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EMBO Reports

Anton Wutz
No abstract text is available yet for this article.
November 21, 2017: EMBO Reports
Ignacio Amigo, Alberto Pascual-García
No abstract text is available yet for this article.
November 20, 2017: EMBO Reports
Sumitra Tatapudy, Francesca Aloisio, Diane Barber, Todd Nystul
Understanding how cell fate decisions are regulated is a fundamental goal of developmental and stem cell biology. Most studies on the control of cell fate decisions address the contributions of changes in transcriptional programming, epigenetic modifications, and biochemical differentiation cues. However, recent studies have found that other aspects of cell biology also make important contributions to regulating cell fate decisions. These cues can have a permissive or instructive role and are integrated into the larger network of signaling, functioning both upstream and downstream of developmental signaling pathways...
November 20, 2017: EMBO Reports
Mingcan Yu, Patrizia D'Amelio, Abdul Malik Tyagi, Chiara Vaccaro, Jau-Yi Li, Emory Hsu, Ilaria Buondonno, Francesca Sassi, Jonathan Adams, M Neale Weitzmann, Richard DiPaolo, Roberto Pacifici
Teriparatide is a bone anabolic treatment for osteoporosis, modeled in animals by intermittent PTH (iPTH) administration, but the cellular and molecular mechanisms of action of iPTH are largely unknown. Here, we show that Teriparatide and iPTH cause a ~two-threefold increase in the number of regulatory T cells (Tregs) in humans and mice. Attesting in vivo relevance, blockade of the Treg increase in mice prevents the increase in bone formation and trabecular bone volume and structure induced by iPTH Therefore, increasing the number of Tregs is a pivotal mechanism by which iPTH exerts its bone anabolic activity...
November 20, 2017: EMBO Reports
Hanaa Hariri, Sean Rogers, Rupali Ugrankar, Yang Lydia Liu, J Ryan Feathers, W Mike Henne
Eukaryotic cells store lipids in cytosolic organelles known as lipid droplets (LDs). Lipid droplet bud from the endoplasmic reticulum (ER), and may be harvested by the vacuole for energy during prolonged periods of starvation. How cells spatially coordinate LD production is poorly understood. Here, we demonstrate that yeast ER-vacuole contact sites (NVJs) physically expand in response to metabolic stress, and serve as sites for LD production. NVJ tether Mdm1 demarcates sites of LD budding, and interacts with fatty acyl-CoA synthases at the NVJ periphery...
November 16, 2017: EMBO Reports
Arica Beisaw, Pavel Tsaytler, Frederic Koch, Sandra U Schmitz, Maria-Theodora Melissari, Anna D Senft, Lars Wittler, Tracie Pennimpede, Karol Macura, Bernhard G Herrmann, Phillip Grote
T-box transcription factors play essential roles in multiple aspects of vertebrate development. Here, we show that cooperative function of BRACHYURY (T) with histone-modifying enzymes is essential for mouse embryogenesis. A single point mutation (T(Y88A)) results in decreased histone 3 lysine 27 acetylation (H3K27ac) at T target sites, including the T locus, suggesting that T autoregulates the maintenance of its expression and functions by recruiting permissive chromatin modifications to putative enhancers during mesoderm specification...
November 15, 2017: EMBO Reports
Ok-Ryul Song, Christophe J Queval, Raffaella Iantomasi, Vincent Delorme, Sabrina Marion, Romain Veyron-Churlet, Elisabeth Werkmeister, Michka Popoff, Isabelle Ricard, Samuel Jouny, Nathalie Deboosere, Frank Lafont, Alain Baulard, Edouard Yeramian, Laurent Marsollier, Eik Hoffmann, Priscille Brodin
The interaction of Mycobacterium tuberculosis (Mtb) with pulmonary epithelial cells is critical for early stages of bacillus colonization and during the progression of tuberculosis. Entry of Mtb into epithelial cells has been shown to depend on F-actin polymerization, though the molecular mechanisms are still unclear. Here, we demonstrate that mycobacterial uptake into epithelial cells requires rearrangements of the actin cytoskeleton, which are regulated by ADP-ribosylation factor 1 (Arf1) and phospholipase D1 (PLD1), and is dependent on the M3 muscarinic receptor (M3R)...
November 15, 2017: EMBO Reports
Peter Sykora, Arthur Caplan
No abstract text is available yet for this article.
November 15, 2017: EMBO Reports
Françoise Baylis, Lisa Ikemoto
No abstract text is available yet for this article.
November 15, 2017: EMBO Reports
Cai Liang, Qinfu Chen, Qi Yi, Miao Zhang, Haiyan Yan, Bo Zhang, Linli Zhou, Zhenlei Zhang, Feifei Qi, Sheng Ye, Fangwei Wang
Sister-chromatid cohesion mediated by the cohesin complex is fundamental for precise chromosome segregation in mitosis. Through binding the cohesin subunit Pds5, Wapl releases the bulk of cohesin from chromosome arms in prophase, whereas centromeric cohesin is protected from Wapl until anaphase onset. Strong centromere cohesion requires centromeric localization of the mitotic histone kinase Haspin, which is dependent on the interaction of its non-catalytic N-terminus with Pds5B. It remains unclear how Haspin fully blocks the Wapl-Pds5B interaction at centromeres...
November 14, 2017: EMBO Reports
Philip Hunter
No abstract text is available yet for this article.
November 9, 2017: EMBO Reports
Richard Helliwell, Sarah Hartley, Warren Pearce, Liz O'Neill
No abstract text is available yet for this article.
