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Current Pharmaceutical Biotechnology

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https://www.readbyqxmd.com/read/28056729/editorial-molecular-cellular-and-pharmaceutical-as-dentistry-and-oral-and-maxillofacial-surgery-translational-research-and-transdisciplinarity
#1
David M Dohan Ehrenfest, Lidia M Wisniewska, Agata Cieslik-Bielecka, Hom-Lay Wang, Manuel Fernándes-Cruz
No abstract text is available yet for this article.
January 4, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28056728/antimicrobial-effectiveness-of-synthesized-bioactive-silver-nanoparticles-by-the-actinomycetes-hgg16n-strain
#2
Bogusław Buszewskia, Viorica Railean-Plugarua, Paweł Pomastowski, Katarzyna Rafińskaa, Malgorzata Szultka-Mlynskaa, Tomasz Kowalkowskia
BACKGROUND: Biologically synthetized silver nanoparticles are promising antimicrobial agent. Flow cytometry, well diffusion methods, colony-forming units (CFU) and spectroscopic approach are commonly used in antimicrobial study. The aims of this study were to provides information about effectiveness of BioAgNPs synthesized by Actinomycetes HGG16n using fluorescence flow cytometry method as an alternative to the standard ones (well and disc diffusion method). METHODS: It was applied flow cytometry technique to monitor the antibacterial effect of biocolloidal silver and its combination with various commercial antibiotics against selected pathogens...
January 4, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28044932/ubiquitous-pharmacogenomics-u-pgx-the-time-for-implementation-is-now-an-horizon2020-program-to-drive-pharmacogenomics-into-clinical-practice
#3
Erika Cecchin, Rossana Roncato, Hendrik Jan Guchelaar, Giuseppe Toffoli, and for the Ubiquitous Pharmacogenomics Consortium
Although the clinical validity of a number of pharmacogenetic markers is nowadays a matter of fact, and led authoritative scientific consortia as the Dutch Pharmacogenetic Working Group (DPWG) and the Clinical Pharmacogenomics Implementation Consortium (CPIC) to publish pharmacogenetic guidelines, the clinical implementation in the real life remains challenging. Ubiquitous Pharmacogenomics (U-PGx) program is a coordinated effort that put together scientific and clinical expertise in the pharmacogenomic field, to implement the pre-emptive pharmacogenomic approach in the clinical practice in Europe, and to demonstrate its benefit in both patients clinical outcome and quality of life, with an economic advantage for the healthcare system...
2, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28034294/probiotic-properties-of-lactobacillus-fermentum-strains-isolated-from-human-oral-samples-and-description-of-their-antibacterial-activity
#4
Virginia Fuochia, Giovanni Li Volti, Pio Maria Furneri
BACKGROUND: Gram positive bacteria produce peptides, defined bacteriocins which exhibit good antibacterial activity. OBJECTIVE: We evaluated the ability of L. fermentum to produce bacteriocins having therefore, good probiotic features and finally, be safe towards microglial cells. METHOD: Eight wild strains, identified using molecular techniques, were investigated for the evaluation of resistance to bile salts, low pH, H2O2 production, biofilm formation, antibacterial activity and safety on microglia cells (BV2)...
December 29, 2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28034293/low-concentrations-of-cationic-pamam-dendrimers-affect-lymphocyte-respiration-in-in-vitro-studies
#5
Magdalena Labieniec-Watala, Marzena Szwed, Joanna Hertel, Ewelina Wisnik
BACKGROUND: The effect of low concentrations of poly(amido)amine dendrimers (G2-G4) on human lymphocytes was studied. Some works revealed that PAMAMs can adversely affect the morphology of blood components and mitochondria functions. In this context, the present report aimed to investigate the in vitro cationic dendrimers' effect on mitochondrial respiration and cell morphology in lymphocytes isolated from human blood. METHODS: To monitor the mitochondria changes, the high-resolution respirometer was used...
