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Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP

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https://www.readbyqxmd.com/read/29129589/behavior-of-detoxifying-enzymes-of-aedes-aegypti-exposed-to-girgensohnine-alkaloid-analog-and-cymbopogon-flexuosus-essential-oil
#1
Aurora L Carreño Otero, Angela Maria Palacio-Cortés, Mario Antonio Navarro-Silva, Vladimir V Kouznetsov, Jonny E Duque L
Because mosquito control depend on the use of commercial insecticides and resistance has been described in some of them, there is a need to explore new molecules no resistant. In vivo effects of girgensohnine analog 2-(3,4-dimethoxyphenyl)-2-(piperidin-1-yl)acetonitrile DPPA and Cymbopogon flexuosus essential oil CFEO, on the detoxifying enzymes acetylcholinesterase (AChE), glutathione-S-transferase (GST), nonspecific esterases (α- and β-), mixed function oxidases (MFO) and p-NPA esterases were evaluated on a Rockefeller (Rock) and wild Aedes aegypti population from Santander, Colombia (WSant)...
November 10, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29128602/developmental-effects-of-the-protein-kinase-inhibitor-kenpaullone-on-the-sea-urchin-embryo
#2
Letizia Anello, Vincenzo Cavalieri, Maria Di Bernardo
The selection and validation of bioactive compounds require multiple approaches, including in-depth analyses of their biological activity in a whole-animal context. We exploited the sea urchin embryo in a rapid, medium-scale range screening to test the effects of the small synthetic kinase inhibitor kenpaullone. We show that sea urchin embryos specifically respond to this molecule depending on both dose and timing of administration. Phenotypic effects of kenpaullone are not immediately visible, since this molecule affects neither the fertilization nor the spatial arrangement of blastomeres at early developmental stages...
November 10, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29104176/chemically-dispersed-oil-is-cytotoxic-and-genotoxic-to-sperm-whale-skin-cells
#3
Catherine F Wise, James T F Wise, Sandra S Wise, John Pierce Wise
Two major oil crises in United States history, the 1989 Exxon-Valdez oil spill in Alaska and the 2010 Deepwater Horizon Oil Rig explosion in the Gulf of Mexico, drew attention to the need for toxicological experiments on oil and chemically dispersed oil. We are still learning the effects these spills had on wildlife. However, little data is known about the toxicity of these substances in marine mammals. The objective of this study is to determine the toxicity of Alaskan oil, as well as chemically dispersed oil...
November 8, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29122702/estrogenic-effects-following-larval-exposure-to-the-putative-anti-estrogen-fulvestrant-in-the-fathead-minnow-pimephales-promelas
#4
Jonathan M Ali, Michael T Palandri, Alex T Kallenbach, Edwin Chavez, Jonathan Ramirez, Sathaporn Onanong, Daniel D Snow, Alan S Kolok
The objective of the present study was to investigate the consequences of early-life exposure to fulvestrant on estrogenic gene expression in fathead minnow larvae. To address this objective, fathead minnow larvae were exposed to fulvestrant (ICI 182,780) during the window of sexual differentiation between 0 to 30 days post-hatch (dph). The four treatment groups in this study included: filtered water controls (never exposed), solvent controls (ethanol 0.01%), and nominally low (0.10μg/L) and high (10.0μg/L) doses of fulvestrant...
November 6, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29100953/dietary-methionine-restriction-effects-on-glucose-tolerance-lipid-content-and-micro-rna-composition-in-the-muscle-of-rainbow-trout
#5
M N Latimer, B M Cleveland, P R Biga
Lean muscle mass plays an important role in overall health, as altered skeletal muscle metabolism can impact both the incidence and prevention of conditions related to metabolic health. Intriguingly, dietary methionine restriction (MR) has been shown to ameliorate this phenotype over time potentially through mechanisms related to changes in myogenic precursor cell (MPC) differentiation status. Recently the role of micro-RNAs (miRs) in regulating the expression of muscle specific transcription factors myoD and myogenin as well as signaling molecules involved in skeletal muscle differentiation has been reported in vitro...
