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Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP

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https://www.readbyqxmd.com/read/28323199/acute-toxicity-bioaccumulation-and-effects-of-dietary-transfer-of-silver-from-brine-shrimps-exposed-to-pvp-pei-coated-silver-nanoparticles-to-zebrafish
#1
José María Lacave, Álvaro Fanjul, Eider Bilbao, Nerea Gutierrez, Irantzu Barrio, Inmaculada Arostegui, Miren P Cajaraville, Amaia Orbea
The extensive use and release to the aquatic environment of silver nanoparticles (NPs) could lead to their incorporation into the food web. Brine shrimp larvae of 24h showed low sensitivity to the exposure to PVP/PEI-coated Ag NPs (5nm), with EC50 values at 24h of 19.63mg Ag L(-1), but they significantly accumulated silver after 24h of exposure to 100μg L(-1) of Ag NPs. Thus, to assess bioaccumulation and effects of silver transferred by the diet in zebrafish, brine shrimp larvae were exposed to 100ng L(-1) of Ag NPs as an environmentally relevant concentration or to 100μg L(-1) as a potentially effective concentration and used to feed zebrafish for 21days...
March 16, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28315791/neurotoxic-effects-molecular-responses-and-oxidative-stress-biomarkers-in-nile-tilapia-oreochromis-niloticus-linnaeus-1758-exposed-to-verapamil
#2
Malachy N O Ajima, Pramod K Pandey, Kundan Kumar, Nalini Poojary
Pharmaceutical drugs and their metabolites are detected in aquatic ecosystems and have been reported to cause ecotoxicological consequences to resident aquatic organisms The study investigated the effects of acute and long-term exposure to verapamil on activities of acetylcholinesterase and antioxidant enzymes as well as mRNA expression of stress-related genes in brain and muscle tissues of Nile tilapia, Oreochromis niloticus. The 96h LC50 of verapamil to O. niloticus was 2.29mgL(-1). Exposure to sub-lethal concentrations of verapamil (0...
March 16, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28288906/an-aop-analysis-of-selective-serotonin-reuptake-inhibitors-ssris-for-fish
#3
REVIEW
M Danielle McDonald
Pharmaceuticals and personal care products (PPCPs) are found in measureable quantities within the aquatic environment. Selective serotonin reuptake inhibitor (SSRI) antidepressants are one class of pharmaceutical compound that has received a lot of attention. Consistent with most PPCPs, the pharmacokinetics and physiological impacts of SSRI treatment have been well-studied in small mammals and humans and this, combined with the evolutionary conservation of the serotonergic system across vertebrates, allows for the read-across of known SSRI effects in mammals to potential SSRI impacts on aquatic organisms...
March 10, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28286098/hepatic-gene-expression-profiles-of-a-non-model-cyprinid-barbus-plebejus-chronically-exposed-to-river-sediments
#4
Nadia Casatta, Fabrizio Stefani, Luigi Viganò
In this study, we characterized the gene expression responses of the Padanian barbel (Barbus plebejus), a native benthivorous cyprinid with a very compromised presence within the fish community of the River Po. Barbel juveniles were exposed in the laboratory to two river sediments reflecting an upstream/downstream gradient of increasing contamination and collected from one of the most anthropized tributaries of the River Po. After 7months of exposure, hepatic transcriptional changes that were diagnostic of sediment exposure were assessed...
March 9, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28286097/effect-of-the-periodic-properties-of-toxic-stress-on-the-oscillatory-behaviour-of-glycolysis-in-yeast-evidence-of-a-toxic-effect-frequency
#5
C André, F Gagné
Starving and nondividing yeast cells induce changes in the electron donor nicotinamide adenine dinucleotide (NADH) levels in a cyclic and wave-like manner for over 90min. Yeast suspensions were used to examine the toxic effects of contaminants on the cyclic behaviour of metabolite changes during anaerobic glycolysis. The cyclic behaviour NADH levels in yeast cell suspensions starved for 2 to 5h was studied after the addition of 10mM glucose for 5min followed by 10mM KCN to block aerobic glycolysis. The effects of three toxic elements (CuSO4, silver nanoparticles-nAg, and GdCl3), known for their potential to alter glycolsysis, on NADH levels over time were examined during the 3-h starvation step...
