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Neurological Sciences

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https://www.readbyqxmd.com/read/28819896/highlights-of-the-issue-9-2017
#1
(no author information available yet)
No abstract text is available yet for this article.
August 17, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28815321/fixational-eye-movements-in-tourette-syndrome
#2
Aasef G Shaikh, Shlomit Ritz Finkelstein, Ronald Schuchard, Glen Ross, Jorge L Juncos
Studies of saccadic eye movements in subjects with Tourette syndrome (TS) have provided additional evidence that there is a link between TS symptoms and deficits in fronto-striato-thalamic networks. These studies revealed impaired timing and inhibition of saccades. We compared fixational eye movements, such as microsaccades and ocular drifts, in subjects with TS and healthy controls.We measured horizontal and vertical eye positions with video-oculography in 14 subjects with Tourette syndrome. We found reduced microsaccade amplitude but increased time between adjacent microsaccades (intersaccadic interval)...
August 16, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28815313/epidemiology-and-cerebrovascular-events-related-to-cervical-and-intracranial-arteries-dissection-the-experience-of-the-city-of-pisa
#3
N Giannini, L Ulivi, M Maccarrone, V Montano, G Orlandi, E Ferrari, C Cravcenco, U Bonuccelli, M Mancuso
Spontaneous dissection of cervical arteries (sCAD) is a major cause of ischemic stroke in young patients, with an incidence varying from 1.7 to 3/100,000/year for extracranial internal carotid artery (ICAD) and 1 to 1.9/100,000/year for extracranial vertebral artery (VAD). Reliable epidemiological data on stroke incidence related to sCAD are scarce in Italy. This study aims to evaluate the incidence, clinical features, and outcome of cerebrovascular events related to sCAD and spontaneous intracranial arteries dissections (sIAD) in the city of Pisa (Italy)...
August 16, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28808876/changes-of-cerebrospinal-fluid-a%C3%AE-42-t-tau-and-p-tau-in-parkinson-s-disease-patients-with-cognitive-impairment-relative-to-those-with-normal-cognition-a-meta-analysis
#4
Xiaohui Hu, Yan Yang, Daokai Gong
The cerebrospinal fluid (CSF) signature of reduced amyloid beta 1-42 (Aβ42), elevated total tau (t-tau), and phosphorylated tau181 (p-tau) is important for the early diagnosis of Alzheimer's disease (AD). Aβ42, t-tau, and p-tau have been reported in numerous studies to contribute to predicting cognitive impairment in Parkinson's disease (PDCI). However, no consistent conclusion can be drawn so far. Literatures regarding Aβ42, t-tau, and p-tau in CSF were systematically reviewed, and a meta-analysis was thus performed to evaluate the changes of these biomarkers in PDCI patients, including PD with mild cognitive impairment (PDMCI) and PD dementia (PDD) patients, relative to PD with normal cognition (PDNC) patients...
August 14, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28808795/cerebral-venous-thrombosis-continental-disparities
#5
Laith Maali, Sheema Khan, Fares Qeadan, Mahmoud Ismail, Davana Ramaswamy, Vishnumurthy S Hedna
Cerebral venous thrombosis (CVT) usually accounts for < 1% of all strokes. Global disparity and diversity in their demographics, etiology, clinical features, radiological presentation, and mortality have not been previously explored. A systematic search was performed for publications in PubMed using key words "cerebral venous thrombosis," "Cerebral vein thrombosis," and "Cortical vein Thrombosis." A total of 600 relevant studies were abstracted with strict selection criteria, and a total of 7048 patient's data were used for the final analysis...
August 14, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28808794/thiol-disulfide-homeostasis-as-a-novel-indicator-of-oxidative-stress-in-children-with-simple-febrile-seizures
#6
Bahri Elmas, Özcan Erel, Dilek Ersavaş, Yusuf Yürümez
Simple febrile seizures are generally benign, but during the seizure, elevated levels of glutamate and high levels of oxygen use due to the high metabolic brain activity result in oxidative stress. However, the relationship between febrile seizures and oxidative stress remains unclear. In this study, we investigated thiol/disulfide homeostasis as a new oxidative stress parameter in patients with simple febrile seizures. This study was performed between February 2016 and May 2016 at the Pediatric Emergency Unit...
