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Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft

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https://www.readbyqxmd.com/read/28034695/aberrant-lung-remodeling-in-a-mouse-model-of-surfactant-dysregulation-induced-by-modulation-of-the-abca3-gene
#1
Michael F Beers, Lars Knudsen, Yaniv Tomer, Julian Maronn, Ming Zhao, Matthias Ochs, Surafel Mulugeta
The lipid transporter, ATP binding cassette class A3 (ABCA3), plays a critical role in the biogenesis of alveolar type 2 (AT2) cell lamellar bodies (LBs). A relatively large number of mutations in the ABCA3 gene have been identified in association with diffuse parenchymal lung disease (DPLD), the most common of which is a missense mutation (valine substitution for lysine at residue 292 (ABCA3(E292V))) that leads to functional impairment of the transporter in vitro. The consequences of ABCA3(E292)(V) gene expression in vivo are unknown...
December 26, 2016: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/27987402/efficacy-of-human-umbilical-cord-derived-mesenchymal-stem-cells-in-treatment-of-rat-bone-marrow-exposed-to-gamma-irradiation
#2
Hanaa S E Mousa, Sally M Shalaby, Zienab A Gouda, Fayza E Ahmed, Aisha A El-Khodary
To assess the therapeutic effects of the human umbilical cord blood (hUCB) derived mesenchymal stem cells (MSCs) on rat bone marrow (BM) exposed to gamma rays, 3 groups (n=15 each) of adult male Wistar albino rats were utilized as follows: the 1st group received PBS (control group), the 2nd group was exposed to gamma rays 1.04Gy/min (R group) and the 3rd group exposed to same dose as RG and injected hUCB-MSCs. The BM of femurs was processed for histological and immunohistochemical staining with proliferating cell nuclear antigen antibody (PCNA), anti human CD105 and anti human CD34...
December 14, 2016: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/27986642/anatomic-characteristics-of-the-mitral-isthmus-region-the-left-atrial-appendage-isthmus-as-a-possible-ablation-target
#3
Mateusz K Hołda, Mateusz Koziej, Jakub Hołda, Kamil Tyrak, Katarzyna Piątek, Filip Bolechała, Wiesława Klimek-Piotrowska
The mitral isthmus is a part of the postero-inferior area of the lateral left atrial wall located between the mitral annulus and the left inferior pulmonary vein ostium. Linear ablation lesions are created within the mitral isthmus for the invasive treatment of left atrial arrhythmias. However, the anatomy of this region is not fully understood. The aim of this study has been to provide a detailed morphometric description of the mitral isthmus region and to propose another possible isthmus within the investigated heart area that may serve as a potential new ablation target...
December 13, 2016: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/27986641/implementation-of-clinical-references-for-undergraduates-in-anatomy
#4
André Kranz, Ingo Bechmann, Christine Feja, Kay-Rüdiger Kohlhaw, Thomas Bürkigt, Lisa Lippross, Nora Dietze, Sabine Löffler
This study evaluates the implementation of clinical references in undergraduate medical education. For this purpose, images of typical diagnostic, intraoperative and clinical findings were integrated into two different teaching formats and adapted to the learning objectives of the Institute of Anatomy in Leipzig. Paper based questionnaires were used to evaluate the status quo (without clinical images) and the optimal time of implementation, as well as the benefit for the students of human medicine. Three test groups were drawn from two preclinical semesters (2014 and 2015)...
December 13, 2016: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/27986640/microscopic-observations-show-invasion-of-inflammatory-cells-in-the-limb-blastema-and-epidermis-in-pre-metamorphic-frog-tadpoles-which-destroy-the-apical-epidermal-cap-and-impede-regeneration
#5
Lorenzo Alibardi
Some limb regeneration in tadpoles of Rana dalmatina occurs at stages 44-48 when small hind-limbs are present while scarring occurs at stages 51-52 when forelimbs have developed and metamorphosis is approaching. Ultrastructural analysis of cells forming the regenerating blastema detects mesenchymal cells and an Apical Epidermal Cap (AEC) in regenerating limb blastema 5-6 days post-amputation at stages 46-48. In contrast, granulocytes and numerous macrophages and lymphocytes prevail over mesenchymal cells in limb blastema at stages 51-52, which are destined to form scars...
