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Current Drug Metabolism

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https://www.readbyqxmd.com/read/28933269/drug-delivery-and-cosmeceutical-applications-of-polylactic-acid-based-novel-constructs-a-review
#1
Hafiz M N Iqbal, Federico Ruiz-Ruiz, Elena Ivonne Mancera-Andrade, Roberto Parra-Saldivar, Tajalli Keshavarz
In recent years, there has been a great research interest in bio-based biopolymers due to their potential as alternative polymers to the traditional petroleum-based synthetic counterparts. Research is underway around the globe on the development of 'greener' technologies. Recently, bio-based bio-constructs are being engineered for target applications in different bio- and non-bio sectors of the modern world to address growing concerns of a global dependence on non-renewable petroleum-based resources. The utilization of properly designed and structured materials thus allows for the creation of well-defined environment that induces a series of directed measures, and so on...
September 19, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28901254/therapeutics-and-immunoprophylaxis-against-noroviruses-and-rotaviruses
#2
Souvik Ghosh, Yashpal Singh Malik, Nobumichi Kobayashi
Noroviruses and rotaviruses are important viral etiologies of severe gastroenteritis. Noroviruses are the primary cause of non-bacterial diarrheal outbreaks in humans, whilst rotaviruses are a major cause of childhood diarrhea. Although both enteric pathogens substantially impact human health and economies, there are no approved drugs against noroviruses and rotaviruses, so far. On the other hand, whilst the currently licensed rotavirus vaccines have been successfully implemented in over 100 countries, the most advanced norovirus vaccine has recently completed phase-I and II trials...
September 12, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28901255/health-benefits-of-manuka-honey-as-an-essential-constituent-for-tissue-regeneration
#3
Kamal Niaz, Faheem Maqbool, Haji Bahadar, Mohammad Abdollahi
Honey is known for its therapeutic properties from ancient civilizations but only since last few decades its mechanism has been studied on how it causes epithelial regeneration leading to wound and ulcer healing.. In the present review the health perspectives of honey, its chemical composition with special reference to flavonoids, polyphenol composition and other bioactive trace compounds used in tissue regeneration have been highlighted. Honey can inhibit carcinogenesis by moderating with molecular processes of initiation, advancement and progression stage of cancer cells, therefore it is considered a promising anti-cancer agent...
September 11, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28901253/bacterial-toxins-a-hope-towards-angiogenic-ailments
#4
Rekha Khandia, Ashok Kumar Munjal, Kuldeep Dhama, Yashpal Singh Malik
Angiogenesis is a vital physiological process essential for growth and maintenance of the body. It plays an important role during embryonic development and generally absent in adults with some exceptions like during wound repair and menstrual cycle in women. Excess as well as deficiency in angiogenesis, result in pathological conditions. It is a tightly regulated process; rely on cascade of several molecular signalling pathways involving many effectors like VEGF, FGF, PDGF, IGF etc. Excessive angiogenesis is associated with disorders like tumor, atherosclerosis, rheumatoid arthritis, diabetic retinopathy, endometriosis, psoriasis, adiposity...
September 11, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28831911/nanoparticle-based-drugs-an-armament-for-effective-anti-cancer-therapy
#5
Khurshid Ahmad, Gulam Rabbani, Mohammad Hassan Baig, Jeong Ho Lim, Mohammad Ehtisham Khan, Eun Ju Lee, Ghulam Md Ashraf, Inho Choi
Cancer is known to be a foremost cause of mortality worldwide. Available treatments (radiation, hormone, chemotherapy, and immunotherapy) being non-specific and unable to cross biological barriers, have restricted their use producing in humans. With greater side effects, there is a change in trend towards exploration of nano-technological approaches to achieve site specific delivery of drugs. Nanoparticles being unique on nanometer-scale size and large surface to volume ratio, are highly efficient in the delivery of potent drugs to specific tumor sites...
August 22, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28799487/dementia-etiologies-and-remedies-in-traditional-persian-medicine-a-review-of-medicinal-plants-and-phytochemistry
#6
Laila Shirbeigi, Behnam Dalfardi, Zohre Abolhasanzade, Fatemeh Nejatbakhsh
BACKGROUND: Dementia is a chronic neurodegenerative disease causing progressive and gradual impairment of different brain's cognitive functions. The prevalence of dementia is about 3 to 7% in different parts of the world. OBJECTIVE: The aim of this study was to determine the etiologies of dementia according to the Traditional Persian Medicine scientists' viewpoint and introduce their recommended herbal remedies for this disease. METHOD: The authors explored six main Traditional Persian Medicine textbooks for the disease of dementia, its etiologies and related recommended herbal treatments...
August 10, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28758579/perspectives-of-medieval-persian-medicine-on-multiple-sclerosis
#7
Mohammad Ali Sahraian, Mohsen Parviz, Behnam Sheibani, Nicoline Schiess, Zahra Ghorbanifar, Mohammad Kamalinejad, Esmail Nazem, Omid Sadeghpour, Hossein Rezaeizadeh
INTRODUCTION: Traditional Persian Medicine (TPM) was the prevailing practice of medicine in the Eurasia region up through the 18th century, a practice of medicine stemming back to Hippocrates and to the 5000 year old civilization of the region. It is a school of medicine which touches on many a delicate points which may seem unimaginable within the realm of modern allopathic medicine. This practice of ancient medicine besides shedding light on various possible theoretical modern day disorders serves as a vast resource for therapeutics...
