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Modern Rheumatology

Shigeto Kobayashi, Tomoko Kashiwagi, Junko Kimura
OBJECTIVE: To evaluate the real-world effectiveness and safety of adalimumab for the treatment of ankylosing spondylitis (AS) in Japan. METHODS: All AS patients initiated on adalimumab from October 27, 2010, to May 28, 2015, were enrolled. Patient characteristics at baseline, changes in Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) scores, and adverse drug reactions (ADRs) for 24 weeks from the first adalimumab treatment were evaluated. RESULTS: Of 403 enrolled patients, 396 and 374 comprised the safety and effectiveness analysis sets, respectively...
September 15, 2018: Modern Rheumatology
He-Xiang Zong, Sheng-Qian Xu, Hui Tong, Xin-Rong Wang, Mei-Juan Pan, Yu-Zhu Teng
BACKGROUND: Efficacy of anti-tumor necrosis factor (anti-TNF)α treatment in patient with active ankylosing spondylitis (AS) had been proved by many clinical studies. Inflammation and new bone formation in spine were two pivotal aspects in AS. TNF α inhibitor could eliminate inflammation including clinical and laboratory inflammatory manifestation. Paradoxical results whether TNF α antagonist could delay radiographic progression in AS were often been reported simultaneously. OBJECTIVES: To review literature about effect of TNF α inhibitor on radiographic progression and disease activity in patient with AS...
September 15, 2018: Modern Rheumatology
Nobunori Takahashi, Toshihisa Kojima, Daihei Kida, Atsushi Kaneko, Yuji Hirano, Takayoshi Fujibayashi, Yuichiro Yabe, Hideki Takagi, Takeshi Oguchi, Masahiro Hanabayashi, Takefumi Kato, Koji Funahashi, Masatoshi Hayashi, Seiji Tsuboi, Yasuhide Kanayama, Yasumori Sobue, Nobuyuki Asai, Takuya Matsumoto, Tatsuo Watanabe, Shuji Asai, Naoki Ishiguro
OBJECTIVE: To study the clinical effectiveness and long-term retention rate of abatacept (ABA) in elderly rheumatoid arthritis (RA) patients in daily clinical practice. METHODS: A retrospective cohort study was performed using data from a multicenter registry. Our study population comprised 500 consecutive RA patients treated with ABA. We compared clinical effectiveness and ABA retention rates between the Young (≤ 62 years), Middle (62 to 72 years), and Elderly (≥ 72 years) groups...
September 15, 2018: Modern Rheumatology
Akihiro Moritake, Naoyuki Kawao, Kiyotaka Okada, Masayoshi Ishida, Kohei Tatsumi, Osamu Matsuo, Masao Akagi, Hiroshi Kaji
OBJECTIVES: Interleukin (IL)-1β and matrix metalloproteinases (MMPs) play important roles in the pathogenesis of osteoarthritis. On the other hand, plasminogen activator inhibitor-1 (PAI-1), an inhibitor of fibrinolysis, exerts functions in the pathogenesis of various diseases. However, the functional roles of PAI-1 in the chondrocytes have been still remained unknown. METHODS: In the present study, we investigated the roles of PAI-1 in the effects of IL-1β on the chondrocytes using wild-type and PAI-1-deficient mice...
September 15, 2018: Modern Rheumatology
Yohei Yukizawa, Yutaka Inaba, Naomi Kobayashi, So Kubota, Tomoyuki Saito
OBJECTIVE: A history of venous thromboembolism (VTE) is a risk factor for newly formed VTE after total hip arthroplasty (THA). However, its morbidity and association with postoperative VTE are not clear and, therefore, were investigated in this study. METHODS: Four hundreds and nineteen patients scheduled for primary THA were included. We preoperatively identified any VTE factors such as obesity, age, and history of VTE by interviewing and duplex ultrasonography for all patients, and the patients were assigned into "high- "or "low-risk" groups, that were the indication whether chemoprophylaxis was administered after surgery...
September 14, 2018: Modern Rheumatology
Ahmet Şükrü Aynacıoğlu, Ayhan Bilir, Mehmet Yakup Tuna
Midkine (MK) is a heparin-binding growth factor that markedly expressed during embryogenesis but downregulated to inconsiderable levels in healthy adults. However, MK is upregulated during tissue repair and in many pathologic conditions, mostly malignancies and inflammatory diseases. MK promotes a number of functions in target cells such as migration, proliferation, survival, growth, reproduction and repair, angiogenesis and gene expression. It acts as a pro-inflammatory cytokine and contributes to chronic inflammation via promoting chemotaxis and tissue infiltration of neutrophils and macrophages...