August 14, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28799006/multiple-sclerosis-and-environmental-risk-factors-a-case-control-study-in-iran
#7
Maryam Abbasi, Seyed Massood Nabavi, Seyed Mohammad Fereshtehnejad, Nikan Zerafat Jou, Iman Ansari, Vahid Shayegannejad, Seyed Ehsan Mohammadianinejad, Mahdi Farhoudi, Abbas Noorian, Nazanin Razazian, Mahmoud Abedini, Fardin Faraji
Studies have shown an increase in the incidence of MS in Iran. The aim of our study was to evaluate the relationship between environmental exposure and MS in Iran. This case-control study was conducted on 660 MS patients and 421 controls. Many environmental factors are compared between the two groups. Our findings demonstrated that prematurity ([OR = 4.99 (95% CI 1.34-18.68), P = 0.017]), history of measles and mumps ([OR = 1.60 (95% CI 1.05-2.45), P = 0.029; OR = 1.85 (95% CI 1.22-2.78), P = 0...
August 10, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28791490/secretases-related-mirnas-in-alzheimer-s-disease-new-approach-for-biomarker-discovery
#8
REVIEW
Seyedeh Nazanin Hajjari, Mehdi Mehdizadeh, Saeed Sadigh-Eteghad, Dariush Shanehbandi, Shahram Teimourian, Behzad Baradaran
Amyloid-β (Aβ) as a crucial factor in pathogenesis of Alzheimer's disease (AD) is derived from amyloid precursor protein (APP) through a proteolytic process catalyzing by β- and γ-secretase-in amyloidogenesis pathway. Products of α-secretase cleavage also have protective effects against Aβ toxicity. According to existing evidences, microRNAs (miRNAs) show a unique pattern of expression in AD. Moreover, miRNAs regulatory effects on expression of secretases and their main components have been demonstrated in AD...
August 8, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28785821/metabolic-syndrome-is-associated-with-increased-risk-of-short-term-post-procedural-complications-after-carotid-artery-stenting
#9
Shuyang Dong, Zeyan Peng, Yong Tao, Yinchao Huo, Huadong Zhou
The risk factors for post-procedural events after carotid artery stenting (CAS) have not been well established. The aim of this study was to investigate the association between metabolic syndrome (MetS) and the risk of post-CAS complications. A total of 358 consecutive patients who underwent CAS were enrolled in this prospective study. Patients' demographic data, clinical characteristics, and complications after CAS within 30 days were recorded. Logistic regression analysis was performed to identify possible risk factors for post-procedural complications after CAS...
August 7, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28785820/wilson-s-disease-presenting-as-central-pontine-myelinolysis
#10
LETTER
Mahdi Safdarian, Renato P Munhoz, Mahboubeh Aghaei, Mohammad Rohani
No abstract text is available yet for this article.
August 7, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28780708/a-case-of-recurrent-stroke-due-to-late-onset-antiphospholipid-syndrome
#11
LETTER
Marianna Riolo, G Giussani, C Scaccabarozzi, A Lunghi, Andrea Salmaggi
No abstract text is available yet for this article.
August 5, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28780707/evidence-for-association-between-hepatitis-c-virus-and-parkinson-s-disease
#12
REVIEW
Abdelrahman Ibrahim Abushouk, Mostafa Wanees Ahmed El-Husseny, Mayar Magdy, Ammar Ismail, Attia Attia, Hussien Ahmed, Ravikishore Pallanti, Ahmed Negida
Parkinson's disease (PD) is a globally prevalent neurodegenerative disorder, characterized by progressive neuronal loss in the substantia nigra and formation of Lewy bodies. These pathological characteristics are clinically translated into motor symptoms, such as bradykinesia, rigidity, resting tremors, and postural instability. Emerging data from epidemiological studies suggest a possible association between PD and hepatitis C virus (HCV) infection, which affects up to 71 million individuals worldwide. Preclinical studies have shown that HCV can penetrate and replicate within the brain macrophages and microglial cells, increasing their production of pro-inflammatory cytokines that can directly cause neuronal toxicity...
August 5, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28780706/validity-reliability-and-sensitivity-to-change-of-the-myasthenia-gravis-activities-of-daily-living-profile-in-a-sample-of-italian-myasthenic-patients
#13
Alberto Raggi, Carlo Antozzi, Fulvio Baggi, Matilde Leonardi, Lorenzo Maggi, Renato Mantegazza
The purpose of this study is to report on the validity, reliability, and sensitivity of the myasthenia gravis activities of daily living profile (MG-ADL) in a sample of Italian patients. Patients with myasthenia gravis (MG) completed a protocol that included the MG-ADL, the WHO Disability Assessment Schedule (WHODAS 2.0), the Besta Neurological Institute rating scale for myasthenia gravis, and the MG-composite. Cronbach's alpha was used to test reliability, Spearman's correlation and intra-class correlation coefficient (ICC) to test short-term test-retest, Kruskal-Wallis test to assess differences in MG-ADL between patients with different disease severity, and Wilcoxon signed-rank test to assess sensitivity to change...
