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Neurological Sciences

Zhang Ping, Wu Xiaomu, Xie Xufang, Shao Liang
BACKGROUND: The pathogenesis of Parkinson's disease (PD) is complex; it includes mitochondrial dysfunction, oxidative stress, and neuroinflammation. Notably, Toll-like receptors (TLRs) may activate inflammatory or anti-inflammatory responses in Parkinson's disease. Vinpocetine has been tested as an anti-inflammatory in both animal and in vitro research. Thus, it is important to test whether the anti-inflammatory properties of vinpocetine may have a protective effect in PD patients. METHODS: Eighty-nine Parkinson's disease patients and 42 healthy controls were recruited for this study...
October 12, 2018: Neurological Sciences
Alina Buture, Fayyaz Ahmed, Lisa Dikomitis, Jason W Boland
INTRODUCTION: Patients with cluster headache (CH), the most common trigeminal autonomic cephalalgia, often face delayed diagnosis, misdiagnosis and mismanagement. OBJECTIVES: To identify, appraise and synthesise clinical studies on the delays in diagnosis and misdiagnosis of CH in order to determine its causes and help the management of this condition. METHODS: The systematic review was prepared, conducted and reported in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis...
October 10, 2018: Neurological Sciences
Halil Onder
No abstract text is available yet for this article.
October 9, 2018: Neurological Sciences
Andrea Tacchino, Giampaolo Brichetto, Paola Zaratin, Mario Alberto Battaglia, Michela Ponzio
INTRODUCTION: Several multiple sclerosis studies matching self- and physician assessment of disease course and disability show moderate and high agreement respectively. However, the role played by socio-demographic, clinical, and quality of life (QoL) factors was not much investigated. The study aims at exploring how self-/physician agreement could depend on these variables. MATERIALS AND METHODS: Participants were asked to report own disease course and disability according to preset categories...
October 5, 2018: Neurological Sciences
Grazia Crescimanno, Marcello Romano, Rossella Spataro, Vincenzo La Bella, Oreste Marrone
No abstract text is available yet for this article.
October 4, 2018: Neurological Sciences
Xiaojuan Han, Zaiying Pang, Zhou Wang, Shangchen Xu, Youting Lin
No abstract text is available yet for this article.
October 4, 2018: Neurological Sciences
Maryam Ramezani, Yones Lotfi, Abdollah Moossavi, Enayatollah Bakhshi
Auditory brainstem response (ABR) provides useful information about the auditory brainstem pathway. However, there is little known about the subcortical speech processing in individuals with autism spectrum disorder (ASD). The aim of the present study was to investigate the subcortical speech processing in children with high functioning ASD. Twenty-eight children with ASD, with a mean age of 14.36 ± 1.86, and 28 typically developing (TD) children, with a mean age of 14.99 ± 1.92, were selected from Rofeydeh Rehabilitation Hospital (Tehran, Iran), and speech ABR (sABR) with a 40 ms synthetic /da/ syllable stimulus was recorded...
October 4, 2018: Neurological Sciences
Anna Rosliakova, Inessa Zakroyshchikova, Ilya Bakulin, Rodion Konovalov, Elena Kremneva, Marina Krotenkova, Natalya Suponeva, Mariya Zakharova
The fourteen cases of Hirayama disease (HD) are presented in this article. HD is seldom disease characterized by juvenile muscular atrophy of upper extremities and benign course. All cases were diagnosed in the Research Center of Neurology (Moscow, Russia) during the year 2015-2017. Such methods as MRI (magnetic resonance imaging), EMG (electromyography), and NCS (nerve conduction studies) have been used to confirm diagnosis of HD. Transcranial magnetic stimulation was used to exclude upper motor neuron involvement in two cases...
