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Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft

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https://www.readbyqxmd.com/read/28477448/expression-and-distribution-of-leptin-and-its-receptors-in-the-digestive-tract-of-dio-diet-induced-obese-zebrafish
#1
M Mania, L Maruccio, F Russo, F Abbate, L Castaldo, L D'Angelo, P de Girolamo, M C Guerrera, C Lucini, M Madrigrano, M Levanti, A Germanà
The expression and localization of leptin (A and B) and its receptor family in control and diet-induced obese (DIO) adult male zebrafish gut, after 5-weeks overfeeding, administering Artemia nauplii, as fat-rich food, were investigated. Recently, the obese adult zebrafish was considered an experimental model with pathophysiological pathways similar to mammalian obesity. Currently, there are no reports about leptin in fish obesity, or in a state of altered energy balance. By qRT-PCR, leptin A and leptin B expression levels were significantly higher in DIO zebrafish gut than in the control group (CTRL), and the lowest levels of leptin receptor mRNA appeared in DIO zebrafish gut...
May 3, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28455132/garcinia-mangostana-pericarp-extract-protects-against-oxidative-stress-and-cardiovascular-remodeling-via-suppression-of-p47-phox-and-inos-in-nitric-oxide-deficient-rats
#2
Pattanapong Boonprom, Orachorn Boonla, Kanokporn Chayaburakul, Jariya Umka Welbat, Patchareewan Pannangpetch, Upa Kukongviriyapan, Veerapol Kukongviriyapan, Poungrat Pakdeechote, Parichat Prachaney
N(ω)-Nitro-l-arginine methyl ester (l-NAME)-induced hypertension and cardiovascular remodeling are associated with oxidative stress and inflammation. Garcinia mangostana Linn., has been reported to have antioxidant and anti-inflammatory properties. This study investigated whether G. mangostana pericarp extract (GME) could prevent l-NAME-induced hemodynamic alterations, cardiovascular remodeling, oxidative stress and inflammation in rats. Male Sprague-Dawley rats were given 40mg/kg/day of l-NAME in drinking water to induce hypertension, and were simultaneously treated with GME at a dose of 200mg/kg/day...
April 26, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28434911/does-quantity-ensure-quality-standardized-osce-stations-for-outcome-oriented-evaluation-of-practical-skills-at-different-medical-faculties
#3
Iris Schleicher, Karsten Leitner, Jana Juenger, Andreas Moeltner, Miriam Ruesseler, Bernd Bender, Jasmina Sterz, Tina Stibane, Sarah Koenig, Susanne Frankenhauser, Joachim Gerhard Kreuder
BACKGROUND: Practical skills are often assessed using Objective Structured Clinical Skill Exams (OSCE). Nevertheless, in Germany, interchange and agreement between different medical faculties or a general agreement on the minimum standard for passing is lacking. METHODS: We developed standardized OSCE-stations for assessing structured clinical examination of knee and shoulder joint with identical checklists and evaluation standards. These were implemented into the OSCE-course at five different medical faculties...
April 21, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28434910/the-composition-and-biomechanical-properties-of-human-cryopreserved-aortas-pulmonary-trunks-and-aortic-and-pulmonary-cusps
#4
Tereza Kubíková, Petra Kochová, Jan Brázdil, Jaroslav Špatenka, Jan Burkert, Milena Králíčková, Zbyněk Tonar
Human cryopreserved allografts of pulmonary and aortic heart valves, aortas and pulmonary trunks are used for valve replacement. However, it is unknown how the composition of these allografts relate to their mechanical properties. Our aims were to correlate the histological compositions and passive mechanical properties of aortic and pulmonary valves and to observe the microcracks of aortas and pulmonary trunks. The following parameters were quantified: ultimate stress; ultimate strain; Young's modulus of elasticity; valve cusp wall thickness; pulmonary and aortic intima-media thickness; area fraction of elastin, collagen and calcification; and length density of elastic fibres...
