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Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP

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https://www.readbyqxmd.com/read/28931493/homarus-gammarus-crustacea-decapoda-larvae-under-an-ocean-acidification-scenario-responses-across-different-levels-of-biological-organization
#1
Lénia D Rato, Sara C Novais, Marco F L Lemos, Luís M F Alves, Sérgio M Leandro
The present study evaluated the effects of exposure to different target pCO2 levels: control (C: 370μatm, pH = 8.15) and ocean acidification (OA: 710μatm, pH=7.85) on development and biochemical responses related with oxidative stress and energy metabolism during the crustacean Homarus gammarus (L.) larval development, integrating different levels of biological organization. After hatching in the laboratory, larvae from the same female brood were exposed to the described conditions from hatching until reaching Stage III (last larval stage - 11 days)...
September 17, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28923244/cardio-respiratory-function-during-exercise-in-the-cobia-rachycentron-canadum-the-impact-of-crude-oil-exposure
#2
Derek Nelson, John D Stieglitz, Georgina K Cox, Rachael M Heuer, Daniel D Benetti, Martin Grosell, Dane A Crossley
Aerobic exercise capacity is dependent on the cardiorespiratory system's ability to supply oxygen at a rate that meets energetic demands. In teleost fish crude oil exposure, with the associated polycyclic aromatic hydrocarbons (PAH's), reduces exercise performance and this has been hypothesized to be due to compromised cardiovascular function. In this study, we test this hypothesis by simultaneously measuring cardiovascular performance, oxygen consumption, and swim performance in a pelagic teleost, the cobia (Rachycentron canadum)...
September 15, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28917645/anti-fibrinolytic-and-anti-microbial-activities-of-a-serine-protease-inhibitor-from-honeybee-apis-cerana-venom
#3
Jie Yang, Kwang Sik Lee, Bo Yeon Kim, Yong Soo Choi, Hyung Joo Yoon, Jingming Jia, Byung Rae Jin
Bee venom contains a variety of peptide constituents, including low-molecular-weight protease inhibitors. While the putative low-molecular-weight serine protease inhibitor Api m 6 containing a trypsin inhibitor-like cysteine-rich domain was identified from honeybee (Apis mellifera) venom, no anti-fibrinolytic or anti-microbial roles for this inhibitor have been elucidated. In this study, we identified an Asiatic honeybee (A. cerana) venom serine protease inhibitor (AcVSPI) that was shown to act as a microbial serine protease inhibitor and plasmin inhibitor...
September 14, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28888877/the-role-of-charge-in-the-toxicity-of-polymer-coated-cerium-oxide-nanomaterials-to-caenorhabditis-elegans
#4
Devrah A Arndt, Emily K Oostveen, Judy Triplett, D Allan Butterfield, Olga V Tsyusko, Blanche Collin, Daniel L Starnes, Jian Cai, Jon B Klein, Richard Nass, Jason M Unrine
This study examined the impact of surface functionalization and charge on ceria nanomaterial toxicity to Caenorhabditis elegans. The examined endpoints included mortality, reproduction, protein expression, and protein oxidation profiles. Caenorhabditis elegans were exposed to identical 2-5nm ceria nanomaterial cores which were coated with cationic (diethylaminoethyl dextran; DEAE), anionic (carboxymethyl dextran; CM), and non-ionic (dextran; DEX) polymers. Mortality and reproductive toxicity of DEAE-CeO2 was approximately two orders of magnitude higher than for CM-CeO2 or DEX-CeO2...
September 6, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28888876/hemolymph-and-gill-carbonic-anhydrase-are-more-sensitive-to-aquatic-contamination-than-mantle-carbonic-anhydrase-in-the-mangrove-oyster-crassostrea-rhizophorae
#5
Matheus Barbosa Dos Santos, Ignácio Evaristo Monteiro Neto, Sarah Rachel Candido de Souza Melo, Enelise Marcelle Amado
Carbonic anhydrase (CA) is a ubiquitous metalloenzyme of great importance in several physiological processes. Due to its physiological importance and sensitivity to various pollutants, CA activity has been used as biomarker of aquatic contamination. Considering that in bivalves the sensitivity of CA to pollutants seems to be tissue-specific, we proposed here to analyze CA activity of hemolymph, gill and mantle of Crassostrea rhizophorae collected in two tropical Brazilian estuaries with different levels of anthropogenic impact, in dry and rainy season...
