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Current Pharmaceutical Biotechnology

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https://www.readbyqxmd.com/read/28699481/editorial-circulating-biomarkers-in-cardiovascular-diseases-a-field-of-theoretical-research-or-realistic-clinical-application
#1
EDITORIAL
Michael Behnes, Ibrahim Akin
No abstract text is available yet for this article.
July 10, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28699480/adulteration-practices-of-psychoactive-illicit-drugs-an-updated-review
#2
Renata Solimini, Maria Concetta Rotolo, Manuela Pellegrini, Adele Minutillo, Roberta Pacifici, Francesco Paolo Busardò, Simona Zaami
BACKGROUND: It is well known that powdery drugs such as cocaine and heroin are frequently adulterated or diluted predominantly to obtain more doses and to increase the drug dealer's profits, but also to enhance, to modify or to oppose drug effects. METHODS: The aim of this report is to provide an overview of the recent scientific literature on medicines as well as on new psychoactive substances, used as cutting agents (i.e. pharmacologically active adulterants) and on the related adverse health effects on consumers, possibly due to the synergistic effect of the adulterants laced with substances of abuse, which represent a matter of great concern because of the frequent fatalities...
July 10, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28685688/anti-oxidative-and-anti-microbial-activities-of-purified-mpn-1-1-from-persicaria-nepalensis-meisn-miyabe
#3
Woong-Suk Yang, Seung-Hoon Yang, Jae-Yong Lee, Seong-Ho Jang, Cheorl-Ho Kim, Cher-Won Hwnag
BACKGROUND: Persicaria is a genus of flowering plants generally used for traditional medicine and nutritional supplements in tropical and subtropical East Asian countries. Previous studies have shown that Persicaria extracts alleviate lipid peroxidation, hypertension, and inflammation. OBJECTIVE: We investigated the anti-oxidative and anti-microbial effects of ethanol extracts of Persicaria nepalensis (Meisn.) Miyabe, and isolated and identified an active compound, MPN-1-1 from the ethanol extracts...
July 5, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28669333/biomarkers-in-stable-coronary-artery-disease
#4
Jonas Rusnak, Christian Fastner, Michael Behnes, Kambis Mashayekhi, Martin Borggrefe, Ibrahim Akin
BACKGROUND: Coronary artery disease (CAD) is the most common reason for death in the western hemisphere. Therefore, a well-functioning risk-management has been established over the past decades with uprising interest in 'novel' biomarkers to predict adverse coronary events and detect patients with subclinical CAD. This review will focus on selected biomarkers belonging to the family of inflammatory markers (fibrinogen or hs-CRP) or to the family of lipid-associated markers (Lipoprotein associated PA2 or Lipoprotein a) and others are direct organ-specific biomarkers (hs-troponin, Cystatin C or NT-proBNP)...
June 30, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28669332/biomarkers-in-cardiomyopathies-and-prediction-of-sudden-cardiac-death
#5
Mathieu Kruska, Ibrahim El-Battrawy, Martin Borggrefe
BACKGROUND: Cardiomyopathies are a major cause of heart diseases in all age groups leading to heart failure and arrhythmias. Additionally, they are an important cause of sudden cardiac death (SCD) in young people. Major advances have been made in the understanding of the complex and manifold underlying pathomechanisms and their correlating blood measured biomarkers. The aim of this review is to outline the role of blood measured biomarkers in non-ischemic cardiomyopathies and their role in the prediction of sudden cardiac death...
June 23, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28641514/clinically-relevant-biomarkers-in-acute-heart-failure-an-update
#6
Agnibh Mukherji, Uzair Ansari, Martin Borggrefe, Ibrahim Akin, Michael Behnes
Acute heart failure (AHF) has been one of the fields, where owing to difficulties in diagnosis, prognostic stratification and management the associated morbidity and mortality remains unusually high. The advent of novel biomarkers apart from the traditional B-type natriuretic peptide and N-terminal proBNP involved in myocardial injury, neuro-hormonal activation, and ventricular remodeling augurs immense hope in redefining our approach towards AHF. METHODS: Biomarkers like midregional proatrial natriuretic peptide, soluble ST2, highly-sensitive troponin, and midregional proadrenomedullin are some such examples that have passed various stages of substantiation while there is an array of potential biomarkers in nascent stages like osteopontin, CTGF, GDF-15 and TGF beta-1 awaiting further reiteration...
