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Heart, Lung & Circulation

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https://www.readbyqxmd.com/read/29459218/clinical-and-angiographic-predictors-of-mortality-in-sudden-cardiac-arrest-patients-having-cardiac-catheterisation-a-single-centre-registry
#1
James Xu, Leia Hee, Andrew Hopkins, Craig P Juergens, Sidney Lo, John K French, Christian J Mussap
BACKGROUND: Immediate cardiac catheterisation (CC) is recommended in ST-elevation myocardial infarction (STEMI) following sudden cardiac arrest (SCA). Guidelines advise urgent CC for SCA patients without-STEMI, at clinician discretion. We examined the clinical and angiographic factors predicting mortality in SCA patients having CC. METHODS: Consecutive SCA patients having CC at Liverpool Hospital, Sydney (January 2011-September 2015) were retrospectively analysed...
February 8, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29454582/predictors-and-outcomes-of-cardiac-surgery-associated-delirium-a-single-centre-retrospective-cohort-study
#2
Daryl Jones, George Matalanis, Johan Mårtensson, Raymond Robbins, Margaret Shaw, Siven Seevanayagam, Dean Cowie, Rinaldo Bellomo
BACKGROUND: The predictors and independent outcome association of delirium after cardiac surgery are important and yet poorly characterised. METHODS: We performed a retrospective observational study of cardiac surgery patients between January 2009 and March 2016. We defined delirium using ICD-10 diagnostic codes. Multivariable analysis was conducted to find independent associations between baseline variables, delirium, and key clinical outcomes. RESULTS: We studied 2447 study patients (28...
February 8, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29449079/cost-effectiveness-of-ivabradine-in-the-treatment-of-chronic-heart-failure
#3
Michael A Adena, Gary Hamann, Andrew P Sindone
BACKGROUND: In the Systolic Heart failure treatment with the If inhibitor Trial (SHIFT) randomised placebo-controlled trial, ivabradine was shown to reduce hospital admissions for worsening heart failure (HF) and deaths due to HF in patients with symptomatic systolic HF and an elevated resting heart rate (HR). This analysis evaluates the cost effectiveness of adding ivabradine to optimal standard HF treatment in patients with a HR≥77 bpm. METHODS: A Markov model was developed to assess the impact of ivabradine on mean survival and quality of life over a patient's lifetime (10 years)...
February 8, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29433992/changes-in-statin-prescription-patterns-in-patients-admitted-to-an-australian-geriatric-subacute-unit
#4
Samer Noaman, Omar Al-Mukhtar, Sheri Abramovic, Hanin Mohammed, Cheng Yee Goh, Claire Long, Christopher Neil, Edward Janus, Nicholas Cox, William Chan
BACKGROUND: Assessment of demographic and clinical factors influencing the decision of statin discontinuation in the elderly population admitted to subacute geriatric unit. The aim of this study is to assess the clinical factors impacting the decision-making process of statin discontinuation in the elderly. METHODS: We retrospectively assessed changes in statin discontinuation and prescription among patients (≥60 years old) discharged from a geriatric evaluation and management unit by reviewing hospital digital medical records at Western Health - The Williamstown Hospital over a 12-month period from 4 February 2012 until 4 February 2013 inclusive...
January 31, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29428202/pet-suv-max-and-upstaging-of-lung-cancer
#5
Shipra Verma, Justin Chan, Chong Chew, Christopher Schultz
BACKGROUND: Lung cancers managed surgically with curative intent are sometimes upstaged postoperatively. The potential contributions from surgical waiting time and primary tumour 18F-FDG avidity on positron emission tomography (PET)/computed tomography (CT) are unknown. METHODS: We reviewed the records of 153 Royal Adelaide Hospital surgical patients with primary lung cancers from 2013 to 2016 who had preoperative staging combining CT, 18F-FDG PET/CT and biopsy...
January 31, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29398473/daily-step-count-as-a-simple-marker-of-disease-severity-in-hypertrophic-cardiomyopathy
#6
Joanna Sweeting, Jodie Ingles, Kylie Ball, Christopher Semsarian
BACKGROUND: Individuals with hypertrophic cardiomyopathy (HCM) may be asymptomatic or display activity-limiting symptoms. A common cause of symptoms is left ventricular outflow tract obstruction (LVOTO), which may impact the individuals' ability to undertake physical activity. This study sought to examine daily step count as a potential marker of exercise capacity, which may represent a proxy marker of disease severity in HCM. METHODS: A cross-sectional study of 63 HCM patients was conducted from March to November 2015...
January 31, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29398471/tuberculous-aortitis-associated-with-pleuritis-and-spondylitis
#7
Ya-Chun Hsu, Chwan-Yau Luo, Yi-Shan Tsai
No abstract text is available yet for this article.
