journal
MENU ▼
Read by QxMD icon Read
search

Modern Rheumatology

journal
https://www.readbyqxmd.com/read/28094589/leucine-rich-%C3%AE-2-glycoprotein-as-the-acute-phase-reactant-to-detect-systemic-juvenile-idiopathic-arthritis-disease-activity-during-anti-interleukin-6-blockade-therapy-a-case-series
#1
Masaki Shimizu, Yasuo Nakagishi, Natsumi Inoue, Mao Mizuta, Akihiro Yachie
OBJECTIVES: To assess the role of leucine-rich α2-glycoprotein (LRG) as a biomarker for monitoring systemic juvenile idiopathic arthritis (s-JIA) disease activity during interleukin (IL)-6 blockade treatment. METHODS: We serially measured serum LRG levels in four s-JIA patients treated with the anti-IL-6 receptor antibody tocilizumab and determined the correlation between clinical symptoms and other inflammatory biomarkers and proinflammatory cytokines, including IL-18, IL-6, neopterin, and tumor necrosis factor-α receptor type I and II...
January 17, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28064541/the-role-of-ifi35-in-lupus-nephritis-and-related-mechanisms
#2
Lihua Zhang, Honglin Zhu, Yisha Li, Xiaodan Dai, Bin Zhou, Quanzhen Li, Xiaoxia Zuo, Hui Luo
OBJECTIVES: It's reported that multiple genes in the IFN-γ/STAT1 pathway were hypomethylated and associated with the pathogenesis of lupus nephritis (LN). Our previous study using microarray analysis suggested that interferon induced 35-kDa protein (IFI35) was hypomethylated and increased in LN. However, the role of IFI35 in LN and related mechanism remains to be elucidate. METHODS: The expressions of IFNγR, STAT1, IFI35 and MBD2 in the human kidneys tissues was detected by real-time PCR and western blot...
January 9, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28051887/autoimmunity-as-a-trigger-for-structural-bone-damage-in-rheumatoid-arthritis
#3
Georg Schett
Bone loss is a central feature of rheumatoid arthritis (RA). It is considered to represent a sign of irreversible structural damage triggered by chronic inflammation. Recent evidence, however, suggests that autoantibodies are an important and earlier driver for bone damage in RA. This article summarizes current evidence for the role of RA-related autoantibodies in mediating bone loss. Rheumatoid factor and antibodies recognizing modified (citrullinated) proteins are the central features of autoimmunity in RA patients...
January 9, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28058962/short-term-effect-of-ultrasound-guided-low-molecular-weight-hyaluronic-acid-injection-on-clinical-outcomes-and-imaging-changes-in-patients-with-rheumatoid-arthritis-of-the-ankle-and-foot-joints-a-randomized-controlled-pilot-trial
#4
Chien-Chih Wang, Si-Huei Lee, Hsiao-Yi Lin, Fu-Wei Liu, Hong-Jen Chiou, Rai-Chi Chan, Chen-Liang Chou
To determine whether hyaluronic acid (HA) injection into rheumatoid arthritis ankles and feet can achieve improvement in foot function and reduce synovial hyper-vascularization. Forty-four patients with RA having unilateral or bilateral painful ankle and foot involvement (N = 75) were studied. All the patients were randomized to receive HA (N = 40) or lidocaine (LI) (N = 35) injection at 2-week intervals; Clinical assessments were performed using a visual analog scale (VAS) and foot function index (FFItotal) including subscales of pain (FFIpain) before injection at baseline, 4 weeks (first evaluation) and 12 weeks (secondary evaluation)...
January 6, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28058863/what-should-clinicians-know-about-the-use-of-glucocorticoids-in-systemic-sclerosis
#5
Michele Iudici
Glucocorticoids (GC) are drugs largely used by rheumatologists, but their utilization in systemic sclerosis (SSc) is still controversial for both the lack of evidence of their usefulness and the physicians and patients' concern about their related adverse events. Due to the rarity and the complexity of the disease, few studies investigating the role of GC in SSc have been performed. Thus, a huge variability in corticosteroid prescriptive practice among physicians involved in the care of SSc patients still exists worldwide...
January 6, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28049385/anti-cyclic-citrullinated-glucose-6-phosphate-isomerase-peptide-7-ccg-7-antibodies-were-suppressed-by-biologics-treatment-and-deposited-to-citrullinated-proteins-in-cd68-positive-cells-in-the-ra-synovium
#6
Naoto Umeda, Isao Matsumoto, Yuki Tanaka, Hoshimi Kawaguchi, Hiroshi Ebe, Yayoi Kagami, Akihito Ishigami, Takayuki Sumida
No abstract text is available yet for this article.
