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Heart, Lung & Circulation

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https://www.readbyqxmd.com/read/27889294/increasing-the-detection-of-fh-using-general-practice-electronic-databases
#1
Alistair W Vickery, Jackie Ryan, Jing Pang, Jacquie Garton-Smith, Gerald F Watts
BACKGROUND: Familial hypercholesterolaemia (FH) is a common autosomal co-dominant condition that causes premature cardiovascular disease. Awareness of FH is poor and only 10-15% of the affected population is identified. Electronic health records provide an opportunity to increase detection and awareness in general practice OBJECTIVE: To determine whether a simple electronic extraction tool can increase detection of FH in general practice. METHOD: An extraction tool applied to general practice electronic health records (EHR) to screen for FH, total cholesterol and low density lipoprotein cholesterol (LDL-c) levels in association with entered diagnostic criteria and demographic data in five general practices...
November 15, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27884634/late-strut-fracture-within-a-partially-resorbed-bioresorbable-vascular-scaffold-a-possible-cause-of-late-scaffold-thrombosis-and-acute-coronary-syndrome
#2
Muhammad Asrar Ul Haq, Matthew Erickson, James Rankin, Alan Whelan
The Bioresorbable Vascular Scaffold (BVS, Abbott Vascular, Santa Clara, Cal, USA) is an exciting advance in percutaneous coronary intervention providing a temporary drug eluting scaffold resorbed in two to five years. We present two cases of late scaffold thrombosis associated with strut fracture during the period of resorption, at 20 and 24 months following BVS implantation. We propose luminal migration of malapposed struts following strut fracture during resorption as a potential mechanism for late scaffold thrombosis and acute coronary syndrome...
November 11, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27825758/response-to-beta-blockers-and-the-cardiac-complications-of-methamphetamines
#3
LETTER
Elizabeth D Paratz, Neil Cunningham, Andrew I MacIsaac
No abstract text is available yet for this article.
October 5, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27816421/pilot-study-of-endothelin-receptor-blockade-in-heart-failure-with-diastolic-dysfunction-and-pulmonary-hypertension-baddhy-trial
#4
B Koller, R Steringer-Mascherbauer, C H Ebner, Th Weber, M Ammer, J Eichinger, I Pretsch, M Herold, J Schwaiger, H Ulmer, W Grander
BACKGROUND: In this multi-centre, randomised, placebo-controlled pilot trial, we investigated the clinical and haemodynamic effects of the endothelin-receptor blocker Bosentan in patients with heart failure, preserved ejection fraction and pulmonary hypertension (PH-HFpEF). MATERIALS AND METHODS: Eligible patients received either 12 weeks of Bosentan therapy, or a placebo drug. Patients were thereafter followed for a further period of 12 weeks without the study medication...
September 28, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27743853/comparison-of-various-strategies-for-the-prognosis-and-outcomes-of-ischaemic-dilated-cardiomyopathy-in-smokers-complete-revascularisation-and-smoking-cessation-produces-a-superior-outcome
#5
Jiahong Wang, Lan Zhao, Jiarui Wei, Shaoheng Zhang, Nannan Chen, Dongxing Ding, Qunlin Gong, Feng Su, Jian Yan, Pengxiang Zheng
BACKGROUND: Various therapies have been used to improve the symptoms and prognosis of patients with coronary artery disease. However, comparative studies showing more suitable choices for patients with ischaemic dilated cardiomyopathy (IDCM) and who smoke cigarettes are lacking. METHODS: A total of 338 patients were divided into four groups according to whether they received complete revascularisation (CR), and/or underwent smoking cessation (SC). They were followed prospectively for 12 months...
September 26, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27743854/exenatide-prevents-morphological-and-structural-changes-of-mitochondria-following-ischaemia-reperfusion-injury
#6
Kyung Hye Lee, Sang Jin Ha, Jong-Shin Woo, Gi-Ja Lee, So-Ra Lee, Jung Wook Kim, Hun Kuk Park, Weon Kim
BACKGROUND: Exenatide exerts cardioprotective effects by attenuating ischaemic reperfusion injury, possibly through activating the opening of mitochondrial ATP-sensitive potassium channels. We used atomic force microscopy (AFM) to investigate changes in mitochondrial morphology and properties in order to assess exenatide-mediated cardioprotection in IR injury. METHODS: We used an in vivo Sprague-Dawley rat IR model and ex vivo Langendorff injury model. In the left anterior descending artery (LAD) occlusion model, animals were randomly divided into three groups: sham-operated rats (Sham, n=5), IR-injured rats treated with placebo (IR, n=6), and IR-injured treated with exenatide (IR + EXE, n=6)...
