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Modern Rheumatology

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https://www.readbyqxmd.com/read/30605041/age-and-quality-of-life-in-patients-with-rheumatoid-arthritis-treated-with-biologic-agents
#1
Nao Oguro, Nobuyuki Yajima, Yusuke Miwa
OBJECTIVES: This study aimed to assess the relationship between age and quality of life (QOL) in patients with rheumatoid arthritis (RA) after treatment with biologic agents. METHODS: We recruited 153 patients with RA treated with biologic agents at three hospitals of Showa University from 2005 to 2016 for this retrospective cohort study. Patients were divided into two groups-aged 65 years and older (elderly group) and aged under 65 years (adult group). The primary outcome was the change in QOL over 6 months...
January 3, 2019: Modern Rheumatology
https://www.readbyqxmd.com/read/30605008/neutrophil-lymphocyte-ratio-in-patients-with-ankylosing-spondylitis-a-systematic-review-and-meta-analysis
#2
Shanshan Xu, Yubo Ma, Meng Wu, Xu Zhang, Jiajia Yang, Jixiang Deng, Shiyang Guan, Xing Gao, Shengqian Xu, Zongwen Shuai, Shihe Guan, Liwen Chen, Faming Pan
OBJECTIVE: The aim of this meta-analysis was to investigate the association of neutrophil lymphocyte ratio (NLR) with AS (ankylosing spondylitis) patients. METHODS: PubMed, Web of Science, Cochrane Library, Elsevier Science Direct and Google Scholar databases (up to 30 Sep, 2018) were searched to collect all pertinent articles. The pooled standard mean difference(SMD) with 95% confidence interval (CI) was calculated by the random effects model. RESULTS: Totally ten studies contained 765 AS patients and 701 healthy controls were included in our meta-analysis...
January 3, 2019: Modern Rheumatology
https://www.readbyqxmd.com/read/30582388/italian-consensus-recommendations-for-the-management-of-hepatitis-c-infection-in-patients-with-rheumatoid-arthritis
#3
Marco Sebastiani, Laura Milazzo, Fabiola Atzeni, Caterina Vacchi, Andreina Manfredi, Luca Quartuccio, Carlo Scirè, Giovanni Battista Gaeta, Giovanni Lapadula, Orlando Armignacco, Marcello Tavio, Salvatore D'Angelo, Pierluigi Meroni, Laura Bazzichi, Walter Grassi, Alessandro Mathieu, Claudio Mastroianni, Evangelista Sagnelli, Teresa Santantonio, Caterina Uberti Foppa, Massimo Puoti, Loredana Sarmati, Paolo Airò, Oscar Massimiliano Epis, Rossana Scrivo, Miriam Gargiulo, Agostino Riva, Giovanni Ciancio, Gianguglielmo Zehender, Gloria Taliani, Luca Meroni, Salvatore Sollima, Piercarlo Sarzi-Puttini, Massimo Galli
OBJECTIVES: The recent itroduction of direct-acting antiviral agents (DAAs) which can eliminate Hepatitis C virus (HCV) had revoluzionized the treatment of HCV infections also in a complex clinical setting such as the patients with rheumatoid arthritis (RA). HCV elimination is also opportune due to the availability of more efficient immunosuppressive drugs, whose effect on the course of HCV infection is largely unknown. METHODS: Consensus process was endorsed by the Italian Society of Rheumatology (SIR) and the Italian Society of Infectious and Tropical Diseases (SIMIT) to review the available evidences and produce practical, hospital-wide recommendations...
December 22, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/30572779/age-at-the-time-of-hip-fracture-in-patients-with-rheumatoid-arthritis-is-4-years-greater-than-it-was-10-years-previously-but-is-still-younger-than-that-of-the-general-population
#4
Katsumitsu Arai, Nobuaki Suzuki, Takayuki Murayama, Naoki Kondo, Hiroshi Otsuka, Masahiro Koizumi, Noboru Hosaka, Ryuta Fujikawa, Kazuhito Yanabashi, Yosuke Sasage, Ken Yoshida, Keishi Kimura, Kentaroh Higuchi, Junya Ajiro, Naoto Endo
OBJECTIVE: To investigate the characteristics of hip fractures in patients with rheumatoid arthritis (RA). METHODS: Between 2012 and 2015, 789 hip fractures were treated at our hospital. Patients with RA were checked and their characteristics were compared with data recorded 10 years previously, and with the general population. RESULTS: There were eleven patients with RA, who were all female, and the mean age was 76 ± 7.0 years. The age at the time of hip fracture was 4 years older than that recorded 10 years previously (72 ± 4...
