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International Immunopharmacology

Yang Yu, Yongyan Yang, Man Yang, Chunyan Wang, Keliang Xie, Yonghao Yu
BACKGROUND: Lung injury is a vital contributor of mortality in septic patients. Our previous studies have found that molecular hydrogen (H2 ), which has anti-oxidant, anti-inflammatory, and anti-apoptosis effects, had a therapeutic effect on a septic animal model through increasing expression of nuclear factor-erythroid 2-related factor 2 (Nrf2). The aim of this research was to investigate the effects of 2% H2 gas inhalation on sepsis-induced lung injury and its underlying mechanisms...
January 17, 2019: International Immunopharmacology
Baihui Ma, Yinfan Wu, Binlin Chen, Yanling Yao, Yanyan Wang, Haolei Bai, Chunwei Li, Yan Yang, Yanqiu Chen
Cyanidin-3-O-β-glucoside (Cy-3-g), a typical and abundant monomer of anthocyanins, exhibits a variety of biological activities, such as anti-atherosclerosis, anti-obesity, and anticancer effects. However, to date little is known about its effects on asthma. This study aimed to investigate the efficacy of dietary Cy-3-g on allergic asthma in an animal model. BALB/c mice were sensitized and challenged with ovalbumin (OVA) to induce allergic asthma. The pathological changes of the lung tissues, type 2 helper (Th2)-associated cytokine production in bronchoalveolar lavage fluid (BALF), and the interleukin 4 receptor alpha (IL-4Rα)-signal transducer and activator of transcription 6 (STAT6) signaling pathway activities were assessed...
January 17, 2019: International Immunopharmacology
Wenpeng Hui, Dapeng Yu, Zhong Cao, Xiwu Zhao
Rheumatoid arthritis (RA) is a chronic autoimmune disorder demanding the development of novel therapeutic strategy. Butyrate is a functional short-chain fatty acid produced by the anaerobic intestinal microbiota. This study aimed to investigate the attenuation of butyrate on RA. The collagen-induced arthritis (CIA) mouse model was established and butyrate was administered in drinking water along with the collagen immunization. The histopathological features, clinical score, paw swelling, as well as the production of pro-inflammatory cytokines including interleukin (IL)-1β, IL-6 and IL-17A were measured to determine the amelioration of butyrate on arthritis...
January 15, 2019: International Immunopharmacology
Jing-Jing Wu, Xiao-Mei Yuan, Chao Huang, Guo-Yin An, Zhan-Ling Liao, Guang-An Liu, Run-Xiang Chen
Inducible nitric oxide synthase (iNOS) is a molecule critical for the development of inflammation-associated disorders. Its induction should be tightly controlled in order to maintain cellular homeostasis. Upon lipopolysaccharide (LPS) stimulation, iNOS, in most settings, is induced by the activation of inhibitor of κB-α (IκB-α)-nuclear factor κB (NF-κB) signaling. Farnesyl thiosalicylic acid (FTS), a synthetic small molecule that is considered to detach Ras from the inner cell membrane, has been shown to exhibit numerous anti-inflammatory functions...
January 15, 2019: International Immunopharmacology
Rie Tabata, Chiharu Tabata, Hiroko Uesugi, Yusuke Takei
Patients with rheumatoid arthritis occasionally develop lymphoproliferative disorders. Methotrexate-associated lymphoproliferative disorders is a lymphoproliferative disease or lymphoma in patients treated with methotrexate for autoimmune diseases, such as rheumatoid arthritis. Here we report two rare cases of highly aggressive plasmablastic lymphoproliferative disorders in rheumatoid arthritis treated with methotrexate. Case 1 is a 68-year-old female patient with leukemic transformation of malignant lymphoma...
January 15, 2019: International Immunopharmacology
Hui Wu, Heng Fan, Zhexing Shou, Meng Xu, Qianyun Chen, Changzheng Ai, Yalan Dong, Yujin Liu, Zhen Nan, Yifan Wang, Ting Yu, Xingxing Liu
Accumulating evidence indicates that microRNA-146a (miR-146a), a well-known anti-inflammatory miRNA, acts as a negative feedback regulator of the innate immune response, but its role in modulation of inflammatory bowel disease (IBD) remains unclear and the issue related to the stability of exogenous miR-146a in blood is up in the air. In this study, extracellular vesicles (EVs) from cultured medium of bone-marrow mesenchymal stem cells (BMSCs) transfected with recombinant lentiviruses can serve as a stable delivery system and overexpress miR-146a, which significantly inhibited TNF receptor-associated factor 6 (TRAF6) and IL-1 receptor-associated kinase 1 (IRAK1) expression in TNBS-induced colitis of rats...
January 14, 2019: International Immunopharmacology
Jin Geng, Ye Yuan, Xue Jiao, Ruizhe Wang, Ning Liu, Hao Chen, Noreen Griffin, Fengping Shan
The purpose of this study was to identify the modulatory effect of MENK on MDSCs and to investigate the relationship between this modulation and the expression of opioid receptors. Our results showed that MENK could inhibit the proliferation of MDSCs from both marine bone marrow and spleen. MENK also could promote the expression of opioid receptors MOR and DOR. MENK suppressed the PMN-MDSCs generated from splenocyte while up-regulated M-MDSCs. The stimulation of MENK increased the production of IL-4 secreted by MDSCs from slpenocytes...
