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Modern Rheumatology

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https://www.readbyqxmd.com/read/29451049/the-increase-in-bone-mineral-density-by-bisphosphonate-with-active-vitamin-d-analogue-is-associated-with-the-serum-calcium-level-within-the-reference-interval-in-postmenopausal-osteoporosis
#1
Mayuko Kinoshita, Muneaki Ishijima, Haruka Kaneko, Lizu Liu, Masashi Nagao, Ryo Sadatsuki, Shinnosuke Hada, Hitoshi Arita, Takako Aoki, Makoto Yamanaka, Hidetoshi Nojiri, Yuko Sakamoto, Akifumi Tokita, Kazuo Kaneko
OBJECTIVES: To examine the factors associated with increase in lumbar spine bone mineral density (LS-BMD) by bisphosphonates (BPs) with active vitamin D analogue (aVD). METHODS: Two independent postmenopausal osteoporotic patients treated by BPs with aVD for 24 months (Study1:n = 93,Study2:n = 99) were retrospectively analyzed. RESULTS: In Study1, LS-BMD of the patients significantly increased for 24m (5.4%,p<0.001). A multiple regression analysis among baseline characteristics revealed that serum calcium (sCa:8...
February 16, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29451048/impact-of-radon-and-combinatory-radon-carbon-dioxide-spa-on-pain-and-hypertension-results-from-the-explorative-rad-on01-study
#2
Paul F Rühle, Gerhart Klein, Tatjana Rung, Hong Tiep Phan, Claudia Fournier, Rainer Fietkau, Udo S Gaipl, Benjamin Frey
OBJECTIVES: Therapies with low doses of radon have beneficial effects on patients suffering from chronic painful degenerative and inflammatory diseases. We already showed that this is accompanied by systemic immune modulations. We here focus on pain reducing effects of very low doses of radon by adding carbon dioxide water and its impact on heart rate variability (HRV), blood pressure and free radicals. METHODS: 100 patients receiving radon spa (1.200 Bq/l at 34°C or 600 Bq/l, 1 g/l CO 2 at 34°C) were monitored before and at three different time points after therapy...
February 16, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29451047/national-survey-of-japanese-patients-with-mevalonate-kinase-deficiency-reveals-distinctive-genetic-and-clinical-characteristics
#3
Takayuki Tanaka, Kohei Yoshioka, Ryuta Nishikomori, Hidemasa Sakai, Junya Abe, Yuriko Yamashita, Ryugo Hiramoto, Akira Morimoto, Eiichi Ishii, Hirokazu Arakawa, Utako Kaneko, Yusei Ohshima, Nami Okamoto, Osamu Ohara, Ikue Hata, Yosuke Shigematsu, Tomoki Kawai, Takahiro Yasumi, Toshio Heike
OBJECTIVES: Mevalonate kinase deficiency (MKD), a rare autosomal recessive autoinflammatory syndrome, is caused by disease-causing variants of the mevalonate kinase gene. A national survey was undertaken to investigate clinical and genetic features of MKD patients in Japan. METHODS: The survey identified ten patients with MKD. Clinical information and laboratory data were collected from medical records and by direct interviews with patients, their families, and their attending physicians...
February 16, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29448870/a-new-assessment-tool-for-ulnar-drift-in-patients-with-rheumatoid-arthritis-using-pathophysiological-parameters-of-the-metacarpophalangeal-joint
#4
Shogo Toyama, Ryo Oda, Daisaku Tokunaga, Daigo Taniguchi, Satoru Nakamura, Maki Asada, Hiroyoshi Fujiwara, Toshikazu Kubo
OBJECTIVES: To establish a new assessment tool for ulnar drift (UD) in rheumatoid arthritis. METHODS: We established an observational cohort of 67 patients (134 rheumatoid hands) beginning in 2004. Fifty-two patients (100 hands) had follow-up in 2009, and thirty-seven patients (63 hands) completed follow-up in 2015. UD was evaluated with the Fearnley classification and our scoring method, which assesses four parameters of the metacarpophalangeal joint. Cluster analysis using UD parameters divided hands into groups...
February 15, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29446698/radiological-fibrosis-score-is-strongly-associated-with-worse-survival-in-rheumatoid-arthritis-related-interstitial-lung-disease
#5
Yuhei Ito, Machiko Arita, Shogo Kumagai, Reoto Takei, Maki Noyama, Fumiaki Tokioka, Keisuke Nishimura, Takashi Koyama, Hiromasa Tachibana, Tadashi Ishida
OBJECTIVES: High-resolution computed tomography (HRCT) parenchymal patterns have been used to predict prognosis in patients with interstitial lung disease (ILD). In idiopathic pulmonary fibrosis, the fibrosis score (i.e., the combined extent of reticulation and honeycombing) has been associated with worse survival. This study aimed to identify HRCT patterns and patient characteristics that can predict poor prognosis in rheumatoid arthritis-related ILD (RA-ILD). METHODS: We retrospectively analysed 65 patients with newly diagnosed RA-ILD from 2007 to 2016 at Kurashiki Central hospital...
