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Current Drug Metabolism

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https://www.readbyqxmd.com/read/28164752/exploration-of-various-proteins-for-the-treatment-of-alzheimer-s-disease
#1
Badar Ul Islam, Syed Kashif Zaidi, Mohammad Amjad Kamal, Shams Tabrez
Alzheimer's disease (AD) is an irreversible multifaceted neurodegenerative disorder that gradually degrades neuronal cells. It is the most frequent cause of memory loss and dementia in elderly individuals worldwide. The extracellular deposition of beta amyloid (Aβ), intracellular neurofibrillary tangles (NFTs) retention, neuronal decline and neurotransmitter system derangement has been suggested as the patho-physiological marker of this devastated disease. In view of limited treatment option and success rate, there is an urgent need to explore the vast array of proteomes for the management of AD...
February 3, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28155624/past-recent-progresses-and-future-perspectives-of-nanotechnology-applied-to-antifungals-agents
#2
Luís Roque, Jesús Molpeceres, Cláudia Reis, Patrícia Rijo, Catarina Pinto Reis
Candida species remain a significant cause of nosocomial bloodstream infections, associated with prolonged hospital stay in the ICU and high healthcare cost. The incidence of Candida is very high in certain risk groups of patients (AIDS, diabetes, cancer, etc.). Recent developments of nanotechnology have strongly contributed to the design of new multifunctional drug carriers that improve drug bioavailability through a controlled and prolonged release profile or even through a more specific targeted delivery of the antifungal agent...
February 1, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28155623/pancreatic-cancer-therapy-review-from-classic-therapeutic-agents-to-modern-nanotechnologies
#3
Ana Rebelo, Jesús Molpeceres, Patrícia Rijo, Catarina Pinto Reis
Pancreatic cancer remains one of the most lethal cancers worldwide, with an extremely poor prognosis. This cancer is considered the 5th leading cause of cancer related death. The median survival after diagnosis is generally 2-8 months and five-year survival rate is less than 5%. In recent years, nanotechnology is emerging as a rising approach for drug delivery since it has opened up new landscapes in medicine through introduction of smart nanocarrier systems that can selectively deliver the therapeutic agent in a specific region and in appropriate levels, reducing the adverse side effects...
February 1, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28124594/strategies-of-engineering-nanoparticles-for-treating-neurodegenerative-disorders
#4
Khanh Tu Nguyen, Minh Nguyet Pham, Toi Van Vo, Wei Duan, Phuong Ha-Lien Tran, Tran Truong-Dinh Thao
Neurodegenerative disorders (NDs) are typically referred to Alzheimer's disease, Parkinson's diseases, amyotrophic lateral sclerosis and prion disease. These are commonly debilitating and, unfortunately, have few therapeutic options. One of the main difficulties in fighting against NDs is to overcome the shielding of blood-brain barrier (BBB), which greatly limits the penetration of various therapeutic drugs, which sometimes leads to severe side effects. Nanotechnology, by engineering materials of a size scale usually within 1-100 nm, fortunately offers an alternative approach for novel, promising and innovative solutions...
January 25, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28117000/vasopressin-and-related-peptides-potential-value-in-diagnosis-prognosis-and-treatment-of-clinical-disorders
#5
Ewa Szczepanska-Sadowska, Tymoteusz Zera, Piotr Sosnowski, Agnieszka Cudnoch-Jedrzejewska, Anna Puszko, Aleksandra Misicka
Vasopressin (AVP) and its receptors play a pivotal role in maintaining body homeostasis under physiological and pathophysiological conditions. As a consequence, the vasopressin system has emerged as an important target for both diagnostic and therapeutic applications in a number of medical conditions. Stoichiometric generation of AVP with copeptin, which is relatively accessible in the blood for measurements, makes copeptin a valuable surrogate of AVP. In this review, we present the regulation of release of AVP and activation of V1a, V1b, and V2 vasopressin receptors under physiological and pathological conditions...
January 19, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28093994/viral-infection-and-obesity-current-status-and-future-prospective
#6
Sayed Sartaj Sohrab, Mohammad Amjad Kamal, Richard L Atkinson, Maha M Alawi, Esam I Azhar
The association of pathogenic viruses with obesity has now been well-known in both human and animals. Globally, human obesity has become a serious problem leading to the emergence of multiple life-threatening diseases. Adenoviruses contribute a significant role in the induction of obesity by affecting various pathways. Due to impaired immunity, obese individuals are more prone to nosocomial infections leading to complications of obesity. In contrast, several other important factors contributing to human obesity are known...
