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Modern Rheumatology

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https://www.readbyqxmd.com/read/28165852/current-approach-to-the-diagnosis-of-igg4-related-disease-combination-of-comprehensive-diagnostic-and-organ-specific-criteria
#1
Hisanori Umehara, Kazuichi Okazaki, Takuji Nakamura, Tomomi Satoh-Nakamura, Akio Nakajima, Mitsuhiro Kawano, Tsuneyo Mimori, Tsutomu Chiba
IgG4-related disease (IgG4-RD) is a fascinating clinical entity proposed by Japanese investigators, and includes a wide variety of diseases, formerly diagnosed as Mikulicz's disease (MD), autoimmune pancreatitis (AIP), interstitial nephritis, prostatitis, retroperitoneal fibrosis, etc. Although all clinicians in every field of medicine may encounter this new disease, a unifying diagnostic criteria has not been established. In 2011, the Japanese IgG4 team, organized by the Ministry of Health, Labor and Welfare (MHLW) of Japan, published comprehensive diagnostic criteria for IgG4-RD...
February 6, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28165841/survey-of-attitudes-of-non-pediatric-rheumatologists-among-councilors-of-the-japan-college-of-rheumatology-regarding-transitional-care
#2
Takako Miyamae, Syuji Takei, Yasuhiko Itoh, Hisashi Yamanaka
Objectives The transition from pediatric to adult healthcare systems has recently received worldwide attention. Surveys of the attitudes of Japanese non-pediatric rheumatologists regarding transitional care were conducted. Methods Non-pediatric rheumatologists among councilors of the Japan College of Rheumatology were enrolled in the surveys. Experiences of adult patients with childhood-onset rheumatic diseases, ideal medical care for these patients, and factors that made the transition to adult care difficult were examined via e-mail...
February 6, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28165838/microarray-analysis-of-circulating-micrornas-in-familial-mediterranean-fever
#3
Taizo Wada, Tomoko Toma, Yusuke Matsuda, Akihiro Yachie, Saori Itami, Yoshihiro Taguchi, Yoshiki Murakami
OBJECTIVES: Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by mutations in MEFV. Mutations in exon 10 are associated with typical FMF phenotypes, whereas the pathogenic role of variants in exons 2 and 3 remains uncertain. Recent evidence suggests that circulating microRNAs are potentially useful biomarkers in several diseases. Therefore, their expression was assessed in FMF. METHODS: The subjects were 24 patients with FMF who were between attacks: 8 with exon 10 mutations (group A), 8 with exon 3 mutations (group B), and 8 without exon 3 or 10 mutations (group C)...
February 6, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28151032/the-frequency-of-the-celiac-disease-among-children-with-familial-mediterranean-fever
#4
Yasin Sahin, Amra Adrovic, Kenan Barut, Tufan Kutlu, Fugen Cullu-Cokugras, Sezgin Sahin, Ozgur Kasapcopur, Tulay Erkan
OBJECTIVES: We aimed to assess the frequency of celiac disease (CD) in patients with Familial Mediterranean Fever (FMF). METHODS: This is a prospective study was carried out from October 2015 to March 2016. A total of 303 patients with FMF were included. We used 98 sex- and age-matched healthy subjects as a control group. Levels of total IgA and tissue transglutaminase (tTG) IgA antibody were measured in all groups. Those with increased level of tTG IgA were tested for anti-endomysium IgA antibodies (EMA)...
February 2, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28150518/chloroquine-attenuates-tlr3-ifn-%C3%AE-signaling-in-cultured-normal-human-mesangial-cells-a-possible-protective-effect-against-renal-damage-in-lupus-nephritis
#5
Tadaatsu Imaizumi, Ryo Hayakari, Tomoh Matsumiya, Hidemi Yoshida, Kazushi Tsuruga, Shojiro Watanabe, Shogo Kawaguchi, Hiroshi Tanaka
BACKGROUND: Chloroquine has been reported to protect against renal damage in lupus nephritis (LN), however, its detailed mechanism in glomerular inflammation remains unclear. Upregulation of the type I interferon (IFN) system plays a pivotal role in LN pathogenesis, therefore, we examined whether chloroquine inhibits Toll-like receptor 3 (TLR3)/IFN-β signaling in cultured normal human mesangial cells (MCs). METHODS: We examined chloroquine effect on the representative TLR3/IFN-β signaling axis, TLR3/IFN-β/retinoic acid-inducible gene-I (RIG-I)/CCL5 in MCs treated with polyinosinic-polycytidylic acid (poly IC), a synthetic viral dsRNA analog and analyzed the expression of these molecules using reverse transcriptase-polymerase chain reaction and enzyme-linked immunosorbent assay...
