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Heart, Lung & Circulation

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https://www.readbyqxmd.com/read/28087153/lipoprotein-subfractions-in-type-2-diabetes
#1
EDITORIAL
Leonardo Roever, Elmiro Santos Resende, Joseph S Alpert
No abstract text is available yet for this article.
December 23, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28094123/myocardial-and-serum-galectin-3-expression-dynamics-marks-post-myocardial-infarction-cardiac-remodelling
#2
Umesh C Sharma, Wassim Mosleh, Milind R Chaudhari, Rujuta Katkar, Brian Weil, Chris Evelo, Thomas R Cimato, Saraswati Pokharel, W Matthijs Blankesteijn, Gen Suzuki
BACKGROUND: Acute myocardial infarction (MI) causes significant changes in cardiac morphology and function. Galectin-3 is a novel and potentially therapeutically important mediator of cardiac remodelling. Myocardial and serum galectin-3 expression dynamics in response to the early cardiovascular outcomes after acute MI are not fully elucidated. METHODS: We first performed a comprehensive longitudinal microarray analyses in mice after acute MI. We then measured the serum levels of galectin-3 in a translational porcine model of coronary microembolism-induced post-ischaemic cardiac remodelling...
December 19, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28094122/cardiac-remote-ischaemic-preconditioning-mechanistic-and-clinical-considerations
#3
REVIEW
Jerrett K Lau, Gabrielle J Pennings, Andy Yong, Leonard Kritharides
Brief, non-harmful ischaemic insults to an organ remote from the heart, remote ischaemic preconditioning (RIPC), has been proposed to confer protection to the heart against ischaemia-reperfusion injury. While most clinical trials of RIPC during coronary interventions (PCI) suggest benefit, recent large, multicentre trials in coronary artery bypass surgery suggest a lack of efficacy. Mechanistically, RIPC most likely promotes the release of circulating factors which modulate multiple cellular pathways in the heart, promoting cell survival...
December 12, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28087154/evaluation-of-serial-high-sensitivity-troponin-t-levels-in-individuals-without-overt-coronary-heart-disease-following-exercise-stress-testing
#4
Yousef M E Saad, Hanan Idris, Ibrahim M Shugman, Krishna K Kadappu, Rohan Rajaratnam, Liza Thomas, Christian Mussap, Dominic Y C Leung, Craig P Juergens, John K French
BACKGROUND: Detectable levels of high sensitivity (cardiac) troponin T (HsTnT), occur in the majority of patients with stable coronary heart disease (CHD), and often in 'healthy' individuals. Extreme physical activity may lead to marked elevations in creatine kinase MB and TnT levels. However, whether HsTnT elevations occur commonly after exercise stress testing (EST), and if so, whether this has clinical significance, needs clarification. METHODS: To determine whether HsTnT levels become elevated after EST (Bruce protocol) to ≥95% of predicted maximum heart rate in presumed healthy subjects without overt CHD, we assayed HsTnT levels for ∼5h post-EST in 105 subjects (median age 37 years)...
December 9, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28027866/analysis-of-lipoprotein-subfractions-in-920-patients-with-and-without-type-2-diabetes
#5
Xi Zhao, Hui-Wen Zhang, Yan Zhang, Sha Li, Rui-Xia Xu, Jing Sun, Cheng-Gang Zhu, Na-Qiong Wu, Ying Gao, Yuan-Lin Guo, Geng Liu, Qian Dong, Jian-Jun Li
BACKGROUND: It has been demonstrated that diabetic dyslipidaemia is the chief bridge between diabetes and incremental risk of cardiovascular disease in patients with diabetes. However, the characteristics of lipoprotein subfractions distribution in patients with type 2 diabetes (T2D) have not been fully investigated. The aim of present study was to evaluate the distributions of lipoprotein subfractions in T2D patients. METHODS: A total of 920 patients, who have not received lipid-lowering drug treatment previously, were consecutively enrolled in this study...
