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Modern Rheumatology

Yumi Tsuchida, Shuji Sumitomo, Hirofumi Shoda, Kanae Kubo, Keishi Fujio, Kazuhiko Yamamoto
No abstract text is available yet for this article.
October 25, 2016: Modern Rheumatology
Kumi Shidara, Ayako Nakajima, Eisuke Inoue, Daisuke Hoshi, Naoki Sugimoto, Yohei Seto, Eiichi Tanaka, Katsunori Ikari, Atsuo Taniguchi, Hisashi Yamanaka
OBJECTIVE: To validate the minimally important difference (MID) of physical function using the Japanese version of the Health Assessment Questionnaire (J-HAQ) in a cohort of rheumatoid arthritis (RA). METHODS: Patients who participated in a cohort study in both October 2008 and April 2009 were analyzed. Patients self-rated their change in overall status over 6 months using a 5-point Likert scale ("much better", "somewhat better", "same", "somewhat worse", or "much worse")...
October 21, 2016: Modern Rheumatology
Daigo Taniguchi, Ryo Oda, Kazuya Ikoma, Shogo Toyama, Ryota Takatori, Kan Imai, Yusuke Hara, Koshiro Sawada, Daisaku Tokunaga, Hiroyoshi Fujiwara, Toshikazu Kubo
OBJECTIVE: To examine the recurrence of deformity after silicone implant arthroplasty combined with resection arthroplasty for severe forefoot deformity in patients with rheumatoid arthritis. METHODS: We reviewed the long-term results of this procedure for 27 feet in 15 patients. Their average age and disease duration at the time of operation were 58.6 years and 17.5 years, respectively, and the average follow-up period was 10.3 years. RESULTS: An improved hallux valgus angle (45...
October 21, 2016: Modern Rheumatology
Minan Y Al-Ezzi, Neha Pathak, Anwar R Tappuni, Khalid S Khan
OBJECTIVES: The aim of this study is to assess the impact of dryness caused by primary Sjögren's Syndrome (pSS) on smell, taste and sexual function in female patients, and its influence on quality of life. METHODS: Electronic databases including MEDLINE via Ovid, Web of Science, SCOUPUS, EMBASE and COCHRANE LIBRARY were searched until April 2016. Studies that assessed the function of smell, taste and sexuality in pSS patients, defined by the American European Consensus Group (AECG) criteria...
October 20, 2016: Modern Rheumatology
Daigo Komatsu, Yukiharu Hasegawa, Toshihisa Kojima, Taisuke Seki, Yoshitoshi Higuchi, Naoki Ishiguro
OBJECTIVES: Joint space narrowing and osteophyte formation, radiographic features of knee osteoarthritis (OA), are not necessarily synchronous processes. We evaluated the relationship between medial minimum joint space width (mJSW) and osteophyte formation. METHODS: We conducted a retrospective study of 1050 individuals (424 males; 626 females; mean age 64.9 years) who underwent knee radiography as part of a health screening program, between 2011 and 2013. mJSW and tibial osteophyte area (OF) were quantified using automated software...
October 14, 2016: Modern Rheumatology
(no author information available yet)
No abstract text is available yet for this article.
October 10, 2016: Modern Rheumatology
Kaori Watanabe-Imai, Masayoshi Harigai, Ken-Ei Sada, Masahiro Yamamura, Takao Fujii, Hiroaki Dobashi, Koichi Amano, Satoshi Ito, Sakae Homma, Shunichi Kumagai, Shogo Banno, Yoshihiro Arimura, Hirofumi Makino
OBJECTIVES: The purpose of this study was to identify the clinical characteristics and predictors of serious infections (SIs) in the RemIT-JAV, a nationwide, prospective, inception cohort study for Japanese patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). METHODS: We analyzed SIs within six months of remission induction therapy in 156 AAV patients. Hazard ratios with 95% confidence intervals (CIs) for SIs were calculated using the COX proportional hazard model...
October 10, 2016: Modern Rheumatology
Noritada Yoshikawa, Noriaki Shimizu, Masaaki Uehara, Aya Oda, Ryo Matsumiya, Erika Matsubara, Hiroshi Kobayashi, Osamu Hosono, Akiko Kuribara-Souta, Hiroyuki Baba, Fumitaka Nagamura, Shigeru Kiryu, Hirotoshi Tanaka
OBJECTIVES: To test the effects of bolus supplementation of branched-chain amino acids (BCAA) on skeletal muscle mass, strength, and function in patients with rheumatic disorders taking glucocorticoid (GC). METHODS: Patients with rheumatic disorders treated with prednisolone (≥10 mg/day) were randomized to ingest additional daily 12 g of BCAA (n = 9) or not (n = 9) for 12 weeks. At baseline, and 4, 8, and 12 weeks, they underwent bioelectrical impedance analysis, muscle strength and functional tests, and computed tomography analysis for cross-sectional area of mid-thigh muscle...