February 2, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28150515/characterization-of-a-murine-model-with-arteritis-induced-by-nod1-ligand-fk565-a-comparative-study-with-a-caws-induced-model
#6
Ryuji Ohashi, Ryuji Fukazawa, Makoto Watanabe, Koji Hashimoto, Nobuko Suzuki, Noriko Nagi-Miura, Naohito Ohno, Akira Shimizu, Yasuhiko Itoh
OBJECTIVE: Kawasaki disease (KD) occurs via activation of the innate immune system. Nucleotide oligomerization domain -1 (NOD1) is a pattern recognition receptor regulating the innate immunity. We characterized histopathology of arteritis induced by FK565, a ligand for NOD1, in mice, compared with Candida albicans water-soluble fraction (CAWS)-induced model. METHODS: Vasculitis was induced by injection of FK565 or CAWS into C57BL6/J mice (n = 9 and n = 11, respectively)...
February 2, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28150514/maintenance-treatment-using-abatacept-with-dose-reduction-after-achievement-of-low-disease-activity-in-patients-with-rheumatoid-arthritis-matador-a-prospective-multicenter-single-arm-pilot-clinical-trial
#7
Shinsuke Yasuda, Kazumasa Ohmura, Hiroshi Kanazawa, Takashi Kurita, Yujiro Kon, Tomonori Ishii, Yuichiro Fujieda, Satoshi Jodo, Kazuhide Tanimura, Michio Minami, Tomomasa Izumiyama, Takumi Matsumoto, Yoshiharu Amasaki, Yoko Suzuki, Hideki Kasahara, Naofumi Yamauchi, Masaru Kato, Tamotsu Kamishima, Akito Tsutsumi, Hiromitsu Takemori, Takao Koike, Tatsuya Atsumi
OBJECTIVES: To preliminarily evaluate the feasibility of maintenance therapy with reduced dose of intravenous abatacept (ABT) to 250mg/body/month after achieving remission or low disease activity (LDA). PATIENTS AND METHODS: RA patients treated with ABT at 13 sites were enrolled in this prospective interventional pilot study during the period between March 2013 and March 2015. Inclusion criteria were 1) age at 20 years or older, 2) under treatment with intravenous ABT monthly at approved doses, 3) DAS28-CRP lower than 2...
February 2, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28150513/loss-of-lean-body-mass-affects-low-bone-mineral-density-in-patients-with-rheumatoid-arthritis-results-from-the-tomorrow-study
#8
Tadashi Okano, Kentaro Inui, Masahiro Tada, Yuko Sugioka, Kenji Mamoto, Shigeyuki Wakitani, Tatsuya Koike, Hiroaki Nakamura
OBJECTIVES: Osteoporosis is one of the complications for patients with rheumatoid arthritis (RA). Rheumatoid cachexia, the loss of lean body mass, is another. However, the relationship between decreased lean body mass and reduced bone mineral density (BMD) in patients with RA has not been well studied. METHODS: This study included 413 participants, comprising 208 patients with RA and 205 age- and sex-matched healthy volunteers. Clinical data, BMD, bone metabolic markers (BMM) and body composition, such as lean body mass and percent fat, were collected...
February 2, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28142302/outcomes-of-modified-metatarsal-shortening-offset-osteotomy-for-forefoot-deformity-in-patients-with-rheumatoid-arthritis-short-to-mid-term-follow-up
#9
Makoto Hirao, Kosuke Ebina, Hideki Tsuboi, Akihide Nampei, Junichi Kushioka, Takaaki Noguchi, Shigeyoshi Tsuji, Hajime Owaki, Jun Hashimoto, Hideki Yoshikawa
OBJECTIVES: Advances in drug therapy for rheumatoid arthritis (RA) have been encouraging us to preserve the metatarsopharangeal (MTP) joint in correction of forefoot deformities, and original metatarsal shortening offset osteotomy was recommended as one of the conventional surgical options for forefoot deformities in RA cases. The objective of this study was to evaluate short- to mid-term outcomes of modified metatarsal shortening offset osteotomy. METHODS: A retrospective observational study was completed for 80 RA cases (mean follow-up period: 3...
