journal
MENU ▼
Read by QxMD icon Read
search

Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP

journal
https://www.readbyqxmd.com/read/28529177/senecio-brasiliensis-impairs-eclosion-rate-and-induces-apoptotic-cell-death-in-larvae-of-drosophila-melanogaster
#1
Giulianna Echeverria Macedo, Karen Kich Gomes, Nathane Rosa Rodrigues, Illana Kemmerich Martins, Gabriel da Luz Wallau, Nélson Rodrigues de Carvalho, Litiele Cezar da Cruz, Dennis Guilherme da Costa Silva, Aline Augusti Boligon, Jeferson Luis Franco, Thaís Posser
Senecio brasilienis (Spreng) Less., is a species native from Brazil, popularly known as "maria mole", and known to induce hepatotoxicity due to its high content of Pyrrolizidine alkaloids. Despite its toxicity, this plant is widely used in Brazilian folk medicine. Considering the antagonizing effects described for S. brasiliensis, we describe here molecular markers involved in the toxicity of hydroalcoholic extract from leaves of S. brasiliensis (HESB) in Drosophila melanogaster. Phytochemical analysis of HESB revealed the presence of phenolic acids and flavonoids...
May 18, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28529176/impairment-of-antioxidant-mechanisms-in-japanese-medaka-oryzias-latipes-by-acute-exposure-to-aluminum
#2
Wilson F Ramírez-Duarte, Tomofumi Kurobe, Swee J Teh
Increasing aluminum (Al) concentrations in aquatic habitats as a result of anthropogenic acidification and industrialization is a global issue. Moreover, in extensive areas of the humid tropics and subtropics, high Al concentrations in freshwater are observed because of both naturally low pH and high Al concentrations in soil. Al increases production of reactive oxygen species and enhances oxidative damage in mammals. However, no studies have examined the effect of environmentally relevant concentrations of Al at low pH on oxidative stress in fish...
May 18, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28502899/the-expression-of-p450-genes-mediating-fenpropathrin-resistance-is-regulated-by-cncc-and-maf-in-tetranychus-cinnabarinus-boisduval
#3
Li Shi, Mengyao Wang, Yichao Zhang, Guangmao Shen, Haishan Di, Yue Wang, Lin He
Although overexpression of genes encoding detoxification enzymes is a well-known mechanism of pesticide resistance of mites, the regulators involved in this process are still illiterate. Previous studies in our laboratory demonstrated that the overexpression of six P450 genes contributes to fenpropathrin resistance in T. cinnabarinus. In this study, six transcription factor genes that likely regulate the expression of P450 genes were identified and characterized. Quantitative PCR (qPCR) analysis showed that three transcription factor genes were highly expressed in a fenpropathrin-resistant (FeR) strain of T...
May 11, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28501544/the-dna-methylation-status-alteration-of-two-steroidogenic-genes-in-gonads-of-rare-minnow-after-bisphenol-a-exposure
#4
Ting Zhang, Yan Liu, Hong Chen, Jiancao Gao, Yingying Zhang, Cong Yuan, Zaizhao Wang
Both cytochrome P450c17 (CYP17A1) and P-450 side chain cleavage (CYP11A1) play important roles in steroid biosynthesis. According to our previous studies, bisphenol A (BPA) could regulate the mRNA expression of cyp17a1 and cyp11a1 in rare minnow Gobiocypris rarus. However, the potential mechanism of the regulation is barely understood. In the present study, aiming to explore how BPA affects the mRNA expression of cyp17a1 and cyp11a1 in testes and ovaries of G. rarus, we firstly cloned 340-bp fragment of 5' flanking region of cyp11a1 and then detected the methylation level of CpG loci involved in 5' flanking of cyp11a1 and cyp17a1 and their mRNA expression levels...
May 10, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28476648/the-polycyclic-aromatic-hydrocarbons-benzo-a-pyrene-and-phenanthrene-inhibit-intestinal-lipase-activity-in-rainbow-trout-oncorhynchus-mykiss
#5
Stefan de Gelder, Øystein Sæle, Bas T H de Veen, Joëlle Vos, Gert Flik, Marc H G Berntssen, Peter H M Klaren
Elevated levels of polycyclic aromatic hydrocarbons (PAHs) are detected in aquafeeds where fish oils are (partially) replaced by vegetable oils. The highly lipophilic PAHs solubilize readily in oil droplets and micelles in the intestinal lumen that can affect enzymatic lipid digestion by altering lipase activity. We therefore investigated the effect of two PAHs, benzo[a]pyrene (BaP) and phenanthrene (PHE), on bile salt-activated lipase (BAL) activity in desalted luminal extracts of the proximal intestine of rainbow trout (Oncorhynchus mykiss) using the triacylglycerides rapeseed oil and fish oil as substrates...
