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Nature Reviews. Molecular Cell Biology

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https://www.readbyqxmd.com/read/30006559/autophagy-as-a-promoter-of-longevity-insights-from-model-organisms
#1
REVIEW
Malene Hansen, David C Rubinsztein, David W Walker
Autophagy is a conserved process that catabolizes intracellular components to maintain energy homeostasis and to protect cells against stress. Autophagy has crucial roles during development and disease, and evidence accumulated over the past decade indicates that autophagy also has a direct role in modulating ageing. In particular, elegant studies using yeasts, worms, flies and mice have demonstrated a broad requirement for autophagy-related genes in the lifespan extension observed in a number of conserved longevity paradigms...
July 13, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/29993031/concentrating-on-intrinsic-disorder
#2
Paulina Strzyz
No abstract text is available yet for this article.
July 11, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/29993030/gene-dimmer-switch
#3
Anne Mirabella
No abstract text is available yet for this article.
July 11, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/29967438/breakdancing-on-actin
#4
Paulina Strzyz
No abstract text is available yet for this article.
July 2, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/29959402/lipid-droplets-from-the-inside
#5
Kim Baumann
No abstract text is available yet for this article.
June 29, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/29946135/eukaryotic-core-promoters-and-the-functional-basis-of-transcription-initiation
#6
REVIEW
Vanja Haberle, Alexander Stark
RNA polymerase II (Pol II) core promoters are specialized DNA sequences at transcription start sites of protein-coding and non-coding genes that support the assembly of the transcription machinery and transcription initiation. They enable the highly regulated transcription of genes by selectively integrating regulatory cues from distal enhancers and their associated regulatory proteins. In this Review, we discuss the defining properties of gene core promoters, including their sequence features, chromatin architecture and transcription initiation patterns...
June 26, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/29942031/parasitic-interference
#7
Eytan Zlotorynski
No abstract text is available yet for this article.
June 25, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/29930302/regulation-of-chromatin-and-gene-expression-by-metabolic-enzymes-and-metabolites
#8
REVIEW
Xinjian Li, Gabor Egervari, Yugang Wang, Shelley L Berger, Zhimin Lu
Metabolism and gene expression, which are two fundamental biological processes that are essential to all living organisms, reciprocally regulate each other to maintain homeostasis and regulate cell growth, survival and differentiation. Metabolism feeds into the regulation of gene expression via metabolic enzymes and metabolites, which can modulate chromatin directly or indirectly - through regulation of the activity of chromatin trans-acting proteins, including histone-modifying enzymes, chromatin-remodelling complexes and transcription regulators...
June 21, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/29884834/falling-short-to-compete
#9
Paulina Strzyz
No abstract text is available yet for this article.
June 8, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/29875372/a-self-made-quiescent-niche
#10
Kim Baumann
No abstract text is available yet for this article.
June 6, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/29858606/designing-cell-function-assembly-of-synthetic-gene-circuits-for-cell-biology-applications
#11
REVIEW
Mingqi Xie, Martin Fussenegger
Synthetic biology is the discipline of engineering application-driven biological functionalities that were not evolved by nature. Early breakthroughs of cell engineering, which were based on ectopic (over)expression of single sets of transgenes, have already had a revolutionary impact on the biotechnology industry, regenerative medicine and blood transfusion therapies. Now, we require larger-scale, rationally assembled genetic circuits engineered to programme and control various human cell functions with high spatiotemporal precision in order to solve more complex problems in applied life sciences, biomedicine and environmental sciences...
June 1, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/29858605/cellular-and-epigenetic-drivers-of-stem-cell-ageing
#12
REVIEW
Maria Ermolaeva, Francesco Neri, Alessandro Ori, K Lenhard Rudolph
Adult tissue stem cells have a pivotal role in tissue maintenance and regeneration throughout the lifespan of multicellular organisms. Loss of tissue homeostasis during post-reproductive lifespan is caused, at least in part, by a decline in stem cell function and is associated with an increased incidence of diseases. Hallmarks of ageing include the accumulation of molecular damage, failure of quality control systems, metabolic changes and alterations in epigenome stability. In this Review, we discuss recent evidence in support of a novel concept whereby cell-intrinsic damage that accumulates during ageing and cell-extrinsic changes in ageing stem cell niches and the blood result in modifications of the stem cell epigenome...