October 3, 2018: Neurological Sciences
Tülin Aktürk, Nermin Tanık, Halil İbrahim Serin, Hikmet Saçmacı, Levent Ertuğrul İnan
OBJECTIVE: Osmophobia and headache triggered by odors are commonly seen in migraine, and these are symptoms that differentiate migraine from other primary headaches. Since these odor-related symptoms are disease-specific, we aimed to measure the volume of olfactory bulb and depth of olfactory sulcus in migraine patients. PATIENTS AND METHOD: A total of 93 subjects, consisting of 62 episodic migraine (32 with osmophobia, 30 without osmophobia) patients and 31 healthy controls, were included in this study...
October 2, 2018: Neurological Sciences
Marzia Buonfiglio, Giuliano Avanzini, Filippo Brighina, Francesco Di Sabato
No abstract text is available yet for this article.
October 2, 2018: Neurological Sciences
Alberto Raggi
The recent manuscript by Xinglong Yang and colleagues provided the first relatively reliable estimate of restless leg syndrome (RLS) prevalence among migraine sufferers, which was estimated at 19% (95% CI 14-24%). The implications of the association between the two conditions are wide, and call for further action aimed to address common disease mechanism-associated conditions such as sleep-related ones and associated burden.
October 2, 2018: Neurological Sciences
Daniela Smirni, Pietro Smirni, Giovanni Di Martino, Maria Lorena Fontana, Lisa Cipolotti, Massimiliano Oliveri, Patrizia Turriziani
In several neurological conditions, in elderly and cognitively impaired subjects, memory functioning must be evaluated to early detect the cognitive deterioration processes. In particular, recognition memory assessment is an essential step in the clinical and neuropsychological evaluation of early memory impairments. The Recognition Memory Test (RMT) developed by Smirni et al. (G Ital Psicol XXXVII(1):325-343, 2010) is an effective instrument to assess verbal and nonverbal recognition memory in the Italian population...
October 1, 2018: Neurological Sciences
Giovanni Defazio, Alberto Albanese, Roberta Pellicciari, Cesa L Scaglione, Marcello Esposito, Francesca Morgante, Giovanni Abbruzzese, Anna R Bentivoglio, Francesco Bono, Mario Coletti Moja, Giovanni Fabbrini, Paolo Girlanda, Leonardo Lopiano, Claudio Pacchetti, Marcello Romano, Laura Fadda, Alfredo Berardelli
BACKGROUND: Diagnosis of focal dystonia is based on clinical grounds and is therefore open to bias. To date, diagnostic guidelines have been only proposed for blepharospasm and laryngeal dystonia. To provide practical guidance for clinicians with less expertise in dystonia, a group of Italian Movement Disorder experts formulated clinical diagnostic recommendations for cervical, oromandibular, and limb dystonia. METHODS: A panel of four neurologists generated a list of clinical items related to the motor phenomenology of the examined focal dystonias and a list of clinical features characterizing neurological/non-neurological conditions mimicking dystonia...
September 29, 2018: Neurological Sciences
Ramandeep Kaur, Sidharth Mehan, Shamsher Singh
Parkinson's disease (PD) is the second most common multifactorial neurodegenerative disorder affecting 3% of population during elder age. The loss of substantia nigra, pars compacta (SNpc) neurons and deficiency of striatal dopaminergic neurons produces stables motor deficient. Further, increase alpha-synuclein accumulation, mitochondrial dysfunction, oxidative stress, excitotoxicity, and neuroinflammation plays a crucial role in the pathogenesis of PD. Alpha-synuclein protein encodes for SNCA gene and disturbs the normal physiological neuronal signaling via altering mitochondrial homeostasis...
September 29, 2018: Neurological Sciences
Vandana Rai, Pradeep Kumar
BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism was reported as risk factor for multiple diseases due to its role in conversion of homocysteine to methionine. The aim of the present meta-analysis was to find out the validity of association of C677T polymorphism with epilepsy susceptibility. METHODS: Pubmed, Science Direct, Springer Link and Google Scholar, databases were searched for relevant studies up to January, 31, 2018. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were performed using five genetic models...
