journal
MENU ▼
Read by QxMD icon Read
search

International Immunopharmacology

journal
https://www.readbyqxmd.com/read/29335159/repeated-domperidone-treatment-modulates-pulmonary-cytokines-in-lps-induced-acute-lung-injury-in-mice
#1
Talita Rossetto Barreto, Carolina Costola-de-Souza, Rafael Oliveira Margatho, Nicolle Queiroz-Hazarbassanov, Sandra Campos Rodrigues, Luciano Freitas Felício, João Palermo-Neto, Adriano Zager
The dopaminergic antagonist drug Domperidone has immunomodulatory effects. We investigated the effects of repeated Domperidone treatment in a model of Lypopolyssacharide (LPS)-induced acute lung inflammation. Adult C57BL/6J mice were treated with either Vehicle or Domperidone for 5days, and challenged intranasally with LPS in the following day. The behavior of mice was analyzed in the open field and elevated plus-maze test before and 24h after LPS challenge. The bronchoalveolar lavage fluid, blood and lung tissue were collected 24h and 48h after LPS challenge...
January 12, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29331766/roflumilast-type-4-phosphodiesterase-inhibitor-attenuates-inflammation-in-rats-with-ulcerative-colitis-via-down-regulation-of-inos-and-elevation-of-camp
#2
Nahla E El-Ashmawy, Naglaa F Khedr, Hoda A El-Bahrawy, Samar A El-Adawy
BACKGROUND: Roflumilast (Rof), a phosphodiesterase 4 (PDE4) inhibitor, has been shown to be an effective agent in inflammatory diseases and marketed for chronic obstructive pulmonary disease. OBJECTIVE: This study was conducted to examine the potential anti-inflammatory effects of Rof in dextran sulphate sodium (DSS)-induced ulcerative colitis (UC) in rats and to investigate the molecular mechanisms underlying these effects. METHODS: Forty male Wistar rats were divided into four groups: normal control, colitis group (rats received 5% DSS in their drinking water continuously for 7 days), Rof group, and sulfasalazine (SLZ) group...
January 10, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29328946/kaempferol-alleviates-lps-induced-neuroinflammation-and-bbb-dysfunction-in-mice-via-inhibiting-hmgb1-release-and-down-regulating-tlr4-myd88-pathway
#3
Xiao Cheng, Ying-Lin Yang, Huan Yang, Yue-Hua Wang, Guan-Hua Du
Kaempferol is a natural flavonoid with many biological activities including anti-oxidation and anti-inflammation. Nevertheless, its anti-neuroinflammation role and the relevant mechanism remain unclear. The present study was to investigate effects of kaempferol against LPS-induced neuroinflammation and blood-brain barrier dysfunction as well as the mechanism in mice. BALB/c mice were treated with LPS 5mg/kg to induce inflammation after pre-treatment with kaempferol 25, 50, or 100mg/kg for 7days. The results showed that kaempferol reduced the production of various pro-inflammatory factors and inflammatory proteins including IL-1β, IL-6, TNF-α, MCP-1, COX-2 and iNOS in brain tissues...
January 9, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29328945/astaxanthin-ameliorates-cerulein-induced-acute-pancreatitis-in-mice
#4
Hui Zhang, Wenjuan Yang, Yueyue Li, Liangkai Hu, Ying Dai, Jianqing Chen, Shuqi Xu, Xuanfu Xu, Haiqiong Jiang
BACKGROUND: A various of pharmacological effects of astaxanthin has been confirmed. However, the mechanism underlying protective effect of astaxanthin on acute pancreatitis (AP) induced by cerulein still unclear. The present study is to investigate the mechanism underlying the effect of astaxanthin on autophagy and apoptosis via the JAK/STAT3 pathway. METHODS: Intraperitoneal injection of cerulein at hourly intervals followed by lipopolysaccharide injection were used in Balb/C mice...