September 6, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28888875/imazalil-exposure-induces-gut-microbiota-dysbiosis-and-hepatic-metabolism-disorder-in-zebrafish
#6
Cuiyuan Jin, Ting Luo, Zhihong Zhu, Zihong Pan, Jiajing Yang, Wenchao Wang, Zhengwei Fu, Yuanxiang Jin
The fungicide imazalil (IMZ) is used extensively to preserve freshness, prevent decay and control fungal infections in fruits, vegetables or other plants. Recently, some studies have reported that the real in aquatic systems have reached very high levels. Here, male adult zebrafish were exposed to 100 and 1000μg/L IMZ for 1, 7, 21days, and the gut microbiota and hepatic metabolism were evaluated. Exposure to a high concentration of IMZ for 21days decreased mucin secretion in the gut. Sequencing of the V3-V4 region of the bacterial 16S rRNA gene revealed a significant increase in the diversity of gut microbiota in male zebrafish...
September 6, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28851534/growth-blood-health-antioxidant-status-immune-response-and-resistance-to-aeromonas-hydrophila-of-juvenile-yellow-catfish-exposed-to-di-2-ethylhexyl-phthalate-dehp
#7
Lixia Yuan, Ming Li, Fanxing Meng, Yifu Gong, Yunxia Qian, Ge Shi, Rixin Wang
Triplicate groups of juvenile yellow catfish Pelteobagrus fulvidraco were exposed to three levels of DEHP (0, 0.1 and 0.5mgL(-1)) for 56days. Fish survival (100%) was not affected by different levels of ambient DEHP. Final body weight, weight gain, specific growth rate and feed intake of fish exposed to 0.5mgL(-1) DEHP were the highest. On the contrary, hepatosomatic index of fish exposed to 0.1 and 0.5mgL(-1) DEHP were the lowest. Serum total protein, glutamic-pyruvic transaminase, glutamic-oxaloacetic transaminase, glucose and triglycerides increased with the increasing concentrations of DEHP exposure...
August 26, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28847529/exposure-to-atrazine-alters-behaviour-and-disrupts-the-dopaminergic-system-in-drosophila-melanogaster
#8
Fernanda Hernandes Figueira, Natália de Quadros Oliveira, Lais Mattos de Aguiar, Ana Laura Escarrone, Ednei Gilberto Primel, Daniela Martí Barros, Carlos Eduardo da Rosa
Atrazine is an extensively used herbicide, and has become a common environmental contaminant. Effects on dopaminergic neurotransmission in mammals following exposure to atrazine have been previously demonstrated. Here, the effects of atrazine regarding behavioural and dopaminergic neurotransmission parameters were assessed in the fruit fly D. melanogaster, exposed during embryonic and larval development. Embryos (newly fertilized eggs) were exposed to two atrazine concentrations (10μM and 100μM) in the diet until the adult fly emerged...
August 26, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28823830/characterization-and-comparison-of-activity-profiles-exhibited-by-the-cave-and-surface-morphotypes-of-the-blind-mexican-tetra-astyanax-mexicanus
#9
Brian M Carlson, Joshua B Gross
Departure from normal circadian rhythmicity and exposure to atypical lighting cues has been shown to adversely affect human health and wellness in a variety of ways. In contrast, adaptation to extreme environments has led many species to alter or even entirely abandon their reliance upon cyclic environmental inputs, principally daily cycles of light and darkness. The extreme darkness, stability and isolation of cave ecosystems has made cave-adapted species particularly attractive systems in which to study the consequences of life without light and the strategies that allow species to survive and even thrive in such environments...
August 18, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28821466/endocrine-disrupting-effects-of-waterborne-fluoxetine-exposure-on-the-reproductive-axis-of-female-goldfish-carassius-auratus
#10
Jan A Mennigen, Jacob M Zamora, John P Chang, Vance L Trudeau
Evidence suggests that pharmaceuticals and personal care products reach urban watersheds, bioconcentrate in fish, and potentially disrupt physiological homeostasis. These impairments often affect hormone functions. Selective serotonin reuptake inhibitors (SRRIs) are increasingly studied with regards to their endocrine disrupting effects on teleost physiological processes, including reproduction. To examine whether FLX effects on the endocrine regulation of reproductive physiology in goldfish are sex-specific, we exposed sexually recrudescent female goldfish to two waterborne concentrations of FLX (0...