June 22, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28641568/an-expanding-role-of-biomarkers-in-pulmonary-arterial-hypertension
#7
Mustafa Yildiz, Alparslan Sahin, Michael Behnes, İbrahim Akin
BACKGROUND: Pulmonary arterial hypertension (PAH), is a chronic disease which may cause or result from mulitple cardiopulmonary disorders. The disease has complex pathophysiological mechanisms and involves many systematic, cellular and molecular changes. Therefore, it is crutial to find out underlying mechanisms and detect biomarkers to achieve early and proper diagnosis, evaluate of disease severity, for follow-up and monitor response to treatment. Many biomarker for PAH have been investigated but yet no such biomarker has been found specific and easily accessible to use for the patients...
June 14, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28641567/biomarkers-in-acute-aortic-syndromes
#8
Mustafa Yildiz, Dogac Oksen, Michael Behnes, Ibrahim Akin
BACKGROUND: Acute aortic syndromes, being mostly underdiagnosed due to unspecific symptoms, are associated with high morbidity and mortality. Diagnosis carried out by transesophageal echocardiography, computed tomography and magnetic resonance imaging. However, there are lots of biochemical assays being investigated, but none of them used reliably to identify acute aortic syndromes. Biomarkers could accelerate the diagnostic time with cost effective way and could get place in definitive diagnostic algorithm of acute aortic syndrome...
June 14, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28641566/is-it-possible-to-treat-osteosarcoma-using-oligonucleotides-confined-into-controlled-release-drug-delivery-systems
#9
Savas Topuk, Yener Akyuva, Numan Karaaslan, Cagri Ata Mutlu, Ibrahim Yilmaz, Mehmet Isyar, Duygu Yasar Sirin, Semih Akkaya, Hanefi Özbek, Mahir Mahirogullari
PURPOSE: The present study aimed to analyze the researches that are at the experimental phase concerning osteosarcoma treatment. The researches included drug delivery systems which allow controlled release and imbue small interfering-/micro- ribonucleic acid. METHODS: Without any language preference, we searched US National Library of Medicine National Institutes of Health, Embase, OVID, Cochrane Library database of clinical trials from 1843 to May 25, 2016 and traced all the references of incorporated documents...
June 14, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28571562/advantages-and-limitations-of-current-biomarker-research-from-experimental-research-to-clinical-application
#10
Seung-Hyun Kim, Christel Weiß, Ursula Hoffmann, Martin Borggrefe
BACKGROUND: Biomarkers are indispensable tools for screening, diagnosis, and prognosis in cardiovascular diseases and their clinical application increases steadily. As cardiovascular diseases include various pathophysiological processes, no single biomarker, even natriuretic peptides, can be regarded as ideal fulfilling all necessary criteria for a comprehensive diagnostic or prognostic assessment revealing optimal clinical application. Hence, the multi-marker approaches using different biomarkers reflecting different pathophysiologies were highlighted recently...
May 31, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28571561/high-sensitivity-troponin-i-and-t-reflect-the-presence-of-obstructive-and-multi-vessel-coronary-artery-disease-being-assessed-by-coronary-computed-tomography-angiography
#11
Nadine Reckord, Michèle Natale, Agnibh Mukherji, Jonas Rusnak, Uzair Ansari, Thomas Henzler, Ursula Hoffmann, Martin Borggrefe, Kambis Mashayekhi, Thomas Bertsch, Ibrahim Akin
BACKGROUND: This study evaluates the association between high sensitivity troponin I (hsTnI) and T (hsTnT) in patients with suspected coronary artery disease (CAD) undergoing coronary computed tomography angiography (CCTA). METHODS: Patients undergoing CCTA during routine clinical care were prospectively enrolled. CCTA was indicated by a low to intermediate pre-test probability for CAD during routine clinical care. Within 24 hours before or after CCTA, blood samples were taken to measure cardiac biomarkers hsTnI, hsTnT and NT-proNBP...