January 4, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/27919199/predictive-factors-associated-with-the-progression-of-large-joint-destruction-in-patients-with-rheumatoid-arthritis-after-biologic-therapy-a-post-hoc-analysis-using-fdg-pet-ct-and-the-arashi-assessment-of-rheumatoid-arthritis-by-scoring-of-large-joint-destruction
#7
Takahito Suto, Yukio Yonemoto, Koichi Okamura, Chisa Okura, Tetsuya Kaneko, Tsutomu Kobayashi, Masahiro Tachibana, Yoshito Tsushima, Kenji Takagishi
OBJECTIVE: To investigate the associations between large-joint damage and findings on fluorodeoxyglucose positron emission tomography combined with computed tomography (FDG-PET/CT) using the "assessment of rheumatoid arthritis by scoring of large-joint destruction and healing in radiographic imaging (ARASHI)" scoring system. METHODS: A total of 270 large joints (shoulders, elbows, hips, knees, and ankles) in 27 rheumatoid arthritis patients were assessed. FDG-PET/CT was performed at the initiation of biologics...
December 23, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27919196/the-prevalence-of-spondyloarthropathy-in-fibromyalgia-patients
#8
Derya Kaşkari, Ahmet Eftal Yücel, Muhteşem Ağildere
OBJECTIVE: To document the prevalence of Spondyloarthropathy (SpA) with an evaluation of patients previously diagnosed with fibromyalgia syndrome (FMS). METHODS: The patients diagnosed with FMS before telephoned and asked three questions to determine for inflammatory back pain. American College of Rheumatology (ACR) Fibromyalgia criteria 1990 and ACR 2010 and for diagnosing patients with SpA; criteria from the European Spondyloarthropathy Study Group (ESSG), and Amor were applied...
December 23, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27846745/a-disintegrin-and-metalloproteinase-adam-10-as-a-predictive-factor-for-tocilizumab-effectiveness-in-rheumatoid-arthritis
#9
Takeo Isozaki, Shinichiro Nishimi, Airi Nishimi, Mayu Saito, Yusuke Miwa, Yoichi Toyoshima, Katsunori Inagaki, Tsuyoshi Kasama
OBJECTIVES: A disintegrin and metalloproteinase (ADAM)-10 is expressed in rheumatoid arthritis (RA). In this study, we focused on ADAM-10 as a predictive factor for the treatment with biologics in RA. METHODS: The levels of ADAM-10 and fractalkine/CX3CL1 in RA and healthy controls serum were measured using enzyme-linked immunosorbent assays. Fifteen patients were treated with adalimumab (ADA), and 20 patients were treated with tocilizumab (TCZ). RESULTS: ADAM-10 positively correlated with fractalkine/CX3CL1 in the sera of RA patients and was presented at a significantly higher level compared to that in normal serum (487 ± 80 pg/ml and 85 ± 33 pg/ml, respectively, p < 0...
December 23, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/28001092/familial-mediterranean-fever-with-p369s-r408q-exon3-variant-in-pyrin-presenting-as-symptoms-of-pfapa
#10
Keiko Yamagami, Tomoyuki Nakamura, Ryota Nakamura, Yusuke Hanioka, Kaori Seki, Hiroshi Chiba, Keiko Kobayashi, Kazunaga Agematsu
Familial Mediterranean fever (FMF) can be classified into typical and incomplete/atypical types. Periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) syndrome-like symptoms has been found in atypical type carrying P369S-R408Q mutations in the responsible gene MEFV. A 28-year-old female with recurrent fever and her young sisters and mother, all of whom had tonsillectomy for tonsillitis, carried heterozygous alterations involving E148Q/P369S/R408Q. A diagnosis of atypical FMF, MEFV exon3 variants with PFAPA syndrome-like symptoms, was made...
December 21, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27919207/safety-and-effectiveness-of-24-week-treatment-with-iguratimod-a-new-oral-disease-modifying-antirheumatic-drug-for-patients-with-rheumatoid-arthritis-interim-analysis-of-a-post-marketing-surveillance-study-of-2679-patients-in-japan
#11
Tsuneyo Mimori, Masayoshi Harigai, Tatsuya Atsumi, Takao Fujii, Masataka Kuwana, Hiroaki Matsuno, Shigeki Momohara, Syuji Takei, Naoto Tamura, Yoshinari Takasaki, Satoshi Ikeuchi, Satoru Kushimoto, Takao Koike
OBJECTIVE: To determine the real-world safety and effectiveness of iguratimod (IGU) for rheumatoid arthritis (RA), a 52-week, Japanese, post-marketing surveillance study was conducted. An interim analysis at week 24 was performed. METHODS: This study included all RA patients who received IGU following its introduction to the market. All adverse events (AEs) and adverse drug reactions (ADRs) were collected. Effectiveness was evaluated by the change in Disease Activity Score 28-C-reactive protein (DAS28-CRP) from baseline to week 24...