June 1, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/29858604/the-functions-and-regulation-of-the-pten-tumour-suppressor-new-modes-and-prospects
#13
REVIEW
Yu-Ru Lee, Ming Chen, Pier Paolo Pandolfi
PTEN is a potent tumour suppressor, and its loss of function is frequently observed in both heritable and sporadic cancers. PTEN has phosphatase-dependent and phosphatase-independent (scaffold) activities in the cell and governs a variety of biological processes, including maintenance of genomic stability, cell survival, migration, proliferation and metabolism. Even a subtle decrease in PTEN levels and activity results in cancer susceptibility and favours tumour progression. Regulation of PTEN has therefore emerged as a subject of intense research in tumour biology...
June 1, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/29784956/dynamics-and-function-of-dna-methylation-in-plants
#14
REVIEW
Huiming Zhang, Zhaobo Lang, Jian-Kang Zhu
DNA methylation is a conserved epigenetic modification that is important for gene regulation and genome stability. Aberrant patterns of DNA methylation can lead to plant developmental abnormalities. A specific DNA methylation state is an outcome of dynamic regulation by de novo methylation, maintenance of methylation and active demethylation, which are catalysed by various enzymes that are targeted by distinct regulatory pathways. In this Review, we discuss DNA methylation in plants, including methylating and demethylating enzymes and regulatory factors, and the coordination of methylation and demethylation activities by a so-called methylstat mechanism; the functions of DNA methylation in regulating transposon silencing, gene expression and chromosome interactions; the roles of DNA methylation in plant development; and the involvement of DNA methylation in plant responses to biotic and abiotic stress conditions...
May 21, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/29769648/overcoming-obstacles-to-progression
#15
Eytan Zlotorynski
No abstract text is available yet for this article.
May 16, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/29769647/why-does-biopolymer-condensation-matter
#16
Stephen W Michnick, Louis-Philippe Bergeron-Sandoval
No abstract text is available yet for this article.
May 16, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/29765158/stepping-outside-the-comfort-zone-of-membrane-contact-site-research
#17
Maria Bohnert, Maya Schuldiner
No abstract text is available yet for this article.
May 15, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/29760421/roadblocks-and-resolutions-in-eukaryotic-translation
#18
REVIEW
Anthony P Schuller, Rachel Green
During protein synthesis, ribosomes encounter many roadblocks, the outcomes of which are largely determined by substrate availability, amino acid features and reaction kinetics. Prolonged ribosome stalling is likely to be resolved by ribosome rescue or quality control pathways, whereas shorter stalling is likely to be resolved by ongoing productive translation. How ribosome function is affected by such hindrances can therefore have a profound impact on the translational output (yield) of a particular mRNA. In this Review, we focus on these roadblocks and the resumption of normal translation elongation rather than on alternative fates wherein the stalled ribosome triggers degradation of the mRNA and the incomplete protein product...
May 14, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/29740130/publisher-correction-the-cytoplasmic-dynein-transport-machinery-and-its-many-cargoes
#19
Samara L Reck-Peterson, William B Redwine, Ronald D Vale, Andrew P Carter
In Figure 1c of the original article, ARP1 was incorrectly labelled as ARP11. The highlight for reference 37 was mistakenly placed under reference 36 and the highlight for reference 29 should have also referred to reference 16 (instead of 19). The HTML and PDF versions of the article have now been corrected.
May 8, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/29740128/publisher-correction-contextual-determinants-of-tgf%C3%AE-action-in-development-immunity-and-cancer
#20
Charles J David, Joan Massagué
In the section 'Combinatorial ligand perception' of the original article, DMP1 was incorrectly used in place of BMP. This has now been corrected in the HTML and PDF versions of the article.
May 8, 2018: Nature Reviews. Molecular Cell Biology
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