October 31, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29100952/effect-of-isothiocyanates-bitc-and-peitc-on-stress-protein-accumulation-protein-aggregation-and-aggresome-like-structure-formation-in-xenopus-a6-kidney-epithelial-cells
#6
Imran Khamis, John J Heikkila
Numerous studies have elucidated the health benefits of organosulfur compounds, known as isothiocyanates (ITCs), derived from cruciferous vegetables. As electrophiles, ITCs have the ability to directly bind and modify thiol-containing compounds such as glutathione and cellular protein, including tubulin. While the biochemical effects of ITCs have been well characterized, less information is available regarding their effects on the accumulation of stress-inducible heme oxygenase-1 (HO-1), heat shock proteins (HSPs) and the possible formation of aggregated protein due to thiol modification...
October 31, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29100894/corrigendum-to-glyphosate-based-herbicide-exposure-causes-antioxidant-defence-responses-in-the-fruit-fly-drosophila-melanogaster-previously-published-at-cbpc-comp-biochem-physiol-c-185-186-2016-94-101
#7
Lais Mattos de Aguiar, Fernanda Hernandes Figueira, Marco Silva Gottschalk, Carlos Eduardo da Rosa
No abstract text is available yet for this article.
October 31, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29107037/transcriptional-correlates-of-proximal-distal-identify-and-regeneration-timing-in-axolotl-limbs
#8
S Randal Voss, David Murrugarra, Tyler B Jensen, James R Monaghan
Cells within salamander limbs retain memories that inform the correct replacement of amputated tissues at different positions along the length of the arm, with proximal and amputations completing regeneration at similar times. We investigated the possibility that positional memory is associated with variation in transcript abundances along the proximal-distal limb axis. Transcripts were deeply sampled from Ambystoma mexicanum limbs at the time they were administered fore arm vs upper arm amputations, and at 20 post-amputation time points...
October 26, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29074260/rattling-the-border-wall-pathophysiological-implications-of-functional-and-proteomic-venom-variation-between-mexican-and-us-subspecies-of-the-desert-rattlesnake-crotalus-scutulatus
#9
James Dobson, Daryl Yang, Bianca Op den Brouw, Chip Cochran, Tam Huynh, Sanjaya Kurrupu, Elda E Sánchez, Daniel J Massey, Kate Baumann, Timothy N W Jackson, Amanda Nouwens, Peter Josh, Edgar Neri-Castro, Alejandro Alagón, Wayne C Hodgson, Bryan G Fry
While some US populations of the Mohave rattlesnake (Crotalus scutulatus scutulatus) are infamous for being potently neurotoxic, the Mexican subspecies C. s. salvini (Huamantlan rattlesnake) has been largely unstudied beyond crude lethality testing upon mice. In this study we show that at least some populations of this wide-ranging snake are as potently neurotoxic as its northern cousin. Testing of the Mexican antivenom Antivipmyn showed a complete lack of neutralisation for the neurotoxic effects of C. s. salvini venom, while the neurotoxic effects of the US subspecies C...
October 23, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29054583/dietary-resveratrol-increases-mid-life-fecundity-of-female-nothobranchius-guentheri
#10
Youngjoo Lee, Andrew C Drake, Nicholas O Thomas, Lindsey G Ferguson, Patrick E Chappell, Kate Petersen Shay
The decline of female reproductive function is an early phenotype of aging in humans, occurring only midway through the lifespan. Yet the number of women delaying pregnancy continues to rise in industrialized societies due to personal or socioeconomic circumstances, often resulting in subfertility or difficulty conceiving. There are few defined mechanisms associated with this etiology, and equally few effective therapies. To combat this problem, we used a novel emerging model, Nothobranchius guentheri, that recapitulates the age-associated spectrum of changes that adversely affect human fertility...
October 17, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29017858/the-transcriptional-response-of-skin-to-fluorescent-light-exposure-in-viviparous-xiphophorus-and-oviparous-danio-oryzias-fishes
#11
Mikki Boswell, William Boswell, Yuan Lu, Markita Savage, Zachary Mazurek, Jordan Chang, Jeanot Muster, Ronald Walter
Differences in light sources are common in animal facilities and potentially can impact experimental results. Here, the potential impact of lighting differences on skin transcriptomes has been tested in three aquatic animal models commonly utilized in biomedical research, (Xiphophorus maculatus (platyfish), Oryzias latipes (medaka) and Danio rerio (zebrafish). Analysis of replicate comparative RNASeq data showed the transcriptional response to commonly utilized 4100K or "cool white" fluorescent light (FL) is much greater in platyfish and medaka than in zebrafish...
