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Modern Rheumatology

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https://www.readbyqxmd.com/read/28397581/comparison-of-the-effects-of-denosumab-with-either-active-vitamin-d-or-native-vitamin-d-on-bone-mineral-density-and-bone-turnover-markers-in-postmenopausal-osteoporosis
#1
Takako Suzuki, Yukio Nakamura, Mizue Tanaka, Mikio Kamimura, Shota Ikegami, Shigeharu Uchiyama, Hiroyuki Kato
Osteoporosis is a worldwide health concern. Although treatment with denosumab plus the active vitamin D alfacalcidol has been found to improve femoral neck (FN) and distal forearm bone mineral density (BMD), there have been no reports on the efficacy or adverse effects of denosumab plus eldecalcitol (ELD) in primary osteoporosis patients. Fifty-six treatment-naïve post-menopausal women with primary osteoporosis were recruited and divided into denosumab plus native vitamin D or denosumab plus ELD. Ultimately, 26 subjects in the native vitamin D group and 24 in the ELD group were analyzed...
April 11, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28397554/sauv%C3%A3-kapandji-procedure-with-headless-compression-screw-in-patients-with-rheumatoid-arthritis
#2
Atsushi Maeda, Taku Suzuki, Masaki Hasegawa, Takashi Kuroiwa, Kanae Shizu, Katsuhiko Hayakawa, Takashi Tsuji, Katsuji Suzuki, Harumoto Yamada
OBJECTIVE: We examined the surgical outcomes of the Sauvé-Kapandji (S-K) procedure using a headless compression screw and a metal cancellous screw in patients with rheumatoid arthritis (RA). METHODS: This retrospective study included 41 RA patients who underwent the S-K procedure for distal radioulnar joint disorders with two screws: headless compression screws (HCS group, n = 20) and cannulated cancellous screws (CCS group, n = 21). Clinical and radiographic outcomes were assessed 1 year after surgery...
April 11, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28395637/safety-and-effectiveness-of-high-dose-methotrexate-over-8%C3%A2-mg-week-in-2838-japanese-patients-with-rheumatoid-arthritis-a-postmarketing-surveillance-report
#3
Yasuo Suzuki, Naonobu Sugiyama, Yuri Fukuma, Noriko Sugiyama, Takeshi Kokubo
OBJECTIVES: To confirm the safety and effectiveness of high-dose (>8 mg/week) methotrexate (MTX) for the treatment of rheumatoid arthritis in Japan. METHODS: A postmarketing surveillance program enrolled Japanese patients with rheumatoid arthritis starting on high-dose MTX followed up for either 24- or 52-weeks. Analyses for safety, risk factors affecting safety, and effectiveness were conducted. RESULTS: The safety/effectiveness analysis sets included 2838/2779 and 335/326 patients in the 24-weeks and 52-weeks follow-up groups, respectively...
April 11, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28395604/prevalence-and-risk-factors-of-hyperuricemia-results-of-the-kailuan-cohort-study
#4
Liufu Cui, Lingmin Meng, Guanying Wang, Xiaodong Yuan, Zhanguo Li, Rong Mu, Shouling Wu
OBJECTIVE: The objective of this study is to determine the serum uric acid (SUA) level and the prevalence of hyperuricemia (HUA) in Chinese population. METHODS: We conducted a cross-sectional study among 100,226 employees (79.9% male) of the Kailuan Group using physical examination data in 2006-2007. HUA was defined as SUA >356.9 μmol/L (6.0 mg/dL) for women and SUA >416.4 μmol/L (7.0 mg/dL) for men. We investigated crude and age adjusted HUA prevalence and compared characteristics of subjects with and without HUA in men and women using multivariate logistic regression...
April 11, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28395582/current-trends-in-medical-english-education-and-the-japan-college-of-rheumatology-international-school
#5
Eric Hajime Jego, Olga Amengual
In light of the present revolution happening in medical education in Japan as medical schools implement new curricula to conform to global standards, there is a growing demand for more internationalization and higher quality practical medical English education. In response, many institutions including governmental organizations, universities and academic associations are moving ahead with new initiatives to adapt to these changing demands. This paper reviews the current trends and innovations in medical English education in Japan...
