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Nature Reviews. Molecular Cell Biology

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https://www.readbyqxmd.com/read/28429790/ageing-is-fat-a-key-to-longevity
#1
Kim Baumann
No abstract text is available yet for this article.
April 21, 2017: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/28429789/cell-death-escrting-dying-cells-back-to-life
#2
Paulina Strzyz
No abstract text is available yet for this article.
April 21, 2017: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/28429788/the-hsp90-chaperone-machinery
#3
REVIEW
Florian H Schopf, Maximilian M Biebl, Johannes Buchner
The heat shock protein 90 (HSP90) chaperone machinery is a key regulator of proteostasis under both physiological and stress conditions in eukaryotic cells. As HSP90 has several hundred protein substrates (or 'clients'), it is involved in many cellular processes beyond protein folding, which include DNA repair, development, the immune response and neurodegenerative disease. A large number of co-chaperones interact with HSP90 and regulate the ATPase-associated conformational changes of the HSP90 dimer that occur during the processing of clients...
April 21, 2017: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/28400611/the-moment-when-translational-control-had-a-theory-of-everything
#4
Allan Jacobson
No abstract text is available yet for this article.
April 12, 2017: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/28400610/the-development-and-functions-of-multiciliated-epithelia
#5
REVIEW
Nathalie Spassky, Alice Meunier
Multiciliated cells are epithelial cells that are in contact with bodily fluids and are required for the proper function of major organs including the brain, the respiratory system and the reproductive tracts. Their multiple motile cilia beat unidirectionally to remove particles of external origin from their surface and/or drive cells or fluids into the lumen of the organs. Multiciliated cells in the brain are produced once, almost exclusively during embryonic development, whereas in respiratory tracts and oviducts they regenerate throughout life...
April 12, 2017: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/28400609/metabolism-methyl-groups-sink-into-phospholipids-and-histones
#6
Paulina Strzyz
No abstract text is available yet for this article.
April 12, 2017: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/28356571/the-mystery-of-membrane-organization-composition-regulation-and-roles-of-lipid-rafts
#7
REVIEW
Erdinc Sezgin, Ilya Levental, Satyajit Mayor, Christian Eggeling
Cellular plasma membranes are laterally heterogeneous, featuring a variety of distinct subcompartments that differ in their biophysical properties and composition. A large number of studies have focused on understanding the basis for this heterogeneity and its physiological relevance. The membrane raft hypothesis formalized a physicochemical principle for a subtype of such lateral membrane heterogeneity, in which the preferential associations between cholesterol and saturated lipids drive the formation of relatively packed (or ordered) membrane domains that selectively recruit certain lipids and proteins...
March 30, 2017: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/28293032/planar-cell-polarity-in-development-and-disease
#8
REVIEW
Mitchell T Butler, John B Wallingford
Planar cell polarity (PCP) is an essential feature of animal tissues, whereby distinct polarity is established within the plane of a cell sheet. Tissue-wide establishment of PCP is driven by multiple global cues, including gradients of gene expression, gradients of secreted WNT ligands and anisotropic tissue strain. These cues guide the dynamic, subcellular enrichment of PCP proteins, which can self-assemble into mutually exclusive complexes at opposite sides of a cell. Endocytosis, endosomal trafficking and degradation dynamics of PCP components further regulate planar tissue patterning...
March 15, 2017: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/28248323/the-code-and-beyond-transcription-regulation-by-the-rna-polymerase-ii-carboxy-terminal-domain
#9
REVIEW
Kevin M Harlen, L Stirling Churchman
The carboxy-terminal domain (CTD) extends from the largest subunit of RNA polymerase II (Pol II) as a long, repetitive and largely unstructured polypeptide chain. Throughout the transcription process, the CTD is dynamically modified by post-translational modifications, many of which facilitate or hinder the recruitment of key regulatory factors of Pol II that collectively constitute the 'CTD code'. Recent studies have revealed how the physicochemical properties of the CTD promote phase separation in the presence of other low-complexity domains...
March 1, 2017: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/28248322/global-treadmilling-coordinates-actin-turnover-and-controls-the-size-of-actin-networks
#10
REVIEW
Marie-France Carlier, Shashank Shekhar
Various cellular processes (including cell motility) are driven by the regulated, polarized assembly of actin filaments into distinct force-producing arrays of defined size and architecture. Branched, linear, contractile and cytosolic arrays coexist in vivo, and cells intricately control the number, length and assembly rate of filaments in these arrays. Recent in vitro and in vivo studies have revealed novel molecular mechanisms that regulate the number of filament barbed and pointed ends and their respective assembly and disassembly rates, thus defining classes of dynamically different filaments, which coexist in the same cell...
March 1, 2017: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/28248321/unclogging-sickle-cell-anaemia
#11
Hojun Li, Harvey Lodish
No abstract text is available yet for this article.
March 1, 2017: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/28248320/non-coding-rna-the-cancer-link-rna-between-pip3-and-akt
#12
Eytan Zlotorynski
No abstract text is available yet for this article.
March 1, 2017: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/28196981/rna-based-recognition-and-targeting-sowing-the-seeds-of-specificity
#13
REVIEW
Stanislaw A Gorski, Jörg Vogel, Jennifer A Doudna
RNA is involved in the regulation of multiple cellular processes, often by forming sequence-specific base pairs with cellular RNA or DNA targets that must be identified among the large number of nucleic acids in a cell. Several RNA-based regulatory systems in eukaryotes, bacteria and archaea, including microRNAs (miRNAs), small interfering RNAs (siRNAs), CRISPR RNAs (crRNAs) and small RNAs (sRNAs) that are dependent on the RNA chaperone protein Hfq, achieve specificity using similar strategies. Central to their function is the presentation of short 'seed sequences' within a ribonucleoprotein complex to facilitate the search for and recognition of targets...
February 15, 2017: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/28120913/mechanisms-and-functions-of-nuclear-envelope-remodelling
#14
REVIEW
Rosemarie Ungricht, Ulrike Kutay
As a compartment border, the nuclear envelope (NE) needs to serve as both a protective membrane shell for the genome and a versatile communication interface between the nucleus and the cytoplasm. Despite its important structural role in sheltering the genome, the NE is a dynamic and highly adaptable boundary that changes composition during differentiation, deforms in response to mechanical challenges, can be repaired upon rupture and even rapidly disassembles and reforms during open mitosis. NE remodelling is fundamentally involved in cell growth, division and differentiation, and if perturbed can lead to devastating diseases such as muscular dystrophies or premature ageing...
January 25, 2017: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/28377621/cell-senescence-a-new-role-for-atm
#15
Paulina Strzyz
No abstract text is available yet for this article.
May 2017: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/28377620/epigenetics-cytosolic-ezh1-muscles-prc2-out-of-the-nucleus
#16
Eytan Zlotorynski
No abstract text is available yet for this article.
May 2017: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/28377619/lipid-metabolism-cholesterol-feeds-into-cell-growth-control
#17
Paulina Strzyz
No abstract text is available yet for this article.
May 2017: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/28377618/stress-responses-membrane-to-nucleus-signals-modulate-plant-cold-tolerance
#18
Kim Baumann
No abstract text is available yet for this article.
May 2017: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/28377617/dna-damage-response-rna-m-6-a-regulates-dna-repair
#19
Eytan Zlotorynski
No abstract text is available yet for this article.
May 2017: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/28356573/plant-cell-development-forcing-cell-polarity
#20
Paulina Strzyz
No abstract text is available yet for this article.
May 2017: Nature Reviews. Molecular Cell Biology
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