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Neurological Sciences

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https://www.readbyqxmd.com/read/29052091/thc-cbd-oromucosal-spray-in-patients-with-multiple-sclerosis-overactive-bladder-a-pilot-prospective-study
#1
Giorgia Teresa Maniscalco, R Aponte, D Bruzzese, G Guarcello, V Manzo, M Napolitano, O Moreggia, F Chiariello, C Florio
Lower urinary tract dysfunctions (LUTDs) are commonly reported in multiple sclerosis (MS) patients and are mainly related to neurogenic overactive bladder (OAB). The aim of this observational study was to assess the effect of a tetrahydrocannabinol-cannabidiol (THC/CBD) oromucosal spray on resistant OAB by means of clinical and instrumental tools. Twenty-one MS patients were screened, and 15 cases have been evaluated. They underwent a specific clinical assessment (overactive bladder symptom score, OABSS) and a urodynamic assessment evaluating the maximal cystometric capacity (CCmax), bladder compliance (Qmax), maximum detrusor pressure (Pdet max), detrusor pressure at the first desire (Pdet first), bladder volume at the first desire (BVFD), leakage volume (LV), and post-void residual volume (PVR), before and after 4 weeks of THC/CBD administration...
October 19, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29052090/decreased-serum-prongf-concentration-in-patients-with-parkinson-s-disease
#2
Xiao-Min Xu, Mei-Xue Dong, Xia Feng, Yang Liu, Jun-Xi Pan, Shi-Yu Jia, Du Cao, You-Dong Wei
Parkinson's disease (PD), a progressive and age-related neurodegenerative condition, is a common neurodegenerative disorder. However, no validated biomarkers for PD have been identified to date. Accumulating evidence supports the role of proNGF-p75NTR-sortilin signaling in the neurodegeneration and pathogenesis of PD. The aim of our study was to investigate alterations in serum proNGF concentrations in PD patients and related anxiety. Seventy-seven consecutive PD patients and 39 healthy controls were enrolled, and clinical data were collected...
October 19, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29046994/peripheral-markers-of-autophagy-in-polyglutamine-diseases
#3
Giorgia Puorro, Angela Marsili, Francesca Sapone, Chiara Pane, Anna De Rosa, Peluso Silvio, Giuseppe De Michele, Alessandro Filla, Francesco Saccà
Polyglutamine disorders are neurodegenerative diseases that share a CAG repeat expansion in the coding region, resulting in aggregated proteins that can be only degraded through aggrephagy. We measured the expression of autophagy genes in peripheral blood mononuclear cells of 20 patients with Huntington's disease (HD), 20 with spinocerebellar ataxia type 2 (SCA2), and 20 healthy individuals. HD patients showed increased expression of MAP1LC3B (+ 43%; p = 0.048), SQSTM1 (+ 49%; p = 0.002), and WDFY3 (+ 89%; p < 0...
October 18, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29043468/cognitive-and-behavioral-disorders-in-parkinson-s-disease-an-update-i-cognitive-impairments
#4
Costanza Papagno, Luigi Trojano
Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by motor symptoms such as rigidity, rest tremor, and bradykinesia. However, a growing body of evidence demonstrated that PD encompasses several non-motor disturbances as well, such as cognitive impairment. Cognitive defects can be present since early stages of the disease but tend to dominate the clinical picture as the disease progresses. Around 40% of patients with PD present with cognitive impairments in several cognitive domains including attention, working memory and executive functions, language, visuospatial skills, and episodic memory; in later stages of the disease, cognitive defects and associated behavioral disorders concur to determine clinically relevant PD-associated dementia...
October 17, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29038947/analysis-of-hematological-parameters-in-patients-treated-with-ketogenic-diet-due-to-drug-resistant-epilepsy
#5
Engin Kose, Orkide Guzel, Nur Arslan
Benefits of the ketogenic diet (KD) in epileptic patients are well known while less is known about the nutritional risks of the diet and its potential impacts on biochemical nutritional status. In this study, we aimed to evaluate the hematological parameters of patients who have drug-resistant epilepsy and are treated with KD. Fifty-three patients with drug-resistant epilepsy (mean age 7.4 ± 4.4 years [2-18], 23 [43.4%] female) were included in the study. Demographic and laboratory data of the patients were retrospectively analyzed at baseline and Month 6 and Month 12 of the treatment...
October 16, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29038946/cognitive-and-behavioral-disorders-in-parkinson-s-disease-an-update-ii-behavioral-disorders
#6
Luigi Trojano, Costanza Papagno
Patients with Parkinson's disease (PD) can experience several behavioral symptoms, such as apathy, agitation, hypersexuality, stereotypic movements, pathological gambling, abuse of antiparkinsonian drugs, and REM sleep behavioral disorders. Psychoses and hallucinations, depression and anxiety disorders, and difficulties in recognizing and experiencing emotions also impair behavior and can cause severe psychosocial problems in patients with PD. Symptoms can be present since early stages of the disease, sometimes even before the appearance of classical motor symptoms, likely in relation to dopamine depletion in basal ganglia and/or to dysfunctions of other neurotrasmitter systems, and others can develop later, in some cases in relation to dopaminergic treatment...
