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Current Drug Metabolism

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https://www.readbyqxmd.com/read/29788885/application-of-traditional-chinese-herbal-medicine-by-products-as-dietary-feed-supplements-and-antibiotic-replacements-in-animal-production
#1
Abedin Abdallah, Pei Zhang, Qingzhen Zhong, Zewei Sun
Misuse of synthetic antibiotics in livestock leads to the transfer of antibiotic resistant pathogens into humans and deposits toxic residues in meat and milk. There is therefore an urgent need for safe and viable alternative approaches to improve the nutrition and wellbeing of farm animals. An alternative source that has been widely exploited is traditional Chinese herbal medicine (TCHM). These herbal medicines are an important part of the healthcare system in many Asian countries. Such herbs contain several but less toxic bioactive compounds which are generally regarded biodegradable...
May 22, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29788884/progress-of-oral-insulin-and-related-drug-delivery-systems-and-their-pharmacokinetics
#2
Jingjing Chen, Rui Liu, Changxiao Liu, Xin Jin, Qinghua Zhang, Jialu Wang, Fang Zhao, Ze Wang, Haiyan Qiu, Yazhuo Li, Xiulin Yi
BACKGROUND: As society has developed and living standards have improved, diabetes has become a severe public health issue. Insulin plays a crucial role in managing hyperglycemia caused by type I diabetes and particular type II diabetes. Many researchers are seeking alternative, more acceptable methods of insulin delivery, such as oral insulin. An oral formulation has become a new goal for insulin delivery in recent years. METHODS: The PubMed and CNKI databases were searched for "oral insulin, " "drug delivery systems, " and "pharmacokinetics, " and 85 relevant articles were selected from the results as material for this review...
May 22, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29788883/models-of-drug-induced-liver-injury-dili-current-issues-and-future-perspectives
#3
Lucija Kuna, Ivana Bozic, Tomislav Kizivat, Kristina Bojanic, Margareta Mrso, Edgar Kralj, Robert Smolic, George Y Wu, Martina Smolic
Drug-induced liver injury (DILI) is an important cause of acute liver failure cases in the United States, and remains a common cause of withdrawal of drugs in both preclinical and clinical phases. In this article, we review the existing knowledge of appropriate models to study DILI in vitro and in vivo with special focus on hepatic cell models, variations of 3D co-cultures, animal models, databases and predictive modeling and translational biomarkers developed to understand the mechanisms and pathophysiology of DILI...
May 22, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29788882/impact-of-drug-metabolism-pharmacokinetics-and-their-relevance-upon-taxus-based-drug-development
#4
Da-Cheng Hao, Guang-Bo Ge, Ping Wang, Ling Yang
Drug metabolism and pharmacokinetic (DMPK) studies of Taxus natural products, their semi-synthetic derivatives and analogs are indispensable in the optimization of lead compounds and clinical therapy. These studies can lead to development of new drug entities with improved absorption, distribution, metabolism, excretion and toxicity (ADME/T) profiles. To date, there have been no comprehensive reviews of the DMPK features of Taxus derived medicinal compounds.Natural and semi-synthetic taxanes may cause and could be affected by drug-drug interaction (DDI)...
May 22, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29749309/the-application-of-natural-products-in-cancer-therapy-by-targeting-apoptosis-pathways
#5
Yan Wang, Jian Zhong, Jiaojiao Bai, Rongsheng Tonga, Feifei An, Pengcheng Jiao, Lin He, Daiwen Zeng, Enwu Long, Junfeng Yan, Jiying Yu, Lulu Cai
Apoptosis is one of the pathways of programmed cell death (PCD), which leads to pathognomic cellular changes different from cellular necrosis. It includes the death receptor pathway and the mitochondrial pathway, both of which involve many key proteins, including cytochrome c, Fas, the Bcl-2 family, caspases, survivin and p53. In apoptosis-related diseases, such as cancer, many proteins associated with apoptosis are abnormally expressed. The majority of anti-cancer agents promote apoptosis to induce cancer cell death...
