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Current Pharmaceutical Biotechnology

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https://www.readbyqxmd.com/read/28183244/personalised-healthcare-the-dima-clinical-model
#1
Marina Borro, Giovanna Gentile, Vittorio Fineschi, Zeno Földes-Papp, Paola Frati, Alessandro Santurro, Luana Lionetto, Maurizio Simmaco
Large-scale application of Personalized Medicine requires a multi-disciplinal environment allowing synergic cooperation among different competences. Strict collaboration between medical and medical sciences, as informatics, ethics, politics, are needed to face the challenges of one-sized healthcare. In spite of the increasing interest, how this system can be globally realized remains tentative. Yet, a relatively small, Personalised Healthcare Service is providing a proof-of principle organizational model to guide implementation into clinical practice...
February 8, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28176639/personalized-medicine-in-the-paediatric-population-the-balance-between-pharmacogenetics-progress-and-bioethics
#2
Stefania Schiavone, Margherita Neri, Cristoforo Pomara, Irene Riezzo, Luigia Trabace, Emanuela Turillazzi
Personalized medicine (PM) is becoming increasingly important in contemporary clinical and research scenarios. In the context of PM, pharmacogenomics and pharmacogenetics are aimed at the genetic personalization of drug response. Extrinsic and intrinsic factors may explain inter-individual variability in drug response. Among such factors, age seems to specifically intervene to modulate drug response since normal developmental changes may influence the exposure-response relation. Consequently, the potential benefit of pharmacogenomics (PGx) in the paediatric population is considerable...
February 7, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28176638/personalized-medicine-and-adverse-drug-reactions-the-experience-of-an-italian-teaching-hospital
#3
Raffaele La Russa, Vittorio Fineschi, Mariantonia Di Sanzo, Vittorio Gatto, Alessandro Santurro, Gabriella Martini, Matteo Scopetti, Paola Frati
The personalized medicine is a model of medicine based on inherent difference given by the genetic heritage that characterizes us, diversity that can affect also our response to administered therapy. Nowadays, the term "adverse drug reaction" is identified with any harmful effect involuntary resulting from the use of a medicinal product; pharmacogenomics, in this field, has the aim to improve the drug response and to reduce the adverse reaction. We analyzed all reports of adverse reaction collected in the Pharmacovigilance Centre database of an Italian University Hospital, at the Sant'Andrea Hospital Sapienza University of Rome, in a period of two years...
February 7, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28176637/personalized-medicine-applied-to-forensic-sciences-new-advances-and-perspectives-for-a-tailored-forensic-approach
#4
Alessandro Santurro, Anna Maria Vullo, Marina Borro, Giovanna Gentile, Raffaele La Russa, Maurizio Simmaco, Paola Frati, Vittorio Fineschi
Personalized medicine (PM), included in P5 medicine (Personalized, Predictive, Preventive, Participative and Precision medicine) is an innovative approach to the patient, emerging from the need to tailor and to fit the profile of each individual. PM promises to dramatically impact also on forensic sciences and justice system in ways we are only beginning to understand. The application of omics (genomic, transcriptomics, epigenetics/imprintomics, proteomic and metabolomics) is ever more fundamental in the so called "molecular autopsy"...
February 7, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28164757/bone-micrornas-and-aging
#5
Janja Marc, Barbara Ostanek, Tilen Kranjc
The decline of tissue function in ageing is a consequence of many changes in the gene expression and other extrinsic factors. The molecular mechanisms underlying these changes are heavily investigated with focus on regulation of time-lapse gene expression. microRNAs, short non-coding RNA molecules are among the major regulators of gene expression. microRNAs have been shown to control ageing-related mechanisms and several evidence suggest age-related changes in microRNA transcriptome. However, the source regulator of time-lapse gene expression control still remains unknown...
