journal
MENU ▼
Read by QxMD icon Read
search

Nature Reviews. Genetics

journal
https://www.readbyqxmd.com/read/27890926/cancer-genomics-single-cell-rna-seq-to-decipher-tumour-architecture
#1
Ross Cloney
No abstract text is available yet for this article.
November 28, 2016: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/27890925/dna-elements-the-ins-and-outs-of-enhancer-validation
#2
Linda Koch
No abstract text is available yet for this article.
November 28, 2016: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/27867195/order-from-clutter-selective-interactions-at-mammalian-replication-origins
#3
Mirit I Aladjem, Christophe E Redon
Mammalian chromosome duplication progresses in a precise order and is subject to constraints that are often relaxed in developmental disorders and malignancies. Molecular information about the regulation of DNA replication at the chromatin level is lacking because protein complexes that initiate replication seem to bind chromatin indiscriminately. High-throughput sequencing and mathematical modelling have yielded detailed genome-wide replication initiation maps. Combining these maps and models with functional genetic analyses suggests that distinct DNA-protein interactions at subgroups of replication initiation sites (replication origins) modulate the ubiquitous replication machinery and supports an emerging model that delineates how indiscriminate DNA-binding patterns translate into a consistent, organized replication programme...
November 21, 2016: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/27867194/regulatory-activities-of-transposable-elements-from-conflicts-to-benefits
#4
Edward B Chuong, Nels C Elde, Cédric Feschotte
Transposable elements (TEs) are a prolific source of tightly regulated, biochemically active non-coding elements, such as transcription factor-binding sites and non-coding RNAs. Many recent studies reinvigorate the idea that these elements are pervasively co-opted for the regulation of host genes. We argue that the inherent genetic properties of TEs and the conflicting relationships with their hosts facilitate their recruitment for regulatory functions in diverse genomes. We review recent findings supporting the long-standing hypothesis that the waves of TE invasions endured by organisms for eons have catalysed the evolution of gene-regulatory networks...
November 21, 2016: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/27867193/from-profiles-to-function-in-epigenomics
#5
Stefan H Stricker, Anna Köferle, Stephan Beck
Myriads of epigenomic features have been comprehensively profiled in health and disease across cell types, tissues and individuals. Although current epigenomic approaches can infer function for chromatin marks through correlation, it remains challenging to establish which marks actually have causative roles in gene regulation and other processes. After revisiting how classical approaches have addressed this question in the past, we discuss the current state of epigenomic profiling and how functional information can be indirectly inferred...
November 21, 2016: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/27867192/dna-repair-rna-dna-hybrids-double-edged-swords
#6
Denise Waldron
No abstract text is available yet for this article.
November 21, 2016: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/27840430/microbial-genome-wide-association-studies-lessons-from-human-gwas
#7
Robert A Power, Julian Parkhill, Tulio de Oliveira
The reduced costs of sequencing have led to whole-genome sequences for a large number of microorganisms, enabling the application of microbial genome-wide association studies (GWAS). Given the successes of human GWAS in understanding disease aetiology and identifying potential drug targets, microbial GWAS are likely to further advance our understanding of infectious diseases. These advances include insights into pressing global health problems, such as antibiotic resistance and disease transmission. In this Review, we outline the methodologies of GWAS, the current state of the field of microbial GWAS, and how lessons from human GWAS can direct the future of the field...
November 14, 2016: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/27840429/making-sense-of-genomic-islands-of-differentiation-in-light-of-speciation
#8
Jochen B W Wolf, Hans Ellegren
As populations diverge, genetic differences accumulate across the genome. Spurred by rapid developments in sequencing technology, genome-wide population surveys of natural populations promise insights into the evolutionary processes and the genetic basis underlying speciation. Although genomic regions of elevated differentiation are the focus of searches for 'speciation genes', there is an increasing realization that such genomic signatures can also arise by alternative processes that are not related to population divergence, such as linked selection...
November 14, 2016: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/27840428/dissecting-the-genetics-of-complex-traits-using-summary-association-statistics
#9
Bogdan Pasaniuc, Alkes L Price
During the past decade, genome-wide association studies (GWAS) have been used to successfully identify tens of thousands of genetic variants associated with complex traits and diseases. These studies have produced extensive repositories of genetic variation and trait measurements across large numbers of individuals, providing tremendous opportunities for further analyses. However, privacy concerns and other logistical considerations often limit access to individual-level genetic data, motivating the development of methods that analyse summary association statistics...
