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Modern Rheumatology

Elif Çelikel, Z Birsin Özçakar, Semanur Özdel, Nilgün Çakar, Fatma Aydın, Seda Şahin, Fatoş Yalçınkaya
OBJECTIVES: Familial Mediterranean fever (FMF) is an autosomal recessive disease characterised by recurrent, self limited attacks of fever with serositis. Recently, it was shown that FMF patients with early disease onset have more severe disease. The aim of this study was to describe the demographic, clinical and genetic features of FMF patients who had disease onset during the neonatal period. METHODS: Medical records of all patients diagnosed as FMF and had been seen in the outpatient clinic of Pediatric Rheumatology department between January 2013-January 2014 were retrospectively evaluated...
July 14, 2018: Modern Rheumatology
Yoshiya Tanaka, Tsuneyo Mimori, Hisashi Yamanaka, Ryo Nakajima, Kazuo Morita, Junko Kimura, Tsutomu Takeuchi
OBJECTIVES: This real-world study assessed the effectiveness and safety outcomes of initiating adalimumab and methotrexate (≥12 mg/week) with adjustable dosing in Japanese patients with early rheumatoid arthritis (RA). METHODS: This single-arm, prospective postmarketing observational study (conducted from September 2012 to March 2017 at 119 sites) enrolled biologic-naïve patients with early RA (≤2 years duration) and a Disease Activity Score in 28 joints using C-reactive protein (DAS28-CRP) >3...
July 14, 2018: Modern Rheumatology
Masayoshi Harigai, Kenji Nagasaka, Koichi Amano, Masashi Bando, Hiroaki Dobashi, Tamihiro Kawakami, Kan Kishibe, Yohko Murakawa, Joichi Usui, Takashi Wada, Eiichi Tanaka, Eishu Nango, Takeo Nakayama, Michi Tsutsumino, Kunihiro Yamagata, Sakae Homma, Yoshihiro Arimua
OBJECTIVE: The Japan Research Committee for Intractable Vasculitis has fully revised the clinical practice guidelines (CPG) for the management of antineutrophil cytoplasmic antibody-associated vasculitis (AAV) to improve and standardize the medical treatment of the disease in Japan. METHODS: The previous CPG was published in a classical review style in Japanese in 2012 and 2014. We adopted the Grading of Recommendations Assessment, Development and Evaluation system for this revision, and various stakeholders, including patients, participated in it...
July 13, 2018: Modern Rheumatology
Ali Taylan, Merih Birlik, Gokce Kenar, Burak Toprak, Barıs Gundogdu, Oguz Gurler, Burak Karakas, Barıs Akinci, Ali R Sisman
OBJECTIVES: We explored the interactions of osteoprotegerin (OPG) with biomarkers of bone turnover and cytokines, including soluble receptor activator for nuclear factor kappa beta ligand (sRANKL), tumor necrosis factor-related apoptosis-induced ligand (TRAIL), and Wnt inhibitors in osteoporosis, vasculopathy and fibrosis related to systemic sclerosis (SSc). METHODS: The study included 46 SSc patients and 30 healthy controls. Skin thickness, pulmonary fibrosis and/or hypertension, digital ulcers, and calcinosis cutis of SSc patients were assessed...
July 13, 2018: Modern Rheumatology
Kenji Nagasaka, Masayoshi Harigai, Noboru Hagino, Akinori Hara, Tetsuya Horita, Taichi Hayashi, Mitsuyo Itabashi, Satoshi Ito, Yasuhiro Katsumata, Soko Kawashima, Taio Naniwa, Ken-Ei Sada, Eishu Nango, Takeo Nakayama, Michi Tsutsumino, Kunihiro Yamagata, Sakae Homma, Yoshihiro Arimura
OBJECTIVES: To provide evidence for the revision of clinical practice guideline (CPG) for the management of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) by the Japan Research Committee for Intractable Vasculitis. METHODS: PubMed, CENTRAL, and the Japan Medical Abstracts Society were searched for articles published between January 1994 and January 2015 to conduct systematic review (SR), and the quality of evidence was assessed with GRADE approach...
July 12, 2018: Modern Rheumatology
Taiki Ando, Yoshiyuki Abe, Yukari Endo, Kurisu Tada, Ken Yamaji, Naoto Tamura
OBJECTIVE: Pneumocystis pneumonia (PCP) is a serious complication in patients with rheumatic diseases who are receiving immunosuppressive therapy. These patients have a higher mortality from PCP than those with human immunodeficiency virus. We examined factors associated with poor prognosis in patients with rheumatic diseases and evaluated PCP treatment in this population. METHODS: This retrospective, single-center, observational cohort study included 31 patients with rheumatic diseases who were admitted to Juntendo University Hospital for PCP treatment from June 2006 to December 2017...