December 9, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28034709/transcatheter-closure-of-perimembranous-ventricular-septal-defects-using-dual-wire-maintaining-technique
#6
Xu-Dong Xu, Li-Ming Gao, Yuan Bai, Zhi-Gang Zhang, Xiao-Hua You, Xian-Xian Zhao, Yong-Wen Qin
OBJECTIVE: The present study was designed to evaluate the safety and feasibility of transcatheter closure of perimembranous ventricular septal defects (PmVSDs) with dual wire-maintaining technique (DWMT). PATIENTS/METHODS: From January 2010 to December 2013, a total of 241 patients (men: 109, women: 132; mean age: 22.2±15.4 years) with congenital PmVSDs were randomised to either the conventional technique (CT) group (n=118) or the DWMT group (n=123). RESULTS: In the CT group, the track wire was withdrawn before occluder insertion...
December 7, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28034708/influence-of-age-and-gender-on-clinical-outcomes-following-percutaneous-coronary-intervention-for-acute-coronary-syndromes
#7
Hanan Idris, John K French, Ibrahim M Shugman, Andrew P Hopkins, Craig P Juergens, Liza Thomas
BACKGROUND: Gender and age are non-modifiable factors influencing clinical outcomes in acute coronary syndromes (ACS). There is evidence that coronary artery disease pathophysiology varies in women. We therefore evaluated the effect of age and gender on clinical outcomes in patients with ACS undergoing percutaneous coronary interventions (PCI). METHODS: Among 3178 (25% female) consecutive ACS patients who underwent PCI at Liverpool Hospital, Sydney from 2003 to 2010, using femoral access in 98% of cases, we determined late events including mortality, myocardial infarction and bleeding according to Bleeding Academic Research Consortium (BARC) criteria...
December 2, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27989690/comparing-the-efficacy-of-tadalafil-versus-placebo-on-pulmonary-artery-systolic-pressure-and-right-ventricular-function-in-patients-with-beta-thalassaemia-intermedia
#8
Rozita Jalalian, Ali Akbar Moghadamnia, Ahmad Tamaddoni, Soraya Khafri, Mohammadreza Iranian
BACKGROUND: Conventional oral therapies in the management of pulmonary hypertension in people without haemoglobinopathies are of limited value in thalassaemia patients because of toxicity and poor effectiveness. This study was conducted to assess the effect of tadalafil on pulmonary artery pressure and right ventricular systolic function in patients with beta-thalassaemia intermedia. METHODS: Forty-four patients with beta-thalassaemia intermedia with pulmonary hypertension based on transthoracic echocardiography (TTE) were entered in the study...
December 2, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27988277/the-new-zealand-norwood-procedure-experience-22-year-cumulative-review
#9
Timothy Ht Oh, John H Artrip, Chris Graddon, Cliodhna Minogue, Luciana Marcondes, Kirsten Finucane, Thomas Gentles
BACKGROUND: Babies born with a functional single ventricle heart and systemic outflow tract obstruction may require a Norwood (NW) procedure as the first of three staged procedures to obtain a Fontan circulation. This procedure and the following treatment pathway are associated with significant mortality. Risk factors for the Norwood procedure and the subsequent pathway are not necessarily the same. To identify these factors within New Zealand, the collective experience with the Norwood procedure was examined...
December 2, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28089788/cardiovascular-disease-risk-assessment-in-australian-community-pharmacy
#10
Kevin P Mc Namara, Gregory M Peterson, Josie Hughes, Ines Krass, Vincent Versace, Robyn A Clark, James Dunbar
BACKGROUND: Population screening and monitoring of cardiovascular risk is suboptimal in Australian primary care. The role of community pharmacy has increased considerably, but without any policy framework for development. The aim of this study was to explore the nature of community pharmacy-based screening models in Australia, capacity to increase delivery of pharmacy screening, and barriers and enablers to increasing capacity. METHODS: An online survey weblink was emailed to pharmacy managers at every quality-accredited pharmacy in Australia by the Quality Pharmacy Care Program...