December 20, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/30565491/treatment-consensus-for-management-of-polymyositis-and-dermatomyositis-among-rheumatologists-neurologists-and-dermatologists
#5
Hitoshi Kohsaka, Tsuneyo Mimori, Takashi Kanda, Jun Shimizu, Yoshihide Sunada, Manabu Fujimoto, Yasushi Kawaguchi, Masatoshi Jinnin, Yoshinao Muro, Shoichiro Ishihara, Hiroyuki Tomimitsu, Akiko Ohta, Takayuki Sumida
Although rheumatologists, neurologists and dermatologists see patients with polymyositis (PM) and dermatomyositis (DM), their management appears to vary depending on the physician's specialty. The aim of the present study was to establish the treatment consensus among specialists of the three fields to standardize the patient care. We formed a research team supported by a grant from the Ministry of Health, Labor and Welfare, Japan. Clinical questions (CQ) on the management of PM and DM were raised. A published work search on CQ was performed primarily using PubMed...
December 19, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/30561239/associated-factors-with-adherence-to-standard-exercise-therapy-and-health-related-quality-of-life-in-chinese-patients-with-ankylosing-spondylitis
#6
Yan Sang, Chen Dong, Ting Fu, Rui Zhao, Xingyu Ge, Wei Zhou, Juan Ji, Zhifeng Gu
OBJECTIVES: The aim of this study is to assess the current situations of standard exercise treatment and predictors of non-standard exercise in Chinese patients with ankylosing spondylitis (AS). An analysis of the effect of standard exercise on health-related quality of life (HR-QoL) was also conducted. METHODS: In the cross-sectional study, a total of 259 AS patients were constantly invited to participate in this study and complete the questionnaire under the researchers' supervision in a clinical setting including sociodemographic variables, clinical variables, psychological variables and HR-QoL...
December 18, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/30561237/the-benefits-and-prospects-of-interleukin-6-inhibitor-on-systemic-sclerosis
#7
Yoshihito Shima
Systemic sclerosis (SSc) is a connective tissue disease, the pathogenesis of which is thought to involve interleukin-6 (IL-6), an inflammatory cytokine. This is based on findings of its concentration in patient serum, the results of an IL-6 suppression experiment in an animal model, and the results of a pilot study using IL-6 receptor antibody. However, it appears that a number of factors are involved in the pathology of SSc depending on the state of disease progression. In addition, the degree of involvement of IL-6 is differ depending on the difference of organs with in particular severe symptoms...
December 18, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/30558516/-il-6-is-a-treatment-target-for-a-variety-of-immune-diseases-the-benefit-and-prospect-of-il-6-inhibitor
#8
Yutaka Kawahito
No abstract text is available yet for this article.
December 18, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/30557100/potential-therapeutics-for-antiphospholipid-antibody-associated-thrombocytopenia-a-systematic-review-and-meta-analysis
#9
Nobuya Abe, Kenji Oku, Olga Amengual, Yuichiro Fujieda, Masaru Kato, Toshiyuki Bohgaki, Shinsuke Yasuda, Rintaro Mori, Eriko Morishita, Katsue Suzuki-Inoue, Tatsuya Atsumi
OBJECTIVES: Thrombocytopenia is frequently observed in antiphospholipid antibody (aPL) carriers. Due to the paradoxical risks of thrombosis and hemorrhage, the management of aPL-associated thrombocytopenia (APAT) is often deductive. We aimed to investigate the efficacy and safety of therapeutic approaches for APAT through a systematic review. METHODS: Four therapeutic approaches for APAT, including antiplatelet agents, glucocorticoids, splenectomy and thrombopoietin receptor agonists, were selected...
December 17, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/30557067/the-front-line-of-research-into-immunoglobin-ig-g4-related-disease-do-autoantibodies-cause-igg4-rd
#10
Hisanori Umehara, Kazuichi Okazaki, Mitsuhiro Kawano, Yoshiya Tanaka
IgG4-related disease (IgG4-RD) is a novel clinical disease entity characterized by elevated serum IgG4 concentration and tumefaction or tissue infiltration by IgG4-positive plasma cells. Although IgG4-RD is attracting strong attention as a new clinical entity, the pathogenesis of IgG4-RD and the roles of IgG4 are still unknown. Recently, self-antigens including Laminin 511 E8, Galectin-3 and Annexin A11, have been reported from one to the next as autoantigens which may be involved in the pathogenesis of IgG4-RD...
