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Modern Rheumatology

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https://www.readbyqxmd.com/read/27848256/successful-ledipasvir-sofosbuvir-treatment-of-active-synovitis-in-a-rheumatoid-arthritis-patient-with-hepatitis-c-virus-related-mixed-cryoglobulinemia
#1
Tomohiro Koga, Shin-Ya Kawashiri, Kazuhiko Nakao, Atsushi Kawakami
No abstract text is available yet for this article.
November 16, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27846770/the-relationship-between-balance-and-vitamin-25-oh-d-in-fibromyalgia-patients
#2
Meliha Kasapoğlu Aksoy, Lale Altan, Burcu Ökmen Metin
: INTRODUCTİON: Fibromyalgia syndrome (FMS) is a chronic disease characterized by diffuse pain of unknown cause, fatigue, sleep disorders, cognitive dysfunction and sensitivity. Fibromyalgia was shown to be associated with balance problems and increased incidence of falls. There are many theoretical mechanisms related to the impact of vitamin D on postural control. The aim of the current study was to investigate the relationship between vitamin 25(OH)D levels and pain, balance and daily activities in patients with FMS...
November 16, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27846767/a-multicenter-phase-ii-prospective-clinical-trial-of-glucocorticoid-for-patients-with-untreated-igg4-related-disease
#3
Yasufumi Masaki, Shoko Matsui, Takako Saeki, Hiroto Tsuboi, Shintaro Hirata, Yasumori Izumi, Taiichiro Miyashita, Keita Fujikawa, Hiroaki Dobashi, Kentaro Susaki, Hisanori Morimoto, Kazutaka Takagi, Mitsuhiro Kawano, Tomoki Origuchi, Yoko Wada, Naoki Takahashi, Masanobu Horikoshi, Hiroshi Ogishima, Yasunori Suzuki, Takafumi Kawanami, Haruka Iwao Kawanami, Tomoyuki Sakai, Yoshimasa Fujita, Toshihiro Fukushima, Masatoshi Saito, Ritsuro Suzuki, Yuko Morikawa, Tadashi Yoshino, Shigeo Nakamura, Masaru Kojima, Nozomu Kurose, Yasuharu Sato, Yoshiya Tanaka, Susumu Sugai, Takayuki Sumida
"Objective" Although glucocorticoids are effective for patients with IgG4-related disease, the treatment has not yet been standardized. Therefore, the treatment strategy should be established. "Patients and methods" Patients who fulfilled the comprehensive diagnostic criteria for definite IgG4-related disease were started on prednisolone (0.6mg/kg body weight) with the dose reduced every 2 weeks. The subsequent maintenance dose and need for prednisolone were determined for individual patients. The primary endpoint was the complete remission (CR) rate at 1 year...
November 16, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27846766/comparison-of-a-self-administered-foot-evaluation-questionnaire-safe-q-between-joint-preserving-arthroplasty-and-resection-replacement-arthroplasty-in-forefoot-surgery-for-patients-with-rheumatoid-arthritis
#4
Kosuke Ebina, Makoto Hirao, Jun Hashimoto, Akihide Nampei, Kenrin Shi, Tetsuya Tomita, Kazuma Futai, Yasuo Kunugiza, Takaaki Noguchi, Hideki Yoshikawa
OBJECTIVES: To clarify the difference of patient-based outcome between joint-preserving arthroplasty and resection-replacement arthroplasty in forefoot surgery for patients with rheumatoid arthritis (RA). METHODS: A total of 63 feet of 49 RA patients who underwent forefoot surgery were asked to answer pre-operative and post-operative self-administered foot evaluation questionnaire (SAFE-Q). Patients were treated with either (1) metatarsal head resection-replacement arthroplasty (28 feet, post-operative mean age 63...
November 16, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27846765/adult-onset-still-s-disease-like-manifestation-accompanied-by-the-cancer-recurrence-after-long-term-resting-state
#5
Kazuhito Fukuoka, Ayako Miyamoto, Yuko Ozawa, Noriko Ikegaya, Tomohiro Maesono, Yoshinori Komagata, Shinya Kaname, Yoshihiro Arimura
A 72-year-old woman presented nine months ago with skin rash on her bilateral forearms, which was followed by intermittent high fever, and stiffness and swelling of her bilateral fingers. She was diagnosed with seronegative rheumatoid arthritis (RA). She had a past history of breast cancer and had undergone breast preservation surgery 13 years previously. During admission in our hospital, she developed high fever and leukocytosis with a relapsing skin rash, sore throat, polyarthralgia and increased levels of serum ALT/AST and ferritin, all of which fulfilled Yamaguchi's criteria for adult-onset Still's disease (AOSD)...
