journal
MENU ▼
Read by QxMD icon Read
search

Journal of Toxicology and Environmental Health. Part A

journal
https://www.readbyqxmd.com/read/28708459/the-combined-effect-of-macondo-oil-and-corexit-on-sheepshead-minnow-cyprinodon-variegatus-during-early-development
#1
Thijs Bosker, Liselotte van Balen, Brid Walsh, Marisol S Sepúlveda, Sylvain DeGuise, Chris Perkins, Robert J Griffitt
During the 2010 Deepwater Horizon (DWH), oil spill an estimated 800 million L oil and 7.9 million L dispersant entered the environment. The potential adverse effects of the oil-dispersant mixture are poorly understood. The aim of this study was to investigate the impacts of this mixture on early development of sheepshead minnow (Cyprinodon variegatus), a small-bodied estuarine fish commonly found in the area affected by the DWH spill. Embryos were exposed to a chemically enhanced water accommodated fraction (CEWAF; 10:1 mixture of Macondo oil; Corexit 9500) for 48 hr, after which organisms were maintained in uncontaminated water for an additional 8 days...
July 14, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28696918/gold-nanorods-induce-early-embryonic-developmental-delay-and-lethality-in-zebrafish-danio-rerio
#2
Bárbara Mesquita, Isabel Lopes, Susana Silva, Maria João Bessa, Maksim Starykevich, Jorge Carneiro, Tiago L P Galvão, Mário G S Ferreira, João Tedim, João Paulo Teixeira, Sónia Fraga
Due to their unique electronic and optical features, gold nanoparticles (AuNP) have received a great deal of attention for application in different fields such as catalysis, electronics, and biomedicine. The large-volume manufacturing predicted for future decades and the inevitable release of these substances into the environment necessitated an assessment of potential adverse human and ecological risks due to exposure to AuNP. Accordingly, this study aimed to examine the acute and developmental toxicity attributed to a commercial suspension of Au nanorods stabilized with cetyltrimethylammonium bromide (CTAB-AuNR) using early embryonic stages of zebrafish (Danio rerio), a well-established model in ecotoxicology...
July 11, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28696914/micro-brushing-based-technique-to-gain-fresh-urothelial-cells-for-gene-expression-analysis
#3
Christoph Kuhn, Marie-Louise Lehmann, Alexander Kress, Michael C Truß, Matthias Hermes, Meinolf Blaszkewicz, Jan G Hengstler, Klaus Golka
The gold standard of saving fresh tissue in liquid nitrogen has some serious disadvantages in that this process is not available in daily medical routine practices even in many tumor centers. Our approach of a new minimally invasive technique is obtaining urothelial cells via micro-brushing the urinary bladder on the occasion of urological routine methods such as transurethral resection (TUR). Urothelial cells were obtained from 25 patients via two different micro-brushes from tumor tissue and from macroscopically healthy tissue during TUR...
July 11, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28696913/linking-physiological-parameters-to-perturbations-in-the-human-exposome-environmental-exposures-modify-blood-pressure-and-lung-function-via-inflammatory-cytokine-pathway
#4
Matthew A Stiegel, Joachim D Pleil, Jon R Sobus, Tina Stevens, Michael C Madden
Human biomonitoring is an indispensable tool for evaluating the systemic effects derived from external stressors including environmental pollutants, chemicals from consumer products, and pharmaceuticals. The aim of this study was to explore consequences of environmental exposures to diesel exhaust (DE) and ozone (O3) and ultimately to interpret these parameters from the perspective of in vitro to in vivo extrapolation. In particular, the objective was to use cytokine expression at the cellular level as a biomarker for physiological systemic responses such as blood pressure and lung function at the systemic level...
July 11, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28696911/n-acetyltransferase-1-10-genotype-in-bladder-cancer-patients
#5
Svetlana Höhne, Holger Gerullis, Meinolf Blaszkewicz, Silvia Selinski, Jan G Hengstler, Thomas Otto, Klaus Golka
In a large bladder cancer study in the greater Berlin area with 425 cases and 343 controls, the haplotype N-acetyltransferase 1*10 (NAT1*10) was associated with a decreased bladder cancer risk. In a recently published meta-analysis, results of the studies were found to be inconclusive. Therefore, the aim of this study was to investigate the frequency of NAT1*10 in bladder cancer patients and controls recruited in an area without industries reported to be associated with increased bladder cancer risk. Rs1057126 (1088 T > A) and rs15561 (1095 C > A) were determined in 412 bladder cancer patients and 415 controls without a known history of malignancies...