May 3, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28476649/cuins2-zns-qd-exposure-induces-developmental-toxicity-oxidative-stress-and-dna-damage-in-rare-minnow-gobiocypris-rarus-embryos-and-larvae
#6
Li Liu, Yuan-Yuan Xiao, Yan-Hong Ji, Ming-Zhi Liu, Yao Chen, Yu-Lian Zeng, Yao-Guang Zhang, Li Jin
Chinese rare minnow (Gobiocypris rarus) embryos were used as an experimental model to investigate the effects of CuInS2/ZnS quantum dots (QDs) on the early life stages of G. rarus. Normal developmental parameters (survival rate, body length and average heart rate), biomarker genes [stress response (Hsp70), detoxification (Cyp1a), organizer function and axis formation (Wnt8α), and muscle (Mstn)], enzymatic activity and DNA damage were recorded as endpoints in the developing embryos/larvae after exposure until 96h post-fertilization (hpf)...
May 2, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28457947/influence-of-temperature-on-the-antioxidant-responses-and-lipid-peroxidation-of-two-species-of-tadpoles-rhinella-schneideri-and-physalaemus-nattereri-exposed-to-the-herbicide-sulfentrazone-boral-500sc%C3%A2
#7
Juliane Silberschmidt Freitas, Fabrício Barreto Teresa, Eduardo Alves de Almeida
Amphibians can experience large temperature fluctuations in their habitats, especially during the larval stage, when tadpoles are restricted to small and ephemeral ponds. Changes in water temperature can alter development, metabolism and behaviour of cold-blooded animals but also the toxicokinetics of chemicals in the environment. In Brazil, pesticides application is intensified during the rainy season, which is the period of reproduction for many amphibian species. We evaluated here the influence of temperature (28, 32, and 36°C) on the toxicity of the herbicide sulfentrazone (Boral®SC) in tadpoles of Physalaemus nattereri and Rhinella schneideri, by analysis of oxidative stress biomarkers...
April 27, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28457946/the-zebrafish-operculum-a-powerful-system-to-assess-osteogenic-bioactivities-of-molecules-with-pharmacological-and-toxicological-relevance
#8
Marco Tarasco, Vincent Laizé, João Cardeira, M Leonor Cancela, Paulo J Gavaia
Bone disorders affect millions of people worldwide and available therapeutics have a limited efficacy, often presenting undesirable side effects. As such, there is a need for novel molecules with bone anabolic properties. The aim of this work was to establish a rapid, reliable and reproducible method to screen for molecules with osteogenic activities, using the zebrafish operculum to assess bone formation. Exposure parameters were optimized through morphological analysis of the developing operculum of larvae exposed to calcitriol, a molecule with known pro-osteogenic properties...
April 27, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28457945/correlation-between-ontogenetic-dietary-shifts-and-venom-variation-in-australian-brown-snakes-pseudonaja
#9
Vittoria Cipriani, Jordan Debono, Jonathan Goldenberg, Timothy N W Jackson, Kevin Arbuckle, James Dobson, Ivan Koludarov, Bin Li, Chris Hay, Nathan Dunstan, Luke Allen, Iwan Hendrikx, Hang Fai Kwok, Bryan G Fry
Venom is a key evolutionary trait, as evidenced by its widespread convergent evolution across the animal kingdom. In an escalating prey-predator arms race, venoms evolve rapidly to guarantee predatory or defensive success. Variation in venom composition is ubiquitous among snakes. Here, we tested variation in venom activity on substrates relevant to blood coagulation among Pseudonaja (brown snake) species, Australian elapids responsible for the majority of medically important human envenomations in Australia...
April 27, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28428009/effect-of-methylparaben-in-artemia-franciscana
#10
Amparo Comeche, María Martín-Villamil, Yolanda Pico, Inma Varó
In this study, the toxicity of methylparaben (MeP) an emerging contaminant, was analyzed in the sexual species Artemia franciscana, due to its presence in coastal areas and marine saltworks in the Mediterranean region. The acute toxicity (24h-LC50) of MeP in nauplii was tested and its chronic effect (9days) evaluated by measuring survival and growth under two sublethal concentrations (0.0085 and 0.017mg/L). Also, the effect on several key enzymes involved in: antioxidant defences (catalase (CAT) and gluthathion-S-transferase (GST)), neural activity (cholinesterase (ChE)) and xenobiotic biotransformation (carboxylesterase (CbE), was assessed after 48h under sublethal exposure...