February 2, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28155605/met-activating-genetically-improved-chimeric-factor-1-promotes-angiogenesis-and-hypertrophy-in-adult-myogenesis
#6
Flavio Ronzoni, Gabriele Ceccarelli, Ilaria Perini, Laura Benedetti, Daniela Galli, Francesca Mulas, Martina Balli, Giovanni Magenes, Riccardo Bellazzi, Gabriella Cusella De Angelis, Maurilio Sampaolesi
BACKGROUND: Myogenic progenitor cells (activated satellite cells) are able to express both HGF and its receptor cMet. After muscle injury, HGF-Met stimulation promotes activation and primary division of satellite cells. MAGIC-F1 (Met-Activating Genetically Improved Chimeric Factor-1) is an engineered protein that contains two human Met-binding domains that promotes muscle hypertrophy. MAGIC-F1 protects myogenic precursors against apoptosis and increases their fusion ability enhancing muscle differentiation...
February 1, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28137221/methoxy-polyethylene-glycol-epoetin-beta-as-a-novel-erythropoiesis-stimulating-agent-with-possible-nephroprotective-and-cardiovascular-protective-effects-in-non-dialysis-chronic-kidney-disease-patients
#7
Bartnicki Piotr, Stępień Mariusz, Rysz Jacek
Chronic kidney disease (CKD) is an important health problem, because of unsuccessful outcomes such as CKD progression to end stage renal disease and high risk of cardiovascular disease (CVD). Anemia, associated with CKD, is considered a non-traditional risk factor for CVD which may contribute to faster CKD progression. Anemia treatment with erythropoiesis-stimulating agents (ESAs) seems to exert non-hematopoietic effects on different tissues and organs, including cardiovascular system and kidneys. On the other hand, clinical use of high doses of short-acting ESAs and higher target hemoglobin level were associated with higher risk of CVD...
January 26, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28137220/multiwalled-carbon-nanotube-chitosan-scaffold-cytotoxic-apoptotic-and-necrotic-effects-on-chondrocyte-cell-lines
#8
Sibel Ilbasmis-Tamer, Hakan Çiftçi, Mustafa Tu Rk, Tuncer Degim, Uğur Tamer
BACKGROUND: Carbon nanotubes (CNTs) have been considered highly successful and proficient in terms of their mechanical, thermal and electrical functionalization and biocompatibility. In regards to their significant extent in bone regeneration, it has been determined that CNTs hold the capability to endure clinical applications through bone tissue engineering and orthopedic procedures. In the present study, we report on a composite preparation, involving the use of CNT-chitosan as scaffold for bone repair and regeneration...
January 26, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28117005/pharmacogenomic-challenges-in-cardiovascular-diseases-examples-of-drugs-and-considerations-for-future-integration-in-clinical-practice
#9
Jérôme Chatelin, Maria G Stathopoulou, Alex-Ander Aldasoro Arguinano, Ting Xie, Sophie Visvikis-Siest
Introduction Even if cardiovascular disease (CVD) drugs are supported by high level proofs, the results of CVD treatment present great disparities: there are still patients dying with supposed optimal treatment, patients facing adverse events and CVD remain the primary cause of death in the world. Pharmacogenomics is the basis of personalisation of the treatment able to allow higher medication success rates. In this review, we will present detailed examples of CVD drugs to highlight the complexity of this challenging field and we will discuss novel concepts that should be considered for a fastest integration of pharmacogenomics in clinical practice of CVD...
January 23, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28190384/lactic-acid-bacteria-with-concomitant-il-17-il-23-and-tnf%C3%AE-binding-ability-for-the-treatment-of-inflammatory-bowel-disease
#10
Staša Kosler, Borut Štrukelj, Aleš Berlec
BACKGROUND: Neutralization of proinflammatory cytokines is an established strategy in the treatment of inflammatory bowel disease (IBD). Systemic anti-TNFα antibodies have been used in the clinics for several years, while anti-IL-17/IL-23 antibodies have been less successful so far. We report the development of safe lactic acid bacterium Lb. salivarius with the ability to simultaneously bind IL-17A, IL-23 and TNFα that could be administered orally for the treatment of IBD. METHODS: Three different cytokine-binding non-Ig scaffolds (anti-IL-17A fynomer, anti-IL-23-binding adnectin and anti-TNFα-binding affibody) were cloned and expressed in L...
10, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28056729/editorial-molecular-cellular-and-pharmaceutical-aspects-of-biomaterials-in-dentistry-and-oral-and-maxillofacial-surgery-international-cooperation-translational-research-and-transdisciplinarity
#11
D M Dohan Ehrenfest, Lidia M Wisniewska, Agata Cieslik-Bielecka, Hom-Lay Wang, Manuel Fernándes-Cruz
No abstract text is available yet for this article.
4, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28056728/antimicrobial-effectiveness-of-synthesized-bioactive-silver-nanoparticles-by-the-actinomycetes-hgg16n-strain
#12
Bogusław Buszewskia, Viorica Railean-Plugarua, Paweł Pomastowski, Katarzyna Rafińskaa, Malgorzata Szultka-Mlynskaa, Tomasz Kowalkowskia
BACKGROUND: Biologically synthetized silver nanoparticles are promising antimicrobial agent. Flow cytometry, well diffusion methods, colony-forming units (CFU) and spectroscopic approach are commonly used in antimicrobial study. The aims of this study were to provides information about effectiveness of BioAgNPs synthesized by Actinomycetes HGG16n using fluorescence flow cytometry method as an alternative to the standard ones (well and disc diffusion method). METHODS: It was applied flow cytometry technique to monitor the antibacterial effect of biocolloidal silver and its combination with various commercial antibiotics against selected pathogens...
January 4, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28044932/ubiquitous-pharmacogenomics-u-pgx-the-time-for-implementation-is-now-an-horizon2020-program-to-drive-pharmacogenomics-into-clinical-practice
#13
Erika Cecchin, Rossana Roncato, Hendrik Jan Guchelaar, Giuseppe Toffoli, and for the Ubiquitous Pharmacogenomics Consortium
Although the clinical validity of a number of pharmacogenetic markers is nowadays a matter of fact, and led authoritative scientific consortia as the Dutch Pharmacogenetic Working Group (DPWG) and the Clinical Pharmacogenomics Implementation Consortium (CPIC) to publish pharmacogenetic guidelines, the clinical implementation in the real life remains challenging. Ubiquitous Pharmacogenomics (U-PGx) program is a coordinated effort that put together scientific and clinical expertise in the pharmacogenomic field, to implement the pre-emptive pharmacogenomic approach in the clinical practice in Europe, and to demonstrate its benefit in both patients clinical outcome and quality of life, with an economic advantage for the healthcare system...
2, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28034293/low-concentrations-of-cationic-pamam-dendrimers-affect-lymphocyte-respiration-in-in-vitro-studies
#14
Magdalena Labieniec-Watala, Marzena Szwed, Joanna Hertel, Ewelina Wisnik
BACKGROUND: The effect of low concentrations of poly(amido)amine dendrimers (G2-G4) on human lymphocytes was studied. Some works revealed that PAMAMs can adversely affect the morphology of blood components and mitochondria functions. In this context, the present report aimed to investigate the in vitro cationic dendrimers' effect on mitochondrial respiration and cell morphology in lymphocytes isolated from human blood. METHODS: To monitor the mitochondria changes, the high-resolution respirometer was used...
December 29, 2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28034292/the-effect-of-pullulan-on-the-growth-and-acidifying-activity-of-selected-stool-microflora-of-human
#15
Anna Chlebowska-Śmigiel, Małgorzata Gniewosz, Marek Kieliszek, Anna Bzducha-Wróbel
BACKGROUND: Pullulan is a microbial polysaccharide of low energy value, which can component of low-calorie foods and in dietary snacks for diabetics. The objective of the study was to determine the effect of pullulan on the growth and fermentation activity of selected human intestinal bacteria. METHODS: Commercial pullulan purchased from Focubase (China) of a molecular weight of 100,000 Da constituted as experimental material. Food grade pullulan 99% purity. Two control media were prepared: the first standard RCM composed of (g/100 ml): 0...
