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Modern Rheumatology

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https://www.readbyqxmd.com/read/30221573/real-world-effectiveness-and-safety-of-adalimumab-for-treatment-of-ankylosing-spondylitis-in-japan
#1
Shigeto Kobayashi, Tomoko Kashiwagi, Junko Kimura
OBJECTIVE: To evaluate the real-world effectiveness and safety of adalimumab for the treatment of ankylosing spondylitis (AS) in Japan. METHODS: All AS patients initiated on adalimumab from 27 October 2010 to 28 May 2015, were enrolled. Patient characteristics at baseline, changes in Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) scores, and adverse drug reactions (ADRs) for 24 weeks from the first adalimumab treatment were evaluated. RESULTS: Of 403 enrolled patients, 396 and 374 comprised the safety and effectiveness analysis sets, respectively...
November 1, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/30175668/evaluation-of-factors-associated-with-locomotive-syndrome-in-japanese-elderly-and-younger-patients-with-rheumatoid-arthritis
#2
Takeshi Mochizuki, Katsunori Ikari, Koichiro Yano, Ken Okazaki
OBJECTIVES: We aimed to determine the prevalence of locomotive syndrome (LS) using the 25-question geriatric locomotive function scale (GLFS-25) and identify factors associated with LS in elderly and younger patients with rheumatoid arthritis (RA). METHODS: Overall, 390 patients with RA who underwent GLFS-25 measurement, bone mineral density determination, and bioelectrical impedance analysis were enrolled. Factors associated with LS were analyzed by comparing patients with and without LS among both elderly and younger patients with RA...
November 1, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/30379089/validation-of-the-fibrosis-4-fib-4-index-in-the-diagnosis-of-liver-disease-of-rheumatoid-arthritis-patients-treated-with-methotrexate
#3
Masayuki Miyata, Masahito Kuroda, Masamitsu Unakami, Kazuhiro Tasaki, Kiyoshi Migita, Hiromasa Ohira
Objectives To validate the usefulness of a hepatic fibrosis scoring system fibrosis-4 (FIB-4) index to diagnose liver diseases in rheumatoid arthritis (RA) patients treated with methotrexate (MTX). Methods The FIB-4 index (age(years) × AST(U/L)/platelet (PLT) (109 /L) × √ALT(U/L)), proposed as a predictor for liver fibrosis in HIV/HCV coinfection, was evaluated in this study. RA patients on MTX treatment were screened by FIB-4 index values to detect fibrotic change in the liver. Liver biopsy specimens were examined histologically in patients with high values...
October 31, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/30126298/clinical-practice-guidance-for-juvenile-idiopathic-arthritis-jia-2018
#4
Nami Okamoto, Shumpei Yokota, Syuji Takei, Yuka Okura, Tomohiro Kubota, Masaki Shimizu, Tomo Nozawa, Naomi Iwata, Hiroaki Umebayashi, Noriko Kinjo, Tomoko Kunishima, Junko Yasumura, Masaaki Mori
Juvenile idiopathic arthritis (JIA) is the most common disease in pediatric rheumatism. There is no specific symptom or examination finding for JIA, and the diagnosis is made by exclusion and differentiation. Because non-pediatric rheumatologists are sometimes involved in medical care, 'proposal for JIA guidance on diagnosis and treatment for primary care pediatricians and non-pediatric rheumatologists' was first published in 2007. In these 10 years, a number of new findings on pathophysiology and treatment of JIA have been published; therefore, we propose this guidance of 2018th edition aiming at updating and standardization of JIA medical care in Japan...
October 29, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29943671/cigarette-smoking-and-risk-of-behcet-s-disease-a-propensity-score-matching-analysis
#5
Aida Malek Mahdavi, Alireza Khabbazi, Barmak Yaaghoobian, Morteza Ghojazadeh, Ramin Agamohammadi, Atefeh Kheyrollahiyan, Nadereh Rashtchizadeh
OBJECTIVE: Behcet's disease (BD) is an inflammatory disease and smoking may have a role in its triggering. This case-control study was conducted to investigate the association between smoking and the risk of BD. METHODS: We included 192 patients with BD and 822 healthy siblings of patient with BD and 373 healthy unrelated persons as control groups. Demographic data and smoking history of patients and their siblings were obtained by direct and in some cases by telephone interview with the participants...