January 31, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29402690/outcomes-of-heart-block-in-myocarditis-a-review-of-31-760-patients
#8
Gbolahan O Ogunbayo, Samy-Claude Elayi, Le Dung Ha, Odunayo Olorunfemi, Ayman Elbadawi, Deola Saheed, Vincent L Sorrell
BACKGROUND: Various electrocardiographic abnormalities, including atrioventricular conduction block, have been reported in patients with myocarditis. We performed an observation study to describe the characteristics and outcomes of inpatients diagnosed with myocarditis complicated by heart block (HB) in a large national cohort. METHODS: We identified patients with primary ICD-9 codes for myocarditis HB from the Nationwide Inpatient Survey (NIS) Database from 1998 to 2013...
December 24, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29402693/left-atrial-appendage-exclusion-using-the-atriclip-device-a-case-series
#9
Sarah Page, Jane Hallam, Neelprada Pradhan, Brian Cowie, Tuong Phan, Desmond McGlade, Alex Rosalion, Andrew Newcomb, Michael Yii
BACKGROUND: Atrial fibrillation (AF) affects 1.5-2% of the population and is associated with a five-fold increased lifetime risk of stroke [1]. The left atrial appendage (LAA) is the source of embolic strokes in up to 90% of patients with non-valvular AF with clots in the left atrium [2]. METHODS: We reviewed the clinical notes and echocardiographic findings of 20 patients who underwent open cardiac surgery in which concurrent AtriClip (Atricure Inc, Westchester, Ohio, USA) device insertion was attempted at our institution from July 2013 to February 2015...
December 22, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29402692/life-after-surviving-fontan-surgery-a-meta-analysis-of-the-incidence-and-predictors-of-late-death
#10
REVIEW
C L Poh, Y d'Udekem
AIM: We now know that 20-40% of patients with a single ventricle will develop heart failure after the second decade post-Fontan surgery. However, we remain unable to risk-stratify the cohort to identify patients at highest risk of late failure and death. We conducted a systematic review of all reported late outcomes for patients with a Fontan circulation to identify predictors of late death. METHODS: We searched MEDLINE, Embase and PubMed with subject terms ("single ventricle", "Hypoplastic left heart syndrome", "congenital heart defects" or "Fontan procedure") AND ("heart failure", "post-operative complications", "death", "cause of death", "transplantation" or "follow-up studies") for relevant studies between January 1990 and December 2015...
December 20, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29409723/camkii-in-vascular-signalling-friend-or-foe
#11
REVIEW
Obialunanma V Ebenebe, Alison Heather, Jeffrey R Erickson
Signalling mechanisms within and between cells of the vasculature enable function and maintain homeostasis. However, a number of these mechanisms also contribute to the pathophysiology of vascular disease states. The multifunctional signalling molecule calcium/calmodulin-dependent kinase II (CaMKII) has been shown to have critical functional effects in many tissue types. For example, CaMKII is known to have a dual role in cardiac physiology and pathology. The function of CaMKII within the vasculature is incompletely understood, but emerging evidence points to potential physiological and pathological roles...
December 19, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29277546/inhibition-of-apoptosis-signal-regulating-kinase-1-attenuates-myocyte-hypertrophy-and-fibroblast-collagen-synthesis
#12
Wendi Yang, Bing Hui Wang, Ian Wang, Li Huang, Feby Savira, Andrew Kompa, Beat M Jucker, Robert N Willette, Darren Kelly, Henry Krum, Zhiliang Li, Qian Fu
BACKGROUND: Cardiac remodelling is a dynamic process whereby structural and functional changes occur within the heart in response to injury or inflammation. Recent studies have demonstrated reactive oxygen species sensitive MAPK, apoptosis signal-regulating kinase 1 (ASK1) plays a critical role in cardiac remodelling. This study aims to determine the effectiveness of small molecule ASK1 inhibitors on these processes and their therapeutic potential. METHODS: Neonatal rat cardiac fibroblasts (NCF) were pre-treated with ASK1 inhibitors, G2261818A (G226) and G2358939A (G235), for 2hours before stimulated with 100nM angiotensin II (AngII), 10μM indoxyl sulphate (IS) or 10ng/ml transforming growth factor β1 (TGFβ1) for 48hours...
December 14, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29276147/evaluation-of-cobalt-and-chromium-levels-following-implantation-of-cobalt-chromium-coronary-stents-a-pilot-study
#13
Pietro Di Santo, Pouya Motazedian, Richard G Jung, Trevor Simard, F Daniel Ramirez, Aun-Yeong Chong, Christopher Glover, Benjamin Hibbert, Girish Dwivedi
BACKGROUND: Large increases in myocardial trace elements may adversely affect metabolism and become detrimental to cardiac function. Percutaneous coronary intervention (PCI) allows for the revascularisation of obstructive coronary artery disease using drug-eluting stents. These stents are comprised of a metallic stent backbone covered in an engineered polymer which delivers a drug over a prescribed period to the vessel wall. Given the potential implications of trace metal accumulation within the myocardium, our goal is to determine if metallic coronary stents are able to cause detectable elevations in serum cobalt and/or chromium levels...
