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Modern Rheumatology

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https://www.readbyqxmd.com/read/28805137/differential-influences-of-fc-gamma-receptor-blocking-on-the-effects-of-certolizumab-pegol-and-infliximab-on-human-monocytes
#1
Takayuki Hoshiyama, Yu Matsueda, Toshihiro Tono, Yoshiyuki Arinuma, Tatsuo Nagai, Shunsei Hirohata
OBJECTIVES: To compare the effects of certolizumab pegol (CZP) and infliximab (IFX) on human monocytes. METHODS: Highly purified monocytes from healthy donors were cultured with CZP, IFX, control IgG1, or polyethylene glycol (PEG) at pharmacological attainable concentrations in culture medium with 10% autologous normal human serum (NHS) or with fetal bovine serum (FBS) for 24 h, after which the supernatants were replaced by fresh culture medium containing LPS...
August 14, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28805099/short-term-daily-teriparatide-in-patients-with-rheumatoid-arthritis
#2
Tetsuya Kaneko, Koichi Okamura, Yukio Yonemoto, Chisa Okura, Takahito Suto, Masahiro Tachibana, Yasuyuki Tamura, Makoto Inoue, Hirotaka Chikuda
OBJECTIVE: The aim of this study was to compare the efficacy of six-month teriparatide treatment followed by six-month bisphosphonate therapy with 12-month bisphosphonate monotherapy in Japanese rheumatoid arthritis (RA) patients who had not been previously treated for osteoporosis. METHODS: A total of 34 RA patients with osteoporosis were enrolled. Thirteen patients received six-month teriparatide prior to six-month minodronate therapy (PTH group), and 21 patients received 12-month minodronate therapy (BP group)...
August 14, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28766398/assessing-joint-destruction-in-the-knees-of-patients-with-rheumatoid-arthritis-by-using-a-semi-automated-software-for-magnetic-resonance-imaging-therapeutic-effect-of-methotrexate-plus-etanercept-compared-with-methotrexate-monotherapy
#3
Hiroyuki Oka, Yuho Kadono, Satoru Ohashi, Tetsuro Yasui, Kumiko Ono, Ko Matsudaira, Jinju Nishino, Sakae Tanaka
OBJECTIVES: To evaluate the prevention of knee joint destruction and clinical efficacy of methotrexate (MTX) plus etanercept (ETN) compared with MTX monotherapy in patients with rheumatoid arthritis (RA) by using semi-automated software for magnetic resonance imaging (MRI) scan analysis. MATERIALS AND METHODS: This study enrolled patients with active moderate-to-severe RA who displayed an inadequate response to oral MTX at screening. Patients were assigned to receive either MTX plus ETN or MTX monotherapy (≥10 mg/week)...
August 2, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28758827/lymphoproliferative-disorders-in-patients-with-rheumatoid-arthritis-in-the-era-of-widespread-use-of-methotrexate-a-review-of-the-literature-and-current-perspective
#4
Masayoshi Harigai
Lymphoproliferative disorders (LPD) in patients receiving methotrexate (MTX) have gained strong attention. In this article, I reviewed the basic and clinical findings of this issue. Patients with RA possess a high risk of lymphoma, but epidemiological evidence showing an association between the use of MTX and lymphoma is still limited. Rapid regression of LPD after stopping MTX in patients with RA strongly suggests that there is a causative relationship. Genetic predisposition, accumulated inflammation, impaired generation of Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes, effects of MTX on the regulation of EBV genes, and low hypermethylation of apoptosis-related genes are relevant to the development of LPD and rapid regression after cessation of MTX...
July 31, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28756710/steroid-therapy-and-renal-dysfunction-are-independently-associated-with-serum-levels-of-matrix-metalloproteinase-3-in-patients-with-rheumatoid-arthritis
#5
Yosuke Hattori, Daihei Kida, Atsushi Kaneko
OBJECTIVE: This study aimed to evaluate whether the level of serum matrix metalloproteinase-3 (MMP-3), a marker of synovium inflammation, is affected by clinical characteristics of patients in rheumatoid arthritis (RA) patients. METHODS: We analyzed data from 1087 female patients with RA. Pearson's correlation coefficients were calculated to explore associations between variables. Stepwise multiple linear regression analysis was performed to evaluate patient background variables that could potentially affect serum MMP-3 levels...
