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Current Pharmaceutical Biotechnology

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https://www.readbyqxmd.com/read/30398114/scorpion-toxins-targeting-voltage-gated-sodium-channels-associated-with-pain
#1
Yijia Xu, Junxin Sun, Hongyu Liu, Jianfang Sun, Yue Yu, Yang Su, Yong Cui, Mingyi Zhao, Jinghai Zhang
Pain affects approximately 30% of people and places a large economic and social burden on society. Despite the availability of a range of analgesics, complete alleviation of symptoms are still rarely occurred. Effective and safe drugs for the treatment of pain are still an unmet clinical need. In recent years, the voltage-gated sodium channels (VGSCs) have been recognized as potential targets for analgesic development. VGSCs are major players in generating and propagating action potentials. They represent an appealing target for the development of new and safer drugs in the treatment of pain...
November 5, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/30381071/erythropoietin-directly-affects-human-macrophage-functionality
#2
O V Melashchenko, M E Meniailo, V V Malashchenko, N D Gazatova, A G Goncharov, G V Seledtsova, V I Seledtsov
We studied direct effects of erythropoietin (Epo) on functional properties of human monocytes/macrophages (Mc/Mphs) in vitro. Cells expressing CD14 marker (a co-receptor for bacterial LPS) were isolated from human peripheral blood mononuclear cells (PBMCs) by positive magnetic separation. We showed that Epo treatment reduce the percentages of CD14+ cells, CD124 (alpha subunit of IL-4 receptor)+ cells and CD197 (CCR7) + cells in non-activated Mph cultures without affecting the levels of CD16 (low-affinity Fc-receptor)+ and CD119 (interferon-γ (IFN-γ) receptor)+ cells...
October 31, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/30381070/the-association-of-fractalkine-receptor-t280m-polymorphism-in-the-pathogenesis-of-acute-coronary-syndrome-in-the-egyptian-population
#3
Dina S Hassan, Ingy M Hashad, Mohamed F Abdel Rahman, Sahar M Abdel-Maksoud
BACKGROUND: Fractalkine (FKN) in its free and membrane bound-forms, and its receptor CX3CR1are reported to have an atherosclerotic effect. The relationship of single nucleotide polymorphisms (SNPs) in FKN and CX3CR1genes with the coronary artery disease (CAD) risk showed conflicting results in different populations. The aim of this study was to investigate the influence of CX3CR1 threonine 280 methionine (T280M) polymorphism in the predisposition of Acute Coronary Syndrome (ACS) in Egyptians...
October 31, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/30381069/screening-and-identification-of-ssdna-aptamers-against-hn-protein-for-detection-of-bovine-parainfluenza-virus-type-3-antibodies-in-serum
#4
J Cheng, J W Wang, Y Liu, Q M Wu, Z Wang
Bovine parainfluenza virus type 3 (BPIV3) is a major but often overlooked pathogen that causes respiratory disease in cattle, especially during transportation and in feedlot situations. In the present study, ssDNA aptamers with high affinity and specificity against the HN protein of BPIV3 were selected using microplates as the matrix. After eleven rounds selection, thirty-four different DNA sequences were obtained in total, wherein w-32, w-33, and w-34 were repeated seven, eleven, and nine times, and with Kd values of 56...
October 31, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/30378495/factors-regulating-human-extravillous-trophoblast-invasion-chemo-kine-peptidase-and-cd9-integrin-systems
#5
Hiroshi Fujiwara, Hisanori Matsumoto, Yukiyasu Sato, Akihito Horie, Masanori Ono, Mitsuhiro Nakamura, Yasunari Mizumoto, Kyosuke Kagami, Tomoko Fujiwara, Akira Hattori, Yoshiko Maida, Takiko Daikoku, Kazuhiko Imakawa, Yoshihiko Araki
The invasion of an extravillous trophoblast (EVT) into maternal decidual tissues, especially toward maternal spiral arteries, is an essential process in human placental formation and subsequent normal fetal development. However, the precise regulatory mechanisms to induce EVT invasion toward arteries and/or to protect EVT from further invasion are not well understood. We found that a chemokine receptor, CCR1, was specifically expressed on EVT migrating toward maternal arteries. Using EVT isolated from a primary villous explant culture, RANTES, which is one of the ligands for CCR1, was shown to enhance EVT invasion...