November 2, 2017: EMBO Reports
Kourosh Gharun, Julia Senges, Maximilian Seidl, Anne Lösslein, Julia Kolter, Florens Lohrmann, Manfred Fliegauf, Magdeldin Elgizouli, Martina Vavra, Kristina Schachtrup, Anna L Illert, Martine Gilleron, Carsten J Kirschning, Antigoni Triantafyllopoulou, Philipp Henneke
Immunity to mycobacteria involves the formation of granulomas, characterized by a unique macrophage (MΦ) species, so-called multinucleated giant cells (MGC). It remains unresolved whether MGC are beneficial to the host, that is, by prevention of bacterial spread, or whether they promote mycobacterial persistence. Here, we show that the prototypical antimycobacterial molecule nitric oxide (NO), which is produced by MGC in excessive amounts, is a double-edged sword. Next to its antibacterial capacity, NO propagates the transformation of MΦ into MGC, which are relatively permissive for mycobacterial persistence...
November 2, 2017: EMBO Reports
Yunfei Qin, Zexiong Su, Yaoxing Wu, Chenglei Wu, Shouheng Jin, Weihong Xie, Wei Jiang, Rongbin Zhou, Jun Cui
MAVS signalosome plays an important role in RIG-I-like receptor (RLR)-induced antiviral signaling. Upon the recognition of viral RNAs, RLRs activate MAVS, which further recruits TRAF6 and other signaling proteins to initiate type I interferon (IFN) activation. MAVS signalosome also regulates virus-induced apoptosis to limit viral replication. However, the mechanisms that control the activity of MAVS signalosome are still poorly defined. Here, we report NLRP11, a Nod-like receptor, is induced by type I IFN and translocates to mitochondria to interact with MAVS upon viral infection...
November 2, 2017: EMBO Reports
Thomas Laboucarié, Dylane Detilleux, Ricard A Rodriguez-Mias, Céline Faux, Yves Romeo, Mirita Franz-Wachtel, Karsten Krug, Boris Maček, Judit Villén, Janni Petersen, Dominique Helmlinger
Gene expression regulation is essential for cells to adapt to changes in their environment. Co-activator complexes have well-established roles in transcriptional regulation, but less is known about how they sense and respond to signaling cues. We have previously shown that, in fission yeast, one such co-activator, the SAGA complex, controls gene expression and the switch from proliferation to differentiation in response to nutrient availability. Here, using a combination of genetic, biochemical, and proteomic approaches, we show that SAGA responds to nutrients through the differential phosphorylation of its Taf12 component, downstream of both the TORC1 and TORC2 pathways...
October 27, 2017: EMBO Reports
Matheus Sanitá Lima, David Roy Smith
No abstract text is available yet for this article.
October 27, 2017: EMBO Reports
Lidia Santos Silva, Gernot Poschet, Yannic Nonnenmacher, Holger M Becker, Sean Sapcariu, Ann-Christin Gaupel, Magdalena Schlotter, Yonghe Wu, Niclas Kneisel, Martina Seiffert, Rüdiger Hell, Karsten Hiller, Peter Lichter, Bernhard Radlwimmer
Elevated amino acid catabolism is common to many cancers. Here, we show that glioblastoma are excreting large amounts of branched-chain ketoacids (BCKAs), metabolites of branched-chain amino acid (BCAA) catabolism. We show that efflux of BCKAs, as well as pyruvate, is mediated by the monocarboxylate transporter 1 (MCT1) in glioblastoma. MCT1 locates in close proximity to BCKA-generating branched-chain amino acid transaminase 1, suggesting possible functional interaction of the proteins. Using in vitro models, we demonstrate that tumor-excreted BCKAs can be taken up and re-aminated to BCAAs by tumor-associated macrophages...
October 24, 2017: EMBO Reports
Ruslan Yatusevich, Halina Fedak, Arkadiusz Ciesielski, Katarzyna Krzyczmonik, Anna Kulik, Grazyna Dobrowolska, Szymon Swiezewski
Plants have developed multiple strategies to sense the external environment and to adapt growth accordingly. Delay of germination 1 (DOG1) is a major quantitative trait locus (QTL) for seed dormancy strength in Arabidopsis thaliana that is reported to be expressed exclusively in seeds. DOG1 is extensively regulated, with an antisense transcript (asDOG1) suppressing its expression in seeds. Here, we show that asDOG1 shows high levels in mature plants where it suppresses DOG1 expression under standard growth conditions...
October 13, 2017: EMBO Reports
Maria S Ioannou, Gopinath Kulasekaran, Maryam Fotouhi, Justin J Morein, Chanshuai Han, Sarah Tse, Nadya Nossova, Tony Han, Erin Mannard, Peter S McPherson
Epidermal growth factor (EGF) activates the EGF receptor (EGFR) and stimulates its internalization and trafficking to lysosomes for degradation. However, a percentage of EGFR undergoes ligand-independent endocytosis and is rapidly recycled back to the plasma membrane. Importantly, alterations in EGFR recycling are a common hallmark of cancer, and yet, our understanding of the machineries controlling the fate of endocytosed EGFR is incomplete. Intersectin-s is a multi-domain adaptor protein that is required for internalization of EGFR Here, we discover that intersectin-s binds DENND2B, a guanine nucleotide exchange factor for the exocytic GTPase Rab13, and this interaction promotes recycling of ligand-free EGFR to the cell surface...
October 13, 2017: EMBO Reports
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