April 11, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28395581/a-case-control-study-of-rheumatoid-arthritis-revealed-abdominal-obesity-and-environmental-risk-factor-interactions-in-northern-china
#6
Lingyu Fu, Jianming Zhang, Lei Jin, Yao Zhang, Saisai Cui, Meng Chen
BACKGROUND: The aim of this study was to evaluate new and previously hypothesized environmental risk factors and their interaction with rheumatoid arthritis (RA). METHODS: Four hundred patients recently diagnosed with RA and 400 controls frequency-matched by gender and birth year using Propensity Score Matching (PSM) were selected from northern China. Investigation was performed using self-reported data from interviewer-administered surveys. Associations between exposure variables and risk of RA were evaluated using multifactor non-conditional logistic regression...
April 11, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/27846750/survey-on-attitudes-regarding-eular-recommendations-for-the-role-of-nurses-involved-in-medical-care-of-patients-with-chronic-inflammatory-arthritis-in-japan
#7
Mie Fusama, Hideko Nakahara, Yvonne van Eijk-Hustings, Susan Oliver, Tsutomu Takeuchi
OBJECTIVE: We seek to evaluate the opinions of nurses and doctors in Japan regarding EULAR recommendations for nurses' roles in the management of chronic inflammatory arthritis. METHODS: This is a cross-sectional survey within Japan. We randomly selected nurses and doctors engaged in consultation of patients with rheumatoid arthritis (RA) and assessed their agreement and opinions on the feasibility of implementing EULAR recommendations, including potential barriers...
April 10, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28388293/long-term-safety-and-effectiveness-of-adalimumab-for-the-treatment-of-japanese-patients-with-rheumatoid-arthritis-3-year-results-from-a-postmarketing-surveillance-of-552-patients
#8
Masayoshi Harigai, Tsuyoshi Tsuchiya, Katsuyoshi Kawana, Sarina Kurimoto
OBJECTIVES: To determine the safety and effectiveness of and identify associated factors in long-term adalimumab (ADA) treatment of Japanese patients with rheumatoid arthritis (RA). METHODS: Of 7740 patients participating in the all-case postmarketing surveillance study, 552 were enrolled in the present study and observed for 3 years. The safety and effectiveness of ADA were analyzed in 509 and 430 patients, respectively. RESULTS: Adverse drug reactions (ADRs) were reported in 34...
April 7, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28350246/frequency-presentation-and-outcome-of-takayasu-arteritis-in-western-australia
#9
Krista Makin, Maxine Isbel, Johannes Nossent
OBJECTIVES: Takayasu arteritis (TAK) is large-vessel vasculitis that predominantly affects young women. There is worldwide variation in the frequency of TAK depending on genetic and/or environmental factors. With Australian data lacking, we describe the epidemiology, clinical features and outcomes of TAK in Western Australia (WA). METHODS: Retrospective case cohort study of incident TAK cases between 1 January 2000 and 30 June 2015 in WA identified from multiple sources...
March 28, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28333570/plantar-pressure-and-surgical-indication-of-toe-arthroplasty-for-rheumatoid-forefoot-deformity
#10
Hyunho Lee, Hajime Ishikawa, Yusuke Miyagawa, Chinatsu Takai, Yumi Nomura, Tetsuya Nemoto, Daisuke Kobayashi, Asami Abe, Hiroshi Otani, Satoshi Ito, Kiyoshi Nakazono, Takao Ishii, Shu Saito, Yasuaki Tokuhashi, Akira Murasawa
OBJECTIVES: The objective of this study is to clarify the surgical indication for rheumatoid forefoot deformity according to background characteristics and plantar pressure. METHODS: Patients with rheumatoid arthritis were divided into a non-surgical group (group N) and a surgical group (group S). The former consisted of 225 ft, and the latter consisted of 88 ft. DAS28, Japanese Society for Surgery of the Foot rheumatoid arthritis foot and ankle scale (JSSF scale) and hallux valgus angle (HVA) were evaluated as background characteristics...