December 29, 2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28034292/the-effect-of-pullulan-on-the-growth-and-acidifying-activity-of-selected-stool-microflora-of-human
#6
Anna Chlebowska-Śmigiel, Małgorzata Gniewosz, Marek Kieliszek, Anna Bzducha-Wróbel
BACKGROUND: Pullulan is a microbial polysaccharide of low energy value, which can component of low-calorie foods and in dietary snacks for diabetics. The objective of the study was to determine the effect of pullulan on the growth and fermentation activity of selected human intestinal bacteria. METHODS: Commercial pullulan purchased from Focubase (China) of a molecular weight of 100,000 Da constituted as experimental material. Food grade pullulan 99% purity. Two control media were prepared: the first standard RCM composed of (g/100 ml): 0...
December 29, 2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28017140/molecular-cellular-and-pharmaceutical-aspects-of-filling-biomaterials-during-the-management-of-extraction-sockets
#7
Antonio Barone, Fortunato Alfonsia, Valentina Borgia, Giovanna Iezzi, Adriano Piattelli, Ugo Covani, Paolo Tonelli
After a tooth extraction both hard and soft tissues undergo dimensional changes. The use of a ridge preservation technique at the moment of the tooth extraction could help could help to prevent the volume loss, thus simplifying the subsequent prosthetic and/or implant therapy. Some studies were conducted in order to examine the biomaterials and the surgical technique used for ridge preservation procedures. Clinical, histological, volumetric and molecular outcomes were registered and analysed in different studies, in order to comprehend the biological events and the consequences of a socket preservation procedure and to allow the clinician to make the correct choice...
December 23, 2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28003002/impact-of-different-implant-surfaces-topographies-on-peri-implant-tissues-an-update-of-current-available-data-on-dental-implants-retrieved-from-human-jaws
#8
Jamil Awad Shibli, Jefferson T Pires, Adriano Piattelli, Giovanna Iezzi, Carlo Mangano, Francesco Mangano, Sergio Luiz Scombati de Souza, Sergio A Gehrke, Hom-Lay Wang, David Dohan Ehrenfest
The high success range obtained with the implant-supported restorations has improved its applicability on routine of the daily clinical practice. This elevated percentage of success is related to the previous pre-clinical data obtained from animal and in vitro studies that evaluated the impact of implant surface topographies on bone tissue. However, the histologic evaluation of human bone tissue is scarce. Therefore, the aim of this review is to depict an actual panorama of the data available on bone-to-implant contact (BIC) of retrieved implants from human jaws...
December 21, 2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28003001/molecular-cellular-and-pharmaceutical-aspects-of-bone-grafting-materials-and-membranes-during-maxillary-sinus-lift-procedures-part-1-a-general-overview
#9
Adriano Piatelli, Giovanna Iezzi, Alessandra Giuliani, Carlo Mangano, Licia Manzon, Marco Degidi, Flavia Iaculli, Antonio Scarano, Antonella Filippone, Vittoria Perrotti
Sinus augmentation procedure has been demonstrated to be a highly predictable treatment in posterior maxilla atrophy. All the surgical interventions in the maxillary region require deep knowledge of anatomy and possible anatomical variations. In this article pre-operative and post- operative assessments of sinus cavity as well as novel approaches to deepen our knowledge of the behavior of bone substitute materials are described. The awareness of the patient's morphologic conditions enables exact planning of invasive surgery and aids to avoid complications...
December 21, 2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28002992/molecular-cellular-and-pharmaceutical-aspects-of-bone-grafting-materials-and-membranes-during-maxillary-sinus-lift-procedures-part-1-a-general-overview
#10
Adriano Piatelli, Giovanna Iezzi, Alessandra Giuliani, Carlo Mangano, Licia Manzon, Marco Degidi, Flavia Iaculli, Antonio Scarano, Antonella Filippone, Vittoria Perrotti
Sinus augmentation procedure has been demonstrated to be a highly predictable treatment in posterior maxilla atrophy. All the surgical interventions in the maxillary region require deep knowledge of anatomy and possible anatomical variations. In this article pre-operative and post- operative assessments of sinus cavity as well as novel approaches to deepen our knowledge of the behavior of bone substitute materials are described. The awareness of the patient's morphologic conditions enables exact planning of invasive surgery and aids to avoid complications...