July 31, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28753077/low-dose-cyclosporine-a-in-the-treatment-of-resistant-proliferative-lupus-nephritis
#6
Marjan Sheikholeslami, Mehrzad Hajialilo, Seyed Sadreddin Rasi Hashemi, Aida Malek Mahdavi, Morteza Gojazadeh, Alireza Khabbazi
OBJECTIVE: This study aimed to evaluate long-term efficacy of low dose cyclosporine A (CsA) in the treatment of resistant proliferative lupus nephritis. METHODS: In this retrospective study, patients with biopsy proven proliferative lupus nephritis who were unresponsive to combination therapy with steroid plus mycophenolate mofetil (MMF) or cyclophosphamide (CYC) and had been treated with CsA were included. Efficacy monitoring was based on the systemic lupus erythematosus (SLE) disease activity index, dose of prednisolone, serum complement, anti-double stranded DNA (anti-dsDNA) titration, urine analysis, proteinuria, creatinine clearance, remission of the renal disease, renal survival and involvement of other organs...
July 28, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28741989/mithramycin-has-inhibitory-effects-on-gliostatin-and-matrix-metalloproteinase-expression-induced-by-gliostatin-in-rheumatoid-fibroblast-like-synoviocytes
#7
Naoe Tatematsu, Yuko Waguri-Nagaya, Yohei Kawaguchi, Yusuke Oguri, Kenji Ikuta, Masaaki Kobayashi, Masahiro Nozaki, Kiyofumi Asai, Mineyoshi Aoyama, Takanobu Otsuka
OBJECTIVES: Gliostatin (GLS) has angiogenic and arthritogenic activities and enzymatic activity as thymidine phosphorylase. Aberrant GLS production has been observed in the synovial membranes of patients with rheumatoid arthritis (RA). Matrix metalloproteinases (MMPs) are involved in joint destruction. Promoters of GLS and some MMP genes contain Sp1 binding sites. We examined the inhibitory effect of the Sp1 inhibitor mithramycin on GLS-induced GLS and MMP expression in cultured fibroblast-like synoviocytes (FLSs)...
July 25, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28741974/sarcopenia-and-physical-function-are-associated-with-inflammation-and-arteriosclerosis-in-community-dwelling-people-the-yakumo-study
#8
Tetsuro Hida, Shiro Imagama, Kei Ando, Kazuyoshi Kobayashi, Akio Muramoto, Kenyu Ito, Yoshimoto Ishikawa, Mikito Tsushima, Yoshihiro Nishida, Naoki Ishiguro, Yukiharu Hasegawa
OBJECTIVES: Sarcopenia reduces physical function, while chronic inflammation causes arteriosclerosis and decreases skeletal muscle. We conducted a cross-sectional study to elucidate the associations among sarcopenia, physical function, arteriosclerosis, and inflammation in community-dwelling people. METHODS: We recruited 335 participants in an annual health checkup. We diagnosed sarcopenia based on appendicular skeletal muscle mass index (aSMI) assessed by bioelectrical impedance analysis...
July 25, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28741973/characteristics-of-functional-impairment-in-patients-with-long-standing-rheumatoid-arthritis-based-on-range-of-motion-of-joints-baseline-data-from-a-multicenter-prospective-observational-cohort-study-to-evaluate-the-effectiveness-of-joint-surgery-in-the-treat
#9
Toshihisa Kojima, Hajime Ishikawa, Sakae Tanaka, Nobuhiko Haga, Keiichiro Nishida, Masao Yukioka, Jun Hashimoto, Hisaaki Miyahara, Yasuo Niki, Tomoatsu Kimura, Hiromi Oda, Shuji Asai, Koji Funahashi, Masayo Kojima, Naoki Ishiguro
OBJECTIVE: To explore the characteristics of functional impairment in patients with established rheumatoid arthritis (RA) based on the range of motion (ROM) of joints in a prospective observational study of RA patients undergoing joint surgery. METHODS: We collected data on demographics, Health Assessment Questionnaire Disability Index (HAQ-DI), and the ROM of large joints including the shoulder, elbow, wrist, hip, knee, and ankle. Associations between the ROM of each joint and disability in the eight HAQ-DI categories were determined using receiver operating characteristic (ROC) and logistic regression analyses...
July 25, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28741971/five-patients-who-died-during-treatment-for-adult-still-s-disease
#10
Rena Motohashi, Kazuhiko Uchiyama, Hidekazu Ikeuchi, Yoshihisa Nojima, Keiju Hiromura
No abstract text is available yet for this article.