September 23, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27726955/cognitive-outcomes-of-cardiovascular-surgical-procedures-in-the-old-an-important-but-neglected-area
#7
Hannah A D Keage, Ashleigh Smith, Tobias Loetscher, Peter Psaltis
Older individuals can now undergo invasive cardiovascular procedures without serious concern about mortality, and the numbers and proportions of the over 65s and 85s doing so in Australia has been increasing over the last 20 years. There is overwhelming evidence linking cardiovascular conditions to late-life (65 years and over) cognitive impairment and dementia including Alzheimer's Disease, primarily due to impaired cerebrovascularisation and cascading neuropathological processes. Somewhat paradoxically, these cardiovascular interventions, carried out with the primary aim of revascularisation, are not usually associated with short- or long-term improvements in cognitive function in older adults...
September 23, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27746058/plasma-serotonin-in-heart-failure-possible-marker-and-potential-treatment-target
#8
Ahmed M Selim, Nitasha Sarswat, Iosif Kelesidis, Muhammad Iqbal, Ramesh Chandra, Ronald Zolty
BACKGROUND: The relationship between heart failure (HF) and the serotonergic system has been established in animal studies. However, data on human plasma serotonin level in HF and its significance over the course of the disease is lacking. METHODS: Serotonin levels were measured in 173 patients (108 males, 65 females), 116 were stable HF and 40 were acute decompensated HF patients. The normal control group included 17 healthy volunteers with no known medical or psychiatric conditions...
September 17, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27743856/intracardiac-leiomyomatosis-an-unusual-cause-of-syncope-in-a-middle-aged-woman
#9
Samuel J Fogarty, Graeme Hart, Jim Nicklin, Bala Venkatesh, Nicholas Boyne, David C Wong, Jason L Stone, Andrew J Rainbird
Intracardiac leiomyomatosis is a rare complication that occurs when a uterine leiomyoma (fibroid) undergoes vascular invasion and propagates within the inferior vena cava to reach the right atrium. This article describes a case of intracardiac leiomyomatosis in a middle-aged woman, exploring the presentation, diagnosis and surgical management of this condition. In this case the presenting complaints were syncope and atrial fibrillation, illustrating the importance of performing a transthoracic echocardiogram in patients presenting with their first episode of atrial fibrillation...
September 17, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27769753/efficacy-and-safety-of-statins-for-pulmonary-hypertension-a-meta-analysis-of-randomised-controlled-trials
#10
Yitao Zhang, Weijie Zeng, Shiyao Cheng, Zhichong Chen, Jiaojie Xue, Qing Wang, Maode Ou, Kanglin Cheng
BACKGROUND: Pulmonary hypertension (PH) is a serious disease, and treatment is a continuing challenge. Some in vitro and in vivo studies identified that statins were effective for PH. However, results of some randomised controlled trials (RCTs) have been controversial. The objective of our study was to clarify whether statins are effective and safe for pulmonary hypertension. METHODS: We systematically searched for eligible RCTs from PubMed, EMBASE, Web of Science, and the Cochrane Library during January 2016...
September 15, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27793556/unilateral-antegrade-cerebral-perfusion-and-moderate-hypothermia-assessing-safety-with-novel-biomarkers
#11
Bahadır Aytekin, Ertekin Utku Ünal, Aslı Demir, Uğur Aksu, Aytaç Çalışkan, Kübra Vardar, Fevzi Toraman, Ahmet Sarıtaş
BACKGROUND: Antegrade cerebral perfusion in aortic surgery is a well-established brain protection method. Open distal anastomosis during aortic surgery has some well-known advantages. Antegrade cerebral perfusion allows repair to some extent of the aortic arch, even in isolated ascending aortic aneurysm. The present study aims to investigate the adequacy of contralateral perfusion with novel oxidative stress parameters during unilateral antegrade cerebral perfusion. METHOD: The study included 30 consecutive patients undergoing thoracic aortic surgery with unilateral antegrade cerebral perfusion (uACP) under moderate hypothermia (28° C)...
September 13, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27769754/long-term-prognostic-value-of-a-negative-work-up-for-acute-coronary-disease-in-emergency-department-chest-pain-patients-without-known-coronary-artery-disease-a-cohort-study
#12
Anne-Maree Kelly, Sharon Klim
BACKGROUND: To determine the rate of all cause and cardiac death, new myocardial infarction (MI) or coronary revascularisation at over three years from index visit in emergency department chest pain patients without known coronary artery disease (CAD) at index presentation who had a negative electrocardiogram (ECG) and biomarker workup for acute coronary syndrome (ACS). METHODS: An unplanned sub-study of a prospective observational study of consecutive adult patients presenting to the ED with atraumatic chest pain (or equivalents)...
