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Nature Reviews. Molecular Cell Biology

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https://www.readbyqxmd.com/read/30420736/a-changing-paradigm-of-transcriptional-memory-propagation-through-mitosis
#1
REVIEW
Katherine C Palozola, Jonathan Lerner, Kenneth S Zaret
The highly reproducible inheritance of chromosomes during mitosis in mammalian cells involves nuclear envelope breakdown, increased chromatin compaction, loss of long-range intrachromosomal interactions, loss of enhancer-promoter proximity, displacement of many transcription regulators from the chromatin and a marked decrease in RNA synthesis. Despite these dramatic changes in the mother cell, daughter cells are able to faithfully re-establish the parental chromatin and gene expression features characteristic of the cell type...
November 12, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/30390028/integrative-regulation-of-physiology-by-histone-deacetylase-3
#2
REVIEW
Matthew J Emmett, Mitchell A Lazar
Cell-type-specific gene expression is physiologically modulated by the binding of transcription factors to genomic enhancer sequences, to which chromatin modifiers such as histone deacetylases (HDACs) are recruited. Drugs that inhibit HDACs are in clinical use but lack specificity. HDAC3 is a stoichiometric component of nuclear receptor co-repressor complexes whose enzymatic activity depends on this interaction. HDAC3 is required for many aspects of mammalian development and physiology, for example, for controlling metabolism and circadian rhythms...
November 2, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/30382173/inhibition-by-nuclear-cgas
#3
Grant Otto
No abstract text is available yet for this article.
October 31, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/30367118/myc-in-elongation-and-repression
#4
Eytan Zlotorynski
No abstract text is available yet for this article.
October 26, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/30341428/publisher-correction-post-transcriptional-gene-regulation-by-mrna-modifications
#5
Boxuan Simen Zhao, Ian A Roundtree, Chuan He
In Figure 5, translation initiation is promoted not by the indicated protein, but by YTHDF1 (see below).
October 19, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/30337669/preview-of-cell-cell-communication
#6
Paulina Strzyz
No abstract text is available yet for this article.
October 18, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/30337668/lipid-transfer-proteins-the-lipid-commute-via-shuttles-bridges-and-tubes
#7
REVIEW
Louise H Wong, Alberto T Gatta, Tim P Levine
Lipids are distributed in a highly heterogeneous fashion in different cellular membranes. Only a minority of lipids achieve their final intracellular distribution through transport by vesicles. Instead, the bulk of lipid traffic is mediated by a large group of lipid transfer proteins (LTPs), which move small numbers of lipids at a time using hydrophobic cavities that stabilize lipid molecules outside membranes. Although the first LTPs were discovered almost 50 years ago, most progress in understanding these proteins has been made in the past few years, leading to considerable temporal and spatial refinement of our understanding of the function of these lipid transporters...
October 18, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/30323238/actin-microtubule-crosstalk-in-cell-biology
#8
REVIEW
Marileen Dogterom, Gijsje H Koenderink
The cytoskeleton and its components - actin, microtubules and intermediate filaments - have been studied for decades, and multiple roles of the individual cytoskeletal substructures are now well established. However, in recent years it has become apparent that the three cytoskeletal elements also engage in extensive crosstalk that is important for core biological processes. Actin-microtubule crosstalk is particularly important for the regulation of cell shape and polarity during cell migration and division and the establishment of neuronal and epithelial cell shape and function...
October 15, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/30279566/-forward-genetics-and-the-causes-of-als
#9
Adriano Aguzzi
No abstract text is available yet for this article.
October 2, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/30270345/author-correction-regulation-of-microrna-biogenesis-and-its-crosstalk-with-other-cellular-pathways
#10
Thomas Treiber, Nora Treiber, Gunter Meister
In Figure 1b, the GHG sequence motif in the primary microRNA has been moved to the basal stem and the ruler of the basal stem has been shortened to more precisely delineate 11 base pairs. The changes have been made in the HTML and PDF versions of the manuscript.
September 30, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/30250295/publisher-correction-the-machineries-regulation-and-cellular-functions-of-mitochondrial-calcium
#11
Carlotta Giorgi, Saverio Marchi, Paolo Pinton
In the original version of the article, sentences highlighting references 108, 137 and 175 incorrectly refer to other items in the reference list: reference 106, 132 and 169, respectively, which were corrected - in order - to reference 110, 136 and 176. The changes have been made in the HTML and PDF versions of the manuscript.