February 1, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28121200/effectiveness-of-whole-body-magnetic-resonance-imaging-for-the-efficacy-of-biologic-anti-rheumatic-drugs-in-patients-with-rheumatoid-arthritis-a-retrospective-pilot-study
#10
Michihito Kono, Tamotsu Kamishima, Shinsuke Yasuda, Keita Sakamoto, Sawako Abe, Atsushi Noguchi, Toshiyuki Watanabe, Yuka Shimizu, Kenji Oku, Toshiyuki Bohgaki, Olga Amengual, Tetsuya Horita, Tatsuya Atsumi
OBJECTIVES: To evaluate the scoring of whole-body magnetic resonance imaging (WBMRI) for efficacy assessment in rheumatoid arthritis (RA) patients receiving biological disease-modifying anti-rheumatic drugs (bDMARDs). METHODS: Thirty consecutive RA patients receiving bDMARDs were included in this retrospective study. Contrast WBMRI was performed before and 1 year after bDMARDs initiation. RESULTS: At baseline, mean age was 57.1 years and mean disease duration was 3...
February 1, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28121199/functional-analysis-of-choline-transporters-in-rheumatoid-arthritis-synovial-fibroblasts
#11
Masayuki Seki, Yuiko Kawai, Chikanao Ishii, Tsuyoshi Yamanaka, Masato Odawara, Masato Inazu
OBJECTIVES: In this study, we examined the functional characteristics of choline uptake and sought to identify the transporters in rheumatoid arthritis synovial fibroblasts (RASFs). METHODS: The expression of choline transporters was evaluated by quantitative real-time PCR, western blotting, and immunocytochemistry. Time course, Na(+)-dependency, and kinetics of [(3)H]choline uptake were investigated. Effects of cationic drugs on the uptake of [(3)H]choline, cell viability, and caspase-3/7 activity were also examined...
February 1, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28121197/sinus-bradycardia-after-intravenous-pulse-methylprednisolone-therapy-in-patients-with-systemic-lupus-erythematosus
#12
Miho Ohshima, Kimito Kawahata, Hiroko Kanda, Kazuhiko Yamamoto
Sinus bradycardia is reported as an adverse effect of high-dose glucocorticoid therapy. We report three cases of systemic lupus erythematosus, wherein intravenous pulse methylprednisolone was administered. The patients' average baseline heart rate was 72 beats/min, which decreased 30% from baseline at 61 h after beginning the therapy. The average minimum heart rate was 38 beats/min, and this rate continued for 169 h on average. No other causes for bradycardia were found, suggesting that the administration of glucocorticoid pulse therapy resulted in decreased heart rate...
February 1, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/27539739/fibromyalgia-syndrome-and-temporomandibular-disorders-with-muscular-pain-a-review
#13
Ana Maria Moreno-Fernández, Emilio Jiménez-Castellanos, Alejandro Iglesias-Linares, Débora Bueso-Madrid, Ana Fernández-Rodríguez, Manuel de Miguel
OBJECTIVES: Temporomandibular disorders (TMD) refer to a group of clinical picture affecting the masticatory muscles and temporomandibular joint that are characterized by muscular or joint pain, dysfunction (limited or altered functions) and joint noises, as well as other associated symptoms, such as tension headaches, otalgia, dizziness, tinnitus, and others. Fibromyalgia (FM) is a syndrome of unknown etiology involving generalized chronic pain accompanied, in a high percentage of cases, by other symptoms such as asthenia, anxiety, depression, sleep disturbances, and other less frequent symptoms, such as temporomandibular disorders (TMD)...
February 1, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/27539357/suppression-of-glucose-6-phosphate-isomerase-induced-arthritis-by-oral-administration-of-transgenic-rice-seeds-expressing-altered-peptide-ligands-of-glucose-6-phosphate-isomerase
#14
Tomoya Hirota, Hiroto Tsuboi, Mana Iizuka-Koga, Hiroyuki Takahashi, Hiromitsu Asashima, Masahiro Yokosawa, Yuya Kondo, Masaru Ohta, Yuhya Wakasa, Isao Matsumoto, Fumio Takaiwa, Takayuki Sumida
OBJECTIVE: To investigate the effects of transgenic rice seeds expressing the altered peptide ligand (APL) of human glucose-6-phosphate-isomerase (hGPI325-339) in mice model of GPI-induced arthritis (GIA). METHODS: We generated transgenic rice expressing T-cell epitope of hGPI325-339 and APL12 contained in the seed endosperm. The transgenic rice seeds were orally administered prophylactically before the induction of GIA. The severity of arthritis and titers of serum anti-GPI antibodies were evaluated...
