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Current Pharmaceutical Biotechnology

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https://www.readbyqxmd.com/read/28914199/clinical-applications-of-intravenous-immunoglobulins-in-child-neurology
#1
Maria Gogou, Efimia Papadopoulou-Alataki, Martha Spilioti, Sofia Alataki, Athanasios Evangeliou
BACKGROUND: While there are guidelines for the use of intravenous immunoglobulins in children with Guillain-Barre syndrome and myasthenia gravis based on high-level evidence studies, data is fewer for the majority of neurologic disorders in this age group. Neuronal antibodies are detected in children with seizures of autoimmune etiology. Intravenous immunoglobulins with their broad immunomodulatory mechanism of action could be ideally effective in different forms of immune-dysregulated intractable epilepsies such as autoimmune epilepsy and autoimmune Rasmussen encephalitis...
September 15, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28914198/pemtb-a-database-of-mhc-antigenic-peptide-of-mycobacterium-tuberculosis
#2
Qamar Zia, Asim Azhar, Shadab Ahmad, Mohammad Afsar, Ziaul Hasan, Mohammad Owais, Mahfooz Alam, Shabab Akbar, Magdah Ganash, Ghulam Md Ashraf, Swaleha Zubair, Gjumrakch Aliev
BACKGROUND: For design of a subunit vaccine for tuberculosis, identification of antigenic T-cell epitope is of utmost importance. Several MHC prediction server are available that can accurately predict antigenic peptide of variable lengths. However, peptides predicted from one server not necessarily are predicted form another server, thus creating a confusing situation for scientists to choose a best epitope. METHOD: Keeping the above problem in mind, we developed a comprehensive database of peptides of Mycobacterial proteins...
September 14, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28914197/characterization-of-inherent-particles-and-mechanism-of-thermal-stress-induced-particle-formation-in-hsv-2-viral-vaccine-candidate
#3
Lillian Li, Marina Kirkitadze, Kamaljit Bhandal, Cristopher Roque, Eric Yang, Bruce Carpick, Nausheen Rahman
BACKGROUND: Vaccine formulations may contain visible and/or subvisible particles, which can vary in both size and morphology. Extrinsic particles, which are particles not part of the product such as foreign contaminants, are generally considered undesirable and should be eliminated or controlled in injectable products. However, biological products, in particular vaccines, may also contain particles that are inherent to the product. Here we focus on the characterization of visible and subvisible particles in a live, replication-deficient viral vaccine candidate against HSV genital herpes in an early developmental stage...
September 14, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28828981/the-primary-mechanism-of-cellular-internalization-for-a-short-cellpenetrating-peptide-as-a-nano-scale-delivery-system
#4
Betty R Liu, Yue-Wern Huang, Mallikarjuna Korivi, Shih-Yen Lo, Robert S Aronstam, Han-Jung Lee
BACKGROUND: Development of effective drug delivery systems (DDS) is a critical issue in health care and medicine. Advances in molecular biology and nanotechnology have allowed the introduction of nanomaterial-based drug delivery systems. Cell-penetrating peptides (CPPs) can form the basis of drug delivery systems by virtue of their ability to support the transport of cargoes into the cell. Potential cargoes include proteins, DNA, RNA, liposomes, and nanomaterials. These cargoes generally retain their bioactivities upon entering cells...
August 22, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28828982/development-of-benzimidazole-derivatives-as-novel-anti-platelet-drugs
#5
Wei-Cheng Yao, Lan-Ting Yuan, Wen-Bin Yang, Chih-Hsuan Hsia, Li-Ting Huang, Tzu-Yin Lee, Joen-Rong Sheu, Wan-Jung Lu, Thanasekaran Jayakumar, Ray-Jade Chen
BACKGROUND: Benzimidazoles are privileged biomolecules which form an integral part of vitamin B12 and have been attracting numerous researchers all over the world to assess their potential therapeutic significance. OBJECTIVES: The comparative in vitro antiplatelet activity of newly synthesized benzimidazole derivatives, M3BIM, C2BIM, and L2BIM in thrombin, adenosine diphosphate (ADP) and epinephrine-induced washed human platelets was investigated. METHODS: Reversed-phase silica gel column chromatography, Aggregometry, Flow cytometry and Immunoblotting were used in this study...
