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Journal of Toxicology and Environmental Health. Part A

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https://www.readbyqxmd.com/read/29764335/comparative-bioaccumulation-and-effects-of-purified-and-cellular-extract-of-cylindrospermopsin-to-freshwater-fish-hoplias-malabaricus
#1
Rodrigo de Cássio da Silva, Sonia Regina Grötzner, Daniele Dietrich Moura Costa, Juan Ramón Esquivel Garcia, Juan Muelbert, Valéria Freitas de Magalhães, Francisco Filipak Neto, Ciro Alberto de Oliveira Ribeiro
Many tropical freshwater ecosystems are impacted by cyanobacteria blooms increasing the risk of cyanotoxins exposure to aquatic organisms while human populations may be exposed by eating fish, drinking water, or dermal swimming. However, few toxicological data are available on the influence of cyanobacteria blooms in particular, cylindrospermopsin (CYN) on Brazilian neotropical fish. A number of studies demonstrated the ability of CYN to bioaccumulate in freshwater organisms and consequently enter the human food chain...
May 15, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29737961/toxicity-assessment-of-cobalt-ferrite-nanoparticles-on-wheat-plants
#2
J López-Luna, M M Camacho-Martínez, F A Solís-Domínguez, M C González-Chávez, R Carrillo-González, S Martinez-Vargas, O F Mijangos-Ricardez, M C Cuevas-Díaz
Cobalt ferrite nanoparticles (NPs) have received increasing attention due to their widespread therapeutic and agricultural applicability. In the environmental field, dry powder- and ferrofluid-suspended cobalt ferrite NPs were found to be useful for removing heavy metals and metalloids from water, while diluted suspensions of cobalt ferrite NP have been promisingly applied in medicine. However, the potential toxicological implications of widespread exposure are still unknown. Since cobalt ferrite NPs are considered residual wastes of environmental or medical applications, plants may serve as a point-of-entry for engineered nanomaterials as a result of consumption of these plants...
May 8, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29714641/in-vitro-characterization-of-cutaneous-immunotoxicity-of-immortalized-human-keratinocytes-hacat-exposed-to-reactive-and-disperse-textile-dyes
#3
Daniela Morais Leme, Andrea Sehr, Tamara Grummt, Jenifer Pendiuk Gonçalves, Thiago Jacomasso, Sheila Maria Brochado Winnischofer, Francine Bittencourt Potrich, Carolina Camargo de Oliveira, Edvaldo da Silva Trindade, Danielle Palma de Oliveira
Several synthetic dyes are used by textile industry for supplying the market of colored clothes. However, these chemicals have been associated with a variety of adverse human health effects, including textile dermatitis. Thus, there is a growing concern to identify textile dyes potentially as skin immunotoxicants. The aim of this in vitro study was to characterize the immunotoxic potential of reactive (Reactive Green 19 [RG19], Reactive Blue 2 [RB2], Reactive Black 5 [RB5]) and disperse (Disperse Red 1 [DR1]) textile dyes using a dermal cell line...
May 1, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29694274/risk-assessment-of-n-nitrosodiethylamine-ndea-and-n-nitrosodiethanolamine-ndela-in-cosmetics
#4
Duck Soo Lim, Tae Hyun Roh, Min Kook Kim, Yong Chan Kwon, Seul Min Choi, Seung Jun Kwack, Kyu Bong Kim, Sungpil Yoon, Hyung Sik Kim, Byung-Mu Lee
N-nitrosamines and their precursors found in cosmetics may be carcinogenic in humans. Thus the aim of this study was to carry out risk assessment for N-nitrosamines (N-nitrosodiethanolamine [NDELA], N-nitrosodiethylamine [NDEA]) and amines (triethanolamine [TEA], diethanolamine [DEA]) levels in cosmetics determined using validated liquid chromatography-tandem mass spectrometry (LC-MS/MS) procedures. NDELA and NDEA concentrations were present at levels of "not detected" (N.D.) to 596.5 μg/kg and N...