April 17, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28411055/ppar%C3%AE-ppar%C3%AE-and-srebp-1-pathways-mediated-waterborne-iron-fe-induced-reduction-in-hepatic-lipid-deposition-of-javelin-goby-synechogobius-hasta
#11
Guang-Hui Chen, Zhi Luo, Feng Chen, Xi Shi, Yu-Feng Song, Wen-Jing You, Xu Liu
The 42-day experiment was conducted to investigate the effects and mechanism of waterborne Fe exposure influencing hepatic lipid deposition in Synechogobius hasta. For that purpose, S. hasta were exposed to four Fe concentrations (0 (control), 0.36, 0.72 and 1.07μM Fe) for 42days. On days 21 and 42, morphological parameters, hepatic lipid deposition and Fe contents, and activities and mRNA levels of enzymes and genes related to lipid metabolism, including lipogenic enzymes (6PGD, G6PD, ME, ICDH, FAS and ACC) and lipolytic enzymes (CPTI, HSL), were analyzed...
April 11, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28392375/antibacterial-and-antibiotic-potentiating-activities-of-tropical-marine-sponge-extracts
#12
Rima Beesoo, Ranjeet Bhagooli, Vidushi S Neergheen-Bhujun, Wen-Wu Li, Alexander Kagansky, Theeshan Bahorun
Increasing prevalence of antibiotic resistance has led research to focus on discovering new antimicrobial agents derived from the marine biome. Although ample studies have investigated sponges for their bioactive metabolites with promising prospects in drug discovery, the potentiating effects of sponge extracts on antibiotics still remains to be expounded. The present study aimed to investigate the antibacterial capacity of seven tropical sponges collected from Mauritian waters and their modulatory effect in association with three conventional antibiotics namely chloramphenicol, ampicillin and tetracycline...
April 7, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28392374/evaluation-of-the-toxic-effect-of-endocrine-disruptor-bisphenol-a-bpa-in-the-acute-and-chronic-toxicity-tests-with-pomacea-lineata-gastropod
#13
André Lucas Correa de Andrade, Priscila Rafaela Leão Soares, Stephannie Caroline Barros Lucas da Silva, Marília Cordeiro Galvão da Silva, Thamiris Pinheiro Santos, Marilia Ribeiro Sales Cadena, Pierre Castro Soares, Pabyton Gonçalves Cadena
Bisphenol A (BPA) is a plasticizer and a risk when it interacts with organisms, and can cause changes in the development and reproduction of them. This study aimed to evaluate the effects of BPA, by acute and chronic toxicity tests with neonates and adults of Pomacea lineata. Adults and neonates were divided into groups exposed to BPA (1-20mg/L), or 17β-estradiol (1mg/L) and control in the acute and chronic toxicity tests. Behavior, heart rate, reproduction and hemolymph biochemical analysis were measured...
April 6, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28347745/seasonal-and-ontogenetic-changes-modulate-oxygen-consumption-and-antioxidant-defenses-in-the-cutlassfish-trichiurus-lepturus-pisces-trichiuridae
#14
Danilo Wilhelm Filho, César G Fraga, Alberto Boveris
Several oxidative stress markers and liver oxygen consumption were measured in different tissues of the marine fish Trichiurus lepturus in late summer and late winter, as well as in juveniles and adult females. Oxygen consumption in liver, superoxide dismutase (SOD) and catalase (CAT) activity in liver, red cells, lens and roe, vitamin E, ubiquinol10, β-carotene in liver, red cells, and roe, as well as contents of reduced glutathione (GSH) and lipoperoxidation (TBARS) in red cells were evaluated. Regarding ontogeny, compared to adult fish, juveniles showed significant higher SOD activity in liver and lens, as well as higher liver contents of vitamin E...
March 24, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28347744/the-development-of-cellular-immune-defence-in-marine-medaka-oryzias-melastigma
#15
Frauke Seemann, Drew Ryan Peterson, Michael Wai Lun Chiang, Doris Wai Ting Au
Environmentally induced alterations of the immune system during sensitive developmental stages may manifest as abnormalities in immune organ configuration and/or immune cell differentiation. These not only render the early life stages more vulnerable to pathogens, but may also affect the adult immune competence. Knowledge of these sensitive periods in fish would provide an important prognostic/diagnostic tool for aquatic risk assessment of immunotoxicants. The marine medaka Oryzias melastigma is an emerging seawater fish model for immunotoxcology...
