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Journal of Toxicology and Environmental Health. Part A

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https://www.readbyqxmd.com/read/30430930/analysis-of-long-non-coding-rna-profiled-following-mc-lr-induced-hepatotoxicity-using-high-throughput-sequencing
#1
Cong Wen, Shu Yang, Shuilin Zheng, Xiangling Feng, Jihua Chen, Fei Yang
The occurrence of microcystin-LR(MC-LR) variant a known hepatotoxin constitutes a global public health concern. However, the molecular mechanisms underlying MC-LR-induced hepatotoxicity remain to be determined. The aim of this study was to investigate whether long noncoding RNAs (lncRNA) were involved in MC-LR-mediated hepatotoxicity using human normal liver cell line HL7702 to profile lncRNAs after 24 hr treatment with MC-LR. With the use of high-throughput sequencing techniques, data showed that the expression levels of 37, 33, 34, 35 lncRNA were significantly altered following exposure to 1, 2...
November 15, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/30430926/isolation-molecular-identification-and-characterization-of-a-unique-toxic-cyanobacterium-microcystis-sp-found-in-hunan-province-china
#2
Pin Liu, Jia Wei, Kun Yang, Isaac Yaw Massey, Jian Guo, Chengcheng Zhang, Fei Yang
Global proliferation of cyanobacterial blooms associated with climate change and eutrophication constitutes a serious environmental threat. In Hunan Province a freshwater pond located in Changsha City was found to contain high concentrations of cyanobacteria, however, the characteristics of these cyanobacteria at present are not known. This study thus aimed to isolate, identify the most common bloom-forming cyanobacteria in this region and determine the toxigenic characteristics of the predominant cyanobacteria...
November 15, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/30430925/the-protective-mechanism-underlying-phenylethanoid-glycosides-phg-actions-on-synaptic-plasticity-in-rat-alzheimer-s-disease-model-induced-by-beta-amyloid-1-42
#3
Jian-Xin Jia, Xu-Sheng Yan, Wei Song, Xin Fang, Zhi-Ping Cai, Dong-Sheng Huo, He Wang, Zhan-Jun Yang
Phenylethanoid glycosides (PHG), derived from Herba cistanche, were found to exert protective effects on cognitive dysfunctions by improving synaptic plasticity in Alzheimer's disease (AD) rat model. However, the mechanisms underlying these effects of PHG on synaptic plasticity remain to be determined. Thus the aim of this study was to examine the influence of PHG on synaptic plasticity in male AD rat model induced by bilateral central nervous system ventricle injections of beta amyloid 1-42 oligomers (Aβ1-42)...
November 15, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/30430924/the-protective-mechanism-underlying-total-flavones-of-dracocephalum-tfd-effects-on-rat-cerebral-ischemia-reperfusion-injury
#4
Peng Wu, Xu-Sheng Yan, Yu Zhang, Dong-Sheng Huo, Wei Song, Xin Fang, He Wang, Zhan-Jun Yang, Jian-Xin Jia
Previously, total flavones of Dracocephalum (TFD), derived from Dracocephalum, were found to exert protective effects in cerebral ischemia reperfusion injury (CIRI) in middle cerebral artery occlusion (MCAO) rat model. However, the mechanisms underlying these observed effects of TFD on MCAO-induced rats still remain to be determined. Therefore, the aim of this study was to examine whether TFD alleviated MCAO through mechanisms involving anti-inflammatory and anti-apoptotic using MCAO rats. The following parameters were measured: (1) percentage (%) area of brain infarction; (2) serum levels of inflammatory cytokines, including tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) and (3) expression protein levels of caspase-3 and AMP-activated protein kinase (AMPK)...
November 15, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/30430919/involvement-of-nerve-growth-factor-in-mouse-hippocampal-neuronal-cell-line-ht22-differentiation-and-underlying-role-of-dna-methyltransferases
#5
Ming Zhang, Hongxia Zheng, Xiaolu Zhang, Xiaoli Tian, Shengdi Xu, You Liu, Shuyuan Jiang, Xiaolei Liu, Rui Shi, Kerui Gong, Shaochun Yan, He Wang, Guo Shao, Zhanjun Yang
DNA methylation is an epigenetic event involved in regulation of gene transcription during cell differentiation. DNA methyltransferases (DNMT) play a role in differentiation of neural stem cells into neurons. The aim of this study was to determine whether nerve growth factor (NGF) was involved in differentiation of mouse hippocampal neuronal cell line (HT22) as assessed by IncuCyte. Quantitative PCR and western blot were used to measure gene and protein expression of DNMT as well as the activity of DNMTs. Treatment with NGF was found to upregulate both gene and protein expressions as well as total activity of DNMTs in differentiating HT22 cells...