July 4, 2018: Modern Rheumatology
Takahiro Ochi, Takashi Sawai, Kenya Murakami, Akihisa Kamataki, Miwa Uzuki, Tetsuya Tomita, Hideki Tsuboi, Kensuke Ochi, Kosuke Ebina, Shunsei Hirohata, Peter E Lipsky
Nurse-like cells (NLCs) established from bone marrow and synovial tissue of rheumatoid arthritis (RA) patients were found to promote maturation and differentiation of B lineage cells as well as T cells. In co-culture of RA-NLCs and B cells, tight physical interactions (pseudoemperipolesis) developed, which resulted in activation of both cell types. RA-NLCs also supported myeloid cell maturation, promoting their differentiation into tartrate-resistant acid phosphatase-positive mononuclear cells, which are precursor cells of osteoclasts...
June 29, 2018: Modern Rheumatology
Takeharu Suzuki, Nobuyuki Horita, Masaki Takeuchi, Takehito Ishido, Yuki Mizuki, Ryuta Mizuki, Tatsukata Kawagoe, Etsuko Shibuya, Kentaro Yuta, Takahiro Yamane, Takahiko Hayashi, Akira Meguro, Mizuho Ishido, Kaoru Minegishi, Ryusuke Yoshimi, Yohei Kirino, Shingo Kato, Jun Arimoto, Takeshi Fukumoto, Yoshiaki Ishigatsubo, Michiko Kurosawa, Mitsuhiro Takeno, Takeshi Kaneko, Nobuhisa Mizuki
BACKGROUND: Clinical data of patients with entro-, vasculo-, and neuro-variant possible Behçet's disease (BD) based on Japanese criteria has not yet comprehensively reported. METHODS: This ongoing nationwide registration has been carried out by the Japanese Ministry of Health, Labour and Welfare. The Ministry asked physicians who diagnosed a patient with confirmed or possible BD to register the patient data by filling out a registration form. The Ministry provided us with the dataset after un-linkable anonymization...
June 28, 2018: Modern Rheumatology
Takeshi Mochizuki, Katsunori Ikari, Koichiro Yano, Motoaki Sato, Ken Okazaki
OBJECTIVE: To examine the deterioration of interstitial lung disease (ILD) in patients with rheumatoid arthritis (RA) treated with abatacept over the long-term. METHODS: We examined 131 patients with RA who had been treated with abatacept for more than 1 year. All patients underwent high-resolution computed tomographic (HRCT) scanning of the chest before administration of abatacept, and we examined deterioration of ILD over a follow-up period after administration of abatacept was initiated...
June 28, 2018: Modern Rheumatology
Shinsuke Yasuda
Systemic lupus erythematosus (SLE) is a highly heterogeneous autoimmune disease that preferentially affects women of child-bearing age. Most current treatments for SLE with the exception of belimumab are not target-specific. Non-targeted therapy such as corticosteroids, cyclophosphamide, and other immunosuppressive drugs results in unwanted adverse effects. Although progress in treatment, including supportive therapy, has dramatically improved the prognosis of patients with SLE, better treatment drugs and protocols with fewer adverse effects and higher efficacy for the most severe form of SLE are needed...
June 27, 2018: Modern Rheumatology
Kenji Oku, Tatsuya Atsumi
Systemic lupus erythematosus (SLE) is a representative systemic autoimmune disease that has various types of manifestations in multiple organs. Additionally, SLE is one of the most variable diseases in its epidemiology and etiology with heterogenous types of immune dysfunction. Since the word 'lupus' has first appeared in the literature in the Middle Ages, clinical/pathological knowledges have massively accumulated that contributed to the establishments and improvements of classification criteria, therapeutic agents or assessments of disease activity...
June 27, 2018: Modern Rheumatology
Kosaku Murakami, Masahiro Sekiguchi, Shintaro Hirata, Takao Fujii, Kiyoshi Matsui, Satoshi Morita, Koichiro Ohmura, Yutaka Kawahito, Norihiro Nishimoto, Tsuneyo Mimori, Hajime Sano
OBJECTIVE: To investigate the effect of abatacept (ABA) on preventing joint destruction in biological disease-modifying anti-rheumatic drug (bDMARD)-naïve rheumatoid arthritis (RA) patients in real-world clinical practice. PATIENTS AND METHODS: RA patients were collected from the ABROAD (ABatacept Research Outcomes as a First-line Biological Agent in the Real WorlD) study cohort. They had moderate or high disease activity and were treated with ABA as a first-line bDMARD...
