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International Immunopharmacology

Quanfang Huang, Xiaolin Zhang, Facheng Bai, Jinlan Nie, Shujuan Wen, Yuanyuan Wei, Jinbin Wei, Renbin Huang, Min He, Zhongpeng Lu, Xing Lin
Methyl helicterate (MH) has been reported to have protective effects against CCl4 -induced hepatic injury and fibrosis in rats, but its protective mechanism, especially on hepatic stallete cells (HSCs), remains unclear. Recently, our pilot experiment showed that MH could inhibit miR-21 expression in HSC-T6 cells, suggesting that miR-21 may be one of the targets of MH to intervene liver fibrosis. To verify the hypothesis, the present study would focus on the regulatory effect of MH on the miR-21-mediated ERK and TGF-β1/Smads pathways...
November 9, 2018: International Immunopharmacology
Jingyun Xu, Mingxu Liu, Pengcheng Yu, Lijia Wu, Yixin Lu
Inflammatory bowel disease (IBD) is a chronic autoimmune disease with a high recurrence rate. Ulcerative colitis (UC) and Crohn's disease (CD) are two types of IBD. At present, parasite-derived cysteine protease inhibitors have received extensive attention from researchers, and experiments have confirmed that these protease have an effect on certain autoimmune diseases. So we conducted experiments to investigate the effect of Trichinella spiralis cysteine protease inhibitors on TNBS-induced mouse CD models...
November 9, 2018: International Immunopharmacology
Ying-Li Zhu, Meng-Fei Sun, Xue-Bing Jia, Kun Cheng, Yi-Da Xu, Zhi-Lan Zhou, Pei-Hao Zhang, Chen-Meng Qiao, Chun Cui, Xue Chen, Xu-Sheng Yang, Yan-Qin Shen
Astilbin (AST), a dihydro-flavonol glycoside, is a major bioactive ingredient in Astilbe thunbergii, Engelhardia roxburghiana, Smilax corbularia and Erythroxylum gonocladum, and has been shown to have anti-inflammatory, antioxidative and neuroprotective effects, suggesting potential therapeutic value in the treatment of Parkinson's disease (PD). We explored the neuroprotective effects of AST in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease mice. Mice were administered with MPTP (30 mg/kg, i...
November 9, 2018: International Immunopharmacology
Di Liu, Jing You, Yexin Liu, Xiaofang Tang, Xia Tan, Ming Xia, Lingzhi Wu, Guochun Chen, Liyu He, Xuejing Zhu, Hong Liu
BACKGROUND: Immunoglobulin A (IgA) nephropathy (IgAN) is a common primary glomerular disease that potentially leads to renal failure, risk prediction of declining kidney function is crucial for early clinical management. Immunoglobulin G (IgG) is an important constituent of the immune system and serves as the preferred therapeutic target in human autoimmune diseases. However, its role in the progression of IgAN is unclear. METHODS: From May 2009 to April 2014, 455 patients diagnosed with IgAN at the Second Xiangya Hospital were enrolled in this study; the median follow-up was 42...
November 8, 2018: International Immunopharmacology
Wei Wang, Shanhu Mao, Hongli Yu, Hao Wu, Xuelian Shan, Xingde Zhang, Guojing Cui, Xianqiong Liu
Pinellia pedatisecta, a widely used herb in Chinese medicine, has proinflammatory toxicity related to its Pinellia pedatisecta lectin (PPL), but the mechanism is still unknown. However, for safer use, it is necessary to clarify its proinflammatory mechanism. Herein, we studied the mechanism in RAW264.7 cells. PPL decreased the mitochondrial membrane potential (MMP) and increased the outflow of calcium, accompanied by the overproduction of reactive oxygen species (ROS), which resulted in the activation of the MAPK and NF-κB pathways and the release of IL-1β...
November 8, 2018: International Immunopharmacology
Chongyang Wang, Yun Ho Choi, Zhemin Xian, Mingyu Zheng, Hongmei Piao, Guanghai Yan
To explore the effects of aloperine (ALO) on allergic airway inflammation, we investigated whether its mechanism is related with NF-κB, MAPK, and Nrf2/HO-1 signaling pathways. Histochemical staining and inflammatory cell count were used to observe lung histopathological changes in mice. ELISA was used to detect the content of inflammatory cytokines and IgE in the mouse bronchoalveolar lavage fluid (BALF). Airway hyperresponsiveness (AHR) to inhale methacholine was measured by the plethysmography in conscious mice...
November 8, 2018: International Immunopharmacology
Yan Du, Lan-Lan Li, Hao Chen, Cong Wang, Xue-Wen Qian, Yu-Bin Feng, Lei Zhang, Fei-Hu Chen
Myelodysplastic syndromes (MDS) are a varied set of hematologic neoplasms and a high risk of progression to acute myeloid leukemia (AML). 4-Amino-2-trifluoromethyl-phenyl retinate (ATPR), a novel all-trans retinoic acid (ATRA) derivative, play an important role in various types of cancer cells as a tumor inhibitor. However, little is known concerning its antitumor effect on MDS. The cell viability and the percentage of apoptotic cells were used to measure MTT, Flow Cytometry and Hoechst 33342/PI staining. In addition, real-time quantitative RT-PCR (qRT-PCR) and western blotting were used to analyzed the expression of p53, as well as the levels of BNIP3, apoptosis proteins of Caspase-3, BAX and BCL-2...