January 14, 2019: International Immunopharmacology
Hongyan Qian, Mian Wang, Ying Wang, Wangqian Ying, Junhui Zhang, Yu Huan, Yan He, Yuan Liu, Guixiu Shi
Psoriasis (PSO) is a chronic inflammatory skin disease characterized with skin lesions and abnormal keratinocyte proliferation. The immune dysregulation is involved in the pathogenesis of PSO. However, the detail of immune regulation in PSO is still not very clear. Gαq, the alpha subunit of the Gq protein, played important role in the immune regulation. In this study, we aimed to investigate whether Gαq was involved in the pathogenesis of PSO. We detected the Gαq expression level and analyzed its relationship with test parameters of PSO patients...
January 14, 2019: International Immunopharmacology
Panpan Zhang, Yuhua Chen, Huafei Zhao, Hao Du
Osteoarthritis (OA) is a common debilitating disease most prevalent among the elderly population worldwide. Excessive degradation of the articular extracellular matrix is a pivotal event in the development of OA. Preventative treatments against the destruction of type II collagen and aggrecan, the two main components of the articular extracellular matrix, may serve as a novel therapy against the progression of OA. In the current study, we investigated whether the DPP-4 inhibitor alogliptin could prevent degradation of the articular extracellular matrix in human primary chondrocytes...
January 14, 2019: International Immunopharmacology
Yutong He, Zijing Xia, Deqing Yu, Jiankang Wang, Liang Jin, Demin Huang, Xiaoli Ye, Xuegang Li, Baoshun Zhang
Acute liver failure (ALF) is a distinct clinical syndrome with high mortality and characterized by metabolic derangements, neurological complication, and multiple failures. Flavonoids exert great biological properties on anti-oxidation, anti-inflammation, and anti-apoptosis. After lipopolysaccharide (LPS)/d-galactosamine (d-GalN) administration, five flavonoids inhibited oxidative activities with reducing nitric oxide synthase (iNOS), malondialdehyde (MDA), and improving catalase (CAT), superoxide dismutase (SOD), total antioxidant capacity (T-AOC), nuclear factor erythroid-derived 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1)...
January 11, 2019: International Immunopharmacology
Hamid Yaghooti, Narges Mohammadtaghvaei, Khadijeh Mahboobnia
Mesenchymal stem cells (MSCs) have broad immunomodulatory activities. These cells are a stable source of cytokine production such as interleukin-6 (IL6), monocyte chemoattractant protein-1 (MCP-1/CCL2) and vascular endothelial growth factor (VEGF). Fatty acid elevation in chronic metabolic diseases alters the microenvironment of MSCs and thereby, might affect their survival and cytokine production. In the present study, we investigated the effects of palmitate, the most abundant saturated free fatty acid (FFA) in plasma, and astaxanthin, a potent antioxidant, on cell viability and apoptosis in human bone marrow-driven mesenchymal stem cells...
January 9, 2019: International Immunopharmacology
Fukushi Abekura, Junyoung Park, Choong-Hwan Kwak, Sun-Hyung Ha, Seung-Hak Cho, Young-Chae Chang, Ki-Tae Ha, Hyeun-Wook Chang, Young-Choon Lee, Tae-Wook Chung, Cheorl-Ho Kim
Natural compound esculentoside B (EsB), (2S,4aR,6aR,6aS,6bR,8aR,9R,10R,11S,12aR,14bS)-11-hydroxy-9-(hydroxymethyl)-2 methoxycarbonyl-2,6a,6b,9,12a-pentamethyl-10-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxy-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid with molecular weight of 664.833, isolated from roots of Phytolacca acinosa Roxb has been widely used as a constituent of traditional Chinese medicine (TCM). However, the anti-inflammatory capacity of EsB has not been reported yet...
January 9, 2019: International Immunopharmacology
Shuyao Hua, Mingyang Ma, Xiaoyuan Fei, Yuanyue Zhang, Feili Gong, Min Fang
Gasdermin D (GSDMD), a genetic substrate for inflammatory caspases, plays a central role in pyroptosis of macrophages and release of interleukin‑1β (IL-1β), but was mainly referred to microbial infection. High mobility group box-1 (HMGB1), served as an alarm molecule during various pathological process, has been widely recognized to be involved in liver ischemia-reperfusion (I/R). Glycyrrhizin, a natural anti-inflammatory and antiviral triterpene in clinical use, was recently referred to have ability to prevent I/R induced liver injury by inhibiting HMGB1 expression and activity...
January 8, 2019: International Immunopharmacology
Shan Cong, Longquan Xiang, Xiutai Yuan, Dong Bai, Xuehua Zhang
BACKGROUND: Pneumonia is a common lung disease in children with high fatality rate. Notoginsenoside R1 (NGR1) is the main active component extracted from the roots of Panax notoginseng (Burk.) F.H. Chen (Araliaceae). Here, we carefully explored the potential anti-inflammatory and protective effects of NGR1 on lipopolysaccharide (LPS)-induced lung fibroblast MRC-5 cell injury. METHODS: Viability and apoptosis of MRC-5 cells after different treatment or transfection were respectively assessed using CCK-8 assay and Annexin V-FITC/PI staining...