July 11, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28696905/protection-during-production-problems-due-to-prevention-nail-and-skin-condition-after-prolonged-wearing-of-occlusive-gloves
#6
Wobbeke Weistenhöfer, Wolfgang Uter, Hans Drexler
Wearing of occlusive gloves during the whole working shift is considered a risk factor for developing hand eczema, similar to wet work. Moreover, the increased hydration due to glove occlusion may lead to brittle nails. Two hundred and seventy clean room workers, wearing occlusive gloves for prolonged periods, and 135 administrative employees not using gloves were investigated. This included a dermatological examination of the nails and the hands, using the Hand Eczema ScoRe for Occupational Screening (HEROS), measurement of transepidermal water loss (TEWL), and a standardized interview...
July 11, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28696897/polymorphisms-of-xenobiotic-metabolizing-enzymes-in-bladder-cancer-patients-of-the-semmelweis-university-budapest-hungary
#7
Dörte Ebbinghaus, Gergely Bánfi, Silvia Selinski, Meinolf Blaszkewicz, Hannah Bürger, Jan G Hengstler, Péter Nyirády, Klaus Golka
Polymorphic xenobiotic metabolizing enzymes such as N-acetyltransferase 2 (NAT2) or glutathione S-transferase M1 (GSTM1) are known to modulate bladder cancer risk. As no apparent data were available from Hungary, a former member of the eastern European economic organization, a study was performed in Budapest. In total, 182 bladder cancer cases and 78 cancer-free controls were investigated by questionnaire. Genotypes of NAT2, GSTM1, GSTT1, rs1058396 and rs17674580 were determined by standard methods. Current smokers' crude odds ratio (OR) (3...
July 11, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28696896/assessment-of-dna-damage-in-a-group-of-professional-dancers-during-a-10-month-dancing-season
#8
Filipa Esteves, Eduardo Teixeira, Tânia Amorim, Carla Costa, Cristiana Pereira, Sónia Fraga, Vanessa Moraes De Andrade, João Paulo Teixeira, Solange Costa
Despite the numerous health benefits of physical activity, some studies reported that increased intensity and duration may induce oxidative stress in several cellular components including DNA. The aim of this study was to assess the level of basal DNA damage as well as oxidative DNA damage in a group of professional dancers before and after a 10-month dancing season. A group of individuals from general population was also assessed as a control. The alkaline version of the comet assay was the method selected to measure both basal DNA damage and oxidative stress, since this method quantifies both endpoints...
July 11, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28696895/urinary-bladder-cancer-risk-factors-in-an-area-of-former-coal-iron-and-steel-industries-in-germany
#9
Eugen Krech, Silvia Selinski, Meinolf Blaszkewicz, Hannah Bürger, Thura Kadhum, Jan G Hengstler, Michael C Truß, Klaus Golka
This study was performed to investigate the frequency of bladder cancer in patients with an occupational history such as underground hard coal mining and/or painting after the structural change in the local industry. A total of 206 patients with bladder cancer and 207 controls were enlisted regarding occupational and nonoccupational bladder cancer risk factors by questionnaire. The phase II enzymes N-acetyltransferase 2 (NAT2), glutathione S-transferases M1 (GSTM1), and T1 (GSTT1) and the single nucleotide polymorphism (SNP) rs11892031[A/C] reported to be associated with bladder cancer in genome-wide association studies were genotyped...
July 11, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28696839/occupational-bladder-cancer-polymorphisms-of-xenobiotic-metabolizing-enzymes-exposures-and-prognosis
#10
Cordula Lukas, Silvia Selinski, Hans-Martin Prager, Meinolf Blaszkewicz, Jan G Hengstler, Klaus Golka
Approximately 7% of all bladder cancer cases in males are associated with occupation. The question arises whether the use of genome-wide association studies was able to identify bladder cancer risk factors that may modulate occupational bladder cancer risk and prognosis. One hundred and forty-three bladder cancer cases with suspected occupational bladder cancer and 337 controls were genotyped for the following polymorphisms: N-acetyltransferase 2 (NAT2), glutathione S-transferase M1 (GSTM1), glutathione S-transferase T1 (GSTT1), UDP-glucuronyltransferase 1A rs11892031 (UGT1A), rs9642880 (close to c-MYC), and rs710521 (close to TP63)...
