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Nature Reviews. Molecular Cell Biology

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https://www.readbyqxmd.com/read/30209310/disordered-interactions
#1
Paulina Strzyz
No abstract text is available yet for this article.
September 12, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/30194414/to-degrade-or-not-to-degrade-mechanisms-and-significance-of-endocytic-recycling
#2
REVIEW
Peter J Cullen, Florian Steinberg
Newly endocytosed integral cell surface proteins are typically either directed for degradation or subjected to recycling back to the plasma membrane. The sorting of integral cell surface proteins, including signalling receptors, nutrient transporters, ion channels, adhesion molecules and polarity markers, within the endolysosomal network for recycling is increasingly recognized as an essential feature in regulating the complexities of physiology at the cell, tissue and organism levels. Historically, endocytic recycling has been regarded as a relatively passive process, where the majority of internalized integral proteins are recycled via a nonspecific sequence-independent 'bulk membrane flow' pathway...
September 7, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/30190609/one-and-one-is-not-two-taking-a-fresh-look-at-membrane-interfaces
#3
Brian Belardi, Daniel A Fletcher
No abstract text is available yet for this article.
September 6, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/30158668/tut-tutting-retrotransposons
#4
Paulina Strzyz
No abstract text is available yet for this article.
August 29, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/30143745/the-machineries-regulation-and-cellular-functions-of-mitochondrial-calcium
#5
REVIEW
Carlotta Giorgi, Saverio Marchi, Paolo Pinton
Calcium ions (Ca2+ ) are some of the most versatile signalling molecules, and they have many physiological functions, prominently including muscle contraction, neuronal excitability, cell migration and cell growth. By sequestering and releasing Ca2+ , mitochondria serve as important regulators of cellular Ca2+ . Mitochondrial Ca2+ also has other important functions, such as regulation of mitochondrial metabolism, ATP production and cell death. In recent years, identification of the molecular machinery regulating mitochondrial Ca2+ accumulation and efflux has expanded the number of (patho)physiological conditions that rely on mitochondrial Ca2+ homeostasis...
August 24, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/30135542/not-so-crisp-r
#6
Kim Baumann
No abstract text is available yet for this article.
August 22, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/30111875/author-correction-sphingolipids-and-their-metabolism-in-physiology-and-disease
#7
Yusuf A Hannun, Lina M Obeid
In the original Figure 2, sphingolipids on the endosomal and lysosomal membranes are facing the outside of these organelles. The correct orientation of these species should be towards the lumen, as shown in the corrected figure.
August 15, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/30111874/author-correction-functional-5-utr-mrna-structures-in-eukaryotic-translation-regulation-and-how-to-find-them
#8
Kathrin Leppek, Rhiju Das, Maria Barna
The legend of Figure 1 has been modified to remove misleading referencing to evolution. The title of the legend has been modified from 'Evolutionary expansion of eukaryotic 5' UTR lengths' to 'Interspecies variation in 5' UTR lengths'; the first sentence of the legend has been modified from 'The length of 5' untranslated regions (UTRs) has increased in eukaryotes during evolution…' to 'The length of 5' untranslated regions (UTRs) varies in eukaryotes…'. The changes have been made in the HTML and PDF versions of the manuscript...
August 15, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/30111873/poly-da-dt-make-it-and-break-it
#9
Eytan Zlotorynski
No abstract text is available yet for this article.
August 15, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/30108335/regulation-of-microrna-function-in-animals
#10
REVIEW
Luca F R Gebert, Ian J MacRae
Since their serendipitous discovery in nematodes, microRNAs (miRNAs) have emerged as key regulators of biological processes in animals. These small RNAs form complex networks that regulate cell differentiation, development and homeostasis. Deregulation of miRNA function is associated with an increasing number of human diseases, particularly cancer. Recent discoveries have expanded our understanding of the control of miRNA function. Here, we review the mechanisms that modulate miRNA activity, stability and cellular localization through alternative processing and maturation, sequence editing, post-translational modifications of Argonaute proteins, viral factors, transport from the cytoplasm and regulation of miRNA-target interactions...