August 16, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28802889/ameliorative-effect-of-propolis-supplementation-on-alleviating-bisphenol-a-toxicity-growth-performance-biochemical-variables-and-oxidative-stress-biomarkers-of-nile-tilapia-oreochromis-niloticus-l-fingerlings
#11
Heba S Hamed, Mohsen Abdel-Tawwab
Bisphenol-A (BPA) is one of the important pollutants in aquatic ecosystems and its detrimental effect on fish has a great concern. Propolis is a natural immune-stimulant that has various biological and pharmacological activities. Thus, its capability to alleviate the toxic effect of BPA on Nile tilapia, Oreochromis niloticus (L.) performance was assessed in a study based on a 2×2 factorial design with two levels of ethanolic extract of propolis (EEP) and two waterborne BPA concentrations in triplicates. Fish (33...
August 9, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28778491/stinging-caterpillars-from-the-genera-podalia-leucanella-and-lonomia-in-misiones-argentina-a-preliminary-comparative-approach-to-understand-their-toxicity
#12
María Agustina Quintana, Juliana Mozer Sciani, Aline Vivian Vatti Auada, María Mercedes Martínez, Matías Nicolás Sánchez, Marcelo Larami Santoro, Hui Wen Fan, María Elisa Peichoto
Dermal contact with Lepidoptera specimens at their larval stage (caterpillar) may cause systemic and/or local envenomation. There are multiple venomous species of them in Argentina, but their overall venom composition is poorly known. Lately, several cases of envenomation have been reported in the Misiones province, Northeastern Argentina. Thus, this work aimed to compare the protein composition, and the enzymatic properties of bristle extracts from caterpillars belonging to the families Megalopygidae (Podalia ca...
August 2, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28757215/catch-a-tiger-snake-by-its-tail-differential-toxicity-co-factor-dependence-and-antivenom-efficacy-in-a-procoagulant-clade-of-australian-venomous-snakes
#13
Callum Lister, Kevin Arbuckle, Timothy N W Jackson, Jordan Debono, Christina N Zdenek, Daniel Dashevsky, Nathan Dunstan, Luke Allen, Chris Hay, Brian Bush, Amber Gillett, Bryan G Fry
A paradigm of venom research is adaptive evolution of toxins as part of a predator-prey chemical arms race. This study examined differential co-factor dependence, variations relative to dietary preference, and the impact upon relative neutralisation by antivenom of the procoagulant toxins in the venoms of a clade of Australian snakes. All genera were characterised by venoms rich in factor Xa which act upon endogenous prothrombin. Examination of toxin sequences revealed an extraordinary level of conservation, which indicates that adaptive evolution is not a feature of this toxin type...
July 27, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28757214/vulnerability-of-marsh-frog-pelophylax-ridibundus-to-the-typical-wastewater-effluents-ibuprofen-triclosan-and-estrone-detected-by-multi-biomarker-approach
#14
Halina I Falfushynska, Lesya L Gnatyshyna, Oksana Horyn, Oksana B Stoliar
Pharmaceutical and personal care products (PPCPs) are the environmental pollutants of growing concern. The aim of this study was to indicate the effects of typical PPCPs on the marsh frog Pelophylax ridibundus. We treated male frogs with waterborne ibuprofen (IBU, 250ng·L(-1)), triclosan (TCS, 500ng·L(-1)), or estrone (E1, 100ng·L(-1)) for 14days. Common vulnerability of the frogs was detected from dramatic decrease of Zn, total and metalated metallothionein (MT) concentrations, Zn/Cu ratio, the elevation of activity of glutathione-S-transferase, cathepsin D and DNA instability in the liver, the depletion of cholinesterase in the brain and cortisol in the blood plasma in all exposures...
July 27, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28757213/oxidative-stress-parameters-in-two-pelophylax-esculentus-complex-frogs-during-pre-and-post-hibernation-arousal-vs-heavy-metals
#15
Marko D Prokić, Slavica S Borković-Mitić, Imre I Krizmanić, Jelena J Mutić, Jelena P Gavrić, Svetlana G Despotović, Branka R Gavrilović, Tijana B Radovanović, Slađan Z Pavlović, Zorica S Saičić
In spring, frogs from temperate regions are faced with arousal-induced oxidative stress and exposure to various xenobiotics from the environment. The question is whether pollutants can significantly modify the antioxidative defense system (AOS) response of hibernators during recovery from hibernation. If this assumption is true, we would then expect different patterns of seasonal variations in the AOS between individuals exposed to different levels of pollution. To examine this assumption, we determined the relationship between seasonal variations of accumulated metals and AOS parameters in the skin and muscle of two frog species from the Pelophylax esculentus complex (P...