May 11, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29749308/polysaccharide-nanoparticles-for-targeted-cancer-therapies
#6
Peipei Peng, Ke Yang, Gangsheng Tong, Liang Ma
Nanomedicines are novel drug delivery systems which can be devised to optimize the biodistribution, pharmacokinetics and pharmacodynamics of single or multiple drugs to improve the therapeutic index, reduce the systemic toxicity and increase the antitumor efficacy. Numerous classes of materials have been applied to construct nanomedicines, while the potential safety concern raised from the synthetic components during construction significantly impedes the clinical translation of nanomedicines. In virtue of their unique hydrophilicity, biocompatibility, biodegradability and modifiability, natural biopolymers have been widely employed as either coating materials or backbones to realize targeted cancer therapy with desirable biosafety...
May 11, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29749307/advances-in-long-circulating-drug-delivery-strategy
#7
Xinyu Zhang, Shaohan Zhang, Yang Kang, Keqing Huang, Zhipeng Gu, Jun Wu
For safe and effective therapy, drugs are supposed to be actively targeted at the desired disease locations. As a promising candidate for drug delivery, long circulating system with various strategies has been widely used. Recently, biomimetic strategies mediated long circulation of drug delivery system have been increasingly developed for forming various nanoparticles and shown the anticipated potential. In this review, a variety of approaches for long circulation strategy have been surveyed, together with different modifications...
May 11, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29708074/the-relationship-between-lithium-and-cancer-proliferation-a-case-based-review-of-the-literature
#8
Aysegul Ozerdem, Deniz Ceylan, Bilge Targıtay
BACKGROUND: The incidence and mortality rates of cancer in patients with bipolar disorder (BD) is higher compared with the gen-eral population. The role of lithium (Li) in cancer proliferation/inhibition is still a controversial issue in the literature. OBJECTIVE: Based on a clinical case with lithium intake and development of a renal tumor, we aimed to explore the relationship between Li use and tumor proliferation, with regard to the mechanism of action of Li...
April 29, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29708073/soy-isoflavones-and-their-effects-on-xenobiotic-metabolism
#9
Tianjiao Zhou, Chengzhen Meng, Pingli He
BACKGROUND: Soy isoflavones, such as genistein and daidzein, are bioflavonoids found in soy products that are able to interact with various hormones such as estrogen. Epidemiological studies reveal a proper level of isoflavones in diet can prevent many diseases like cancers or diabetes. Therefore, it is important to study the biotransformation and xenobiotic metabolism of soy isoflavones. METHODS: A systematic review of published studies was carried out to investigate the characterization of isoflavones and their metabolites, sample pretreatment and quantitative analysis of isoflavones, and the influence of soy isoflavones on drug and xenobiotic metabolism...
April 27, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29708072/a-review-on-clinical-pharmacokinetics-pharmacodynamics-and-pharmacogenomics-of-natalizumab-a-humanized-anti-%C3%AE-4-integrin-monoclonal-antibody
#10
Li Hao, Shi Fang-Hong, Huang Shi-Ying, Zhang Shun-Guo, Chen Min-Ling
Natalizumab (Tysabri®, Biogen-Idec Inc., NAT), a humanized anti-α4 integrin monoclonal antibody, binds in both α4β1 (Very Late Antigen 4, VLA-4) and α4β7 (lymphocytes Peyer's patch adhesion molecule 1, LPAM-1) integrins, is approved for the treatment of Multiple sclerosis (MS) and Crohn's disease (CD). NAT has been well tolerated in pivotal trials. Progressive multifocal leukoencephalopathy (PML) is an uncommon but serious complications resulting from NAT treatment. It is not confirmed that higher NAT concentration increases the risk of PML...
