journal
https://read.qxmd.com/read/38532128/liver-chrebp-deficiency-inhibits-fructose-induced-insulin-resistance-in-pregnant-mice-and-female-offspring
#1
JOURNAL ARTICLE
Jiaqi Li, Shuang Zhang, Yuyao Sun, Jian Li, Zian Feng, Huaxin Li, Mengxue Zhang, Tengteng Yan, Jihong Han, Yajun Duan
High fructose intake during pregnancy increases insulin resistance (IR) and gestational diabetes mellitus (GDM) risk. IR during pregnancy primarily results from elevated hormone levels. We aim to determine the role of liver carbohydrate response element binding protein (ChREBP) in insulin sensitivity and lipid metabolism in pregnant mice and their offspring. Pregnant C57BL/6J wild-type mice and hepatocyte-specific ChREBP-deficient mice were fed with a high-fructose diet (HFrD) or normal chow diet (NC) pre-delivery...
March 26, 2024: EMBO Reports
https://read.qxmd.com/read/38532127/security-challenges-by-ai-assisted-protein-design-the-ability-to-design-proteins-in-silico-could-pose-a-new-threat-for-biosecurity-and-biosafety
#2
JOURNAL ARTICLE
https://read.qxmd.com/read/38528171/jump-starting-life-balancing-transposable-element-co-option-and-genome-integrity-in-the-developing-mammalian-embryo
#3
REVIEW
Marlies E Oomen, Maria-Elena Torres-Padilla
Remnants of transposable elements (TEs) are widely expressed throughout mammalian embryo development. Originally infesting our genomes as selfish elements and acting as a source of genome instability, several of these elements have been co-opted as part of a complex system of genome regulation. Many TEs have lost transposition ability and their transcriptional potential has been tampered as a result of interactions with the host throughout evolutionary time. It has been proposed that TEs have been ultimately repurposed to function as gene regulatory hubs scattered throughout our genomes...
March 25, 2024: EMBO Reports
https://read.qxmd.com/read/38528170/high-allelic-diversity-in-arabidopsis-nlrs-is-associated-with-distinct-genomic-features
#4
JOURNAL ARTICLE
Chandler A Sutherland, Daniil M Prigozhin, J Grey Monroe, Ksenia V Krasileva
Plants rely on Nucleotide-binding, Leucine-rich repeat Receptors (NLRs) for pathogen recognition. Highly variable NLRs (hvNLRs) show remarkable intraspecies diversity, while their low-variability paralogs (non-hvNLRs) are conserved between ecotypes. At a population level, hvNLRs provide new pathogen-recognition specificities, but the association between allelic diversity and genomic and epigenomic features has not been established. Our investigation of NLRs in Arabidopsis Col-0 has revealed that hvNLRs show higher expression, less gene body cytosine methylation, and closer proximity to transposable elements than non-hvNLRs...
March 25, 2024: EMBO Reports
https://read.qxmd.com/read/38509354/ai-to-publish-knowledge-a-tectonic-shift
#5
EDITORIAL
Thomas Lemberger
No abstract text is available yet for this article.
March 20, 2024: EMBO Reports
https://read.qxmd.com/read/38509353/redefining-meaning-and-success-in-science-research-and-teaching
#6
REVIEW
David R Smith
No abstract text is available yet for this article.
March 20, 2024: EMBO Reports
https://read.qxmd.com/read/38503877/stinging-organelle-surface-with-acid
#7
JOURNAL ARTICLE
Yoshihiko Kuchitsu, Tomohiko Taguchi
No abstract text is available yet for this article.
