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International Immunopharmacology

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https://www.readbyqxmd.com/read/28926774/concurrent-administration-effect-of-antibiotic-and-anti-inflammatory-drugs-on-the-immunotoxicity-of-bacterial-endotoxins
#1
Azza M El Amir, Dalia G Tanious, Hanaa A Mansour
Pseudomonas aeruginosa (P. aeruginosa) is a gram-negative bacterium that causes a variety of diseases in compromised hosts. Bacterial endotoxins such as lipopolysaccharide (LPS) are the major outer surface membrane components that are present in almost all gram-negative bacteria and act as extremely strong stimulators of innate immunity and inflammation of the airway. This study was undertaken to determine the effect of combined administration of Gentamicin (GENT) as an antibiotic and Dexamethasone (DEXA) as an anti-inflammatory drug on some immunological and histological parameters...
September 16, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28926773/dectin-1-is-essential-for-il-1%C3%AE-production-through-jnk-activation-and-apoptosis-in-aspergillus-fumigatus-keratitis
#2
Kelan Yuan, Guiqiu Zhao, Chengye Che, Cui Li, Jing Lin, Guoqiang Zhu, Kun He
PURPOSE: To investigate the role of phosphorylated JNK in Dectin-1-induced IL-1β production and the role of Dectin-1 in apoptosis in mouse Aspergillus fumigatus (A. fumigatus) keratitis. METHODS: Mice corneas were pretreated with Dectin-1 siRNA or SP600125 (the inhibitor of JNK) before A. fumigatus infection. THP-1 macrophages were preincubated with SP600125 before the stimulation of A. fumigatus conidia. Dectin-1, IL-1β, JNK, Bax, Bcl-2, cytochrome-c (cyt-c), caspase-9, caspase-8 and caspase-3 expressions were tested by PCR, Western blot, or Immunofluorescence staining...
September 16, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28918288/th9-cells-promote-antitumor-immunity-via-il-9-and-il-21-and-demonstrate-atypical-cytokine-expression-in-breast-cancer
#3
Fa-Ping You, Jian Zhang, Tao Cui, Rui Zhu, Chong-Qing Lv, Hai-Tao Tang, Di-Wen Sun
Breast cancer is a major cause of cancer-related death in women. Antitumor T cell responses play critical therapeutic roles, including direct cytotoxicity mediated by CD8(+) T cells and immunomodulatory roles mediated by CD4(+) T cells. The IL-9-expressing Th9 cells are recently found to present antitumor immunity in melanoma and lung adenocarcinoma. In this study, we found that IL-9 expression in the serum and in circulating CD4(+) T cells were significantly upregulated in breast cancer patients compared to healthy controls...
September 14, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28915439/alpha-mangostin-suppresses-interleukin-1%C3%AE-induced-apoptosis-in-rat-chondrocytes-by-inhibiting-the-nf-%C3%AE%C2%BAb-signaling-pathway-and-delays-the-progression-of-osteoarthritis-in-a-rat-model
#4
Tianlong Pan, Rong Chen, Dengying Wu, Ningyu Cai, Xuchao Shi, Bin Li, Jun Pan
Osteoarthritis (OA) is a chronic degenerative joint disease that is characterized by progressive joint dysfunction and pain. Apoptosis and catabolism in chondrocytes play critical roles in the development of OA. Alpha-Mangostin (α-MG), one of the main components of the mangosteen, has been reported to have anti-apoptotic, anti-inflammatory and antioxidant effects. We investigated the therapeutic effects of α-MG on OA through experiments on rat chondrocytes in vitro and in a rat model of OA induced by destabilization of the medial meniscus (DMM)...
September 12, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28910745/mir-200bc-429-cluster-alleviates-inflammation-in-iga-nephropathy-by-targeting-tweak-fn14
#5
Yong Guo, Yuanjiang Liao
Immunoglobulin A nephropathy (IgAN) is one of the most common glomerular diseases worldwide. Various studies have identified a host of microRNAs (miRNAs) abnormally expressed in IgAN and might affect the pathogenesis and progression of IgAN. However, miR-200bc/429 cluster in the pathopoiesis of IgAN remains poorly understood. For this study, we found that miR-200bc/429 cluster is downregulated in IgAN tissues and IgAN podocytes and HK2 cells compared with their matched controls respectively. In addition, overexpression of miR-200bc/429 cluster in IgAN podocytes and HK2 cells could attenuate the release of inflammatory cytokines MCP-1, IL-6 and RANTES...