April 25, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29693510/airway-and-systemic-inflammatory-responses-to-ultrafine-carbon-black-particles-and-ozone-in-older-healthy-subjects
#5
Olaf Holz, Karsten Heusser, Meike Müller, Horst Windt, Katharina Schwarz, Christoph Schindler, Jens Tank, Jens M Hohlfeld, Jens Jordan
Increased adverse health effects in older subjects due to exposure to ambient air pollutants may be related to the inflammatory response induced by these contaminants. The aim of this study was to assess airway and systemic inflammatory responses in older healthy subjects to a controlled experimental exposure with spark-generated elemental carbon black ultrafine particles (cbUFPs) and ozone (O3 ). Twenty healthy subjects, age 52-75 years, were exposed on three occasions separated by at least 8 weeks. The exposures to filtered air (FA), to cbUFP (50 μg/m3 ), or to cbUFP in combination with 250 ppb ozone (cbUFP + O3 ) for 3 h with intermittent exercise were performed double blind, and in random order...
April 25, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29693504/cylindrospermopsin-toxicity-in-mice-following-a-90-d-oral-exposure
#6
N Chernoff, D J Hill, I Chorus, D L Diggs, H Huang, D King, J R Lang, T-T Le, J E Schmid, G S Travlos, E M Whitley, R E Wilson, C R Wood
Cylindrospermopsin (CYN) is a toxin associated with numerous species of freshwater cyanobacteria throughout the world. It is postulated to have caused an episode of serious illnesses in Australia through treated drinking water, as well as lethal effects in livestock exposed to water from farm ponds. Toxicity included effects indicative of both hepatic and renal dysfunction. In humans, symptoms progressed from initial hepatomegaly, vomiting, and malaise to acidosis and hypokalemia, bloody diarrhea, and hyperemia in mucous membranes...
April 25, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29667508/fine-particulate-air-pollution-associated-with-increased-risk-of-hospital-admissions-for-hypertension-in-a-tropical-city-kaohsiung-taiwan
#7
Shang-Shyue Tsai, Chia-Ying Tsai, Chun-Yuh Yang
The aim of this study was to assess whether a correlation exists between fine particles (PM2.5 ) levels and number of hospital admissions for hypertension in Kaohsiung, Taiwan. Hospital admission frequency and ambient air pollution data were obtained for Kaohsiung for 2009-2013. A time-stratified case-crossover method was used to estimate relative risk for hospital admissions, controlling for weather, day of the week, seasonality, and long-term time trends. Odds ratios and 95% confidence intervals were calculated for a 10 µg/m3 increment of PM2...
April 18, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29652224/in-vitro-functional-analysis-of-human-cytochrome-p450-2a13-genetic-variants-p450-2a13-2-3-4-and-10
#8
Vitchan Kim, Sora Yeom, Yejin Lee, Hyoung-Goo Park, Myung-A Cho, Harim Kim, Donghak Kim
Humans possess three cytochrome P450 enzymes in the 2A subfamily (2A6, 2A7, and 2A13). P450 2A13 is mainly expressed in the human trachea and lung, whereas P450 2A6 is found in human liver. The P450 2A13 enzyme may be considered as the primary enzyme responsible for metabolic activation of many tobacco-specific carcinogens. Genetic variations significantly influence the toxicological consequences attributed to tobacco smoking. The aim of this study was to examine the in vitro functional activities of five P450 2A13 genetic variations (R257C, 133_134insT, R101Q, I331T, and R257C/I331T) in P450 2A13*2, *3, *4, and *10 alleles...
April 13, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29641933/arsenic-association-with-circulating-oxidized-low-density-lipoprotein-in-a-native-american-community
#9
Molly E Harmon, Johnnye Lewis, Curtis Miller, Joseph Hoover, Abdul-Mehdi S Ali, Chris Shuey, Miranda Cajero, Selita Lucas, Bernadette Pacheco, Esther Erdei, Sandy Ramone, Teddy Nez, Matthew J Campen, Melissa Gonzales
More than 500 abandoned uranium (U) mines within the Navajo Nation contribute U, arsenic (As) and other metals to groundwater, soil and potentially air through airborne transport. The adverse cardiovascular health effects attributed to cumulative exposure to these metals remains uncertain. The aim of this study was to examine whether environmental exposure to these metals may promote or exacerbate the oxidation of low-density lipoprotein (LDL) cholesterol in this Native American population. The correlation of cardiovascular biomarkers (oxidized LDL (oxLDL) and C-reactive protein (CRP)) from a Navajo cohort (n = 252) with mean annual As and U intakes from water and urine metals was estimated using linear regression...