March 19, 2024: EMBO Reports
https://read.qxmd.com/read/38499810/new-plastids-old-proteins-repeated-endosymbiotic-acquisitions-in-kareniacean-dinoflagellates
#8
JOURNAL ARTICLE
Anna Mg Novák Vanclová, Charlotte Nef, Zoltán Füssy, Adél Vancl, Fuhai Liu, Chris Bowler, Richard G Dorrell
Dinoflagellates are a diverse group of ecologically significant micro-eukaryotes that can serve as a model system for plastid symbiogenesis due to their susceptibility to plastid loss and replacement via serial endosymbiosis. Kareniaceae harbor fucoxanthin-pigmented plastids instead of the ancestral peridinin-pigmented ones and support them with a diverse range of nucleus-encoded plastid-targeted proteins originating from the haptophyte endosymbiont, dinoflagellate host, and/or lateral gene transfers (LGT)...
March 18, 2024: EMBO Reports
https://read.qxmd.com/read/38499809/transcript-specific-induction-of-stop-codon-readthrough-using-a-crispr-dcas13-system
#9
JOURNAL ARTICLE
Lekha E Manjunath, Anumeha Singh, Sangeetha Devi Kumar, Kirtana Vasu, Debaleena Kar, Karthi Sellamuthu, Sandeep M Eswarappa
Stop codon readthrough (SCR) is the process where translation continues beyond a stop codon on an mRNA. Here, we describe a strategy to enhance or induce SCR in a transcript-selective manner using a CRISPR-dCas13 system. Using specific guide RNAs, we target dCas13 to the region downstream of canonical stop codons of mammalian AGO1 and VEGFA mRNAs, known to exhibit natural SCR. Readthrough assays reveal enhanced SCR of these mRNAs (both exogenous and endogenous) caused by the dCas13-gRNA complexes. This effect is associated with ribosomal pausing, which has been reported for several SCR events...
March 18, 2024: EMBO Reports
https://read.qxmd.com/read/38499808/sorla-restricts-tnf%C3%AE-release-from-microglia-to-shape-a-glioma-supportive-brain-microenvironment
#10
JOURNAL ARTICLE
Paulina Kaminska, Peter L Ovesen, Mateusz Jakiel, Tomasz Obrebski, Vanessa Schmidt, Michal Draminski, Aleksandra G Bilska, Magdalena Bieniek, Jasper Anink, Bohdan Paterczyk, Anne Mette Gissel Jensen, Sylwia Piatek, Olav M Andersen, Eleonora Aronica, Thomas E Willnow, Bozena Kaminska, Michal J Dabrowski, Anna R Malik
SorLA, encoded by the gene SORL1, is an intracellular sorting receptor of the VPS10P domain receptor gene family. Although SorLA is best recognized for its ability to shuttle target proteins between intracellular compartments in neurons, recent data suggest that also its microglial expression can be of high relevance for the pathogenesis of brain diseases, including glioblastoma (GBM). Here, we interrogated the impact of SorLA on the functional properties of glioma-associated microglia and macrophages (GAMs)...
March 18, 2024: EMBO Reports
https://read.qxmd.com/read/38491313/appropriate-glycemic-management-protects-the-germline-but-not-the-uterine-environment-in-hyperglycemia
#11
JOURNAL ARTICLE
Allan Zhao, Hong Jiang, Arturo Reyes Palomares, Alice Larsson, Wenteng He, Jacob Grünler, Xiaowei Zheng, Kenny A Rodriguez Wallberg, Sergiu-Bogdan Catrina, Qiaolin Deng
Emerging evidence indicates that parental diseases can impact the health of subsequent generations through epigenetic inheritance. Recently, it was shown that maternal diabetes alters the metaphase II oocyte transcriptome, causing metabolic dysfunction in offspring. However, type 1 diabetes (T1D) mouse models frequently utilized in previous studies may be subject to several confounding factors due to severe hyperglycemia. This limits clinical translatability given improvements in glycemic control for T1D subjects...