March 9, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28274763/developmental-and-reproductive-toxicity-of-pvp-pei-coated-silver-nanoparticles-to-zebrafish
#6
Amaia Orbea, Nagore González-Soto, José María Lacave, Irantzu Barrio, Miren P Cajaraville
Cellular and molecular mechanisms of toxicity of silver nanoparticles (NPs) and their toxicity to fish embryos after waterborne exposure have been widely investigated, but much less information is available regarding the effect of Ag NPs on physiological functions such as growth or reproduction. In this work, the effects of waterborne exposure of adult zebrafish (Danio rerio) to PVP/PEI coated Ag NPs (~5nm) on reproduction (fecundity) were investigated. Moreover, the development of the embryos after parental exposure was compared with the development of embryos after direct waterborne exposure to the NPs...
March 6, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28274761/developmental-toxicity-in-flounder-embryos-exposed-to-crude-oils-derived-from-different-geographical-regions
#7
Jee-Hyun Jung, Eun-Hee Lee, Kwang-Min Choi, Un Hyuk Yim, Sung Yong Ha, Joon Geon An, Moonkoo Kim
Crude oils from distinct geographical regions have distinct chemical compositions, and, as a result, their toxicity may be different. However, developmental toxicity of crude oils derived from different geographical regions has not been extensively characterized. In this study, flounder embryos were separately exposed to effluents contaminated by three crude oils including: Basrah Light (BLO), Pyrenees (PCO), and Sakhalin Vityaz (SVO), in addition to a processed fuel oil (MFO-380), to measure developmental toxicity and for gene expressions...
March 6, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28274762/are-whale-sharks-exposed-to-persistent-organic-pollutants-and-plastic-pollution-in-the-gulf-of-california-mexico-first-ecotoxicological-investigation-using-skin-biopsies
#8
Maria Cristina Fossi, Matteo Baini, Cristina Panti, Matteo Galli, Begoña Jiménez, Juan Muñoz-Arnanz, Letizia Marsili, Maria Grazia Finoia, Dení Ramírez-Macías
The whale shark (Rhincodon typus) is an endangered species that may be exposed to micro- and macro-plastic ingestion as a result of their filter-feeding activity, particularly on the sea surface. In this pilot project we perform the first ecotoxicological investigation on whale sharks sampled in the Gulf of California exploring the potential interaction of this species with plastic debris (macro-, micro-plastics and related sorbed contaminants). Due to the difficulty in obtaining stranded specimens of this endangered species, an indirect approach, by skin biopsies was used for the evaluation of the whale shark ecotoxicological status...
March 5, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28268104/erratum-to-bothrops-fonsecai-snake-venom-activities-and-cross-reactivity-with-commercial-bothropic-antivenom-comp-biochem-physiol-c-191-2017-86-100
#9
Rita de Cássia O Collaço, Priscila Randazzo-Moura, Mariana L Tamascia, Igor Rapp F da Silva, Thalita Rocha, José C Cogo, Stephen Hyslop, Charles G Sanny, Léa Rodrigues-Simioni
No abstract text is available yet for this article.
March 4, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28257925/beneficial-effect-of-adipokinetic-hormone-on-neuromuscular-paralysis-in-insect-body-elicited-by-braconid-wasp-venom
#10
Haq Abdul Shaik, Archana Mishra, Dalibor Kodrík
The effect of Habrobracon hebetor venom and the role of the adipokinetic hormone (AKH) in poisoned adult females of the firebug Pyrrhocoris apterus were studied 24 and 48h after treatments. Venom application elicited total neuromuscular paralysis in firebugs, but the co-application of venom and Pyrap-AKH significantly reduced paralysis (up to 3.2 times) compared to the application of venom only. Although the mechanisms of their action are unknown, both agents might affect neuromuscular junctions. Venom application significantly increased the expression of both P...
February 28, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28257924/assessment-of-immune-status-of-yellowfin-seabream-acanthopagrus-latus-during-short-term-exposure-to-phenanthrene
#11
Mehrnaz Shirmohammadi, Negin Salamat, Mohammad Taghi Ronagh, Abdolali Movahedinia, Gholamreza Hamidian
The aim of the present investigation was to assess the immune status in yellowfin seabream (Acanthopagrus latus) exposed to different concentrations of phenanthrene (Phe) for 14days. In addition, the Phe accumulation in the fish muscle was measured during the experiment. Fish were injected with different concentrations (0, 2, 20 and 40mg/kg) of Phe and samples were taken from tissue and blood of fish 1, 4, 7 and 14days after injection. Exposure of fish to Phe caused a significant decrease in white blood cells, C3 and C4 levels, lysosomal membrane stability, lysozyme activity after 4days and antibacterial activity after 7days of the experiment...