December 17, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/30557064/behcet-s-disease-in-iran-analysis-of-7641-cases
#11
Fereydoun Davatchi, Farhad Shahram, Cheyda Chams-Davatchi, Hormoz Shams, Bahar Sadeghi Abdolahi, Abdolhadi Nadji, Tahereh Faezi, Massoomeh Akhlaghi, Zahra Ghodsi, Nooshin Karimi, Hoda Kavosi, Negin Mohtasham, Maryam Masoumi, Soraya Shadmanfar, Mohammad Mousavi
OBJECTIVE: To analyze Behcet's Disease (BD) in Iran, from 1975 to 2018, and compare to 35 large/small reports from other countries. METHODS: Patients from all over Iran, when suspected, were sent to the BD Unit. The diagnosis was done by expert opinion. All data were recorded in the BD registry (updated in each follow-up). The data are given in percentage with 95% confidence Intervals. RESULTS: The mean age at onset was 25.6 years. Standard Deviation (SD) was 9...
December 17, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/30557058/remission-of-proteinuria-under-therapeutic-intervention-and-the-renal-outcomes-in-japanese-patients-with-lupus-nephritis-class-iii-and-iv
#12
Yusuke Okabayashi, Nobuo Tsuboi, Kotaro Haruhara, Go Kanzaki, Kentaro Koike, Yoichi Miyazaki, Tetsuya Kawamura, Makoto Ogura, Takashi Yokoo
BACKGROUND: Recent studies have identified the significance of proteinuria levels after initial induction therapies on the renal outcomes in patients with proliferative lupus nephritis, but the issue has not been evaluated in Japanese patients. METHODS: Based on the ISN/RPS classification, only patients diagnosed as lupus nephritis class III or IV were included. The remission of proteinuria twelve months after diagnosis, as well as the clinicopathological features at diagnosis, on renal outcomes was examined retrospectively...
December 17, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/30557057/fibrosis-4-index-at-diagnosis-can-predict-all-cause-mortality-in-patients-with-rheumatoid-arthritis-a-retrospective-monocentric-study
#13
Seung Up Kim, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Yong-Beom Park, Kwang-Hyub Han, Sang-Won Lee
Objectives Comorbidities and conventional risk factors influence the prognosis of patients with rheumatoid arthritis (RA). We investigated whether liver fibrosis burden is associated with all-cause mortality in patients with RA. Methods A total of 2812 patients with RA were retrospectively selected and reviewed. Liver fibrosis was assessed using the fibrosis-4 index (FIB-4) [age (years)× aspartate aminotransferase level (IU/L)/platelet count (109 /L)/√alanine aminotransferase (IU/L)]. Results The mean patient age was 51...
December 17, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/30556788/long-term-hip-survival-and-factors-influencing-patient-reported-outcomes-after-transtrochanteric-anterior-rotational-osteotomy-for-osteonecrosis-of-the-femoral-head-a-minimum-10-year-follow-up-case-series
#14
Koichiro Kawano, Goro Motomura, Satoshi Ikemura, Yusuke Kubo, Junichi Fukushi, Satoshi Hamai, Masanori Fujii, Yasuharu Nakashima
OBJECTIVES: This retrospective study aimed to assess long-term hip survival after transtrochanteric anterior rotational osteotomy (ARO) for osteonecrosis of the femoral head (ONFH) and identify factors influencing patient-reported outcome measures (PROMs) in patients with preserved joints. METHODS: Altogether, 95 consecutive hips in 85 ONFH patients who underwent ARO during 2000-2007 (86.7% follow-up) were studied. Controls were 35 patients with 41 hips with ONFH managed conservatively for >1 year after collapse...
December 17, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/30556769/long-term-effect%C3%A4-veness-and-safety-of-canak%C3%A4-numab-%C3%A4-n-ped%C3%A4-atr%C3%A4-c-fam%C3%A4-l%C3%A4-al-med%C3%A4-terranean-fever-pat%C3%A4-ents
#15
Nesrin Gülez, Balahan Makay, Betül Sözeri
BACKGROUND: Little is known about the long-term efficacy and safety of canakinumab in paediatric FMF patients. AIM: To present the single centre experience of colchicine-resistant paediatric-onset FMF patients who were treated with canakinumab by off-label use since 2012. METHODS: The hospital files of 15 children who used canakinumab were retrospectively evaluated. Clinical and laboratory data of each visit were recorded. Drug-related adverse events were recorded...