November 8, 2018: International Immunopharmacology
Tianlong Pan, Rong Chen, Dengying Wu, Ningyu Cai, Xuchao Shi, Bin Li, Jun Pan
No abstract text is available yet for this article.
November 6, 2018: International Immunopharmacology
Yingzhen Wang, Jianqiang Kou, Haining Zhang, Changyao Wang, Haiyan Li, Yuanzhong Ren, Yongtao Zhang
Periarticular osteopenia is the most specific hallmark of rheumatoid arthritis (RA). The renin-angiotensin system (RAS) in the synovium has been found to participate in the pathogenic process of RA. This study examined whether and how RAS regulates periarticular osteopenia in RA. The synovial tissues from patients with RA and osteoarthritis (OA) were prepared. Female Sprague-Dawley rats were treated with either saline, bovine type II collagen (CII) to induce arthritis (CIA), or CII combined with perindopril, an inhibitor of angiotensin-converting enzyme (ACE)...
November 6, 2018: International Immunopharmacology
Weijing Fang, Xiaopeng Zhou, Jingkai Wang, Langhai Xu, Lijuan Zhou, Wei Yu, Yiqing Tao, Jian Zhu, Bin Hu, Chengzhen Liang, Fangcai Li, Jianming Hua, Qixin Chen
Intervertebral disc degeneration (IVDD) is a prevalent disease characterized by the progressive loss of the extracellular matrix in the local nucleus pulposus region. Metalloproteinases and pro-inflammatory cytokines play an important role in this process. Thus, anti-inflammatory strategies are an important component of IVDD treatment. Wogonin, a naturally existing monoflavonoid, has been reported to have potential anti-inflammatory effects in some inflammatory diseases. Hence, in our present study we investigated the protective effects and potential mechanisms of wogonin in rat nucleus pulposus cells that had been treated with interleukin-1beta (IL-1β) to induce severe IVDD...
November 6, 2018: International Immunopharmacology
Yifei Liu, Zhengyi Li, Xiaoxu Xue, Yong Wang, Yijie Zhang, Junpeng Wang
Paraquat (PQ) induces acute lung injury (ALI) and immunotoxicity. Apigenin exerts anti-oxidant and anti-inflammatory properties. The purpose of this study was to investigate the possible protective effects of apigenin on PQ-induced ALI and immunotoxicity in mice. Female C57BL/6 mice received a single injection of PQ (50 mg/kg). Apigenin was given for 7 consecutive days starting 5 days before PQ exposure. The toxicity markers were evaluated in terms of weight loss, lung histopathology, oxidative stress, inflammation, and T cell functions after PQ exposure...
November 5, 2018: International Immunopharmacology
Xu Chen Lin, Xin Liu, Kai Li, Chang Zhao, Song Xu, Yue Zhang, Xiao Chun Bai, Dao Zhang Cai
This study aims to investigate the effect of enriched plasma cells on the production of inflammatory cytokines and development of osteoarthritis (OA) in mice with B-cell-specific conditional deletion of the tuberous sclerosis 1 gene (TSC1). OA was induced by destabilization of the medial meniscus (DMM) in mice with TSC1 disruption in B cells (CD19-TSC1) and in littermate control mice (CON). The effects of DMM and incidence of OA were evaluated histologically, mRNA levels of inflammatory cytokines were detected by polymerase chain reaction, and serum cytokine levels were detected by enzyme-linked immunosorbent assay...
November 5, 2018: International Immunopharmacology
Zhiyuan Sun, Tao Wei, Xiaoying Zhou
Rheumatoid arthritis (RA) is an autoimmune disease and characterized by the excessive cell proliferation, abnormal cell cycle of lymphocytes and synovial cells. The therapeutic effects of curcumin in active RA patients were reported, but limited by its insolubility and rapid systemic elimination. Dimethyl curcumin (DiMC) is a metabolically stable analogue of curcum with anti-inflammatory property. In this study, liposomes encapsulated dimethyl curcumin (Lipo-DiMC) was prepared to improve the bioavailability and metabolic-stability; collagen induced arthritis (CIA) rat model was employed to investigate the effects of Lipo-DiMC treatments during CIA progress...
November 5, 2018: International Immunopharmacology
Yiting Geng, Danxia Zhu, Chen Wu, Jun Wu, Qi Wang, Ruiqi Li, Jingting Jiang, Changping Wu
BACKGROUND: Inflammation is closely associated with the initiation and development of tumors. Based on the counts of peripheral neutrophils, monocytes and lymphocytes, we established a new systemic inflammation response index (SIRI) to predict postoperative survival of patients with esophageal squamous cell carcinoma (ESCC). METHODS: A total of 916 ESCC patients treated with radical esophagectomy were enrolled in the present study. RESULTS: Survival analysis indicated that the median overall survival (OS) in patients with SIRI≤1...