February 28, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28257923/rna-seq-and-deg-based-comparison-of-developmental-toxicity-in-fish-embryos-of-two-species-exposed-to-iranian-heavy-crude-oil
#12
Jee-Hyun Jung, Junsu Ko, Eun-Hee Lee, Kwang-Min Choi, Moonkoo Kim, Un Hyuk Yim, Jae-Seong Lee, Won Joon Shim
To determine and compare the toxic effects of Iranian heavy crude oil (IHCO) on the embryonic development of two fish species, we examined transcriptome profiles using RNA-seq. The assembled contigs were 66,070 unigenes in olive flounder embryos and 76,498 unigenes in spotted seabass embryos. In the differential gene expression (DEG) profiles, olive flounder embryos showed different up- and down-regulated patterns than spotted seabass embryos in response to fresh IHCO (FIHCO) and weathered IHCO (WIHCO). In this work, we categorized DEG profiles into six pathways: ribosome, oxidative phosphorylation, Parkinson's disease, Alzheimer's disease, Huntington's disease, and cardiac muscle contraction, validating the expression patterns of 13 DEGs using real-time quantitative RT-PCR...
February 28, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28257922/effects-of-nicotine-on-zebrafish-a-comparative-response-between-a-newly-established-gill-cell-line-and-whole-gills
#13
K S Nathiga Nambi, S Abdul Majeed, G Taju, Sridhar Sivasubbu, V Sarath Babu, A S Sahul Hameed
A novel cell line, Danio rerio gill (DrG), derived from the gill tissue of zebrafish, was established and characterized. The cells were able to grow at a wide range of temperatures from 25°C to 32°C in Leibovitz's L-15 medium. The DrG cell line consists of epithelial-like cells with a diameter of 18-22μm. The cell line was characterized by mitochondrial 12S rRNA gene. Acute toxicity tests were conducted on D. rerio by exposing them to nicotine for 96h under static conditions. In vitro cytotoxicity of nicotine was assessed in DrG cell line using multiple endpoints such as 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT), Neutral Red assay, Alamar Blue assay and Coomassie Blue protein assay...
February 28, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28254493/the-physiological-role-and-toxicological-significance-of-the-non-metal-selective-cadmium-copper-metallothionein-isoform-differ-between-embryonic-and-adult-helicid-snails
#14
Veronika Pedrini-Martha, Raimund Schnegg, Pierre-Emmanuel Baurand, Annette deVaufleury, Reinhard Dallinger
Metal regulation is essential for terrestrial gastropods to survive. In helicid snails, two metal-selective metallothionein (MT) isoforms with different functions are expressed. A cadmium-selective isoform (CdMT) plays a major role in Cd(2+) detoxification and stress response, whereas a copper-selective MT (CuMT) is involved in Cu homeostasis and hemocyanin synthesis. A third, non-metal-selective isoform, called Cd/CuMT, was first characterized in Cantareus aspersus. The aim of this study was to quantify the transcriptional activity of all three MT genes in unexposed and metal-exposed (Cd, Cu) embryonic Roman snails...
February 22, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28232231/first-data-on-three-bivalve-species-exposed-to-an-intra-harbour-polymetallic-contamination-la-rochelle-france
#15
Marine Breitwieser, Amélia Viricel, Carine Churlaud, Benoit Guillot, Elie Martin, Pierre-Louis Stenger, Valérie Huet, Angélique Fontanaud, Hélène Thomas-Guyon
Evaluating diffuse sediment contamination in the environment is a major concern with the aim of reaching a good chemical and ecological state of the littoral zone. In this study the risks of chronic chemical contamination and consequences in the bivalves Crassostrea gigas, Mytilus sp. and Mimachlamys varia were evaluated in coastal environments. The objective here was to understand the anthropological phenomena that affect the functioning of the marina of La Rochelle (semi-closed environment). Harbours seeking ecomanagement accreditations (such as the international reference ISO 14001) constitute zones of interest to implement biomonitoring studies...
