journal
MENU ▼
Read by QxMD icon Read
search

AAPS PharmSciTech

journal
https://www.readbyqxmd.com/read/29450829/artificial-lipid-membrane-permeability-method-for-predicting-intestinal-drug-transport-probing-the-determining-step-in-the-oral-absorption-of-sulfadiazine-influence-of-the-formation-of-binary-and-ternary-complexes-with-cyclodextrins
#1
Alicia Delrivo, Carolina Aloisio, Marcela R Longhi, Gladys Granero
We propose an in vitro permeability assay by using a modified lipid membrane to predict the in vivo intestinal passive permeability of drugs. Two conditions were tested, one with a gradient pH (pH 5.5 donor/pH 7.4 receptor) and the other with an iso-pH 7.4. The predictability of the method was established by correlating the obtained apparent intestinal permeability coefficients (P app ) and the oral dose fraction absorbed in humans (f a ) of 16 drugs with different absorption properties. The P app values correlated well with the absorption rates under the two conditions, and the method showed high predictability and good reproducibility...
February 15, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29450828/the-role-of-excipients-in-the-stability-of-triamcinolone-acetonide-in-ointments
#2
Anton J P van Heugten, Wouter S de Vries, Marian M A Markesteijn, Roland J Pieters, H Vromans
Degradation of triamcinolone acetonide (TCA) in an ointment was investigated. TCA appeared to be concentrated in propylene glycol (PG) which in turn is dispersed in a lanolin-petrolatum mixture. Two predominant degradation products were identified: a 21-aldehyde and a 17-carboxylic acid. The 21-aldehyde is formed after TCA is oxidized by O 2 , a reaction that is catalyzed by trace metals. Logically, the content of trace metals has a profound effect on the degradation rate. It was shown that trace metals are extracted from lanolin and petrolatum by PG, increasing the concentration in PG...
February 15, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29441468/a-novel-approach-for-dry-powder-coating-of-pellets-with-ethylcellulose-part-ii-evaluation-of-caffeine-release
#3
Beatrice Albertini, Cecilia Melegari, Serena Bertoni, Luisa Stella Dolci, Nadia Passerini
The objective of this study was to assess the efficacy and the capability of a novel ethylcellulose-based dry-coating system to obtain prolonged and stable release profiles of caffeine-loaded pellets. Lauric and oleic acids at a suitable proportion were used to plasticize ethylcellulose. The effect of coating level, percentage of drug loading, inert core particle size, and composition of the coating formulation including the anti-sticking agent on the drug release profile were fully investigated. A coating level of 15% w/w was the maximum layered amount which could modify the drug release...
February 13, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29435904/performance-of-the-population-bioequivalence-pbe-statistical-test-using-an-ipac-rs-database-of-delivered-dose-from-metered%C3%A2-dose-inhalers
#4
Beth Morgan, Stephanie Chen, David Christopher, Göran Långström, Christopher Wiggenhorn, Elise Burmeister Getz, Hayden Beresford, Thomas Hoffelder, Daniela Acerbi, Stephen Andrews, Mark Berry, Monisha Dey, Keyur Joshi, Mary McKenry, Marisa Pertile, Helen Strickland, David Wilcox, Svetlana Lyapustina
This article reports performance characteristics of the population bioequivalence (PBE) statistical test recommended by the US Food and Drug Administration (FDA) for orally inhaled products. A PBE Working Group of the International Pharmaceutical Aerosol Consortium on Regulation and Science (IPAC-RS) assembled and considered a database comprising delivered dose measurements from 856 individual batches across 20 metered dose inhaler products submitted by industry. A review of the industry dataset identified variability between batches and a systematic lifestage effect that was not included in the FDA-prescribed model for PBE...