November 30, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28065523/a-web-based-registry-for-familial-hypercholesterolaemia
#11
Kathryn R Napier, Jing Pang, Leanne Lamont, Caroline E Walker, Hugh Js Dawkins, Adam A Hunter, Frank M van Bockxmeer, Gerald F Watts, Matthew I Bellgard
Familial hypercholesterolaemia (FH) is the most common and serious monogenic disorder of lipoprotein metabolism that leads to premature coronary heart disease. Patients with FH are often under-treated, and many remain undiagnosed. The deployment of the FH Australasia Network Registry is a crucial component of the comprehensive model of care for FH, which aims to provide a standardised, high-quality and cost-effective system of care that is likely to have the highest impact on patient outcomes. The FH Australasia Network Registry was customised using a registry framework that is an open source, interoperable system that enables the efficient customisation and deployment of national and international web-based disease registries that can be modified dynamically as registry requirements evolve...
November 30, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27993487/the-use-of-telehealth-to-reduce-inequalities-in-cardiovascular-outcomes-in-australia-and-new-zealand-a-critical-review
#12
REVIEW
Victoria Wade, Nigel Stocks
Telehealth, the delivery of health care services at a distance using information and communications technology, is one means of redressing inequalities in cardiovascular outcomes for disadvantaged groups in Australia. This critical review argues that there is sufficient evidence to move to larger-scale implementation of telehealth for acute cardiac, acute stroke, and cardiac rehabilitation services. For cardiovascular chronic disease and risk factor management, telehealth-based services can deliver value but the evidence is less compelling, as the outcomes of these programs are variable and depend upon the context of their implementation...
November 30, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27989691/aquatic-exercise-training-is-effective-in-maintaining-exercise-performance-in-trained-heart-failure-patients-a-randomised-crossover-pilot-trial
#13
Julie Adsett, Norman Morris, Suzanne Kuys, Rita Hwang, Robert Mullins, Mohsina Khatun, Jennifer Paratz, Alison Mudge
BACKGROUND: Providing flexible models and a variety of exercise options are fundamental to supporting long-term exercise participation for patients with heart failure (HF). The aim of this pilot study was to determine the feasibility and efficacy of aquatic exercise training during a maintenance phase for a clinical heart failure population. METHODS: In this 2 x 2 crossover design trial, individuals who had previously completed HF rehabilitation were randomised into either a land-based or aquatic training program once per week for six weeks, after which time they changed to the alternate exercise training protocol for an additional six weeks...
November 30, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27988281/distribution-of-abo-blood-groups-and-coronary-artery-calcium
#14
Yao Wang, Bing-Yang Zhou, Cheng-Gang Zhu, Yuan-Lin Guo, Na-Qiong Wu, Ping Qing, Ying Gao, Geng Liu, Qian Dong, Jian-Jun Li
BACKGROUND: ABO blood groups have been confirmed to be associated with cardiovascular diseases such as coronary artery disease. However, whether ABO blood group is correlated with coronary artery calcium (CAC) is still unknown. METHOD: 301 patients with coronary artery calcium score (CACS) assessed by computed tomography were consecutively enrolled and divided into two groups: with calcium group (CACS>0, n=104) and without calcium group (CACS=0, n=197). Distribution of ABO blood groups was evaluated between the two groups...
November 30, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27988278/right-ventricular-response-during-exercise-in-patients-with-chronic-obstructive-pulmonary-disease
#15
Diego A Rodríguez, Antonio Sancho-Muñoz, Anna Rodó-Pin, Anna Herranz, Joaquim Gea, Jordi Bruguera, Lluis Molina
AIM: Right ventricular (RV) pump function is of essential clinical and prognostic importance in a variety of heart and lung diseases. While the evaluation of RV performance at rest has been implemented in the clinical setting, it is unknown whether this assessment during exercise may provide additional benefit. With this aim, we evaluated the exercise-induced pulmonary arterial systolic pressure (PASP) increase during exercise in patients with severe chronic obstructive pulmonary disease (COPD) as an expression of RV contractile reserve...