November 15, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/30422063/involvement-of-mapk-erk1-2-pathway-in-microcystin-induced-microfilament-reorganization-in-hl7702-hepatocytes
#6
Fei Yang, Cong Wen, Shuilin Zheng, Shu Yang, Jihua Chen, Xiangling Feng
Several studies previously demonstrated that microcystin (MC)-LR produced cytoskeletal damage, especially to actin filaments. However, the underlying mechanisms of MC-induced cytoskeletal reorganization remain to be determined. The aim of this study was to examine the effects of 5 or 10 µM MC-LR on microfilament depolarization and expression of microRNA-451a (miR-451a) which plays a crucial role in cellular processes including cell proliferation, apoptosis and tumorigenesis in HL7702 liver cells after 24 hr treatment...
November 13, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/30418797/gender-specific-associations-between-polymorphisms-in-the-toll-like-receptor-tlr-genes-and-lung-function-among-workers-in-swine-operations
#7
Zhiwei Gao, James A Dosman, Donna C Rennie, David A Schwartz, Ivana V Yang, Jeremy Beach, Ambikaipakan Senthilselvan
Workers in swine operations are exposed to dust, bacteria, and virus, and are at increased risk of respiratory problems. Toll-like receptors (TLR) play an important role in human immune responses to respiratory hazards. Worker gender and age may significantly modify the involvement of TLR in the etiology of these respiratory outcomes. The aim of this study was to investigate whether modification effects of worker gender and age altered associations between polymorphisms in the TLR genes and lung function. This study included 374 full-time workers from large swine operations from Saskatchewan...
November 12, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/30415634/determination-of-fragrance-allergens-and-their-dermal-sensitization-quantitative-risk-assessment-qra-in-107-spray-perfumes
#8
Duck Soo Lim, Seul Min Choi, Kyu-Bong Kim, Kyungsil Yoon, Sam Kacew, Hyung Sik Kim, Byung-Mu Lee
Cutaneous allergy occurs primarily as a result of using cosmetic, household, and laundry products available on the market that contain fragrances. The aim of this study was to develop a rapid and specific high-performance liquid chromatography with ultraviolet detection (HPLC-UV) method for quantification of 25 fragrance allergens (amyl cinnamyl alcohol, benzyl alcohol, benzyl benzoate, benzyl cinnamate, benzyl salicylate, citronellol, cinnamyl alcohol, citral, coumarin, eugenol, farnesol, geraniol, hydroxycitronellal, HICC (4-(4-hydroxy-4-methylpentyl)-3-cyclohexene-1-carboaldehyde), isoeugenol, isoeugenyl acetate, lilial (butyl phenyl methyl propional), limonene, linalool, methyl 2-octynoate, etc...
November 12, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/30415604/risk-assessment-of-endocrine-disrupting-phthalates-and-hormonal-alterations-in-children-and-adolescents
#9
Dong Hyun Kim, Seul Min Choi, Duck Soo Lim, Taehyun Roh, Seung Jun Kwack, Sungpil Yoon, Min Kook Kim, Kyung Sil Yoon, Hyung Sik Kim, Dong Wook Kim, Byung-Mu Lee
Risk assessment and hormone evaluation were carried out for di(2-ethylhexyl) phthalate (DEHP) and dibutyl phthalate (DBP), endocrine disrupting chemicals (EDCs), in 302 Korean children (n = 223) and adolescents (n = 79) (< age 19). Urinary and serum concentrations of DEHP, MEHP (mono(2-ethylhexyl) phthalate), DBP, MBP (monobutyl phthalate), and PA (phthalic acid, a common final metabolite of phthalates) were detected in children and adolescents. Daily exposure levels were estimated to be 16.45 ± 36...
November 12, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/30388930/essential-and-toxic-elements-in-honeys-consumed-in-italy
#10
Maria Assunta Meli, Ivan Fagiolino, Donatella Desideri, Carla Roselli
The aim of this study was to determine the levels of iron (Fe), manganese (Mn), chromium (Cr), copper (Cu), zinc (Zn), mercury (Hg), cadmium (Cd) and lead (Pb) in several types of honey purchased from the local consumer markets in Central Italy by Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Lead and Cd were also determined by Atomic Absorption Spectrometry with graphite tube atomization (AAS-GTA). The degree of humidity, sugar content, pH, free acidity, combined acidity (lactones) and total acidity were also measured...
