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Nature Reviews. Genetics

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https://www.readbyqxmd.com/read/28045101/functional-genomics-screening-for-lncrna-function
#1
Linda Koch
No abstract text is available yet for this article.
January 3, 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28045100/ground-rules-of-the-pluripotency-gene-regulatory-network
#2
Mo Li, Juan Carlos Izpisua Belmonte
Pluripotency is a state that exists transiently in the early embryo and, remarkably, can be recapitulated in vitro by deriving embryonic stem cells or by reprogramming somatic cells to become induced pluripotent stem cells. The state of pluripotency, which is stabilized by an interconnected network of pluripotency-associated genes, integrates external signals and exerts control over the decision between self-renewal and differentiation at the transcriptional, post-transcriptional and epigenetic levels. Recent evidence of alternative pluripotency states indicates the regulatory flexibility of this network...
January 3, 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28029164/development-modifying-sex-in-flies
#3
Denise Waldron
No abstract text is available yet for this article.
December 28, 2016: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28029163/rna-the-code-in-the-cap
#4
Linda Koch
No abstract text is available yet for this article.
December 28, 2016: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28029162/genetic-engineering-a-genome-editing-off-switch
#5
Ross Cloney
No abstract text is available yet for this article.
December 28, 2016: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28029161/down-syndrome-and-the-complexity-of-genome-dosage-imbalance
#6
Stylianos E Antonarakis
Down syndrome (also known as trisomy 21) is the model human phenotype for all genomic gain dosage imbalances, including microduplications. The functional genomic exploration of the post-sequencing years of chromosome 21, and the generation of numerous cellular and mouse models, have provided an unprecedented opportunity to decipher the molecular consequences of genome dosage imbalance. Studies of Down syndrome could provide knowledge far beyond the well-known characteristics of intellectual disability and dysmorphic features, as several other important features, including congenital heart defects, early ageing, Alzheimer disease and childhood leukaemia, are also part of the Down syndrome phenotypic spectrum...
December 28, 2016: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/27990020/genetic-engineering-create-ing-genome-wide-designed-mutations
#7
Darren J Burgess
No abstract text is available yet for this article.
December 19, 2016: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/27990019/transcriptional-architecture-of-the-mammalian-circadian-clock
#8
Joseph S Takahashi
Circadian clocks are endogenous oscillators that control 24-hour physiological and behavioural processes in organisms. These cell-autonomous clocks are composed of a transcription-translation-based autoregulatory feedback loop. With the development of next-generation sequencing approaches, biochemical and genomic insights into circadian function have recently come into focus. Genome-wide analyses of the clock transcriptional feedback loop have revealed a global circadian regulation of processes such as transcription factor occupancy, RNA polymerase II recruitment and initiation, nascent transcription, and chromatin remodelling...
December 19, 2016: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/27941868/mosaicism-in-health-and-disease-clones-picking-up-speed
#9
Lars A Forsberg, David Gisselsson, Jan P Dumanski
Post-zygotic variation refers to genetic changes that arise in the soma of an individual and that are not usually inherited by the next generation. Although there is a paucity of research on such variation, emerging studies show that it is common: individuals are complex mosaics of genetically distinct cells, to such an extent that no two somatic cells are likely to have the exact same genome. Although most types of mutation can be involved in post-zygotic variation, structural genetic variants are likely to leave the largest genomic footprint...
December 12, 2016: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/27867195/order-from-clutter-selective-interactions-at-mammalian-replication-origins
#10
Mirit I Aladjem, Christophe E Redon
Mammalian chromosome duplication progresses in a precise order and is subject to constraints that are often relaxed in developmental disorders and malignancies. Molecular information about the regulation of DNA replication at the chromatin level is lacking because protein complexes that initiate replication seem to bind chromatin indiscriminately. High-throughput sequencing and mathematical modelling have yielded detailed genome-wide replication initiation maps. Combining these maps and models with functional genetic analyses suggests that distinct DNA-protein interactions at subgroups of replication initiation sites (replication origins) modulate the ubiquitous replication machinery and supports an emerging model that delineates how indiscriminate DNA-binding patterns translate into a consistent, organized replication programme...