November 5, 2018: International Immunopharmacology
Amany Balah, Omnia Ezzat, El-Sayed Akool
Cyclosporin A (CsA) is the most common immunosuppressive drug used in organ transplantation. However, the clinical use of CsA is often limited by several side effects including hepatotoxicity. In the present study, it was found that administration of CsA causes a rapid activation of TGF-β/Smad signaling cascade and subsequent expression of the profibrotic genes connective tissue growth factor (CTGF) and tissue inhibitors of matrix metallproteinases-1 (TIMP-1) in rat liver. In addition, Smad phosphorylation and subsequent CTGF and TIMP-1 expression were markedly reduced in the presence of neutralizing monoclonal TGFβ1-3 antibody...
November 1, 2018: International Immunopharmacology
Francisco Herrera-Gómez, Waldo Del Aguila, Armando Tejero-Pedregosa, Marcel Adler, Rosario Padilla-Berdugo, Álvaro Maurtua-Briseño-Meiggs, Julio Pascual, Manuel Pascual, David San Segundo, Sebastiaan Heidt, F Javier Álvarez, Carlos Ochoa-Sangrador, Claude Lambert
BACKGROUND: The kinetics of the FoxP3 regulatory T-cell (Treg) population in kidney transplant recipients (KTR) are related to the clinical effect of immunosuppression based on mammalian Target Of Rapamycin inhibitors (mTORi) with/without belatacept (predictive biomarker). METHODS: A multistage systematic review of published and unpublished literature is presented [registration IDs in the International Prospective Register of Systematic Reviews (PROSPERO): CRD42017057570, CRD42018085019, CRD42018084941, CRD42018085186]...
October 31, 2018: International Immunopharmacology
Yifan Peng, Yufu Ye, Junjun Jia, Yong He, Zhentao Yang, Xiaolu Zhu, Hechen Huang, Wei Wang, Lei Geng, Shengyong Yin, Lin Zhou, Shusen Zheng
Donor-derived tolerogenic dendritic cells (DCs) and apoptotic lymphocytes (ALs) are practical tools for controlling rejection after transplantation by targeting direct and indirect allorecognition pathways, respectively. To date, few studies have investigated the combination of donor-derived tolerogenic DCs and ALs infusion in organ transplantation protection. In the present study, we generated galectin-1-induced tolerogenic DCs (DCgal-1 s) and ultraviolet irradiation-induced ALs with stable immune characteristics in vitro and potential immune regulatory activity in vivo...
October 31, 2018: International Immunopharmacology
Xuerong Zhao, Lianhong Yin, Lingling Fang, Lina Xu, Pengyuan Sun, Ming Xu, Kexin Liu, Jinyong Peng
Development of active compounds to control inflammation against systemic inflammatory response syndrome (SIRS) is critical important. Dioscin shows anti-inflammatory effects in our previous works. However, the action of the compound on SIRS still remained unknown. In the present paper, zymosan induced generalized inflammation (ZIGI) models in mice and rats, and PMA-differentiated THP‑1 cells stimulated by lipopolysaccharide (LPS) and Pam3-Cys-Ser-Lys4 (Pam3CSK4) were used. The results showed that dioscin significantly inhibited the proliferation of THP‑1 cells stimulated by LPS and Pam3CSK4, obviously reduced the soakage of inflammatory cells and necrosis in liver, kidney and intestine of rats and mice, and reduced peritoneal ascites fluid compared with ZIGI model groups...
October 31, 2018: International Immunopharmacology
Xiaofei Peng, Tao Yang, Guoyong Liu, Hong Liu, Youming Peng, Liyu He
BACKGROUND: Lupus nephritis (LN) is a leading cause of mortality. The activation of NLRP3 inflammasome contributed to LN development and thus became a therapeutic target. Here we assessed the therapeutic potential of piperine, a bioactive compound known to target NLRP3 inflammasome, on LN development both in vivo and in vitro. METHODS: LN was induced in BALB/c mice via intraperitoneal injection of pristane. Upon treatment with increasing doses of piperine, we assessed renal lesions, measured serum levels of pro-inflammatory cytokines, and examined expressions of key components of NLRP3 inflammasome in kidney...
October 30, 2018: International Immunopharmacology
Xiao-Ying Zhang, Zhi-Peng Xu, Wei Wang, Jiang-Bei Cao, Qiang Fu, Wei-Xing Zhao, Yang Li, Xiu-Lin Huo, Li-Ming Zhang, Yun-Feng Li, Wei-Dong Mi
Neuroinflammation is believed to be one of the primary causes of cognitive impairment. Previous studies showed that the antioxidant vitamin C (Vit C) performs many beneficial functions such as immunostimulant and anti-inflammatory actions, but its role in inflammatory cognitive impairment is unclear. In the current study, we investigated the effect and possible mechanism of action of Vit C in lipopolysaccharide (LPS)-induced cognitive impairment. Intracerebroventricular LPS-induced memory impairment was used as the model for neuroinflammatory cognitive dysfunction...
October 30, 2018: International Immunopharmacology
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