September 11, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28910744/advanced-glycation-end-products-induced-il-6-and-vegf-a-production-and-apoptosis-in-osteocyte-like-mlo-y4-cells-by-activating-rage-and-erk1-2-p38-and-stat3-signalling-pathways
#6
Helin Chen, Wenjia Liu, Xiangnan Wu, Min Gou, Jiefei Shen, Hang Wang
Advanced glycation end products (AGEs) are involved in osteopenia in people with diabetes and the elderly. Interleukin-6 (IL-6) and vascular endothelial growth factor-A (VEGF-A) are potent regulators of bone metabolism, and in bone tissue, osteocytes are an important source of these regulators. However, whether AGEs can directly regulate IL-6 and VEGF-A secretion by osteocytes is unknown. In this study, we evaluated the effect of AGEs on IL-6 and VEGF- A production as well as apoptosis in osteocyte-like MLO-Y4 cells...
September 11, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28898770/immunoglobulin-replacement-therapy-in-primary-and-secondary-antibody-deficiency-the-correct-clinical-approach
#7
REVIEW
Antonio Pecoraro, Ludovica Crescenzi, Francescopaolo Granata, Arturo Genovese, Giuseppe Spadaro
Immunoglobulin therapy is the administration of human polyvalent IgG and represents the most effective treatment to prevent recurrent infections in antibody deficiency patients. Primary antibody deficiency represents the main indication of immunoglobulin replacement therapy and includes a wide range of disorders characterized by impaired antibody production in response to pathogens and recurrent infections. However, not all primary antibody deficiency patients require immunoglobulin replacement. Indeed, immunoglobulin preparations are expensive and, once prescribed, usually result in lifelong therapy...
September 9, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28898769/lox-1-is-involved-in-il-1%C3%AE-production-and-extracellular-matrix-breakdown-in-dental-peri-implantitis
#8
Chengye Che, Jie Liu, Lei Ma, Huirong Xu, Na Bai, Qian Zhang
PURPOSE: To explore whether lectin-type oxidized LDL receptor 1 (LOX-1), interleukin 1 beta (IL-1β), matrix metalloproteinase 2 (MMP2) and matrix metalloproteinase 9 (MMP9) are involved in the nosogenesis of human dental peri-implantitis and determine the role of LOX-1 in IL-1β, MMP2 and MMP9 production in response to Porphyromonas gingivalis. METHODS: Peri-implant crevicular fluid (PICF) was collected from ten patients with healthy implants and ten patients with peri-implantitis...
September 9, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28898768/immune-enhancing-effects-of-polysaccharides-extracted-from-lilium-lancifolium-thunb
#9
REVIEW
Guifang Pan, Zhongwen Xie, Shixia Huang, Yuling Tai, Qingshuang Cai, Wei Jiang, Jiameng Sun, Yi Yuan
Lilium lancifolium Thunb. is a Chinese traditional plant with various health benefits. In this study, we purified and characterized the water-soluble polysaccharide fraction (LLP-1A) of L. lancifolium. We also investigated the in vitro immune-enhancing activity of LLP-1A in macrophages and the underlying molecular mechanism. Results showed that LLP-1A was mainly composed of mannose and glucose at a molar ratio of 1.77:1, and its molecular weight was approximately 78.61kDa. The Fourier transform-infrared spectra of LLP-1A also revealed typical polysaccharide characteristics: the presence of uronic acid, pyranose rings and β-glycosidic bonds...
September 9, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28888779/anti-inflammatory-and-antioxidant-potential-of-guaianolide-isolated-from-cyathocline-purpurea-role-of-cox-2-inhibition
#10
Urmila U Tambewagh, Amit D Kandhare, Varsha S Honmore, Parag P Kadam, Vijay M Khedkar, Subhash L Bodhankar, Supada R Rojatkar
BACKGROUND: Inflammation activated by oxidative stress can cause various diseases, such as asthma, rheumatoid arthritis, cancer, diabetes, etc. Plant constituents with sesquiterpene lactones possess antioxidant and anti-inflammatory properties. AIM: To determine the antioxidant and anti-inflammatory potential of isolated phytoconstituent from Cyathocline purpurea Buch-Ham ex D (CP). Don in laboratory animals. Furthermore, to understand the interactions involved in the binding of this compound to cyclooxygenase-2 (COX-2) via computational docking...
