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Neurological Sciences

Marta Caniglia-Tenaglia, Susanna Guttmann, Chiara Monaldini, Dario Manzaroli, Mirco Volpini, Maurizio Stumpo, Elisabetta Groppo, Ilaria Casetta, Vittorio Govoni, Mattia Fonderico, Maura Pugliatti, Enrico Granieri
Epidemiological studies on multiple sclerosis (MS) carried out in Southern Europe in the last years have shown a significant increase in the disease frequency. Previous surveys conducted in the Republic of San Marino, Northern Italian peninsula, identified that the population is at high risk for MS, with a prevalence of 51.6 per 100,000 population in 1982 and of 166.7 in 2005 and with a mean annual incidence of 7.9 per 100,000 for the period 1990-2005. The present work is a community-based intensive prevalence and incidence survey, by a complete enumeration approach, to update the prevalence and incidence of MS in the Republic of San Marino...
April 18, 2018: Neurological Sciences
Simone Goebel, Elisabeth Steinmann, Bernd Leplow, H Maximilian Mehdorn
Aim of the study was the cross-cultural adaptation and validation of the German version of the Scale for Outcomes in Parkinson's disease-Sleep Scale (SCOPA-Sleep) for assessment of night-time sleep problems (NS) and daytime sleepiness (DS). Eighty-three patients with Parkinson's disease completed the SCOPA-Sleep and a multitude of measures for assessment of validity (e.g., PSQI, ESS). Twenty patients completed the SCOPA-Sleep twice within 2 months for assessment of retest reliability. Sixty-four healthy controls were also included for validity estimation...
April 14, 2018: Neurological Sciences
Silvia Colnaghi, Paolo Colagiorgio, Stefano Ramat, Maurizio Versino
No abstract text is available yet for this article.
April 13, 2018: Neurological Sciences
Reza Fekrazad, Ahmadreza Sardarian, Kamran Azma, Masoumeh Karami, Afshin Borhani-Haghighi, Behrouz Gharesi-Fard, Bahram Movahedi
Calcitonin gene related peptide (CGRP) is a mediator of neurogenic inflammation playing a major role in the pathogenesis of migraine. Increases in serum CGRP have been detected previously in migraineurs and a return to baseline values regarded as successful treatment. As gingival crevicular fluid is known to originate from the serum, the aim of this study is to measure the CGRP content of gingival crevicular fluid (GCF) in chronic migraine patients and to determine whether there is a correlation between serum and GCF values of CGRP...
April 13, 2018: Neurological Sciences
Juanjuan Ji, Yunwei Yang, Yan Lin, Xudong Li, Xiaoguang Wu, Xi Yang, Ling Zhong, Ying Tang, Zhiyong Huang, Xiaoguang He
Obstructive sleep apnea syndrome (OSAS) is a common health problem that is associated with abnormality in craniofacial morphology. The growth hormone receptor (GHR) belongs to the cytokine receptor superfamily and mediates the majority of growth hormone signaling, which, among other functions, determines mandibular growth and development. The aim of this study was to determine if correlations exist between single nucleotide polymorphisms (SNPs) in the GHR gene and OSAS in the Han or Hani ethnic groups in China...
April 13, 2018: Neurological Sciences
Gemma Lombardi, Cristina Polito, Valentina Berti, Camilla Ferrari, Giulia Lucidi, Silvia Bagnoli, Irene Piaceri, Benedetta Nacmias, Alberto Pupi, Sandro Sorbi
An early differentiation between Alzheimer's Disease (AD) and other dementias is crucial for an adequate patients' management, albeit it may result difficult for the occurrence of "atypical presentations." Current diagnostic criteria recognize the importance of biomarkers for AD diagnosis, but still an optimal diagnostic work-up isn't available. Evaluate the utility and reproducibility of biomarkers and propose an "optimal" diagnostic work-up in atypical dementia: (1) a retrospective selection of "atypical dementia cases"; (2) a repetition of diagnostic assessment by two neurologists following two different diagnostic work-ups, each consisting of multiple steps; (3) a comparison between diagnostic accuracy and confidence reached at each step by both neurologists and evaluation of the inter-rater agreement...
April 13, 2018: Neurological Sciences
Antonio Tagarelli, Anna Piro
European people believed that epilepsy was both a sacred and demoniac disease in the pre- and post-Hippocratic Age, and this belief continued into the Christian era. Epilepsy was wrapped in mystery. The present work shows an epileptic treatment using elk (Alces alces) hoof, which was better known among Northern European people, and explains its historical and popular origins that lead to its importance and success within the Official Medicine in the sixteenth and seventeenth centuries until its gradual decline as a specific treatment in the subsequent centuries...