October 29, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/30370844/anti-inflammatory-effects-of-variola-virus-tnf-decoy-receptor-in-experimental-model-of-contact-dermatitis
#6
Elena A Viazovaia, Irina P Gileva, Ludmila B Toporkova, Sergei N Shchelkunov, Irina A Orlovskaya
Large DNA poxviruses encode a diverse family of secreted proteins that modulate host inflammatory and antiviral responses, in particular by inhibiting one of the key players of the mammalian immune system, the tumor necrosis factor (TNF). We investigated the effects of a recombinant variola (smallpox) virus TNF-decoy receptor (VARV-CrmB) in a murine model of contact dermatitis. Our results demonstrate that the VARV-CrmB protein significantly reduces the 2,4-dinitrochlorbenzene (DNCB)-induced migration of skin leukocytes during the sensitization phase and suppresses ear oedema during the elicitation phase of the contact reaction...
October 29, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/30370843/a-microplate-based-platform-with-immobilized-human-glutathione-transferase-a1-1-for-high-throughput-inhibitor-screening
#7
Evangelia G Chronopoulou, Nikolaos E Labrou
Glutathione transferases (GSTs) catalyze the conjugation of glutathione (GSH) to endogenous and xenobiotic electrophilic compounds and have been involved in the development of resistance toward cancer chemotherapeutic drugs and in the etiology, pathology and progression of several other diseases. In the present work, the human isoenzyme GSTA1-1 (hGSTA1-1) was used to assemble a microplate-based platform for high-throughput screening of inhibitors from plant extracts. The enzyme was immobilized using sol-gel chemistry and deposited as a layer at the bottom surface of 96-well format ELISA microplate...
October 28, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/30345914/extracellular-production-of-a-potent-and-chemical-resistant-nattokinase-in-immobilized-escherichia-coli-using-response-surface-methodology
#8
Fatemeh Mohammadi, Navid Nezafat, Aydin Berenjian, Manica Negahdaripour, Mozhdeh Zamani, Mohammad Bagher Ghoshoon, Mohammad Hossein Morowvat, Shiva Hemmati, Younes Ghasemi
Nattokinase is a potent fibrinolytic protease, besides various industrial applications used as a drug for treatment or a supplement for preventing thrombosis. Generally, most of native extracellular proteins such as nattokinase from B.subtilis are lysed by some secretory proteases. Therefore, one way for solving this problem, is to apply other hosts for nattokinase production. There are different factors for producing secretory form of nattokinase from B.subtilis, such as suitable host, optimized media for the maximum activity and easy purification which are studied in this investigation...
October 22, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/30332949/circulating-endothelial-progenitor-cells-biology-and-regenerative-medicine-in-pulmonary-vascular-diseases
#9
Germano Guerra, Fabio Perrotta, Gianluca Testa
Pulmonary vascular disorders (PVDs) include primary or secondary diseases who influence the right heart function. Several researches showed that stem and progenitor cells may represent a novel approach in treating pulmonary hypertension. In particular, circulating endothelial progenitor cells (EPCs) are mobilized either from the bone marrow and/or arteries to replace dysfunctional endothelial cells and restore blood perfusion to ischemic tissues. They may deliver paracrine signals to stimulate local angiogenesis or may be physically incorporated within neovessels...