July 28, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28758578/advances-in-the-use-of-multifunctional-mesoporous-silica-nanoparticles-and-related-nanomaterials-as-carriers-for-the-cancer-treatment
#8
Chunyu Song, Xinghua Wang, Yujun Wang, Hongbo Yu, Yali Cui, Tengchuang Ma
In recent years, there has been an unprecedented expansion in the field of nanomedicine with the development of new nanoparticles for the diagnosis and treatment of cancer. It is also known that the use of nanocarriers as drug delivery systems for therapeutic or imaging agents can improve the pharmacological properties of ordinarily used compounds in cancer diagnosis and treatment. Advances in the surface regulating of nanoparticles to accommodate targeting ligands turned nanocarriers attractive candidates for future impact involving targeted drug delivery...
July 28, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28758577/translational-shift-of-hsp90-as-a-novel-therapeutic-target-from-cancer-to-neurodegenerative-disorders-an-emerging-trend-in-the-cure-of-alzheimer-s-and-parkinson-s-diseases
#9
Qamre Alam, Mohammad Zubair Alam, Khalid Hussain Wali Sait, Nisreen Anfinan, Abdul Wahab Noorwali, Mohd Sajjad Ahmad Khan, Mohammad A Kamal, Absarul Haque
Parkinson's disease (PD) is considered as the second most common neurodegenerative disorder after Alzheimer's disease (AD). Despite having extensive research, the apparent pathogenic mechanism of these neurodegenerative disorders has not yet been fully understood. Recently, a ubiquitous molecular chaperone known as Heat Shock Protein 90 (HSP90) has been shown to play a key role in averting protein mis-folding and involves in assisting immature protein aggregation through inhibition of apoptotic activity in neuro-inflammatory disease...
July 28, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28738769/endogenous-biomarkers-to-assess-drug-drug-interactions-by-drug-transporters-and-enzymes
#10
T Thanga Mariappan, Hong Shen, Punit Marathe
Drug-drug interactions (DDI) by modulation of drug transporters or drug metabolizing enzymes are common in multi-drug therapy. DDI potential of any new drugs are assessed by conducting separate clinical studies using relevant probe substrates, which involves additional resource and cost. Recently, several endogenous compounds were evaluated as substrates of transporters and enzymes that could be assessed as part of early clinical trials along with the assessment of drug pharmacokinetics, pharmacodynamics and safety studies...
July 24, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28738768/current-status-of-the-pharmacokinetics-and-pharmacodynamics-of-hiv-1-entry-inhibitors-and-hiv-therapy
#11
Fengyan Xu, Edward P Acosta, Liyu Liang, Yingchun He, Juan Yang, Corenna Kerstner-Wood, Qingshang Zheng, Jihan Huang, Kun Wang
Human immunodeficiency virus (HIV) entry inhibitors target the first step of the HIV life cycle and efficiently inhibit HIV from infecting the immune cells which is a key prerequisite for viral spread. Because of their unique mechanism of action on cell-cell transmission they may provide a promising perspective for the treatment of AIDS. Maraviroc (MVC) and Enfuvirtide (ENF) have been approved by the FDA for the treatment of HIV-1 infection. Attachment inhibitors (BMS-663068 and TNX-355) and co-receptor inhibitors (PRO-140 and Cenicriviroc (CVC)) have reached phase II or III clinical trials...
July 24, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28721833/role-of-nutrients-and-phyto-compounds-in-the-modulation-of-antimicrobial-resistance
#12
Steve Harakeh, Imran Khan, Saad B Almasaudi, Esam I Azhar, Soad Al-Jaouni, Aleksandra Niedzweicki
Antimicrobial resistance is quickly spreading and has become a major public health problem worldwide. If this issue is not resolved, it may cause a shift back to the pre-antibiotics era and infectious disease will again be a serious problem, especially in developing countries. Since the discovery of antibiotics, bacterial resistance has emerged, enabling certain bacteria to withstand antibiotic effects. The emergence of antibiotic resistance is fueled by excessive and improper use of antimicrobial agents, especially in developing countries...
July 18, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28699508/edible-vaccine-current-status-and-future-perspectives
#13
Sayed Sartaj Sohrab, Mohd Suhail, Mohammad A Kamal, Azamal Husen, Esam I Azhar
Growing world population and continuous disease emergence have invited the development of more efficient new vaccines against a range of diseases. Conventional vaccines are being wildly used in the world but their production requires higher cost, more time and better infrastructure. Thus, the idea of plant-based edible vaccine technology has emerged and showed promising results with strong and effective protection against many diseases. Plants have been utilized since more than two decades as pharmaceuticals against many diseases...