September 28, 2018: Neurological Sciences
Elisa Baldin, Trond Riise, Katia Mattarozzi, Alberto Gajofatto, Franco Granella, Maurizio Leone, Alessandra Lugaresi, Susanna Malagù, Luisa Motti, Walter Neri, Ilaria Pesci, Mario Santangelo, Cinzia Scandellari, Maria Rosaria Tola, Luca Vignatelli, Corrado Zenesini, Roberto D'Alessandro
BACKGROUND AND OBJECTIVES: A few studies have found that low scores on self-rated health and quality of life measures are associated with following worsening disability in multiple sclerosis (MS). We wanted to estimate the association between self-rated quality of life scores among patients with clinically isolated syndrome (CIS) and the risk of subsequent conversion to definite MS. METHODS: One hundred sixty-two patients from the GERONIMUS cohort with a symptom or sign suggestive of MS and without a definite diagnosis of MS at the time of inclusion were asked to evaluate their health-related quality of life according to MSQoL-54 scale...
September 25, 2018: Neurological Sciences
Enrica Olivola, Livia Brusa, Camilla Rocchi, Orazio Schillaci, Claudio Liguori, Rocco Cerroni, Mariangela Pierantozzi, Agostino Chiaravalloti, Alessandro Stefani, Fabrizio Stocchi
BACKGROUND: Despite its negative impact on quality of life, fatigue in Parkinson's disease (PD) remains an under-recognized issue and the underlying pathology is undetermined. OBJECTIVE: To contribute at understanding the pathogenesis of fatigue in a naturalistic cohort of cognitively intact PD patients. METHODS: In a Caucasian population of PD patients (n = 27), we evaluated to what extent fatigue (quantified as PFS-16 score) is associated with PD duration and with autonomic dysfunction, studied by both MIBG scintigraphy and autonomic nervous system testing...
September 25, 2018: Neurological Sciences
Bansidhar Tarai, Poonam Das
BACKGROUND: Acute meningitis and encephalitis (AME) is a syndrome of central nervous system (CNS) infections, which could lead to neurological damage and fatality. This study evaluates the multiplex FilmArray® ME Panel which is aimed to diagnose agents causing suspect CNS infections in north India. METHODS: A total number of 969 cerebrospinal fluid (CSF) samples collected between August 2016 and January 2018 from patients who showed clinical symptoms of CNS infections were analyzed using the FilmArray® ME Panel...
September 25, 2018: Neurological Sciences
Ludivine Vitet, Christine Patte-Mensah, Naoual Boujedaini, Ayikoé-Guy Mensah-Nyagan, Laurence Meyer
Chemotherapeutic drugs induce various side effects including painful peripheral neuropathy that represents a major concern. The widely used anticancer drug paclitaxel causes neurological side effects such as burning pain, allodynia, and hyperalgesia. Neuroprotective substances that may effectively counteract paclitaxel-induced neuropathic symptoms are needed. Here, we investigated the potential of Gelsemium sempervirens (GS) to counteract paclitaxel-evoked painful neuropathy in rats. Using the von Frey hair and acetone behavioral tests, we investigated the potential of GS centesimal (C) dilutions 3, 5, and 9C to prevent or to correct paclitaxel-induced cold allodynia and mechanical allodynia/hyperalgesia involved in neuropathic pain...
September 24, 2018: Neurological Sciences
Ghorban Taghizadeh, Pablo Martinez-Martin, Seyed-Mohammad Fereshtehnejad, Seyed Amirhasan Habibi, Negar Nikbakht, Naeeme Haji Alizadeh, Sheyda Salehi, Maryam Mehdizadeh
BACKGROUND: Having an appropriate tool for assessment of the balance status during the drug off-phase in idiopathic Parkinson's disease (PD) is relevant for clinical and research settings. Our objective was to assess the clinimetric properties of the Berg balance scale (BBS) during drug off-phase in PD. METHOD: Balance of 98 PD patients (mean age ± SD, 59.19 ± 10.88 years) was evaluated with the BBS. Other assessments in the study included the Fall Efficacy Scale-International (FES-I), Functional Reach Test (FRT), Section II of the Unified Parkinson's Disease Rating Scale-3...
September 22, 2018: Neurological Sciences
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