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Nature Reviews. Neuroscience

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https://www.readbyqxmd.com/read/28541348/neuron-glia-interactions-waking-the-synapse
#1
Katherine Whalley
No abstract text is available yet for this article.
May 25, 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28541347/working-memory-persistence-is-key
#2
Natasha Bray
No abstract text is available yet for this article.
May 25, 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28515434/cerebral-blood-flow-regulation-and-neurovascular-dysfunction-in-alzheimer-disease
#3
REVIEW
Kassandra Kisler, Amy R Nelson, Axel Montagne, Berislav V Zlokovic
Cerebral blood flow (CBF) regulation is essential for normal brain function. The mammalian brain has evolved a unique mechanism for CBF control known as neurovascular coupling. This mechanism ensures a rapid increase in the rate of CBF and oxygen delivery to activated brain structures. The neurovascular unit is composed of astrocytes, mural vascular smooth muscle cells and pericytes, and endothelia, and regulates neurovascular coupling. This Review article examines the cellular and molecular mechanisms within the neurovascular unit that contribute to CBF control, and neurovascular dysfunction in neurodegenerative disorders such as Alzheimer disease...
May 18, 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28515433/the-sleep-deprived-human-brain
#4
REVIEW
Adam J Krause, Eti Ben Simon, Bryce A Mander, Stephanie M Greer, Jared M Saletin, Andrea N Goldstein-Piekarski, Matthew P Walker
How does a lack of sleep affect our brains? In contrast to the benefits of sleep, frameworks exploring the impact of sleep loss are relatively lacking. Importantly, the effects of sleep deprivation (SD) do not simply reflect the absence of sleep and the benefits attributed to it; rather, they reflect the consequences of several additional factors, including extended wakefulness. With a focus on neuroimaging studies, we review the consequences of SD on attention and working memory, positive and negative emotion, and hippocampal learning...
May 18, 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28490777/working-memory-keeping-short-term-memories-alive
#5
Natasha Bray
No abstract text is available yet for this article.
May 11, 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28490778/brain-ageing-a-youthful-reminder
#6
Darran Yates
No abstract text is available yet for this article.
June 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28490776/learning-and-memory-consolidation-circuitry
#7
Darran Yates
No abstract text is available yet for this article.
June 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28469276/adult-hippocampal-neurogenesis-and-cognitive-flexibility-linking-memory-and-mood
#8
REVIEW
Christoph Anacker, René Hen
Adult hippocampal neurogenesis has been implicated in cognitive processes, such as pattern separation, and in the behavioural effects of stress and antidepressants. Young adult-born neurons have been shown to inhibit the overall activity of the dentate gyrus by recruiting local interneurons, which may result in sparse contextual representations and improved pattern separation. We propose that neurogenesis-mediated inhibition also reduces memory interference and enables reversal learning both in neutral situations and in emotionally charged ones...
June 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28446787/neural-development-keeping-a-lid-on-alternative-fates
#9
Katherine Whalley
No abstract text is available yet for this article.
June 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28446786/how-and-why-do-t-cells-and-their-derived-cytokines-affect-the-injured-and-healthy-brain
#10
REVIEW
Anthony J Filiano, Sachin P Gadani, Jonathan Kipnis
The evolution of adaptive immunity provides enhanced defence against specific pathogens, as well as homeostatic immune surveillance of all tissues. Despite being 'immune privileged', the CNS uses the assistance of the immune system in physiological and pathological states. In this Opinion article, we discuss the influence of adaptive immunity on recovery after CNS injury and on cognitive and social brain function. We further extend a hypothesis that the pro-social effects of interferon-regulated genes were initially exploited by pathogens to increase host-host transmission, and that these genes were later recycled by the host to form part of an immune defence programme...
June 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28435164/navigation-sounds-like-non-spatial-navigation
#11
Natasha Bray
No abstract text is available yet for this article.
June 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28435163/progranulin-lysosomal-regulation-and-neurodegenerative-disease
#12
REVIEW
Aimee W Kao, Andrew McKay, Param Priya Singh, Anne Brunet, Eric J Huang
The discovery that heterozygous and homozygous mutations in the gene encoding progranulin are causally linked to frontotemporal dementia and lysosomal storage disease, respectively, reveals previously unrecognized roles of the progranulin protein in regulating lysosome biogenesis and function. Given the importance of lysosomes in cellular homeostasis, it is not surprising that progranulin deficiency has pleiotropic effects on neural circuit development and maintenance, stress response, innate immunity and ageing...
June 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28515493/sleep-dream-a-little-dream
#13
Sian Lewis
No abstract text is available yet for this article.
May 18, 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28515492/the-brain-sirtuins-and-ageing
#14
REVIEW
Akiko Satoh, Shin-Ichiro Imai, Leonard Guarente
In mammals, recent studies have demonstrated that the brain, the hypothalamus in particular, is a key bidirectional integrator of humoral and neural information from peripheral tissues, thus influencing ageing both in the brain and at the 'systemic' level. CNS decline drives the progressive impairment of cognitive, social and physical abilities, and the mechanisms underlying CNS regulation of the ageing process, such as microglia-neuron networks and the activities of sirtuins, a class of NAD(+)-dependent deacylases, are beginning to be understood...
May 18, 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28515491/the-emerging-field-of-epigenetics-in-neurodegeneration-and-neuroprotection
#15
REVIEW
Jee-Yeon Hwang, Kelly A Aromolaran, R Suzanne Zukin
Epigenetic mechanisms - including DNA methylation, histone post-translational modifications and changes in nucleosome positioning - regulate gene expression, cellular differentiation and development in almost all tissues, including the brain. In adulthood, changes in the epigenome are crucial for higher cognitive functions such as learning and memory. Striking new evidence implicates the dysregulation of epigenetic mechanisms in neurodegenerative disorders and diseases. Although these disorders differ in their underlying causes and pathophysiologies, many involve the dysregulation of restrictive element 1-silencing transcription factor (REST), which acts via epigenetic mechanisms to regulate gene expression...
May 18, 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28515490/neuronal-development-the-source-of-the-signal
#16
Sian Lewis
No abstract text is available yet for this article.
May 18, 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28515489/brain-evolution-genetic-layering
#17
Sian Lewis
No abstract text is available yet for this article.
May 18, 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28515488/learning-and-memory-a-state-to-remember
#18
Sian Lewis
No abstract text is available yet for this article.
May 18, 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28381834/cerebellum-the-little-learning-brain
#19
Natasha Bray
No abstract text is available yet for this article.
May 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28381833/genetic-and-activity-dependent-mechanisms-underlying-interneuron-diversity
#20
REVIEW
Brie Wamsley, Gord Fishell
The proper construction of neural circuits requires the generation of diverse cell types, their distribution to defined regions, and their specific and appropriate wiring. A major objective in neurobiology has been to understand the molecular determinants that link neural birth to terminal specification and functional connectivity, a task that is especially daunting in the case of cortical interneurons. Considerable evidence supports the idea that an interplay of intrinsic and environmental signalling is crucial to the sequential steps of interneuron specification, including migration, selection of a settling position, morphogenesis and synaptogenesis...
May 2017: Nature Reviews. Neuroscience
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