April 27, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29708071/research-progress-of-progesterone-preparations-a-mini-review
#11
Mingzhu Ye, Weisan Pan, Xinggang Yang, Xiaoyu Zhang
BACKGROUND: Progesterone is a sex steroid hormone. Since it was discovered, it had been widely used in the prevention of spontaneous preterm birth, hormone replacement therapy and other gynecological conditions. METHOD: We will review the progesterone preparations based on a comprehensive study of papers and patents from the traditionally preparations up through the very recent literatures. RESULTS: This review mainly concentrates on oral, vaginal and micro delivery systems, involving different ways to prepare progesterone preparations...
April 27, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29708070/drug-induced-cholestasis-mechanisms-models-and-markers
#12
Sagnik Chatterjee, Pieter Annaert
Drug-induced cholestasis is a risk factor in progression of drug candidates, and poses serious health hazard if not detected before going into human. Intrahepatic accumulation of bile acids (BAs) represents a characteristic phenomenon associated with drug-induced cholestasis. The major challenges in obtaining a complete understanding of drug-induced cholestasis lies in the complexity of BA-mediated toxicity mechanisms and the impact of bile acids at different 'targets' such as transporters, enzymes and nuclear receptors...
April 27, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29708069/indoles-gut-bacteria-metabolites-of-tryptophan-with-pharmacotherapeutic-potential
#13
Piotr Konopelski, Marcin Ufnal
Increasing evidence proves the pivotal role of gut microbiota in mammals' homeostasis. Gut bacterial metabolites may exert local effects on the intestines, and may enter the circulation, affecting the functions of virtually all organs. Indoles represent a wide group of gut bacteria-derived compounds produced from tryptophan, an essential amino acid and the precursor of endogenous synthesis of tryptamine, serotonin and melatonin. Recently, it has been suggested that gut microbiota and their metabolites, including indoles, may be involved in the etiology of cardiovascular, metabolic, and psychiatric diseases...
April 27, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29663879/anti-cancer-effects-of-metformin-recent-evidences-for-its-role-in-prevention-and-treatment-of-cancer
#14
Masoumeh Kheirandish, Hamidreza Mahboobi, Maryam Yazdanparast, Warda Kamal, Mohammad A Kamal
Metformin is widely used for the management of type 2 diabetes mellitus (T2DM). Recently growing evidence has shown its anti-cancer effects. The results are mainly obtained from observational studies and thus, little information is available concerning the mechanisms of action. Adenosine monophosphate (AMP)-activated protein kinase (AMPK) plays an important role in the mechanism of action of metformin. The anti-cancer mechanisms of metformin include direct and indirect effects. The direct effects of metformin include AMPK-independent and AMPK-dependent effects, whereas the decrease in glucose level, hyperinsulinemia, and Insulin-like growth factor 1 (IGF-1) level was considered its indirect effects...
April 16, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29663878/role-of-angiogenenic-growth-factors-in-psoriasis-a-review
#15
Tahseena Akhtar, Willayat Yousuf Wani, Mohammad A Kamal, Rajinder Kaur
BACKGROUND: Psoriasis is a chronic inflammatory disease, involving autoimmune mechanism wherein immune system, autoantigens and various environmental triggers all interact to create the systemically diseased state. It is a multifactorial skin disease of complex nature characterized by infiltration of multiple immune cells, kerationcyte proliferation, and increased dermal vascularity. Among all factors, vascular alterations present a significant feature of the disease and angiogenesis seems to have an important role in giving rise to psoriasis phenotype...
April 16, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29623833/new-therapeutic-drugs-from-bioactive-natural-molecules-the-role-of-gut-microbiota-metabolism-in-neurodegenerative-diseases
#16
Francesco Di Meo, Stella Donato, Alba Di Pardo, Vittorio Maglione, Stefania Filosa, Stefania Crispi
The gut-brain axis is considered a neuroendocrine system, which connects brain and gastrointestinal tract and plays an important role in stress response. The homeostasis of gut-brain axis is important for healthy conditions and its alterations are associated to neurological disorders and neurodegenerative diseases. Gut microbiota is a dynamic ecosystem that can be altered by external factors such as diet composition, antibiotics or xenobiotics. Recent advances in gut microbiota analyses indicate that the gut bacterial community plays a key role in maintaining normal brain functions...