May 31, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28571560/the-use-of-biomarkers-in-sepsis-a-systematic-review
#12
Konstantinos Giannakopoulos, Ursula Hoffmann, Uzair Ansari, Thomas Bertsch, Martin Borggrefe, Ibrahim Akin, Michael Behnes
BACKGROUND: Despite the extended laboratory and clinical study of sepsis, its diagnosis remains a clinical challenge. The initiation of sepsis activates many different biochemical and immunological pathways, which is expressed with alterations of many molecules on human tissues. The detection and the measurement of the concentration of such molecules, known as biomarkers, may be a diagnostic tool of great significance when the clinicians approach patients with suspected sepsis. Additionally, the may predicted the outcome and therefore they may have a role on the monitoring of the response to therapy...
May 31, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28545359/microbial-enzymatic-degradation-of-biodegradable-plastics
#13
Roohi, Kulsoom Bano, Mohammed Kuddus, Mohd Rehan Zaheer, Qamar Zia, Mohd Farhan Khan, Ghulam Md Ashraf, Gjumrakch Aliev
Background The use of different types of plastics in the world either synthetic or biodegradable has become a part in all sectors of the economy. Infrastructure such as agriculture, building and construction, telecommunication, consumer goods, packaging, health and medical are all high growth areas that ensure a spiralling demand for plastics. Lack of degradability, environmental pollution and closing of landfill sites has led to concern more about plastic waste disposal. Appropriate biodegradation should occur for these water-immiscible polymers since they eventually enter streams which can neither be recycled nor incinerated and also not despoiled with existing physical and chemical means of degradation...
May 23, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28545358/molecular-imaging-of-tumor-angiogenesis-and-therapeutic-effects-with-dual-bioluminescence
#14
Ran Wang, Kaiyue Zhang, Hongyan Tao, Wei Du, Di Wang, Ziwei Huang, Manqian Zhou, Yang Xu, Yuebing Wang, Na Liu, Hui Wang, Zongjin Li
BACKGROUND: Angiogenesis is critical for the growth of tumor by supplying nutrients and oxygen that exacerbates the metastasis and progression of cancer. Noninvasive imaging of angiogenesis during the tumor therapeutic processes may provide novel opportunities for image-guided tumor management. OBJECTIVE: Here, we want to develop a mouse animal model for assessing cancer progression and angiogenesis in the same individuals by molecular imaging. METHODS: Breast cancer model was developed with mouse breast cancer cell line 4T1 carrying a reporter system encoding a triple fusion (TF) reporter gene consisting of renilla luciferase (Rluc), red fluorescent protein (RFP) and herpes simplex virus truncated thymidine kinase (HSV-ttk) in transgenic mice, which expressed firefly luciferase (Fluc) under the promoter of vascular endothelial growth factor receptor 2 (Vegfr2-luc)...
May 23, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28524000/the-effect-of-a-common-antibiotics-doxycycline-on-non-healing-chronic-wound
#15
Dixon H Xu, Ziwen Zhu, Yujiang Fang
Up to 25% of diabetic patients will develop a diabetic foot ulcer. Chronic wounds such as diabetic foot ulcers often fail to heal with conventional therapies. In recent years, it has been identified that chronic wounds are usually associated with elevated level of matrix metalloproteinases (MMPs). Doxycycline, a cheap tetracycline antibiotic, has been shown to inhibit MMPs both in vitro and in vivo independent of its antimicrobial property. In this review, we provide an overview of the roles of MMPs in the pathogenesis of chronic wounds and explore the potential application of doxycycline as a treatment option in managing chronic wounds such as diabetic foot ulcers...