October 29, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/30354922/interleukin-5-producing-st2-memory-th2-cells-in-igg4-related-dacryoadenitis-and-sialadenitis
#6
Motohisa Yamamoto, Ken-Ichi Takano, Ryuta Kamekura, Satsuki Aochi, Chisako Suzuki, Shingo Ichimiya, Hiroshi Nakase, Tetsuo Himi, Hiroki Takahashi
OBJECTIVES: Immunoglobulin (Ig) G4-related disease (IgG4-RD) is often complicated by allergic disorders. This study was conducted to investigate the mechanism of type 2 helper T-inflammation (Th2-inflammation) in IgG4-related dacryoadenitis and sialadenitis (IgG4-DS). METHODS: We separated and analyzed the proportion of growth stimulation expressed gene 2 (ST2)+ memory Th2 cells among the peripheral blood mononuclear cells by flow cytometry in cases with IgG4-DS and healthy individuals...
October 25, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/30246572/the-time-sequential-changes-of-risk-factors-for-adult-t-cell-leukemia-development-in-human-t-cell-leukemia-virus-positive-patients-with-rheumatoid-arthritis-a-retrospective-cohort-study
#7
Kunihiko Umekita, Yayoi Hashiba, Yumi Kariya, Kazuyoshi Kubo, Shunichi Miyauchi, Ayako Aizawa, Kazumi Umeki, Hajime Nomura, Takeshi Kawaguchi, Motohiro Matsuda, Ichiro Takajo, Toshihiko Hidaka, Akihiko Okayama
OBJECTIVE: This study aimed to investigate the time-sequential changes of risk factors for adult T-cell leukemia (ATL) development in human T-cell leukemia virus type 1 (HTLV-1)-positive rheumatoid arthritis (RA) patients. METHODS: HTLV-1 infection was screened using particle agglutination assay and confirmed via western blotting in 365 RA patients. Twenty-three HTLV-1-positive RA patients were included in the study cohort. Blood samples were obtained from these patients at each observation time point...
October 25, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/30217121/involvement-of-midkine-in-autoimmune-and-autoinflammatory-diseases
#8
Ahmet Şükrü Aynacıoğlu, Ayhan Bilir, Mehmet Yakup Tuna
Midkine (MK) is a heparin-binding growth factor that markedly expressed during embryogenesis but downregulated to inconsiderable levels in healthy adults. However, MK is upregulated during tissue repair and in many pathologic conditions, mostly malignancies and inflammatory diseases. MK promotes a number of functions in target cells such as migration, proliferation, survival, growth, reproduction and repair, angiogenesis, and gene expression. It acts as a pro-inflammatory cytokine and contributes to chronic inflammation via promoting chemotaxis and tissue infiltration of neutrophils and macrophages...
October 25, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/30217117/safety-and-effectiveness-of-abatacept-in-japanese-non-elderly-and-elderly-patients-with-rheumatoid-arthritis-in-an-all-cases-post-marketing-surveillance
#9
Masayoshi Harigai, Naoki Ishiguro, Shigeko Inokuma, Tsuneyo Mimori, Junnosuke Ryu, Syuji Takei, Tsutomu Takeuchi, Yoshiya Tanaka, Yoshinari Takasaki, Hisashi Yamanaka, Yuri Yoshizawa, Ichino Chinen, Toru Nakao, Takao Koike
OBJECTIVES: To investigate the safety, effectiveness, and risk-benefit balance of intravenous abatacept (ABA) in non-elderly (<65 years: NEG) and elderly (≥65 years: EG) rheumatoid arthritis patients. METHODS: This sub-analysis of an all-cases postmarketing surveillance in Japan assessed safety in all enrolled patients and effectiveness in those with Disease Activity Score 28 based on C-reactive protein (DAS28-CRP) measurements at ≥2 time points including baseline...
October 25, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/30334661/drug-survival-rates-of-biological-disease-modifying-antirheumatic-drugs-and-janus-kinase-inhibitor-therapy-in-801-rheumatoid-arthritis-patients-a-14-year-retrospective-study-from-a-rheumatology-clinic-in-japan
#10
Masakazu Kondo, Hisakata Yamada
OBJECTIVES: To assess long-term outcomes for 7 biological disease-modifying antirheumatic drugs (bDMARDs) and one Janus kinase (JAK)-inhibitor in rheumatoid arthritis. METHODS: We retrospectively analyzed data from 801 rheumatoid arthritis patients visiting our rheumatology clinic between 2003 and 2017. We determined drug survival rates, drug discontinuation, and switching rates in these patients. RESULTS: Among the drugs administered to naïve subjects, the drug-survival rate was highest for tocilizumab, at 77...