February 15, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29446654/hypouricaemic-effects-of-yogurt-containing-lactobacillus-gasseri-pa-3-in-patients-with-hyperuricaemia-and-or-gout-a-randomized-double-blind-placebo-controlled-study
#6
Hisashi Yamanaka, Atsuo Taniguchi, Hiroshi Tsuboi, Hiroshi Kano, Yukio Asami
PURPOSE: Lactobacillus gasseri PA-3 (PA-3) has been previously shown to decrease serum uric acid (SUA) levels in subjects with increased SUA. In this study, we investigated whether PA-3 is also capable of decreasing SUA levels in patients with hyperuricaemia and/or gout. METHODS: Twenty-five patients with hyperuricaemia and/or gout completed this study. Urate-lowering drugs were discontinued for 12 weeks (week -4 to week 8). After flushing of urate-lowering drugs for 4 weeks (week 0), patients were randomized equally to receive diets containing yogurt beverages with PA-3 or without PA-3 for a duration of 8 weeks (week 8)...
February 15, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29442538/serum-cystatin-c-level-is-associated-with-locomotive-syndrome-risk-and-can-be-an-early-predictor-in-community-living-people-the-yakumo-study
#7
Satoshi Tanaka, Kei Ando, Kazuyoshi Kobayashi, Tetsuro Hida, Kenyu Ito, Mikito Tsushima, Masayoshi Morozumi, Masaaki Machino, Kyotaro Ota, Taisuke Seki, Koji Suzuki, Yoshihiro Nishida, Naoki Ishiguro, Yukiharu Hasegawa, Shiro Imagama
OBJECTIVES: The locomotive syndrome (LS) risk has been recently proposed as a criterion for evaluating physical ability. Serum cystatin C level is an early renal function marker and a cardiovascular disease predictor. This study aimed to evaluate the relationship between serum cystatin C level and LS risk. METHODS: We enrolled 54 participants and conducted the two-step test, stand-up test, 25-question geriatric locomotive function scale, LS risk test, Timed Up and Go test, back muscle strength, grip strength, blood test, and serum cystatin C level measurement...
February 14, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29442534/efficacy-and-safety-of-combination-therapy-with-prednisolone-and-oral-tacrolimus-for-progressive-interstitial-pneumonia-with-systemic-sclerosis-a-retrospective-study
#8
Junichi Konma, Takuya Kotani, Takeshi Shoda, Takayasu Suzuka, Youhei Fujiki, Koji Nagai, Kenichiro Hata, Shuzo Yoshida, Tohru Takeuchi, Shigeki Makino, Shigeki Arawaka
OBJECTIVES: We retrospectively investigated efficacy and safety of combination therapy with prednisolone (PSL) and tacrolimus (TAC) for progressive interstitial pneumonitis with systemic sclerosis (SSc-PIP). METHODS: We studied 11 patients with SSc-PIP who received combination therapy with PSL (0.5 mg/kg/day) and TAC (3 mg/day). RESULTS: Baseline Hugh-Jones grades were I, II, III, and IV in 2, 6, 2, and 1 patients, respectively. KL-6 values were elevated to 914 (300-2614) U/mL...
February 14, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29429391/comparative-effectiveness-of-oral-pharmacologic-interventions-for-knee-osteoarthritis-a-network-meta-analysis
#9
Sun-Young Jung, Eun Jin Jang, Seoung Wan Nam, Hyuk Hee Kwon, Seul Gi Im, Dam Kim, Soo-Kyung Cho, Dalho Kim, Yoon-Kyoung Sung
OBJECTIVES: To explore the relative efficacy of oral pharmacologic interventions in the treatment of knee OA. METHODS: A systematic literature review was conducted using the MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials databases to identify trials conducted in patients with knee OA with a minimum 6 weeks of follow-up. The standardized mean differences of the change from baseline to week 6 in Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain between the treatment groups were estimated using Bayesian random-effects network meta-analyses...