December 13, 2016: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/27986617/accuracy-and-efficiency-of-computer-aided-anatomical-analysis-using-3d-visualization-software-based-on-semi-automated-and-automated-segmentations
#6
Gao An, Li Hong, Xiao-Bing Zhou, Qiong Yang, Mei-Qing Li, Xiang-Yang Tang
OBJECTIVE: We investigated and compared the functionality of two 3D visualization software provided by a CT vendor and a third-party vendor, respectively. Using surgical anatomical measurement as baseline, we evaluated the accuracy of 3D visualization and verified their utility in computer-aided anatomical analysis. METHODS: The study cohort consisted of 50 adult cadavers fixed with the classical formaldehyde method. The computer-aided anatomical analysis was based on CT images (in DICOM format) acquired by helical scan with contrast enhancement, using a CT vendor provided 3D visualization workstation (Syngo) and a third-party 3D visualization software (Mimics) that was installed on a PC...
December 13, 2016: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/27986616/thermogenesis-fatty-acid-synthesis-with-oxidation-and-inflammation-in-the-brown-adipose-tissue-of-ob-ob-mice
#7
Fabiane Ferreira Martins, Thereza Cristina Lonzetti Bargut, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda
Brown adipose tissue (BAT) is specialized in heat production, but its metabolism in ob/ob mice is still a matter of debate. We aimed to verify ob/ob mice BAT using C57Bl/6 male mice (as the wild-type, WT) and leptin-deficient ob/ob mice (on the C57Bl/6 background strain), at three months of age (n=10/group). At euthanasia, animals had their interscapular BAT weighed, and prepared for analysis (Western blot, and RT-qPCR). In comparison with the WT group, the ob/ob group showed reduced thermogenic signaling markers (gene expression of beta 3-adrenergic receptor, beta3-AR; PPARgamma coactivator 1 alpha, PGC1alpha, and uncoupling protein 1, UCP1)...
December 13, 2016: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/27986615/-i-just-realized-that-something-happened-to-me-today-an-innovative-educational-approach-to-support-students-in-dealing-with-the-dissection-course-death-and-dying
#8
Simone Weyers, Thorsten Noack, Gerd Rehkämper, Ursula Wenzel-Meyburg, Christian Schulz, Andrea Schmitz
BACKGROUND AND AIM: The dissection course is an essential part of preclinical medical education. At the Medical Faculty of Duesseldorf, a required elective course has been developed over three semesters with the aim of encouraging students to reflect on their experiences in the dissection course and offering them support in dealing with aspects of death and dying. The aim of this paper is to present this educational approach and the student evaluations. METHODS AND RESULTS: The educational concept follows a peer group approach and is comprised of several components spanning three semesters: introductory lectures, tours of the dissection hall and clinical wards, an online diary, and reflection groups...
December 13, 2016: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/27986614/overview-of-retinal-differentiation-potential-of-mesenchymal-stem-cells-a-promising-approach-for-retinal-cell-therapy
#9
REVIEW
Hossein Salehi, Noushin Amirpour, Shahnaz Razavi, Ebrahim Esfandiari, Reihaneh Zavar
Retinal disease caused by retinal cell apoptosis leads to irreversible vision loss. Stem cell investigation efforts have been made to solve and cure retinal disorders. There are several sources of stem cells which have been used in these experiments. Numerous studies demonstrated that transplanted stem cells can migrate into and integrate in different layers of retina. Among these, mesenchymal stem cells (MSCs) were considered a promising source for cell therapy. Here, we review the literature assessing the potential of MSCs to differentiate into retinal cells in vivo and in vitro as well as their clinical application...