February 12, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29435903/preparation-of-controlled-release-particles-based-on-spherical-porous-silica-used-as-the-drug-carrier-by-the-dry-coating-method
#5
Shohei Nakamura, Shihoko Kondo, Ayaka Mohri, Takatoshi Sakamoto, Hiroshi Yuasa
A controlled-release formulation is a dosage form that could improve a patient's quality of life by reducing the frequency of administration, while ensuring the continued effect of the medicine and reducing the side effects. To prepare these controlled-release particles, a wet coating method in which a drug is coated with a controlled-release material using water or an organic solvent is used, but with this method, the coating process is very time-consuming and requires large amounts of energy for the drying phase...
February 12, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29404955/comparative-study-of-glyceryl-behenate-or-polyoxyethylene-40-stearate-based-lipid-carriers-for-trans-resveratrol-delivery-development-characterization-and-evaluation-of-the-in-vitro-tyrosinase-inhibition
#6
Naiara Fachinetti, Roberta Balansin Rigon, Josimar O Eloy, Mariana Rillo Sato, Karen Cristina Dos Santos, Marlus Chorilli
Trans-resveratrol (RSV) is a natural compound with several properties, such as the ability to inhibit the tyrosinase enzyme, with potential application as a skin-lightning agent and for the treatment of skin disorders associated with hyperpigmentation and melanogenesis. However, the drug faces several drawbacks which altogether limit its therapeutic application. Thus, drug loading into nanocarriers emerge as an alternative to circumvent these problems. Herein, nanostructured lipid carriers (NLCs) have been employed for RSV encapsulation, with comparison of two different lipids, glyceryl behenate (more hydrophobic), and polyoxyethylene 40 (PEG 40) stearate...
February 5, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29396734/formulation-and-characterization-of-fast-dissolving-sublingual-film-of-iloperidone-using-box-behnken-design-for-enhancement-of-oral-bioavailability
#7
Vaishali Londhe, Rucha Shirsat
Iloperidone is a second-generation antipsychotic drug which is used for the treatment of schizophrenia and has very low aqueous solubility and bioavailability. This drug also undergoes first-pass metabolism. The aim of this work is to formulate fast-dissolving sublingual films of iloperidone to improve its bioavailability. Sublingual films were prepared by solvent casting method. Hydroxypropyl methyl cellulose E5, propylene glycol 400, and transcutol HP were optimized using Box-Behnken three-level statistical design on the basis of disintegration time and folding endurance of films...
February 2, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29388027/risk-assessment-integrated-qbd-approach-for-development-of-optimized-bicontinuous-mucoadhesive-limicubes-for-oral-delivery-of-rosuvastatin
#8
Md Noushad Javed, Kanchan Kohli, Saima Amin
Statins are widely prescribed for hyperlipidemia, cancer, and Alzheimer's disease but are facing some inherent challenges such as low solubility and drug loading, higher hepatic metabolism, as well as instability at gastric pH. So, relatively higher circulating dose, required for exerting the therapeutic benefits, leads to dose-mediated severe toxicity. Furthermore, due to low biocompatibility, high toxicity, and other regulatory caveats such as product conformity, reproducibility, and stability of conventional formulations as well as preferentially higher bioabsorption of lipids in their favorable cuboidal geometry, enhancement in in vivo biopharmaceutical performance of Rosuvastatin could be well manifested in Quality by Design (QbD) integrated cuboidal-shaped mucoadhesive microcrystalline delivery systems (Limicubes)...
January 31, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29380282/formulation-and-evaluation-of-organogels-containing-hyaluronan-microparticles-for-topical-delivery-of-caffeine
#9
Erol Eli Simsolo, İpek Eroğlu, Sakine Tuncay Tanrıverdi, Özgen Özer
Cellulite is a dermal disorder including the extracellular matrix, the lymphatic and microcirculatory systems and the adipose tissue. Caffeine is used as the active moiety depending its preventive effect on localization of fat in the cellular structure. Hyaluronic acid (hyaluronan-HA) is a natural constituent of skin that generates formation and poliferation of new cells having a remarkable moisturizing ability. The aim of this study is to formulate HA microparticles loaded with caffeine via spray-drying method...