April 3, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29623832/herbs-with-potential-nephrotoxic-effects-according-to-traditional-persian-medicine-review-and-assessment-of-scientific-evidence
#17
Fatemeh Kolangi, Zahra Memariani, Mahboubeh Bozorgi, Seyyed Ali Mozaffarpur, Mohaddeseh Mirzapour
BACKGROUND: The increased use of herbal remedies particularly in patients with kidney diseases indicated the importance of studies which focused on nephrotoxic plants. OBJECTIVE: The present study aimed to review and assess the kidney-damaging herbs mentioned in the Persian medicine [PM] books. METHODS: The main PM books were searched for nephrotoxic herbs and their relevant reformers traditionally proposed for preventing renal damage. PubMed, Scopus and Google Scholar were investigated for evaluation of the scientific evidence relating to the nephrotoxicity of herbs...
April 3, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29623831/proteomics-approach-for-biomarker-research-in-major-depression-antidepressant-effects
#18
Tiao-Lai Huang, Li-Hua Lo
The proteomics approach is the new mantra in disease biomarker research in areas such as major depression (MD). Current protocols for investigating biomarkers in biological fluid often employ both immuno-based and non-immuno-based technologies. The immuno-based method is used normally in measuring well-known disease biomarkers, and commercial kits are often available. Immuno-based methods such as radio-immunoassay and enzyme-linked immunosorbent assay are sensitive and specific. However, tedious sample preparations such as filtration and centrifugation are required...
April 3, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29600757/preclinical-hepatoprotective-effect-of-herbalism-against-ethanol-induced-hepatotoxicity-a-review
#19
Hina Firdous, Talib Hussain, Monika Singh, Syed Mohd Danish Rizvi, Afrasim Moin, Mohammad A Kamal
Liver ailments including alcoholic liver disease (ALD), still remain the main reason for morbidity & mortality worldwide. In fact, ALD is a multifactorial disease with complex pathophysiology which is linked to several types of liver damages including steatohepatitis, fibrosis and cirrhosis. This review emphasizes on 30 herbal medicinal plants with their extracts studied for protective effect against ALD and current scientific evidence of ALD cure by thirty Indian Materia Medica including Tilia Platyphyllos, Amomum subulatum, Carica papaya, Pogostemon patchouli, Commelina benghalensis, Bacopamonnieri, Pecan nut, Allium cepa, Beta Vulgaris, Adina cordifolia, Ocimum gratissimum, Vernonia amygdalina, Sida veronicaefolia, Chenopodium album, Korean red ginseng, Elephantopus scaber, Tecomella undulata, Prunus armeniaca, Sea tangle (Laminaria japonica), Emblica officinalis, Saccharum officinarum, Cocculus hirsutus, Cassia roxburghii, Zhi-Zi-Da-Huang, Phyllanthus amarus, Aegle marmelos, Agrimonia eupatoria, Flaveria trinervia, Curcuma longa and Garcinia indica...
March 30, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29600756/potential-pharmacokinetic-herb-drug-interactions-have-we-overlooked-the-importance-of-human-carboxylesterases-1-and-2
#20
Jing Xu, Jin-Chun Qiu, Xing Ji, Hong-Li Guo, Xuan Wang, Bo Zhang, Tengfei Wang, Feng Chen
Herbal products have grown steadily across the globe over the past 10 years and have increasingly been incorporated into western medicine for healthcare aims, thereby causing potential pharmacokinetic herb-drug interactions (HDI) through the inhibition or induction of drug-metabolizing enzymes and transporters. Human carboxylesterases 1 (CES1) and 2 (CES2) are versatile enzymes involvement in the metabolism of endogenous and exogenous compounds including many important therapeutic medications. Moreover, the growing number of CES substrate drugs also underscores the importance of CES1 and CES2...
March 30, 2018: Current Drug Metabolism
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