December 13, 2016: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/27986613/oxygen-flux-reduces-cux1-positive-neurons-and-cortical-growth-in-a-gestational-rodent-model-of-growth-restriction
#10
Elaine Fletcher, Jean Wade, Petrina A Georgala, Trudi L Gillespie, David J Price, Elizabeth Pilley, Julie-Clare Becher
BACKGROUND: The mammalian cerebral cortex forms in an inside-out manner, establishing deep cortical layers before superficial layers and is regulated by transcription factors which influence cell differentiation. Preterm birth interrupts the trajectory of normal neurodevelopment and adverse perinatal exposures have been implicated in cortical injury. We hypothesise that growth restriction (GR) and fluctuating hyperoxia (ΔO2) impair cortical laminar development. METHODS: Sprague-Dawley rats received 18% (non-restricted, NR) or 9% (growth restricted, GR) protein diet from E15-P7...
December 13, 2016: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/27886866/corrigendum-to-the-effect-of-different-drugs-on-the-preparation-and-biological-outcomes-of-plasma-rich-in-growth-factors-ann-anat-196-2014-423-429
#11
Eduardo Anitua, María Troya, Mari Mar Zalduendo, Gorka Orive
No abstract text is available yet for this article.
November 26, 2016: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/27893968/interprofessional-approach-for-teaching-functional-knee-joint-anatomy
#12
Jakob J Meyer, Markus M Obmann, Marianne Gießler, Dominik Schuldis, Ann-Kathrin Brückner, Peter C Strohm, Florian Sandeck, Björn Spittau
Profound knowledge in functional and clinical anatomy is a prerequisite for efficient diagnosis in medical practice. However, anatomy teaching does not always consider functional and clinical aspects. Here we introduce a new interprofessional approach to effectively teach the anatomy of the knee joint. The presented teaching approach involves anatomists, orthopaedists and physical therapists to teach anatomy of the knee joint in small groups under functional and clinical aspects. The knee joint courses were implemented during early stages of the medical curriculum and medical students were grouped with students of physical therapy to sensitize students to the importance of interprofessional work...
November 25, 2016: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/27870925/quantitative-and-qualitative-analysis-of-student-tutors-as-near-peer-teachers-in-the-gross-anatomy-course
#13
J Walser, A Horneffer, W Oechsner, M Huber-Lang, S Gerhardt-Szep, A Boeckers
INTRODUCTION: Peer teaching is a well-established teaching method in medical education. During the 2012/13 winter term, the Institute of Anatomy and Cell Biology in Ulm, Germany, introduced a longitudinal didactics program ("Train the Tutor": TtT) to train student tutors as near-peer teachers (NPT) in the dissection course (DC). Twenty-three of 38 tutors participated in the programme. Our study describes the educational concept and the NPTs' activities in the dissection course. METHODS: NPTs documented their activities on a daily basis in the form of semi-structured reports...
November 18, 2016: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/27838560/occurrence-and-colocalization-of-surfactant-proteins-a-b-c-and-d-in-the-developing-and-adult-rat-brain
#14
Stefan Schob, Julia Dieckow, Michael Fehrenbach, Nicole Peukert, Alexander Weiss, Dietrich Kluth, Ulrich Thome, Ulf Quäschling, Martin Lacher, Matthias Preuß
BACKGROUND: Surfactant proteins (SP's) have been described as inherent proteins of the human central nervous system (CNS). Their distribution pattern in brain tissue and altered cerebrospinal fluid (CSF) - concentrations in different CNS pathologies are indicative of their immunological and rheological importance. The aim of this study has been to investigate when - compared to the lungs - SP's are expressed in the developing rat brain and which functional components in the CNS participate in their production...
November 10, 2016: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/27838561/combined-maceration-procedure-permits-advanced-microsurgical-dissection-of-thiel-embalmed-specimens
#15
Hannes Bangerter, Susanne Boemke, Raphael Röthlisberger, Valerie Schwartz, Mathias Bergmann, Michael D Müller, Valentin Djonov
INTRODUCTION: Due to the realistic colour, texture conservation and preservation of biomechanical properties, Thiel-embalming is becoming the main embalming procedure for clinical courses and research based on human cadaver material. The aim of this study is to establish a new procedure that allows advanced microdissection of small vessels and intraorganic nerves in Thiel-embalmed material. MATERIAL AND METHODS/RESULTS: After a classical gross anatomical dissection, human hemipelves underwent repetitive application of 3 consecutive steps: (i) maceration with alloy of nitric acid and MiliQ water 1:10 for 24-48h...