January 9, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29324391/sirna-mediated-c-rel-knockdown-ameliorates-collagen-induced-arthritis-in-mice
#5
Tingting Fan, Fuhua Zhong, Ruiling Liu, Youhai H Chen, Ting Wang, Qingguo Ruan
Previous studies have shown that inflammatory mediators involved in the development of rheumatoid arthritis (RA) are regulated by the Rel/nuclear factor-κB (Rel/NF-κB) transcription factor family. c-Rel, a member of the Rel/NF-κB family that is preferentially expressed by immune cells, is a risk factor for several inflammatory diseases including RA. In the current study, we investigated whether targeting c-Rel can be used to treat collagen-induced arthritis, an animal model for RA. c-Rel specific siRNA (siRel) delivered by nanoparticles was used to knockdown the expression of c-Rel...
January 8, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29324390/nfat-1-hyper-activation-by-methionine-enkephalin-menk-significantly-induces-cell-apoptosis-of-rats-c6-glioma-in-vivo-and-in-vitro
#6
Wei-Cheng Lu, Hui Xie, Xin-Xin Tie, Ruizhe Wang, An-Hua Wu, Feng-Ping Shan
The aim of the work was to investigate the effect and possible mechanism of MENK on the growth of rat C6 glioma in vivo or in vitro. Our findings showed that MENK could inhibit the growth of rat C6 glioma, prolong median survival times in tumor-bearing rats, and induce glioma cell apoptosis. Moreover, MENK could increase the activities of caspase-3, caspase-8 and caspase-9. It also increased the expression of Fas, FasL, Bax, while decreased the expression of Bcl-2. We further confirmed that MENK could increase opioid receptors MOR and DOR expressions, Ca2+ influx into the cytoplasm, and a substantial increase of NFAT1accumulation in the nuclei in C6 glioma cell...
January 8, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29324356/inflammation-induced-er-stress-affects-absorptive-intestinal-epithelial-cells-function-and-integrity
#7
Sucheera Chotikatum, Hassan Y Naim, Nahed El-Najjar
Recent studies have linked impairment of intestinal epithelial function in inflammatory bowel disease to the disturbance of endoplasmic reticulum homeostasis (ER) in response to stress. Most studies are on goblet and Paneth cells, which are considered more susceptible to stress due to their role in the protection of intestinal epithelium against microbes and harmful substances. However, studies on the role of inflammation-induced ER stress in absorptive intestinal cells are scarce. In this study, we show, using Caco-2 cells as a model of intestinal epithelial barrier, that inducing ER stress using a cocktail mixture of pro-inflammatory mediators [TNFα (50ng/ml), MCP1 (50ng/ml), and IL-1β (25ng/ml)] as observed in IBD patients induces ER stress and leads to significant changes in key proteins of the apical (sucrase-isomaltase (SI), dipeptidyl-peptidase (DPPIV), and ezrin) and basolateral (E-cadherin, zonula occludens (ZO-1), and connexin-43) membranes...
January 8, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29310999/editorial-correspondence-from-chirumbolo-and-bjorklund
#8
LETTER
François Marceau
No abstract text is available yet for this article.
January 5, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29310109/soluble-tim-3-and-gal-9-are-associated-with-renal-allograft-dysfunction-in-kidney-transplant-recipients-a-cross-sectional-study
#9
Ya Mei Li, Yun Ying Shi, Yi Li, Lin Yan, Jiang Tao Tang, Yang Juan Bai, Xiao Juan Wu, Bo Dai, Yuan Gao Zou, Lan Lan Wang
BACKGROUND: T cell immunoglobulin mucin-3 (Tim-3) has been reported to participate in the regulation of immune response and the induction of allograft tolerance. However, the association between Tim-3 and renal allograft dysfunction is unclear. We studied the expression of cellular and soluble Tim-3 (sTim-3), soluble galectin-9 (sGal-9) and carcinoembryonic antigen-related cell adhesion molecule-1 (sCEACAM-1) in kidney transplantation recipients (KTRs) to explore their roles in allograft dysfunction...
January 5, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29310108/effects-of-guluronic-acid-g2013-on-ship1-socs1-induction-and-related-molecules-in-tlr4-signaling-pathway
#10
Seyed Shahabeddin Mortazavi-Jahromi, Ali Farazmand, Nasrin Motamed, Shadi Sadat Navabi, Abbas Mirshafiey
OBJECTIVE: This research aimed to study the anti-inflammatory and immunomodulatory effects of guluronic acid (G2013) on gene expression of TLR4, MyD88, SHIP1, SOCS1, NF-κB, and assessment of the level of IL-1β as a pro-inflammatory cytokine in HEK-Blue hTLR4 cell line. METHODS: The cytotoxicity of G2013 was assessed by the MTT assay. The mRNA expression levels of the mentioned genes were measured by qRT-PCR. IL-1β concentration in culture media was determined using ELISA method...