April 12, 2018: Neurological Sciences
Chengya Dong, Zhengrong Yuan, Qi Li, Yajie Wang
This study aimed to investigate the impact of TP53 alteration on survival and clinicopathological features of glioma patients with H3K27M mutations. An individual-participant-data (IPD) meta-analysis was performed to investigate the impact of TP53 alteration on survival and clinicopathological features of patients with H3K27M mutations. Three hundred thirty-one individual records from 12 eligible glioma studies involving the H3K27M mutation were finally included in our meta-analysis, and a pooled hazard ratio (HR) of 1...
April 12, 2018: Neurological Sciences
Simona De Salvo, Lilla Bonanno, Roberto Giorgianni, Nunzio Muscarà, Francesco Freni, Fabrizia Caminiti, Demetrio Milardi, Placido Bramanti, Silvia Marino
Charcot-Marie-Tooth (CMT) disease is a genetically heterogeneous group of disorders. Pain is a less common symptom complained by CMT patients. We described a case of a 39-year-old male patient affect by Charcot-Marie-Tooth (CMT) disease compared to five healthy controls (HC), to assess the sensory and the nociceptive pathways by using LEPs recording associated to fMRI examination, to find an "objective" marker which could be used in the management of CMT patient. The nociceptive system was evaluated by laser-evoked potentials (LEPs)...
April 11, 2018: Neurological Sciences
Claudia Stancanelli, Anna Mazzeo, Luca Gentile, Giuseppe Vita
No abstract text is available yet for this article.
April 10, 2018: Neurological Sciences
Cailei Zhao, Qian Chen, Chunde Li, Jian Yang, Cong Li, Yangyang Zhou, Jianxiang Liao
To explore the relationship between NF2 promoter gene mutation and the risk of medulloblastomas (MBs). We collected tissues from 16 MB patients and 7 age-matched non-MB controls. Gene sequencing, qPCR (real-time quantitative polymerase chain reaction), IHC (immunohistochemistry), and WB (Western blot) were used to analyze the changes in the NF2 gene sequence and expression between patients and controls. We found that NF2 promoter gene mutations occurred in MB patients. The NF2 mRNA expression was higher in the controls than in patients (p = 0...
April 10, 2018: Neurological Sciences
Carlo Piccinni, Giulia Ronconi, Silvia Calabria, Letizia Dondi, Emanuele Forcesi, Elisa Rossi, Antonella Pedrini, Nello Martini
Epidemiological data on primary progressive multiple sclerosis (PPMS) are scarce. This study was aimed to evaluate the burden of PPMS in Italy with healthcare resources utilisation and costs for Italian National Health System (INHS). A 2-year cross-sectional analysis of real-world data collected in the ARCO database, covering > 10 million Italian inhabitants, was performed. From a cohort of patients affected by MS in 2014, those supposedly affected by PPMS were defined by the concurrent matching of absence of disease-modifying treatments and use of rehabilitation services...
April 10, 2018: Neurological Sciences
Jing-Peng Liu, Zhen-Nan Ye, Sheng-Yin Lv, Zong Zhuang, Xiang-Sheng Zhang, Xin Zhang, Wei Wu, Lei Mao, Yue Lu, Ling-Yun Wu, Jie-Mei Fan, Wen-Ju Tian, Chun-Hua Hang
Platelet-derived growth factor β (PDGFβ) has been proposed to contribute to the development of cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH), and soluble PDGFRβ (sPDGFRβ) is considered to be an inhibitor of PDGF signaling. We aimed at determining the sPDGFRβ concentrations in the cerebrospinal fluid (CSF) of patients with aneurysmal SAH (aSAH) and analyzing the relationship between sPDGFRβ level and CVS. CSF was sampled from 32 patients who suffered aSAH and five normal controls. Enzyme-linked immunosorbent assay was performed to determine the sPDGFRβ concentrations in the CSF...
April 10, 2018: Neurological Sciences
Walaa A Keshk, Doaa H Zineldeen, Yasser A El-Heneedy, Azza A Ghali
Acute ischemic stroke (AIS) is followed by a strong inflammatory response contributing to brain damage and making early diagnosis and treatment inevitable. Hence, obesity is a state of chronic inflammation with amplified oxidative stress; this study aimed to assess the role played by thrombomodulin (TM)/alarmin signaling pathway and copeptin in AIS initiation and severity in addition to the implication of abnormal body weight. The study was conducted on 50 participants; 30 were patients with AIS (15 overweight/obese and 15 normal weight), 10 were overweight/obese, and 10 were normal weight...
