-needed-in-the-age-of-ivf
#18
Davinia White, Kate Hardy, Suzannah Lovelock, Stephen Franks
Low-dose, step-up gonadotropin is the treatment of choice for women with PCOS who have not conceived after anti-estrogen treatment, and as an effective alternative to pulsatile GnRH in women with hypogonadotropic hypogonadism (HH). There has been, however, no large-scale, comparative study between the two groups using low-dose gonadotropins. Here we performed a retrospective, comparative analysis, in a single clinic database, of efficacy and safety of induction of ovulation using low-dose gonadotropins in 364 Women with PCOS and 80 women with HH...
February 19, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29459400/sperm-form-and-function-what-do-we-know-about-the-role-of-sexual-selection
#19
Stefan Lüpold, Scott Pitnick
Sperm morphological variation has attracted considerable interest and generated a wealth of (mostly descriptive) studies over the past three centuries. Yet, apart from biophysical studies linking sperm morphology to swimming velocity, surprisingly little is known about the adaptive significance of sperm form and the selective processes underlying its tremendous diversification throughout the animal kingdom. Here, we first discuss the challenges of examining sperm morphology in an evolutionary context and why our understanding of it is still so poor...
February 19, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29439094/uterine-and-placental-distribution-of-selected-extracellular-matrix-ecm-components-in-the-dog
#20
Felix R Graubner, Alois Boos, Selim Aslan, Ibrahim Kücükaslan, Mariusz P Kowalewski
For many years, modifications of the uterine extracellular matrix (ECM) during gestation have not been considered as critical for successful canine (Canis lupus familiaris) pregnancy. However previous reports indicated an effect of free-floating blastocysts on the composition of the uterine ECM. Here, the expression of selected genes involved in structural functions, cell-to-cell communication and inhibition of matrix metalloproteinases were targeted utilizing qPCR and immunohistochemistry. We found that canine free-floating embryos affect gene expression of FN1, ECM1 and TIMP4...
February 9, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
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