October 18, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/30334639/safety-and-efficacy-of-verinurad-a-selective-urat1-inhibitor-for-the-treatment-of-patients-with-gout-and-or-asymptomatic-hyperuricemia-in-the-united-states-and-japan-findings-from-two-phase-ii-trials
#11
David Fitz-Patrick, Kent Roberson, Kiyoshi Niwa, Takabumi Fujimura, Koji Mori, Jesse Hall, Xiaohong Yan, Zancong Shen, Sha Liu, Yasushi Ito, Scott Baumgartner
OBJECTIVE: Evaluate efficacy/safety of verinurad monotherapy in patients with gout (Japan/US) or asymptomatic hyperuricemia (Japan). METHODS: Two randomized, placebo-controlled, phase II studies were conducted (NCT01927198/NCT02078219). Patients were randomized to once-daily doses of placebo or escalating doses of verinurad (study 1: 5-12.5 mg; study 2: 2.5-15 mg). Primary endpoint was percentage change from baseline in serum urate (sUA) at week 12 (study 1)/week 16 (study 2)...
October 18, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/30334638/association-of-hyperuricemia-and-pulmonary-hypertension-a-systematic-review-and-meta-analysis
#12
Tae Uk Kang, Kyu Yong Park, Hyun Jung Kim, Hyeong Sik Ahn, Shin-Young Yim, Jae-Bum Jun
OBJECTIVES: To investigate the association of hyperuricemia with pulmonary hypertension (PH) in term of subsequent development, severity, and prognosis of PH. METHODS: The authors systematically reviewed articles from databases and conducted meta-analyses as follows: (1) association of serum uric acid (UA) levels with the presence of PH; (2) association between serum UA levels and subsequent development of PH, in terms of odds ratio of the development of PH; and (3) association of serum UA levels with severity and prognosis of PH, in terms of pulmonary arterial pressure and hazard ratio of death...
October 18, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/30334637/immunophenotype-involved-in-igg4-related-disease
#13
Satoshi Kubo, Shingo Nakayamada, Yoshiya Tanaka
As stated in the comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), IgG4-RD is characterized by elevated serum IgG4 level and pathological findings, characterized by infiltration of IgG4-positive plasma cells. In addition to fibrotic changes, dysregulated activation of lymphocytes is considered as one of major pathogenic events in IgG4-RD. Among lymphocytes, the importance of plasmablast, T follicular helper (Tfh) cells, T type 2 helper (Th2) cells, T regulatory (Treg) cells, and CD4 positive T cells with cytotoxic activity has been reported...
October 18, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/30334636/hla-b46-is-associated-with-severe-sacroiliitis-in-japanese-patients-with-psoriatic-arthritis
#14
Kyoko Ikumi, Shigeto Kobayashi, Naoto Tamura, Kurisu Tada, Hisashi Inoue, Satoshi Osaga, Emi Nishida, Akimichi Morita
OBJECTIVES: The aim of the present study was to determine if the HLA phenotype is related to severe sacroiliitis in Japanese patients with psoriatic arthritis. METHODS: This study was a single-center, retrospective, cross-sectional, observational study. We reviewed the clinical information and radiologic examinations of patients with psoriatic arthritis (PsA) who visited our hospital from January 2011 to December 2016. Radiographic changes in the sacroiliac joints were assessed by four independent investigators according to the recommendations of the Assessment of Spondyloarthritis International Society...
October 18, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/30334633/efficacy-and-safety-of-secukinumab-in-japanese-patients-with-active-ankylosing-spondylitis-24-week-results-from-an-open-label-phase-3-study-measure-2-j
#15
Mitsumasa Kishimoto, Atsuo Taniguchi, Ayako Fujishige, Shuhei Kaneko, Sibylle Haemmerle, Brian O Porter, Shigeto Kobayashi
OBJECTIVE: Secukinumab, a fully human monoclonal antibody that neutralizes interleukin-17A, improved the signs and symptoms of ankylosing spondylitis (AS) in three Phase 3 global studies (MEASURE 1, 2, and 3). Here we describe the efficacy and safety results through Week 24 of a study of secukinumab in Japanese patients with active AS. METHODS: In this multicenter, open-label, single arm, 52-week study, 30 AS patients self-administered secukinumab 150 mg subcutaneously at baseline, Weeks 1, 2, 3 and 4, and every 4 weeks thereafter...