September 8, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28888780/berberine-suppresses-lps-induced-inflammation-through-modulating-sirt1-nf-%C3%AE%C2%BAb-signaling-pathway-in-raw264-7-cells
#11
Hao Zhang, Yun Shan, Yun Wu, Chuanchong Xu, Xizhong Yu, Juan Zhao, Jing Yan, Wenbin Shang
Chronic inflammation is a major contributing factor in the pathogenesis of many diseases. Natural product berberine (BBR) exhibits potent anti-inflammatory effect in vitro and in vivo, while the underlying mechanisms remain elusive. Sirt1, a NAD(+)-dependent protein deacetylase, was recently found to play an important role in modulating the development and progression of inflammation. Thus, we speculate that Sirt1 might mediate the inhibitory effect of BBR on inflammation. In LPS-stimulated RAW264.7 macrophages, BBR treatment significantly downregulated the expression of proinflammatory cytokines such as MCP-1, IL-6 and TNF-α...
September 7, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28888778/mincle-inhibits-neutrophils-and-macrophages-apoptosis-in-a-fumigatus-keratitis
#12
Jing Lin, Kun He, Guiqiu Zhao, Cui Li, Liting Hu, Guoqiang Zhu, Yawen Niu, Guipei Hao
PURPOSE: To determine whether macrophage inducible C-type lectin (Mincle) regulates neutrophils and macrophages apoptosis in A. fumigatus keratitis. MATERIALS AND METHODS: A murine model (C57BL/6) of fungal keratitis (AF) was established by gently scraping corneal central epithelium, smearing A. fumigatus on the epithelium surface and covering the eye with contact lenses. AF cell model was established by extracting neutrophils (PMN) and macrophages, and then infecting cells with A...
September 7, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28886583/protective-effects-of-wogonin-against-disease-progression-in-different-hepatic-pathological-conditions
#13
LETTER
Shailendra Kapoor
No abstract text is available yet for this article.
September 5, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28886582/protective-effects-of-ghrelin-in-ventilator-induced-lung-injury-in-rats
#14
Guang Li, Jiao Liu, Wen-Fang Xia, Chen-Liang Zhou, Li-Qiong Lv
Ghrelin has exhibited potent anti-inflammatory effects on various inflammatory diseases. The aim of this study was to investigate the potential effects of ghrelin on a model of ventilator-induced lung injury (VILI) established in rats. Male Sprague-Dawley rats were randomly divided into three groups: low volume ventilation (LV, Vt=8ml/kg) group, a VILI group (Vt=30ml/kg), and a VILI group pretreated with ghrelin (GH+VILI). For the LV group, for the VILI and GH+VILI groups, the same parameters were applied except the tidal volume was increased to 40ml/kg...
September 5, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28886581/skullcapflavone-ii-attenuates-ovalbumin-induced-allergic-rhinitis-through-the-blocking-of-th2-cytokine-production-and-mast-cell-histamine-release
#15
Thi Tho Bui, Chun Hua Piao, Chang Ho Song, Ok Hee Chai
Allergic rhinitis is a common heterogeneous chronic upper airway disorder and is an IgE-mediated inflammation characterized by one or more nasal symptoms such as sneezing, itching, nasal discharge, rhinorrhea, post nasal drainage and nasal blockage. In the present study, the effects of skullcapflavone II (SCFII) on upper airway inflammation, Th2 cytokines, and NF-κB signaling in an ovalbumin (OVA)-induced allergic rhinitis (AR) murine model in vivo were investigated. OVA-induced AR mice increased nasal symptoms, eosinophils and mast cells infiltration into nasal cavity, OVA-specific IgE/IgG1 and histamine in serum, Th2 cytokines including IL-13 and GATA3, and NF-κB signaling in NALF and lung homogenate...
September 5, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28866026/the-peroxisome-proliferator-activated-receptor-pan-agonist-bezafibrate-suppresses-microvascular-inflammatory-responses-of-retinal-endothelial-cells-and-vascular-endothelial-growth-factor-production-in-retinal-pigmented-epithelial-cells
#16
Ayumi Usui-Ouchi, Yasuo Ouchi, Nobuyuki Ebihara
A randomized clinical trial showed the beneficial effects of the selective peroxisome proliferator-activated receptor (PPAR)-α agonist, fenofibrate, in reducing the progression of diabetic retinopathy independent of serum lipid levels. All subtypes of PPAR (PPAR-α, PPAR-γ, and PPAR-β/δ) have been reported to play a key role in microvascular inflammation and angiogenesis. Therefore, the agonistic function of fenofibrate against the PPAR-α has been suggested to contribute to its medicinal effect. Furthermore, bezafibrate is a fibrate drug commonly used as a lipid-lowering agent to treat hyperlipidemia and acts as a pan-agonist of all PPARs subtypes...