August 5, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28779361/neutrophil-to-lymphocyte-ratio-may-be-a-helpful-marker-to-evaluate-disease-activity-in-nmosd
#14
Jie Lin, Binbin Xue, Jia Li, Huaqing Xu, Xiaming Huang, Zhichao Yao, Xiang Li, Junhui Xia
Neutrophil to lymphocyte ratio (NLR) was introduced to assess the activity in autoimmune diseases. Neuromyelitis optica spectrum disorder (NMOSD) has been defined as a chronic inflammatory disease with a course of relapse-remission. Therefore, the relationship between NLR and NMOSD was assessed in this article. Data of NMOSD patients was extracted. NLR is calculated as the absolute count of neutrophil divided by the absolute count of lymphocytes. Correlations between NLR and characteristics of NMOSD patients were evaluated...
August 4, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28779360/caspr2-antibodies-in-a-patient-with-prostate-cancer-a-cognitive-deterioration-with-recurrent-and-paroxysmal-gait-ataxia-and-aphasia
#15
LETTER
Sandra Sousa, Rui Guerreiro, Cátia Carmona, Liliana Olim Gouveia, Fernando Pita
No abstract text is available yet for this article.
August 4, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28770366/management-of-pregnancy-related-issues-in-multiple-sclerosis-patients-the-need-for-an-interdisciplinary-approach
#16
Maria Pia Amato, Antonio Bertolotto, Roberto Brunelli, Paola Cavalla, Benedetta Goretti, Maria Giovanna Marrosu, Francesco Patti, Carlo Pozzilli, Leandro Provinciali, Nicola Rizzo, Nicola Strobelt, Gioacchino Tedeschi, Maria Trojano, Giancarlo Comi
Multiple sclerosis (MS) is a demyelinating and neurodegenerative disease of the central nervous system (CNS), most probably autoimmune in origin, usually occurring in young adults with a female/male prevalence of approximately 3:1. Women with MS in the reproductive age may face challenging issues in reconciling the desire for parenthood with their condition, owing to the possible influence both on the ongoing or planned treatment with the possible consequences on the disease course and on the potential negative effects of treatments on foetal and pregnancy outcomes...
August 2, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28766025/determinants-of-botulinum-toxin-discontinuation-in-multiple-sclerosis-a-retrospective-study
#17
Pamela Latino, Letizia Castelli, Luca Prosperini, Maria Rita Marchetti, Carlo Pozzilli, Morena Giovannelli
The purpose of the present study was to investigate the long-term persistence to treatment with botulinum toxin type A (BoNT-A) for multiple sclerosis (MS)-related spasticity and the determinants of BoNT-A discontinuation in daily clinical setting. We retrospectively collected data of patients who started BoNT-A injections and underwent regular follow-up visits. Determinants of BoNT-A discontinuation were explored in a time-to-event Cox regression analysis which included as independent variables a large set of demographic and clinical characteristics...
August 1, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28756576/atypical-leber-s-hereditary-optic-neuropathy-in-a-10-year-old-male-a-case-report
#18
LETTER
Yung Ju Yoo, Hee Kyung Yang, Jeong-Min Hwang
No abstract text is available yet for this article.
July 29, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28748276/resuming-the-obsolete-term-small-head-when-microcephaly-occurs-without-cognitive-impairment
#19
Piero Pavone, Andrea D Praticò, Martino Ruggieri, Renata Rizzo, Raffaele Falsaperla
Microcephaly is defined as a head circumference measurement of 2 or 3 standard deviations below the mean for age and sex. However, distinguishing the value of -2 or -3 standard deviations as a cutoff is relevant in the clinical practice, since the limit of -3 standard deviations is more frequently associated with cognitive impairment. The use of ultrasound scans in pregnancy has allowed the identification of subjects with a measurement of the head circumference at the limit of the cutoff for gestational age, but who do not subsequently show cognitive delay...
July 26, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28748275/head-trauma-and-parkinson-s-disease-results-from-an-italian-case-control-study
#20
Alessandra Nicoletti, Rosario Vasta, Giovanni Mostile, Giuseppe Nicoletti, Gennarina Arabia, Giovanni Iliceto, Paolo Lamberti, Roberto Marconi, Letterio Morgante, Paolo Barone, Aldo Quattrone, Mario Zappia
We evaluated the possible association between head trauma and Parkinson's disease (PD). The FRAGAMP (Fattori di Rischio Ambientali e Genetici Associati alla Malattia di Parkinson) study is a large Italian multicenter case-control study carried out to evaluate the possible role of environmental and genetic factors in PD. Cases and controls were enrolled from six movement disorders centers located in the Central-Southern Italy. A standardized questionnaire was administered to record demographic, epidemiological, and clinical data...
July 26, 2017: Neurological Sciences
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