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Journal of Toxicology and Environmental Health. Part A

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https://www.readbyqxmd.com/read/29144200/mechanisms-underlying-melatonin-mediated-prevention-of-fenvalerate-induced-behavioral-and-oxidative-toxicity-in-zebrafish
#1
Jingjing Han, Cheng Ji, Yichen Guo, Rui Yan, Ting Hong, Yuanyan Dou, Yan An, Shasha Tao, Fenju Qin, Jihua Nie, Chen Ji, Han Wang, Jian Tong, Wei Xiao, Jie Zhang
The neurotoxic effects attributed to the pesticide fenvalerate (FEN) are well-established. The aim of this study was to determine whether melatonin (MLT) was able to protect against FEN-induced behavior, oxidative stress, apoptosis, and neurogenesis using zebrafish (Danio rerio) model. Zebrafish exposed to 100 μg/L FEN for 120 h exhibited decreased swimming activity accompanied by downregulated expression of neurogenesis-related genes (Dlx2, Shha, Ngn1, Elavl3, and Gfap), suggesting that neurogenesis were impaired...
November 16, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29131715/microplastic-potentiates-triclosan-toxicity-to-the-marine-copepod-acartia-tonsa-dana
#2
Kristian Syberg, Anne Nielsen, Farhan R Khan, Gary T Banta, Annemette Palmqvist, Per M Jepsen
Microplastics (MP) are contaminants of environmental concern partly due to plastics ability to sorb and transport hydrophobic organic contaminants (HOC). The importance of this "vector effect" is currently being debated in the scientific community. This debate largely ignores that the co-exposures of MP and HOC are mixtures of hazardous agents, which can be addressed from a mixture toxicity perspective. In this study, mixture effects of polyethylene microbeads (MP) and triclosan (TCS) (a commonly used antibacterial agent in cosmetics) were assessed on the marine copepod Acartia tonsa...
November 13, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29049001/effects-of-melatonin-on-mechanisms-involved-in-hypertension-using-human-umbilical-vein-endothelial-cells
#3
Guangfang Shao, Suping Zhang, Jihua Nie, Jianxiang Li, Jian Tong
Changes in diurnal rhythmicity in blood pressure (BP) are associated with hypertension and consequent cardiovascular damage. The involvement of diurnal rhythmicity as a pathogenic factor in hypertension is not fully understood. Since the hormone melatonin (MLT) regulates circadian rhythm, it was also of interest to determine whether this hormone played a role in hypertension-related alterations in circadian rhythm. Thus the aim of this study was to examine the mechanisms underlying MLT-mediated antihypertension...
October 19, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29048996/aberrant-dna-methylation-in-radon-and-or-cigarette-smoke-induced-malignant-transformation-in-beas-2b-human-lung-cell-line
#4
Huanhuan Huang, Yahui Ji, Jiayu Zhang, Zhigang Su, Mingxing Liu, Jian Tong, Cuicui Ge, Tao Chen, Jianxiang Li
It is well known that cigarette smoking (CS) and/or radon (Rn) induce malignant transformation in lung cells. To investigate the mechanisms underlying lung carcinogenesis induced by CS, Rn; or Rn followed by CS using BEAS-2B cell line derived from human bronchial epithelial cells. BEAS-2B cells were exposed to either Rn (20,000 Bq/m(3)) for 30 min or CS (20%) for 10 min or Rn followed by CS for 40 min. Global and gene-specific DNA methylation modifications were measured by microarray and methylation-specific polymerase chain reaction...
October 19, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29040059/circadian-rhythm-genes-mediate-fenvalerate-induced-inhibition-of-testosterone-synthesis-in-mouse-leydig-cells
#5
Yichen Guo, Ouxi Shen, Jingjing Han, Hongyu Duan, Siyuan Yang, Zhenghong Zhu, Jian Tong, Jie Zhang
Fenvalerate (Fen), a widely used pesticide, is known to impair male reproductive functions by mechanisms that remain to be elucidated. Recent studies indicated that circadian clock genes may play an important role in successful male reproduction. The aim of this study was to determine the effects of Fen on circadian clock genes involved in the biosynthesis of testosterone using TM3 cells derived from mouse Leydig cells. Data demonstrated that the circadian rhythm of testosterone synthesis in TM3 cells was disturbed following Fen treatment as evidenced by changes in the circadian rhythmicity of core clock genes (Bmal1, Rev-erbα, Rorα)...