July 11, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28696837/japanese-quail-coturnix-japonica-liver-and-thyroid-gland-histopathology-as-a-result-of-in-ovo-exposure-to-the-flame-retardants-tris-1-3-dichloro-2-propyl-phosphate-and-dechlorane-plus
#11
Mona L Jacobsen, Veerle L B Jaspers, Tomasz M Ciesielski, Bjørn M Jenssen, Mari E Løseth, Nathalie Briels, Igor Eulaers, Páll S Leifsson, Frank F Rigét, Pilar Gomez-Ramirez, Christian Sonne
Japanese quails (Coturnix japonica) were exposed in ovo to tris(1,3-dichloro-2-propyl) phosphate (TDCIPP; 500 ng/µl), Dechlorane Plus (DP; 500 ng/µl), or a 1:1 mixture of these two to investigate the effects on liver and thyroid gland morphology. Histological examination of 14-day-old quails showed that exposure to TDCIPP or the mixture induced hepatic sinusoidal dilatation. No marked effects were seen for DP alone. In addition, the mixture produced divergence of thyroid gland follicles and proliferation of follicular cells...
July 11, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28696835/urinary-cadmium-levels-in-active-and-retired-coal-miners
#12
Julia Isermann, Hans-Martin Prager, Rainer Ebbinghaus, Beata Janasik, Wojciech Wasowicz, Bertinus Dufaux, Hans-Friedrich Meyer, Agata Widera, Silvia Selinski, Jan G Hengstler, Klaus Golka
A meta-analysis, based upon 24 publications, showed a significantly elevated risk for urinary bladder cancer amongst miners. In European underground hard coal mining areas, an increased risk for urinary bladder cancer development was noted among hard coal miners, in particular in three investigations in the greater Dortmund area. However, the cause remains unclear. As cadmium (Cd), which was reported to be a bladder carcinogen in humans and is a constituent of coal, the aim of this study was to determine urinary Cd levels in active and retired hard coal miners and assess whether hard coal miners demonstrated elevated metal levels...
July 11, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28696834/simultaneous-detection-of-the-tetrachloroethylene-metabolites-s-1-2-2-trichlorovinyl-glutathione-s-1-2-2-trichlorovinyl-l-cysteine-and-n-acetyl-s-1-2-2-trichlorovinyl-l-cysteine-in-multiple-mouse-tissues-via-ultra-high-performance-liquid-chromatography-electrospray
#13
Yu-Syuan Luo, Joseph A Cichocki, Thomas J McDonald, Ivan Rusyn
Tetrachloroethylene (perchloroethylene; PERC) is a high-production volume chemical and ubiquitous environmental contaminant that is hazardous to human health. Toxicity attributed to PERC is mediated through oxidative and glutathione (GSH) conjugation metabolites. The conjugation of PERC by glutathione-s-transferase to generate S-(1,2,2-trichlorovinyl) glutathione (TCVG), which is subsequently metabolized to form S-(1,2,2-trichlorovinyl)-L-cysteine (TCVC) is of special importance to human health. Specifically, TCVC may be metabolized to N-acetyl-S-(1,2,2-trichlorovinyl)-L-cysteine (NAcTCVC) which is excreted through urine, or to electrophilic metabolites that are nephrotoxic and mutagenic...
July 11, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28682217/simvastatin-modulates-gene-expression-of-key-receptors-in-zebrafish-embryos
#14
V Cunha, M M Santos, P Moradas-Ferreira, L F C Castro, M Ferreira
Nuclear receptors (NR) are involved in the regulation of several metabolic processes and it is well known that these constituents may be modulated by different chemicals classes, including pharmaceuticals that may activate or antagonize NR. In mammals, some pharmaceuticals modulate the transcription of pregnane X receptor, Pxr, peroxisome proliferator activated receptor, Ppars, and aryl hydrocarbon receptor, Ahr, affecting mRNA expression of genes belonging to various regulatory pathways, including lipid metabolism and detoxification mechanisms...