February 12, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29409370/clinical-practice-guideline-for-sj%C3%A3-gren-s-syndrome-2017
#10
Takayuki Sumida, Naoto Azuma, Masafumi Moriyama, Hiroyuki Takahashi, Hiromitsu Asashima, Fumika Honda, Saori Abe, Yuko Ono, Tomoya Hirota, Shintaro Hirata, Yoshiya Tanaka, Toshimasa Shimizu, Hideki Nakamura, Atsushi Kawakami, Hajime Sano, Yoko Ogawa, Kazuo Tsubota, Koufuchi Ryo, Ichiro Saito, Akihiko Tanaka, Seiji Nakamura, Etsuko Takamura, Masao Tanaka, Katsuya Suzuki, Tsutomu Takeuchi, Noriyuki Yamakawa, Tsuneyo Mimori, Akiko Ohta, Susumu Nishiyama, Toshio Yoshihara, Yasunori Suzuki, Mitsuhiro Kawano, Minako Tomiita, Hiroto Tsuboi
OBJECTIVES: To develop clinical practice guideline (CPG) for Sjögren's syndrome (SS) based on recently available clinical and therapeutic evidences. METHODS: The CPG committee for SS was organized by the Research Team for Autoimmune Diseases, Research Program for Intractable Disease of the Ministry of Health, Labor and Welfare (MHLW), Japan. The committee completed a systematic review of evidences for several clinical questions and developed CPG for SS 2017 according to the procedure proposed by the Medical Information Network Distribution Service (Minds)...
February 7, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29385876/antiphospholipid-syndrome-the-best-prophet-of-the-future
#11
Olga Amengual, Tatsuya Atsumi
The antiphospholipid syndrome (APS) is an autoimmune disorder characterized by the occurrence of venous and arterial thromboses, often multiple, and obstetric-related adverse events in the presence of antiphospholipid antibodies (aPL). APS, first described in 1983, as thrombosis, abortion and cerebral disease, is nowadays recognised as a systemic disease with a wide constellation of clinical manifestations related to acute and chronic vascular lesions. The presence of aPL is the serological hallmark of APS representing a heterogeneous population of autoantibodies with many antigenic specificities directed to phospholipid-binding proteins, either alone or in combination with phospholipids...
February 1, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29385874/stage-classification-of-igg4-related-dacryoadenitis-and-sialadenitis-by-the-serum-cytokine-environment
#12
Motohisa Yamamoto, Kenichi Takano, Ryuta Kamekura, Chisako Suzuki, Shingo Ichimiya, Tetsuya Himi, Hiroshi Nakase, Hiroki Takahashi
OBJECTIVES: Patients with immunoglobulin-G4 related disease (IgG4-RD) diagnosed according to the comprehensive diagnostic criteria (CDC) show varied therapeutic responses and prognoses. We assumed that there are clinical stages in IgG4-RD and have verified it using serum cytokine levels in the groups classified by lesion distribution. METHODS: Definite IgG4-related dacryoadenitis and sialadenitis (IgG4-DS) cases were divided according to the CDC for IgG4-RD into 11 cases with focal type and 30 cases with systemic type...
February 1, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29385873/dysfunction-of-trim21-in-interferon-signature-of-systemic-lupus-erythematosus
#13
Reikou Kamiyama, Ryusuke Yoshimi, Mitsuhiro Takeno, Yasuhiro Iribe, Toshinori Tsukahara, Daiga Kishimoto, Yosuke Kunishita, Yumiko Sugiyama, Naomi Tsuchida, Hiroto Nakano, Kaoru Minegishi, Maasa Tamura, Yukiko Asami, Yohei Kirino, Yoshiaki Ishigatsubo, Keiko Ozato, Hideaki Nakajima
OBJECTIVES: TRIM21 is an E3 ubiquitin ligase for interferon regulatory factors (IRFs) that are involved in innate and acquired immunity. Here we evaluated the role of TRIM21 in the interferon (IFN) signature of systemic lupus erythematosus (SLE). METHODS: Twenty SLE patients and 24 healthy controls were enrolled in this study. We analyzed mRNA expression of TRIM21, type I IFN, and IFN-inducible genes in peripheral blood mononuclear cell (PBMCs). The protein levels of IRFs were assessed by Western blotting in PBMCs cultured with or without MG-132...
February 1, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29385865/three-dimensional-limb-lengthening-after-total-knee-arthroplasty-in-a-simulation-study
#14
Takaaki Ohmori, Tamon Kabata, Yoshitomo Kajino, Daisuke Inoue, Tadashi Taga, Takashi Yamamoto, Tomoharu Takagi, Junya Yoshitani, Takuro Ueno, Ken Ueoka, Hiroyuki Tsuchiya
OBJECTIVES: Limb lengthening after total knee arthroplasty (TKA) has been reported in some cases, all of which were evaluated using 2-dimensional images. To our knowledge, no case has been evaluated using 3-dimensional (3D) images. We investigated 3D limb lengthening after TKA. METHODS: We simulated 100 varus knees using 3D templating software. Virtual TKA was performed to maintain the original joint line by conducting a measured-resection technique. We examined the relationships of 3D distance between the femoral head center and ankle center before and after TKA, degree of hip-knee-ankle angle (HKA) improvement, and degree of flexion contracture angle improvement...