April 21, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28385619/medical-students-assessment-of-eduard-pernkopf-s-atlas-topographical-anatomy-of-man
#5
Demetrius M Coombs, Steven J Peitzman
INTRODUCTION: To date, there has been no study examining the perceptions of first-year medical students regarding Eduard Pernkopf's atlas, particularly during their study of gross anatomy and prior to coursework in medical ethics. We present a discussion of Pernkopf's Atlas: Topographical Anatomy of Man from the perspective of U.S. medical students, and sought to determine whether medical students view Pernkopf's Topographical Anatomy of Man as a resource of greater accuracy, detail, and potential educational utility as compared to Netter's Atlas of Human Anatomy...
April 3, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28366507/elaborative-feedback-in-clinical-dental-teaching-an-assessment-from-the-students-perspective
#6
C Olms, H A Jakstat, R Haak
INTRODUCTION: The aim of this prospective learning research study is to examine the impact of structured elaborative feedback in clinical dental skills teaching from the students' perspective. MATERIAL AND METHODS: A total of 60 dental students participated in the study. The mean average age was 23 years (20-40 years), of which 37 were female (61.7%) and 23 male (38.3%). The participants were randomly divided into a study and control group (n=30 each). The curriculum for clinical tooth-shade differentiation is a complete educational module...
March 31, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28365383/a-comparative-study-of-the-effectiveness-of-early-and-delayed-loading-of-short-tissue-level-dental-implants-with-hydrophilic-surfaces-placed-in-the-posterior-section-of-the-mandible-a-preliminary-study
#7
Arkadiusz Makowiecki, Ute Botzenhart, Julia Seeliger, Friedhelm Heinemann, Peter Biocev, Marzena Dominiak
The objective of the present study was to compare the primary and secondary stability of tissue-level short dental titanium implants with polished necks and hydrophilic surfaces of two different designs and manufacturers. The first implant system used (SPI(®)ELEMENT RC INICELL titanium implants, Thommen Medical AG, Grenchen, Switzerland), allowed functional loading 6 weeks after its placement, whereas the second implant system (RN SLActiv(®) tissue-level titanium implants, Straumann GmbH, Fribourg, Germany), was loaded after 15 weeks...
March 30, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28365382/mapping-the-secretome-of-human-chondrogenic-progenitor-cells-with-mass-spectrometry
#8
Sarah Batschkus, Ilian Atanassov, Christof Lenz, Philipp Meyer-Marcotty, Gökhan Cingöz, Christian Kirschneck, Henning Urlaub, Nicolai Miosge
Tissue engineering offers promising perspectives in the therapy of osteoarthritis. In the context of cell-based therapy, chondrogenic progenitor cells (CPCs) may be used to regenerate defects in cartilage tissue. An in-depth characterization of the secretome of CPCs is a prerequisite to this approach. In this study, a method was developed for the qualitative and quantitative analysis of the secretome of undifferentiated and differentiated CPCs. Secreted proteins from cells grown in two-dimensional as well as three-dimensional alginate cultures were extracted and analyzed by liquid chromatography/tandem mass spectrometry (LC-MS/MS)...
March 30, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28365381/the-anterolateral-ligament-all-of-the-knee-part-of-the-iliotibial-tract-or-a-truly-separate-structure
#9
Matthias Brockmeyer, Denis Höfer, Katja Schäfer, Romain Seil, Kurt Becker, Friedrich Paulsen, Dieter Kohn, Thomas Tschernig
In this Short Communication, the issue is discussed whether the recently reported anterolateral ligament of the knee is a unique structure or just part of the iliotibial tract. The presented findings from investigations in body donors support the view of a unique structure.