January 29, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29380281/retraction-note-development-and-in-vitro-in-vivo-characterization-of-chronomodulated-pulsatile-delivery-formulation-of-terbutaline-sulphate-by-box-behnken-statistical-design
#10
Prabhjot Singh Bajwa, Anurag Bhargava, Jaya Sharma, Shailesh Sharma, Abhimanyu Rai Sharma, Binu Sharma
This article has been retracted by the journal because the editors have clear evidence that the scientific findings in this article are unreliable.
January 29, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29352403/micronized-zaleplon-delivery-via-orodispersible-film-and-orodispersible-tablets
#11
Prashanth Manda, Carmen Popescu, Abhishek Juluri, Karthik Janga, Praneeth Rao Kakulamarri, Sushmitha Narishetty, S Narasimha Murthy, Michael A Repka
The following research study focuses on improving the solubility of zaleplon (BCS class II drug) via micronization technique in order to enhance its oral delivery in orodispersible formulations. Zaleplon along with a surfactant solution was micronized by ultrasonication. The micronization process reduced the particle size of the crystalline drug about six-fold from its original size of 155.5 μm. The micronized zalepon dispersion was lyophilized to allow for a change in the state of matter (to a powder). The superior dissolution parameters (Q5, Q30, IDR, MDR, MDT, DE, and RDR) of zaleplon in microcrystalline form over the original crystalline form in in vitro dissolution studies had unraveled that micronization technique is an efficient tool in enhancing drug solubility...
January 19, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29340982/controlled-release-of-the-nimodipine-loaded-self-microemulsion-osmotic-pump-capsules-development-and-characterization
#12
Yaping Huang, Sisi Zhang, Huifen Shen, Jinqing Li, Chongkai Gao
The present study was intended to develop a controlled released osmotic pump capsule based on Nimodipine (NM)-loaded self-microemulsifying drug delivery systems (SMEDDSs) in order to improve the low oral bioavailability of NM. To optimize the NM-loaded SMEDDS composition, the experiments of NM solubility in different oils, the pseudo-ternary phase diagram experiments and the different drug loading experiments were conducted in the preliminary screening studies. Controlled release of NM required an osmotic pump capsule comprising a coated semi-permeable capsule shell, plasticizer, and pore-forming agent...
January 16, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29340981/nanolipid-gel-of-an-antimycotic-drug-for-treating-vulvovaginal-candidiasis-development-and-evaluation
#13
Dnyanesh Takalkar, Namita Desai
This paper focuses on the development and evaluation of mucoadhesive vaginal gel of fluconazole using nanolipid carriers to enhance tissue deposition in treating vulvovaginal candidiasis. Treatment of vulvovaginal candidiasis includes antimycotic agents prescribed for 1 to 7 days or longer, in relapse either orally or topically. The delivery of fluconazole as nanolipid carriers in vaginal gel can be proposed as suitable alternative to the existing conventional formulations to improve the patient acceptability, compliance and localized drug action...
January 16, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29340980/facile-synthesis-of-chitosan-capped-mesoporous-silica-nanoparticles-a-ph-responsive-smart-delivery-platform-for-raloxifene-hydrochloride
#14
Priya V Shah, Sadhana J Rajput
An encapsulation of model drug raloxifene hydrochloride (RAL) inside the chitosan decorated pH responsive mesoporous system has a greater potential for accumulating in the tumor cells. The present study involves synthesis of surface modified mesoporous silica nanoparticles (MSN) with the aim of achieving pH sensitive drug delivery system. A silanol skeleton of MSN has been productively modified to amine intermediate which served as a firm platform to adapt chitosan grafted assembly and systematically evaluated...
January 16, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29340979/effect-of-moisture-content-of-chitin-calcium-silicate-on-rate-of-degradation-of-cefotaxime-sodium
#15
Suhair S Al-Nimry, Khouloud A Alkhamis
Assessment of incompatibilities between active pharmaceutical ingredient and pharmaceutical excipients is an important part of preformulation studies. The objective of the work was to assess the effect of moisture content of chitin calcium silicate of two size ranges (two specific surface areas) on the rate of degradation of cefotaxime sodium. The surface area of the excipient was determined using adsorption method. The effect of moisture content of a given size range on the stability of the drug was determined at 40°C in the solid state...
