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Modern Rheumatology

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https://www.readbyqxmd.com/read/29671370/synovial-inflammation-analyzed-by-3-t-magnetic-resonance-imaging-in-etanercept-treated-patients-with-rheumatoid-arthritis-indicates-persistent-disease-activity-despite-of-clinical-remission-a-pilot-study
#1
Mara Oleszowsky, Winfried Willinek, Milka Marinova, Matthias F Seidel
OBJECTIVES: To evaluate joint inflammation using 3-T MRI in rheumatoid arthritis (RA) patients treated with conventional disease modifying anti-rheumatic drugs (cDMARDs) as compared to inhibitors for tumor necrosis factor α (TNFi) over 12 months. METHODS: Prospective epidemiologic clinical pilot study using the RA MRI system (RAMRIS), the visual analog scale (VAS, 0-100) and the Disease Activity Score 28-joint count (DAS28) at baseline, 4, and 12 months after initiation of etanercept (ETA)...
May 9, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29651907/evidence-based-clinical-practice-guideline-for-adult-still-s-disease
#2
Toshihide Mimura, Yuya Kondo, Akihide Ohta, Masahiro Iwamoto, Akiko Ota, Nami Okamoto, Yasushi Kawaguchi, Hajime Kono, Yoshinari Takasaki, Shuji Takei, Norihiro Nishimoto, Manabu Fujimoto, Yu Funakubo Asanuma, Akio Mimori, Naoko Okiyama, Shunta Kaneko, Hiroyuki Takahashi, Masahiro Yokosawa, Takayuki Sumida
OBJECTIVES: Using an expert- and data-driven methodology, we have constructed the first clinical practice guidelines (CPGs) for adult Still's disease (ASD) after complete systematic review (SR) of the literature based upon the Medical Information Network Distribution Service (Minds) procedure. METHODS: The CPG committee for ASD organized by the Research Team for Autoimmune Diseases, the Research Program for Intractable Disease of the Japanese Ministry of Health, Labour, and Welfare has developed CPG for ASD 2017, according to the procedure proposed by Minds...
May 9, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29718746/japan-college-of-rheumatology-guideline-for-the-use-of-methotrexate-in-patients-with-rheumatoid-arthritis
#3
Hideto Kameda, Takao Fujii, Ayako Nakajima, Ryuji Koike, Akira Sagawa, Katsuaki Kanbe, Tetsuya Tomita, Masayoshi Harigai, Yasuo Suzuki
Methotrexate (MTX), the anchor drug in the current treatment strategy for rheumatoid arthritis (RA), was first approved for treatment of RA in Japan in 1999 at the recommended dose of 6-8 mg/week; it was approved as first-line drug with the maximum dose of 16 mg/week in February 2011. However, more than half of Japanese patients with RA are unable to tolerate a dose of 16 mg/week of MTX. Moreover, some serious adverse events during the treatment with MTX, such as pneumocystis pneumonia and lymphoproliferative disorders, have been observed much more frequently in Japan than in other countries...
May 2, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29694263/the-decrease-in-phase-angle-measured-by-bioelectrical-impedance-analysis-reflects-the-increased-locomotive-syndrome-risk-in-community-dwelling-people-the-yakumo-study
#4
Satoshi Tanaka, Kei Ando, Kazuyoshi Kobayashi, Tetsuro Hida, Taisuke Seki, Takashi Hamada, Kenyu Ito, Mikito Tsushima, Masayoshi Morozumi, Masaaki Machino, Kyotaro Ota, Naoki Ishiguro, Yukiharu Hasegawa, Shiro Imagama
OBJECTIVES: The locomotive syndrome (LS) risk test has recently been advocated for the evaluation of physical ability. Phase angle measurement by bioelectrical impedance analysis (BIA) is an indicator of cellular health and muscle mass. We aimed to investigate how muscle mass and phase angle are related to LS risk stage. METHODS: A prospective cohort study was conducted in 311 patients who were undergoing a health checkup. All participants performed the two-step test, stand-up test, and 25-question geriatric locomotive function scale components of the LS risk test...