November 2, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/30373484/surveillance-results-and-bone-effects-in-the-gulf-war-depleted-uranium-exposed-cohort
#11
Melissa A McDiarmid, Marianne Cloeren, Joanna M Gaitens, Stella Hines, Elizabeth Streeten, Richard J Breyer, Clayton H Brown, Marian Condon, Tracy Roth, Marc Oliver, Lawrence Brown, Moira Dux, Michael R Lewin-Smith, Frederick Strathmann, Maria A Velez-Quinones, Patricia Gucer
A small group of Gulf War I veterans wounded in depleted uranium (DU) friendly-fire incidents have been monitored in a clinical surveillance program since 1993. During the spring of 2017, 42 members of the cohort were evaluated with a protocol which includes exposure monitoring for total and isotopic uranium concentrations in urine and a comprehensive assessment of health outcomes including measures of bone metabolism, and for participants >50 years, bone mineral density (BMD) determination. Elevated urine U concentrations were observed in cohort members with retained DU shrapnel fragments...
October 29, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/30365389/reverse-dosimetry-modeling-of-toluene-exposure-concentrations-based-on-biomonitoring-levels-from-the-canadian-health-measures-survey
#12
Honesty Tohon, Andy Nong, Marjory Moreau, Mathieu Valcke, Sami Haddad
Biomonitoring might provide useful estimates of population exposure to environmental chemicals. However, data uncertainties stemming from interindividual variability are common in large population biomonitoring surveys. Physiologically based pharmacokinetic (PBPK) models might be used to account for age- and gender-related variability in internal dose. The objective of this study was to reconstruct air concentrations consistent with blood toluene measures reported in the third Canadian Health Measures Survey using reverse dosimetry PBPK modeling techniques...
October 26, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/30303455/ecotoxicological-risk-assessment-of-contaminated-soil-from-a-complex-of-ceramic-industries-using-earthworm-eisenia-fetida
#13
Ana Paula Oliveira Resende, Vanessa Santana Vieira Santos, Carlos Fernando Campos, Cássio Resende de Morais, Edimar Olegario de Campos Júnior, Antônio Marcos Machado de Oliveira, Boscolli Barbosa Pereira
The aim of this study was to determine ecotoxicological parameters for biomonitoring of environmental risk of native soils from a ceramic industrial area that had been contaminated with cadmium (Cd) and chromium (Cr) by using the earthworm, Eisenia fetida. Initially, lab tests were conducted to compare earthworm (Eisenia fetida) growth, survival, morphology, behavior, and reproduction rates following exposure to six concentrations of contaminated soil at 0%, 6.25%, 12.5%, 25%, 50%, or 100% mixed in artificial soil and cow dung following a 28-d incubation period...
October 10, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/30239325/assessing-ototoxicity-due-to-chronic-lead-and-cadmium-intake-with-and-without-noise-exposure-in-the-mature-mouse
#14
Krystin Carlson, Jochen Schacht, Richard L Neitzel
Exposure to heavy metals may lead to hearing impairment. However, experimental studies have not explored this issue with and without noise exposure in mature animals with environmentally relevant doses. The aim of this study was to investigate ototoxicity produced by lead (Pb) and cadmium (Cd) and noise, singly and in combination, in the adult CBA/CaJ mouse. Metals were delivered via drinking water (0.03 mM, 1 mM, and 3 mM Pb; or 30, 100, and 300 μM Cd) for 12 weeks, resulting in environmentally- and occupationally relevant mean (± standard deviations) blood levels of Pb (2...
September 21, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/30239279/oxidative-stress-response-to-air-particle-pollution-in-a-rat-nutritional-growth-retardation-model
#15
Melisa L Kurtz, Francisco Astort, Christian Lezon, Sebastián A Ferraro, Guillermo A Maglione, Nadia S Orona, Silvia M Friedman, Patricia M Boyer, Deborah R Tasat
Air pollution consisting of gases and particulate matter-(PM) represents a health problem in cities worldwide. However, air pollution does not impact equally all individuals, as children appear to be more vulnerable subpopulations. Air pollution and malnutrition are two distinct factors that have been associated with oxidative damage. Therefore, the interaction between environmental exposure and nutritional status in populations at risk needs to be explored. The aim of this study was to examine oxidative metabolism in lung, heart and liver in malnourished young rats exposed to residual oil fly ash (ROFA)...