July 25, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28722530/are-there-risk-factors-for-scleroderma-related-calcinosis
#11
Sneha Pai, Vivien Hsu
OBJECTIVES: Pathogenesis and risk factors of scleroderma associated calcinosis is poorly understood and there is no effective treatment. This study was performed to better understand the prevalence and clinical features associated with calcinosis in a cohort of SSc outpatients. METHODS: In this cross-sectional study, we compared clinical characteristics of SSc patients with (SSc-calcinosis) and without calcinosis (SSc-control) seen in the outpatient Rutgers-RWJ Scleroderma Program between 2012 and 2015...
July 19, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28722506/diffusion-weighted-magnetic-resonance-imaging-of-parotid-glands-before-and-after-abatacept-therapy-in-patients-with-sj%C3%A3-gren-s-syndrome-associated-with-rheumatoid-arthritis-utility-to-evaluate-and-predict-response-to-treatment
#12
Hiroyuki Takahashi, Hiroto Tsuboi, Masahiro Yokosawa, Hiromitsu Asashima, Tomoya Hirota, Yuya Kondo, Isao Matsumoto, Takayuki Sumida
OBJECTIVE: To compare parotid diffusion-weighted images (DWIs) taken before and after abatacept therapy in patients with Sjögren's syndrome (SS) associated with rheumatoid arthritis (RA) and to examine the utility in evaluation and prediction of response to therapy. METHODS: DWIs of the parotid glands taken at baseline and 52 weeks after initiation of abatacept were analyzed in nine SS patients with RA using relative standard deviation (RSD) of the entire glands and signal intensity ratio (SIR) within the residual parenchyma...
July 19, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28722504/role-of-tenascin-c-in-articular-cartilage
#13
Masahiro Hasegawa, Toshimichi Yoshida, Akihiro Sudo
Tenascin-C (TN-C) is a glycoprotein component of the extracellular matrix (ECM). TN-C consists of four distinct domains, including the tenascin assembly domain, epidermal growth factor-like repeats, fibronectin type III-like repeats, and the fibrinogen-like globe (FBG) domain. This review summarizes the role of TN-C in articular cartilage. Expression of TN-C is associated with the development of articular cartilage but markedly decreases during maturation of chondrocytes and disappears almost completely in adult articular cartilage...
July 19, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28722500/post-marketing-surveillance-study-of-the-long-term-use-of-mizoribine-for-the-treatment-of-lupus-nephritis-2-year-results
#14
Tsutomu Takeuchi, Kenya Okada, Hisao Yoshida, Nobuyuki Yagi
OBJECTIVES: To understand the status of mizoribine use in patients with lupus nephritis (LN) and to collect safety- and efficacy-related data on 2-year treatment with mizoribine. METHODS: A continuous survey was conducted between March 2010 and July 2015. RESULTS: The analysis set included 559 patients (mean age 39.5 years, females 82.6%, mean duration of systemic lupus erythematosus (SLE) 8.4 years, mean duration of LN 5.9 years). Renal function was satisfactory for 6 months, but worsened from 12 months, with significant worsening at 24 months...
July 19, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28718336/coexistence-of-takayasu-s-arteritis-and-ankylosing-spondylitis-may-not-be-accidental-is-there-a-need-for-a-new-subgroup-in-the-spondyloarthritis-family
#15
Pawel Mielnik, Anja Myhre Hjelle, Jan Leidulv Nordeide
Aortitis of ascending aorta is a recognized complication of ankylosing spondylitis (AS). There are a few published cases of diffuse aortitis and aorta collaterals inflammation that fulfill Takayasu's arteritis (TA) criteria coexisting with AS. We have reviewed published cases from literature and present three new cases of such coexistence. We identified three patients who fulfilled definite AS New York criteria in our Takayasu's vasculitis cohort of eight patients. One of this patients had been diagnosed with Crohn's disease before AS and TA diagnosis...
July 18, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28704126/economic-impact-of-adalimumab-treatment-in-japanese-patients-with-rheumatoid-arthritis-from-the-adalimumab-non-interventional-trial-for-up-verified-effects-and-utility-anouveau-study
#16
Yoshiya Tanaka, Kiyotaka Yamazaki, Ryo Nakajima, Shuichi Komatsu, Ataru Igarashi, Toshiro Tango, Tsutomu Takeuchi
OBJECTIVES: The objective of this study is to evaluate the economic impact of adalimumab (ADA) on Japanese rheumatoid arthritis (RA) patients. METHODS: ANOUVEAU was a 48-week multicenter, prospective, observational, single-cohort study. Work-related outcomes including absenteeism, presenteeism, overall work impairment (OWI), and activity impairment (AI) were evaluated using the RA-related work productivity and activity impairment (WPAI/RA). The amount of productivity loss was estimated via multiplication of absenteeism, presenteeism and OWI by the national average occupational wage for paid worker (PW) and part time worker (PTW), and via multiplication of AI by the estimated wage for domestic work for home maker (HM)...