October 17, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29020531/mechanisms-of-antibiotic-resistance-in-bacteria-mediated-by-silver-nanoparticles
#6
Chitrada Kaweeteerawat, Preeyawis Na Ubol, Sanirat Sangmuang, Sasitorn Aueviriyavit, Rawiwan Maniratanachote
Silver nanoparticles (AgNPs) are widely used in industry, consumer products, and medical appliances due to their efficient antimicrobial properties. However, information on environmental toxicity and bacterial impact of these particles is not completely elucidated. Results showed that AgNPs produced growth inhibition and oxidative stress in bacteria Escherichia coli (gram negative) and Staphylococcus aureus (gram positive), with half-maximal inhibitory concentrations (IC50) of 12 and 7 mg/L, respectively. Surprisingly, bacteria pre-exposed to sublethal dose of AgNPs exhibited increased resistance toward antibiotics (ampicillin and Pen-Strep) with IC50 elevated by 3-13-fold...
October 11, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29020526/antioxidant-and-mercury-chelating-activity-of-psidium-guajava-var-pomifera-l-leaves-hydroalcoholic-extract
#7
Antonio Ivanildo Pinho, Cláudia Sirlene Oliveira, Fabricio Luís Lovato, Emily Pansera Waczuk, Bruna Candia Piccoli, Aline Augusti Boligon, Nadghia Figueredo Leite, Henrique Douglas Melo Coutinho, Thais Posser, João Batista Teixeira Da Rocha, Jeferson Luis Franco
Mercury (Hg) is widely distributed in the environment and is known to produce several adverse effects in organisms. The aim of the present study was to examine the in vitro antioxidant activity and Hg chelating ability of the hydroalcoholic extract of Psidium guajava leaves (HEPG). In addition, the potential protective effects of HEPG against Hg(II) were evaluated using a yeast model (Saccharomyces cerevisiae). HEPG was found to exert significant antioxidant activity in 2,2-diphenyl-1-picrylhydrazyl scavenger and inhibition of lipid peroxidation induced by Fe(II) assays in a concentration-dependent manner...
October 11, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28956726/assessment-of-the-antioxidant-cytotoxic-and-genotoxic-potential-of-the-annona-muricata-leaves-and-their-influence-on-genomic-stability
#8
Nathália Oliveira Acésio, Guilherme Scarano Carrijo, Thales Henrique Batista, Jaqueline Lopes Damasceno, Mariana Beltrame Côrrea, Marcos Gomide Tozatti, Wilson Roberto Cunha, Denise Crispim Tavares
The popular use of Annona muricata L. is based upon a range of medicinal purposes, and the plant exhibits biological activities including antihyperglycemic, antiparasitic, and antitumor activities. The objectives of this study were to examine the antioxidant, cytotoxic, and genotoxic potential of the hydroalcoholic extract of A. muricata leaves (AMEs), as well as its effects on genotoxicity induced by methyl methanesulfonate (MMS) and hydrogen peroxide (H2O2). The results using 2,2-diphenyl-1-picrylhydrazyl assay showed that AME was able to scavenge 44...
September 28, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28956714/association-between-fine-particulate-air-pollution-and-hospital-admissions-for-chest-pain-in-a-subtropical-city-taipei-taiwan
#9
Chih-Cheng Chen, Chun-Yuh Yang
This study determined the association between fine particles (PM2.5) levels and hospital admissions for chest pain (CP) in Taipei, Taiwan. Hospital admissions for CP and ambient air pollution data for Taipei were obtained for the period 2009-2013. The relative risk of hospital admissions was estimated using a case-crossover approach, after controlling for weather variables, day of the week, seasonality, and long-term time trends. For single-pollutant models (without adjustment for other pollutants), increased frequency of CP admissions was significantly associated with PM2...
September 28, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28949828/effectiveness-of-amygdalus-mongolica-oil-in-hyperlipidemic-rats-and-underlying-antioxidant-processes
#10
Qian-Nan Zheng, Jia Wang, Hong-Bing Zhou, Shu-Fang Niu, Quan-Li Liu, Zhan-Jun Yang, He Wang, Yun-Shan Zhao, Song-Li Shi
The seeds of Amygdalus mongolica contain various constituents including flavonoids and vitamin E, which are known to exert antioxidant effects. However, the safety of the oil extract of this compound is not fully known. The aim of this study was to determine the physicochemical properties of A. mongolica oil, identify the constituents and subsequently assess the effectiveness of utilizing this seed extract in hyperlipidemia as an antioxidant agent. In particular, the toxicity and safety of A. mongolica oil were examined with emphasis on effects on blood lipids level and serum lipid peroxidation using a hyperlipidemia rat model...
September 26, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28910587/trichosanthin-attenuates-vascular-injury-induced-neointimal-hyperplasia-following-balloon-catheter-injury-in-rats
#11
Min Qiu, Zheng Yang, Xiao-Hua Guo, Yu-Ting Song, Ming An, Guo-Jun Zhao, Miao Song, Xiao-Min Zhao, Yun-Shan Zhao, Quan-Li Liu
Trichosanthin (TCS), isolated from the root tuber of Trichosantheskirilowii, a well-known traditional Chinese medicinal plant, belonging to the Cucurbitaceae family, was found to exhibit numerous biological and pharmacological activities including anti-inflammatory. However, the effects of TCS on arterial injury induced neointimal hyperplasia and inflammatory cell infiltration remains poorly understood. The aim of study was to examine the effectiveness of TCS on arterial injury-mediated inflammatory processes and underlying mechanisms...