November 16, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27846761/prognostic-factors-of-methotrexate-associated-lymphoproliferative-disorders-associated-with-rheumatoid-arthritis-and-plausible-application-of-biological-agents
#6
Takayuki Katsuyama, Ken-Ei Sada, Minglu Yan, Sonia Zeggar, Sumie Hiramatsu, Yoshia Miyawaki, Keiji Ohashi, Michiko Morishita, Haruki Watanabe, Eri Katsuyama, Mariko Takano-Narazaki, Noriko Toyota-Tatebe, Katsue Sunahori-Watanabe, Tomoko Kawabata, Kohei Miyake, Toru Kiguchi, Jun Wada
OBJECTIVES: To determine prognostic factors of methotrexate-associated lymphoproliferative disorder (MTX-LPD) and evaluate the efficacy and safety of biological therapy in rheumatoid arthritis (RA) complicated with MTX-LPD. METHODS: Thirty RA patients who developed MTX-LPD were investigated in this study. We compared the clinical and laboratory parameters of patients who achieved regression of LPD by MTX withdrawal with those who required chemotherapy and evaluated the clinical course of RA after LPD development...
November 16, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27846758/ankylosing-spondylitis-m-csf-derived-macrophages-are-undergoing-unfolded-protein-response-upr-and-express-higher-levels-of-interleukin-23
#7
Alireza Rezaiemanesh, Mahdi Mahmoudi, Ali Akbar Amirzargar, Mahdi Vojdanian, Ahmad Reza Jamshidi, Mohammad Hossein Nicknam
OBJECTIVE: Interleukin (IL)-23/IL-17 pathway involves in the pathogenesis of ankylosing spondylitis (AS). The exact mechanism implicated in overexpression of IL-23 and activation of the IL-23/IL-17 axis is not clear. The aim of the study was to clarify whether macrophages of AS patients undergo unfolded protein response (UPR) and secret increased IL-23. METHODS: Peripheral blood monocyte isolated from 10 HLA-B27(+) patients and 5 HLA-B27(+) normal subjects were differentiated to macrophages by macrophage-colony stimulating factor (M-CSF) for 7 days...
November 16, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27846756/simplified-disease-activity-index-remission-at-month-6-is-an-independent-predictor-of-functional-and-structural-remissions-at-month-12-during-abatacept-treatment-in-patients-with-rheumatoid-arthritis-a-multi-center-prospective-cohort-study-in-japan
#8
Hayato Yamazaki, Fumio Hirano, Tsutomu Takeuchi, Koichi Amano, Jun Kikuchi, Mari Kihara, Waka Yokoyama, Takahiko Sugihara, Kenji Nagasaka, Hiroyuki Hagiyama, Yoshinori Nonomura, Ryoko Sakai, Michi Tanaka, Ryuji Koike, Toshihiro Nanki, Hitoshi Kohsaka, Nobuyuki Miyasaka, Masayoshi Harigai
OBJECTIVE: To evaluate association of clinical remission at month 6 with functional and structural remissions at month 12 during abatacept treatment in patients with rheumatoid arthritis (RA). METHODS: This 12-month prospective, multicenter cohort study enrolled 168 patients with RA who started abatacept. Outcomes were assessed using composite measures, quality of life indices, and the van der Heijde-modified total Sharp score (mTSS). The logistic regression analysis was applied to identify factors associated with outcomes and their odds ratios (OR) with 95% confidence interval (95% CI)...
November 16, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27846755/primary-varicella-infection-in-children-with-systemic-juvenile-idiopathic-arthritis-under-tocilizumab-therapy
#9
Tomo Nozawa, Kenichi Nishimura, Asami Ohara, Ryoki Hara, Shuichi Ito
We report the clinical course and outcome of primary varicella infection in six children with systemic juvenile idiopathic arthritis (sJIA) receiving tocilizumab. None had disseminated or fatal varicella infection, but one patient developed macrophage activation syndrome (MAS) and another had an arthritis relapse. All patients had a significant elevation of serum IL-6 levels, and the two children who developed MAS or arthritis relapse showed high serum IL-18 levels, which could cause a sJIA flare-up.