March 15, 2024: EMBO Reports
https://read.qxmd.com/read/38480846/the-functional-significance-of-the-rpa-and-pcna-dependent-recruitment-of-pif1-to-dna
#12
JOURNAL ARTICLE
Oleksii Kotenko, Svetlana Makovets
Pif1 family helicases are multifunctional proteins conserved in eukaryotes, from yeast to humans. They are important for the genome maintenance in both nuclei and mitochondria, where they have been implicated in Okazaki fragment processing, replication fork progression and termination, telomerase regulation and DNA repair. While the Pif1 helicase activity is readily detectable on naked nucleic acids in vitro, the in vivo functions rely on recruitment to DNA. We identify the single-stranded DNA binding protein complex RPA as the major recruiter of Pif1 in budding yeast, in addition to the previously reported Pif1-PCNA interaction...
March 13, 2024: EMBO Reports
https://read.qxmd.com/read/38480845/prodh-safeguards-human-naive-pluripotency-by-limiting-mitochondrial-oxidative-phosphorylation-and-reactive-oxygen-species-production
#13
JOURNAL ARTICLE
Cheng Chen, Qianyu Liu, Wenjie Chen, Zhiyuan Gong, Bo Kang, Meihua Sui, Liming Huang, Ying-Jie Wang
Naive human embryonic stem cells (hESCs) that resemble the pre-implantation epiblasts are fueled by a combination of aerobic glycolysis and oxidative phosphorylation, but their mitochondrial regulators are poorly understood. Here we report that, proline dehydrogenase (PRODH), a mitochondria-localized proline metabolism enzyme, is dramatically upregulated in naive hESCs compared to their primed counterparts. The upregulation of PRODH is induced by a reduction in c-Myc expression that is dependent on PD0325901, a MEK inhibitor routinely present in naive hESC culture media...
March 13, 2024: EMBO Reports
https://read.qxmd.com/read/38467907/the-tam-a-translocation-and-assembly-module-for-protein-assembly-and-potential-conduit-for-phospholipid-transfer
#14
REVIEW
Kwok Jian Goh, Christopher J Stubenrauch, Trevor Lithgow
The assembly of β-barrel proteins into the bacterial outer membrane is an essential process enabling the colonization of new environmental niches. The TAM was discovered as a module of the β-barrel protein assembly machinery; it is a heterodimeric complex composed of an outer membrane protein (TamA) bound to an inner membrane protein (TamB). The TAM spans the periplasm, providing a scaffold through the peptidoglycan layer and catalyzing the translocation and assembly of β-barrel proteins into the outer membrane...
March 11, 2024: EMBO Reports
https://read.qxmd.com/read/38454159/bag5-regulates-hspa8-mediated-protein-folding-required-for-sperm-head-tail-coupling-apparatus-assembly
#15
JOURNAL ARTICLE
Shiming Gan, Shumin Zhou, Jinzhe Ma, Mengneng Xiong, Wenjing Xiong, Xu Fan, Kuan Liu, Yiqian Gui, Bei Chen, Beibei Zhang, Xiaoli Wang, Fengli Wang, Zhean Li, Wei Yan, Meisheng Ma, Shuiqiao Yuan
Teratozoospermia is a significant cause of male infertility, but the pathogenic mechanism of acephalic spermatozoa syndrome (ASS), one of the most severe teratozoospermia, remains elusive. We previously reported Spermatogenesis Associated 6 (SPATA6) as the component of the sperm head-tail coupling apparatus (HTCA) required for normal assembly of the sperm head-tail conjunction, but the underlying molecular mechanism has not been explored. Here, we find that the co-chaperone protein BAG5, expressed in step 9-16 spermatids, is essential for sperm HTCA assembly...