December 21, 2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/27981899/high-hydrostatic-pressure-assisted-enzymatic-treatment-improves-antioxidant-and-anti-inflammatory-properties-of-phosvitin
#11
Heejoo Yoo, Fatemeh Bamdad, Naiyana Gujral, Joo-Won Suh, Hoon Sunwoo
BACKGROUND: Phosvitin (PV) is a highly-phosphorylated metal-binding protein in egg yolk. Phosphoserine clusters make PV resistant to enzymatic digestion, which might be nutritionally undesirable. OBJECTIVE: This study was designed to determine the effects of high hydrostatic pressure and enzymatic hydrolysis (HHP-EH) on the antioxidant and anti-inflammatory properties of PV hydrolysates (PVHs). METHODS: PV was hydrolyzed by alcalase, elastase, savinase, thermolysin, and trypsin at 0...
December 16, 2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/27978809/antibacterial-combination-of-oleoresin-from-copaifera-multijuga-hayne-and-biogenic-silver-nanoparticles-towards-streptococcus-agalactiae
#12
E S Otaguiri, Aeb Morguette, R P Biasi-Garbin, A T Morey, Cac Lancheros, D Kian, A G Oliveira, G Kerbauy, Mre Perugini, N Durán, C V Nakamura, V F Veiga Junior, G Nakazato, P Pinge-Filho, L M Yamauchi, S F Yamada-Ogatta
BACKGROUND: Streptococcus agalactiae (group B Streptococcus - GBS) remains a leading cause of neonatal infections and an important cause of invasive infections in adults with underlying conditions. METHODS: This study evaluated for the first time the effect of an oleoresin collected from Copaifera multijuga Hayne (copaiba oil) alone or in combination with silver nanoparticles produced by green synthesis using Fusarium oxysporum (AgNPbio) against planktonic and sessile cells of GBS isolated from colonized women...
December 13, 2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/27978808/molecular-cellular-and-pharmaceutical-aspects-of-biomaterials-in-dentistry-and-oral-and-maxillofacial-surgery-an-internationalization-of-higher-education-and-research-perspective
#13
Lidia M Wisniewska, David M Dohan Ehrenfest, Pablo Galindo-Moreno, Jesús Domingo Segovia, Francesco Inchingolo, Hom-Lay Wang, Manuel Fernándes-Cruz
In dentistry and oral and maxillofacial surgery, the development of implantable biomaterials and the understanding of their molecular, cellular and pharmaceutical aspects are currently major fields of research and education, with a considerable impact on the daily clinical practice and the evolution of therapeutic strategies. In the era of globalized economy of knowledge and science, this scientific domain needs the development of global cooperation and a paradigm evolution in the organizational culture of the dental sciences and related dental industry...
December 13, 2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/27928950/molecular-and-pharmaceutical-aspects-of-novel-methods-and-materials-for-the-prevention-of-tooth-structure-loss
#14
Laurence J Walsh
In the past decade, a range of dental products have appeared which make advertising claims around preventing mineral loss or repairing mineral loss. This review examines the requirements for effective protection of tooth structure, and the evidence around technologies now available for preventing tooth structure loss and repairing demineralized enamel, ranging from tooth surface protection and enhanced fluoride uptake through to calcium compounds, unstabilized amorphous calcium phosphate, tricalcium phosphate, and casein phosphopeptide - amorphous calcium phosphate...
December 7, 2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/27924724/delivery-systems-for-antimicrobial-peptides-and-proteins-towards-optimization-of-bioavailability-and-targeting
#15
Joana R Costa, Nádia C Silva, Bruno Sarmento, Manuela Pintado
Antimicrobial peptides (AMPs) and proteins are produced by a wide range of organisms as important elements of their defense mechanisms, forming a large number of antimicrobial compounds that can be used to treat several human infections. The potential for the use of AMPs and antimicrobial proteins in therapeutics is growing, but their application is often limited, due to their poor physical and/or chemical properties. In recent years, several drug delivery systems have been proposed to carry such molecules, in an attempt to overcome the difficulties regarding their properties...