October 16, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29027589/diagnosis-and-treatment-of-severe-neurosurgical-patients-with-pyogenic-ventriculitis-caused-by-gram-negative-bacteria
#7
Feng Shang, Yueqiao Xu, Ning Wang, Weitao Cheng, Wenjin Chen, Wanru Duan
The aim of the study is to explore the experiences in diagnosis and treatment of severe neurosurgical patients with pyogenic ventriculitis caused by gram-negative bacteria (G(-)). Nineteen patients with pyogenic ventriculitis were reviewed for their treatment. The bacterial testing results of cerebrospinal fluid (CSF), the clinical intervention, and the patients' prognosis were evaluated. The bacterial smears of ventricular drainage from all the cases were G(-) bacteria. Head CT and MRI scans confirmed that they were intraventricular empyema...
October 13, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29027029/3-hz-postural-tremor-in-multiple-system-atrophy-cerebellar-type-msa-c-a-static-posturography-study
#8
Xiaodi Li, Yuzhou Wang, Zhanhang Wang, Yan Xu, Wenhua Zheng
The objective of the study is to evaluate postural dysfunction of multiple system atrophy-parkinsonian type (MSA-P) and cerebellar type (MSA-C) by static posturography exam. A total of 29 MSA-P patients, 40 MSA-C patients, and 23 healthy controls (HC) were recruited and engaged in a sensory organization test (SOT). The amplitude of the postural sway was measured and transformed into energy value by Fourier analyzer. SOT scores, frequency of falls and typical 3-Hz postural tremors during the four stance tasks, and energy value in three different frequency bands were recorded and compared...
October 12, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29022143/comorbidity-of-gastrointestinal-disorders-migraine-and-tension-type-headache-a-cross-sectional-study-in-iran
#9
Fahimeh Martami, Zeinab Ghorbani, Maryam Abolhasani, Mansoureh Togha, Alipasha Meysamie, Alireza Sharifi, Soodeh Razeghi Jahromi
Migraine can be accompanied by some gastrointestinal (GI) disorders. In this study, we aimed to investigate the relationship between migraine and tension-type headache (TTH) and different lower and upper GI disorders as well as non-alcoholic fatty liver (NAFLD) and cholelithiasis. This cross-sectional study included 1574 overweight and obese participants who were referred to the Obesity Research Center of Sina Hospital, Tehran, Iran. The diagnosis of migraine and TTH was made by an expert neurologist based on the international classification of headache disorders-III β (ICHD III β)...
October 11, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29022132/an-exploratory-study-of-the-electronic-medical-record-and-outpatient-vascular-neurology-consultations
#10
Larissa Georgeon, Philip B Gorelick, Tenko Raykov, Muhammad U Farooq, Jiangyong Min, Christopher Goshgarian, Bradley Haveman-Gould, Amy Groenhout, Molly McCarthy
We carried out a quality improvement project utilizing the electronic medical record (EMR) to determine (1) the quality of vascular neurologists' recommendations for recurrent stroke prevention and (2) primary care provider (PCP) acknowledgement of the vascular neurologists' recurrent stroke prevention recommendations and their frequency of meeting the recommended metrics for risk factor control and lifestyle modification. We conducted a retrospective EMR chart review on a convenience sample of ischemic stroke patients during two epochs...
October 11, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29019004/multiple-sclerosis-spatial-cluster-in-tuscany
#11
Daiana Bezzini, Pasquale Pepe, Francesco Profili, Giuseppe Meucci, Monica Ulivelli, Sabina Bartalini, Mario A Battaglia, Paolo Francesconi
Tuscany (Central Italy) is a high-risk area for multiple sclerosis (MS) with a prevalence of 188 cases per 100,000 at 2011, and it is characterized by a heterogeneous geographic distribution of this disease. Our objective was to update prevalence at 2013 and to evaluate the presence of spatial clusters in Tuscany. The MS prevalence was evaluated on 31 December 2013 using a validated case-finding algorithm, based on administrative data. To identify spatial clusters, we calculated standardized morbidity ratios (SMRs) for each Tuscan administrative municipality...
October 10, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29018975/progressive-anterior-operculum-syndrome-due-to-frontotemporal-lobar-degeneration
#12
LETTER
Halil Onder, S Evren Erdener, Esen Saka
No abstract text is available yet for this article.