January 5, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29310107/zerumbone-suppresses-the-activation-of-inflammatory-mediators-in-lps-stimulated-u937-macrophages-through-myd88-dependent-nf-%C3%AE%C2%BAb-mapk-pi3k-akt-signaling-pathways
#11
Md Areeful Haque, Ibrahim Jantan, Hemavathy Harikrishnan
Zerumbone (ZER), isolated mainly from the Zingiber zerumbet (Z. zerumbet) rhizomes was found to be effective against numerous inflammatory and immune disorders, however, the molecular and biochemical mechanisms underlying its anti-inflammatory and immunosuppressive properties have not been well studied. This study was carried out to examine the profound effects of ZER on inflammatory mediated MyD88-dependent NF-κB/MAPK/PI3K-Akt signaling pathways in LPS-stimulated U937 human macrophages. ZER significantly suppressed the up-regulation pro-inflammatory mediators, TNF-α, IL-1β, PGE2, and COX-2 protein in LPS-induced human macrophages...
January 5, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29310106/vaccination-with-fasl-tcl-plus-mhsp65-induces-improved-anti-lung-cancer-immunity-in-mice
#12
Bohan Dong, Guangli Dai, Yuanyuan Ding, Beiru Wang, Siyuan Zhang
In a previous study, we constructed a MHSP65-TCL anti-lung cancer vaccine with Lewis lung carcinoma TCL plus MHSP65, and illustrated its anti-lung cancer effect through specific and nonspecific anti-tumor immunity. However, TCL contains some immunoinhibit components such as FasL. If this component can be eliminated from TCL, the anti-tumor immunity of MHSP65-TCL constructed with TCL should be improved. In the present study, we knocked down FasL from Lewis lung carcinoma cells and prepared MHSP65-(FasL-/TCL) with this cell line's TCL...
January 5, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29306173/blocking-osteopontin-fibronectin-interactions-reduce-extracellular-fibronectin-deployment-and-arthritic-immunopathology
#13
Brij Bhushan Mehta, Saniya Sharma, Rakesh K Vasishta, Ramesh K Sen, Aman Sharma, Manni Luthra-Guptasarma
Elevated levels of a thrombin-cleaved fragment of osteopontin (OPNT) are seen in synovial fluid (SF) and tissues of rheumatoid arthritis (RA) patients. OPNT binds to integrins on cell surfaces, inducing adhesion, migration and survival of inflammatory cells in the synovial joints, where OPNT binds to fibronectin to link fibroblast-like synoviocytes (FLS) with B cells, stimulating the latter to produce inflammatory cytokines. Our aim was to block OPNT-fibronectin interactions and examine whether this reduces inflammation...
January 3, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29294439/plumbagin-suppresses-the-human-large-cell-lung-cancer-cell-lines-by-inhibiting-il-6-stat3-signaling-in-vitro
#14
Tao Yu, Yan-Yan Xu, Ying-Ying Zhang, Kai-Yu Li, Yi Shao, Gang Liu
BACKGROUND: Large cell lung cancer (LCLC) patients have a poor prognosis because their tumors are highly malignant and show resistance to chemotherapy and radiotherapy. Plumbagin has anticancer activity toward several tumor types, but its effects on LCLC are unknown. This study investigated the effects of plumbagin on human L9981 and NL9980 large cell lung cancer cells and the mechanisms underlying its action. METHODS: The effects of plumbagin on L9981 and NL9980 cells proliferative activity and invasion were analyzed using MTT and Boyden chamber assays, respectively...