December 14, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29277547/recurrent-bioprosthetic-valve-thrombosis-should-long-term-anticoagulation-be-considered
#14
Matthew S Yong, Robert Grant, Pankaj Saxena, Sumit Yadav
Bioprosthetic valve thrombosis (BPVT) is an important and potentially reversible cause of valvular dysfunction. This complication can occur many years after surgery and understanding of the precise mechanisms and risk factors are limited. Anticoagulation therapy has been demonstrated to be effective in improving BPVT. However, the optimal duration of therapy and the risk of recurrence are unknown. Herein, we describe two cases-one of late BPVT and one of recurrence of BPVT after cessation of anticoagulation therapy...
December 11, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29291961/minimally-invasive-aortic-valve-replacement-via-right-anterior-mini-thoracotomy-propensity-matched-initial-experience
#15
Michael Seitz, Joshua Goldblatt, Eldho Paul, Thomas Marcus, Marco Larobina, Cheng-Hon Yap
BACKGROUND: Aortic valve replacement by way of a right anterior mini-thoracotomy (RAMT) has shown excellent results in terms of mortality and morbidity. The aim of the present study was to compare RAMT aortic valve replacement (AVR) with conventional full sternotomy in regards to early perioperative outcomes and mortality. METHODS: This was a retrospective, observational, cohort study of prospectively collected data from patients who underwent isolated, first time AVR between January 2013 and October 2016...
December 7, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29277548/outcomes-of-video-assisted-minimally-invasive-cardiac-myxoma-resection
#16
Giacomo Bianchi, Rafik Margaryan, Enkel Kallushi, Alfredo Giuseppe Cerillo, Pier Andrea Farneti, Angela Pucci, Marco Solinas
BACKGROUND: Myxomas are the most frequent cardiac tumours. Their diagnosis requires prompt removal. In our centre, for valve surgery we use a minimally invasive approach. Here, we report our experience of cardiac myxoma removal through right lateral mini-thoracotomy (RLMT) with particular focus on its feasibility, efficacy and patient safety. METHODS: Between February 2006 and January 2017, 30 consecutive patients (aged 66±12.6years, range 35-83 years) underwent atrial myxoma resection through video-assisted RLMT...
December 7, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29246681/a-flowmeter-technique-to-exclude-internal-mammary-artery-anastomosis-error-in-an-arrested-heart
#17
Shahrul A Hashim, Mohd Afiq Amin, Ashvin Nair, Raja Amin Raja Mokhtar, Sivakumar Krishnasamy, Kenny Cheng
The revision of an internal mammary artery graft anastomosis because of a technical error can be time consuming and complicated and may lead to complications. Here, we describe the technical details and our early experience of using a standard transit-time flowmeter to exclude technical errors and facilitate rapid decision making for anastomosis revision in an arrested heart during aortic cross-clamping in the absence of ultrasound guidance.
December 7, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29337086/incidental-pulmonary-nodules-are-common-on-ct-coronary-angiogram-and-have-a-significant-cost-impact
#18
James Robertson, Sandra Nicholls, Philip Bardin, Ronnie Ptasznik, Daniel Steinfort, Alistair Miller
BACKGROUND: Computed tomography (CT) coronary angiogram (CTCA) is commonly used for diagnostic evaluation of low-moderate risk patients due to its excellent performance and cost-effectiveness. However, previous cost analyses have not factored in the burden of management of pulmonary nodules, which are a common occurrence. We sought to describe the frequency and characteristics of lung nodules on CTCA in an Australian tertiary hospital, and to assess cost impacts. METHODS: Consecutive CTCAs performed in the calendar year 2012 were retrospectively identified from the imaging department database...
December 5, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29246680/early-outcomes-after-mitral-valve-repair-vs-replacement-in-the-elderly-a-propensity-matched-analysis
#19
Shakil Farid, Andrew Ladwiniec, Jules Hernández-Sánchez, Hannah Povey, Edward Caruana, Ayyaz Ali, Narain Moorjani, Joanne Irons, Liam Ring, Yasir Abu-Omar
BACKGROUND: To compare early outcomes of mitral valve repair versus replacement in elderly patients with degenerative mitral valve disease. METHODS: A retrospective review of prospectively collected clinical data of patients over 75 years of age, who underwent mitral valve surgery for degenerative disease, between 2010 and 2013, was carried out. Those undergoing mitral valve repair and replacement were propensity matched to adjust for baseline clinical differences...
December 5, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29233497/early-and-late-survival-of-on-pump-cardiac-surgery-patients-formerly-affected-by-lymphoma
#20
Giuseppe Gatti, Oscar Maraldo, Bernardo Benussi, Rossana Bussani, Gianluca Castaldi, Gianfranco Sinagra, Aniello Pappalardo
BACKGROUND: Survival after cardiac surgery of patients formerly affected by lymphoma has not been well defined. METHODS: Forty-five consecutive patients having prior Hodgkin's (HL patients, n=26) or non-Hodgkin's lymphoma (non-HL patients, n=19) underwent on-pump cardiac surgery at the authors' institution (2001-2016). Ischaemic, valvular, and ischaemic plus valvular heart disease were present in 14, 13, and 18 patients, respectively. Concomitant aortic disease was treated in three cases...
November 28, 2017: Heart, Lung & Circulation
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