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Heart, Lung & Circulation

Wei Li, Jian Sun, Ying Yu, Zhi-Quan Wang, Peng-Pai Zhang, Kai Guo, Man-Tian Chen, Yi-Gang Li
BACKGROUND: Post cardiac injury syndrome (PCIS) is a troublesome but not uncommon complication following catheter ablation of arrhythmias. We aimed to study the clinical features of ablation-associated PCIS. METHODS: For this purpose, we conducted a computerised literature search that identified 19 published cases, and we additionally included another 2 new cases from our centres. Twenty-one cases of PCIS following ablation were analysed. RESULTS: Among the 21 cases, PCIS most commonly occurred after atrial flutter/fibrillation (AFL/AF) ablation (71...
October 7, 2018: Heart, Lung & Circulation
Yan Jin, Tian-Yi Zhou, Jia-Ning Cao, Qiu-Ting Feng, Ya-Jing Fu, Xin Xu, Cheng-Jian Yang
BACKGROUND: MicroRNAs (miRNAs) are critical modulators of various physiological and pathological processes, but their role in cardiac arrhythmias remains yet to be completely understood. Connexin43 (Cx43) is an important cardiac gap junction protein and a potential target of miR-206, and downregulation of Cx43 induces ventricular tachyarrhythmias. METHODS: We investigated the effects of miR-206 overexpression on the adult mouse heart and in cardiac arrhythmias. Luciferase activity assay was employed to validate Cx43 as a direct target of miR-206...
October 4, 2018: Heart, Lung & Circulation
Adam Lee, Tomos E Walters, Edward P Gerstenfeld, Haris M Haqqani
Frequent ventricular ectopy is a common clinical presentation in patients suffering idiopathic ventricular outflow tract arrhythmias. These are focal arrhythmias that generally occur in patients without structural heart disease and share a predilection for characteristic anatomic sites of origin. Mechanistically, they are generally due to cyclic adenosine monophosphate (cAMP)-mediated triggered activity. As a result, there is typically an exercise or catecholamine related mode of induction and often a sensitivity to suppression with adenosine...
October 4, 2018: Heart, Lung & Circulation
Giuseppe Femia, Christopher Semsarian, Neil Langlois, Mark McGuire, James Raleigh, Andrew Taylor, Rajesh Puranik
Sudden cardiac death (SCD) is a catastrophic complication of many cardiac conditions often occurring without warning. In these cases, a post-mortem examination is required to elucidate the cause of death and is regarded as the 'gold standard'. However, in circumstances of certain religious/cultural beliefs and advanced body decomposition an alternative non-invasive approach would be preferred. Although a developing field, post-mortem imaging using computed tomography (pmCT) or magnetic resonance imaging (pmMR) provides a non-invasive and accurate alternative to traditional post-mortem in specific circumstances...
September 29, 2018: Heart, Lung & Circulation
Miha Tibaut, Martin Caprnda, Peter Kubatka, Andreja Sinkovič, Vanda Valentova, Slavomira Filipova, Katarina Gazdikova, Ludovit Gaspar, Ioana Mozos, Emmanuel E Egom, Luis Rodrigo, Peter Kruzliak, Daniel Petrovič
This is Part 2 of a two-part review summarising current knowledge on biomarkers of atherosclerosis. Part 1 addressed serological biomarkers. Here, in part 2 we address genetic and imaging markers, and other developments in predicting risk. Further improvements in risk stratification are expected with the addition of genetic risk scores. In addition to single nucleotide polymorphisms (SNPs), recent advances in epigenetics offer DNA methylation profiles, histone chemical modifications, and micro-RNAs as other promising indicators of atherosclerosis...
September 29, 2018: Heart, Lung & Circulation
Hao Liu, Ju Mei, Yi He, Zhaolei Jiang, Min Tang
Epicardial surgical repair has been proven to be effective for patients with coronary- pulmonary artery fistula (CPAF). However, most of the surgery has been performed through a median sternotomy under cardiopulmonary bypass. In this report, we describe a novel technique of performing minimally invasive surgery for CPAF patients without extracorporeal circulation via a parasternal minithoracotomy. This technique has proved to be safe and effective and may be worthy of use for patients with CPAF.