December 30, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29291543/platelet-rich-plasma-inhibits-wnt-%C3%AE-catenin-signaling-in-rabbit-cartilage-cells-activated-by-il-1%C3%AE
#15
Jian Wu, Ji-Feng Huang, Xing-Xing Qin, Feng Hu, Zhao-Fei Chen, Yong Zheng, Yan-Xi Liu, Xian-Hua Cai
OBJECTIVE: Platelet-rich plasma (PRP) has been reported to alleviate degenerative pathological damage to joint cartilage. This study aimed to investigate the effect of PRP on Wnt/β-catenin signaling in rabbit chondrocytes. METHODS: Using 3-month-old New Zealand white rabbits, PRP was prepared from venous blood, and chondrocytes were cultured from knee joint cartilage and identified by staining for type II collagen and proteoglycan. The effects of PRP on chondrocyte viability were measured...
December 29, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29291542/protocatechuic-acid-inhibits-toll-like-receptor-4-dependent-activation-of-nf-%C3%AE%C2%BAb-by-suppressing-activation-of-the-akt-mtor-jnk-and-p38-mapk
#16
Yoon Jeong Nam, Chung Soo Lee
Protocatechuic acid has demonstrated to have antioxidant and anti-inflammatory effects. We assessed whether protocatechuic acid may reduce the inflammatory mediator production, which is regulated by the Toll-like receptor-4-dependent Akt, mTOR and NF-κB pathway, and JNK and p38-MAPK in HaCaT cells and primary keratinocytes. Protocatechuic acid, Akt inhibitor, Bay 11-7085 and N-acetylcysteine reduced the lipopolysaccharide-caused production of cytokines and chemokines, expression of cyclooxygenase, increase in the levels and activities of Toll-like receptor-4, p-Akt and mTOR, activation of NF-κB, phosphorylation of the JNK and p38-MAPK, and production of reactive oxygen species in keratinocytes...
December 29, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29288926/efhd2-swiprosin-1-regulates-lps-induced-macrophage-recruitment-via-enhancing-actin-polymerization-and-cell-migration
#17
Ye Tu, Lichao Zhang, Lingchang Tong, Yue Wang, Su Zhang, Rongmei Wang, Ling Li, Zhibin Wang
Macrophage motility is vital in innate immunity, which contributes strategically to the defensive inflammation process. During bacterial infection, lipopolysaccharide (LPS) potently activates the migration of macrophages via the NF-κB/iNOS/c-Src signaling pathway. However, the downstream region of c-Src that participates in macrophage migration is unclear. EFhd2, a novel actin bundling protein, was evaluated for its role in LPS-stimulated macrophage migration in this study. We found that LPS stimulated the up-regulation, tyrosine phosphorylation and membrane translocation of EFhd2 in macrophages...
December 27, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29288925/effects-of-human-adipose-derived-mesenchymal-stem-cells-combined-with-estrogen-on-regulatory-t-cells-in-patients-with-premature-ovarian-insufficiency
#18
Kaijing Song, Huihua Cai, Dongmei Zhang, Ruichun Huang, Donghua Sun, Yuanli He
OBJECTIVE: To investigate the effects of human adipose-derived mesenchymal stem cells (hADSCs) combined with estrogen on regulatory T cells (Tregs) in patients with premature ovarian insufficiency (POI). METHODS: hADSCs were isolated by enzymatic digestion and identified by flow cytometry. Peripheral blood mononuclear cells (PBMCs) were isolated from POI patients and healthy controls. PBMCs were cultured in the following experimental groups: the control group, hADSC group, estrogen group and combined group...
December 27, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29287251/quercetin-in-the-experimental-liver-fibrosis-induced-by-carbon-tetrachloride-ccl4
#19
LETTER
Salvatore Chirumbolo, Geir Bjørklund
No abstract text is available yet for this article.
December 26, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29274626/the-dual-regulatory-function-of-lienal-peptide-on-immune-system
#20
Jing Wang, Mengzhu Zheng, Qiuxia Min, Ya Gao, Weiguang Sun
Lienal peptide (LP), extracted from the spleen of healthy calves, has been reported to be a unique immune modulator which shows notable immunomodulatory effects on immune system function. This study was designed to further investigate the immunomodulatory effect of LP in vitro and in vivo. The results showed that LP significantly decreased the LPS-induced overexpression levels of pro-inflammatory cytokines including IL-1β, IL-15, TNF-α and MIP-1α, through the NF-κB pathway. Moreover, LP showed an immunologic enhancement effect on immunosuppressed mice which were induced by cytarabine...
December 20, 2017: International Immunopharmacology
journal
journal
35181
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"