August 31, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28863323/ethyl-pyruvate-reverses-development-of-pseudomonas-aeruginosa-pneumonia-during-sepsis-induced-immunosuppression
#17
Wei Chen, Jie Lian, Jing-Jing Ye, Qing-Fei Mo, Jie Qin, Guang-Liang Hong, Long-Wang Chen, Shao-Ce Zhi, Guang-Ju Zhao, Zhong-Qiu Lu
Sepsis is characterized by an innate immune response and the following immune dysfunction which can increase the emergence of secondary infections. Ethyl pyruvate (EP) has multiple immunoregulation functions in several serious illnesses, such as burn injury, severe sepsis and acute respiratory syndrome. However, little data was shown the effect of EP administration on immunosuppression post-CLP and the following secondary infection. The cecal ligation and puncture (CLP) followed by the induction of Pseudomonas aeruginosa (PA) was used as a clinically relevant two-hit model of sepsis...
August 29, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28863322/il-17-contributes-to-the-pathogenesis-of-obliterative-bronchiolitis-via-regulation-of-m1-macrophages-polarization-in-murine-heterotopic-trachea-transplantation-models
#18
Qingshu Meng, Jie Liu, Fang Lin, Luer Bao, Yuyu Jiang, Liang Zheng, Jinjun Tie, Lin Zhang, Xiaoting Liang, Lu Wei, Yuan Li, Huimin Fan, Xiaohui Zhou
Acute allograft rejection is a principal conundrum in lung obliterative bronchiolitis (OB). Monocytes/macrophages infiltration has been proved to be the main reason for acute rejection. IL-17 contributes to the recruitment and function of macrophages. However, the mechanism of IL-17 underlying OB progression remains elusive. In the present study, we showed that the deficiency of IL-17 attenuated the pathology of murine heterotopic trachea allografts. Compared to WT recipients, IL-17(-/-) mice displayed higher frequency of CD206+ cells and lower ratio of CD86+ cells among F4/80+ macrophages in allografts and spleens on day 7 post heterotopic trachea transplantation...
August 29, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28858725/focus-on-the-therapeutic-efficacy-of-3bnc117-against-hiv-1-in-vitro-studies-in-vivo-studies-clinical-trials-and-challenges
#19
REVIEW
Zhi-Jun Liu, Jing Bai, Feng-Li Liu, Xiang-Yang Zhang, Jing-Zhang Wang
3BNC117, which was discovered in 2011, is a broadly neutralizing antibody (bNAb) and specifically neutralizes the human immunodeficiency virus type-1 (HIV-1) by targeting the CD4-binding site. This is the first comprehensive review that focuses on the role of 3BNC117 in the prevention of HIV-1 and acquired immune deficiency syndrome (AIDS). Briefly, 3BNC117 neutralizes many HIV/SHIV strains in vitro, blocks HIV-1 acquisition in animal models via a pre-exposure prophylaxis, alleviates HIV-1-associated viremia via a post-exposure therapeutic effect, prevents the establishment of latent HIV-1 reservoirs, and induces both humoral and cellular anti-HIV immune responses in vivo...
August 28, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28858724/alpha-mangostin-protects-rat-articular-chondrocytes-against-il-1%C3%AE-induced-inflammation-and-slows-the-progression-of-osteoarthritis-in-a-rat-model
#20
Tianlong Pan, Dengying Wu, Ningyu Cai, Rong Chen, Xuchao Shi, Bin Li, Jun Pan
Osteoarthritis (OA) is a joint disease characterized by inflammation and cartilage degradation. α-Mangostin (α-MG), which can be isolated from the fruit of the tropical evergreen tree Garcinia mangostana-L, is known to have anti-inflammatory properties. The aim of the study was to investigate the use of α-MG in the treatment of OA, using both rat chondrocytes and an OA rat model induced by destabilization of the medial meniscus (DMM). Rat chondrocytes were pretreated with α-MG (0, 1.25, 2.5, and 5.0μg/ml for 24h) prior to stimulation with interleukin-1β (IL-1β) (10ng/ml for 24h)...
August 28, 2017: International Immunopharmacology
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