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Nature Reviews. Genetics

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https://www.readbyqxmd.com/read/28420879/evolutionary-genetics-fantastic-beasts-cephalopod-rna-recoding
#1
Shimona Starling
No abstract text is available yet for this article.
April 19, 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28392571/scaling-by-shrinking-empowering-single-cell-omics-with-microfluidic-devices
#2
REVIEW
Sanjay M Prakadan, Alex K Shalek, David A Weitz
Recent advances in cellular profiling have demonstrated substantial heterogeneity in the behaviour of cells once deemed 'identical', challenging fundamental notions of cell 'type' and 'state'. Not surprisingly, these findings have elicited substantial interest in deeply characterizing the diversity, interrelationships and plasticity among cellular phenotypes. To explore these questions, experimental platforms are needed that can extensively and controllably profile many individual cells. Here, microfluidic structures - whether valve-, droplet- or nanowell-based - have an important role because they can facilitate easy capture and processing of single cells and their components, reducing labour and costs relative to conventional plate-based methods while also improving consistency...
April 10, 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28344341/functional-variomics-and-network-perturbation-connecting-genotype-to-phenotype-in-cancer
#3
REVIEW
Song Yi, Shengda Lin, Yongsheng Li, Wei Zhao, Gordon B Mills, Nidhi Sahni
Proteins interact with other macromolecules in complex cellular networks for signal transduction and biological function. In cancer, genetic aberrations have been traditionally thought to disrupt the entire gene function. It has been increasingly appreciated that each mutation of a gene could have a subtle but unique effect on protein function or network rewiring, contributing to diverse phenotypic consequences across cancer patient populations. In this Review, we discuss the current understanding of cancer genetic variants, including the broad spectrum of mutation classes and the wide range of mechanistic effects on gene function in the context of signalling networks...
March 27, 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28286336/genetics-of-coronary-artery-disease-discovery-biology-and-clinical-translation
#4
REVIEW
Amit V Khera, Sekar Kathiresan
Coronary artery disease is the leading global cause of mortality. Long recognized to be heritable, recent advances have started to unravel the genetic architecture of the disease. Common variant association studies have linked approximately 60 genetic loci to coronary risk. Large-scale gene sequencing efforts and functional studies have facilitated a better understanding of causal risk factors, elucidated underlying biology and informed the development of new therapeutics. Moving forwards, genetic testing could enable precision medicine approaches by identifying subgroups of patients at increased risk of coronary artery disease or those with a specific driving pathophysiology in whom a therapeutic or preventive approach would be most useful...
March 13, 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28260791/autism-genetics-opportunities-and-challenges-for-clinical-translation
#5
REVIEW
Jacob A S Vorstman, Jeremy R Parr, Daniel Moreno-De-Luca, Richard J L Anney, John I Nurnberger, Joachim F Hallmayer
Genetic studies have revealed the involvement of hundreds of gene variants in autism. Their risk effects are highly variable, and they are frequently related to other conditions besides autism. However, many different variants converge on common biological pathways. These findings indicate that aetiological heterogeneity, variable penetrance and genetic pleiotropy are pervasive characteristics of autism genetics. Although this advancing insight should improve clinical care, at present there is a substantial discrepancy between research knowledge and its clinical application...
March 6, 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28366938/genetic-variation-linear-insights-into-non-coding-dna
#6
Shimona Starling
No abstract text is available yet for this article.
May 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28366937/genetic-screens-crispr-based-mapping-of-genetic-interactions
#7
Ross Cloney
No abstract text is available yet for this article.
May 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28366936/rna-translated-circular-rnas
#8
Linda Koch
No abstract text is available yet for this article.
May 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28344343/genome-organization-zooming-in-on-nuclear-organization
#9
Katharine H Wrighton
No abstract text is available yet for this article.
May 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28344342/disease-genomics-transitioning-from-association-to-causation-with-eqtls
#10
Dorothy Clyde
No abstract text is available yet for this article.
May 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28344340/regulatory-elements-a-boost-to-rna-processing
#11
Linda Koch
No abstract text is available yet for this article.
May 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28286338/integration-site-selection-by-retroviruses-and-transposable-elements-in-eukaryotes
#12
REVIEW
Tania Sultana, Alessia Zamborlini, Gael Cristofari, Pascale Lesage
Transposable elements and retroviruses are found in most genomes, can be pathogenic and are widely used as gene-delivery and functional genomics tools. Exploring whether these genetic elements target specific genomic sites for integration and how this preference is achieved is crucial to our understanding of genome evolution, somatic genome plasticity in cancer and ageing, host-parasite interactions and genome engineering applications. High-throughput profiling of integration sites by next-generation sequencing, combined with large-scale genomic data mining and cellular or biochemical approaches, has revealed that the insertions are usually non-random...
May 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28286337/transplant-genetics-and-genomics
#13
REVIEW
Joshua Y C Yang, Minnie M Sarwal
Ever since the discovery of the major histocompatibility complex, scientific and clinical understanding in the field of transplantation has been advanced through genetic and genomic studies. Candidate-gene approaches and recent genome-wide association studies (GWAS) have enabled a deeper understanding of the complex interplay of the donor-recipient interactions that lead to transplant tolerance or rejection. Genetic analysis in transplantation, when linked to demographic and clinical outcomes, has the potential to drive personalized medicine by enabling individualized risk stratification and immunosuppression through the identification of variants associated with immune-mediated complications, post-transplant disease or alterations in drug-metabolizing genes...
May 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28216634/detecting-rna-modifications-in-the-epitranscriptome-predict-and-validate
#14
REVIEW
Mark Helm, Yuri Motorin
RNA modifications are emerging players in the field of post-transcriptional regulation of gene expression, and are attracting a comparable degree of research interest to DNA and histone modifications in the field of epigenetics. We now know of more than 150 RNA modifications and the true potential of a few of these is currently emerging as the consequence of a leap in detection technology, principally associated with high-throughput sequencing. This Review outlines the major developments in this field through a structured discussion of detection principles, lays out advantages and drawbacks of new high-throughput methods and presents conventional biophysical identification of modifications as meaningful ways for validation...
May 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28400600/synthetic-biology-building-a-custom-eukaryotic-genome-de-novo
#15
Darren J Burgess
No abstract text is available yet for this article.
April 12, 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28400601/gene-regulation-the-nuclear-pore-a-scaffold-for-inducible-genes
#16
Shimona Starling
No abstract text is available yet for this article.
April 10, 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28239157/non-coding-rna-exosomal-micrornas-as-novel-adipokines
#17
Claire Greenhill
No abstract text is available yet for this article.
April 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28239156/cancer-genomics-ecdetect-hunts-extrachromosomal-dna
#18
Shimona Starling
No abstract text is available yet for this article.
April 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28190876/the-evolution-of-tumour-phylogenetics-principles-and-practice
#19
REVIEW
Russell Schwartz, Alejandro A Schäffer
Rapid advances in high-throughput sequencing and a growing realization of the importance of evolutionary theory to cancer genomics have led to a proliferation of phylogenetic studies of tumour progression. These studies have yielded not only new insights but also a plethora of experimental approaches, sometimes reaching conflicting or poorly supported conclusions. Here, we consider this body of work in light of the key computational principles underpinning phylogenetic inference, with the goal of providing practical guidance on the design and analysis of scientifically rigorous tumour phylogeny studies...
April 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28190875/technique-barcoding-the-nucleus
#20
Dorothy Clyde
No abstract text is available yet for this article.
April 2017: Nature Reviews. Genetics
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