October 17, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/30332948/exosome-like-nanovesicles-isolated-from-citrus-limon-l-exert-antioxidative-effect
#10
Nicola Baldini, Elena Torreggiani, Laura Roncuzzi, Francesca Perut, Nicoletta Zini, Sofia Avnet
BACKGROUND: Exosome-like nanovesicles are biological nanostructures mediating cell-to-cell communication and capable to load selected cargos also in the interaction among different species. OBJECTIVE: We aimed to explore the content of exosome-like nanovesicles derived from Citrus limon L. and to analyze the effects of their uptake on human cells. METHOD: We isolated exosome-like nanovesicles from Citrus limon L. juice (EXO-CL) by differential centrifugation...
October 17, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/30332947/leukocyte-independent-effects-of-cc-chemokines-on-vascular-remodeling
#11
Sara Paccosi, Astrid Parenti
Vascular remodeling is an alteration in the structure of vessels in response to injury or hemodynamic changes. Disturbance of the structural and functional integrity of the endothelial cell layer can be observed in vascular remodeling associated with inflammation. Chemokines have been implicated in a wide range of diseases with prominent inflammatory components, and also in vascular remodeling. Among them, CC-chemokines are of great interest. They act through conventional CC-chemokine receptors (CCRs), widely expressed by leucocytes and especially monocytes, which are attracted to sites of chronic inflammation...
October 17, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/30332946/enzymatic-hydrolysis-of-hyaluronic-layer-before-drug-dosing
#12
Anna Trusek-Holownia, Anita Niesobska, Damian Semba
Polymeric drug delivery system, allowing the controlled long-term drug release, is a good alternative to the standard way (oral or intravenous) of pharmaceuticals' administration. The most widespread drug release strategy is based on the drug molecules diffusion: first inside the carrier, then through the external layers of carrier and then, outside the carrier, to the cells surrounding. The proposed type of the local therapy is a particularly proper approach in treatment of cancer diseases, at which the drugs are highly toxic...
October 17, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/30332945/comparative-molecular-characterization-to-reveal-surface-behaviour-of-non-proteolytic-bromelain-mutants
#13
G Soundhara Rajan, Ankita Sharma, Pooja Kumari, Sagarika Biswas
Rheumatoid Arthritis (RA) is a chronic autoimmune disease that results in the systemic inflammation principally affecting the capsule covering the articulating ends of the synovial joints. Pharmacological treatment involving analgesics and anti-inflammatory drugs including steroids suppress the symptoms and have no effect on disease progression. However, disease modifying anti rheumatic drugs (DMARD) used for the treatment were still analysed for their long term effects. Bromelain has been widely used as phytotherapeutic drug owing to its anti-inflammatory, analgesic, anti-tumor and fibrinolytic properties...
October 17, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/30336770/gastroduodenal-disorders-in-patients-with-cvid-undergoing-immuno-globulin-therapy
#14
Gilda Varricchi, Antonio Pecoraro, Ludovica Crescenzi, Giancarlo Marone, Antonio Travaglino, Francesco Paolo D'Armiento, Arturo Genovese, Giuseppe Spadaro
BACKGROUND: Common variable immunodeficiency (CVID) encompasses a heterogeneous group of primary antibody deficiency disorders characterized by recurrent infections, autoimmunity and malignancies. Gastrointestinal manifestations are frequently associated with CVID. OBJECTIVE: In this cross-sectional study, we evaluated gastric and duodenal involvement in a cohort of adult patients with CVID. METHODS: Upper gastrointestinal endoscopy was performed in 58 patients (26 males, mean age 47...
October 10, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/30317995/probiotic-supplementation-and-topical-application-in-the-treatment-of-pediatric-atopic-dermatitis
#15
Monika Marcinkowska, Agnieszka Zagorska, Nikola Fajkis, Marcin Kołaczkowski, Pawel Pasko
Atopic dermatitis is a chronic inflammatory skin disease that commonly presents in early childhood. To date, the pharmacological treatment of atopic dermatitis is far from ideal, poses several limitations and constantly requires novel approaches. The theory that appropriate colonization of gut bacteria during infancy, influences the development of the immune system has initiated numerous clinical trials that evaluated the effectiveness of probiotic supplementation for the prevention and treatment of atopic eczema in children...