August 20, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28814229/cell-mediated-and-humoral-immune-responses-to-bordetella-pertussis-inactivated-whole-cells-encapsulated-alginate-microspheres-as-a-new-vaccine-candidate
#6
Naser Mohammadpour Dounighi, Fereshteh Shahcheraghi, Mehdi Razzaghi-Abyaneh, Mojtaba Nofeli, Hossein Zolfagharian
BACKGROUND: Effectiveness of the whole-cell pertussis vaccine is apparent, but improvement in the quality of the vaccine is necessary to achieve strong immunogenicity with a low bacterial number content. METHODS: The inactivated Bordetella pertussis (B. pertussis) cells entrapped microspheres were prepared via an emulsification method and analyzed for morphology, size, size distribution, loading efficiency, loading capacity, release kinetic, in vivo cytokines and antigen specific antibody subclasses...
August 15, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28799494/contribution-of-large-animals-to-translational-research-on-prenatal-programming-of-obesity-and-associated-diseases
#7
Antonio Gonzalez-Bulnes, Pascale Chavatte-Palmer
BACKGROUND: The awareness of factors causing obesity and associated disorders has grown up in the last years from genome to a more complicated concept (developmental programming) in which prenatal and early-postnatal conditions markedly modify the phenotype and homeostasis of the individuals and determine juvenile growth, life-time fitness/obesity and disease risks. Experimentation in human beings is impeded by ethical issues plus inherent high variability and confounding factors (genetics, lifestyle and socioeconomic heterogeneity) and preclinical studies in adequate translational animal models are therefore decisive...
August 11, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28786358/gonadotropin-releasing-hormone-agonists-or-antagonists-for-preimplantation-genetic-diagnosis-pgd-a-prospective-randomised-trial
#8
W Verpoest, A De Vos, M De Rycke, S Parikh, C Staessen, H Tournaye, M De Vos, V Vloeberghs, C Blockeel
Background The use of GnRH analogue medication is essential in reproductive medicine to avoid premature ovulation by pituitary suppression for the duration of ovarian stimulation by gonadotrophins. The type of pituitary suppression by either GnRH agonist analogues versus GnRH antagonist analogues may result in different embryological hence clinical results. Preimplantation genetic diagnosis is a subtype of IVF in which embryos are created for genetic diagnosis of hereditary disorders in order to avoid genetically affected children...
August 8, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28786357/tocotrienols-stimulate-insulin-secretion-of-rat-pancreatic-isolated-islets-in-a-dynamic-culture
#9
Ling Li Chia, Ibrahim Jantan, Kien Hui Chua
BACKGROUND: Tocotrienols (T3) are the natural occurring vitamin E derivatives that possess antioxidant properties and therapeutic potential in diabetic complications. The bioactivities of the derivatives are determined by the number and arrangement of methyl substitution on the structure. OBJECTIVE: The objective of this study was to determine the effects of T3 derivatives, δ-T3, γ-T3 and α-T3 on insulin secretion of rat pancreatic islets in a dynamic culture...
August 8, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28786356/therapeutic-enzymes-applications-and-approaches-to-pharmacological-improvement
#10
Maryam Yari, Mohammad Bagher Ghoshoon, Bahareh Vakili, Younes Ghasemi
BACKGROUND: Among therapeutic proteins, enzymes represent small and of course profitable market. They can be used to treat important, rare, and deadly diseases. Enzyme therapy is the only available treatment for certain disorders. METHODS: Here, pharmaceutical enzymes are reviewed. They are categorized in four main groups, enzymes in replacement therapy, enzymes in cancer treatment, enzymes for fibrinolysis, and finally enzymes that are used topically for various treatments...