January 16, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28093993/methods-of-screening-purification-and-antimicrobial-potentialities-of-bacteriocin-in-health-care
#7
Varish Ahmad, Qazi Mohammad Sajid Jamal, Mughees Uddin Siddiqui, Arun K Shukla, Mohammad A Alzohairy, Mohammad A Al Karaawi, Mohammad Amjad Kamal
The Antibiotics of twentieth century have emerged to decrease the mortality and morbidity among the human population, but these are costly and toxic to beneficial intestinal micro flora. The safe and convenient proteinacious antimicrobial molecule, active at nanomolar concentration and synthesized by ribosomes, is bacteriocin. It has been tested not only to inhibit a wide range of microbial pathogens, but also to treat and diagnose the cancer. Its use as bio-controlling agent in agriculture also accelerated the research of bacteriocin...
January 16, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28093992/effects-of-thyroid-hormones-and-their-metabolites-on-learning-and-memory-in-normal-and-pathological-conditions
#8
Alice Accorroni, Grazia Chiellini, Nicola Origlia
BACKGROUND: Classical thyroid hormones have an established necessary role in the normal development of the central nervous system, and they have been recently considered as decisive factors influencing cognitive functions in adult brain and involved in the development of Alzheimer's disease. The picture summarizing thyroid hormone effects on adult brain, however, does not only include classical thyroid hormones but also the products of their peripheral metabolism. These latter have been considered as inactive breakdown products for long but recently were proved to produce significant biological effects...
January 16, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28093991/cancer-nanotechnology-recent-trends-and-developments-in-strategies-for-targeting-cancer-cells-to-improve-cancer-imaging-and-treatment
#9
Jingyao Xu, Xiaoling Zhou, Yifei Li, Yudan Tian
Nanotechnology is a multidisciplinary field, which have the potential to cover applications in many subjects such as biology, chemistry and physics. The combined efforts of these subjects can lead to the successful engineering of nanodevices and nanovectors for targeted delivery and sensing/detection of cancer cells/tissues. The modulation of nanomaterials at surface and bulk level further adds value to this technology and develop strategies for early detection of precancerous and malignant cells from biological fluids...
January 16, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28093990/insight-to-pharmacokinetics-of-tkis-optimizing-practical-guidelines-for-individualized-therapy
#10
Ruiqing Wang, Chaoqin Zhong, Chen Zhang, Mingqiang Hua, Daoxin Ma
Tyrosine kinase inhibitors (TKIs) are widely used drugs which have high availability in reducing the activity of BCR-ABL1 tyrosine kinase, therefore they play an indispensable role in the treatment of Chronic myeloid leukemia (CML). Imatinib, dasatinib and nilotinib have been proved to have absolute bioavailability and stable blood concentration in humans. TKIs pharmacokinetics has close relationships with the clinical response and clinical treatment of CML. We conducted a systematic PubMed search to look for studies relating to TKIs pharmacokinetics with proper inclusion/exclusion criteria...
January 16, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28093998/potential-of-plant-alkaloids-as-antipyretic-drugs-of-future
#11
Imad Ahmad, Haroon Khan, Anwar Ul-Hassan Gilani, Mohammad A Kamal
Fever or Pyrexia means abnormal rise in body temperature above the usual range of normal in response to a variety of infectious, immunological and neoplastic stimuli. To normalize these febrile conditions, several synthetic agents are in clinical practice such as acetaminophen, ibuprofen, and aspirin. However, they are having many side effects which sometimes challenge their applications. The various sources are under investigation worldwide to overcome issues of unwanted effects and to better therapeutic response...
January 15, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28093997/sonication-assisted-nanoprecipitation-in-drug-delivery
#12
Anh Thi Ngoc Vo, Thinh Duc Luu, Minh Ngoc Uyen Nguyen, Toi Van Vo, Wei Duan, Phuong Ha-Lien Tran, Thao Truong-Dinh Tran
Sonication-assisted nanoprecipitation provides an effective tool for nanomedicine engineering in therapeutic improvement. In the scope of this review, original works in interdisciplinary areas of using sonication with precipitation method for nanoparticulate drug delivery systems and its applications in management of different diseases are discussed. The use of sonication-assisted nanoprecipitation has been proved to improve drug bioavailability, which attracts tremendous interests as an effective strategy for drug delivery...
January 15, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28093996/challenges-related-to-glycemic-control-in-type-2-diabetes-mellitus-patients
#13
Masoumeh Kheirandish, Hamidreza Mahboobi, Maryam Yazdanparast, Mohammad Amjad Kamal
Diabetes mellitus (DM) is a chronic disease with long-term complications. Glycemic control is an important part in management of DM. The first line in treatment of type 2 DM (T2DM) is diet and life style change. Metformin is the first choice of medication in T2DM patients. Sulfonylureas have high risk of hypoglycemia. Glinides are associated with lower risk of hypoglycemia in comparison to sulfonylureas. Also α-glucosidase inhibitors decrease the polysacarides digestion in small intestine and less effective in comparison to metformin and sulfonylureas in lowering hemoglobin A1c (HbA1c)...