October 10, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29018971/csf-rbc-count-in-successful-first-attempt-lumbar-puncture-the-interest-of-atraumatic-needle-use
#13
Dimitri Renard, Eric Thouvenot
The objective of this study is to analyze CSF red blood cell (RBC) count from first-attempt lumbar punctures and to analyze parameters associated with first-attempt lumbar punctures and hemorrhagic lumbar puncture. This is a prospective analysis of consecutive patients who underwent lumbar puncture for any reason other than suspected acute subarachnoid hemorrhage. Analyzed parameters were the following: age, indication for lumbar puncture, aPTT ratio, PTT, platelet count, patient's position, needle type (atraumatic/standard), needle diameter, person performing lumbar puncture (medical student/resident/attending physician), number of lumbar levels punctured, necessity of needle repositioning, CSF RBC and white blood cell count, and protein level...
October 10, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28988305/rapidly-progressive-aspergillus-meningitis-successfully-treated-with-voriconazole-and-corticosteroids
#14
LETTER
Akiyuki Hiraga, Reiji Aoki, Keigo Nakamura, Satoshi Kuwabara
No abstract text is available yet for this article.
October 7, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28986705/rescue-therapy-with-alemtuzumab-in-multiple-sclerosis-post-natalizumab-puerperium-reactivation
#15
LETTER
Jessica Frau, Giancarlo Coghe, Giuseppe Fenu, Lorena Lorefice, Eleonora Cocco
No abstract text is available yet for this article.
October 7, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28986853/highlights-of-the-issue-11-2016
#16
(no author information available yet)
No abstract text is available yet for this article.
October 6, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28980134/chronic-demyelinating-neuropathy-with-anti-myelin-associated-glycoprotein-antibody-without-any-detectable-m-protein
#17
Yuki Sakamoto, Toshio Shimizu, Shinsuke Tobisawa, Eiji Isozaki
Previous case reports and studies have shown that anti-myelin-associated glycoprotein (MAG) antibody can be detected in patients with polyneuropathy without any detectable M-protein. Nevertheless, the frequency of and related factors have not yet been adequately investigated. The objectives of this study are to examine the prevalence of anti-MAG antibody in patients with demyelinating neuropathy without M-protein and to determine their clinical characteristics. From January, 2004, to September, 2016, consecutive patients with chronic demyelinating neuropathy were recruited...
October 4, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28980128/changes-in-routine-laboratory-tests-and-survival-in-amyotrophic-lateral-sclerosis
#18
Jessica Mandrioli, Edoardo Rosi, Nicola Fini, Antonio Fasano, Silvia Raggi, Anna Laura Fantuzzi, Giorgio Bedogni
The aim of this study is to evaluate the association between changes in routinely prescribed laboratory tests and tracheostomy-free survival in amyotrophic lateral sclerosis (ALS). Two hundred seventy-five ALS patients were retrospectively studied. BMI, forced vital capacity, hemoglobin, hematocrit, lymphocytes, cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, proteins, albumin, creatine-phosphokinase, iron, ferritin, transferrin, glucose, urea, uric acid, and creatinine were measured every 6 months from baseline to 24 months, death or study end, together with the probability of death or tracheostomy...
October 4, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28980076/the-assessment-of-hemineglect-syndrome-with-cancellation-tasks-a-comparison-between-the-bells-test-and-the-apples-test
#19
Benedetta Basagni, Antonio De Tanti, Alessio Damora, Laura Abbruzzese, Valentina Varalta, Gabriella Antonucci, Wai Ling Bickerton, Nicola Smania, Mauro Mancuso
Unilateral spatial neglect (USN) is a frequent consequence of acquired brain injury, especially following right hemisphere damage. Traditionally, unilateral spatial neglect is assessed with cancellation tests such as the Bells test. Recently, a new cancellation test, the Apples test, has been proposed. The present study aims at comparing the accuracy of these two tests in detecting hemispatial neglect, on a sample of 56 right hemisphere stroke patients with a diagnosis of USN. In order to evaluate the agreement between the Apples and Bells tests, Cohen's kappa and McNemar's test were used to assess differences between the two methods of evaluation...
October 4, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28980068/a-unique-methylation-pattern-co-segregates-with-neural-tube-defect-statuses-in-han-chinese-pedigrees
#20
Ruiping Zhang, Lirong Cao, Yizheng Wang, Yulian Fang, Linsheng Zhao, Weidong Li, Ou-Yan Shi, Chun-Quan Cai
Neural tube defects (NTDs) are a complex trait associated with gene-environment interactions. Folic acid deficiency and planar cell polarity gene mutations account for some NTD cases; however, the etiology of NTDs is still little understood. In this study, in three Han Chinese NTD pedigrees (two with multiple affected children), with no information on folic acid deficiency or supplement, we examined genome-wide methylation profiles of each individual in these families. We further compared methylation status among cases and normal individuals within the pedigrees...
October 4, 2017: Neurological Sciences
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