March 23, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28271948/successful-adalimumab-treatment-and-usefulness-of-capsule-endoscopy-for-gut-inflammation-concomitant-with-ankylosing-spondylitis
#11
Shinji Ota, Hirotake Sakuraba, Hiroto Hiraga, Keisuke Hasui, Miwa Satake, Norihiro Hanabata, Yui Akemoto, Rina Watanabe, Nahoko Tanaka, Yoh Ishiguro, Masanori Tanaka, Shinsaku Fukuda
Here we describe a 20-year-old man with ankylosing spondylitis and gut inflammation, who was successfully treated with adalimumab. Capsule endoscopy and ileocolonoscopy showed multiple erosions and aphthoid ulcers in the ileum and the ileocecal valve. Immunohistochemical analysis of the terminal ileum demonstrated that the number of IL-23p19 expressing macrophages was increased. Adalimumab was administered, and his back pain and abdominal symptoms improved. Adalimumab might be an effective treatment for gut inflammation related to ankylosing spondylitis...
March 8, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28271947/health-assessment-questionnaire-disability-index-haq-di-score-at-the-start-of-biological-disease-modifying-antirheumatic-drug-bdmard-therapy-is-associated-with-radiographic-progression-of-large-joint-damage-in-patients-with-rheumatoid-arthritis
#12
Arata Nakajima, Yasuchika Aoki, Keiichiro Terayama, Masato Sonobe, Hiroshi Takahashi, Masahiko Saito, Koichi Nakagawa
OBJECTIVES: Radiographic progression of damage (RPD) to large joints in patients with rheumatoid arthritis (RA) has not been fully studied. We previously demonstrated that Larsen grade of the large joints was associated with RPD of large joints in patients treated with biological disease-modifying anti-rheumatic drugs (bDMARDs); however, no factors associated with background characteristics of patients were identified. METHODS: A total of 400 large joints in the upper and lower extremities, including the shoulder, elbow, knee, and ankle, of 88 patients with RA treated with bDMARDs for 1-3 years were investigated...
March 8, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28271915/a-new-multiplex-real-time-polymerase-chain-reaction-assay-for-the-diagnosis-of-periprosthetic-joint-infection
#13
Masaki Kawamura, Naomi Kobayashi, Yutaka Inaba, Hyonmin Choe, Taro Tezuka, So Kubota, Tomoyuki Saito
OBJECTIVES: A new multiplex real-time polymerase chain reaction (PCR) assay was developed to detect methicillin-resistant Staphylococcus (MRS) and to distinguish between gram-positive and gram-negative bacteria. In this study, we validated the sensitivity and specificity of this assay with periprosthetic joint infections (PJIs) and evaluated the utility of PCR for culture-negative PJI. METHODS: Forty-five samples from 23 infectious PJI cases and 106 samples from 64 non-infectious control cases were analyzed by real-time PCR using a LightCycler Nano(®) system...
March 8, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28269999/baseline-mri-bone-erosion-predicts-the-subsequent-radiographic-progression-in-early-rheumatoid-arthritis-patients-who-achieved-sustained-good-clinical-response
#14
Mami Tamai, Kazuhiko Arima, Yoshikazu Nakashima, Junko Kita, Masataka Umeda, Shoichi Fukui, Ayako Nishino, Takahisa Suzuki, Yoshiro Horai, Akitomo Okada, Tomohiro Koga, Shin-Ya Kawashiri, Naoki Iwamoto, Kunihiro Ichinose, Satoshi Yamasaki, Hideki Nakamura, Tomoki Origuchi, Kiyoshi Aoyagi, Masataka Uetani, Katsumi Eguchi, Atsushi Kawakami
OBJECTIVE: To examine whether magnetic resonance imaging (MRI) findings at baseline predict radiographic progression in early-stage rheumatoid arthritis (RA) patients who have achieved sustained good clinical response. METHODS: This is a sub-analysis from the one-year observational study of Nagasaki University Early Arthritis Cohort. Definition of 'good clinical response' was a decrement of disease activity score (DAS) 28 ≧ 1.2 at three months with achievement of DAS28 remission through 6-12 months...
March 8, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28332887/erratum
#15
(no author information available yet)
No abstract text is available yet for this article.