September 14, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28895799/protective-effects-of-bellidifolin-in-hypoxia-induced-in-pheochromocytoma-cells-pc12-and-underlying-mechanisms
#12
Zhi-Ying Zhao, Yang-Yang Gao, Li Gao, Ming Zhang, He Wang, Chun-Hong Zhang
Bellidifolin, a xanthone compound derived from plants of Gentiana species, is known to exert a variety of pharmacological activities including anti-oxidation, anti-inflammatory and antitumor actions as well as a protective effect on cerebral ischemic nerve injury. The aim of this study was to examine the protective effects of bellidifolin on nerve injury produced by hypoxia and possible underlying mechanisms using pheochromocytoma cells (PC12). Data showed that the viability of PC12 cells subjected to hypoxia resulted in a significant decrease; however; pretreatment with certain concentrations of bellidifolin (20 or 40 μmol/L) prior to hypoxia significantly increased the survival rate...
September 12, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28891787/biochemical-approaches-to-assess-oxidative-stress-induced-by-exposure-to-natural-and-synthetic-dyes-in-early-life-stages-in-zebrafish
#13
Flavia R Abe, Carlos Gravato, Amadeu M V M Soares, Danielle P de Oliveira
Zebrafish early life stages were found to be sensitive to several synthetic dyes widely used in industries. However, as environmental concentrations of such contaminants are often at sublethal levels, more sensitive methods are required to determine early-warning adverse consequences. The aim of this study was to utilize a multibiomarker approach to examine underlying oxidative stress mechanisms triggered by sublethal concentrations of synthetic azo dye Basic Red 51 (BR51), the natural dye erythrostominone (ERY), and its light-degraded product using zebrafish embryos...
September 11, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28891756/evaluation-of-distribution-redox-parameters-and-genotoxicity-in-wistar-rats-co-exposed-to-silver-and-titanium-dioxide-nanoparticles
#14
Airton da Cunha Martins, Lara Ferreira Azevedo, Cecília Cristina de Souza Rocha, Maria Fernanda Hornos Carneiro, Vinicius Paula Venancio, Mara Ribeiro de Almeida, Lusânia Maria Greggi Antunes, Rodrigo de Carvalho Hott, Jairo Lisboa Rodrigues, Abayomi T Ogunjimi, Joseph A Adeyemi, Fernando Barbosa
The increasing production of silver nanoparticles (AgNPs) and titanium dioxide nanoparticles (TiO2NPs) has resulted in their elevated concentrations in the environment. This study was, therefore, aimed at determining the distribution, redox parameters, and genotoxic effects in male Wistar rats that were treated with either AgNP or TiO2NP individually, as well as under a co-exposure scenario. Animals were exposed via oral gavage to either sodium citrate buffer (vehicle), 0.5 mg/kg/day TiO2NP, 0.5 mg/kg/day AgNP or a mixture of TiO2NPs and AgNPs...
September 11, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28891753/the-influence-of-schisandrin-b-on-a-model-of-alzheimer-s-disease-using-%C3%AE-amyloid-protein-a%C3%AE-1-42-mediated-damage-in-sh-sy5y-neuronal-cell-line-and-underlying-mechanisms
#15
Ming Zhang, Hong-Xia Zheng, Yang-Yang Gao, Bo Zheng, Jing-Ping Liu, He Wang, Zhan-Jun Yang, Zhi-Ying Zhao
Schisandrin B, an active substance, is derived from Chinese herb fruit Wuweizi, which exerts various pharmacological activities and has displayed significant beneficial effects in ameliorating Alzheimer's disease (AD). The aim of this study was to further extend our examination for the use of schisandrin B extract in the potential treatment of AD effects by investigating DNA methylation (DNMT), known to be modified in this disease using SH-SY5Y neuronal cell line exposed to β-amyloid protein (Aβ1-42). In particular, the purpose of this investigation was to examine alterations in mRNA and protein expression of DNMT...