April 25, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29694256/associations-of-circulating-cxcr3-pd-1-cd4-t-cells-with-disease-activity-of-systemic-lupus-erythematosus
#5
Han Lei, Yang Xue, Yu Yiyun, Wan Weiguo, Lv Ling, Hejian Zou
OBJECTIVES: Which helper CD4+ T cell subset contributes to autoantibodies generation and severity of end-organ involvement in lupus patients remains to be explored. Our research aims to investigate the roles of circulating Tfh (cTfh) cell subsets and corresponding CXCR5- Th cells in lupus patients and their correlation with SLEDAI. METHODS: Peripheral blood mononuclear cells (PBMCs) were isolated from blood of SLE patients as well as healthy donors. The proportion of Th cell Subsets classified from cell surface markers (CD45RO, CXCR5, CXCR3, CCR6, PD-1, ICOS, and CCR7) is detected by flow cytometry...
April 25, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29694253/serum-levels-of-proinflammatory-antiinflammatory-cytokines-and-rankl-opg-in-synovitis-acne-pustulosis-hyperostosis-and-osteitis-sapho-syndrome
#6
Shuo Zhang, Chen Li, Siya Zhang, Li Li, Weihong Zhang, Zhenhua Dong, Wen Zhang
Objective To measure the expression of proinflammatory, antiinflammatory cytokines, and RANKL/OPG in SAPHO Syndrome, and to assess the relationship between those factors and disease activity. Methods We studied 30 cases of SAPHO syndrome and 15 healthy controls. According to the visual analogue scale pain scores and Bath ankylosing spondylitis activity index, patients were divided into active group and stable group. The serum levels of IFN-γ, TNF-α, TGF-β1, IL-1β, IL-4, IL-6, IL-8, IL-17A, IL-22, receptor activator NK-κB ligand (RANKL) and osteoprotegerin (OPG) were determined by ELISA...
April 25, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29693466/isoprostane-in-systemic-sclerosis-a-systematic-review-and-meta-analysis
#7
Paul Rj Ames, Mira Merashli, Tommaso Bucci, Jaffar Norouz-Zadeh
OBJECTIVES: to further the knowledge of oxidative stress in systemic sclerosis (SSc) we performed a systematic review and meta-analysis on studies measuring isoprostane, a vasoactive agent deriving from arachidonic acid and implicated in the vasculopathy of SSc. METHODS: systematic search following the PRISMA guidelines in PubMed and EMBASE between January-1990/December-2017 using the terms: oxidative stress, isoprostane, systemic sclerosis, scleroderma. RESULTS: After the screening process 8 studies including 240 SSc patients and 192 controls were included in the systematic review and meta-analysis, 6 investigating urinary and 2 serum isoprostane: random effect meta-analysis revealed isoprostane overgeneration in SSc (p < 0...
April 25, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29669460/current-diagnosis-and-treatment-of-polymyositis-and-dermatomyositis
#8
Hirokazu Sasaki, Hitoshi Kohsaka
Idiopathic inflammatory myopathies (IIMs) are heterogeneous disorders that affect the skeletal muscles. Polymyositis, dermatomyositis, and inclusion body myositis are major IIM subsets. Immune-mediated necrotizing myopathy became recognized as a potentially new IIM subset. Since the new classification criteria published by the International Myositis Classification Criteria Project have higher sensitivity and specificity for IIM classification and subclassification than the previous criteria, they should help precise diagnosis...
April 18, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29669457/sleep-apnea-in-sj%C3%A3-gren-s-syndrome-potentially-influences-the-eular-sj%C3%A3-gren-s-syndrome-patient-reported-index
#9
Maike Jülich, Stephan Budweiser, Jan Thoden, Reinhard E Voll, Florian Kollert
No abstract text is available yet for this article.
April 18, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29667905/essential-role-of-mohawk-for-tenogenic-tissue-homeostasis-including-spinal-disc-and-periodontal-ligament
#10
Ryo Nakamichi, Kensuke Kataoka, Hiroshi Asahara
Tendons and ligaments play essential roles in connecting muscle and bone and stabilizing the connections between bones. The damage to tendons and ligaments caused by aging, injury, and arthritis induces the dysfunction of the musculoskeletal system and reduces the quality of life. Current therapy for damaged tendons and ligaments depends on self-repair; however, it is difficult to reconstruct normal tissue. Regeneration therapy for tendons and ligaments has not been achieved, partly because the mechanism, cell biology, and pathophysiology of tendon and ligament development remain unclear...