December 21, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27919205/achieving-simplified-disease-activity-index-remission-in-patients-with-active-rheumatoid-arthritis-is-associated-with-subsequent-good-functional-and-structural-outcomes-in-a-real-world-clinical-setting-under-a-treat-to-target-strategy
#12
Fumio Hirano, Waka Yokoyama, Hayato Yamazaki, Koichi Amano, Atsushi Kawakami, Taichi Hayashi, Naoto Tamura, Shinsuke Yasuda, Hiroaki Dobashi, Takao Fujii, Satoshi Ito, Yuko Kaneko, Toshihiro Matsui, Yasuaki Okuda, Kazuyoshi Saito, Fumihito Suzuki, Ryusuke Yoshimi, Ryoko Sakai, Ryuji Koike, Hitoshi Kohsaka, Nobuyuki Miyasaka, Masayoshi Harigai
OBJECTIVE: To verify predictive validity of simplified disease activity index (SDAI) remission for subsequent functional and structural outcomes in real-world clinical settings under a treat-to-target strategy (T2T). METHODS: In this multicenter, prospective cohort study, T2T was implemented in rheumatoid arthritis (RA) patients with moderate-to-high disease activity. SDAI or clinical disease activity index (CDAI) was assessed every 12 weeks, and treatment was adjusted to achieve clinical remission or low disease activity (LDA)...
December 21, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27919200/bony-ankylosis-of-the-facet-joint-of-the-cervical-spine-in-rheumatoid-arthritis-its-characteristics-and-relationship-to-the-clinical-findings
#13
Haku Iizuka, Yoichi Iizuka, Koichi Okamura, Yukio Yonemoto, Tokue Mieda, Kenji Takagishi
OBJECTIVES: The purpose of this study was to clarify the characteristics of bony ankylosis of the facet joint of the cervical spine in rheumatoid arthritis (RA) patients who required cervical spine surgery, and its relationship to the clinical findings. METHODS: Eighty consecutive RA patients with cervical spine disorder who received initial surgery were reviewed. The occurrence of bony ankylosis of the facet joint of the cervical spine was investigated using computed tomography (CT) before surgery...
December 21, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27846748/beneficial-effects-of-natural-eggshell-membrane-nem-on-multiple-indices-of-arthritis-in-collagen-induced-arthritic-rats
#14
Karen J Wedekind, Kevin J Ruff, Cindy A Atwell, Joseph L Evans, Alison M Bendele
OBJECTIVES: This study was performed to evaluate the potential efficacy of natural eggshell membrane (NEM) in collagen-induced arthritic rats, a well-established rodent model of inflammation and rheumatoid arthritis. METHODS: Rats with developing type II collagen-induced arthritis (CIA) were treated once daily by oral gavage on study days -14 to 17 with vehicle or NEM (52 mg/kg body weight). Rats were euthanized on study day 17. Efficacy was assessed by daily ankle caliper measurements, ankle diameter expressed as area under the curve (AUCd0-17), and histopathologic evaluation of ankles and knees...
December 21, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27919194/total-knee-arthroplasty-improves-both-knee-function-and-disease-activity-in-patients-with-rheumatoid-arthritis
#15
Ken Kumagai, Kengo Harigane, Yoshihiro Kusayama, Taro Tezuka, Yutaka Inaba, Tomoyuki Saito
OBJECTIVE: This study evaluated the effect of TKA with capsulosynovectomy on disease activity and knee function in patients with RA. METHODS: Seventy-six RA patients who underwent primary TKA with more than two years of follow-up were retrospectively reviewed to assess postoperative knee function and disease activity. RESULTS: Postoperative knee function was significantly improved in all clinical scores, and maintained up to 24 months after surgery...
December 16, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27846767/a-multicenter-phase-ii-prospective-clinical-trial-of-glucocorticoid-for-patients-with-untreated-igg4-related-disease
#16
Yasufumi Masaki, Shoko Matsui, Takako Saeki, Hiroto Tsuboi, Shintaro Hirata, Yasumori Izumi, Taiichiro Miyashita, Keita Fujikawa, Hiroaki Dobashi, Kentaro Susaki, Hisanori Morimoto, Kazutaka Takagi, Mitsuhiro Kawano, Tomoki Origuchi, Yoko Wada, Naoki Takahashi, Masanobu Horikoshi, Hiroshi Ogishima, Yasunori Suzuki, Takafumi Kawanami, Haruka Kawanami Iwao, Tomoyuki Sakai, Yoshimasa Fujita, Toshihiro Fukushima, Masatoshi Saito, Ritsuro Suzuki, Yuko Morikawa, Tadashi Yoshino, Shigeo Nakamura, Masaru Kojima, Nozomu Kurose, Yasuharu Sato, Yoshiya Tanaka, Susumu Sugai, Takayuki Sumida
OBJECTIVE: Although glucocorticoids are effective for patients with IgG4-related disease, the treatment has not yet been standardized. Therefore, the treatment strategy should be established. PATIENTS AND METHODS: Patients who fulfilled the comprehensive diagnostic criteria for definite IgG4-related disease were started on prednisolone (0.6 mg/kg body weight) with the dose reduced every two weeks. The subsequent maintenance dose and need for prednisolone were determined for individual patients...