February 1, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29385862/analysis-of-serum-il-38-in-juvenile-onset-systemic-lupus-erythematosus
#15
Yusuke Takeuchi, Tomoko Seki, Norimoto Kobayashi, Kenji Sano, Tomonari Shigemura, Hisashi Shimojo, Kazuhiko Matsumoto, Kazunaga Agematsu
No abstract text is available yet for this article.
February 1, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29325462/tocilizumab-treatment-in-patients-with-rheumatoid-arthritis-is-associated-with-reduced-fibrinogen-levels-and-increased-blood-loss-after-total-knee-arthroplasty
#16
Hitoshi Imamura, Shigeki Momohara, Koichiro Yano, Yu Sakuma, Masanori Nakayama, Haruki Tobimatsu, Katsunori Ikari
OBJECTIVE: Since IL-6 has been associated with activation of the coagulation cascade and upregulation of fibrinogen transcription, we retrospectively tested the hypothesis that patients with rheumatoid arthritis (RA) treated with tocilizumab (TCZ) may lose more blood when undergoing total knee arthroplasty (TKA). METHODS: This study included 115 RA patients who underwent primary TKA and were preoperatively tested for fibrinogen levels. The blood volume of each patient was calculated using the Nadler formula, and estimated blood loss after TKA was calculated as the change between pre-operative and post-operative hematocrits...
January 30, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29363990/multicenter-double-blind-randomized-controlled-trial-to-evaluate-the-effectiveness-and-safety-of-bortezomib-as-a-treatment-for-refractory-systemic-lupus-erythematosus
#17
Tomonori Ishii, Yoshiya Tanaka, Atsushi Kawakami, Kazuyoshi Saito, Kunihiro Ichinose, Hiroshi Fujii, Yuko Shirota, Tuyoshi Shirai, Yoko Fujita, Ryu Watanabe, Shih-Wei Chiu, Takuhiro Yamaguchi, Hideo Harigae
OBJECTIVES: To evaluate the efficacy and safety of bortezomib for treating systemic lupus erythematosus (SLE), in patients whose disease activity could not be controlled. METHODS: Fourteen SLE patients with persistent disease activity were selected, who required prednisolone doses of >10 mg/day despite concomitant immunosuppressive therapy. Patients were randomly administered either bortezomib or a placebo, eight times. The primary and secondary end-points were a change in anti-dsDNA antibody titer at week 24 and the SLE Responder Index (SRI), respectively...
January 24, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29357721/capillary-abnormalities-observed-by-nailfold-video-capillaroscopy-in-japanese-patients-with-connective-tissue-diseases
#18
Yuki Ichimura, Yasushi Kawaguchi, Kae Takagi, Akiko Tochimoto, Tomoaki Higuchi, Sayuri Kataoka, Yasuhiro Katsumata, Hisashi Yamanaka
No abstract text is available yet for this article.
January 22, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29351724/the-role-of-extracellular-matrix-components-in-angiogenesis-and-fibrosis-possible-implication-for-systemic-sclerosis
#19
Vasiliki Liakouli, Paola Cipriani, Paola Di Benedetto, Piero Ruscitti, Francesco Carubbi, Onorina Berardicurti, Noemi Panzera, Roberto Giacomelli
Extracellular matrix (ECM) plays a crucial role in the regulation of both physiological and pathological angiogenesis. ECM homeostasis and function is ensuring by the tightly regulation of the different ECM components including, collagens, proteoglycans and a variety of different glycoproteins. An altered expression of the above ECM molecules as well as an imbalance between the action of matrix remodeling enzymes and their tissue inhibitors is known to be responsible for impaired angiogenesis and fibrosis. Systemic Sclerosis (SSc) is an autoimmune disease characterized by micro-angiopathy, failure of reparative angiogenesis and excessive fibrosis of the skin and various internal organs, dues to an increased production of ECM...
January 19, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29347862/survey-of-the-awareness-of-adult-rheumatologists-regarding-transitional-care-for-patients-with-juvenile-idiopathic-arthritis-in-japan
#20
Toshihiro Matsui, Takumi Matsumoto, Fumio Hirano, Fumika Tokunaga, Keisuke Okamoto, Shigeto Tohma, Tomohiro Morio, Hitoshi Kohsaka, Masaaki Mori
OBJECTIVES: To understand the current status of adult rheumatology care for patients who had previously had juvenile idiopathic arthritis (JIA) (excluding systemic JIA), and to identify issues interfering with the transition from pediatric to adult care in Japan. METHODS: Questionnaire-based survey among 30 adult rheumatologists. RESULTS: Eighty-seven percent of adult rheumatologists responded that they had provided medical care to adults who had had JIA; 44% of them had felt hesitation or anxiety when providing such care...
January 18, 2018: Modern Rheumatology
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