July 6, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28679081/polycyclic-aromatic-hydrocarbons-pah-in-portuguese-educational-settings-a-comparison-between-preschools-and-elementary-schools
#15
Klara Slezakova, Marta Oliveira, Joana Madureira, Eduardo de Oliveira Fernandes, Cristina Delerue-Matos, Simone Morais, Maria do Carmo Pereira
The aim of this study was to determine levels and risks due to inhalation exposure to polycyclic aromatic hydrocarbons (PAH) in different educational settings, namely for 3- to 5- year-old and 6- to 10-year-old children. Eighteen PAH (16 priority designated by US Environmental Protection Agency (USEPA) and dibenzo[a,l]pyrene and benzo[j]fluoranthene) were simultaneously collected in indoor and outdoor air at two Portuguese preschools (PS1-PS2) and five elementary schools (ES1-ES5) from March to May 2014. Indoor concentrations at PS and ES were significantly different, with total levels (∑PAHs) 0...
July 5, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28665768/identification-of-a-sensitive-urinary-biomarker-selenium-binding-protein-1-for-early-detection-of-acute-kidney-injury
#16
Kyeong Seok Kim, Hun Yong Yang, Hosup Song, Ye Rim Kang, JiHoon Kwon, JiHye An, Ji Yeon Son, Seung Jun Kwack, Young-Mi Kim, Ok-Nam Bae, Mee-Young Ahn, Jaewon Lee, Sungpil Yoon, Byung Mu Lee, Hyung Sik Kim
Acute kidney injury (AKI) is associated with increased mortality rate in patients but clinically available biomarkers for disease detection are currently not available. Recently, a new biomarker, selenium-binding protein 1 (SBP1), was identified for detection of nephrotoxicity using proteomic analysis. The aim of this study was to assess the sensitivity of urinary SBP1 levels as an early detection of AKI using animal models such as cisplatin or ischemia/reperfusion (I/R). Sprague-Dawley rats were injected with cisplatin (6 mg/kg, once i...
June 30, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28644718/third-symposium-on-interdisciplinary-activities-in-environmental-toxicology-in-north-rhine-westphalia-germany
#17
Klaus Golka, Katja Ickstadt, Silvia Selinski, Jan G Hengstler, Michael Wilhelm
No abstract text is available yet for this article.
June 23, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28569646/mapping-exposure-to-multi-pollutants-using-environmental-biomonitors-a-multi-exposure-index
#18
Helena C Serrano, Melanie Köbel, José Palma-Oliveira, Pedro Pinho, Cristina Branquinho
Atmosphere is a major pathway for transport and deposition of pollutants in the environment. In industrial areas, organic compounds are released or formed as by-products, such as polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/F's). Inorganic chemical elements, including lead and arsenic, are also part of the pollutants mixture, and even in low concentrations may potentially be toxic and carcinogenic. However, assessing the spatial pattern of their deposition is difficult due to high spatial and temporal heterogeneity...
June 1, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28569620/indoor-air-quality-in-preschools-3-to-5-year-old-children-in-the-northeast-of-portugal-during-spring-summer-season-pollutants-and-comfort-parameters
#19
Marta Oliveira, Klara Slezakova, Cristina Delerue-Matos, Maria do Carmo Pereira, Simone Morais
Indoor air quality at schools (elementary, primary) has been the subject of many studies; however, there are still relative few data regarding preschool (3- to 5-year-old children) environments. This investigation determined the concentrations of particulate matter (PM)2.5, total volatile organic compounds (TVOC), formaldehyde, carbon monoxide (CO), and ozone (O3) as well as the levels of carbon dioxide (CO2), temperature, and relative humidity (RH) in the indoor and outdoor air of two preschools situated in different geographical regions of Portugal...
June 1, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28548622/fungal-contamination-in-green-coffee-beans-samples-a-public-health-concern
#20
Carla Viegas, Cátia Pacífico, Tiago Faria, Ana Cebola de Oliveira, Liliana Aranha Caetano, Elisabete Carolino, Anita Quintal Gomes, Susana Viegas
Studies on the microbiology of coffee cherries and beans have shown that the predominant toxigenic fungal genera (Aspergillus and Penicillium) are natural coffee contaminants. The aim of this study was to investigate the distribution of fungi in Coffea arabica L. (Arabica coffee) and Coffea canephora L. var. robusta (Robusta coffee) green coffee samples obtained from different sources at the pre-roasting stage. Twenty-eight green coffee samples from different countries of origin (Brazil, Timor, Honduras, Angola, Vietnam, Costa Rica, Colombia, Guatemala, Nicaragua, India, and Uganda) were evaluated...
May 26, 2017: Journal of Toxicology and Environmental Health. Part A
journal
journal
35121
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"