May 18, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28482785/microemulsions-for-protein-delivery-loading-optimization-and-stability
#16
Diego R Perinelli, Marco Cespi, Stefania Pucciarelli, Silvia Vincenzetti, Luca Casettari, Jenny K W Lam, Serena Logrippo, Elisa Canala, Mahmoud E Soliman, Giulia Bonacucina, Giovanni F Palmieri
BACKGROUND: Microemulsions are attractive delivery systems for therapeutic proteins and peptides due to their ability to enhance bioavailability. Although different proteins and peptides have been successfully delivered through such ternary systems, no information can be found about protein loading and the formulation stability when such microemulsions are prepared with pharmaceutically-approved oils and surfactants. The aim of this work was to optimise a ternary system consisting of water/ethyl oleate/Span 80-Tween 80 and to determine its protein loading capacity and stability, using bovine serum albumin (BSA) as a model of biomolecule...
May 7, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28464772/encapsulation-in-cell-therapy-methodologies-materials-and-clinical-applications
#17
P Gálvez-Martín, M J Martin, M A Ruiz, B Clares
The clinical application of cells and the development of new delivery systems have allowed significant advances in the field of cell therapy and encapsulation in recent years. The ability to combine cells and biocompatible matrices in the encapsulation of cells providing long-term delivery has provided new therapeutic alternatives in the development of new therapies. Cell encapsulation provides increased retention time in the target tissue improving its therapeutic efficacy. This technology involves the development of a physical barrier (natural or synthetic matrix surrounded by a semipermeable membrane) to isolate and protect cells from the host's immune system maintaining the microenvironment of embedded cells, their viability and their capacity of differentiation, improving their function in vivo, and reducing side effects associated with the use of immunosuppressive therapy...
May 1, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28464771/evaluation-of-fourteen-aurone-derivatives-as-potential-anti-cancer-agents
#18
Gheda Alsaif, Nadin Almosnid, Ian Hawkins, Zachary Taylor, Deborah L T Knott, Scott Handy, Elliot Altman, Ying Gao
BACKGROUND: Aurones are a sub-set of the flavone family that possess a number of biological activities, including anti-cancer, anti-inflammatory, anti-microbial, anti-parasitic and anti-viral. Due to their high availability, simple synthesis, and generally low toxicity, aurones could be attractive candidates for safer cancer drugs. This study aims to evaluate the anti-proliferation and anti-metastasis activity of a series of synthesized aurone derivatives. METHODS: A series of aurone derivatives with simple unsubstituted coumaranone (benzofuranone) fragments and a range of alkylidene fragments have been prepared and tested for anti-proliferation activity against human cancer cell lines A549 (lung), BT20 (breast) and MCF7 (breast), and anti-metastasis activity against A549...
May 1, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28443510/a-combination-of-egg-yolk-igy-and-phosvitin-inhibits-the-growth-of-enterotoxigenic-escherichia-coli-k88-and-k99
#19
Naiyana Gujral, Heejoo Yoo, Fatemeh Bamdad, Kwang Yong Lee, Joo-Won Suh, Hoon Sunwoo
BACKGROUND: Enterotoxigenic Escherichia coli (ETEC) is the main cause of fatal diarrhea in piglets during the first week of life and over the time of weaning. Pathogenesis of ETEC-causing diarrhea involves intestinal colonization mediated by fimbriae. Although, both IgY and egg yolk phosvitin (PV) possess antimicrobial activity, their combined activity has not been explored. A combination of IgY specific for ETEC and metal-chelating PV may show synergistic effect in reducing the growth of ETEC by inhibiting bacterial proliferation and stipulating protection against ETEC infection...
April 25, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28443509/pharmacokinetics-tissue-distribution-and-excretion-study-of-fluorescein-labeled-ps916-in-rats
#20
Yu Mingming, Wang Yuanhong, Ma Fugang, Yu Weijie, Jiang Tingfu, L V Zhihua
BACKGROUND: PS916, chitosan derivatives with shown activities in atherosclerotic and fatty liver, is being investigated as an anti-atherosclerotic agent in clinical trials in China. METHODS: Fluorescein-labeled PS916 (PS916-FTC) was prepared by the reaction with fluorescein isothiocyanate. The pharmacokinetics and bio-disposition of PS916-FTC were studied in rats after oral or intravenous administration. RESULTS: Analysis of the plasma, urine, fecal and tissue samples collected at intervals up to 72 h revealed that PS916-FTC exhibited moderate volume of distribution (Vss, 0...
April 25, 2017: Current Pharmaceutical Biotechnology
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