August 8, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28786355/the-impact-of-elevated-progesterone-at-the-initiation-of-an-artificially-prepared-frozen-embryo-transfer-cycle-a-case-series
#11
Drakopoulos Panagiotis, Mat Corina, P Polyzos Nikolaos, Santos-Ribeiro Samuel, Arne van de Vijver, Liesbet Van Landuyt, Tournaye Herman, Blockeel Christophe
BACKGROUND: The role of elevated baseline progesterone (P) levels on outcomes of frozen embryo transfers (FET) performed in an artificial cycle has not been investigated yet. OBJECTIVE: To evaluate the role of elevated P in artificial FET Method: Case series study of 12 patients with high P levels undergoing artificial FET recruited during a 6-month period in a tertiary referral center Results: The clinical pregnancy rate per transfer was 4/12 (33.3%). The biochemical pregnancy rate was 6/12 (50...
August 8, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28786354/random-start-ovarian-stimulation-for-oocyte-or-embryo-cryopreservation-in-women-desiring-fertility-preservation-prior-to-gonadotoxic-cancer-therapy
#12
Rachel B Danis, Nigel Pereira, Rony T Elias
BACKGROUND: Women of reproductive age diagnosed with cancer are often interested in preserving gametes or reproductive tissue that would allow for future genetic parenthood. Preservation of fertility is often accomplished in young cancer patients via ovarian stimulation followed by oocyte or embryo cryopreservation. Conventional stimulation protocols, however, require 2-4 weeks to complete ovarian stimulation, oocyte retrieval and possible fertilization. Such a strategy may not be feasible in patients requiring urgent cancer treatment...
August 8, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28699481/editorial-circulating-biomarkers-in-cardiovascular-diseases-a-field-of-theoretical-research-or-realistic-clinical-application
#13
EDITORIAL
Michael Behnes, Ibrahim Akin
No abstract text is available yet for this article.
July 10, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28699480/adulteration-practices-of-psychoactive-illicit-drugs-an-updated-review
#14
Renata Solimini, Maria Concetta Rotolo, Manuela Pellegrini, Adele Minutillo, Roberta Pacifici, Francesco Paolo Busardò, Simona Zaami
BACKGROUND: It is well known that powdery drugs such as cocaine and heroin are frequently adulterated or diluted predominantly to obtain more doses and to increase the drug dealer's profits, but also to enhance, to modify or to oppose drug effects. METHODS: The aim of this report is to provide an overview of the recent scientific literature on medicines as well as on new psychoactive substances, used as cutting agents (i.e. pharmacologically active adulterants) and on the related adverse health effects on consumers, possibly due to the synergistic effect of the adulterants laced with substances of abuse, which represent a matter of great concern because of the frequent fatalities...
July 10, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28685688/anti-oxidative-and-anti-microbial-activities-of-purified-mpn-1-1-from-persicaria-nepalensis-meisn-miyabe
#15
Woong-Suk Yang, Seung-Hoon Yang, Jae-Yong Lee, Seong-Ho Jang, Cheorl-Ho Kim, Cher-Won Hwnag
BACKGROUND: Persicaria is a genus of flowering plants generally used for traditional medicine and nutritional supplements in tropical and subtropical East Asian countries. Previous studies have shown that Persicaria extracts alleviate lipid peroxidation, hypertension, and inflammation. OBJECTIVE: We investigated the anti-oxidative and anti-microbial effects of ethanol extracts of Persicaria nepalensis (Meisn.) Miyabe, and isolated and identified an active compound, MPN-1-1 from the ethanol extracts...
July 5, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28545359/microbial-enzymatic-degradation-of-biodegradable-plastics
#16
Roohi, Kulsoom Bano, Mohammed Kuddus, Mohd Rehan Zaheer, Qamar Zia, Mohd Farhan Khan, Ghulam Md Ashraf, Gjumrakch Aliev
Background The use of different types of plastics in the world either synthetic or biodegradable has become a part in all sectors of the economy. Infrastructure such as agriculture, building and construction, telecommunication, consumer goods, packaging, health and medical are all high growth areas that ensure a spiralling demand for plastics. Lack of degradability, environmental pollution and closing of landfill sites has led to concern more about plastic waste disposal. Appropriate biodegradation should occur for these water-immiscible polymers since they eventually enter streams which can neither be recycled nor incinerated and also not despoiled with existing physical and chemical means of degradation...
