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Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP

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https://www.readbyqxmd.com/read/29783005/metal-accumulation-and-expression-of-genes-encoding-for-metallothionein-and-copper-transporters-in-a-chronically-exposed-wild-population-of-the-fish-hyphessobrycon-luetkenii
#1
Sandra Isabel Moreno Abril, Patrícia Gomes Costa, Adalto Bianchini
In the present study, metal (As, Cd, Cu, Fe, Mn, Pb and Zn) accumulation and expression of genes involved in metal metabolism (metallothioneins, ATP7A and CTR1) were evaluated in gills and muscle of the fish Hyphessobrycon luetkenii living in the João Dias creek, a site historically (~1870-1996) contaminated with a metal mixture associated with copper mining (Minas do Camaquã, southern Brazil). Fish were collected in a metal impacted site of the João Dias creek and kept in a cage at this site (PP fish) or translocated to a non-metal impacted reach of this creek (PC fish)...
May 18, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29777853/investigation-of-the-potential-endocrine-effect-of-nitrate-in-zebrafish-danio-rerio-and-brown-trout-salmo-trutta
#2
Poul Bjerregaard, Karin Lund Kinnberg, Maria Pedersen Mose, Henrik Holbech
Nitrate has the potential to affect steroid production. Nitrate concentrations in streams in agricultural areas may exceed concentrations showing effects in laboratory studies. The effects of nitrate and/or nitrite on endocrine relevant endpoints were tested in zebrafish and brown trout. Zebrafish were exposed in two experiments to nitrate (8.8 to 89 mg NO3 - /L) and nitrite (3.6 to 19 mg NO2 - /L) during the period of sexual differentiation and sex ratios were determined. Vitellogenin concentrations were determined in the second experiment...
May 16, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29763690/the-citrus-flavonone-hesperetin-attenuates-the-nuclear-translocation-of-aryl-hydrocarbon-receptor
#3
Yan Qin Tan, Leo Clement Chiu-Leung, Shu-Mei Lin, Lai K Leung
The environmental polycyclic aromatic hydrocarbons (PAH) and dioxins are carcinogens and their adverse effects have been largely attributed to the activation of AhR. Hesperetin is a flavonone found abundantly in citrus fruits and has been shown to be a biologically active agent. In the present study, the effect of hesperetin on the nuclear translocation of AhR and the downstream gene expression was investigated in MCF-7 cells. Confocal microscopy indicated that 7, 12-dimethylbenz[α]anthracene (DMBA) or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) -induced nuclear translocation of AhR was deterred by hesperetin treatment...
May 16, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29763692/pharmacological-evidence-that-dapi-inhibits-nhe2-in-fundulus-heteroclitus-acclimated-to-freshwater
#4
Kevin V Brix, Colin J Brauner, Dolph Schluter, Chris M Wood
Ionoregulation in the euryhaline killifish Fundulus heteroclitus has been intensively studied over the last two decades using a variety of techniques. However, there has been limited use of pharmacological inhibitors to identify proteins involved in ion transport for this species. In this study, we used a range of pharmacological inhibitors (EIPA, DAPI, ethoxzolamide, bumetanide, bafilomycin, phenamil, hydrochlorothiazide) to investigate the proteins involved in Na+ transport in freshwater (1 mM Na+ ) acclimated F...
May 12, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29763691/insights-on-the-age-dependent-neurodegeneration-induced-by-monocrotophos-an-organophosphorous-insecticide-in-caenorhabditis-elegans-fed-high-glucose-evidence-in-wild-and-transgenic-strains
#5
Chinnu Salim, Nidheesh Thadathil, M Muralidhara, P S Rajini
The higher susceptibility of high glucose fed C. elegans to Monocrotophos (MCP, an organophosphorus insecticide) - induced dopaminergic (DA) neuronal degeneration was recently demonstrated. Employing this acute exposure model, the impact of MCP on DA degeneration among worms of two age groups (8 and 13 d old) fed control (CO) and high glucose (GF) diet with specific focus on phenotypic alterations, oxidative impairments and associated molecular perturbations employing both wild (N2) and transgenic strains(BZ555 and NL5901) was investigated...
May 12, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29758383/does-size-matter-venom-proteomic-and-functional-comparison-between-night-adder-species-viperidae-causus-with-short-and-long-venom-glands
#6
Francisco C P Coimbra, James Dobson, Christina N Zdenek, Bianca Op den Brouw, Brett Hamilton, Jordan Debono, Paul Masci, Nathaniel Frank, Lilin Ge, Hang Fai Kwok, Bryan G Fry
Night adders (Causus species within the Viperidae family) are amphibian specialists and a common source of snakebite in Africa. Some species are unique in that they have the longest venom glands of any viper, extending approximately 10% of the body length. Despite their potential medical importance and evolutionary novelty, their venom has received almost no research attention. In this study, venoms from a short-glanded species (C. lichtensteinii) and from a long-glanded species (C. rhombeatus) were compared using a series of proteomic and bioactivity testing techniques to investigate and compare the toxin composition and functioning of the venoms of these two species...