February 21, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28232230/analysis-of-the-acute-response-of-galleria-mellonella-larvae-to-potassium-nitrate
#16
Ronan Maguire, Martin Kunc, Pavel Hyrsl, Kevin Kavanagh
Potassium nitrate (E252) is widely used as a food preservative and has applications in the treatment of high blood pressure however high doses are carcinogenic. Larvae of Galleria mellonella were administered potassium nitrate to establish whether the acute effects in larvae correlated with those evident in mammals. Intra-haemocoel injection of potassium nitrate resulted in a significant increase in the density of circulating haemocytes and a small change in the relative proportions of haemocytes but haemocytes showed a reduced fungicidal ability...
February 20, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28223193/spinosad-induces-autophagy-of-spodoptera-frugiperda-sf9-cells-and-the-activation-of-ampk-mtor-signaling-pathway
#17
Mingjun Yang, Youwu Hao, Jufang Gao, Yang Zhang, Wenping Xu, Liming Tao
Spinosad, a high-selectivity neural toxin, has been widely used in agricultural production. However, the mode of action of spinosad on insect non-neural cells is not yet clear and hence requires further investigation. Therefore, to reveal the cytotoxic mechanisms of spinosad, we investigated whether and how it can induce autophagic cell death. After treating Sf9 cells with spinosad, the resulting autophagosome was observed by transmission electron microscopy and monodansylcadaverine staining. Interestingly, spinosad induced the accumulation of Beclin-1, degradation of p62, and intensification of LC3-B formation and translocation and thus autophagy, whereas, 3-MA treatment reverted the phenotype...
February 20, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28219785/transcriptional-alterations-induced-by-binary-mixtures-of-ethinylestradiol-and-norgestrel-during-the-early-development-of-zebrafish-danio-rerio
#18
Yan-Qiu Liang, Guo-Yong Huang, Jian-Liang Zhao, Wen-Jun Shi, Li-Xin Hu, Fei Tian, Shuang-Shuang Liu, Yu-Xia Jiang, Guang-Guo Ying
Synthetic estrogens and progestins are commonly used in human and veterinary medicine. After use, they reach aquatic environments via discharge of wastewaters from human and animals, thus posing potential risks to organisms. So far, very little is known about their combined effects in aquatic organisms. The aim of this study was to investigate the effects of binary mixtures of ethinylestradiol (EE2) and norgestrel (NGT) on embryonic zebrafish (Danio rerio) by measuring transcriptional alterations. Zebrafish embryos were exposed to EE2 and NGT alone or in combination at concentrations between 36 and 5513ngL(-1) for 96h post-fertilization (hpf)...
February 17, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28216010/uptake-of-benzo-a-pyrene-but-not-of-phenanthrene-is-inhibited-by-fatty-acids-in-intestinal-brush-border-membrane-vesicles-of-rainbow-trout-oncorhynchus-mykiss
#19
Stefan de Gelder, Liselot van Och, Jan Zethof, Thamar N M Pelgrim, Josef D Rasinger, Gert Flik, Marc H G Berntssen, Peter H M Klaren
Partial replacement of fish ingredients with vegetable ingredients has elevated levels of polycyclic aromatic hydrocarbons (PAHs) in Atlantic salmon reared on these feeds. PAH uptake in the intestinal tract is postulated to occur in association with lipid absorption and could well be affected by fatty acid composition. We therefore investigated the effects of a fish oil and vegetable oil fatty acid, eicosapentaenoic acid (EPA; 20:5n-3) and oleic acid (18:1n-9) respectively, on the uptake of benzo[a]pyrene (BaP) and phenanthrene (PHE) across the intestinal brush border membrane in the salmonid species rainbow trout (Oncorhynchus mykiss)...
February 12, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28216009/upregulating-nrf2-dependent-antioxidant-defenses-in-pacific-oysters-crassostrea-gigas-investigating-the-nrf2-keap1-pathway-in-bivalves
#20
Naissa Maria Danielli, Rafael Trevisan, Danielle Ferraz Mello, Kelvis Fischer, Vanessa Schadeck Deconto, Daiane da Silva Acosta, Adalto Bianchini, Afonso Celso Dias Bainy, Alcir Luiz Dafre
Analysis of the Pacific oyster Crassostrea gigas annotated genome revealed genes with conserved sequences belonging to typical cap 'n' collar Nrf2 domain, a major player in antioxidant protection, and domains belonging to Nrf2 cytoplasmic repressor (Keap1), but little is known about Nrf2/Keap1 induction in bivalves. C. gigas were exposed to waterborne 10 and 30μM curcumin, a known inducer of the mammalian Nrf2. Curcumin disappeared from the seawater after 10h, and accumulated in the gills (10h) and digestive gland (10-96h)...
February 12, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
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