September 29, 2018: Heart, Lung & Circulation
Robert D Anderson, Saurabh Kumar, Jonathan M Kalman, Prashanthan Sanders, Frederic Sacher, Meleze Hocini, Pierre Jais, Michel Haisaguerre, Geoffrey Lee
Ventricular fibrillation (VF) is a common and life-threatening arrhythmia resulting in sudden cardiac death (SCD). Due to the inherent challenges of mapping VF in humans, the underlying mechanisms that initiate and sustain this common arrhythmia are still poorly understood. In high-risk patients and survivors of SCD, implantable cardioverter defibrillators (ICD) play a central role in treating VF episodes, however, ICDs do not prevent VF recurrences and patients remain at risk of electrical storm and multiple shocks that are often refractory to escalation of medical therapy...
September 29, 2018: Heart, Lung & Circulation
Niraj N Pandey, Arun Sharma, Sanjeev Kumar
No abstract text is available yet for this article.
September 29, 2018: Heart, Lung & Circulation
Navneet Singh, Damian Gimpel, Grant Parkinson, Paul Conaglen, Felicity Meikle, Zaw Lin, Nand Kejriwal, Nicholas Odom, David J McCormack, Adam El-Gamel
BACKGROUND: The updated European System for Cardiac Operative Risk Evaluation (EuroSCORE II) is a well-established cardiac surgery risk scoring tool for estimating operative mortality. This risk stratification system was derived from a predominantly European patient cohort. No validation analysis of this risk model has been undertaken for the New Zealand population across all major cardiac surgery procedures. We aim to assess the efficacy (discrimination and calibration) of the EuroSCORE II for predicting mortality in cardiac surgical patients at a large New Zealand tertiary centre...
September 27, 2018: Heart, Lung & Circulation
Michaël Peyrol, Jennifer Cautela, Erwan Salaun, Charlène Miola, Frederic Franceschi, Franck Thuny, Johan Pinto, Marc Laine, Alexandre Maximovitch, Franck Paganelli, Sébastien Armero, Laurent Bonello
BACKGROUND: Left atrial appendage occlusion (LAAO) is increasingly used for stroke prevention in patients with atrial fibrillation who are considered unsuitable for a lifelong oral anticoagulant regimen. Recently, a single-centre study reported device-related thrombus formation in 16.7% of patients treated with the second-generation Amulet device (St. Jude Medical, St. Paul, MN, USA), presenting a potential major safety concern. As "real-world" data on device-related thrombus formation following LAAO with the Amulet occluder are scarce, we aimed to evaluate this outcome in a retrospective registry...
September 27, 2018: Heart, Lung & Circulation
Hui Wang, Qian Wang, Zhuang Tian, Xiaoxiao Guo, Jinzhi Lai, Mengtao Li, Jiuliang Zhao, Yongtai Liu, Xiaofeng Zeng, Quan Fang
BACKGROUND: Right ventricular (RV) function has been identified as an important determinant of outcome in patients with pulmonary hypertension. We aimed to investigate the relationship between echocardiographic-derived RV function and health-related quality of life (HRQOL) in patients with systemic lupus erythematosus associated pulmonary arterial hypertension (SLE-APAH), and to identify the best echocardiographic parameter for evaluating RV function in these patients. METHODS: Sixty consecutive patients with SLE-APAH (all female, mean age 33...
September 27, 2018: Heart, Lung & Circulation
John H Farnsworth, Bronwyn M Krieg, Jayme S Bennetts, Robert A Baker
BACKGROUND: The cost of performing cardiac surgery in the public health system in Australia is unclear. This paper analyses the cost of cardiac surgery performed at Flinders Medical Centre (FMC), South Australia, comparing cost by procedure, rheumatic valvular heart disease status, Aboriginality and location. METHODS: This study is a retrospective, population-based analysis of cardiac surgery data held in the Cardiac Surgery Registry cross-referenced to cost data provided by the FMC Department of Finance and Patient Travel, Accommodation and Transport Services at the Royal Darwin Hospital...
September 24, 2018: Heart, Lung & Circulation
Haris M Haqqani, Francis E Marchlinski
The 12-lead electrocardiograph (ECG) is of critical importance both in the diagnosis of wide complex tachycardia and in the further classification, characterisation and management of ventricular arrhythmias. With its diligent application and interpretation, remarkable precision can be achieved in the localisation of the site of origin of ventricular arrhythmias and this may have major implications in the care of these patients. This review discusses the technical, anatomic and mechanistic basis of ECG interpretation in ventricular arrhythmias...