October 18, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/30334628/swollen-joints-and-peripheral-arthritis-are-signs-of-malignancy-in-polymyalgia-rheumatica
#16
Tohru Michitsuji, Nozomi Iwanaga, Yoshiro Horai, Yoshika Tsuji, Chieko Kawahara, Yasumori Izumi, Ken Taniguchi, Shinichiro Yoshida, Atsushi Kawakami
AIM: To analyze the clinical course and prognosis in patients diagnosed with polymyalgia rheumatica (PMR) complicated by the presence of malignancies. METHODS: We retrospectively screened the case files of 216 patients hospitalized in our department between 2011 and December 2016 for the results of a thorough physical examination and data on treatment for rheumatic diseases. We identified 53 patients with PMR according to Bird's criteria and 43 patients with 2012 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) classification criteria for PMR, then analyzed the clinical and serologic manifestations of PMR in patients with (n = 6) and without (n = 47 in Bird' criteria, n = 37 in 2012 EULAR/ACR criteria) malignancy...
October 18, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/30334477/cytokines-produced-by-innate-immune-cells-in-igg4-related-disease
#17
Tomoe Yoshikawa, Tomohiro Watanabe, Kosuke Minaga, Ken Kamata, Masatoshi Kudo
IgG4-related disease (IgG4-RD) is a newly defined multi-organ disease proposed by Japanese physicians. IgG4-RD is characterized by elevated serum levels of IgG4 and massive infiltration of IgG4-expressing plasma cells in the affected organs. Recent studies have shown that abnormal adaptive immune responses mediated by T helper type 2 cells, regulatory T cells, follicular helper T cells, cytotoxic CD4+ T cells, and plasmablasts are involved in IgG4-RD immunopathogenesis. In addition to adaptive immune responses, innate immune responses play pathogenic roles in IgG4-RD...
October 18, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/30136608/hla-dqb1-dpb1-alleles-in-japanese-patients-with-adult-onset-still-s-disease
#18
Yuya Fujita, Hiroshi Furukawa, Tomoyuki Asano, Shuzo Sato, Makiko Yashiro Furuya, Hiroko Kobayashi, Hiroshi Watanabe, Eiji Suzuki, Tomohiro Koga, Toshimasa Shimizu, Yukitaka Ueki, Katsumi Eguchi, Naoyuki Tsuchiya, Atsushi Kawakami, Kiyoshi Migita
OBJECTIVE: HLA class II alleles are major determinants of genetic predisposition to rheumatic diseases. Predisposing effects of HLA had been suggested in AOSD, however, ethnic differences may account for variations in AOSD association with HLA. We determined the contribution of HLA-DQB1, DPB1 alleles to susceptibility to Adult-onset Still's disease (AOSD) in the Japanese population. METHODS: HLA-DQB1 and DPB1 alleles were analyzed in 87 Japanese patients with AOSD and 413 Japanese healthy subjects...
October 18, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/30299202/long-term-safety-and-efficacy-of-weekly-subcutaneous-tocilizumab-monotherapy-in-patients-with-rheumatoid-arthritis-who-had-an-inadequate-response-to-subcutaneous-tocilizumab-every-other-week-results-from-the-open-label-extension-of-the-shinobi-study
#19
Atsushi Ogata, Yoshiya Tanaka, Tomonori Ishii, Motohide Kaneko, Hiroko Miwa, Shino Ohsawa, Reiji Yamakawa
OBJECTIVE: To evaluate the long-term safety and efficacy of subcutaneous tocilizumab (TCZ-SC) monotherapy administered weekly (qw) in patients with rheumatoid arthritis who had an inadequate response to TCZ-SC every other week (q2w). METHODS: Patients who completed 12 weeks of double-blind treatment with either TCZ-SC q2w monotherapy or TCZ-SC qw monotherapy were switched to or continued to receive open-label treatment with TCZ-SC qw monotherapy for 40 weeks. Safety and efficacy were assessed...
October 9, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/30289287/a-randomized-double-blind-parallel-group-phase-iii-study-to-compare-the-efficacy-and-safety-of-ni-071-and-infliximab-reference-product-in-japanese-patients-with-active-rheumatoid-arthritis-refractory-to-methotrexate
#20
Hiroaki Matsuno, Tsukasa Matsubara
OBJECTIVES: This study aimed to demonstrate the equivalence of NI-071, an infliximab biosimilar (BS), and the infliximab reference product (RP) for treating Japanese patients with active rheumatoid arthritis (RA) refractory to methotrexate. METHODS: In this multicenter two-period phase III study, patients were treated with BS or RP for 30 weeks (Period I) in a randomized double-blind manner and then with BS for the following 24 weeks (Period II). The efficacy and safety of BS and RP were compared...
October 5, 2018: Modern Rheumatology
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