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Nature Reviews. Genetics

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https://www.readbyqxmd.com/read/28239157/non-coding-rna-exosomal-micrornas-as-novel-adipokines
#1
Claire Greenhill
No abstract text is available yet for this article.
February 27, 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28239156/cancer-genomics-ecdetect-hunts-extrachromosomal-dna
#2
Shimona Starling
No abstract text is available yet for this article.
February 27, 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28216634/detecting-rna-modifications-in-the-epitranscriptome-predict-and-validate
#3
REVIEW
Mark Helm, Yuri Motorin
RNA modifications are emerging players in the field of post-transcriptional regulation of gene expression, and are attracting a comparable degree of research interest to DNA and histone modifications in the field of epigenetics. We now know of more than 150 RNA modifications and the true potential of a few of these is currently emerging as the consequence of a leap in detection technology, principally associated with high-throughput sequencing. This Review outlines the major developments in this field through a structured discussion of detection principles, lays out advantages and drawbacks of new high-throughput methods and presents conventional biophysical identification of modifications as meaningful ways for validation...
February 20, 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28190876/the-evolution-of-tumour-phylogenetics-principles-and-practice
#4
REVIEW
Russell Schwartz, Alejandro A Schäffer
Rapid advances in high-throughput sequencing and a growing realization of the importance of evolutionary theory to cancer genomics have led to a proliferation of phylogenetic studies of tumour progression. These studies have yielded not only new insights but also a plethora of experimental approaches, sometimes reaching conflicting or poorly supported conclusions. Here, we consider this body of work in light of the key computational principles underpinning phylogenetic inference, with the goal of providing practical guidance on the design and analysis of scientifically rigorous tumour phylogeny studies...
February 13, 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28190875/technique-barcoding-the-nucleus
#5
Dorothy Clyde
No abstract text is available yet for this article.
February 13, 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28163321/limb-development-a-paradigm-of-gene-regulation
#6
REVIEW
Florence Petit, Karen E Sears, Nadav Ahituv
The limb is a commonly used model system for developmental biology. Given the need for precise control of complex signalling pathways to achieve proper patterning, the limb is also becoming a model system for gene regulation studies. Recent developments in genomic technologies have enabled the genome-wide identification of regulatory elements that control limb development, yielding insights into the determination of limb morphology and forelimb versus hindlimb identity. The modulation of regulatory interactions - for example, through the modification of regulatory sequences or chromatin architecture - can lead to morphological evolution, acquired regeneration capacity or limb malformations in diverse species, including humans...
February 6, 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28163320/complex-traits-selecting-against-schooling
#7
Kirsty Minton
No abstract text is available yet for this article.
February 6, 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28138144/chromatin-dynamics-during-the-cell-cycle-at-centromeres
#8
REVIEW
Sebastian Müller, Geneviève Almouzni
Centromeric chromatin undergoes major changes in composition and architecture during each cell cycle. These changes in specialized chromatin facilitate kinetochore formation in mitosis to ensure proper chromosome segregation. Thus, proper orchestration of centromeric chromatin dynamics during interphase, including replication in S phase, is crucial. We provide the current view concerning the centromeric architecture associated with satellite repeat sequences in mammals and its dynamics during the cell cycle...
January 31, 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28138143/evolving-health-care-through-personal-genomics
#9
REVIEW
Heidi L Rehm
With the rapid evolution of next-generation DNA sequencing technologies, the cost of sequencing a human genome has plummeted, and genomics has started to pervade health care across all stages of life - from preconception to adult medicine. Challenges to fully embracing genomics in a clinical setting remain, but some approaches are starting to overcome these barriers, such as community-driven data sharing to improve the accuracy and efficiency of applying genomics to patient care.
January 31, 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28111472/building-a-lineage-from-single-cells-genetic-techniques-for-cell-lineage-tracking
#10
REVIEW
Mollie B Woodworth, Kelly M Girskis, Christopher A Walsh
Resolving lineage relationships between cells in an organism is a fundamental interest of developmental biology. Furthermore, investigating lineage can drive understanding of pathological states, including cancer, as well as understanding of developmental pathways that are amenable to manipulation by directed differentiation. Although lineage tracking through the injection of retroviral libraries has long been the state of the art, a recent explosion of methodological advances in exogenous labelling and single-cell sequencing have enabled lineage tracking at larger scales, in more detail, and in a wider range of species than was previously considered possible...
January 23, 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28111470/metagenomics-uncultivated-microbes-reveal-new-crispr-cas-systems
#11
Ross Cloney
No abstract text is available yet for this article.
January 23, 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/27990019/transcriptional-architecture-of-the-mammalian-circadian-clock
#12
REVIEW
Joseph S Takahashi
Circadian clocks are endogenous oscillators that control 24-hour physiological and behavioural processes in organisms. These cell-autonomous clocks are composed of a transcription-translation-based autoregulatory feedback loop. With the development of next-generation sequencing approaches, biochemical and genomic insights into circadian function have recently come into focus. Genome-wide analyses of the clock transcriptional feedback loop have revealed a global circadian regulation of processes such as transcription factor occupancy, RNA polymerase II recruitment and initiation, nascent transcription, and chromatin remodelling...
December 19, 2016: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28138147/non-coding-rna-pri-mirna-processing-structure-is-key
#13
Louise Adams
No abstract text is available yet for this article.
March 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28138146/technique-smile-seq-illuminates-transcription-factor-motifs
#14
Shimona Starling
No abstract text is available yet for this article.
March 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28138145/genetic-variation-giving-context-to-phenotype-prediction
#15
Ross Cloney
No abstract text is available yet for this article.
March 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28111471/cancer-genomics-keeping-score-with-immunotherapy-response
#16
Dorothy Clyde
No abstract text is available yet for this article.
March 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28045100/ground-rules-of-the-pluripotency-gene-regulatory-network
#17
REVIEW
Mo Li, Juan Carlos Izpisua Belmonte
Pluripotency is a state that exists transiently in the early embryo and, remarkably, can be recapitulated in vitro by deriving embryonic stem cells or by reprogramming somatic cells to become induced pluripotent stem cells. The state of pluripotency, which is stabilized by an interconnected network of pluripotency-associated genes, integrates external signals and exerts control over the decision between self-renewal and differentiation at the transcriptional, post-transcriptional and epigenetic levels. Recent evidence of alternative pluripotency states indicates the regulatory flexibility of this network...
March 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28029161/down-syndrome-and-the-complexity-of-genome-dosage-imbalance
#18
REVIEW
Stylianos E Antonarakis
Down syndrome (also known as trisomy 21) is the model human phenotype for all genomic gain dosage imbalances, including microduplications. The functional genomic exploration of the post-sequencing years of chromosome 21, and the generation of numerous cellular and mouse models, have provided an unprecedented opportunity to decipher the molecular consequences of genome dosage imbalance. Studies of Down syndrome could provide knowledge far beyond the well-known characteristics of intellectual disability and dysmorphic features, as several other important features, including congenital heart defects, early ageing, Alzheimer disease and childhood leukaemia, are also part of the Down syndrome phenotypic spectrum...
March 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28196982/gene-expression-host-pathogen-duels-revealed-by-dual-rna-seq-in-vivo
#19
Darren J Burgess
No abstract text is available yet for this article.
February 15, 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28045101/functional-genomics-screening-for-lncrna-function
#20
Linda Koch
No abstract text is available yet for this article.
February 2017: Nature Reviews. Genetics
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