September 24, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/30237470/a-new-era-for-understanding-amyloid-structures-and-disease
#12
REVIEW
Matthew G Iadanza, Matthew P Jackson, Eric W Hewitt, Neil A Ranson, Sheena E Radford
The aggregation of proteins into amyloid fibrils and their deposition into plaques and intracellular inclusions is the hallmark of amyloid disease. The accumulation and deposition of amyloid fibrils, collectively known as amyloidosis, is associated with many pathological conditions that can be associated with ageing, such as Alzheimer disease, Parkinson disease, type II diabetes and dialysis-related amyloidosis. However, elucidation of the atomic structure of amyloid fibrils formed from their intact protein precursors and how fibril formation relates to disease has remained elusive...
September 20, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/30228348/regulation-of-microrna-biogenesis-and-its-crosstalk-with-other-cellular-pathways
#13
REVIEW
Thomas Treiber, Nora Treiber, Gunter Meister
MicroRNAs (miRNAs) are short non-coding RNAs that inhibit the expression of target genes by directly binding to their mRNAs. miRNAs are transcribed as precursor molecules, which are subsequently cleaved by the endoribonucleases Drosha and Dicer. Mature miRNAs are bound by a member of the Argonaute (AGO) protein family to form the RNA-induced silencing complex (RISC) in a process termed RISC loading. Advances in structural analyses of Drosha and Dicer complexes enabled elucidation of the mechanisms that drive these molecular machines...
September 18, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/30228347/the-chain-terminators
#14
George G Brownlee
No abstract text is available yet for this article.
September 18, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/30224670/a-tr-checkpoint-for-s-g2-transition
#15
Michelle Trenkmann
No abstract text is available yet for this article.
September 17, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/30194414/to-degrade-or-not-to-degrade-mechanisms-and-significance-of-endocytic-recycling
#16
REVIEW
Peter J Cullen, Florian Steinberg
Newly endocytosed integral cell surface proteins are typically either directed for degradation or subjected to recycling back to the plasma membrane. The sorting of integral cell surface proteins, including signalling receptors, nutrient transporters, ion channels, adhesion molecules and polarity markers, within the endolysosomal network for recycling is increasingly recognized as an essential feature in regulating the complexities of physiology at the cell, tissue and organism levels. Historically, endocytic recycling has been regarded as a relatively passive process, where the majority of internalized integral proteins are recycled via a nonspecific sequence-independent 'bulk membrane flow' pathway...
September 7, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/30190609/one-and-one-is-not-two-taking-a-fresh-look-at-membrane-interfaces
#17
Brian Belardi, Daniel A Fletcher
No abstract text is available yet for this article.
September 6, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/30143745/the-machineries-regulation-and-cellular-functions-of-mitochondrial-calcium
#18
REVIEW
Carlotta Giorgi, Saverio Marchi, Paolo Pinton
Calcium ions (Ca2+ ) are some of the most versatile signalling molecules, and they have many physiological functions, prominently including muscle contraction, neuronal excitability, cell migration and cell growth. By sequestering and releasing Ca2+ , mitochondria serve as important regulators of cellular Ca2+ . Mitochondrial Ca2+ also has other important functions, such as regulation of mitochondrial metabolism, ATP production and cell death. In recent years, identification of the molecular machinery regulating mitochondrial Ca2+ accumulation and efflux has expanded the number of (patho)physiological conditions that rely on mitochondrial Ca2+ homeostasis...
August 24, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/30305710/linking-cellular-stress-responses-to-systemic-homeostasis
#19
REVIEW
Lorenzo Galluzzi, Takahiro Yamazaki, Guido Kroemer
Mammalian cells respond to stress by activating mechanisms that support cellular functions and hence maintain microenvironmental and organismal homeostasis. Intracellular responses to stress, their regulation and their pathophysiological implications have been extensively studied. However, little is known about the signals that emanate from stressed cells to enable a coordinated adaptive response across tissues, organs and the whole organism. Considerable evidence has now accumulated indicating that the intracellular mechanisms that are activated in response to different stresses - which include the DNA damage response, the unfolded protein response, mitochondrial stress signalling and autophagy - as well as the mechanisms ensuring the proliferative inactivation or elimination of terminally damaged cells - such as cell senescence and regulated cell death - are all coupled with the generation of signals that elicit microenvironmental and/or systemic responses...
November 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/30262892/transcriptionally-tailored-break-repair
#20
Eytan Zlotorynski
No abstract text is available yet for this article.
November 2018: Nature Reviews. Molecular Cell Biology
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