December 7, 2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/27915982/molecular-cellular-and-pharmaceutical-aspects-of-bone-grafting-materials-and-membranes-during-maxillary-sinus-lift-procedures-part-2-detailed-characteristics-of-the-materials
#16
Giovanna Iezzi, Adriano Piatelli, Alessandra Giuliani, Carlo Mangano, Antonio Barone, Licia Manzon, Marco Degidi, Antonio Scarano, Antonella Filippone, Vittoria Perrotti
Various grafts or combination of bone substitute materials have been used in sinus lift procedures. Currently, ongoing developments in several disciplines, from molecular biology and chemistry to computer science and engineering, have contributed to the understanding of biological processes leading to bone healing after the use of bone substitute materials (BSBs) and therefore of the behavior of BSBs. The understanding of the properties of each graft enables individual treatment concepts and therefore allows shift from a simple replacement material to the modern concept of an individually created composite biomaterial...
December 1, 2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/27915981/molecular-cellular-and-pharmaceutical-aspects-of-autologous-grafts-for-peri-implant-hard-and-soft-tissue-defects
#17
Jiayu Lu, Yongming Hao, Wei Zhao, Chengqi Lv, Derong Zou
The lack of supporting hard and soft tissues always prevents the rehabilitation with dental implants. Among various hard and soft tissue augmentation procedures, autologous grafts have been considered to be the gold standard. Autologous mesenchymal stem cells (MSCs) from bone marrow, dental tissue and adipose tissue have been described as promising alternatives for bone regeneration in the field of dental implantation. Mucosal cells, gingival fibroblasts and dental progenitor cells (DPS) can enhance peri-implant soft tissue augmentation and regenerate periodontal tissues around dental implants...
December 1, 2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/27915980/molecular-cellular-and-pharmaceutical-aspects-of-synthetic-hydroxyapatite-bone-substitutes-for-oral-and-maxillofacial-grafting
#18
Werner Goetz, Spyridon N Papageorgiou
Bone grafts are widely used for augmentation procedures in oral and maxillofacial surgery, with autogenous bone being the gold standard. Recently, the focus of research has shifted towards synthetic bone substitutes, as no second surgery is needed and large quantities of graft can easily be provided. Within the broad range of bone substitutes, synthetic hydroxyapatite has drawn much attention, as they are considered to be biocompatible, non-immunogenic, osteoconductive and osteoinductive. Scope of this review is to summarize existing knowledge concerning the molecular, cellular and pharmaceutical aspects of synthetic bone substitutes for oral and maxillofacial grafting...
December 1, 2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/27855600/optimization-on-fc-for-improvement-of-stability-and-aggregation-resistance
#19
Xiaobo Chen, Fang Zeng, Tao Huang, Liang Cheng, Huan Liu, Rui Gong
Fc-based therapeutics including therapeutic full-size monoclonal antibodies (mAbs) and Fc-fusion proteins represent fastest-growing market in biopharmaceutical industrial. However, one major challenge during development of Fc-based therapeutics is how to maintain their efficacy in clinic use. Many factors may lead to failure in final marketing. For example, the stability and aggregation resistance might not be high enough for bearing the disadvantages during fermentation, purification, formulation, storage, shipment and other steps in manufacture and sale...
November 17, 2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/27855599/a-highly-polar-phytocomplex-involving-rutin-is-responsible-for-the-neuromuscular-facilitation-caused-by-casearia-sylvestris-gua%C3%A3-atonga
#20
Edson H Yoshida, Natália Tribuiani, Ameris L Foramiglio, Caroline A Foramiglio, Renata V da Silva Tavares, Tiago J Bonomini, Paula C P Bueno, Alberto J Cavalheiro, Stephen Hyslop, Pilar Puebla, Arturo S Feliciano, Yoko Oshima-Franco
Of the various biological activities ascribed to extracts from Casearia sylvestris (guaçatonga), its facilitatory activity, i.e., ability to increase skeletal muscle contractile amplitude, has promising therapeutic applications. In this work, we investigated the components responsible for the previously described neurofacilitation caused by C. sylvestris leaves. </p> <p> Methods: The methanolic fraction of C. sylvestris leaves was initially fractionated by column chromatography and partitioned in a MeOH:H2O gradient...
November 17, 2016: Current Pharmaceutical Biotechnology
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