September 21, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/30230972/application-of-the-adverse-outcome-pathway-aop-approach-to-inform-mode-of-action-moa-a-case-study-with-inorganic-arsenic
#16
Harvey J Clewell, Janice W Yager, Tracy B Greene, P Robinan Gentry
The aim of this study was to establish a process for deriving a chemical-specific mode of action (MOA) from chemical-agnostic adverse outcome pathway (AOPs), using inorganic arsenic (iAs) as a case study. The AOP developed for this case study are related to disruption of cellular signaling by chemicals that strongly bind to vicinal dithiols in cellular proteins, leading to disruption of inflammatory and oxidative stress signaling along with inhibition of the DNA damage responses. The proposed MOA for iAs incorporates this AOP, overlaid on a background of increasing oxidative stress and/or co-exposure to mutagenic chemicals or radiation...
September 19, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/30156999/searching-for-antigenotoxic-properties-of-marine-macroalgae-dietary-supplementation-against-endogenous-and-exogenous-challenges
#17
Ana Marques, João Ferreira, Helena Abreu, Rui Pereira, Andreia Rego, João Serôdio, Gregor Christa, Isabel Gaivão, Mário Pacheco
The functional characterization of marine macroalgae toward their potential to strength genome protection is still scarce. Hence, the aim of this study was to assess the antigenotoxic potential of Ulva rigida, Fucus vesiculosus, and Gracilaria species in Drosophila melanogaster following dietary exposure and adopting the somatic mutation and recombination test (SMART). All macroalgae displayed a genoprotection activity, namely against an exogenous challenge (streptonigrin). The action against subtler endogenous pressures was also noted indicating that supplementation level is a critical factor...
August 29, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/30130461/intestinal-metabolism-and-bioaccumulation-of-sucralose-in-adipose-tissue-in-the-rat
#18
Volker Bornemann, Stephen C Werness, Lauren Buslinger, Susan S Schiffman
The aim of this study was to (1) determine if the organochlorine artificial sweetener sucralose is metabolized in rat intestine with repeated dosing and (2) examine whether sucralose might bioaccumulate in rat adipose tissue. Sucralose was administered to 10 rats by gavage daily for 40 days at an average dosage of 80.4 mg/kg/day. The dosages were within the range utilized in historical toxicology studies submitted for regulatory approval in North America, Europe, and Asia. Feces and urine were collected individually from each animal for every 24-hr period during the 40-day dosing period...
August 21, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/30102137/using-morphological-behavioral-and-molecular-biomarkers-in-zebrafish-to-assess-the-toxicity-of-lead-contaminated-sediments-from-a-retired-trapshooting-range-within-an-urban-wetland
#19
Alex J Olson, Trevor Cyphers, Gretchen Gerrish, Colin Belby, Tisha C King-Heiden
The widespread use of lead (Pb) shot in shooting activities, including at former shooting ranges, continues to pose environmental risks. The La Crosse River Marsh (located in Wisconsin, USA) is a biologically diverse urban riparian wetland with a legacy of Pb-contaminated sediment resulting from its use as a trap shooting range from 1929-1963. Within the shot fall zone, shot densities exceed 43,000 pellets/m2 and surface sediments exceed 25,000 mg/kg in some areas. This study used the Zebrafish as a model to determine the acute toxicity of these contaminated sediments...
August 13, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/30325712/the-genotoxic-effects-of-fruit-extract-of-crataegus-oxyacantha-hawthorn-in-mice
#20
Bruna Thiemi Yonekubo, Heloisa de Miranda Cantuaria Alves, Eduardo de Souza Marques, Fábio Ferreira Perazzo, Paulo César Pires Rosa, Isabel O'Neill de Mascarenhas Gaivão, Edson Luis Maistro
Crataegus oxyacantha L. (Rosaceae) is a medicinal plant with a long history of use in European, Chinese, and American. The majority of pharmacological activities associated with fruit extracts of C. oxyacantha L. are related to cardio-stimulant properties utilized in the treatment of atherosclerosis, hypertension with myocardic insufficiency, angina pectoris, cardiac rhythm alterations, and heart failure. Some other therapeutic uses for renal calculi, dyspnea, as well as a diuretic, sedative, and anxiolytic were also reported...
2018: Journal of Toxicology and Environmental Health. Part A
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