Paulina Kaminska, Peter L Ovesen, Mateusz Jakiel, Tomasz Obrebski, Vanessa Schmidt, Michal Draminski, Aleksandra G Bilska, Magdalena Bieniek, Jasper Anink, Bohdan Paterczyk, Anne Mette Gissel Jensen, Sylwia Piatek, Olav M Andersen, Eleonora Aronica, Thomas E Willnow, Bozena Kaminska, Michal J Dabrowski, Anna R Malik
SorLA, encoded by the gene SORL1, is an intracellular sorting receptor of the VPS10P domain receptor gene family. Although SorLA is best recognized for its ability to shuttle target proteins between intracellular compartments in neurons, recent data suggest that also its microglial expression can be of high relevance for the pathogenesis of brain diseases, including glioblastoma (GBM). Here, we interrogated the impact of SorLA on the functional properties of glioma-associated microglia and macrophages (GAMs)...
March 18, 2024: EMBO Reports