March 29, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28351529/analysis-of-the-regulation-of-surfactant-phosphatidylcholine-metabolism-using-stable-isotopes
#10
REVIEW
Joost Brandsma, Anthony D Postle
The pathways and mechanisms that regulate pulmonary surfactant synthesis, processing, secretion and catabolism have been extensively characterised using classical biochemical and analytical approaches. These have constructed a model, largely in experimental animals, for surfactant phospholipid metabolism in the alveolar epithelial cell whereby phospholipid synthesised on the endoplasmic reticulum is selectively transported to lamellar body storage vesicles, where it is subsequently processed before secretion into the alveolus...
March 25, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28274804/surface-models-and-gradually-peeled-volume-model-to-explore-hand-structures
#11
Beom Sun Chung, Koojoo Kwon, Byeong-Seok Shin, Min Suk Chung
This study was intended to confirm whether simultaneous examination of surface and volume models contributes to learning of hand structures. Outlines of the skin, muscles, and bones of the right hand were traced in sectioned images of a male cadaver to create surface models of the structures. After the outlines were filled with selected colors, the color-filled sectioned images were stacked to produce a volume model of the hand, from which the skin was gradually peeled. The surface models provided locational orientation of the hand structures such as extrinsic and intrinsic hand muscles, while the peeled volume model revealed the depth of the individual hand structures...
March 17, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28279730/efficacy-of-aflibercept-eylea-%C3%A2-on-inhibition-of-human-vegf-in-vitro
#12
M Schicht, K Hesse, H Schröder, E Naschberger, W Lamprecht, F Garreis, F P Paulsen, L Bräuer
INTRODUCTION: Pathological formation of blood vessels plays a key role in the growth and metastasis of tumors and also in several serious ophthalmological diseases such as wet age-related macular degeneration (AMD) or diabetic retinopathy. In AMD treatment, aflibercept (tradename EYLEA(®)) is used to deactivate the underlying pathological neovascularisation. Aflibercept is a recombinant fusion protein which binds to vascular endothelial growth factor (VEGF) receptors, thereby inhibiting VEGF pathway activation...
March 7, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28279760/paying-respect-to-human-cadavers-we-owe-this-to-the-first-teacher-in-anatomy
#13
Sanjib Kumar Ghosh
Every human cadaver which undergoes anatomical dissection enriches medical science and deserves to be treated with utmost respect. The aim of the present study is to identify the practices followed by medical schools across the globe to ensure that the human cadaver is treated with respect and dignity while it is utilized within the domain of medical education. The article undertakes a review of the literature and takes note of the practice of students taking an oath prior to dissecting cadavers whereby they reflect on their conduct and habits in the dissection room...
March 6, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28279759/what-do-we-know-about-the-structure-of-human-thymic-hassall-s-corpuscles-a-histochemical-immunohistochemical-and-electron-microscopic-study
#14
Renáta Mikušová, Veronika Mešťanová, Štefan Polák, Ivan Varga
Hassall's corpuscles are the most prominent structures in the human thymus. However, relatively few analyses have been performed to determine their function and cellular origins during development. In this study, we evaluated the cellular microenvironment of human thymic Hassall's corpuscles using histochemistry, immunohistochemistry, and transmission electron microscopy. We examined 95 human thymic tissue samples, which were perioperatively obtained from children undergoing cardiac surgery. To characterize the complex cellular microenvironment of human thymic corpuscles, we used a panel of 14 different antibodies to identify discrete cell types...
March 6, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28279731/precuneus-proportions-and-cortical-folding-a-morphometric-evaluation-on-a-racially-diverse-human-sample
#15
Emiliano Bruner, Ana Sofia Pereira-Pedro, Xu Chen, James K Rilling
Recent analyses have suggested that the size and proportions of the precuneus are remarkably variable among adult humans, representing a major source of geometrical difference in midsagittal brain morphology. The same area also represents the main midsagittal brain difference between humans and chimpanzees, being more expanded in our species. Enlargement of the upper parietal surface is a specific feature of Homo sapiens, when compared with other fossil hominids, suggesting the involvement of these cortical areas in recent modern human evolution...