November 21, 2016: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/27867194/regulatory-activities-of-transposable-elements-from-conflicts-to-benefits
#11
Edward B Chuong, Nels C Elde, C├ędric Feschotte
Transposable elements (TEs) are a prolific source of tightly regulated, biochemically active non-coding elements, such as transcription factor-binding sites and non-coding RNAs. Many recent studies reinvigorate the idea that these elements are pervasively co-opted for the regulation of host genes. We argue that the inherent genetic properties of TEs and the conflicting relationships with their hosts facilitate their recruitment for regulatory functions in diverse genomes. We review recent findings supporting the long-standing hypothesis that the waves of TE invasions endured by organisms for eons have catalysed the evolution of gene-regulatory networks...
November 21, 2016: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/27840429/making-sense-of-genomic-islands-of-differentiation-in-light-of-speciation
#12
Jochen B W Wolf, Hans Ellegren
As populations diverge, genetic differences accumulate across the genome. Spurred by rapid developments in sequencing technology, genome-wide population surveys of natural populations promise insights into the evolutionary processes and the genetic basis underlying speciation. Although genomic regions of elevated differentiation are the focus of searches for 'speciation genes', there is an increasing realization that such genomic signatures can also arise by alternative processes that are not related to population divergence, such as linked selection...
November 14, 2016: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/27840428/dissecting-the-genetics-of-complex-traits-using-summary-association-statistics
#13
Bogdan Pasaniuc, Alkes L Price
During the past decade, genome-wide association studies (GWAS) have been used to successfully identify tens of thousands of genetic variants associated with complex traits and diseases. These studies have produced extensive repositories of genetic variation and trait measurements across large numbers of individuals, providing tremendous opportunities for further analyses. However, privacy concerns and other logistical considerations often limit access to individual-level genetic data, motivating the development of methods that analyse summary association statistics...
November 14, 2016: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/27795565/non-coding-rna-deciphering-the-rules-of-microrna-targeting
#14
Ross Cloney
No abstract text is available yet for this article.
October 31, 2016: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/27795564/a-network-biology-perspective-of-microrna-function-and-dysfunction-in-cancer
#15
Cameron P Bracken, Hamish S Scott, Gregory J Goodall
MicroRNAs (miRNAs) participate in most aspects of cellular differentiation and homeostasis, and consequently have roles in many pathologies, including cancer. These small non-coding RNAs exert their effects in the context of complex regulatory networks, often made all the more extensive by the inclusion of transcription factors as their direct targets. In recent years, the increased availability of gene expression data and the development of methodologies that profile miRNA targets en masse have fuelled our understanding of miRNA functions, and of the sources and consequences of miRNA dysregulation...
October 31, 2016: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/27773923/technique-see-and-seq-the-regulome
#16
Linda Koch
No abstract text is available yet for this article.
October 24, 2016: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/27773922/the-state-of-play-in-higher-eukaryote-gene-annotation
#17
Jonathan M Mudge, Jennifer Harrow
A genome sequence is worthless if it cannot be deciphered; therefore, efforts to describe - or 'annotate' - genes began as soon as DNA sequences became available. Whereas early work focused on individual protein-coding genes, the modern genomic ocean is a complex maelstrom of alternative splicing, non-coding transcription and pseudogenes. Scientists - from clinicians to evolutionary biologists - need to navigate these waters, and this has led to the design of high-throughput, computationally driven annotation projects...
October 24, 2016: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/27916984/gene-therapy-in-vivo-gene-editing-in-non-dividing-cells
#18
Denise Waldron
No abstract text is available yet for this article.
January 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/27890926/cancer-genomics-single-cell-rna-seq-to-decipher-tumour-architecture
#19
Ross Cloney
No abstract text is available yet for this article.
January 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/27890925/dna-elements-the-ins-and-outs-of-enhancer-validation
#20
Linda Koch
No abstract text is available yet for this article.
January 2017: Nature Reviews. Genetics
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