February 1, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28128680/corrigendum
#15
(no author information available yet)
No abstract text is available yet for this article.
January 27, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28121204/efficacy-of-golimumab-for-preventing-large-joint-destruction-in-patients-with-rheumatoid-arthritis-as-determined-by-the-arashi-score
#16
Katsuaki Kanbe, Koei Oh, Junji Chiba, Yasuo Inoue, Masashi Taguchi, Akiko Yabuki
OBJECTIVES: To investigate the inhibitory effect of golimumab on large joint destruction in patients with rheumatoid arthritis. METHODS: We recruited 45 patients with rheumatoid arthritis and evaluated the radiographic severity of large joint destruction using the ARASHI (assessment of rheumatoid arthritis by scoring of large joint destruction and healing in radiographic imaging) score. We evaluated 450 large joints including the elbow, shoulder, hip, knee and ankle at baseline and 52 weeks after treatment with golimumab...
January 25, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28121192/integrating-patients-perceptions-into-clinical-practice-guidelines-for-the-management-of-rheumatoid-arthritis-in-japan
#17
Masayo Kojima, Takeo Nakayama, Takashi Otani, Mieko Hasegawa, Yutaka Kawahito, Yuko Kaneko, Mitsumasa Kishimoto, Shintaro Hirata, Yohei Seto, Hirahito Endo, Hiromu Ito, Toshihisa Kojima, Keiichiro Nishida, Isao Matsushita, Kiichiro Tsutani, Ataru Igarashi, Naoyuki Kamatani, Nobuyuki Miyasaka, Hisashi Yamanaka
OBJECTIVE: Patients' values and preferences are among the key factors that determine the strength of recommendations presented in clinical practice guidelines (CPG). The aim of this study was to summarize the integration process for patients' perceptions into the development of CPG for rheumatoid arthritis (RA) management in Japan. METHODS: We used a mixed-methods approach. Questionnaires that could be self-administered were mailed to 2222 RA patients randomly selected from the Japan Rheumatism Friendship Association (JRFA) membership list that was age- and prefecture-stratified...
January 25, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28094589/leucine-rich-%C3%AE-2-glycoprotein-as-the-acute-phase-reactant-to-detect-systemic-juvenile-idiopathic-arthritis-disease-activity-during-anti-interleukin-6-blockade-therapy-a-case-series
#18
Masaki Shimizu, Yasuo Nakagishi, Natsumi Inoue, Mao Mizuta, Akihiro Yachie
OBJECTIVES: To assess the role of leucine-rich α2-glycoprotein (LRG) as a biomarker for monitoring systemic juvenile idiopathic arthritis (s-JIA) disease activity during interleukin (IL)-6 blockade treatment. METHODS: We serially measured serum LRG levels in four s-JIA patients treated with the anti-IL-6 receptor antibody tocilizumab and determined the correlation between clinical symptoms and other inflammatory biomarkers and proinflammatory cytokines, including IL-18, IL-6, neopterin, and tumor necrosis factor-α receptor type I and II...
January 17, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/27919202/body-mass-index-is-related-with-the-presence-of-syndesmophyte-in-axial-spondyloarthritis-data-from-the-korean-college-of-rheumatology-biologics-kobio-registry
#19
Seong-Kyu Kim, Jung-Yoon Choe, Shin-Seok Lee, Kichul Shin
OBJECTIVE: We investigated whether body mass index (BMI) is associated with parameters of disease activity and clinical manifestations in axial spondyloarthritis (axSpA). METHODS: Demographic, clinical, and radiological features and disease activity indexes from 789 axSpA patients (619 males and 170 females) were obtained from the Korean College of Rheumatology BIOlogics (KOBIO) registry. BMI (kg/m(2)) was classified into normal (BMI <23.0), overweight (23.0 ≤ BMI <25...
January 13, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/27919193/treatment-of-giant-cell-arteritis-a-literature-review
#20
Bénédicte Watelet, Maxime Samson, Hubert de Boysson, Boris Bienvenu
Giant-cell arteritis (GCA) is the most common vasculitis in people aged more than 50 years. Despite the frequency of this disease, there is currently no international consensus on its therapeutic modalities. The aim of this study was to conduct a review on an international literature about the treatment of GCA, whatever the clinical pattern might be. Oral corticosteroids remain the cornerstone treatment, possibly preceded by intravenous bolus in complicated forms. In cases of glucocorticoid (GC) dependence or GC-related side effects, a GC-sparing agent may be necessary...
January 13, 2017: Modern Rheumatology
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