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Nature Reviews. Neuroscience

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https://www.readbyqxmd.com/read/30209325/receptor-replacement
#1
Darran Yates
No abstract text is available yet for this article.
September 12, 2018: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/30206330/inflammasome-signalling-in-brain-function-and-neurodegenerative-disease
#2
REVIEW
Michael T Heneka, Róisín M McManus, Eicke Latz
The mammalian CNS is an intricate and fragile structure, which on one hand is open to change in order to store information, but on the other hand is vulnerable to damage from injury, pathogen invasion or neurodegeneration. During senescence and neurodegeneration, activation of the innate immune system can occur. Inflammasomes are signalling complexes that regulate cells of the immune system, which in the brain mainly includes microglial cells. In microglia, the NLRP3 (NOD-, LRR- and pyrin domain-containing 3) inflammasome becomes activated when these cells sense proteins such as misfolded or aggregated amyloid-β, α-synuclein and prion protein or superoxide dismutase, ATP and members of the complement pathway...
September 11, 2018: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/30206329/untangling-tau-structure
#3
Sian Lewis
No abstract text is available yet for this article.
September 11, 2018: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/30206328/microglial-signatures-and-their-role-in-health-and-disease
#4
REVIEW
Oleg Butovsky, Howard L Weiner
Microglia are the primary innate immune cells in the CNS. In the healthy brain, they exhibit a unique molecular homeostatic 'signature', consisting of a specific transcriptional profile and surface protein expression pattern, which differs from that of tissue macrophages. In recent years, there have been a number of important advances in our understanding of the molecular signatures of homeostatic microglia and disease-associated microglia that have provided insight into how these cells are regulated in health and disease and how they contribute to the maintenance of the neural environment...
September 11, 2018: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/30206327/novel-inhibition
#5
Sian Lewis
No abstract text is available yet for this article.
September 11, 2018: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/30206326/planning-a-path
#6
Sian Lewis
No abstract text is available yet for this article.
September 11, 2018: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/30206325/catching-waves
#7
Sian Lewis
No abstract text is available yet for this article.
September 11, 2018: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/30194347/rodent-models-for-alzheimer-disease
#8
REVIEW
Jürgen Götz, Liviu-Gabriel Bodea, Michel Goedert
Animal models are indispensable tools for Alzheimer disease (AD) research. Over the course of more than two decades, an increasing number of complementary rodent models has been generated. These models have facilitated testing hypotheses about the aetiology and progression of AD, dissecting the associated pathomechanisms and validating therapeutic interventions, thereby providing guidance for the design of human clinical trials. However, the lack of success in translating rodent data into therapeutic outcomes may challenge the validity of the current models...
September 7, 2018: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/30158590/multiple-sclerosis-and-cognition-synaptic-failure-and-network-dysfunction
#9
REVIEW
Massimiliano Di Filippo, Emilio Portaccio, Andrea Mancini, Paolo Calabresi
Cognitive impairment is increasingly recognized to be a core feature of multiple sclerosis (MS), with important implications for the everyday life of individuals with MS and for disease management. Unfortunately, the exact mechanisms that underlie this cognitive impairment are poorly understood and there are no effective therapeutic options for this aspect of the disease. During MS, focal brain inflammatory lesions, together with pathological changes of both CNS grey matter and normal-appearing white matter, can interfere with cognitive functions...
August 29, 2018: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/30154508/concentrating-on-the-claustrum
#10
Natasha Bray
No abstract text is available yet for this article.
August 28, 2018: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/30111776/auditory-advances
#11
Katherine Whalley
No abstract text is available yet for this article.
August 15, 2018: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/30108301/reply-to-can-neocortical-feedback-alter-the-sign-of-plasticity
#12
LETTER
Pieter R Roelfsema, Anthony Holtmaat
No abstract text is available yet for this article.
August 14, 2018: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/30108300/can-neocortical-feedback-alter-the-sign-of-plasticity
#13
LETTER
Blake A Richards, Timothy P Lillicrap
No abstract text is available yet for this article.
August 14, 2018: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/30002509/on-the-nature-and-use-of-models-in-network-neuroscience
#14
REVIEW
Danielle S Bassett, Perry Zurn, Joshua I Gold
Network theory provides an intuitively appealing framework for studying relationships among interconnected brain mechanisms and their relevance to behaviour. As the space of its applications grows, so does the diversity of meanings of the term network model. This diversity can cause confusion, complicate efforts to assess model validity and efficacy, and hamper interdisciplinary collaboration. In this Review, we examine the field of network neuroscience, focusing on organizing principles that can help overcome these challenges...
July 12, 2018: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/29991695/converging-inputs
#15
Darran Yates
No abstract text is available yet for this article.
July 10, 2018: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/29991694/treasure-hunt
#16
Sian Lewis
No abstract text is available yet for this article.
July 10, 2018: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/29934562/losing-sleep-over-lipids
#17
Natasha Bray
No abstract text is available yet for this article.
June 22, 2018: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/29934560/trading-places
#18
Sian Lewis
No abstract text is available yet for this article.
June 22, 2018: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/30089889/hands-of-cell-fate
#19
Sian Lewis
No abstract text is available yet for this article.
September 2018: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/30089888/decision-making-in-sensorimotor-control
#20
REVIEW
Jason P Gallivan, Craig S Chapman, Daniel M Wolpert, J Randall Flanagan
Skilled sensorimotor interactions with the world result from a series of decision-making processes that determine, on the basis of information extracted during the unfolding sequence of events, which movements to make and when and how to make them. Despite this inherent link between decision-making and sensorimotor control, research into each of these two areas has largely evolved in isolation, and it is only fairly recently that researchers have begun investigating how they interact and, together, influence behaviour...
September 2018: Nature Reviews. Neuroscience
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