November 14, 2016: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/27818507/the-origin-and-evolution-of-cell-types
#10
Detlev Arendt, Jacob M Musser, Clare V H Baker, Aviv Bergman, Connie Cepko, Douglas H Erwin, Mihaela Pavlicev, Gerhard Schlosser, Stefanie Widder, Manfred D Laubichler, Günter P Wagner
Cell types are the basic building blocks of multicellular organisms and are extensively diversified in animals. Despite recent advances in characterizing cell types, classification schemes remain ambiguous. We propose an evolutionary definition of a cell type that allows cell types to be delineated and compared within and between species. Key to cell type identity are evolutionary changes in the 'core regulatory complex' (CoRC) of transcription factors, that make emergent sister cell types distinct, enable their independent evolution and regulate cell type-specific traits termed apomeres...
November 7, 2016: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/27795565/non-coding-rna-deciphering-the-rules-of-microrna-targeting
#11
Ross Cloney
No abstract text is available yet for this article.
October 31, 2016: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/27795564/a-network-biology-perspective-of-microrna-function-and-dysfunction-in-cancer
#12
Cameron P Bracken, Hamish S Scott, Gregory J Goodall
MicroRNAs (miRNAs) participate in most aspects of cellular differentiation and homeostasis, and consequently have roles in many pathologies, including cancer. These small non-coding RNAs exert their effects in the context of complex regulatory networks, often made all the more extensive by the inclusion of transcription factors as their direct targets. In recent years, the increased availability of gene expression data and the development of methodologies that profile miRNA targets en masse have fuelled our understanding of miRNA functions, and of the sources and consequences of miRNA dysregulation...
October 31, 2016: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/27795563/genomics-mapping-meiotic-breaks
#13
Ross Cloney
No abstract text is available yet for this article.
October 31, 2016: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/27795562/loss-of-function-genetic-tools-for-animal-models-cross-species-and-cross-platform-differences
#14
Benjamin E Housden, Matthias Muhar, Matthew Gemberling, Charles A Gersbach, Didier Y R Stainier, Geraldine Seydoux, Stephanie E Mohr, Johannes Zuber, Norbert Perrimon
Our understanding of the genetic mechanisms that underlie biological processes has relied extensively on loss-of-function (LOF) analyses. LOF methods target DNA, RNA or protein to reduce or to ablate gene function. By analysing the phenotypes that are caused by these perturbations the wild-type function of genes can be elucidated. Although all LOF methods reduce gene activity, the choice of approach (for example, mutagenesis, CRISPR-based gene editing, RNA interference, morpholinos or pharmacological inhibition) can have a major effect on phenotypic outcomes...
October 31, 2016: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/27773923/technique-see-and-seq-the-regulome
#15
Linda Koch
No abstract text is available yet for this article.
October 24, 2016: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/27773922/the-state-of-play-in-higher-eukaryote-gene-annotation
#16
Jonathan M Mudge, Jennifer Harrow
A genome sequence is worthless if it cannot be deciphered; therefore, efforts to describe - or 'annotate' - genes began as soon as DNA sequences became available. Whereas early work focused on individual protein-coding genes, the modern genomic ocean is a complex maelstrom of alternative splicing, non-coding transcription and pseudogenes. Scientists - from clinicians to evolutionary biologists - need to navigate these waters, and this has led to the design of high-throughput, computationally driven annotation projects...
October 24, 2016: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/27773921/genetic-variation-diving-deep-into-the-genome
#17
Denise Waldron
No abstract text is available yet for this article.
October 24, 2016: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/27748376/chromatin-going-a-tad-out-on-a-limb
#18
Linda Koch
No abstract text is available yet for this article.
October 17, 2016: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/27748375/paramutation-and-related-phenomena-in-diverse-species
#19
Jay B Hollick
Paramutation describes a process that results in heritable epigenetic changes of gene regulation and trans-homologue interactions. Recent discoveries in model organisms have highlighted roles for the respective nuclear systems that regulate transposons via small RNA molecules both for paramutation and for defining transgenerational inheritance. Differences between plants and animals may influence specific transmission behaviours but the involvement of small RNA-based mechanisms identifies a unifying eukaryotic theme...
October 17, 2016: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/27694809/epigenetic-inheritance-of-acquired-traits-through-sperm-rnas-and-sperm-rna-modifications
#20
Qi Chen, Wei Yan, Enkui Duan
Once deemed heretical, emerging evidence now supports the notion that the inheritance of acquired characteristics can occur through ancestral exposures or experiences and that certain paternally acquired traits can be 'memorized' in the sperm as epigenetic information. The search for epigenetic factors in mammalian sperm that transmit acquired phenotypes has recently focused on RNAs and, more recently, RNA modifications. Here, we review insights that have been gained from studying sperm RNAs and RNA modifications, and their roles in influencing offspring phenotypes...
October 3, 2016: Nature Reviews. Genetics
journal
journal
35149
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"