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EMBO Reports

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https://www.readbyqxmd.com/read/28931580/the-biosocial-genome-interdisciplinary-perspectives-on-environmental-epigenetics-health-and-society
#1
Ruth Müller, Clare Hanson, Mark Hanson, Michael Penkler, Georgia Samaras, Luca Chiapperino, John Dupré, Martha Kenney, Christopher Kuzawa, Joanna Latimer, Stephanie Lloyd, Astrid Lunkes, Molly Macdonald, Maurizio Meloni, Brigitte Nerlich, Francesco Panese, Martyn Pickersgill, Sarah Richardson, Joëlle Rüegg, Sigrid Schmitz, Aleksandra Stelmach, Paula-Irene Villa
No abstract text is available yet for this article.
September 20, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28928140/selenoprotein-t-is-a-novel-ost-subunit-that-regulates-upr-signaling-and-hormone-secretion
#2
Abdallah Hamieh, Dorthe Cartier, Houssni Abid, André Calas, Carole Burel, Christine Bucharles, Cedric Jehan, Luca Grumolato, Marc Landry, Patrice Lerouge, Youssef Anouar, Isabelle Lihrmann
Selenoprotein T (SelT) is a recently characterized thioredoxin-like protein whose expression is very high during development, but is confined to endocrine tissues in adulthood where its function is unknown. We report here that SelT is required for adaptation to the stressful conditions of high hormone level production in endocrine cells. Using immunofluorescence and TEM immunogold approaches, we find that SelT is expressed at the endoplasmic reticulum membrane in all hormone-producing pituitary cell types. SelT knockdown in corticotrope cells promotes unfolded protein response (UPR) and ER stress and lowers endoplasmic reticulum-associated protein degradation (ERAD) and hormone production...
September 19, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28928139/a-cooperative-governance-network-for-crop-genome-editing-the-success-of-governance-networks-in-other-areas-could-help-to-find-common-ground-for-applying-genome-editing-in-agriculture
#3
Nicholas R Jordan, Kevin M Dorn, Timothy M Smith, Katie E Wolf, Patrick M Ewing, Adria L Fernandez, Bryan C Runck, Alwyn Williams, You Lu, Jennifer Kuzma
No abstract text is available yet for this article.
September 19, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28912123/type-vi-secretion-system-mix-effectors-carry-both-antibacterial-and-anti-eukaryotic-activities
#4
Ann Ray, Nika Schwartz, Marcela de Souza Santos, Junmei Zhang, Kim Orth, Dor Salomon
Most type VI secretion systems (T6SSs) described to date are protein delivery apparatuses that mediate bactericidal activities. Several T6SSs were also reported to mediate virulence activities, although only few anti-eukaryotic effectors have been described. Here, we identify three T6SSs in the marine bacterium Vibrio proteolyticus and show that T6SS1 mediates bactericidal activities under warm marine-like conditions. Using comparative proteomics, we find nine potential T6SS1 effectors, five of which belong to the polymorphic MIX-effector class...
September 14, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28893864/the-beach-protein-lrba-is-required-for-hair-bundle-maintenance-in-cochlear-hair-cells-and-for-hearing
#5
Christian Vogl, Tanvi Butola, Natja Haag, Torben J Hausrat, Michael G Leitner, Michel Moutschen, Philippe P Lefèbvre, Carsten Speckmann, Lillian Garrett, Lore Becker, Helmut Fuchs, Martin Hrabe de Angelis, Sandor Nietzsche, Michael M Kessels, Dominik Oliver, Matthias Kneussel, Manfred W Kilimann, Nicola Strenzke
Lipopolysaccharide-responsive beige-like anchor protein (LRBA) belongs to the enigmatic class of BEACH domain-containing proteins, which have been attributed various cellular functions, typically involving intracellular protein and membrane transport processes. Here, we show that LRBA deficiency in mice leads to progressive sensorineural hearing loss. In LRBA knockout mice, inner and outer hair cell stereociliary bundles initially develop normally, but then partially degenerate during the second postnatal week...
September 11, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28893863/bin1-directly-remodels-actin-dynamics-through-its-bar-domain
#6
Nina M Dräger, Eliana Nachman, Moritz Winterhoff, Stefan Brühmann, Pranav Shah, Taxiarchis Katsinelos, Steeve Boulant, Aurelio A Teleman, Jan Faix, Thomas R Jahn
Endocytic processes are facilitated by both curvature-generating BAR-domain proteins and the coordinated polymerization of actin filaments. Under physiological conditions, the N-BAR protein Bin1 has been shown to sense and curve membranes in a variety of cellular processes. Recent studies have identified Bin1 as a risk factor for Alzheimer's disease, although its possible pathological function in neurodegeneration is currently unknown. Here, we report that Bin1 not only shapes membranes, but is also directly involved in actin binding through its BAR domain...