May 23, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28545358/molecular-imaging-of-tumor-angiogenesis-and-therapeutic-effects-with-dual-bioluminescence
#17
Ran Wang, Kaiyue Zhang, Hongyan Tao, Wei Du, Di Wang, Ziwei Huang, Manqian Zhou, Yang Xu, Yuebing Wang, Na Liu, Hui Wang, Zongjin Li
BACKGROUND: Angiogenesis is critical for the growth of tumor by supplying nutrients and oxygen that exacerbates the metastasis and progression of cancer. Noninvasive imaging of angiogenesis during the tumor therapeutic processes may provide novel opportunities for image-guided tumor management. OBJECTIVE: Here, we want to develop a mouse animal model for assessing cancer progression and angiogenesis in the same individuals by molecular imaging. METHODS: Breast cancer model was developed with mouse breast cancer cell line 4T1 carrying a reporter system encoding a triple fusion (TF) reporter gene consisting of renilla luciferase (Rluc), red fluorescent protein (RFP) and herpes simplex virus truncated thymidine kinase (HSV-ttk) in transgenic mice, which expressed firefly luciferase (Fluc) under the promoter of vascular endothelial growth factor receptor 2 (Vegfr2-luc)...
May 23, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28524000/the-effect-of-a-common-antibiotics-doxycycline-on-non-healing-chronic-wound
#18
Dixon H Xu, Ziwen Zhu, Yujiang Fang
Up to 25% of diabetic patients will develop a diabetic foot ulcer. Chronic wounds such as diabetic foot ulcers often fail to heal with conventional therapies. In recent years, it has been identified that chronic wounds are usually associated with elevated level of matrix metalloproteinases (MMPs). Doxycycline, a cheap tetracycline antibiotic, has been shown to inhibit MMPs both in vitro and in vivo independent of its antimicrobial property. In this review, we provide an overview of the roles of MMPs in the pathogenesis of chronic wounds and explore the potential application of doxycycline as a treatment option in managing chronic wounds such as diabetic foot ulcers...
May 18, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28482785/microemulsions-for-protein-delivery-loading-optimization-and-stability
#19
Diego R Perinelli, Marco Cespi, Stefania Pucciarelli, Silvia Vincenzetti, Luca Casettari, Jenny K W Lam, Serena Logrippo, Elisa Canala, Mahmoud E Soliman, Giulia Bonacucina, Giovanni F Palmieri
BACKGROUND: Microemulsions are attractive delivery systems for therapeutic proteins and peptides due to their ability to enhance bioavailability. Although different proteins and peptides have been successfully delivered through such ternary systems, no information can be found about protein loading and the formulation stability when such microemulsions are prepared with pharmaceutically-approved oils and surfactants. The aim of this work was to optimise a ternary system consisting of water/ethyl oleate/Span 80-Tween 80 and to determine its protein loading capacity and stability, using bovine serum albumin (BSA) as a model of biomolecule...
May 7, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28464772/encapsulation-in-cell-therapy-methodologies-materials-and-clinical-applications
#20
P Gálvez-Martín, M J Martin, M A Ruiz, B Clares
The clinical application of cells and the development of new delivery systems have allowed significant advances in the field of cell therapy and encapsulation in recent years. The ability to combine cells and biocompatible matrices in the encapsulation of cells providing long-term delivery has provided new therapeutic alternatives in the development of new therapies. Cell encapsulation provides increased retention time in the target tissue improving its therapeutic efficacy. This technology involves the development of a physical barrier (natural or synthetic matrix surrounded by a semipermeable membrane) to isolate and protect cells from the host's immune system maintaining the microenvironment of embedded cells, their viability and their capacity of differentiation, improving their function in vivo, and reducing side effects associated with the use of immunosuppressive therapy...
May 1, 2017: Current Pharmaceutical Biotechnology
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