September 28, 2016: Modern Rheumatology
Hayato Kinoshita, Naohisa Miyakoshi, Tsuyoshi Kashiwagura, Yuji Kasukawa, Yusuke Sugimura, Yoichi Shimada
OBJECTIVES: This study aimed to investigate the efficacy of denosumab (compared with that of bisphosphonates) for preventing secondary osteoporosis and inflammation caused by excessive bone resorption in Japanese rheumatoid arthritis (RA) patients never previously treated for osteoporosis. METHODS: Ninety-eight patients with coexisting RA and osteoporosis were enrolled. The patients were subdivided by whether they were treated with denosumab (n = 49) or traditional bisphosphonates (n = 49)...
September 23, 2016: Modern Rheumatology
Shogo Matsuda, Shuzo Yoshida, Tohru Takeuchi, Yohei Fujiki, Ayaka Yoshikawa, Shigeki Makino
We report the case of a 66-year-old man with seropositive rheumatoid arthritis who developed neurologically asymptomatic rheumatoid meningitis (RM) revealed by MRI. RM worsened and chest CT showed pericardial effusion, pleural effusion, and bilateral consolidation, and his serum C3 level was decreased. We diagnosed systemic rheumatic vasculitis based on these findings. After a review of more than 20 previously reported cases of RM, this is the first case of RM without central nerve system symptoms.
September 23, 2016: Modern Rheumatology
Vasiliki-Kalliopi Bournia, George Kitas, Athanasios D Protogerou, Petros P Sfikakis
Although large-scale population studies have shown that non-steroidal anti-inflammatory drugs (NSAIDs) increase the risk of myocardial infarction, this is not confirmed in patients with rheumatoid arthritis (RA). Herein, we review the litterature on the differential effects of NSAIDs on cardiovascular risk in osteoarthritis (OA) versus RA and discuss possible explanations for this discrepancy. To assess a potential additive effect of age in non-RA populations, we compared weighted mean age between RA patients and unselected NSAID users included in cohort and case-control studies that estimate the cardiovascular risk of NSAIDs, assuming that the main indication for NSAID usage in elderly populations is OA...
September 23, 2016: Modern Rheumatology
Tian Qian, Fangru Chen, Xiaowei Shi, Jian Li, Min Li, Yan Chen, Fei Hao, Dongmei Zhang
OBJECTIVES: We aimed to examine CCAAT/enhancer-binding protein β (C/EBP β), TNF-alpha-induced protein 3 (TNFAIP3), and TNFAIP3-interacting protein 1 (TNIP1) expression in peripheral blood mononuclear cells (PBMCs) of systemic lupus erythematosus (SLE) patients to assess their relationship in SLE pathogenesis. METHODS: C/EBP β, TNIP1, and TNFAIP3 expression was assessed in PBMCs from 20 SLE patients and 20 controls by western blotting. The correlation between C/EBP β/TNFAIP3/TNIP1 expression and SLE disease activity was determined by Spearman's rank...
September 23, 2016: Modern Rheumatology
Satoshi Sato, Yoji Uejima, Meika Nanbu, Eisuke Suganuma, Tadamasa Takano, Risa Tanaka, Tomoyuki Kabuki, Eiji Oguma, Tsutomu Oh-Ishi, Yutaka Kawano
OBJECTIVES: The aim of this study was to determine the clinical phenotype and outcome of interstitial lung disease (ILD) complicated with juvenile dermatomyositis (JDM) or juvenile polymyositis (JPM). METHODS: This was a single-center retrospective study. From 1984 to 2015, we retrospectively reviewed 29 patients who were diagnosed with JDM/JPM, among whom eight cases were ILD and 21 were non-ILD. The clinical features and laboratory findings included chest computed tomography (CT) images that were compared between the patients with ILD and non-ILD...
September 20, 2016: Modern Rheumatology
Masato Mori, Motomu Hashimoto, Takashi Matsuo, Takao Fujii, Moritoshi Furu, Hiromu Ito, Hiroyuki Yoshitomi, Jun Hirose, Yoshinaga Ito, Shuji Akizuki, Ran Nakashima, Yoshitaka Imura, Naoichiro Yukawa, Hajime Yoshifuji, Koichiro Ohmura, Tsuneyo Mimori
OBJECTIVE: To determine how cell-cell contact with synovial fibroblasts (SF) influence on the proliferation and cytokine production of CD4(+ )T cells. METHODS: Naïve CD4(+ )T cells were cultured with SF from rheumatoid arthritis patients, stimulated by anti-CD3/28 antibody, and CD4(+ )T cell proliferation and IFN-γ/IL-17 production were analyzed. To study the role of adhesion molecules, cell contact was blocked by transwell plate or anti-intracellular adhesion molecule-1 (ICAM-1)/vascular cell adhesion molecule-1(VCAM-1) antibody...