January 16, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29340978/methotrexate-aspasomes-against-rheumatoid-arthritis-optimized-hydrogel-loaded-liposomal-formulation-with-in-vivo-evaluation-in-wistar-rats
#16
Saikat Ghosh, Biswajit Mukherjee, Shreyasi Chaudhuri, Tanushree Roy, Alankar Mukherjee, Soma Sengupta
Aspasomes of methotrexate with antioxidant, ascorbyl palmitate, were developed and optimized using factorial design by varying parameters such as lipid molar ratio, drug to lipid molar ratio, and type of hydration buffer for transdermal delivery for disease modifying activity in rheumatoid arthritis (RA). Aspasomes were characterized by drug-excipients interaction, particle size analysis, determination of zeta potential, entrapment efficiency, and surface properties. The best formulation was loaded into hydrogel for evaluation of in vitro drug release and tested in vivo against adjuvant induced arthritis model in wistar rats, by assessing various physiological, biochemical, hematological, and histopathological parameters...
January 16, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29340977/new-strategies-for-improving-the-development-and-performance-of-amorphous-solid-dispersions
#17
Abbe Haser, Feng Zhang
The understanding of amorphous solid dispersions has grown significantly in the past decade. This is evident from the number of approved commercial amorphous solid dispersion products. While amorphous formulation is considered an enabling technology, it has become the norm for formulating poorly soluble compounds. Despite this success, improvements can still be made that enable early development formulation decisions, to develop a rationale for selecting a manufacturing process, to overcome degradation and phase separation during processing, to help achieve physical stability during storage, and to optimize dissolution behavior...
January 16, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29327181/correction-to-promising-antibacterial-effects-of-silver-nanoparticle-loaded-tea-tree-oil-nanoemulsion-a-synergistic-combination-against-resistance-threat
#18
Roqya Najafi-Taher, Behnaz Ghaemi, Sharmin Kharrazi, Samira Rasoulikoohi, Amir Amani
With regrets, there is an error in the name of one of the authors which has only been noticed after publication.
January 11, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29318467/theoretical-and-experimental-studies-of-the-controlled-release-of-tetracycline-incorporated-into-bioactive-glasses
#19
Ângela L Andrade, Isabela A Militani, Katia J de Almeida, Jadson C Belchior, Sérgio C Dos Reis, Rosangela M F Costa E Silva, Rosana Z Domingues
Several authors have studied the release profile of drugs incorporated in different devices. However, to the best of our knowledge, although many studies have been done on the release of tetracycline, in these release devices, no study has investigated if the released compound is actually the tetracycline, or, instead, a degraded product. This approach is exploited here. In this work, we analyse the influence of two drying methods on the tetracycline delivery behaviour of synthesised glasses using the sol-gel process...
January 9, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29313262/structural-elucidation-of-poloxamer-237-and-poloxamer-237-praziquantel-solid-dispersions-impact-of-poly-vinylpyrrolidone-over-drug-recrystallization-and-dissolution
#20
Silvina Orlandi, Josefina Priotti, Hermínio P Diogo, Dario Leonardi, Claudio J Salomon, Teresa G Nunes
Praziquantel (PZQ) is the recommended, effective, and safe treatment against all forms of schistosomiasis. Solid dispersions (SDs) in water-soluble polymers have been reported to increase solubility and bioavailability of poorly water-soluble drugs like PZQ, generally due to the amorphous form stabilization. In this work, poloxamer (PLX) 237 and poly(vinylpyrrolidone) (PVP) K30 were evaluated as potential carriers to revert PZQ crystallization. Binary and ternary SDs were prepared by the solvent evaporation method...
January 8, 2018: AAPS PharmSciTech
journal
journal
35107
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"