October 7, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28974407/controversial-use-of-vitellogenin-as-a-biomarker-of-endocrine-disruption-in-crustaceans-new-adverse-pieces-of-evidence-in-the-copepod-eurytemora-affinis
#12
Céline Boulangé-Lecomte, Benoit Xuereb, Gauthier Trémolet, Aurélie Duflot, Nathalie Giusti, Stéphanie Olivier, Elena Legrand, Joëlle Forget-Leray
In recent years, the interest in the use of vitellogenin (VTG) as a biomarker of endocrine disruption in fish has led to VTG being considered as a potential tool in invertebrates. Among aquatic invertebrate models in ecotoxicology, the copepods are considered as reference species in marine, estuarine and freshwater ecosystems. In this context, we identified a VTG cDNA in Eurytemora affinis. The Ea-VTG2 cDNA is 5416bp in length with an open reading frame (ORF) of 5310bp that encodes a putative protein of 1769 amino acids residues...
September 30, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28965927/fluorescent-light-exposure-incites-acute-and-prolonged-immune-responses-in-zebrafish-danio-rerio-skin
#13
Trevor J Gonzalez, Yuan Lu, Mikki Boswell, William Boswell, Geraldo Medrano, Sean Walter, Samuel Ellis, Markita Savage, Zoltan M Varga, Christian Lawrence, George Sanders, Ronald B Walter
Artificial light produces an emission spectrum that is considerably different than the solar spectrum. Artificial light has been shown to affect various behavior and physiological processes in vertebrates. However, there exists a paucity of data regarding the molecular genetic effects of artificial light exposure. Previous studies showed that one of the commonly used fluorescent light source (FL; 4100K or "cool white") can affect signaling pathways related to maintenance of circadian rhythm, cell cycle progression, chromosome segregation, and DNA repair/recombination in the skin of male Xiphophorus maculatus...
September 29, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28965926/exposure-to-4100k-fluorescent-light-elicits-sex-specific-transcriptional-responses-in-xiphophorus-maculatus-skin
#14
William T Boswell, Mikki Boswell, Dylan J Walter, Kaela L Navarro, Jordan Chang, Yuan Lu, Markita G Savage, Jianjun Shen, Ronald B Walter
It has been reported that exposure to artificial light may affect oxygen intake, heart rate, absorption of vitamins and minerals, and behavioral responses in humans. We have reported specific gene expression responses in the skin of Xiphophorus fish after exposure to ultraviolet light (UV), as well as, both broad spectrum and narrow waveband visible light. In regard to fluorescent light (FL), we have shown that male X. maculatus exposed to 4100K FL (i.e. "cool white") rapidly suppress transcription of many genes involved with DNA replication and repair, chromosomal segregation, and cell cycle progression in skin...
September 29, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28943456/permethrin-pesticide-induces-nurr1-up-regulation-in-dopaminergic-cell-line-is-the-pro-oxidant-effect-involved-in-toxicant-neuronal-damage
#15
Laura Bordoni, Donatella Fedeli, Cinzia Nasuti, Melania Capitani, Dennis Fiorini, Rosita Gabbianelli
The mechanisms associated to the development of neurodegeneration due to pesticide exposure are not clear yet. In this study we evaluated how permethrin pesticide (PERM) can influence the Nurr1 gene and protein expression, and if a pro-oxidant activity of the pesticide contributes to up-regulation of Nurr1 in a dopaminergic cell line. Incubation of PC12 cells with 1μM PERM for 72h, leads to over expression of Nurr1 gene. This effect occurs with both corn oil and extra virgin olive oil (EVO) used to solubilize the toxicant...