October 8, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/30295188/identification-and-characterization-of-genes-in-curcuminoid-pathway-of-curcuma-zedoaria-roscoe
#16
Truong Thi Phuong Lan, Nguyen Duc Huy, Nguyen Ngoc Luong, Nguyen Van Nghi, Trinh Huu Tan, Le Viet Quan, Nguyen Hoang Loc
BACKGROUND: Curcuminoid genes have an important role in the biosynthesis of curcumin, a valuable bioactive compound, in Curcuma species. However, there have not been any reports of these genes in Curcuma zedoaria. OBJECTIVE: The present work reports on the isolation of genes encoding enzymes in curcuminoid metabolic pathway and their expression in C. zedoaria. METHOD: The primers were designed from untranslation regions of DCS, CURS1, CURS2 and CURS3 genes which involve in curcuminoid biosynthesis in C...
October 8, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/30264676/circulating-endothelial-progenitor-cells-biology-and-regenerative-medicine-in-pulmonary-vascular-diseases
#17
Germano Guerra, Fabio Perrotta, Gianluca Testa
Pulmonary vascular disorders (PVDs) include primary or secondary diseases who ultimately influence the right heart function. Several researches showed that stem and progenitor cells may represent a novel approach in treating pulmonary hypertension. In particular, circulating endothelial progenitor cells (EPCs) are mobilized either from the bone marrow and/or arteries to replace dysfunctional endothelial cells and restore blood perfusion to ischemic tissues. They may deliver paracrine signals to stimulate local angiogenesis or may be physically incorporated within neovessels...
September 27, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/30255753/angiogenic-imbalance-as-a-contributor-of-preeclampsia
#18
Weronika Dymara-Konopka, Marzena Laskowska, Anna Blazewicz
Preeclampsia is one of the most serious pregnancy - specific medical conditions affecting 3-6% of all gestations. It remains a leading cause of maternal and fetal morbidity and mortality. The aetiology of preeclampsia is not fully elucidated yet, although a huge progress has been made in its understanding within the last decade. Numerous studies have provided compelling evidence that an excess of some antiangiogenic molecules released by the placenta to maternal circulation, in particular soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sEng) and decreased levels of proangiogenic substances like placental growth factor (PlGF) and vascular endothelial growth factor A (VEGF-A) play a key role in the pathogenesis of preeclampsia...
September 25, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/30255752/the-role-of-agonistic-autoantibodies-to-the-angiotensin-ii-type-1-receptor-at1-aa-in-pathophysiology-of-preeclampsia
#19
Nathan Campbell, Babbette LaMarca, Mark W Cunningham
Preeclampsia is the leading cause of death and morbidity world-wide for the mother and fetus during pregnancy. Preeclampsia does not only effect the mother and the baby during pregnancy, but can also have long-term effects, such as the increase risk of hypertension and cardiovascular disease, on the offspring and the postpartum mother later in life. The exact cause of preeclampsia is unknown, but women with preeclampsia have elevated concentrations of agonistic autoantibodies against the angiotensin II type 1 receptor (AT1-AA)...
September 25, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/30255751/preeclampsia-current-management-and-future-approach
#20
Weronika Dymara-Konopka, Marzena Laskowska, Jan Oleszczuk
Preeclampsia is one of the most serious pregnancy - specific medical conditions of increasing incidence. It remains a major cause of maternal and fetal morbidity and mortality. Although maternal mortality is especially high in developing countries, preeclampsia and its complications are one of the top four causes of maternal deaths even in developed societies. Unfortunately, yet the only effective and definitive treatment of preeclampsia is delivery of the baby and placenta, and its time depends on the disease severity and gestational age...
September 25, 2018: Current Pharmaceutical Biotechnology
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