May 11, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29758382/effects-of-exposure-to-bpf-on-development-and-sexual-differentiation-during-early-life-stages-of-zebrafish-danio-rerio
#7
Qian Yang, Xianhai Yang, Jining Liu, Yingwen Chen, Shubao Shen
Bisphenol F (BPF) has become a predominant bisphenol contaminant in recent years. It has significant estrogenic properties in both in vivo and in vitro studies. We have previously studied the disrupting mechanisms of BPF on the hypothalamic-pituitary-gonadal axis of adult zebrafish. However, the effects of BPF exposure on development and sexual differentiation of zebrafish embryos/larvae remain unclear. To determine the effects of BPF on the critical stage of sex differentiation in zebrafish, zebrafish embryos/larvae were exposed to 1, 10, 100, and 1000 μg/L BPF from fertilization to 60 days post-fertilization (dpf)...
May 11, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29746996/plasma-biomarkers-in-juvenile-marine-fish-provide-evidence-for-endocrine-modulation-potential-of-organotin-compounds
#8
Byung Hwa Min, Bo-Mi Kim, Moonkoo Kim, Jung-Hoon Kang, Jee-Hyun Jung, Jae-Sung Rhee
Organotin compounds, such as tributyltin (TBT) and triphenyltin (TPT), have been widely used to control marine fouling. Here, we show that organotin stimulation reduces the hormone levels in the plasma of two economically important aquaculture fish. Blood plasma samples were collected from juvenile red seabream and black rockfish exposed to environmentally realistic concentrations of TBT and TPT for 14 days. The levels of two plasma biomarkers, namely the yolk protein precursor vitellogenin (VTG) and the sex steroid 17β-estradiol (E2), were measured to determine the endocrine disrupting potential of the organotin compounds...
May 7, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29729480/the-anti-androgenic-effect-of-chronic-exposure-to-semicarbazide-on-male-japanese-flounder-paralichthys-olivaceus-and-its-potential-mechanisms
#9
Zonghao Yue, Miao Yu, Xiaona Zhang, Jun Wang, Shaoguo Ru
Semicarbazide (SMC), a new marine pollutant, has anti-estrogenic effects on female Japanese flounder (Paralichthys olivaceus). However, whether SMC also affects the reproductive endocrine system of male marine organisms is currently unclear. In this study, Japanese flounder embryos were exposed to 1, 10, and 100 μg/L SMC for 130 days. Plasma testosterone (T) and 17β-estradiol (E2 ) concentrations were significantly decreased in male flounders after SMC exposure. The expression of genes involved in T and E2 synthesis, including steroidogenic acute regulatory protein, cytochrome P450 11A1, 17α-hydroxylase, 17β-hydroxysteroid dehydrogenase and cytochrome P450 19A, was down-regulated in the gonads, which may explain the decrease in plasma sex hormones levels...
May 2, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29698686/structural-and-functional-analysis-of-two-novel-somatostatin-receptors-identified-from-topmouth-culter-erythroculter-ilishaeformis
#10
Haiyan Dong, Yunhai Wei, Chao Xie, Xiaoxuan Zhu, Chao Sun, Qianwen Fu, Lei Pan, Mengting Wu, Yinghan Guo, Jianwei Sun, Hong Shen, Jinyun Ye
In the present study, we cloned and characterized two somatostatin (SS) receptors (SSTRs) from topmouth culter (Erythroculter ilishaeformis) designated as EISSTR6 and EISSTR7. Analysis of EISSTR6 and EISSTR7 signature motifs, 3D structures, and homology with the known members of the SSTR family indicated that the novel receptors had high similarity to the SSTRs of other vertebrates. EISSTR6 and EISSTR7 mRNA expression was detected in 17 topmouth culter tissues, and the highest level was observed in the pituitary...