July 11, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28699509/combination-of-multifunctional-nanoparticles-and-interventional-techniques-makes-each-other-going-further-in-the-field-of-cancer-treatment
#14
Haibo Shao, Tengchuang Ma, Duo Hong, Wenhan Xu, Shuai Li, Ronald S Arellano, Ke Xu
Nano-oncology and interventional oncology are both rapidly emerging fields in loco-regional cancer therapies. Synergistic combination of both fields offers drastic improvement in performance and efficacy of cancer killings. Interventional techniques such selective arterial catheterization, irreversible electroporation (IRE) and radiofrequency ablation (RFA) had dramatically enhance the cancer targetability and anticancer efficacy of nanoparticles (NPs). Furthermore, there is synergistic effect by using different interventional techniques together on NPs assisted cancer treatment...
July 10, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28699507/quinolones-and-fluroquinolones-metabolism-and-resistance-in-salmonella-typhimurium-a-mini-review
#15
B Preethi, V Shanthi, K Ramanathan
Salmonella enterica serovars causes substantial morbidity and mortality worldwide. More than 2500 different serotypes of Salmonella were identified to date. In particular, Salmonella enterica serovar typhimurium is the most important serotype of Salmonella transmitted from animals to humans in most parts of the world. They are associated with an estimated 1 million deaths annually. Quinolones are an important class of broad-spectrum antimicrobials has been utilized in the treatment option for over 40 years...
July 10, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28699506/natural-or-plant-products-for-the-treatment-of-neurological-disorders-current-knowledge
#16
Mohammad Khalid Parvez
In recent decades, complementary and alternative medicine (CAM) has become very popular in the treatment of several chronic diseases. Natural products as one of the CAM modalities offer potential opportunities to discover lead compounds for novel drug development. The use of CAM or natural products in the prevention of neurodegenerative diseases is comparatively a newer area. Natural therapeutics with anti-oxidative and anti-inflammatory salutations evidently plays a crucial role in protecting neurons. Of these, the most promising are caffeine, trigonelline, shogaol, curcumin, resveratrol, baicalein, wogonin, ginsenosides, tanshinones, withanolides, picrosides, parthenolide, cannabinoids, Devil's claw and white willow bark, including Chinese formulations Renshen Shouwu and Shengmai San...
July 10, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28595534/a-review-of-levetiracetam-in-neonates
#17
Amit Agrawal, Anita Banergee
BACKGROUND: Neonatal seizures are the most common clinical manifestation of central nervous system (CNS) dysfunction and are associated with various neurological sequelae. There are currently no evidence-based guidelines for the management of neonatal seizures and currently used drugs such as phenobarbital, and phenytoin have limited efficacy and potential toxicities. Newer second line anticonvulsant, levetiracetam, has been used in refractory neonatal seizures despite limited data and off-label use...
June 6, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28595533/recent-advances-of-computational-modeling-for-predicting-drug-metabolism-a-perspective
#18
Supratik Kar, Jerzy Leszczynski
Absorption, Distribution, Metabolism, Excretion (ADME) properties along with drug induced adverse effects are the major reasons for the late stage failure of drug candidates as well as cause for the expensive withdrawal of many approved drugs from the market. Considering adverse effects of drugs, metabolism factor has great importance in medicinal chemistry and clinical pharmacology because it influences the deactivation, activation, detoxification and toxification of drugs. Computational methods are effective approaches to reduce the number of safety issues by analyzing possible links between chemical structures and metabolism followed by adverse effects, as they serve the integration of information on several levels to enhance the reliability of outcomes...
June 6, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28595532/pharmacological-and-toxicological-profile-of-harmane-%C3%AE-carboline-alkaloid-friend-or-foe
#19
Haroon Khan, Seema Patel, Mohammad A Kamal
The plant secondary metabolites have an outstanding therapeutic potential and success over the years. In fact, it is the foundation of numerous clinically used drugs. Similarly, there is a general perception that these products usually have safe option. However, such products might have toxic/unwanted lethal effects therefore, along with biological relevance, toxicological evaluation is equally important for clinical applications. Harmane-β-carboline alkaloid has shown several pharmacological activities such as antianxiety, antidepressant, antiplatelet, antidiabetic, acetylcholinesterase and myeloperoxidase inhibition, antioxidant, antiparasitic, hypotensive, morphine withdrawal syndrome alleviation, and antinociceptive effects...
June 6, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28595531/repurposed-drugs-as-potential-therapeutic-candidates-for-management-of-alzheimer-s-disease
#20
Muhammad Shoaib, Mohammad A Kamal, Syed Mohd Danish Rizvi
Drug repurposing is an innovative approach as it provides fresh implications to previously approved and established drug compounds. Due to high failure rates and cost involved in the drug development process, many pharmaceutical companies are primarily focusing on drug repurposing strategy. In Alzheimer disease, existing therapeutic agents only provide symptomatic benefits and does not get involved in disease modification, therefore, the alternative approach of repurposing could be applied to inhibit neurodegeneracy process and other pathological complications...
June 6, 2017: Current Drug Metabolism
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