April 18, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29667474/long-term-follow-up-of-finger-passive-range-of-motion-in-japanese-systemic-sclerosis-patients-treated-with-self-administered-stretching
#11
Naoki Mugii, Takashi Matsushita, Sachie Oohata, Hirokazu Okita, Tetsutarou Yahata, Fujiko Someya, Minoru Hasegawa, Manabu Fujimoto, Kazuhiko Takehara, Yasuhito Hamaguchi
OBJECTIVE: Severe skin sclerosis in patients with systemic sclerosis (SSc) can result in a loss of hand function. The aim of this study is to examine the long-term changes of finger passive range of motion (ROM) in Japanese SSc patients treated with self-administered stretching. METHODS: This is a single center, retrospective, observational cohort study. Forty-three Japanese patients with SSc were given instructions on self-administered stretching. ROM was assessed using a goniometer on their first visit and after 1 year, 3 years, 5 years, and 9 years...
April 18, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29542383/predisposition-of-six-well-characterized-micrornas-to-syndesmophytes-among-chinese-patients-with-ankylosing-spondylitis
#12
Wenxue Yang, Xiaoping Yan, Qisheng Xia, Qingwen Tao, Xiaowei Gan, Yingze Zhang, Zhihua Chen, Weiping Kong
OBJECTIVES: We quantified the expression of six well-characterized microRNAs (miRNAs) in peripheral blood mononuclear cells to see whether they can predispose to syndesmophytes in ankylosing spondylitis (AS) patients. METHODS: This is a cross-sectional study involving 46 AS patients (23/23 with/without syndesmophytes) and 22 healthy controls. miRNAs expression was quantified by real-time PCR. RESULTS: Six examined miRNAs were comparably expressed between AS patients without syndesmophytes and healthy controls (p > ...
April 18, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29656682/potential-utility-of-core-needle-biopsy-in-the-diagnosis-of-igg4-related-dacryoadenitis-and-sialadenitis
#13
Kenichi Takano, Tsuyoshi Okuni, Keisuke Yamamoto, Ryuta Kamekura, Ryoto Yajima, Motohisa Yamamoto, Hiroki Takahashi, Tetsuo Himi
No abstract text is available yet for this article.
April 16, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29578355/risk-factors-for-hypersensitivity-reactions-to-tocilizumab-introduction-in-systemic-juvenile-idiopathic-arthritis
#14
Ryuhei Yasuoka, Naomi Iwata, Naoki Abe, Toaki Kohagura, Haruna Nakaseko, Masaki Shimizu, Shinji Kawabe
OBJECTIVES: The objective of this study is to identify risk factors for hypersensitivity reaction (HSR) to tocilizumab (TCZ) in systemic juvenile idiopathic arthritis (sJIA). METHODS: Clinical records of 40 patients with sJIA administered TCZ at one center were retrospectively reviewed. Patients were divided into HSR or non-HSR groups depending on the presence of HSR between the first and third TCZ administrations; clinical and laboratory assessments, including serum cytokine profile, were compared...
April 16, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29575958/overall-benefits-provided-by-orthopedic-surgical-intervention-in-patients-with-rheumatoid-arthritis
#15
Hajime Ishikawa, Asami Abe, Toshihisa Kojima, Masayo Kojima, Naoki Ishiguro, Yumi Nomura, Hiroshi Otani, Eriko Hasegawa, Daisuke Kobayashi, Satoshi Ito, Kiyoshi Nakazono, Akira Murasawa
OBJECTIVES: To clarify systemic effects of orthopedic surgical intervention in patients with rheumatoid arthritis (RA). METHODS: A prospective observational cohort study was performed in RA patients who were scheduled to have primary elective orthopedic surgeries. Assessments were performed at baseline, 6 and 12 months after surgery using J-HAQ, General Health, EQ-5D, BDI-II, DAS28-CRP(4) and CRP for all registered patients, DASH and grip power for patients with upper-extremity surgeries, TUG for patients with lower-extremity surgeries, and JSSF for patients with ankle and forefoot surgeries...