December 17, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/30501428/locomotive-syndrome-testing-in-young-and-middle-adulthood
#16
Akinobu Nishimura, Makoto Ohtsuki, Toshihiro Kato, Eri Nagao, Naoya Ito, Ko Kato, Toru Ogura, Akihiro Sudo
Background Previous epidemiological studies on locomotive syndrome (LS) have been mainly conducted in retired elderly people. However, from the view point of its prevention, it is important to assess currently-working younger people. The purpose of this study was to examine the status of the level of LS in young and middle-aged adult workers. Methods This cross-sectional study was performed at four companies. We used the two-step test, stand-up test, and 25-question Geriatric Locomotive Function Scale (GLFS-25) as screening tools of LS...
December 3, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/30499730/igg4-related-kidney-disease-and-retroperitoneal-fibrosis-an-update
#17
Mitsuhiro Kawano, Takako Saeki, Hitoshi Nakashima
The most representative kidney lesion of IgG4-related disease (IgG4-RD) is plasma cell-rich tubulointerstitial nephritis (TIN) with distinctive imaging findings including multiple low-density lesions on contrast-enhanced computed tomography. In addition, membranous glomerulonephritis is a representative glomerular lesion of this disease. Recent advances have clarified that inflammation with IgG4-positive plasma cell infiltrates is not restricted to the renal parenchyma, but can be seen in outside the renal capsule, around medium-sized arteries such as lobar arteries, around nerves, and in the renal pelvis and periureter...
November 30, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/30499364/disease-activity-treatment-and-long-term-prognosis-of-adult-juvenile-idiopathic-arthritis-patients-compared-with-rheumatoid-arthritis-patients
#18
Takumi Matsumoto, Toshihiro Matsui, Fumio Hirano, Shigeto Tohma, Masaaki Mori
OBJECTIVE: To evaluate the difference between adult juvenile idiopathic arthritis (JIA, starting at <16 years) and rheumatoid arthritis (RA) . METHODS: Data on 128 adult JIA patients were from the National Database of Rheumatic Diseases in Japan (NinJa), 2014, divided into 4 groups by period of disease onset (Group 1: 2000-2013, n = 32; Group 2: 1981-1999, n = 32; Group 3: 1966-1980, n = 31; Group 4: ∼1965, n = 33). Disease activity, treatment and long-term prognosis of adult JIA patients was compared with RA patients matched for sex- and disease duration in each era...
November 30, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/30489177/efficacy-and-safety-of-tofacitinib-in-japanese-patients-with-rheumatoid-arthritis-by-background-methotrexate-dose-a-post-hoc-analysis-of-clinical-trial-data
#19
Tsutomu Takeuchi, Hisashi Yamanaka, Kunihiro Yamaoka, Shoko Arai, Shigeyuki Toyoizumi, Ryan DeMasi, Yuri Fukuma, Tomohiro Hirose, Naonobu Sugiyama, Samuel H Zwillich, Yoshiya Tanaka
OBJECTIVES: Tofacitinib is an oral JAK inhibitor for the treatment of rheumatoid arthritis (RA). We investigated concomitant methotrexate (MTX) dose on tofacitinib efficacy/safety in Japanese RA patients. METHODS: This post-hoc analysis pooled data from a 3-month Phase 2 study (NCT00603512) and a 24-month Phase 3 study (NCT00847613). Patients (N = 254) received tofacitinib (low-dose [1 or 3 mg], 5 mg, 10 mg) twice daily (BID) or placebo, with low-dose (>0-≤8 mg/week) or high-dose (>8 mg/week) MTX...
November 29, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/30486712/suppression-of-hematopoietic-cell-kinase-ameliorates-the-bone-destruction-associated-with-inflammation
#20
Yusoon Kim, Mikihito Hayashi, Takehito Ono, Tetsuya Yoda, Hiroshi Takayanagi, Tomoki Nakashima
OBJECTIVES: To investigate the role of non-receptor tyrosine kinases (NRTKs) in inflammation-induced osteoclastogenesis. METHODS: Microarray analyses of global mRNA expression during receptor activator of NF-κB ligand (RANKL) and RANKL plus tumor necrosis factor (TNF)-α-induced osteoclast differentiation were performed. The inhibitory effect on TNF-α-induced osteoclast differentiation of A-419259, a potent inhibitor of hematopoietic cell kinase (Hck), was examined...
November 28, 2018: Modern Rheumatology
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