April 23, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29698685/effect-of-hemin-baicalein-and-heme-oxygenase-1-ho-1-enzyme-activity-inhibitors-on-cd-induced-accumulation-of-ho-1-hsps-and-aggresome-like-structures-in-xenopus-kidney-epithelial-cells
#11
James H Campbell, John J Heikkila
Cadmium is a highly toxic environmental pollutant that can cause many adverse effects including cancer, neurological disease and kidney damage. Aquatic amphibians are particularly susceptible to this toxicant as it was shown to cause developmental abnormalities and genotoxic effects. In mammalian cells, the accumulation of heme oxygenase-1 (HO-1), which catalyzes the breakdown of heme into CO, free iron and biliverdin, was reported to protect cells against potentially lethal concentrations of CdCl2 . In the present study, CdCl2 treatment of A6 kidney epithelial cells, derived from the frog, Xenopus laevis, induced the accumulation of HO-1, heat shock protein 70 (HSP70) and HSP30 as well as an increase in the production of aggregated protein and aggresome-like structures...
April 23, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29654925/effects-of-bisphenol-a-bpa-on-brain-specific-expression-of-cyp19a1b-gene-in-swim-up-fry-of-labeo-rohita
#12
Shreyasi Gupta, Payel Guha, Suravi Majumder, Puja Pal, Kousik Sen, Piyali Sarkar, Arindam Chakraborty, Ashis Kumar Panigrahi, Dilip Mukherjee
Estrogen regulates numerous developmental and physiological processes and effects are mediated mainly by estrogenic receptors (ERs), which function as ligand-regulated transcription factor. ERs can be activated by many different types endocrine disrupting chemicals (EDCs) and interfere with behaviour and reproductive potential of living organism. Estrogenic regulation of membrane associated G protein-coupled estrogen receptor, GPER activity has also been reported. Bisphenol A (BPA), a ubiquitous endocrine disruptor is present in many household products, has been linked to many adverse effect on sexual development and reproductive potential of wild life species...
April 11, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29625345/toward-an-adverse-outcome-pathway-for-impaired-growth-mitochondrial-dysfunction-impairs-growth-in-early-life-stages-of-the-fathead-minnow-pimephales-promelas
#13
Derek G Bolser, David A Dreier, Erchao Li, Kevin J Kroll, Christopher J Martyniuk, Nancy D Denslow
Chemical contaminants present in the environment can affect mitochondrial bioenergetics in aquatic organisms and can have substantial effects on individual fitness. As early life stages of fish are particularly vulnerable to environmental contaminants, they are ideal models for examining the relationship between impaired mitochondrial bioenergetics (ATP-dependent respiration, basal oxidative respiration) and apical endpoints such as growth. Here, early life stages of the fathead minnow (Pimephales promelas), an ecologically relevant North American species, were used to investigate the relationship between mitochondrial bioenergetics and growth following perturbation with model mitochondrial toxicants 2,4-dinitrophenol and octylamine...
April 3, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29625344/response-of-antioxidant-enzymes-to-cd-and-pb-exposure-in-water-flea-daphnia-magna-differential-metal-and-age-specific-patterns
#14
Haeyeon Kim, Ji-Soo Kim, Pyoung-Joong Kim, Eun-Ji Won, Young-Mi Lee
To investigate oxidative stress responses to cadmium and lead, the freshwater water flea Daphnia magna was exposed to Cd and Pb for 48 h. Following treatment with sub-lethal concentrations, intracellular reactive oxygen species (ROS) levels, as well as modulation of multiple biomarker, such as superoxide dismutase (SOD) activity, glutathione (GSH) contents, glutathione S-transferase (GST) activity, antioxidant enzyme - coding genes (three GST isoforms, glutaredoxin [GRx], glutathione peroxidase [GPx], and thioredoxin [TRx]), and stress-response proteins (heat shock protein 70 [Hsp70] and Hsp90) were examined...
April 3, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29604435/in-vitro-effects-of-crotalus-atrox-snake-venom-on-chick-and-mouse-neuromuscular-preparations
#15
Raphael Schezaro-Ramos, Saulo L Da Silva, Beatriz B Pereira, Ananda T Santa Fé Miguel, Bruno Mendes, Noroska G S Mogollón, Stephen Hyslop, Victor C Carregari, José R Almeida
The neuromuscular effect of rattlesnake venoms is not a major clinical manifestation shared between rattlesnakes native to the Americas, which showed two different venom phenotypes. Taking into account this dichotomy, nerve muscle preparations from mouse and chicks were used to investigate the ability of Crotalus atrox venom to induce in vitro neurotoxicity and myotoxicity. Unlike crotalic venoms of South America, low doses of C. atrox venom did not result in significant effects on mouse neuromuscular preparations...