September 14, 2018: Modern Rheumatology
Takako Suzuki, Yukio Nakamura, Hiroyuki Kato
Purpose/Introduction: This extended randomized prospective study aimed to compare the 4-year clinical outcomes of denosumab treatment alone or in combination with teriparatide in treatment-naïve postmenopausal Japanese patients with osteoporosis. METHODS: Between July 2013 and December 2016, 30 eligible women from our previous study were enrolled. After newly adding 17 randomly assigned patients, 47 patients were classified into the denosumab alone group (denosumab group, n = 22) or denosumab plus teriparatide group (combination group, n = 25)...
September 14, 2018: Modern Rheumatology
Masayoshi Harigai, Naoki Ishiguro, Shigeko Inokuma, Tsuneyo Mimori, Junnosuke Ryu, Syuji Takei, Tsutomu Takeuchi, Yoshiya Tanaka, Yoshinari Takasaki, Hisashi Yamanaka, Yuri Yoshizawa, Ichino Chinen, Toru Nakao, Takao Koike
OBJECTIVES: To investigate safety, effectiveness, and risk-benefit balance of intravenous abatacept (ABA) in non-elderly (<65 years: NEG) and elderly (≥65 years: EG) rheumatoid arthritis patients. METHODS: This sub-analysis of an all-cases postmarketing surveillance in Japan assessed safety in all enrolled patients and effectiveness in those with Disease Activity Score 28 based on C-reactive protein (DAS28-CRP) measurements at ≥2 time points including baseline...
September 14, 2018: Modern Rheumatology
Chiara Posarelli, Rosaria Talarico, Andrea Passani, Marta Mosca, Marco Nardi, Michele Figus
No abstract text is available yet for this article.
September 13, 2018: Modern Rheumatology
Mie Torii, Motomu Hashimoto, Akiko Hanai, Takao Fujii, Moritoshi Furu, Hiromu Ito, Ryuji Uozumi, Masahide Hamaguchi, Chikashi Terao, Wataru Yamamoto, Miyabi Uda, Kazuko Nin, Satoshi Morita, Hidenori Arai, Tsuneyo Mimori
OBJECTIVES: Sarcopenia is characterized by loss of muscle strength and mass, leading to falls and adverse health outcomes. Our aim was to determine the prevalence of sarcopenia in patients with rheumatoid arthritis (RA) and to identify factors associated with sarcopenia in these patients. METHODS: A cross-sectional study of 388 consecutive women with RA was conducted, assessing muscle mass and strength, and walking speed. Falls and bone fractures sustained over the prior year were evaluated...
September 11, 2018: Modern Rheumatology
Yoshiya Tanaka, Tsuneyo Mimori, Hisashi Yamanaka, Ryo Nakajima, Kazuo Morita, Junko Kimura, Tsutomu Takeuchi
OBJECTIVES: This real-world study assessed the effectiveness and safety outcomes of initiating adalimumab and methotrexate (≥12 mg/week) with adjustable dosing in Japanese patients with early rheumatoid arthritis (RA). METHODS: This single-arm, prospective postmarketing observational study (conducted from September 2012 to March 2017 at 119 sites) enrolled biologic-naïve patients with early RA (≤2 years duration) and a Disease Activity Score in 28 joints using C-reactive protein (DAS28-CRP) >3...
September 11, 2018: Modern Rheumatology
Naomi Iwata, Haruna Nakaseko, Toaki Kohagura, Ryuhei Yasuoka, Naoki Abe, Shinji Kawabe, Shiro Sugiura, Yoshinao Muro
OBJECTIVES: This study investigated the association between myositis-specific autoantibodies (MSAs) and clinical subsets of juvenile dermatomyositis (JDM) in Japanese patients. METHODS: Twenty-one patients at a single center who developed initial or relapsed JDM from 2011 to 2016 were analyzed. Serum concentrations of MSAs against TIF1-γ, MDA5, NXP2, Mi-2, ARS, and SAE were measured by enzyme-linked immunosorbent assays. Clinical symptoms and laboratory data were obtained from clinical records...
September 10, 2018: Modern Rheumatology
Joon-Yong Jung, Seung Hee Han, Yeon Sik Hong, Sung-Hwan Park, Ji Hyeon Ju, Kwi Young Kang
OBJECTIVE: To determine the association between inflammatory lesions on spinal magnetic resonance imaging (MRI) and trabecular bone score (TBS) in patients with ankylosing spondylitis (AS). METHODS: Ninety-seven patients with AS underwent spine MRI and dual energy X-ray absorptiometry of the lumbar spine to measure TBS and bone mineral density (BMD). Bone marrow edema (BME) on MRI was considered an inflammatory lesion. The presence, depth (>1 cm), and intensity of BME on MRI were scored for the 1st-4th lumbar spine segments...