September 13, 2016: Modern Rheumatology
Marco Lanzillotta, Corrado Campochiaro, Matteo Trimarchi, Gianluigi Arrigoni, Simonetta Gerevini, Raffaella Milani, Enrica Bozzolo, Matteo Biafora, Elena Venturini, Maria Pia Cicalese, John H Stone, Maria Grazia Sabbadini, Emanuel Della-Torre
OBJECTIVE: A series of destructive and tumefactive lesions of the midline structures have been recently added to the spectrum of IgG4-related disease (IgG4-RD). We examined the clinical, serological, endoscopic, radiological, and histological features that might be of utility in distinguishing IgG4-RD from other forms of inflammatory conditions with the potential to involve the sinonasal area and the oral cavity. METHODS: We studied 11 consecutive patients with erosive and/or tumefactive lesions of the midline structures referred to our tertiary care center...
September 13, 2016: Modern Rheumatology
Toshiaki Shimizu, Hiroyuki Yamashita, Yuko Takahashi, Hiroshi Kaneko, Akio Mimori
No abstract text is available yet for this article.
September 2, 2016: Modern Rheumatology
Isao Matsushita, Hiraku Motomura, Eiko Seki, Tomoatsu Kimura
OBJECTIVES: The long-term effects of tumour necrosis factor (TNF)-blocking therapies on weight-bearing joints in patients with rheumatoid arthritis (RA) have not been fully characterized. The purpose of this study was to assess the radiographic changes of weight-bearing joints in patients with RA during 3-year of TNF-blocking therapies and to identify factors related to the progression of joint damage. METHODS: Changes in clinical variables and radiological findings in 243 weight-bearing joints (63 hips, 54 knees, 71 ankles and 55 subtalar joints) in 38 consecutive patients were investigated during 3 years of treatment with TNF-blocking agents...
September 2, 2016: Modern Rheumatology
Hui Li, Chao Zeng, Jie Wei, Tuo Yang, Shu-Guang Gao, Wei Luo, Yu-Sheng Li, Yi-Lin Xiong, Wen-Feng Xiao, Guang-Hua Lei
INTRODUCTION: This study aimed to examine the associations of dietary magnesium (Mg) intake and serum Mg concentration with the high-sensitivity C-reactive protein (hsCRP) level in early radiographic knee osteoarthritis (OA) patients. METHODS: Multivariable logistic regression was used to test the associations of dietary and serum Mg with the serum hsCRP in early radiographic knee OA patients after adjustment of a number of potential confounding factors. RESULTS: A total of 936 early radiographic knee OA patients were included...
September 2, 2016: Modern Rheumatology
Yoshiya Tanaka, Hisashi Yamanaka, Tsutomu Takeuchi, Makoto Inoue, Kazuyoshi Saito, Yukihiko Saeki, Sang Joon Lee, Yoshihiro Nambu
OBJECTIVES: This study aimed to evaluate the safety of CT-P13 in patients with rheumatoid arthritis (RA) during long-term treatment or after switching from innovator infliximab (IFX). METHODS: Patients who completed 54 weeks of treatment in a phase I/II study (PI/II) received CT-P13 at an initial dose of 3 mg/kg at Week 62, with dose increases permitted up to 10 mg/kg. The primary endpoint was adverse event (AE) incidence. RESULTS: Thirty-four of 38 patients in the maintenance group and 29 of 33 in the switch group reported at least one AE...
September 1, 2016: Modern Rheumatology
Shin-Ya Kawashiri, Ayako Nishino, Toshimasa Shimizu, Masataka Umeda, Shoichi Fukui, Yoshikazu Nakashima, Takahisa Suzuki, Tomohiro Koga, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Kiyoshi Aoyagi, Atsushi Kawakami
OBJECTIVE: We evaluated whether the early responsiveness of ultrasound synovitis can predict the clinical response in rheumatoid arthritis (RA) patients treated with biologic disease-modifying anti-rheumatic drugs (bDMARDs). METHODS: Articular synovitis was assessed by ultrasound at 22 bilateral wrist and finger joints in 39 RA patients treated with bDMARDs. Each joint was assigned a gray-scale (GS) and power Doppler (PD) score from 0 to 3, and the sum of the GS or PD scores was considered to represent the ultrasound disease activity...
September 1, 2016: Modern Rheumatology
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