December 15, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27846761/prognostic-factors-of-methotrexate-associated-lymphoproliferative-disorders-associated-with-rheumatoid-arthritis-and-plausible-application-of-biological-agents
#17
Takayuki Katsuyama, Ken-Ei Sada, Minglu Yan, Sonia Zeggar, Sumie Hiramatsu, Yoshia Miyawaki, Keiji Ohashi, Michiko Morishita, Haruki Watanabe, Eri Katsuyama, Mariko Takano-Narazaki, Noriko Toyota-Tatebe, Katsue Sunahori-Watanabe, Tomoko Kawabata, Kohei Miyake, Toru Kiguchi, Jun Wada
OBJECTIVES: To determine prognostic factors of methotrexate-associated lymphoproliferative disorder (MTX-LPD) and evaluate the efficacy and safety of biological therapy in rheumatoid arthritis (RA) complicated with MTX-LPD. METHODS: Thirty RA patients who developed MTX-LPD were investigated in this study. We compared the clinical and laboratory parameters of patients who achieved regression of LPD by MTX withdrawal with those who required chemotherapy and evaluated the clinical course of RA after LPD development...
December 15, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27846758/ankylosing-spondylitis-m-csf-derived-macrophages-are-undergoing-unfolded-protein-response-upr-and-express-higher-levels-of-interleukin-23
#18
Alireza Rezaiemanesh, Mahdi Mahmoudi, Ali Akbar Amirzargar, Mahdi Vojdanian, Ahmad Reza Jamshidi, Mohammad Hossein Nicknam
OBJECTIVE: Interleukin (IL)-23/IL-17 pathway involves in the pathogenesis of ankylosing spondylitis (AS). The exact mechanism implicated in overexpression of IL-23 and activation of the IL-23/IL-17 axis is not clear. The aim of the study was to clarify whether macrophages of AS patients undergo unfolded protein response (UPR) and secret increased IL-23. METHODS: Peripheral blood monocyte isolated from 10 HLA-B27(+) patients and five HLA-B27(+) normal subjects were differentiated to macrophages by macrophage-colony stimulating factor (M-CSF) for seven days...
December 15, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27846756/simplified-disease-activity-index-remission-at-month-6-is-an-independent-predictor-of-functional-and-structural-remissions-at-month-12-during-abatacept-treatment-in-patients-with-rheumatoid-arthritis-a-multi-center-prospective-cohort-study-in-japan
#19
Hayato Yamazaki, Fumio Hirano, Tsutomu Takeuchi, Koichi Amano, Jun Kikuchi, Mari Kihara, Waka Yokoyama, Takahiko Sugihara, Kenji Nagasaka, Hiroyuki Hagiyama, Yoshinori Nonomura, Ryoko Sakai, Michi Tanaka, Ryuji Koike, Toshihiro Nanki, Hitoshi Kohsaka, Nobuyuki Miyasaka, Masayoshi Harigai
OBJECTIVE: To evaluate association of clinical remission at month 6 with functional and structural remissions at month 12 during abatacept treatment in patients with rheumatoid arthritis (RA). METHODS: This 12-month prospective, multicenter cohort study enrolled 168 patients with RA who started abatacept. Outcomes were assessed using composite measures, quality of life indices, and the van der Heijde-modified total Sharp score (mTSS). The logistic regression analysis was applied to identify factors associated with outcomes and their odds ratios (OR) with 95% confidence interval (95% CI)...
December 15, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27846751/differential-effects-of-il-6-blockade-tocilizumab-and-tnf-inhibitors-on-angiogenesis-in-synovial-tissues-from-patients-with-rheumatoid-arthritis
#20
Shunsei Hirohata, Asami Abe, Akira Murasawa, Toshihisa Kanamono, Tetsuya Tomita, Hideki Yoshikawa
OBJECTIVE: To compare the influences of tocilizumab (TCZ) and TNF inhibitors (TNFi) on the angiogenesis in synovial tissues of rheumatoid arthritis (RA). METHODS: Synovial tissues were obtained during joint operations from 13 RA patients treated with TCZ for at least 4 months with or without previous use of TNFi, from 13 RA patients with TNFi alone and from 10 RA patients with only conventional synthetic DMARDs (csDMARDs). Synovial tissues were evaluated by hematoxylin and eosin stain as well as by immunohistological staining with anti-CD31 in which the microvessel densities (MVD) were quantitated...
December 15, 2016: Modern Rheumatology
journal
journal
35092
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"