September 13, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27743855/effects-of-a-phase-iv-home-based-cardiac-rehabilitation-program-on-cardiorespiratory-fitness-and-physical-activity
#13
Andreia Noites, Carla Patrícia Freitas, Joana Pinto, Cristina Melo, Ágata Vieira, Aníbal Albuquerque, Madalena Teixeira, Fernando Ribeiro, José Mesquita Bastos
BACKGROUND: Cardiovascular diseases are the leading cause of death globally and sedentary lifestyle is one of the main risk factors. Home-based cardiac rehabilitation (CR) programs appear to be effective to improve exercise tolerance. The aim of the study, therefore, was to evaluate the effects of a phase IV (maintenance) home-based CR program on cardiorespiratory fitness and daily physical activity of patients recovering from an acute myocardial infarction. METHODS: This pilot study, with a sub-group randomised controlled trial, included 32 individuals recovering from a myocardial infarction, randomly divided into the experimental group (EG, n=16) and the control group (CG, n=16)...
September 13, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27771236/mesenchymal-stem-cells-expressing-enos-and-a-cav1-mutant-inhibit-vascular-smooth-muscle-cell-proliferation-in-a-rat-model-of-pulmonary-hypertension
#14
Haiying Chen, Hongli Yang, Hongmei Yue, Pádraig Michael Strappe, Peng Xia, Li Pan, Yingxin Zhang, Shoudong Chai, Shuangfeng Chen, Longle Ma, Lexin Wang
BACKGROUND: This study aimed to investigate the effect of bone marrow derived mesenchymal stem cells (rBMSCs) transduced with lentiviral vectors expressing endothelial nitric oxide synthase (eNOS) and/or a mutant caveolin-1(F92A-Cav1), on the pulmonary haemodynamics and structure in a rat model of pulmonary arterial hypertension (PAH). METHODS: Pulmonary arterial hypertension was induced with monocrotaline (MCT) in 60 adult male Wistar rats prior to delivery of lentiviral vector transduced rBMSCs expressing Cav1, eNOS and/or F92A-Cav1...
September 9, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27769756/intra-atrial-excision-of-the-left-atrial-appendage-a-simple-and-easy-technique
#15
Shigeaki Aoyagi, Eiki Tayama, Takeshi Oda, Tomokazu Kosuga, Hiroshi Yasunaga
In patients with atrial fibrillation, closure of the left atrial appendage (LAA) is recommended to prevent thromboembolic events, however, conventional exclusion or excision techniques have potential drawbacks such as persistent blood flow into the appendage and a residual stump. We propose a simple and easy technique for LAA closure consisting of intra-atrial excision of the LAA, which is invaginated into the left atrium (LA), and direct suture closure of the orifice from inside the LA. In this technique, complete elimination of the LAA was achieved without leaving a residual stump because the LAA was excised at the orifice and was closed at the base of the LAA...
September 9, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27780563/unusual-cause-of-persistent-chest-pain
#16
Ahmed Ghoneim, Nand Kejriwal
No abstract text is available yet for this article.
December 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27780562/heart-lung-and-circulation-evolves-a-fond-farewell-to-our-25-th-anniversary-year-and-a-warm-welcome-to-new-initiatives
#17
EDITORIAL
Ann T Gregory, A Robert Denniss
No abstract text is available yet for this article.
December 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27725094/corrigendum-to-circadian-rhythm-of-infarct-size-and-left-ventricular-function-evaluated-with-tissue-doppler-echocardiography-in-st-elevation-myocardial-infarction-heart-lung-and-circulation-25-2016-250-256
#18
Hatem Arı, Osman Sonmez, Fatih Koc, Yusuf Alıhanoglu, Kurtulus Ozdemır, Mehmet Akif Vatankulu
No abstract text is available yet for this article.
November 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27725093/intensive-ldl-reduction-post-acute-coronary-syndromes-a-catalyst-for-improved-outcomes
#19
Karam Kostner, Stephen Nicholls, John Amerena, Alex Brown, Mark Cooper, Chris Hammett, Richard O'Brien, Leonard Kritharides, David L Hare, Gerald F Watts, Philip Aylward, Karam Kostner, Stephen Nicholls, John Amerena, Alex Brown, Mark Cooper, Chris Hammett, Richard O'Brien, Leonard Kritharides, David L Hare, Gerald F Watts, Philip Aylward
No abstract text is available yet for this article.
November 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27725092/reflections-on-the-heart-foundation-of-australia-cardiac-society-of-australia-and-new-zealand-acute-coronary-syndromes-guideline-2016-a-new-international-benchmark
#20
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