June 27, 2018: Modern Rheumatology
Aida Malek Mahdavi, Alireza Khabbazi, Barmak Yaaghoobian, Morteza Ghojazadeh, Ramin Agamohammadi, Atefeh Kheyrollahiyan, Nadereh Rashtchizadeh
OBJECTIVE: Behcet's disease (BD) is an inflammatory disease and smoking may have a role in its triggering. This case-control study was conducted to investigate the association between smoking and the risk of BD. METHODS: We included 192 patients with BD and 822 healthy siblings of patient with BD and 373 healthy unrelated persons as control groups. Demographic data and smoking history of patients and their siblings were obtained by direct and in some cases by telephone interview with the participants...
June 26, 2018: Modern Rheumatology
Toshifumi Fujiwara, Kenjiro Fujimura, Satoshi Hamai, Satoshi Kamura, Yasuharu Nakashima, Hisaaki Miyahara
OBJECTIVES: This study retrospectively investigated the mid-term outcome of Legacy constrained condylar knee (LCCK) prosthesis in patients with rheumatoid arthritis (RA) having severe varus/valgus deformity, instability and/or bone loss. METHODS: Between January 2000 and December 2015, LCCK prostheses had been performed in 32 knees of 25 patients with RA, and 23 knees of 17 patients of the postoperative follow-up minimum 2 years were analyzed in this study (Primary: 14 knees, Revision: 9 knees)...
June 8, 2018: Modern Rheumatology
Kosuke Ebina, Akira Miyama, Hideki Tsuboi, Shoichi Kaneshiro, Masataka Nishikawa, Hajime Owaki, Shigeyoshi Tsuji, Makoto Hirao, Yuki Etani, Atsushi Goshima, Jun Hashimoto, Hideki Yoshikawa
OBJECTIVES: To evaluate the effectiveness of add-on iguratimod (IGU) in patients with rheumatoid arthritis (RA) who showed an inadequate response to tocilizumab (TCZ), especially patients who were intolerant of an effective dose of methotrexate (MTX). METHODS: Thirty-one patients with RA (22 women, age 62.4 years, disease duration 13.8 years, prior TCZ duration 35.7 months, 25 intravenous [8 mg/kg/4 weeks] and 6 subcutaneous [162 mg/2 weeks] TCZ treatments, concomitant MTX 8...
June 8, 2018: Modern Rheumatology
(no author information available yet)
No abstract text is available yet for this article.
June 5, 2018: Modern Rheumatology
Yasushi Wako, Junichi Nakamura, Shigeo Hagiwara, Michiaki Miura, Yawara Eguchi, Takane Suzuki, Sumihisa Orita, Kazuhide Inage, Yuya Kawarai, Masahiko Sugano, Kento Nawata, Kensuke Yoshino, Yoshitada Masuda, Koji Matsumoto, Seiji Ohtori
OBJECTIVE: The aim was to compare the fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values of the sciatic and femoral nerves in patients with unilateral osteoarthritis of the hip (OA) and osteonecrosis of the femoral head (ONFH) using diffusion tensor imaging (DTI) and to investigate the mechanism of hip pain. METHODS: Forty-four patients (22 OA and 22 ONFH) underwent DTI of the sciatic and femoral nerves at the level of the hip joint and the S1 roots to visualize the tractography and quantify the FA and ADC values...
June 2, 2018: Modern Rheumatology
Christian Goess, Christopher M Harris, Sara Murdock, Richard W McCarthy, Erik Sampson, Rachel Twomey, Suzanne Mathieu, Regina Mario, Matthew Perham, Eric R Goedken, Andrew J Long
OBJECTIVES: Bruton's Tyrosine Kinase (BTK) is a non-receptor tyrosine kinase required for intracellular signaling downstream of multiple immunoreceptors. We evaluated ABBV-105, a covalent BTK inhibitor, using in vitro and in vivo assays to determine potency, selectivity, and efficacy to validate the therapeutic potential of ABBV-105 in inflammatory disease. METHODS: ABBV-105 potency and selectivity were evaluated in enzymatic and cellular assays. The impact of ABBV-105 on B cell function in vivo was assessed using mechanistic models of antibody production...
June 2, 2018: Modern Rheumatology
Hiroshi Ebe, Isao Matsumoto, Atsumu Osada, Izumi Kurata, Hoshimi Kawaguchi, Yuya Kondo, Hiroto Tsuboi, Takayuki Sumida
No abstract text is available yet for this article.
June 2, 2018: Modern Rheumatology
Sunggun Lee, Min Wook So, Eunyoung Ahn
OBJECTIVES: To assess long-term adherence and persistence to febuxostat (FBX) and factors that might contribute to non-adherence and non-persistence to FBX in male patients with gout during a 3-year period. METHODS: Adherence to FBX was assessed by the clinic nurses through pill counts at the scheduled visits and non-adherence was defined as less than 80% of the prescribed dose taken. Non-persistence was defined as discontinuation of FBX longer than 60 days. RESULTS: A total of 220 patients were recruited...
June 1, 2018: Modern Rheumatology
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