April 16, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29652213/ovarian-reserve-in-young-juvenile-idiopathic-arthritis-patients
#16
Gabriela R V Ferreira, Renato B Tomioka, Nadia E Aikawa, Elaine P Leon, Gustavo A R Maciel, Paulo C Serafini, Edmund C Baracat, Claudia Goldenstein-Schainberg, Rosa M R Pereira, Eloisa Bonfá, Clovis A Silva
OBJECTIVES: Juvenile idiopathic arthritis (JIA) occurs during reproductive age, however, there are not systematic data regarding ovarian function in this disease. METHODS: Twenty-eight post-pubertal JIA patients and age-matched 28 healthy controls were studied. Complete ovarian function was assessed during the early follicular phase of the menstrual cycle including anti-Müllerian hormone (AMH), estradiol, luteinizing hormone (LH), follicle stimulating hormone (FSH) and antral follicle count (AFC) by ovarian ultrasound, and anti-corpus lutheum antibodies (anti-CoL)...
April 13, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29652202/effect-of-sulfasalazine-use-on-the-presence-of-pneumocystis-organisms-in-the-lung-among-patients-with-rheumatoid-arthritis-a-test-negative-design-case-control-study-with-pcr-tests
#17
Takahiro Nunokawa, Naoto Yokogawa, Kota Shimada, Shoji Sugii
OBJECTIVE: To evaluate the effect of sulfasalazine (SSZ) on the presence of Pneumocystis jirovecii (P. jirovecii) in the lungs of rheumatoid arthritis (RA) patients. METHODS: We retrospectively studied episodes of suspected P. jirovecii pneumonia (PJP) which were examined for P. jirovecii with polymerase chain reaction (PCR). We employed a test negative design case-control study; the cases were episodes of suspected PJP that were positive for PCR, and the controls were episodes of suspected PJP that were negative for PCR...
April 13, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29652197/relationship-between-locomotive-syndrome-and-body-composition-among-community-dwelling-middle-age-and-elderly-individuals-in-japan-the-yakumo-study
#18
Satoshi Tanaka, Kei Ando, Kazuyoshi Kobayashi, Tetsuro Hida, Taisuke Seki, Koji Suzuki, Kenyu Ito, Mikito Tsushima, Masayoshi Morozumi, Masaaki Machino, Kyotaro Ota, Naoki Ishiguro, Yukiharu Hasegawa, Shiro Imagama
OBJECTIVES: Locomotive syndrome (LS) is a condition requiring nursing care for musculoskeletal disorders. Our aim was to evaluate the correlation between body composition, measured by bioelectrical impedance analysis (BIA), and LS, measured using the 25-question Geriatric Locomotive Functional Scale (GLFS-25). METHODS: We enrolled 286 individuals who were undergoing regular health follow-up. All individuals completed the GLFS-25, body composition analysis by BIA, and five physical performance tests related to LS: Timed up-and-go test, 10-m gait time, maximum stride length, back strength, and grip strength...
April 13, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29651889/how-to-conduct-research-of-rare-autoimmune-diseases
#19
Chikashi Terao
Rare autoimmune diseases are difficult to conduct researches in spite of present era with advanced scientific progress. Research using genetic approach is a promising way since genetic findings implicate causality of diseases. Still, there are multiple obstacles preventing genetic studies of rare diseases. Here, we list up the problems and propose solutions for them with detailed examples. The biggest problem is that it is difficult to collect a substantial number of DNA samples from patients with rare diseases...
April 13, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29532734/efficacy-and-safety-of-sirukumab-in-japanese-patients-with-active-rheumatoid-arthritis-who-were-refractory-or-intolerant-to-anti-tumor-necrosis-factor-therapy-subgroup-analysis-of-a-randomized-double-blind-multicenter-phase-3-study-sirround-t
#20
Yoshiya Tanaka, Tsutomu Takeuchi, Masayoshi Harigai, Hisashi Yamanaka, Toshikazu Nakano, Koshiro Akagi, Yoshifumi Ukyo, Benjamin Hsu
OBJECTIVE: To evaluate the efficacy and safety of sirukumab, a human anti-interleukin six monoclonal antibody, in Japanese patients with rheumatoid arthritis who were refractory to anti-tumor necrosis factor therapy. METHODS: This subgroup analysis, based on a double-blind, placebo-controlled, 52-week phase 3, global study (SIRROUND-T) assessed the American College of Rheumatology (ACR) 20 response at week 16 (primary endpoint). Secondary endpoints: ACR 50, Disease Activity Score in 28 joints-C reactive protein, Health Assessment Questionnaire-Disability Index and safety were assessed...
April 13, 2018: Modern Rheumatology
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