March 6, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28212784/intraspinal-extradural-variations-of-nerve-roots
#16
Viktor Matejčík, Zora Haviarová, Andrej Šteňo, Roman Kuruc, Juraj Šteňo
INTRODUCTION: The aim of this work is to point out the intraspinal extradural anatomical variations of nerve roots and their possible participation in radiculopathy. METHODS: The anatomical study was performed in 33 cadavers at a mean age of 46.5 and up to 24h from death. All extradural anastomoses between nerve roots were excised and examined histologically for the presence or absence of nervous tissue. The type of the plexus was defined by subtracting from the root C2...
March 5, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28351530/structure-genetics-and-function-of-the-pulmonary-associated-surfactant-proteins-a-and-d-the-extra-pulmonary-role-of-these-c-type-lectins
#17
REVIEW
Frederico Vieira, Johannes W Kung, Faizah Bhatti
The collectins family encompasses several collagenous Ca(2+)-dependent defense lectins that are described as pathogen recognition molecules. They play an important role in both adaptive and innate immunity. Surfactant proteins A and D are two of these proteins which were initially discovered in association with surfactant in the pulmonary system. The structure, immune and inflammatory functions, and genetic variations have been well described in relation to their roles, function and pathophysiology in the pulmonary system...
May 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28034695/aberrant-lung-remodeling-in-a-mouse-model-of-surfactant-dysregulation-induced-by-modulation-of-the-abca3-gene
#18
Michael F Beers, Lars Knudsen, Yaniv Tomer, Julian Maronn, Ming Zhao, Matthias Ochs, Surafel Mulugeta
The lipid transporter, ATP binding cassette class A3 (ABCA3), plays a critical role in the biogenesis of alveolar type 2 (AT2) cell lamellar bodies (LBs). A relatively large number of mutations in the ABCA3 gene have been identified in association with diffuse parenchymal lung disease (DPLD), the most common of which is a missense mutation (valine substitution for lysine at residue 292 (ABCA3(E292V))) that leads to functional impairment of the transporter in vitro. The consequences of ABCA3(E292)(V) gene expression in vivo are unknown...
March 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/27987402/efficacy-of-human-umbilical-cord-derived-mesenchymal-stem-cells-in-treatment-of-rat-bone-marrow-exposed-to-gamma-irradiation
#19
Hanaa S E Mousa, Sally M Shalaby, Zienab A Gouda, Fayza E Ahmed, Aisha A El-Khodary
To assess the therapeutic effects of the human umbilical cord blood (hUCB) derived mesenchymal stem cells (MSCs) on rat bone marrow (BM) exposed to gamma rays, 3 groups (n=15 each) of adult male Wistar albino rats were utilized as follows: the 1st group received PBS (control group), the 2nd group was exposed to gamma rays 1.04Gy/min (R group) and the 3rd group exposed to same dose as RG and injected hUCB-MSCs. The BM of femurs was processed for histological and immunohistochemical staining with proliferating cell nuclear antigen antibody (PCNA), anti human CD105 and anti human CD34...
March 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/27986642/anatomic-characteristics-of-the-mitral-isthmus-region-the-left-atrial-appendage-isthmus-as-a-possible-ablation-target
#20
Mateusz K Hołda, Mateusz Koziej, Jakub Hołda, Kamil Tyrak, Katarzyna Piątek, Filip Bolechała, Wiesława Klimek-Piotrowska
The mitral isthmus is a part of the postero-inferior area of the lateral left atrial wall located between the mitral annulus and the left inferior pulmonary vein ostium. Linear ablation lesions are created within the mitral isthmus for the invasive treatment of left atrial arrhythmias. However, the anatomy of this region is not fully understood. The aim of this study has been to provide a detailed morphometric description of the mitral isthmus region and to propose another possible isthmus within the investigated heart area that may serve as a potential new ablation target...
March 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
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