November 16, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27846751/differential-effects-of-il-6-blockade-tocilizumab-and-tnf-inhibitors-on-angiogenesis-in-synovial-tissues-from-patients-with-rheumatoid-arthritis
#10
Shunsei Hirohata, Asami Abe, Akira Murasawa, Toshihisa Kanamono, Tetsuya Tomita, Hideki Yoshikawa
OBJECTIVE: To compare the influences of tocilizumab (TCZ) and TNF inhibitors (TNFi) on the angiogenesis in synovial tissues of rheumatoid arthritis (RA). METHODS: Synovial tissues were obtained during joint operations from 13 RA patients treated with TCZ for at least 4 months with or without previous use of TNFi, from 13 RA patients with TNFi alone and from 10 RA patients with only conventional synthetic DMARDs (csDMARDs). Synovial tissues were evaluated by hematoxylin and eosin stain as well as by immunohistological staining with anti-CD31 in which the microvessel densities (MVD) were quantitated...
November 16, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27846750/survey-on-attitudes-regarding-eular-recommendations-for-the-role-of-nurses-involved-in-medical-care-of-patients-with-chronic-inflammatory-arthritis-in-japan
#11
Mie Fusama, Hideko Nakahara, Yvonne van Eijk-Hustings, Susan Oliver, Tsutomu Takeuchi
OBJECTIVE: We seek to evaluate the opinions of nurses and doctors in Japan regarding EULAR recommendations for nurses' roles in the management of chronic inflammatory arthritis. METHODS: This is a cross-sectional survey within Japan. We randomly selected nurses and doctors engaged in consultation of patients with rheumatoid arthritis (RA) and assessed their agreement and opinions on the feasibility of implementing EULAR recommendations, including potential barriers...
November 16, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27846749/synovitis-of-sternoclavicular-and-peripheral-joints-can-be-detected-by-ultrasound-in-patients-with-sapho-syndrome
#12
Masataka Umeda, Shin-Ya Kawashiri, Ayako Nishino, Tomohiro Koga, Kunihiro Ichinose, Toru Michitsuji, Toshimasa Shimizu, Shoichi Fukui, Yoshikazu Nakashima, Yasuko Hirai, Naoki Iwamoto, Toshiyuki Aramaki, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Yukitaka Ueki, Atsushi Kawakami
OBJECTIVES: To determine the prevalence of ultrasonographic abnormalities of sternoclavicular joints (SCJ) and peripheral joints (PJ) in patients with synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome. METHODS: Thirteen patients with SAPHO syndrome who fulfilled diagnostic criteria proposed by Kahn for SAPHO syndrome 2003 and 13 healthy individuals age- and sex-matched were enrolled. Synovitis, defined by synovial hypertrophy with power Doppler (PD) signals, of the SCJ and the PJ including wrist, MCP, PIP and the other symptomatic joints were evaluated by ultrasound (US)...
November 16, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27846748/beneficial-effects-of-natural-eggshell-membrane-nem-on-multiple-indices-of-arthritis-in-collagen-induced-arthritic-rats
#13
Karen J Wedekind, Kevin J Ruff, Cindy A Atwell, Joseph L Evans, Alison M Bendele
OBJECTIVES: This study was performed to evaluate the potential efficacy of natural eggshell membrane (NEM) in collagen-induced arthritic rats, a well-established rodent model of inflammation and rheumatoid arthritis. METHODS: Rats with developing type II collagen-induced arthritis (CIA) were treated once daily by oral gavage on study days -14 to 17 with vehicle or NEM (52 mg/kg body weight). Rats were euthanized on study day 17. Efficacy was assessed by daily ankle caliper measurements, ankle diameter expressed as area under the curve (AUCd0-17), and histopathologic evaluation of ankles and knees...
November 16, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27846747/a-case-of-alopecia-as-igg4-related-skin-disease
#14
Takaharu Ikeda, Chikako Kaminaka, Fukumi Furukawa
A 53-year-old man with autoimmune pancreatitis as IgG4-related disease presented alopecia. Immunostaining showed perifollicular infiltration of IgG4-positive cells and perifollicular/intrafollicular infiltration of predominantly CD4-positive cells especially in the upper and lower parts. Alopecia areata is characterized by perifollicular/intrafollicular lymphocyte infiltration of the lower bulb and inflammation in the upper dermis. We determined the patient had IgG4-related skin disease, rather than alopecia areata...
November 16, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27846746/minimum-10-year-results-of-cementless-total-hip-arthroplasty-in-patients-with-rheumatoid-arthritis
#15
Akihisa Haraguchi, Yasuharu Nakashima, Hisaaki Miyahara, Yukio Esaki, Ken Okazaki, Jun-Ichi Fukushi, Go Hirata, Satoshi Ikemura, Satoshi Kamura, Koji Sakuraba, Kenjiro Fujimura, Yukio Akasaki, Hisakata Yamada
OBJECTIVES: To retrospectively evaluate the long-term results of cementless total hip arthroplasty (THA) in patients with rheumatoid arthritis (RA) and postoperative patient mortality after THA. METHODS: This study included 191 hips in 149 RA patients who underwent cementless THA between 1998 and 2005. Mean age at surgery was 54.2 years, and mean follow-up was 12.6 years. Implant and patient survivorships were determined using the Kaplan-Meier method, and the associated influencing factors were determined...
