journal
MENU ▼
Read by QxMD icon Read
search

Nature Reviews. Molecular Cell Biology

journal
https://www.readbyqxmd.com/read/27899823/cell-migration-let-your-fingers-do-the-walking
#1
Paulina Strzyz
No abstract text is available yet for this article.
November 30, 2016: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/27876786/a-view-of-human-haematopoietic-development-from-the-petri-dish
#2
Andrea Ditadi, Christopher M Sturgeon, Gordon Keller
Human pluripotent stem cells (hPSCs) provide an unparalleled opportunity to establish in vitro differentiation models that will transform our approach to the study of human development. In the case of the blood system, these models will enable investigation of the earliest stages of human embryonic haematopoiesis that was previously not possible. In addition, they will provide platforms for studying the origins of human blood cell diseases and for generating de novo haematopoietic stem and progenitor cell populations for cell-based regenerative therapies...
November 23, 2016: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/27847391/the-roles-of-rna-processing-in-translating-genotype-to-phenotype
#3
Kassie S Manning, Thomas A Cooper
A goal of human genetics studies is to determine the mechanisms by which genetic variation produces phenotypic differences that affect human health. Efforts in this respect have previously focused on genetic variants that affect mRNA levels by altering epigenetic and transcriptional regulation. Recent studies show that genetic variants that affect RNA processing are at least equally as common as, and are largely independent from, those variants that affect transcription. We highlight the impact of genetic variation on pre-mRNA splicing and polyadenylation, and on the stability, translation and structure of mRNAs as mechanisms that produce phenotypic traits...
November 16, 2016: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/27808276/post-transcriptional-gene-regulation-by-mrna-modifications
#4
Boxuan Simen Zhao, Ian A Roundtree, Chuan He
The recent discovery of reversible mRNA methylation has opened a new realm of post-transcriptional gene regulation in eukaryotes. The identification and functional characterization of proteins that specifically recognize RNA N(6)-methyladenosine (m(6)A) unveiled it as a modification that cells utilize to accelerate mRNA metabolism and translation. N(6)-adenosine methylation directs mRNAs to distinct fates by grouping them for differential processing, translation and decay in processes such as cell differentiation, embryonic development and stress responses...
November 3, 2016: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/27703243/reverse-topology-membrane-scission-by-the-escrt-proteins
#5
Johannes Schöneberg, Il-Hyung Lee, Janet H Iwasa, James H Hurley
The narrow membrane necks formed during viral, exosomal and intra-endosomal budding from membranes, as well as during cytokinesis and related processes, have interiors that are contiguous with the cytosol. Severing these necks involves action from the opposite face of the membrane as occurs during the well-characterized formation of coated vesicles. This 'reverse' (or 'inverse')-topology membrane scission is carried out by the endosomal sorting complex required for transport (ESCRT) proteins, which form filaments, flat spirals, tubes and conical funnels that are thought to direct membrane remodelling and scission...
October 5, 2016: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/27677860/alternative-polyadenylation-of-mrna-precursors
#6
Bin Tian, James L Manley
Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct 3' termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all eukaryotic species and is recognized as a major mechanism of gene regulation. APA exhibits tissue specificity and is important for cell proliferation and differentiation. In this Review, we discuss the roles of APA in diverse cellular processes, including mRNA metabolism, protein diversification and protein localization, and more generally in gene regulation...
September 28, 2016: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/27677859/mechanisms-and-in-vivo-functions-of-contact-inhibition-of-locomotion
#7
Brian Stramer, Roberto Mayor
Contact inhibition of locomotion (CIL) is a process whereby a cell ceases motility or changes its trajectory upon collision with another cell. CIL was initially characterized more than half a century ago and became a widely studied model system to understand how cells migrate and dynamically interact. Although CIL fell from interest for several decades, the scientific community has recently rediscovered this process. We are now beginning to understand the precise steps of this complex behaviour and to elucidate its regulatory components, including receptors, polarity proteins and cytoskeletal elements...
September 28, 2016: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/27677857/organelle-dynamics-sizing-mitochondria-with-phospholipids
#8
Paulina Strzyz
No abstract text is available yet for this article.
September 28, 2016: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/27649881/cytoskeleton-patching-up-microtubule-growth
#9
Paulina Strzyz
No abstract text is available yet for this article.