September 11, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28887322/kinesin-2-motors-adapt-their-stepping-behavior-for-processive-transport-on-axonemes-and-microtubules
#7
Willi L Stepp, Georg Merck, Felix Mueller-Planitz, Zeynep Ökten
Two structurally distinct filamentous tracks, namely singlet microtubules in the cytoplasm and axonemes in the cilium, serve as railroads for long-range transport processes in vivo In all organisms studied so far, the kinesin-2 family is essential for long-range transport on axonemes. Intriguingly, in higher eukaryotes, kinesin-2 has been adapted to work on microtubules in the cytoplasm as well. Here, we show that heterodimeric kinesin-2 motors distinguish between axonemes and microtubules. Unlike canonical kinesin-1, kinesin-2 takes directional, off-axis steps on microtubules, but it resumes a straight path when walking on the axonemes...
September 8, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28887321/lncrna-pagbc-acts-as-a-microrna-sponge-and-promotes-gallbladder-tumorigenesis
#8
Xiang-Song Wu, Fang Wang, Huai-Feng Li, Yun-Ping Hu, Lin Jiang, Fei Zhang, Mao-Lan Li, Xu-An Wang, Yun-Peng Jin, Yi-Jian Zhang, Wei Lu, Wen-Guang Wu, Yi-Jun Shu, Hao Weng, Yang Cao, Run-Fa Bao, Hai-Bin Liang, Zheng Wang, Yi-Chi Zhang, Wei Gong, Lei Zheng, Shu-Han Sun, Ying-Bin Liu
Long noncoding RNAs (lncRNAs) play roles in the development and progression of many cancers; however, the contributions of lncRNAs to human gallbladder cancer (GBC) remain largely unknown. In this study, we identify a group of differentially expressed lncRNAs in human GBC tissues, including prognosis-associated gallbladder cancer lncRNA (lncRNA-PAGBC), which we find to be an independent prognostic marker in GBC Functional analysis indicates that lncRNA-PAGBC promotes tumour growth and metastasis of GBC cells...
September 8, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28887320/p53-gain-of-function-mutations-increase-cdc7-dependent-replication-initiation
#9
Arindam Datta, Dishari Ghatak, Sumit Das, Taraswi Banerjee, Anindita Paul, Ramesh Butti, Mahadeo Gorain, Sangeeta Ghuwalewala, Anirban Roychowdhury, Sk Kayum Alam, Pijush Das, Raghunath Chatterjee, Maitrayee Dasgupta, Chinmay Kumar Panda, Gopal C Kundu, Susanta Roychoudhury
Cancer-associated p53 missense mutants confer gain of function (GOF) and promote tumorigenesis by regulating crucial signaling pathways. However, the role of GOF mutant p53 in regulating DNA replication, a commonly altered pathway in cancer, is less explored. Here, we show that enhanced Cdc7-dependent replication initiation enables mutant p53 to confer oncogenic phenotypes. We demonstrate that mutant p53 cooperates with the oncogenic transcription factor Myb in vivo and transactivates Cdc7 in cancer cells...
September 8, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28887319/cold-stress-induced-ferroptosis-involves-the-ask1-p38-pathway
#10
Kazuki Hattori, Hiroyuki Ishikawa, Chihiro Sakauchi, Saki Takayanagi, Isao Naguro, Hidenori Ichijo
A wide variety of cell death mechanisms, such as ferroptosis, have been proposed in mammalian cells, and the classification of cell death attracts global attention because each type of cell death has the potential to play causative roles in specific diseases. However, the precise molecular mechanisms leading to cell death are poorly understood, particularly in ferroptosis. Here, we show that continuous severe cold stress induces ferroptosis and the ASK1-p38 MAPK pathway in multiple cell lines. The activation of the ASK1-p38 pathway is mediated by critical determinants of ferroptosis: MEK activity, iron ions, and lipid peroxide...
September 8, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28887318/ubcd1-regulates-hedgehog-signaling-by-directly-modulating-ci-ubiquitination-and-processing
#11
Chenyu Pan, Yue Xiong, Xiangdong Lv, Yuanxin Xia, Shuo Zhang, Hao Chen, Jialin Fan, Wenqing Wu, Feng Liu, Hailong Wu, Zhaocai Zhou, Lei Zhang, Yun Zhao
The Hh pathway controls many morphogenetic processes in metazoans and plays important roles in numerous pathologies and in cancer. Hh signaling is mediated by the activity of the Gli/Ci family of transcription factors. Several studies in Drosophila have shown that ubiquitination by the ubiquitin E3 ligases Slimb and Rdx(Hib) plays a crucial role in controlling Ci stability dependent on the levels of Hh signals. If Hh levels are low, Slimb adds K11- and K48-linked poly-ubiquitin chains on Ci resulting in partial degradation...
September 8, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28877930/viral-taxonomy-the-effect-of-metagenomics-on-understanding-the-diversity-and-evolution-of-viruses
#12
Philip Hunter
No abstract text is available yet for this article.