January 7, 2019: International Immunopharmacology
Bo Zhang, You Lang Zhou, Xinming Chen, Ziheng Wang, Qiuhong Wang, Fei Ju, Shiqi Ren, Ran Xu, Qun Xue, Qiong Wu
BACKGROUND: Although immune checkpoint inhibitor monotherapy has demonstrated significant efficacy in advanced melanoma, no study has systematically evaluated the efficacy and safety of the combination regimens. In this study, we conduct a comprehensive meta-analysis to explore the efficacy and safety of CTLA-4 inhibitors combined with PD-1 inhibitors or chemotherapy in advanced melanoma. METHODS: We performed a systematic search of Medline, PubMed, Embase and Web of Science for relevant clinical trials...
January 7, 2019: International Immunopharmacology
Man Li, Jia Yu, Liang Zhao, Fang-Chao Mei, Yu Zhou, Yu-Pu Hong, Teng Zuo, Wei-Xing Wang
Acute pancreatitis in pregnancy (APIP) is a severe disease during pregnancy that mostly occurs during the third trimester. It can lead to additional complications including preterm delivery and high fetal mortality. In this study, we investigated the protective effects of (S, R)-3-(4-hydroxyphenyl)-4, 5dihydro-5-isoxazole acetic methyl ester (ISO-1), an inhibitor of macrophage migration inhibitory factor (MIF), on fetal kidney injury associated with the maternal acute necrotizing pancreatitis (ANP) and its potential mechanisms in a rat model...
January 7, 2019: International Immunopharmacology
Na-Rae Shin, Hyung-Jun Kwon, Je-Won Ko, Joong-Sun Kim, In-Chul Lee, Jong-Choon Kim, Sung-Hwan Kim, In-Sik Shin
S-Allyl cysteine (SAC) is an active component in garlic and has various pharmacological effects, such as anti-inflammatory, anti-oxidant, and anti-cancer activities. In this study, we explored the suppressive effects of SAC on allergic airway inflammation induced in an ovalbumin (OVA)-induced asthma mouse model. To induce asthma, BALB/c mice were sensitized to OVA on days 0 and 14 by intraperitoneal injection and exposed to OVA from days 21 to 23 using a nebulizer. SAC was administered to mice by oral gavage at a dose of 10 or 20 mg/kg from days 18 to 23...
January 6, 2019: International Immunopharmacology
Tássia B Pessato, Natália C de Carvalho, Daniella de Figueiredo, Talita C Colomeu, Luís Gustavo R Fernandes, Flavia M Netto, Ricardo de L Zollner
Proteins and phenolic compounds can interact and form soluble and insoluble complexes. In this study, the complexation of whey protein isolate (WPI) with caffeic acid (CA) or (-)‑epigallocatechin‑3‑gallate (EGCG) is investigated as a strategy to attenuate oral sensitization in C3H/HeJ mice against WPI. Treatment with WPI-CA reduced the levels of IgE, IgG1, IgG2a and mMCP-1 in serum of mice measured by ELISA. This might be related to CD4+ LAP+ Foxp3+ T and IL-17A+ CD4+ T (Th17) cell activation, evidenced by flow cytometry of splenocytes...
January 5, 2019: International Immunopharmacology
Lumei Liu, Zhengxiao Zhao, Linwei Lu, Jiaqi Liu, Jing Sun, Xiao Wu, Jingcheng Dong
Inflammation is a defensive response of the body and is at the center of many diseases' process like depression. High mobility group protein box 1 (HMGB1), has been proved to function as a pro-inflammatory cytokine. We aim to explore the role of HMGB1 played in the neuroinflammation here. In this study, we used LPS to induce an acute inflammatory response, and to measure the anti-neuroinflammation effect of icariin (ICA) and icaritin (ICT). We found that LPS could increase the expression of HMGB1 in serum and hippocampus, along with a high expression of HMGB1 in the cytoplasm and a high expression of RAGE, which could be rescued by ICA and ICT, and ethyl pyruvate (EP) pretreatment showed similar effects here...
January 4, 2019: International Immunopharmacology
Yue Huang, Lei Wang, Xiao-Xiao Jia, Xi-Xi Lin, Wei-Xi Zhang
Vitamin D exerts a protective role in asthma; however, the molecular mechanisms underlying the vitamin D-attenuated asthma airway remodeling are yet to be elucidated. In this study, Sprague-Dawley (SD) rats were randomly divided into four groups: control, asthma, vitamin D 50 ng/mL, and vitamin D 100 ng/mL. The treatment with 100 ng/mL vitamin D remarkably reduced the thickness of the airway smooth muscle, collagen deposition, and the alpha-smooth muscle actin (α-SMA) mass and airway inflammation. Conversely, the treatment by vitamin D significantly up-regulated the serum levels of 25(OH)2 D3 that were decreased in asthma...
January 4, 2019: International Immunopharmacology
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