September 10, 2018: Modern Rheumatology
Masayoshi Harigai, Kenji Nagasaka, Koichi Amano, Masashi Bando, Hiroaki Dobashi, Tamihiro Kawakami, Kan Kishibe, Yohko Murakawa, Joichi Usui, Takashi Wada, Eiichi Tanaka, Eishu Nango, Takeo Nakayama, Michi Tsutsumino, Kunihiro Yamagata, Sakae Homma, Yoshihiro Arimua
OBJECTIVE: The Japan Research Committee for Intractable Vasculitis has fully revised the clinical practice guidelines (CPG) for the management of antineutrophil cytoplasmic antibody-associated vasculitis (AAV) to improve and standardize the medical treatment of the disease in Japan. METHODS: The previous CPG was published in a classical review style in Japanese in 2011 and 2014. We adopted the Grading of Recommendations Assessment, Development and Evaluation system for this revision, and various stakeholders, including patients, participated in it...
September 10, 2018: Modern Rheumatology
Tetsuya Furukawa, Kiyoshi Matsui, Masayasu Kitano, Yuichi Yokoyama, Masahiro Sekiguchi, Naoto Azuma, Yasutomo Imai, Seiichi Hirota, Kiyofumi Yamanishi, Hajime Sano
OBJECTIVES: Systemic sclerosis (SSc) is an intractable connective tissue disease that causes skin and organ fibrosis. Interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH) affect its prognosis. YKL-40 protein impacts inflammation and tissue remodeling. Therefore, we evaluated the utility of YKL-40 blood levels in identifying patients with SSc complicated by PAH, as confirmed by immunohistochemistry (IHC) examination. METHODS: We retrospectively analyzed 78 patients with SSc and performed IHC on 7 normal and 7 SSc skin samples in the Japanese population...
September 6, 2018: Modern Rheumatology
Shuo Zhang, Chen Li, Siya Zhang, Li Li, Weihong Zhang, Zhenhua Dong, Wen Zhang
OBJECTIVE: To measure the expression of proinflammatory, anti-inflammatory cytokines, and receptor activator NK-κB ligand (RANKL)/osteoprotegerin (OPG) in synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome, and to assess the relationship between those factors and disease activity. METHODS: We studied 30 cases of SAPHO syndrome and 15 healthy controls. According to the Visual Analogue Scale (VAS) pain scores and Bath Ankylosing Spondylitis Activity Index (BASDAI), patients were divided into active group and stable group...
September 6, 2018: Modern Rheumatology
Tomohiko Yoshida, Yasuhiro Otaki, Naooki Katsuyama, Michiko Seki, Junko Kubota
OBJECTIVES: We aimed to evaluate the effect of change to the existing formulation of adalimumab (ADA) on pain and treatment motivation. METHODS: We classified injection pain into the following categories: overall pain, pain at needle insertion, pain during drug injection, and pain 10 min after injection; we evaluated the effect of change to the existing formulation on pain using a visual analog scale. In addition, a faces pain scale was used to evaluate the effect of change in injection pain intensity on treatment motivation...
September 5, 2018: Modern Rheumatology
Masataka Torigoe, Keisuke Maeshima, Takashi Ozaki, Yuichi Omura, Koro Gotoh, Yoshiya Tanaka, Koji Ishii, Hirotaka Shibata
OBJECTIVES: Increasing evidence has revealed the close correlation between immune cell functions and their intracellular metabolism. Mammalian target of rapamycin complex 1 (mTORC1) is the important metabolism-modulating signal that regulates cellular activities. In certain types of cell, it is known that mTORC1 activation depends on influx of l-leucine through an amino acid transporter, Slc7a5. In B cells, however, the expression and the role of Slc7a5 have never been investigated. METHODS: CD19+ B cells were obtained from peripheral blood of healthy adults and stimulated by a toll-like receptor 9 ligand, CpG oligodeoxynucleotides...
September 5, 2018: Modern Rheumatology
Yoshihiko Kawano, Jun-Ichi Kawada, Noriko Nagai, Yoshinori Ito
OBJECTIVES: Kawasaki disease (KD) is one of the most common childhood vasculitides. Some serological studies have suggested an etiological relationship between KD and human herpesvirus (HHV)-6 or HHV-7. However, primary or reactivated HHV-6 and -7 has not been fully investigated in patients with KD. METHODS: Twenty-three patients with KD were prospectively enrolled in this study. Peripheral blood was collected in the acute and convalescence phases, and HHV-6 and -7 viral loads were measured by real-time PCR...
September 5, 2018: Modern Rheumatology
Yoshiyuki Arinuma, Hirotoshi Kikuchi, Shunsei Hirohata
OBJECTIVES: The aim of this study is to clarify the effect of various autoantibodies on overall mortality in patients with diffuse psychiatric/neuropsychological syndromes in SLE (diffuse NPSLE). METHODS: Fifty-five patients with diffuse NPSLE admitted from 1992 to 2017 had met inclusion criteria and were recruited for this study. The relationship of various serum autoantibodies with mortality was retrospectively analyzed based on the medical charts. RESULTS: Of 55 patients, 14 patients [25...
September 5, 2018: Modern Rheumatology
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