September 22, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28943455/assaying-uptake-of-endocrine-disruptor-compounds-in-zebrafish-embryos-and-larvae
#16
J Paige Souder, Daniel A Gorelick
To study the effects of environmental endocrine disruptor compounds (EDCs) on aquatic animals, embryos and larvae are typically incubated in water containing defined concentrations of EDCs. However, the amount of EDC uptake into the animal is often difficult to determine. Using radiolabeled estradiol ([(3)H]E2), we previously developed a rapid, straightforward assay to measure estradiol uptake from water into zebrafish embryos and larvae. Here, we extend this approach to measure the uptake of two additional EDCs, bisphenol A (BPA) and ethinyl estradiol (EE2)...
September 21, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28939507/toxicological-profile-and-acetylcholinesterase-inhibitory-potential-of-palicourea-deflexa-a-source-of-%C3%AE-carboline-alkaloids
#17
Pablo Ricardo Bertelli, Renata Biegelmeyer, Eduardo Pacheco Rico, Luiz Carlos Klein-Junior, Natally S B Toson, Luciane Minetto, Sergio A L Bordignon, André L Gasper, Sidnei Moura, Diogo L de Oliveira, Amélia T Henriques
Palicourea genus is chemically and taxonomically close to Psychotria genus, a well-known source of neuroactive alkaloids. It has been previously reported the pharmacological potential of these alkaloids in some targets related to the neurodegenerative process. In this context, this study was carried out in order to evaluate the toxic effects and acetylcholinesterase (AChE) inhibitory potential of Palicourea deflexa fraction of total alkaloids (FTA). P. deflexa FTA was analyzed by means of HPLC-DAD and HRMS-ESI...
September 20, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28939506/impact-of-teflubenzuron-on-the-rockpool-shrimp-palaemon-elegans
#18
Pål A Olsvik, Bjørn T Lunestad, Ann-Lisbeth Agnalt, Ole B Samuelsen
Concerns have been raised over the environmental impacts of antiparasitic drugs used to delouse farmed salmon. Released into the marine environment, some of these drugs can have negative impact on non-targeted crustaceans in the vicinity of farming facilities. In this study, we examined the molecular effect of the insecticide teflubenzuron on a shrimp species inhabiting the littoral zone, the rockpool shrimp (Palaemon elegans). Rockpool shrimp was exposed for 98days to a dose representing 2% of a regular teflubenzuron medication applied to Atlantic salmon...
September 20, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28939505/impact-of-waterborne-and-trophic-mercury-exposures-on-cardiac-function-of-two-ecologically-distinct-neotropical-freshwater-fish-brycon-amazonicus-and-hoplias-malabaricus
#19
Diana A Monteiro, Edwin W Taylor, Francisco T Rantin, Ana L Kalinin
Metal pollutants have been considered one of the main factors underlying the depletion of biodiversity in natural populations unbalancing aquatic environments. The aim of this study was to evaluate the effects of exposure to inorganic Hg on myocardial contractility and the electrocardiogram (ECG) of two ecologically distinct Neotropical fish species, namely: matrinxã (Brycon amazonicus) and trahira (Hoplias malabaricus). Matrinxãs were exposed to a sublethal concentration of 0.1mgL(-1) of Hg in water for 96h...
September 20, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29111472/assessment-of-8-hydroxy-2-deoxyguanosine-activity-gene-expression-and-antioxidant-enzyme-activity-on-rainbow-trout-oncorhynchus-mykiss-tissues-exposed-to-biopesticide
#20
Gonca Alak, Arzu Ucar, Veysel Parlak, Aslı Çilingir Yeltekin, Ismail Hakkı Taş, Doğukan Ölmez, Esat Mahmut Kocaman, Mustafa Yılgın, Muhammed Atamanalp, Telat Yanık
The goal of this study was to determinate toxicity mechanism of biopesticide with antioxidant enzymes parameters such as superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) and malondialdehyde (MDA) levels, oxidative DNA damage (8-hydroxy-2-deoxyguanosine (8-OHdG)), transcriptional changes of heat shock protein 70 (HSP70), and cytochromes P4501A (CYP1A), sod, cat, and gpx in liver and gill tissues of Oncorhynchus mykiss. For this aim, plant-based (natural pesticides, azadirachtin (AZA)) and synthetic pesticides (deltamethrin (DLM)) were exposed on the fish at different concentrations (0...
December 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
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