March 7, 2024: EMBO Reports
https://read.qxmd.com/read/38454158/%C3%AE-melanocyte-stimulating-hormone-alleviates-pathological-cardiac-remodeling-via-melanocortin-5-receptor
#16
JOURNAL ARTICLE
Anni Suominen, Guillem Saldo Rubio, Saku Ruohonen, Zoltán Szabó, Lotta Pohjolainen, Bishwa Ghimire, Suvi T Ruohonen, Karla Saukkonen, Jani Ijas, Sini Skarp, Leena Kaikkonen, Minying Cai, Sharon L Wardlaw, Heikki Ruskoaho, Virpi Talman, Eriika Savontaus, Risto Kerkelä, Petteri Rinne
α-Melanocyte-stimulating hormone (α-MSH) regulates diverse physiological functions by activating melanocortin receptors (MC-R). However, the role of α-MSH and its possible target receptors in the heart remain completely unknown. Here we investigate whether α-MSH could be involved in pathological cardiac remodeling. We found that α-MSH was highly expressed in the mouse heart with reduced ventricular levels after transverse aortic constriction (TAC). Administration of a stable α-MSH analog protected mice against TAC-induced cardiac hypertrophy and systolic dysfunction...
March 7, 2024: EMBO Reports
https://read.qxmd.com/read/38438802/identification-of-plants-functional-counterpart-of-the-metazoan-mediator-of-dna-damage-checkpoint-1
#17
JOURNAL ARTICLE
Zdravko J Lorković, Michael Klingenbrunner, Chung Hyun Cho, Frédéric Berger
Induction of DNA damage triggers rapid phosphorylation of the histone H2A.X (γH2A.X). In animals, mediator of DNA damage checkpoint 1 (MDC1) binds γH2A.X through a tandem BRCA1 carboxyl-terminal (tBRCT) domain and mediates recruitment of downstream effectors of DNA damage response (DDR). However, readers of this modification in plants have remained elusive. We show that from the Arabidopsis BRCT domain proteome, BCP1-4 proteins with tBRCT domains are involved in DDR. Through its tBRCT domain BCP4 binds γH2A...
March 4, 2024: EMBO Reports
https://read.qxmd.com/read/38438801/the-ethical-and-legal-challenges-of-human-foetal-brain-tissue-derived-organoids-at-the-intersection-of-science-ethics-and-regulation
#18
JOURNAL ARTICLE
Tsutomu Sawai, Masanori Kataoka
No abstract text is available yet for this article.
March 4, 2024: EMBO Reports
https://read.qxmd.com/read/38429580/author-correction-toll-like-receptor-9-protects-non-immune-cells-from-stress-by-modulating-mitochondrial-atp-synthesis-through-the-inhibition-of-serca2
#19
Yasunori Shintani, Hannes Ca Drexler, Hidetaka Kioka, Cesare Mn Terracciano, Steven R Coppen, Hiromi Imamura, Masaharu Akao, Junichi Nakai, Ann P Wheeler, Shuichiro Higo, Hiroyuki Nakayama, Seiji Takashima, Kenta Yashiro, Ken Suzuki
No abstract text is available yet for this article.
March 1, 2024: EMBO Reports
https://read.qxmd.com/read/38429579/phf6-mediated-transcriptional-control-of-nsc-via-ephrin-receptors-is-impaired-in-the-intellectual-disability-syndrome-bfls
#20
JOURNAL ARTICLE
Dilan Rasool, Audrey Burban, Ahmad Sharanek, Ariel Madrigal, Jinghua Hu, Keqin Yan, Dianbo Qu, Anne K Voss, Ruth S Slack, Tim Thomas, Azad Bonni, David J Picketts, Vahab D Soleimani, Hamed S Najafabadi, Arezu Jahani-Asl
The plant homeodomain zinc-finger protein, PHF6, is a transcriptional regulator, and PHF6 germline mutations cause the X-linked intellectual disability (XLID) Börjeson-Forssman-Lehmann syndrome (BFLS). The mechanisms by which PHF6 regulates transcription and how its mutations cause BFLS remain poorly characterized. Here, we show genome-wide binding of PHF6 in the developing cortex in the vicinity of genes involved in central nervous system development and neurogenesis. Characterization of BFLS mice harbouring PHF6 patient mutations reveals an increase in embryonic neural stem cell (eNSC) self-renewal and a reduction of neural progenitors...
March 1, 2024: EMBO Reports
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