September 24, 2018: Heart, Lung & Circulation
Yi-Peng Ge, Cheng-Nan Li, Li-Jian Cheng, Tie Zheng, Jun Zheng, Yong-Min Liu, Jun-Ming Zhu, Li-Zhong Sun
BACKGROUND: To evaluate one-stage repair with ascending to abdominal aorta extra-anatomical bypass combined with cardiac surgery for adult aortic coarctation (COA) concomitant with cardiac diseases. METHODS: Between February 2009 and September 2016, 24 consecutive patients (79.17% male, mean age 36.04±13.67years) with COA and concomitant cardiac diseases underwent one-stage repair (ascending to abdominal aorta extra-anatomical bypass combined with cardiac surgery)...
September 22, 2018: Heart, Lung & Circulation
Alberto Jorge Alves, Norton Luís Oliveira, Susana Lopes, Maria-Arantzazu Ruescas-Nicolau, Madalena Teixeira, José Oliveira, Fernando Ribeiro
BACKGROUND: Augmented arterial stiffness and reduced cardiorespiratory fitness are associated with increased morbidity and mortality from coronary artery disease (CAD). The relationship between exercise capacity and arterial stiffness is independent of known influencing variables in CAD. This study aimed to analyse the interaction between exercise capacity, arterial stiffness and early vascular ageing in patients with CAD. METHODS: This cross-sectional study included 96 CAD patients with myocardial infarction (55...
September 19, 2018: Heart, Lung & Circulation
India Zweng, Sean Galvin, Ray Robbins, Rinaldo Bellomo, Graeme K Hart, Siven Seevanayagam, George Matalanis
BACKGROUND: 3-factor prothrombin complex concentrate (3F-PCC) may provide a valuable treatment option for coagulopathy in cardiac surgery patients. However, it may expose patients to increased risk of thromboembolic events. Accordingly, we compared the incidence of thromboembolic events between patients exposed to 3F-PCC and those receiving conventional therapy. METHODS: Demographic, operative and postoperative data was obtained in a cohort of consecutive patients exposed to 3F-PCC and a contemporaneous control population...
September 14, 2018: Heart, Lung & Circulation
En-Kuei Tang, Chi-Shen Chen, Carol C Wu, Ming-Ting Wu, Tseng-Lung Yang, Huei-Lung Liang, Hui-Ting Hsu, Fu-Zong Wu
BACKGROUND: The long-term natural course and outcomes of subsolid nodules (SSNs) in terms of true growth, substantial growth, and stage shift need to be clarified. METHODS: Between 2002 and 2016, 128 subjects with persistent SSNs of 3cm or smaller were enrolled. The baseline and interval changes in the series computed tomography (CT) findings during the follow-up period were subsequently reviewed. RESULTS: The mean follow-up period was 3.57±2...
September 14, 2018: Heart, Lung & Circulation
Suresh Babu Kale, Senthilkumar Ramalingam
BACKGROUND: A minimally invasive approach without any peripheral cannulation was used as an alternative to median sternotomy for the correction of a wide range of cardiac defects with superior results and good cosmetic outcome. METHODS: From October 2015 to March 2017, 145 patients underwent correction of congenital cardiac malformations with cardiopulmonary bypass through right anterior minithoracotomy (RAMT) with routine cannulation. The average age was 9.69±4...
September 12, 2018: Heart, Lung & Circulation
Yeliz Erol, Ayşe Gül Ergönül, Ali Özdil, Sanem Nalbantgil, Ufuk Çağırıcı, Kutsal Turhan, Alpaslan Çakan
BACKGROUND: Patients who underwent lung resection in our clinic were retrospectively investigated in terms of development of postoperative cardiac complications. METHODS: The file records of 207 patients who underwent lung resection between the years 2010 and 2014 were reviewed. One hundred and eighteeen (57%) of the patients were evaluated by the preoperative cardiologist and the risk level of the patients was determined according to the Lee index. Postoperative cardiac complication relation was compared with each parameter...
September 12, 2018: Heart, Lung & Circulation
M L Gazzana, J J Souza, M P Okoshi, K Okoshi
BACKGROUND: Pulmonary arterial hypertension (PAH) occurs in 35% to 65% of hyperthyroid patients. Despite this high frequency, only a few authors have examined the effects of hyperthyroidism treatment on PAH and the right ventricle. We evaluated the effects of hyperthyroidism and its reversal on cardiovascular structure and function using Doppler echocardiography. METHODS: We prospectively evaluated 32 patients (42.5±11.9years old) with thyrotoxicosis. Exclusion criteria included previous cardiovascular disease...
September 12, 2018: Heart, Lung & Circulation
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