September 11, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28880816/5-aza-2-deoxycytidine-a-dna-methylation-inhibitor-induces-cytotoxicity-cell-cycle-dynamics-and-alters-expression-of-dna-methyltransferase-1-and-3a-in-mouse-hippocampus-derived-neuronal-ht22-cells
#16
Jing Yang, Xiaoli Tian, Jie Yang, Junhe Cui, Shuyuan Jiang, Rui Shi, You Liu, Xiaolei Liu, Wenqiang Xu, Wei Xie, Xiaoe Jia, Rengui Bade, Tao Zhang, Ming Zhang, Kerui Gong, Shaochun Yan, Zhanjun Yang, Guo Shao
Epigenetic processes such as DNA methylation are essential for processes of gene expression in normal mammalian development. DNA methyltransferases (DNMT) are responsible for initiating and maintaining DNA methylation. It is known that 5-Aza-CdR, an inhibitor of DNMT induces cytotoxicity by reducing DNMT activity in various tumor cell lines. However, disturbances in neuronal DNA methylation may also play a role in altered brain functions. Thus, it was of interest to determine whether alterations in DNA methylation might be associated with neuronal functions by using 5-Aza-CdR, on mouse hippocampus-derived neuronal HT22 cell line...
September 7, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28880814/investigation-of-full-scale-ozonation-at-a-municipal-wastewater-treatment-plant-using-a-toxicity-based-evaluation-concept
#17
Fabian Itzel, Linda Gehrmann, Helena Bielak, Paul Ebersbach, Andrea Boergers, Heinrich Herbst, Christian Maus, Anne Simon, Elke Dopp, Monika Hammers-Wirtz, Torsten C Schmidt, Jochen Tuerk
Effluents from municipal wastewater treatment plants (WWTPs) are known to be point sources of micropollutants for surface waters. The aim of this study was to examine a reconstructed full-scale ozonation equipped with a pump-injector system for ozone (O3) dosage and a fluidized moving-bed reactor as biological posttreatment at a municipal WWTP utilizing an effect-directed approach. This approach consists of chemical analysis in combination with toxicological tests for the assessment of treatment efficiency of the plant...
September 7, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28880749/exposure-to-decabromodiphenyl-ether-bde-209-produces-mitochondrial-dysfunction-in-rat-liver-and-cell-death
#18
Lilian C Pereira, Alecsandra O Souza, Maria J Tasso, Alana M C Oliveira, Filipe V Duarte, Carlos M Palmeira, Daniel J Dorta
Polybrominated diphenyl ethers (PBDE) are ubiquitous environmental pollutants. Exposure to these chemicals has been associated with developmental neurotoxicity, endocrine dysfunctions, reproductive disorders, and hepatotoxicity. The widespread use of PBDE as flame retardants has culminated in daily exposure of humans and wildlife to these contaminants and resulted in their banned use. Thus assessment of the potential effects of each PBDE congener on living organisms has become cause for concern. The aim of this study was to (1) examine the effects of decabromodiphenyl ether (BDE)-209 on different functions of HepG2 cells and (2) investigate whether this congener is involved in mitochondrial toxicity...
September 7, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28880744/the-effects-of-phenylethanoid-glycosides-derived-from-herba-cistanche-on-cognitive-deficits-and-antioxidant-activities-in-male-samp8-mice
#19
Jian-Xin Jia, Xu-Sheng Yan, Zhi-Ping Cai, Wei Song, Dong-Sheng Huo, Bai-Feng Zhang, He Wang, Zhan-Jun Yang
Cognitive deficits are closely associated with hippocampal synaptic changes. Phenylethanoid glycosides (PhG), derived from Herba cistanche, are known to exert protective effects on cognitive deficits in Alzheimer's disease (AD); however, the underlying mechanisms of this herbal extract on cognitive performance remain unclear. The aim of this study was thus to examine the protective mechanism attributed to PhG on cognitive deficits in an AD senescence accelerated mouse prone 8 (SAMP8) model. Cognitive deficit parameters examined included (1) Morris water maze (MWM) assessing cognitive performance and (2) quantification of dendritic spine density in hippocampal CA1 region by Golgi staining, a molecular biomarker of synaptic function...
September 7, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28880739/methionine-supplemented-diet-affects-the-expression-of-cardiovascular-disease-related-genes-and-increases-inflammatory-cytokines-in-mice-heart-and-liver
#20
Alexandre Ferro Aissa, Catia Lira do Amaral, Vinicius Paula Venancio, Carla da Silva Machado, Lívia Cristina Hernandes, Patrick Wellington da Silva Santos, Rui Curi, Maria de Lourdes Pires Bianchi, Lusânia Maria Greggi Antunes
Some important environmental factors that influence the development of cardiovascular diseases (CVD) include tobacco, excess alcohol, and unhealthy diet. Methionine obtained from the diet participates in the synthesis of DNA, proteins, lipids and affects homocysteine levels, which is associated with the elevated risk for CVD development. Therefore, the aim of this study was to investigate the manner in which dietary methionine might affect cellular mechanisms underlying CVD occurrence. Swiss albino mice were fed either control (0...
September 7, 2017: Journal of Toxicology and Environmental Health. Part A
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