February 21, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28165852/current-approach-to-the-diagnosis-of-igg4-related-disease-combination-of-comprehensive-diagnostic-and-organ-specific-criteria
#16
Hisanori Umehara, Kazuichi Okazaki, Takuji Nakamura, Tomomi Satoh-Nakamura, Akio Nakajima, Mitsuhiro Kawano, Tsuneyo Mimori, Tsutomu Chiba
IgG4-related disease (IgG4-RD) is a fascinating clinical entity proposed by Japanese investigators, and includes a wide variety of diseases, formerly diagnosed as Mikulicz's disease (MD), autoimmune pancreatitis (AIP), interstitial nephritis, prostatitis, retroperitoneal fibrosis, etc. Although all clinicians in every field of medicine may encounter this new disease, a unifying diagnostic criteria has not been established. In 2011, the Japanese IgG4 team, organized by the Ministry of Health, Labor and Welfare (MHLW) of Japan, published comprehensive diagnostic criteria for IgG4-RD...
February 6, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28165841/survey-of-attitudes-of-non-pediatric-rheumatologists-among-councilors-of-the-japan-college-of-rheumatology-regarding-transitional-care
#17
Takako Miyamae, Syuji Takei, Yasuhiko Itoh, Hisashi Yamanaka
Objectives The transition from pediatric to adult healthcare systems has recently received worldwide attention. Surveys of the attitudes of Japanese non-pediatric rheumatologists regarding transitional care were conducted. Methods Non-pediatric rheumatologists among councilors of the Japan College of Rheumatology were enrolled in the surveys. Experiences of adult patients with childhood-onset rheumatic diseases, ideal medical care for these patients, and factors that made the transition to adult care difficult were examined via e-mail...
February 6, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28165838/microarray-analysis-of-circulating-micrornas-in-familial-mediterranean-fever
#18
Taizo Wada, Tomoko Toma, Yusuke Matsuda, Akihiro Yachie, Saori Itami, Yoshihiro Taguchi, Yoshiki Murakami
OBJECTIVES: Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by mutations in MEFV. Mutations in exon 10 are associated with typical FMF phenotypes, whereas the pathogenic role of variants in exons 2 and 3 remains uncertain. Recent evidence suggests that circulating microRNAs are potentially useful biomarkers in several diseases. Therefore, their expression was assessed in FMF. METHODS: The subjects were 24 patients with FMF who were between attacks: 8 with exon 10 mutations (group A), 8 with exon 3 mutations (group B), and 8 without exon 3 or 10 mutations (group C)...
February 6, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28151032/the-frequency-of-the-celiac-disease-among-children-with-familial-mediterranean-fever
#19
Yasin Sahin, Amra Adrovic, Kenan Barut, Tufan Kutlu, Fugen Cullu-Cokugras, Sezgin Sahin, Ozgur Kasapcopur, Tulay Erkan
OBJECTIVES: We aimed to assess the frequency of celiac disease (CD) in patients with Familial Mediterranean Fever (FMF). METHODS: This is a prospective study was carried out from October 2015 to March 2016. A total of 303 patients with FMF were included. We used 98 sex- and age-matched healthy subjects as a control group. Levels of total IgA and tissue transglutaminase (tTG) IgA antibody were measured in all groups. Those with increased level of tTG IgA were tested for anti-endomysium IgA antibodies (EMA)...
February 2, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28150518/chloroquine-attenuates-tlr3-ifn-%C3%AE-signaling-in-cultured-normal-human-mesangial-cells-a-possible-protective-effect-against-renal-damage-in-lupus-nephritis
#20
Tadaatsu Imaizumi, Ryo Hayakari, Tomoh Matsumiya, Hidemi Yoshida, Kazushi Tsuruga, Shojiro Watanabe, Shogo Kawaguchi, Hiroshi Tanaka
BACKGROUND: Chloroquine has been reported to protect against renal damage in lupus nephritis (LN), however, its detailed mechanism in glomerular inflammation remains unclear. Upregulation of the type I interferon (IFN) system plays a pivotal role in LN pathogenesis, therefore, we examined whether chloroquine inhibits Toll-like receptor 3 (TLR3)/IFN-β signaling in cultured normal human mesangial cells (MCs). METHODS: We examined chloroquine effect on the representative TLR3/IFN-β signaling axis, TLR3/IFN-β/retinoic acid-inducible gene-I (RIG-I)/CCL5 in MCs treated with polyinosinic-polycytidylic acid (poly IC), a synthetic viral dsRNA analog and analyzed the expression of these molecules using reverse transcriptase-polymerase chain reaction and enzyme-linked immunosorbent assay...
February 2, 2017: Modern Rheumatology
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