April 11, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29641932/identification-and-characterization-of-amiodarone-metabolites-in-rats-using-uplc-esi-qtofms-based-untargeted-metabolomics-approach
#10
Eun Sook Jeong, Gabin Kim, Daeun Yim, Kyung-Sik Moon, Su-Jun Lee, Jae-Gook Shin, Dong Hyun Kim
Amiodarone is a class III anti-arrhythmic benzofuran derivative extensively utilized in treatment of life-threatening ventricular and supraventricular arrhythmias. However, amiodarone also produces adverse side effects including liver injury due to its metabolites rather than parent drug. The purpose of the present study was to identify metabolites of amiodarone in the plasma and urine of rats administered the drug by using an untargeted metabolomics approach. Drug metabolites were profiled by ultra-performance liquid chromatography-linked electrospray ionization quadrupole time-of-flight mass spectrometry (UPLC-ESI-QTOFMS) and results subjected to multivariate data analysis...
April 11, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29630468/protective-effect-of-paeoniae-radix-alba-root-extract-on-immune-alterations-in-mice-with-atopic-dermatitis
#11
Gwang-Ho Jo, So-Nam Kim, Mun-Ja Kim, Yong Heo
Atopic dermatitis is a progressive inflammatory disease characterized by type 2 helper T cell (TH 2) reactivity. The aim of this study was to examine the therapeutic effects of Paeoniae radix alba root extract using a murine model of atopic dermatitis. Atopic dermatitis was induced in a murine model characterized by immune alterations skewed toward TH 2 reactivity and pathophysiological dermal alterations which resemble human atopic dermatitis. The root extract at 1% or 6% was applied to the mouse dorsal skin for 3 weeks following induction of atopic dermatitis...
April 9, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29617195/natural-tissue-concentrations-in-adult-ambystoma-maculatum-and-larval-dna-damage-from-exposure-to-arsenic-and-chromium
#12
Steven Gardner, George Cline, Nixon Mwebi, James Rayburn
Arsenic (As) and chromium (Cr) are two contaminants that are detected in aquatic and terrestrial habitats. Using the spotted salamander, Ambystoma maculatum, to assess impacts from these contaminants may be advantageous as adults live and breed in such environments. Adult amphibians typically exhibit elevated tissue concentrations of contaminants present in their environment, while larval stages were found to exhibit increased sensitivity to pollutants. From January through March of 2015, during the spring breeding season, 5 adults and approximately 32 egg masses were collected from a local breeding site...
April 4, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29608440/serum-and-urine-toxicometabolomics-following-gentamicin-induced-nephrotoxicity-in-male-sprague-dawley-rats
#13
Sung Ha Ryu, Ji Won Kim, Dahye Yoon, Suhkmann Kim, Kyu-Bong Kim
Gentamicin (GM) is an aminoglycoside antibiotic used in treatment of various types of bacterial infections, but the major adverse effect is drug-induced nephrotoxicity. This study aimed to determine biomarkers that might predict nephrotoxicity initiated by GM using serum or urinary proton nuclear magnetic resonance (1 H NMR) spectral data in male Sprague-Dawley rats. GM (0, 30, or 300 mg/kg/d) was intraperitoneally administered for 3 consecutive days. Animals were sacrificed 2 d (D2) or 8 d (D8) after last administration of GM in order to perform analysis of serum biochemistries and histopathologic examination...
April 2, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29590002/low-dose-cadmium-exposure-exacerbates-polyhexamethylene-guanidine-induced-lung-fibrosis-in-mice
#14
Min-Seok Kim, Sung-Hwan Kim, Doin Jeon, Hyeon-Young Kim, Jin-Young Han, Bumseok Kim, Kyuhong Lee
Cadmium (Cd) is a toxic metal present in tobacco smoke, air, food, and water. Inhalation is an important route of Cd exposure, and lungs are one of the main target organs for metal-induced toxicity. Cd inhalation is associated with an increased risk of pulmonary diseases. The present study aimed to assess the effects of repeated exposure to low-dose Cd in a mouse model of polyhexamethylene guanidine (PHMG)-induced lung fibrosis. Mice were grouped into the following groups: vehicle control (VC), PHMG, cadmium chloride (CdCl2 ), and PHMG + CdCl2 ...
March 28, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29589992/non-cancer-cancer-and-dermal-sensitization-risk-assessment-of-heavy-metals-in-cosmetics
#15
Duck Soo Lim, Tae Hyun Roh, Min Kook Kim, Yong Chan Kwon, Seul Min Choi, Seung Jun Kwack, Kyu Bong Kim, Sungpil Yoon, Hyung Sik Kim, Byung-Mu Lee
The heavy metal content of cosmetics may be a cause for concern in that exposure to these metals is associated with adverse consequences. Thus, the aim of this study was to assess consequences attributed to exposure to heavy metals in cosmetics as determined by non-cancer, cancer, and sensitization risks methodologies. The quantification and exposure assessments of aluminum (Al), chromium (Cr), manganese (Mn), iron (Fe), cobalt (Co), nickel (Ni), copper (Cu), zinc (Zn), arsenic (As), lead (Pb), mercury (Hg), cadmium (Cd), antimony (Sb), and titanium (Ti) were performed by inductively coupled plasma-mass spectrometry...