March 28, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29574035/effects-of-short-term-lead-exposure-on-gut-microbiota-and-hepatic-metabolism-in-adult-zebrafish
#16
Jizhou Xia, Liang Lu, Cuiyuan Jin, Siyu Wang, Jicong Zhou, Yingchun Ni, Zhengwei Fu, Yuanxiang Jin
Lead (Pb) is one of the most prevalent toxic, nonessential heavy metals that has been associated with a wide range of toxic effects in humans and environmental animals. Here, effects of short time exposure to 10 and 30 μg/L Pb on gut microbiota and hepatic metabolism were analyzed in adult male zebrafish. We observed that both 10 and 30 μg/L Pb increased the volume of mucus in the gut. At phylum level, the abundance of α-Proteobacteria decreased significantly and the abundance of Firmicutes increased significantly in the gut when treated with 30 μg/L Pb for 7 days...
March 22, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29567411/abnormal-nuclear-morphology-is-independent-of-longevity-in-a-zmpste24-deficient-fish-model-of-hutchinson-gilford-progeria-syndrome-hgps
#17
Yasuhiro Tonoyama, Minori Shinya, Atsushi Toyoda, Takeshi Kitano, Atsunori Oga, Toshiyuki Nishimaki, Takafumi Katsumura, Hiroki Oota, Miles T Wan, Bill W P Yip, Mok O L Helen, Shinichi Chisada, Tomonori Deguchi, Doris W T Au, Kiyoshi Naruse, Yasuhiro Kamei, Yoshihito Taniguchi
Lamin is an intermediate protein underlying the nuclear envelope and it plays a key role in maintaining the integrity of the nucleus. A defect in the processing of its precursor by a metalloprotease, ZMPSTE24, results in the accumulation of farnesylated prelamin in the nucleus and causes various diseases, including Hutchinson-Gilford progeria syndrome (HGPS). However, the role of lamin processing is unclear in fish species. Here, we generated zmpste24-deficient medaka and evaluated their phenotype. Unlike humans and mice, homozygous mutants did not show growth defects or lifespan shortening, despite lamin precursor accumulation...
March 19, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29563044/influences-of-acephate-and-mixtures-with-other-commonly-used-pesticides-on-honey-bee-apis-mellifera-survival-and-detoxification-enzyme-activities
#18
Jianxiu Yao, Yu Cheng Zhu, John Adamczyk, Randall Luttrell
Acephate (organophosphate) is frequently used to control piercing/sucking insects in field crops in southern United States, which may pose a risk to honey bees. In this study, toxicity of acephate (formulation Bracket® 97) was examined in honey bees through feeding treatments with sublethal (pollen residue level: 0.168 mg/L) and median-lethal (LC50 : 6.97 mg/L) concentrations. Results indicated that adult bees treated with acephate at residue concentration did not show significant increase in mortality, but esterase activity was significantly suppressed...
March 18, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29555404/effects-of-dietary-crude-oil-exposure-on-molecular-and-physiological-parameters-related-to-lipid-homeostasis-in-polar-cod-boreogadus-saida
#19
Ireen Vieweg, Eider Bilbao, James P Meador, Ibon Cancio, Morgan Lizabeth Bender, Miren P Cajaraville, Jasmine Nahrgang
Polar cod is an abundant Arctic key species, inhabiting an ecosystem that is subjected to rapid climate change and increased petroleum related activities. Few studies have investigated biological effects of crude oil on lipid metabolism in this species, despite lipids being a crucial compound for Arctic species to adapt to the high seasonality in food abundance in their habitat. This study examines the effects of dietary crude oil exposure on transcription levels of genes related to lipid metabolism (peroxisome proliferator-activated receptors [ppar-α, ppar-γ], retinoic X receptor [rxr-β], palmitoyl-CoA oxidase [aox1], cytochrome P4507A1 [cyp7α1]), reproduction (vitellogenin [vtg-β], gonad aromatase [cyp19a1]) and biotransformation (cytochrome P4501A1 [cyp1a1], aryl hydrocarbon receptor [ahr2])...
March 16, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29551388/oxidative-effects-of-the-acute-exposure-to-a-pesticide-mixture-of-cypermethrin-and-chlorpyrifos-on-carp-and-zebrafish-a-comparative-study
#20
Mauro E M Nunes, Talise E Müller, Camila Murussi, Aline M B Amaral, Jeane L C Gomes, Aline T Marins, Jossiele Leitemperger, Cintia C R Rodrigues, Tiago L Fiuza, Maiara D Costa, Eduardo S Severo, Denis B Rosemberg, Vania L Loro
The use of commercial pesticides combinations increases the risk of intoxication in non-target aquatic organisms. Here, we investigate the potential of a commercial pesticide formulation containing (CYP) plus chlopyrifos (CPF) to induce oxidative damage on two fish species (common carp and zebrafish). Carp and zebrafish were exposed for 96 h under laboratory conditions. Fish were divided in three different groups: CTL, 0.3 μg L-1 or 0.6 μg L-1 of CYP and 0.5 or 1 μg L-1 of CPF in commercial formulation...
March 15, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
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