September 21, 2016: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/27649880/roles-of-eukaryotic-topoisomerases-in-transcription-replication-and-genomic-stability
#10
Yves Pommier, Yilun Sun, Shar-Yin N Huang, John L Nitiss
Topoisomerases introduce transient DNA breaks to relax supercoiled DNA, remove catenanes and enable chromosome segregation. Human cells encode six topoisomerases (TOP1, TOP1mt, TOP2α, TOP2β, TOP3α and TOP3β), which act on a broad range of DNA and RNA substrates at the nuclear and mitochondrial genomes. Their catalytic intermediates, the topoisomerase cleavage complexes (TOPcc), are therapeutic targets of various anticancer drugs. TOPcc can also form on damaged DNA during replication and transcription, and engage specific repair pathways, such as those mediated by tyrosyl-DNA phosphodiesterase 1 (TDP1) and TDP2 and by endonucleases (MRE11, XPF-ERCC1 and MUS81)...
September 21, 2016: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/27826148/plant-cell-biology-blue-light-gives-cry-the-blues
#11
Eytan Zlotorynski
No abstract text is available yet for this article.
December 2016: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/27826147/regulation-of-disease-associated-gene-expression-in-the-3d-genome
#12
Peter Hugo Lodewijk Krijger, Wouter de Laat
Genetic variation associated with disease often appears in non-coding parts of the genome. Understanding the mechanisms by which this phenomenon leads to disease is necessary to translate results from genetic association studies to the clinic. Assigning function to this type of variation is notoriously difficult because the human genome harbours a complex regulatory landscape with a dizzying array of transcriptional regulatory sequences, such as enhancers that have unpredictable, promiscuous and context-dependent behaviour...
December 2016: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/27808275/turning-the-tide-on-3d-nuclear-organization
#13
Peter Fraser
No abstract text is available yet for this article.
December 2016: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/27808274/organelle-dynamics-recovery-after-stress
#14
Paulina Strzyz
No abstract text is available yet for this article.
December 2016: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/27780980/genome-organization-add-a-tad-of-duplication
#15
Eytan Zlotorynski
No abstract text is available yet for this article.
December 2016: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/27780979/long-non-coding-rnas-spatial-amplifiers-that-control-nuclear-structure-and-gene-expression
#16
Jesse M Engreitz, Noah Ollikainen, Mitchell Guttman
Over the past decade, it has become clear that mammalian genomes encode thousands of long non-coding RNAs (lncRNAs), many of which are now implicated in diverse biological processes. Recent work studying the molecular mechanisms of several key examples - including Xist, which orchestrates X chromosome inactivation - has provided new insights into how lncRNAs can control cellular functions by acting in the nucleus. Here we discuss emerging mechanistic insights into how lncRNAs can regulate gene expression by coordinating regulatory proteins, localizing to target loci and shaping three-dimensional (3D) nuclear organization...
December 2016: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/27729652/nuclear-receptors-outside-the-nucleus-extranuclear-signalling-by-steroid-receptors
#17
Ellis R Levin, Stephen R Hammes
Steroid hormone receptors mediate numerous crucial biological processes and are classically thought to function as transcriptional regulators in the nucleus. However, it has been known for more than 50 years that steroids evoke rapid responses in many organs that cannot be explained by gene regulation. Mounting evidence indicates that most steroid receptors in fact exist in extranuclear cellular pools, including at the plasma membrane. This latter pool, when engaged by a steroid ligand, rapidly activates signals that affect various aspects of cellular biology...
December 2016: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/27625321/internetwork-competition-for-monomers-governs-actin-cytoskeleton-organization
#18
Cristian Suarez, David R Kovar
Cells precisely control the formation of dynamic actin cytoskeleton networks to coordinate fundamental processes, including motility, division, endocytosis and polarization. To support these functions, actin filament networks must be assembled, maintained and disassembled at the correct time and place, and with proper filament organization and dynamics. Regulation of the extent of filament network assembly and of filament network organization has been largely attributed to the coordinated activation of actin assembly factors through signalling cascades...
December 2016: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/27580841/genome-wide-mapping-and-analysis-of-chromosome-architecture
#19
Anthony D Schmitt, Ming Hu, Bing Ren
Chromosomes of eukaryotes adopt highly dynamic and complex hierarchical structures in the nucleus. The three-dimensional (3D) organization of chromosomes profoundly affects DNA replication, transcription and the repair of DNA damage. Thus, a thorough understanding of nuclear architecture is fundamental to the study of nuclear processes in eukaryotic cells. Recent years have seen rapid proliferation of technologies to investigate genome organization and function. Here, we review experimental and computational methodologies for 3D genome analysis, with special focus on recent advances in high-throughput chromatin conformation capture (3C) techniques and data analysis...
December 2016: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/27869158/mapping-the-3d-genome-aiming-for-consilience
#20
Job Dekker
The spatial organization of genomes is studied using microscopy- and chromosome conformation capture (3C)-based methods. The two types of methods produce data that are often consistent, but there are cases where they appear discordant. These cases provide opportunities to derive better models of chromatin folding, which can reconcile the datasets.
November 21, 2016: Nature Reviews. Molecular Cell Biology
journal
journal
35151
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"