July 13, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28701065/predictors-of-biologic-discontinuation-due-to-insufficient-response-in-patients-with-rheumatoid-arthritis-who-achieved-clinical-remission-with-biologic-treatment-a-multicenter-observational-cohort-study
#17
Shuji Asai, Takayoshi Fujibayashi, Takeshi Oguchi, Masahiro Hanabayashi, Masatoshi Hayashi, Hiroyuki Matsubara, Takayasu Ito, Yuichiro Yabe, Tsuyoshi Watanabe, Yuji Hirano, Yasuhide Kanayama, Atsushi Kaneko, Takefumi Kato, Hideki Takagi, Nobunori Takahashi, Koji Funahashi, Toki Takemoto, Nobuyuki Asai, Tatsuo Watanabe, Naoki Ishiguro, Toshihisa Kojima
OBJECTIVE: This study aimed to investigate predictors of biologic discontinuation due to insufficient response as a surrogate for relapse in patients with rheumatoid arthritis (RA) who achieved clinical remission with biologic treatment. METHODS: This study was performed based on data from a multicenter registry, and included 404 patients who achieved clinical remission within the first year of treatment with their first biologic. Cumulative retention rate of the first biologic was estimated using Kaplan-Meier curves, and the impact of patient characteristics on biologic discontinuation was assessed with Cox proportional hazards models...
July 13, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28696805/relevance-of-p-glycoprotein-on-cxcr4-b-cells-to-organ-manifestation-in-highly-active-rheumatoid-arthritis
#18
Shizuyo Tsujimura, Tomoko Adachi, Kazuyoshi Saito, Akio Kawabe, Yoshiya Tanaka
INTRODUCTION: In rheumatoid arthritis (RA), P-glycoprotein (P-gp) expression on activated B cells is associated with active efflux of intracellular drugs, resulting in drug resistance. CXCR4 is associated with migration of B cells. This study was designed to elucidate the relevance of P-gp expression on CXCR4(+) B cells to clinical manifestations in refractory RA. METHODS: CD19(+) B cells were analyzed using flow cytometry and immunohistochemistry. RESULTS: P-gp was highly expressed especially on CXCR4(+)CD19(+) B cells in RA...
July 11, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28696798/severer-lupus-erythematosus-like-skin-lesions-in-mrl-lpr-mice-with-homozygous-kit-wsh-wsh-mutation
#19
Yutaka Inaba, Nobuo Kanazawa, Takashi Yoshimasu, Toshio Shimokawa, Mizuho Nosaka, Toshikazu Kondo, Fukumi Furukawa
OBJECTIVE: To clarify the roles of mast cells (MCs) on the pathogenesis of lupus erythematosus (LE)-like skin lesions on MRL/lpr mice. METHODS: MRL/lpr mice were mated with C57BL/6-Kit(wsh/wsh) mice and the heterozygous F1 mice were 10 times backcrossed with the parental MRL/lpr to generate MRL/lpr-Kit(wsh/wsh) mice. MC-deficient MRL/lpr-Kit(wsh/wsh) mice were compared with MRL/lpr-Kit(+/+) and MRL/lpr-Kit(wsh/+) mice with intact MCs. RESULTS: MRL/lpr-Kit(wsh/wsh) mice developed skin lesions without infiltrating MCs...
July 11, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28696795/decoy-receptor-3-down-regulates-centrosomal-protein-70%C3%A2-kda-specifically-in-rheumatoid-synovial-fibroblasts
#20
Koji Fukuda, Yasushi Miura, Toshihisa Maeda, Shinya Hayashi, Ryosuke Kuroda
OBJECTIVES: Decoy receptor 3 (DcR3) competitively binds to Fas ligand, lymphotoxin-related inducible ligand that competes for glycoprotein D binding to herpes virus entry mediator on T cells (LIGHT) and TNF-like ligand 1A (TL1A), thereby preventing their effects. Using a microarray assay, we previously newly identified centrosomal protein 70 kDa (CEP70) as one of the genes whose expression in fibroblast-like synoviocytes from patients with rheumatoid arthritis (RA-FLS) is reduced by DcR3...
July 11, 2017: Modern Rheumatology
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