July 27, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28754376/characterization-of-mxr-activity-in-the-sea-anemone-bunodosoma-cangicum-exposed-to-copper
#16
Vanessa Abelaira Anjos, Juliana Zomer Sandrini, Cláudia Bueno Reis Martinez, Marta Marques Souza
Transmembrane proteins of the ABC family contribute to a multiple xenobiotic resistance (MXR) phenotype in cells, driving the extrusion of toxic substances. This phenotype promotes a high degree of protection against xenobiotics. The present study provides a better understanding of the MXR activity in the podal disk cells of Bunodosoma cangicum exposed to copper, and further establishes the relationship between protein activity (measured by accumulation of rhodamine-B) and bioaccumulation of copper in these cells...
July 25, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28743461/effects-of-subchronic-exposure-to-waterborne-cadmium-on-h-p-i-axis-hormones-and-related-genes-in-rare-minnows-gobiocypris-rarus
#17
Xiao-Hong Liu, Zhi-Jian Wang, Li Jin, Jing Huang, De-Yong Pu, De-Shou Wang, Yao-Guang Zhang
The H (hypothalamic)-P (pituitary)-I (interrenal) axis is critical in the stress response and other activities of fish. To further investigate cadmium (Cd) toxicity on the H-P-I axis and to identify its potential regulatory genes in fish, the adult female rare minnows (Gobiocypris rarus) were exposed to subchronic (5weeks) levels of waterborne Cd in the present study. This kind of treatment caused dose-dependent decline in fish growth, with significance in the high dose group (100μg/L). Correspondingly, low dose (5-50μg/L) waterborne Cd disrupted the endocrine system of H-P-I axis just at the secretion level, while high dose Cd disrupted both the secretion and synthesis of cortisol and its downstream signals in rare minnows, revealed by the significantly upregulation and positive correlation of corticosteroidogenic genes including MC2R, StAR, CYP11A1, and CYP11B1 in the kidney (including the interrenal tissue) (P<0...
July 22, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28697978/functional-characterization-of-bdb1-a-well-conserved-carboxylesterase-among-tephritid-fruit-flies-associated-with-malathion-resistance-in-bactrocera-dorsalis-hendel
#18
Luo-Luo Wang, Xue-Ping Lu, Guy Smagghe, Li-Wei Meng, Jin-Jun Wang
There are many evidences that insect carboxylesterase possess important physiological roles in xenobiotic metabolism and are implicated in the detoxification of organophosphate (OP) insecticides. Despite the ongoing resistance development in the oriental fruit fly, Bactrocera dorsalis (Hendel), the molecular basis of carboxylesterase and its ability to confer OP resistance remain largely obscure. This study was initiated to provide a better understanding of carboxylesterase-mediated resistance mechanism in a tephritid pest fly...
July 8, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28602910/in-vitro-screening-for-estrogenic-endocrine-disrupting-compounds-using-mozambique-tilapia-and-sea-bass-scales
#19
COMPARATIVE STUDY
Patrícia I S Pinto, M Dulce Estêvão, Soraia Santos, André Andrade, Deborah M Power
A wide range of estrogenic endocrine disruptors (EDCs) are accumulating in the environment and may disrupt the physiology of aquatic organisms. The effects of EDCs on fish have mainly been assessed using reproductive endpoints and in vivo animal experiments. We used a simple non-invasive assay to evaluate the impact of estrogens and EDCs on sea bass (Dicentrarchus labrax) and tilapia (Oreochromis mossambicus) scales. These were exposed to estradiol (E2), two phytoestrogens and six anthropogenic estrogenic/anti-estrogenic EDCs and activities of enzymes related to mineralized tissue turnover (TRAP, tartrate-resistant acid phosphatase and ALP, alkaline phosphatase) were measured...
September 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28428009/effect-of-methylparaben-in-artemia-franciscana
#20
COMPARATIVE STUDY
Amparo Comeche, María Martín-Villamil, Yolanda Picó, Inma Varó
In this study, the toxicity of methylparaben (MeP) an emerging contaminant, was analysed in the sexual species Artemia franciscana, due to its presence in coastal areas and marine saltworks in the Mediterranean region. The acute toxicity (24h-LC50) of MeP in nauplii was tested and its chronic effect (9days) evaluated by measuring survival and growth under two sublethal concentrations (0.0085 and 0.017mg/L). Also, the effect on several key enzymes involved in: antioxidant defences (catalase (CAT) and gluthathion-S-transferase (GST)), neural activity (cholinesterase (ChE)) and xenobiotic biotransformation (carboxylesterase (CbE), was assessed after 48h under sublethal exposure...
September 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
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