November 30, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28089790/shirtfront-myocardial-infarction-traumatic-coronary-plaque-disruption-secondary-to-a-football-tackle
#16
LETTER
Ryan Markham, Dale Murdoch, Jayamanee Govindasamy, Christopher Raffel, Darren Walters
No abstract text is available yet for this article.
November 24, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27956161/prolonged-cardiopulmonary-bypass-is-a-risk-factor-for-intestinal-ischaemic-damage-and-endotoxaemia
#17
Barbara Adamik, Andrzej Kübler, Anna Gozdzik, Waldemar Gozdzik
BACKGROUND: Intestinal ischaemia-reperfusion, a frequent occurrence during cardiac surgery with cardiopulmonary bypass (CPB) induces a systemic inflammatory reaction. We hypothesised that ischaemia-reperfusion following prolonged CPB could increase intestinal permeability and thus, lead to endotoxin translocation from the intestine to the bloodstream. MATERIAL AND METHODS: Patients subjected to coronary artery bypass grafting with CPB were included: Group 1 (CPB ≥90minutes) or Group 2 (CPB <90minutes)...
November 24, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27956160/microrna-145-mediates-the-formation-of-angiotensin-ii-induced-murine-abdominal-aortic-aneurysm
#18
Jing Wu, Jun Wang, Xiaoou Li, Xiaofeng Liu, Xiuyan Yu, Yunling Tian
BACKGROUND: MicroRNA-145 (miR-145) has been implicated in vascular smooth muscle cell differentiation, but the underlying mechanisms have not been fully understood, especially their role in abdominal aortic aneurysm (AAA) expansion. Here, we sought to explore and define the mechanisms of miR-145 function in the experimental AAA models in AngII-infused ApoE(-/-) mice. METHODS: miR-145 was overexpressed in ApoE(-/-) mice via lentivirus infection, and then the incidence of AAA, maximum abdominal aortic diameter, elastin degradation and MMP2 activation were determined in AngII-infused ApoE(-/-) mice...
November 24, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27939745/the-effect-of-left-ventricular-assist-device-implantation-on-serum-albumin-total-protein-and-body-mass-a-short-term-longitudinal-follow-up-study
#19
Tolga Sinan Guvenc, Ozge Güzelburc, Ahmet Ekmekci, Sevinc Bayer Erdogan, Rengin Cetin Guvenc, Yalcin Velibey, Muge Tasdemir, Semra Agustos, Gokcen Orhan, Serap Aykut Aka, Mehmet Eren
BACKGROUND: Cardiac cachexia and low serum albumin levels are poor prognostic signs in advanced heart failure, while overweight patients or patients who gain weight after treatment have more favourable outcomes. Weight gain following LVAD implantation is common, while the dynamic changes in body mass or serum proteins have not been studied adequately. Our aim was to study short-term changes in serum albumin, total protein and body weight following LVAD implantation and to compare these changes with heart failure patients treated medically...
November 24, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27988280/comparison-of-efficacy-pattern-of-response-occurrence-of-arrhythmias-and-the-tolerability-of-nitroglycerine-and-isoprenaline-as-provocative-drugs-during-head-up-tilt-test
#20
Mukund Aravind Prabhu, Vivek Pillai, Jayaprakash Shenthar
BACKGROUND: Various protocols exist for performing head-up tilt test (HUTT). Serious ventricular arrhythmias have been reported during HUTT using Isoprenaline (ISO) provocation and their incidence with sublingual Nitroglycerine provocation is unknown. This study aims to assess the efficacy, pattern of response, tolerability, and frequency of arrhythmias during head-up tilt test with sublingual Nitroglycerine (NTG) provocation compared to ISO) provocation. METHODS: This is a retrospective observational study...
November 23, 2016: Heart, Lung & Circulation
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