November 16, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27846745/a-disintegrin-and-metalloproteinase-adam-10-as-a-predictive-factor-for-tocilizumab-effectiveness-in-rheumatoid-arthritis
#16
Takeo Isozaki, Shinichiro Nishimi, Airi Nishimi, Mayu Saito, Yusuke Miwa, Yoichi Toyoshima, Katsunori Inagaki, Tsuyoshi Kasama
OBJECTIVES: A disintegrin and metalloproteinase (ADAM)-10 is expressed in rheumatoid arthritis (RA). In this study, we focused on ADAM-10 as predictive factor for treatment with biologics in RA. METHODS: The levels of ADAM-10 and fractalkine/CX3CL1 in RA and healthy controls serum were measured with enzyme-linked immunosorbent assays. Fifteen patients were treated with adalimumab (ADA), and 20 patients were treated with tocilizumab (TCZ). RESULTS: ADAM-10 positively correlated with fractalkine/CX3CL1 in the sera of RA patients and was present at a significantly higher level compared to that in normal serum (487±80 pg/ml and 85±33 pg/ml, respectively, p < 0...
November 16, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27846744/a-case-of-rheumatoid-vasculitis-with-acquired-reactive-perforating-collagenosis
#17
Takaharu Ikeda, Naoya Mikita, Fukumi Furukawa, Yoshifumi Iwahashi
A 55-year-old man with rheumatoid arthritis presented hyperkeratotic erythematous papules with crusts or blisters on his limbs and buttocks. A histological study showed acquired reactive perforating collagenosis. Soon, skin lesions changed to umbilicated lesions with black necrosis, and the scar from his skin biopsy ulcerated with induration due to rheumatoid vasculitis. Systemic corticosteroids and tacrolimus administration resolved the rheumatoid arthritis and skin lesions. Rheumatoid vasculitis with acquired reactive perforating collagenosis has not been reported previously...
November 16, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27830970/assessment-of-both-articular-synovitis-and-tenosynovitis-by-ultrasound-is-useful-for-evaluations-of-hand-dysfunction-in-early-rheumatoid-arthritis-patients
#18
Ayako Nishino, Shin-Ya Kawashiri, Toshimasa Shimizu, Masataka Umeda, Shoichi Fukui, Tomohiro Koga, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Yasuhiro Nagata, Takahiro Maeda, Kiyoshi Aoyagi, Atsushi Kawakami
OBJECTIVES: We investigated the association between hand dysfunction and ultrasound (US)-detected articular synovitis and tenosynovitis in patients with rheumatoid arthritis (RA). METHODS: Thirty RA patients were examined. In both hands of all subjects, articular synovitis and tenosynovitis were assessed by US at 22 joints and 12 tendons. Each joint and tendon was scored by gray-scale (GS) and power Doppler (PD) on a scale from 0 to 3. The sums of the GS or PD scores were used as the articular synovitis score and the tenosynovitis score...
November 15, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27841698/corrigendum
#19
(no author information available yet)
No abstract text is available yet for this article.
November 14, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27830969/plasmapheresis-therapy-in-combination-with-tnf-%C3%AE-inhibitor-and-dmards-a-multi-target-method-for-treatment-of-rheumatoid-arthritis
#20
Yongjing Cheng, Feng Yang, Cibo Huang, Jia Huang, Qian Wang, Yingjuan Chen, Yingjue Du, Like Zhao, Ming Gao, Fang Wang
OBJECTIVE: To evaluate the effects of a multi-target method involving plasmapheresis therapy combined with tumor necrosis factor (TNF)-α inhibitor and disease-modifying anti-rheumatic drugs (DMARDs) on disease activity parameters in the treatment of active rheumatoid arthritis (RA). METHODS: Sixty-five patients with active RA were divided into 2 groups according to treatment administered: the plasmapheresis combination therapy group (Plasmapheresis combination group; 38 cases), in which patients received plasmapheresis therapy along with a TNF-α inhibitor (recombinant human tumor necrosis factor-Fc; rhTNFR:Fc; Etanercept biosimilars) and DMARDs, and a TNF-α inhibitor therapy group (biological agent group; 27 cases), in which patients received a TNF-α inhibitor and DMARDs...
November 10, 2016: Modern Rheumatology
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