January 15, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28093995/glycosides-as-possible-lead-antimalarial-in-new-drug-discovery-future-perspectives
#14
Marya, Haroon Khan, Izhar Ahmad
Malaria remains one of the major public health problems worldwide and is responsible for a large number of morbidity and mortality. Especially, in the third world countries, it is still alarming. The development of drug-resistant to Plasmodium falciparum strains has further degraded the overall situation. However, a limited number of effective drugs available emphasizes how essential it is to establish new anti-malarial compounds. New antimalarial agents with distinctive structures and mechanism of action from the natural origin are thus immediately required to treat sensitive and drug-resistant strains of malaria...
January 15, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28088890/nanoparticles-as-a-carrier-system-for-drug-delivery-across-blood-brain-barrier
#15
Alika Sarkar, Ismat Fatima, Qazi Mohammad Sajid Jamal, Usman Sayeed, M Kalim A Khan, Salman Akhtar, Mohammad Amjad Kamal, Alvina Farooqui, Mohammad Haris Siddiqui
Brain, the center of the nervous system and an integral part the body, is protected by two anatomical and biochemical dynamic barriers- Blood-Brain Barrier (BBB) and Blood-Cerebrospinal Fluid Barrier (BCSFB). Blood-Brain Barrier is a highly complex multi-cellular organized structure that protects the brain from harmful substances and invading organisms from the bloodstream and thus protecting it from diseases and injuries. However, it also significantly precludes the delivery of drug to the brain, thus, preventing treatment of a number of neurological disorders...
January 13, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28059039/studies-on-the-metabolism-of-nitrogen-compounds-by-prof-j-w-gorrod
#16
Mert Ulgen, Neval Sevinc
The scientific research papers by Professor John William Gorrod who died in December 2015 are reviewed. He was one of the most important scientists in the area and investigated mainly the biological oxidation of nitrogen containing drugs and xenobiotics. In this review, more than 200 papers belong to him are evaluated, most of which involved the results from in vitro microsomal oxidative metabolism of nitrogen containing xenobiotics. These studies include the carcinogenicity of tobacco smoke constituents, aromatic amines, aminophenols, rubber and aminobiphenyls, the assay for ferriheamoglobinemia forming compounds, metabolism of aralkyl azo compounds, aromatic amines, aromatic azaheterocycles, synthesis of N-oxidative metabolites i...
January 5, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28059038/toxicities-of-receptor-tyrosine-kinase-inhibitors-in-cancer-pharmacotherapy-management-with-clinical-pharmacology
#17
Ken-Ichi Fujita, Hiroo Ishida, Yutaro Kubota, Yasutsuna Sasaki
A number of molecularly targeted anticancer drugs that efficiently inhibit receptor tyrosine kinases, so-called receptor tyrosine kinase inhibitors (TKIs), have been developed. Although these receptor TKIs are generally well tolerated, unexpected toxicities sometimes occur in various organs. TKI-induced adverse events not only lower the quality of life of cancer patients but also reduce dose intensity, and sometimes result in treatment discontinuation. To reduce adverse drug events and increase treatment efficacy, oncologists and clinical pharmacologists have made efforts to establish strategies to treat patients via optimal selection and dosing of TKIs...
January 5, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28059037/status-epilepticus-an-overview
#18
Venkata Ramesh Yasam, V Senthil, Satya Lavanya Jakki, N Jawahar
Status epilepticus (SE) is an emergency situation, where immediate and effective treatment is required in least possible time as it is associated with neuronal damage, systemic complications, substantial morbidity and mortality depending on status type, duration, age and etiology. In the past few years, morbidity and mortality rate were improved, probably may be due to aggressive use of anti-epileptic drugs in emergency situations. Present literature gives an overview of the conditions leading to SE and its management guidelines in hospital and out of hospital setting emphasizing on the available drug therapies...
January 5, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28059036/reduction-of-doxorubicin-induced-cardiotoxicity-using-nanocarriers-a-review
#19
Michaela Fojtu, Jaromir Gumulec, Tibor Stracina, Martina Raudenska, Anna Skotakova, Marketa Vaculovicova, Vojtech Adam, Petr Babula, Marie Novakova, Michal Masarik
BACKGROUND: Anthracycline antibiotic doxorubicin (DOX) is a very potent and extensively prescribed chemotherapeutic drug. It is widely utilized in the therapy of variety of haematological and solid tumours, although its administration is commonly accompanied with several severe side effects. The most serious one is a development of dose-dependent and cumulative cardiotoxicity. In the course of time, many strategies have been investigated in order to avoid or at least to diminish DOX-induced cardiac dysfunction; these include reduction of toxic effect by co-administration with iron chelators (dexrazoxane), trastuzumab, taxanes, statins, and ACE-inhibitors...
January 5, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28017133/editorial-frontier-view-on-drug-discoveries-for-different-diseases
#20
EDITORIAL
Mohammad Amjad Kamal
No abstract text is available yet for this article.
December 22, 2016: Current Drug Metabolism
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