September 6, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28864816/swimming-in-a-sea-of-drugs-psychiatric-drugs-in-the-aquatic-environment-could-have-severe-adverse-effects-on-wildlife-and-ecosystems
#13
Katrin Weigmann
No abstract text is available yet for this article.
September 1, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28855306/il-23-drives-differentiation-of-peripheral-%C3%AE-%C3%AE-17-t-cells-from-adult-bone-marrow-derived-precursors
#14
Pedro H Papotto, Natacha Gonçalves-Sousa, Nina Schmolka, Andrea Iseppon, Sofia Mensurado, Brigitta Stockinger, Julie C Ribot, Bruno Silva-Santos
Pro-inflammatory interleukin (IL)-17-producing γδ (γδ17) T cells are thought to develop exclusively in the thymus during fetal/perinatal life, as adult bone marrow precursors fail to generate γδ17 T cells under homeostatic conditions. Here, we employ a model of experimental autoimmune encephalomyelitis (EAE) in which hematopoiesis is reset by bone marrow transplantation and demonstrate unequivocally that Vγ4(+) γδ17 T cells can develop de novo in draining lymph nodes in response to innate stimuli...
August 30, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28835548/chromatin-remodeling-a-complex-affair
#15
Nathan Gioacchini, Craig L Peterson
No abstract text is available yet for this article.
August 23, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28835547/ifitm3-requires-an-amphipathic-helix-for-antiviral-activity
#16
Nicholas M Chesarino, Alex A Compton, Temet M McMichael, Adam D Kenney, Lizhi Zhang, Victoria Soewarna, Matthew Davis, Olivier Schwartz, Jacob S Yount
Interferon-induced transmembrane protein 3 (IFITM3) is a cellular factor that blocks virus fusion with cell membranes. IFITM3 has been suggested to alter membrane curvature and fluidity, though its exact mechanism of action is unclear. Using a bioinformatic approach, we predict IFITM3 secondary structures and identify a highly conserved, short amphipathic helix within a hydrophobic region of IFITM3 previously thought to be a transmembrane domain. Consistent with the known ability of amphipathic helices to alter membrane properties, we show that this helix and its amphipathicity are required for the IFITM3-dependent inhibition of influenza virus, Zika virus, vesicular stomatitis virus, Ebola virus, and human immunodeficiency virus infections...
August 23, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28835546/er-remodeling-by-the-large-gtpase-atlastin-promotes-vacuolar-growth-of-legionella-pneumophila
#17
Bernhard Steiner, Anna Leoni Swart, Amanda Welin, Stephen Weber, Nicolas Personnic, Andres Kaech, Christophe Freyre, Urs Ziegler, Robin W Klemm, Hubert Hilbi
The pathogenic bacterium Legionella pneumophila replicates in host cells within a distinct ER-associated compartment termed the Legionella-containing vacuole (LCV). How the dynamic ER network contributes to pathogen proliferation within the nascent LCV remains elusive. A proteomic analysis of purified LCVs identified the ER tubule-resident large GTPase atlastin3 (Atl3, yeast Sey1p) and the reticulon protein Rtn4 as conserved LCV host components. Here, we report that Sey1/Atl3 and Rtn4 localize to early LCVs and are critical for pathogen vacuole formation...
August 23, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28835545/rab7b-modulates-autophagic-flux-by-interacting-with-atg4b
#18
Ingrid Kjos, Marita Borg Distefano, Frank Sætre, Urska Repnik, Petter Holland, Arwyn T Jones, Nikolai Engedal, Anne Simonsen, Oddmund Bakke, Cinzia Progida
Autophagy (macroautophagy) is a highly conserved eukaryotic degradation pathway in which cytosolic components and organelles are sequestered by specialized autophagic membranes and degraded through the lysosomal system. The autophagic pathway maintains basal cellular homeostasis and helps cells adapt during stress; thus, defects in autophagy can cause detrimental effects. It is therefore crucial that autophagy is properly regulated. In this study, we show that the cysteine protease Atg4B, a key enzyme in autophagy that cleaves LC3, is an interactor of the small GTPase Rab7b...
August 23, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28827471/length-does-matter-for-cgas
#19
Michael P Gantier
No abstract text is available yet for this article.
August 21, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28827470/visualization-of-cytosolic-ribosomes-on-the-surface-of-mitochondria-by-electron-cryo-tomography
#20
Vicki Am Gold, Piotr Chroscicki, Piotr Bragoszewski, Agnieszka Chacinska
We employed electron cryo-tomography to visualize cytosolic ribosomes on the surface of mitochondria. Translation-arrested ribosomes reveal the clustered organization of the TOM complex, corroborating earlier reports of localized translation. Ribosomes are shown to interact specifically with the TOM complex, and nascent chain binding is crucial for ribosome recruitment and stabilization. Ribosomes are bound to the membrane in discrete clusters, often in the vicinity of the crista junctions. This interaction highlights how protein synthesis may be coupled with transport...
August 21, 2017: EMBO Reports
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