August 14, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/30104701/metabolites-as-regulators-of-insulin-sensitivity-and-metabolism
#11
REVIEW
Qin Yang, Archana Vijayakumar, Barbara B Kahn
The cause of insulin resistance in obesity and type 2 diabetes mellitus (T2DM) is not limited to impaired insulin signalling but also involves the complex interplay of multiple metabolic pathways. The analysis of large data sets generated by metabolomics and lipidomics has shed new light on the roles of metabolites such as lipids, amino acids and bile acids in modulating insulin sensitivity. Metabolites can regulate insulin sensitivity directly by modulating components of the insulin signalling pathway, such as insulin receptor substrates (IRSs) and AKT, and indirectly by altering the flux of substrates through multiple metabolic pathways, including lipogenesis, lipid oxidation, protein synthesis and degradation and hepatic gluconeogenesis...
August 13, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/30104700/mechanisms-of-signalling-and-biased-agonism-in-g-protein-coupled-receptors
#12
REVIEW
Denise Wootten, Arthur Christopoulos, Maria Marti-Solano, M Madan Babu, Patrick M Sexton
G protein-coupled receptors (GPCRs) are the largest group of cell surface receptors in humans that signal in response to diverse inputs and regulate a plethora of cellular processes. Hence, they constitute one of the primary drug target classes. Progress in our understanding of GPCR dynamics, activation and signalling has opened new possibilities for selective drug development. A key advancement has been provided by the concept of biased agonism, which describes the ability of ligands acting at the same GPCR to elicit distinct cellular signalling profiles by preferentially stabilizing different active conformational states of the receptor...
August 13, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/30065390/regulation-of-proteasome-assembly-and-activity-in-health-and-disease
#13
REVIEW
Adrien Rousseau, Anne Bertolotti
The proteasome degrades most cellular proteins in a controlled and tightly regulated manner and thereby controls many processes, including cell cycle, transcription, signalling, trafficking and protein quality control. Proteasomal degradation is vital in all cells and organisms, and dysfunction or failure of proteasomal degradation is associated with diverse human diseases, including cancer and neurodegeneration. Target selection is an important and well-established way to control protein degradation. In addition, mounting evidence indicates that cells adjust proteasome-mediated degradation to their needs by regulating proteasome abundance through the coordinated expression of proteasome subunits and assembly chaperones...
July 31, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/30061711/selenium-cysteine-and-epileptic-seizures
#14
Ueli Schibler
No abstract text is available yet for this article.
July 30, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/30061710/a-sugar-rush-of-dna-methylation
#15
Paulina Strzyz
No abstract text is available yet for this article.
July 30, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/30038383/translation-deregulation-in-human-disease
#16
REVIEW
Soroush Tahmasebi, Arkady Khoutorsky, Michael B Mathews, Nahum Sonenberg
Advances in sequencing and high-throughput techniques have provided an unprecedented opportunity to interrogate human diseases on a genome-wide scale. The list of disease-causing mutations is expanding rapidly, and mutations affecting mRNA translation are no exception. Translation (protein synthesis) is one of the most complex processes in the cell. The orchestrated action of ribosomes, tRNAs and numerous translation factors decodes the information contained in mRNA into a polypeptide chain. The intricate nature of this process renders it susceptible to deregulation at multiple levels...
July 23, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/30026541/arrestins-as-rheostats-of-gpcr-signalling
#17
J Silvio Gutkind, Evi Kostenis
No abstract text is available yet for this article.
July 19, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/30018342/instructive-power-of-senescence
#18
David Bernard
No abstract text is available yet for this article.
July 17, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/29993031/concentrating-on-intrinsic-disorder
#19
Paulina Strzyz
No abstract text is available yet for this article.
July 11, 2018: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/29993030/gene-dimmer-switch
#20
Anne Mirabella
No abstract text is available yet for this article.
July 11, 2018: Nature Reviews. Molecular Cell Biology
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