March 28, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29557728/evaluation-of-subchronic-exposure-to-triclosan-on-hepatorenal-and-reproductive-toxicities-in-prepubertal-male-rats
#16
Lee Ena, Jong Seung Lim, Ji Yeon Son, Yu Jin Park, Yong Hee Lee, Ji Yeong Kim, Seung Jun Kwack, Byung Mu Lee, Mee-Young Ahn, Hyung Sik Kim
Triclosan (TCS), a common antimicrobial ingredient, is present in many consumer products, including soaps, shampoos, and toothpaste. Owing to its widespread use, potential adverse effects on animals and humans may arise from lifetime exposure, but data on chronic prepubertal exposure of TCS are still lacking. The aim of the present study was to investigate the influence of subchronic TCS exposure (0.25, 25, 250, or 750 mg/kg) on target organ toxicity in prepubertal male rats. After daily administration of TCS to rats by oral gavage for 60 d, a significant reduction in body weight and relative weights of liver, kidneys, testes, and adrenal glands was observed in the 750-mg/kg (high dose) group...
March 20, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29557727/absorption-metabolism-and-excretion-of-14-c-evogliptin-tartrate-in-male-rats-and-dogs
#17
Dae Young Lee, Ju-Hyun Kim, Hyun Joo Shim, Hyeon-Uk Jeong, Hye Suk Lee
The objective of this study was to determine the absorption, excretion, and metabolism of a novel, oral antihyperglycemic drug, evogliptin, in male rats and dogs. Plasma, urine, feces, and expired air samples were collected after a single oral dose administration of [14 C]evogliptin, samples were analyzed by measuring overall radioactivity levels using high-performance liquid chromatography (HPLC), and radioactivity levels were measured by utilizing LC-tandem mass spectrometry (LC-MS/MS). The total amounts of radioactivity excreted in urine, feces, and expired air up to 168 h after administration of [14 C]evogliptin tartrate to rats (30 mg evogliptin/kg) and dogs (10 mg evogliptin/kg) were 96...
March 20, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29557720/hepatic-damage-exacerbates-cisplatin-induced-acute-kidney-injury-in-sprague-dawley-rats
#18
Ji Su Kim, Ji Yeon Son, Kyeong Seok Kim, Hyun Jung Lim, Mee-Young Ahn, Seung Jun Kwack, Young-Mi Kim, Kwang Youl Lee, Jaewon Lee, Byung Mu Lee, Hyung Sik Kim
The objective of this study was to elucidate the effect of hepatic damage on cisplatin (CDDP)-induced acute kidney injury (AKI). Thioacetamide (TAA, 150 mg/kg), a hepatotoxicant, was intraperitoneally (i.p.) injected to male Sprague-Dawley rats for 3 d prior to CDDP (5 mg/kg, i.p.) injection. All animals were sacrificed 5 d after CDDP treatment, and urine or blood was obtained to measure various parameters. No significant changes in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity were observed after CDDP treatment...
March 20, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29672251/advances-in-toxicological-research-and-risk-assessment
#19
Byung-Mu Lee, Hyung Sik Kim, Young Jin Chun
No abstract text is available yet for this article.
2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29537937/effects-of-suspended-drill-cuttings-on-the-coral-lophelia-pertusa-using-pulsed-and-continuous-exposure-scenarios
#20
Thierry Baussant, Marianne Nilsen, Elisa Ravagnan, Stig Westerlund, Sreerekha Ramanand
This study aimed at providing confidence in the predictability of the impacts of drill cuttings (DC) discharge on the cold-water coral Lophelia pertusa. L. pertusa was exposed to DC from offshore exploration in the lab with the goal to assess precautionary thresholds of effects. Two exposure scenarios with DC were tested: a long-term (LT) pulsed exposure (12 weeks, peak concentrations: 2-50 mg/L, mean concentrations: 1-25 mg/L) and a short-term (ST) continuous exposure (2.5 weeks, mean concentrations: 4-42 mg/L)...
2018: Journal of Toxicology and Environmental Health. Part A
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