March 24, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28344012/signaling-pathways-involved-in-metal-based-nanomaterial-toxicity-towards-aquatic-organisms
#16
Amélie Châtel, Catherine Mouneyrac
Environmental risk assessment of engineered nanomaterials (ENMs) is an emergent field since nanotechnology industry is rapidly growing due to the interesting physicochemical properties of nanomaterials. Metal-based nanomaterials are among the most rapidly commercialized materials and their toxicity towards aquatic animals has been investigated at different levels of the biological organization. The objective of this synthesis review is to give an overview of the signaling molecules that have a key role in metal-based NM mediated cytotoxicity in both marine and freshwater organisms...
March 23, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28341216/effects-of-methimazole-on-drosophila-glucolipid-metabolism-in-vitro-and-in-vivo
#17
Qi Wei, Bo Hu, Yuan Xue, David Kibe Mburu, Xian Tao, Jianya Su
Methimazole (MMI) is an antithyroid agent widely used in the treatment of hyperthyroidism, and metabolized by cytochrome P450 enzymes and flavin-containing monooxygenases in mammals. However, drug overdose and the inadequate detoxification of the metabolite(s) are responsible for hepatocellular damage and organ dysfunction. Depending on the desired properties, Drosophila melanogaster has recently emerged as an ideal model organism for the study of human diseases. Here we investigated the changes in metabolic profiles and mRNA expressions related to glucolipid metabolism in response to treatment with MMI in Drosophila...
March 21, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28341215/identification-and-molecular-characterization-of-cytochrome-p450-cyp450-family-genes-in-the-marine-ciliate-euplotes-crassus-the-effect-of-benzo-a-pyrene-and-beta-naphthoflavone
#18
Bora Yim, Hokyun Kim, Jisoo Kim, Haeyeon Kim, Eun-Ji Won, Young-Mi Lee
Marine ciliate Euplotes crassus, a single-cell eukaryote, and has been considered as a model organism for monitoring of environmental pollutions in sediments. Cytochrome P450 (CYP450) monooxygenase are phase I enzyme involved in detoxification of environmental pollutants, such as polycyclic aromatic hydrocarbons (PAHs). However, little information on CYP450 family genes in ciliate is available. In the present study, acute toxicity of PAH, benzo[a]pyrene (B[a]P) and PAH-like model compound, beta-naphthoflavone (β-NF), was investigated; full-length cDNA sequences and genomic structure of five CYP450 genes (CYP5680A1, CYP5681A1, CYP5681B1, CYP5682A1, and CYP5683A1) were analyzed; and finally their activities and transcriptional changes were measured after exposure to PAHs for 48h...
March 21, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28323199/acute-toxicity-bioaccumulation-and-effects-of-dietary-transfer-of-silver-from-brine-shrimps-exposed-to-pvp-pei-coated-silver-nanoparticles-to-zebrafish
#19
José María Lacave, Álvaro Fanjul, Eider Bilbao, Nerea Gutierrez, Irantzu Barrio, Inmaculada Arostegui, Miren P Cajaraville, Amaia Orbea
The extensive use and release to the aquatic environment of silver nanoparticles (NPs) could lead to their incorporation into the food web. Brine shrimp larvae of 24h showed low sensitivity to the exposure to PVP/PEI-coated Ag NPs (5nm), with EC50 values at 24h of 19.63mg Ag L(-1), but they significantly accumulated silver after 24h of exposure to 100μg L(-1) of Ag NPs. Thus, to assess bioaccumulation and effects of silver transferred by the diet in zebrafish, brine shrimp larvae were exposed to 100ng L(-1) of Ag NPs as an environmentally relevant concentration or to 100μg L(-1) as a potentially effective concentration and used to feed zebrafish for 21days...
March 16, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28315791/neurotoxic-effects-molecular-responses-and-oxidative-stress-biomarkers-in-nile-tilapia-oreochromis-niloticus-linnaeus-1758-exposed-to-verapamil
#20
Malachy N O Ajima, Pramod K Pandey, Kundan Kumar, Nalini Poojary
Pharmaceutical drugs and their metabolites are detected in aquatic ecosystems and have been reported to cause ecotoxicological consequences to resident aquatic organisms. The study investigated the effects of acute and long-term exposure to verapamil on activities of acetylcholinesterase and antioxidant enzymes as well as mRNA expression of stress-related genes in brain and muscle tissues of Nile tilapia, Oreochromis niloticus. The 96h LC50 of verapamil to O. niloticus was 2.29mgL(-1). Exposure to sub-lethal concentrations of verapamil (0...
March 16, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
journal
journal
35097
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"