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Nature Reviews. Neuroscience

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https://www.readbyqxmd.com/read/28592903/learning-and-memory-when-novel-becomes-familiar
#1
Sian Lewis
No abstract text is available yet for this article.
June 8, 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28515433/the-sleep-deprived-human-brain
#2
REVIEW
Adam J Krause, Eti Ben Simon, Bryce A Mander, Stephanie M Greer, Jared M Saletin, Andrea N Goldstein-Piekarski, Matthew P Walker
How does a lack of sleep affect our brains? In contrast to the benefits of sleep, frameworks exploring the impact of sleep loss are relatively lacking. Importantly, the effects of sleep deprivation (SD) do not simply reflect the absence of sleep and the benefits attributed to it; rather, they reflect the consequences of several additional factors, including extended wakefulness. With a focus on neuroimaging studies, we review the consequences of SD on attention and working memory, positive and negative emotion, and hippocampal learning...
May 18, 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28490777/working-memory-keeping-short-term-memories-alive
#3
Natasha Bray
No abstract text is available yet for this article.
May 11, 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28592905/functional-consequences-of-neuropeptide-and-small-molecule-co-transmission
#4
REVIEW
Michael P Nusbaum, Dawn M Blitz, Eve Marder
Colocalization of small-molecule and neuropeptide transmitters is common throughout the nervous system of all animals. The resulting co-transmission, which provides conjoint ionotropic ('classical') and metabotropic ('modulatory') actions, includes neuropeptide- specific aspects that are qualitatively different from those that result from metabotropic actions of small-molecule transmitter release. Here, we focus on the flexibility afforded to microcircuits by such co-transmission, using examples from various nervous systems...
July 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28592904/non-motor-features-of-parkinson-disease
#5
REVIEW
Anthony H V Schapira, K Ray Chaudhuri, Peter Jenner
Many of the motor symptoms of Parkinson disease (PD) can be preceded, sometimes for several years, by non-motor symptoms that include hyposmia, sleep disorders, depression and constipation. These non-motor features appear across the spectrum of patients with PD, including individuals with genetic causes of PD. The neuroanatomical and neuropharmacological bases of non-motor abnormalities in PD remain largely undefined. Here, we discuss recent advances that have helped to establish the presence, severity and effect on the quality of life of non-motor symptoms in PD, and the neuroanatomical and neuropharmacological mechanisms involved...
July 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28541348/neuron-glia-interactions-waking-the-synapse
#6
Katherine Whalley
No abstract text is available yet for this article.
July 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28541347/working-memory-persistence-is-key
#7
Natasha Bray
No abstract text is available yet for this article.
July 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28515434/cerebral-blood-flow-regulation-and-neurovascular-dysfunction-in-alzheimer-disease
#8
REVIEW
Kassandra Kisler, Amy R Nelson, Axel Montagne, Berislav V Zlokovic
Cerebral blood flow (CBF) regulation is essential for normal brain function. The mammalian brain has evolved a unique mechanism for CBF control known as neurovascular coupling. This mechanism ensures a rapid increase in the rate of CBF and oxygen delivery to activated brain structures. The neurovascular unit is composed of astrocytes, mural vascular smooth muscle cells and pericytes, and endothelia, and regulates neurovascular coupling. This Review article examines the cellular and molecular mechanisms within the neurovascular unit that contribute to CBF control, and neurovascular dysfunction in neurodegenerative disorders such as Alzheimer disease...
July 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28626229/linking-social-context-and-addiction-neuroscience-a-computational-psychiatry-approach
#9
Andrea Reiter, Andreas Heinz, Lorenz Deserno
No abstract text is available yet for this article.
June 19, 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28626228/neurodevelopmental-disorders-taking-on-fxs-with-a-diabetes-drug
#10
Darran Yates
No abstract text is available yet for this article.
June 19, 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28626227/neural-circuits-an-angle-on-navigation
#11
Darran Yates
No abstract text is available yet for this article.
June 19, 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28626226/sleep-labelling-sleep-generators
#12
Darran Yates
No abstract text is available yet for this article.
June 19, 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28626225/neurodevelopment-organizing-the-second-brain
#13
Darran Yates
No abstract text is available yet for this article.
June 19, 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28490778/brain-ageing-a-youthful-reminder
#14
Darran Yates
No abstract text is available yet for this article.
June 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28490776/learning-and-memory-consolidation-circuitry
#15
Darran Yates
No abstract text is available yet for this article.
June 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28469276/adult-hippocampal-neurogenesis-and-cognitive-flexibility-linking-memory-and-mood
#16
REVIEW
Christoph Anacker, René Hen
Adult hippocampal neurogenesis has been implicated in cognitive processes, such as pattern separation, and in the behavioural effects of stress and antidepressants. Young adult-born neurons have been shown to inhibit the overall activity of the dentate gyrus by recruiting local interneurons, which may result in sparse contextual representations and improved pattern separation. We propose that neurogenesis-mediated inhibition also reduces memory interference and enables reversal learning both in neutral situations and in emotionally charged ones...
June 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28446787/neural-development-keeping-a-lid-on-alternative-fates
#17
Katherine Whalley
No abstract text is available yet for this article.
June 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28446786/how-and-why-do-t-cells-and-their-derived-cytokines-affect-the-injured-and-healthy-brain
#18
REVIEW
Anthony J Filiano, Sachin P Gadani, Jonathan Kipnis
The evolution of adaptive immunity provides enhanced defence against specific pathogens, as well as homeostatic immune surveillance of all tissues. Despite being 'immune privileged', the CNS uses the assistance of the immune system in physiological and pathological states. In this Opinion article, we discuss the influence of adaptive immunity on recovery after CNS injury and on cognitive and social brain function. We further extend a hypothesis that the pro-social effects of interferon-regulated genes were initially exploited by pathogens to increase host-host transmission, and that these genes were later recycled by the host to form part of an immune defence programme...
June 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28435164/navigation-sounds-like-non-spatial-navigation
#19
Natasha Bray
No abstract text is available yet for this article.
June 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28435163/progranulin-lysosomal-regulation-and-neurodegenerative-disease
#20
REVIEW
Aimee W Kao, Andrew McKay, Param Priya Singh, Anne Brunet, Eric J Huang
The discovery that heterozygous and homozygous mutations in the gene encoding progranulin are causally linked to frontotemporal dementia and lysosomal storage disease, respectively, reveals previously unrecognized roles of the progranulin protein in regulating lysosome biogenesis and function. Given the importance of lysosomes in cellular homeostasis, it is not surprising that progranulin deficiency has pleiotropic effects on neural circuit development and maintenance, stress response, innate immunity and ageing...
June 2017: Nature Reviews. Neuroscience
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