December 29, 2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28017140/molecular-cellular-and-pharmaceutical-aspects-of-filling-biomaterials-during-the-management-of-extraction-sockets
#16
Antonio Barone, Fortunato Alfonsia, Valentina Borgia, Giovanna Iezzi, Adriano Piattelli, Ugo Covani, Paolo Tonelli
After a tooth extraction both hard and soft tissues undergo dimensional changes. The use of a ridge preservation technique at the moment of the tooth extraction could help could help to prevent the volume loss, thus simplifying the subsequent prosthetic and/or implant therapy. Some studies were conducted in order to examine the biomaterials and the surgical technique used for ridge preservation procedures. Clinical, histological, volumetric and molecular outcomes were registered and analysed in different studies, in order to comprehend the biological events and the consequences of a socket preservation procedure and to allow the clinician to make the correct choice...
December 23, 2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28003002/impact-of-different-implant-surfaces-topographies-on-peri-implant-tissues-an-update-of-current-available-data-on-dental-implants-retrieved-from-human-jaws
#17
Jamil Awad Shibli, Jefferson T Pires, Adriano Piattelli, Giovanna Iezzi, Carlo Mangano, Francesco Mangano, Sergio Luiz Scombati de Souza, Sergio A Gehrke, Hom-Lay Wang, David Dohan Ehrenfest
The high success range obtained with the implant-supported restorations has improved its applicability on routine of the daily clinical practice. This elevated percentage of success is related to the previous pre-clinical data obtained from animal and in vitro studies that evaluated the impact of implant surface topographies on bone tissue. However, the histologic evaluation of human bone tissue is scarce. Therefore, the aim of this review is to depict an actual panorama of the data available on bone-to-implant contact (BIC) of retrieved implants from human jaws...
December 21, 2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28003001/molecular-cellular-and-pharmaceutical-aspects-of-bone-grafting-materials-and-membranes-during-maxillary-sinus-lift-procedures-part-1-a-general-overview
#18
Adriano Piatelli, Giovanna Iezzi, Alessandra Giuliani, Carlo Mangano, Licia Manzon, Marco Degidi, Flavia Iaculli, Antonio Scarano, Antonella Filippone, Vittoria Perrotti
Sinus augmentation procedure has been demonstrated to be a highly predictable treatment in posterior maxilla atrophy. All the surgical interventions in the maxillary region require deep knowledge of anatomy and possible anatomical variations. In this article pre-operative and post- operative assessments of sinus cavity as well as novel approaches to deepen our knowledge of the behavior of bone substitute materials are described. The awareness of the patient's morphologic conditions enables exact planning of invasive surgery and aids to avoid complications...
December 21, 2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/27981899/high-hydrostatic-pressure-assisted-enzymatic-treatment-improves-antioxidant-and-anti-inflammatory-properties-of-phosvitin
#19
Heejoo Yoo, Fatemeh Bamdad, Naiyana Gujral, Joo-Won Suh, Hoon Sunwoo
BACKGROUND: Phosvitin (PV) is a highly-phosphorylated metal-binding protein in egg yolk. Phosphoserine clusters make PV resistant to enzymatic digestion, which might be nutritionally undesirable. OBJECTIVE: This study was designed to determine the effects of high hydrostatic pressure and enzymatic hydrolysis (HHP-EH) on the antioxidant and anti-inflammatory properties of PV hydrolysates (PVHs). METHODS: PV was hydrolyzed by alcalase, elastase, savinase, thermolysin, and trypsin at 0...
December 16, 2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/27978809/antibacterial-combination-of-oleoresin-from-copaifera-multijuga-hayne-and-biogenic-silver-nanoparticles-towards-streptococcus-agalactiae
#20
E S Otaguiri, Aeb Morguette, R P Biasi-Garbin, A T Morey, Cac Lancheros, D Kian, A G Oliveira, G Kerbauy, Mre Perugini, N Durán, C V Nakamura, V F Veiga Junior, G Nakazato, P Pinge-Filho, L M Yamauchi, S F Yamada-Ogatta
BACKGROUND: Streptococcus agalactiae (group B Streptococcus - GBS) remains a leading cause of neonatal infections and an important cause of invasive infections in adults with underlying conditions. METHODS: This study evaluated for the first time the effect of an oleoresin collected from Copaifera multijuga Hayne (copaiba oil) alone or in combination with silver nanoparticles produced by green synthesis using Fusarium oxysporum (AgNPbio) against planktonic and sessile cells of GBS isolated from colonized women...
December 13, 2016: Current Pharmaceutical Biotechnology
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