April 10, 2018: Neurological Sciences
Majid Dadmehr, Farshad Amini-Behbahani, Behzad Eftekhar, Bagher Minaei, Mohsen Bahrami
There are studies that show that the concepts of epilepsy have been rooted in Persian medicine; Avicenna "Ibn-e-Sina"-one of the great Persian physicians in the Islamic golden age (9th-12th century AD)-has considered some types of epilepsy with the association of the stomach, the spleen, the "Maraqq," and the whole body which has not been reviewed properly. These organs influence on the brain and can cause epilepsy. This article presents concept of Maraqq-related epilepsy; according to Avicenna's view, "Maraqq" is a membranous structure which is located in the abdomen (equivalent of parietal peritoneum in current nomenclature)...
April 9, 2018: Neurological Sciences
Jan Dobrovolny, Martin Smrcka, Julie Bienertova-Vasku
Traumatic brain injury is one of the most common causes for intervention in neurosurgery. Apart from its acute consequence, it can represent a further burden on individuals as well as society by being associated with significant comorbidity-mainly early-onset dementia. Oxidative stress is one of the crucial mechanisms conferring the damage to nervous tissue, and it is believed it could be, to some extent, influenced by dietary composition, largely by antioxidants contained in the diet. Under stressful conditions, cell-derived reactive oxygen species in the brain can induce the formation of lipid peroxides and the shifting of redox homeostasis...
April 7, 2018: Neurological Sciences
Michela Sforza, Francesca Assogna, Domiziana Rinaldi, Giuliano Sette, Stefania Tagliente, Francesco E Pontieri
Orthostatic hypotension is a frequent non-motor symptom of Parkinson's disease, with negative prognostic role on cognitive functions. Here we measured the acute effects of orthostatic hypotension on executive functions in Parkinson's disease patients devoid of hypertension, carotid artery stenosis, and significant chronic cerebrovascular pathology. Measurements were carried out during regular visits in outpatient setting. Twenty-eight Parkinson's disease patients were recruited and studied along scheduled outpatient visits...
April 7, 2018: Neurological Sciences
Yanbin Wang, Yao Liu, Yu Wang, Yuchen Li, Pei Wu, Huaizhang Shi
Here, we report a case of a 64-year-old female with acute-onset vertigo, nausea, and vomiting. In an emergency imaging examination, the results of computed tomography (CT) and diffusion weighted imaging (DWI) were negative. However, on 1 day post-hospital admission, a small acute infarct in the posterolateral aspect of the left medulla was detected by DWI. Extra attention should be payed to the false-negative imaging results to avoid diagnosis and treatment delay.
April 7, 2018: Neurological Sciences
Ilaria Cova, N Travi, L Maggiore, V Cucumo, C Mariani, S Pomati
Dementia is one of the main causes of disability later in life. Interventions in support of patients with dementia aim at granting the highest level of independence in activities of daily living and at delivering the required facilities; formal and informal caregivers represent the interface between patients and health services. The aims of our study were to assess caregivers' perceived needs and to relate them to their own socio-cultural features and to patients' clinical characteristics. During three consecutive months, 50 caregivers of patients with dementia were interviewed about their needs in the assistance of subjects with dementia by means of three structured questionnaires (Caregiver Needs Assessment [CNA], Zarit Burden Inventory [ZBI], Neuropsychiatric Inventory-Questionnaire [NPI-Q]) and of two open-ended questions...
April 5, 2018: Neurological Sciences
Anil Korkmaz, Omer Karti, Dilek Top Karti, Bora Yüksel, Mehmet Ozgur Zengin, Tuncay Kusbeci
We present an interesting case with nonarteritic anterior ischemic optic neuropathy (NAION) accompanied by Buerger's disease. A 43-year-old man was referred to our neuro-ophthalmology clinic with a complaint of visual deterioration in the left eye that started 5 days ago. He suffered from Buerger's disease, and he had acute pain in the right lower limb below the knee. His best corrected visual acuity was 10/10 in the right eye and 2/10 in the left eye by Snellen chart. There was a relative afferent pupil defect in the left eye...
April 5, 2018: Neurological Sciences
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