November 9, 2016: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/27838559/interactive-effects-of-periodontitis-and-orthodontic-tooth-movement-on-dental-root-resorption-tooth-movement-velocity-and-alveolar-bone-loss-in-a-rat-model
#16
Christian Kirschneck, Jochen Fanghänel, Ulrich Wahlmann, Michael Wolf, J Camilo Roldán, Peter Proff
BACKGROUND: Many adult orthodontic patients suffer from chronic periodontitis with recurrent episodes of active periodontal inflammation. As their number is steadily increasing, orthodontists are more and more frequently challenged by respective treatment considerations. However, little is currently known regarding interactive effects on undesired dental root resorption (DRR), tooth movement velocity, periodontal bone loss and the underlying cellular and tissue reactions. MATERIAL AND METHODS: A total of 63 male Fischer344 rats were used in three consecutive experiments employing 21 animals each (A/B/C), randomly assigned to 3 experimental groups (n=7, 1/2/3), respectively: (A) CBCT; (B) histology/serology; (C) RT-qPCR-(1) control; (2) orthodontic tooth movement (OTM) of the first/second upper left molars (NiTi coil spring, 0...
November 9, 2016: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/27838558/ceremonies-of-gratitude-following-the-dissection-course-a-report-on-procedures-in-departments-of-anatomy-in-german-speaking-countries
#17
R Pabst, A Schmiedl, S Schrieber, T Tschernig, V C Pabst
The departments of anatomy in Germany, Austria and the German-speaking part of Switzerland were sent comprehensive (18 items) questionnaires requesting details on memorial ceremonies held at the close of the dissection course in the medical curriculum, including objectives, organization, number of participants and the role of the medical students. The response rate was very high (95%). In more than 95% of instances a ceremony is held, initiated mainly after 1970. The titles of the ceremony range from commemoration ceremony (42%), service of mourning (19%) memorial service (19%) to ceremony of gratitude (7%)...
November 9, 2016: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/27837653/behavior-of-sphingomyelin-and-ceramide-in-a-tear-film-lipid-layer-model
#18
Agnieszka Olżyńska, Lukasz Cwiklik
Tear film lipid layer is a complex lipid mixture forming the outermost interface between eye and environment. Its key characteristics, such as surface tension and structural stability, are governed by the presence of polar lipids. The origin of these lipids and exact composition of the mixture are still elusive. We focus on two minor polar lipid components of the tear film lipid later: sphingomyelin and ceramide. By employing coarse grain molecular dynamics in silico simulations accompanied by Langmuir balance experiments we provide molecular-level insight into behavior of these two lipids in a tear film lipid layer model...
November 9, 2016: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/27836800/sex-and-age-dependence-of-region-and-layer-specific-knee-cartilage-composition-spin-spin-relaxation-time-in-healthy-reference-subjects
#19
Wolfgang Wirth, Susanne Maschek, Felix Eckstein
Compositional measures of articular cartilage are accessible in vivo by magnetic resonance imaging (MRI) based relaxometry and cartilage spin-spin transverse relaxation time (T2) has been related to tissue hydration, collagen content and orientation, and mechanical (functional) properties of articular cartilage. The objective of the current study was therefore to evaluate subregional variation, and sex- and age-differences, in laminar (deep and superficial) femorotibial cartilage T2 relaxation time in healthy adults...
November 9, 2016: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/27777116/digital-preservation-of-anatomical-variation-3d-modeling-of-embalmed-and-plastinated-cadaveric-specimens-using-uct-and-mri
#20
Colin W Moore, Timothy D Wilson, Charles L Rice
Anatomy educators have an opportunity to teach anatomical variations as a part of medical and allied health curricula using both cadaveric and three-dimensional (3D) digital models of these specimens. Beyond published cadaveric case reports, anatomical variations identified during routine gross anatomy dissection can be powerful teaching tools and a medium to discuss several anatomical sub-disciplines from embryology to medical imaging. The purpose of this study is to document how cadaveric anatomical variation identified during routine dissection can be scanned using medical imaging techniques to create two-dimensional axial images and interactive 3D models for teaching and learning of anatomical variations...
January 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
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