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Neurological Sciences

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https://www.readbyqxmd.com/read/29450761/an-electroglottographical-analysis-based-discriminant-function-model-differentiating-multiple-sclerosis-patients-from-healthy-controls
#1
George D Vavougios, Triantafyllos Doskas, Kostas Konstantopoulos
Dysarthrophonia is a predominant symptom in many neurological diseases, affecting the quality of life of the patients. In this study, we produced a discriminant function equation that can differentiate MS patients from healthy controls, using electroglottographic variables not analyzed in a previous study. We applied stepwise linear discriminant function analysis in order to produce a function and score derived from electroglottographic variables extracted from a previous study. The derived discriminant function's statistical significance was determined via Wilk's λ test (and the associated p value)...
February 15, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29450760/association-of-facet-tropism-and-orientation-with-lumbar-disc-herniation-in-young-patients
#2
Qiang Zhou, Donghui Teng, Tao Zhang, Xinwei Lei, Wenxue Jiang
Facet tropism and orientation are thought to be associated with lumbar disc herniation (LDH), but the relationship is not well established. Moreover, the effect of facet joint on LDH has not been outlined in young patients. The objective of this study was to investigate the associations of facet joint tropism and orientation with LDH in young patients (18-35 years) by computed tomography (CT). Fifty-three patients with LDH and 129 with neither LDH nor low back pain (18-35 years) were included in this study...
February 15, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29445989/relevance-of-sleep-quality-on-caregiver-burden-in-parkinson-s-disease
#3
Luigi Bartolomei, Andrea Pastore, Lucia Meligrana, Elena Sanson, Nicola Bonetto, Giacomo Maria Minicuci, Sandro Zambito Marsala, Tiziana Mesiano, Lorenzo Bragagnolo, Angelo Antonini
Parkinson's disease (PD) is a neurodegenerative disorder which affects the quality of life of patient and their family. Sleep disorders appear in 80-90% of PD patients and have a great impact on the PD well-being. We examined the relationship of patients' sleep quality and depression on burden, mood, quality of life, and quality of sleep of their caregivers. A multicenter, regional (Veneto), observational, cross-sectional study that included 55 patient-caregiver pairs was conducted. Patients were assessed using Parkinson's Disease Sleep Scale (PDSS) and Epworth Sleepiness Scale (ESS) for sleep disorders, Beck Depression Inventory (BDI) as a measure of depression, and Parkinson's Disease Questionnaire (PDQ-39) as a measure of quality of life...
February 14, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29441487/prior-antiplatelet-therapy-is-not-associated-with-larger-hematoma-volume-or-hematoma-growth-in-intracerebral-hemorrhage
#4
Verena van Ginneken, Patricia Engel, Jochen B Fiebach, Heinrich J Audebert, Christian H Nolte, Andrea Rocco
Hematoma volume (HV) and hematoma growth (HG) predict mortality and poor outcome in intracerebral hemorrhage (ICH). While the influence of oral anticoagulation on HV, HG and outcome is well established, the effect of prior antiplatelet therapy (APT) remains uncertain. We retrospectively examined data from all patients with acute, primary ICH, and baseline head CT admitted to our department between January 2005 and February 2014. HV were calculated by ABC/2 method. HG was defined as present if HV increased between baseline and follow-up CT ≥ 30% or ≥ 6 mL...
February 14, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29441486/dopamine-transport-system-imaging-is-pathologic-in-niemann-pick-type-c-case-report
#5
LETTER
Svetlana Tomic
No abstract text is available yet for this article.
February 13, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29441485/clinical-spectrum-of-c9orf72-expansion-in-a-cohort-of-huntington-s-disease-phenocopies
#6
Joana Martins, Joana Damásio, Alexandre Mendes, Nuno Vila-Chã, José E Alves, Cristina Ramos, Sara Cavaco, João Silva, Isabel Alonso, Marina Magalhães
The expansion in the C9orf72 gene has been recently reported as a genetic cause of Huntington's disease (HD) phenocopies. We aim to assess the frequency of the C9orf72 gene expansion in a Portuguese HD phenocopies cohort. Twenty HD phenotype-like patients without diagnosis were identified in our institutional database. C9orf72 gene expansion was detected using repeat-primed PCR. Clinical files were reviewed to characterize the phenotype of expansion-positive cases. One patient (5%) was positive for the C9orf72 expansion...
February 13, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29441484/real-life-evaluation-of-safinamide-effectiveness-in-parkinson-s-disease
#7
Francesca Mancini, Alessio Di Fonzo, Giulia Lazzeri, Linda Borellini, Vincenzo Silani, Marco Lacerenza, Cristoforo Comi
In this retrospective study, we evaluated both efficacy and effectiveness of safinamide 50 and 100 mg in the treatment of motor fluctuations and disabling dyskinesias in a cohort of patients with idiopathic Parkinson's disease (PD). Ninety-one PD patients were evaluated during the first year of commercialization of the drug, both prior to starting safinamide and at the last available follow-up. Evaluations were based on the Unified Parkinson's Disease Scale part III (UPDRS III), Hoehn & Yahr (HY), Unified Dyskinesia Rating Scale (UDysRS) walking and balance item 9 score, daily time spent in OFF and in ON with disabling dyskinesias (1 week diary), mean daily dose of levodopa (LD), dopamine-agonists (DA), catechol-O-methyl transferase inhibitor (COMT-I), monoamine oxidase B inhibitor (MAOB-I), and their LD equivalent dose (LEDD)...
February 13, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29441483/natalizumab-reduces-serum-pro-angiogenic-activity-in-ms-patients
#8
Pietro Iaffaldano, Domenico Ribatti, Maria Trojano
Angiogenesis has been implicated in the pathobiology of multiple sclerosis (MS). Osteopontin exerts a pro-angiogenetic effect and is increased in body fluid of MS patients. To evaluate the effect of 1 year natalizumab treatment on serum pro-angiogenic activity and on plasma osteopontin levels in relapsing (RR) MS patients. Ten RRMS patients scheduled for natalizumab treatment were enrolled and evaluated at baseline and after 1-year natalizumab treatment. Pro-angiogenic activity was assessed by a chick embryo chorioallantoic membrane assay (CAM), osteopontin levels were evaluated by an enzyme-linked immunosorbent assay...
February 13, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29441482/spontaneous-intracranial-hypotension-with-chronic-brain-sagging-causing-foramen-magnum-csf-circulation-disorder-reversible-after-lumbar-epidural-blood-patch
#9
LETTER
Enrico Ferrante, Valentina Prone, Fabio Rubino, Mirko Ferrante
No abstract text is available yet for this article.
February 13, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29441481/whole-exome-sequencing-reveals-a-rare-interferon-gamma-receptor-1-mutation-associated-with-myasthenia-gravis
#10
Guoyan Qi, Peng Liu, Shanshan Gu, Hongxia Yang, Huimin Dong, Yinping Xue
Our study is aimed to explore the underlying genetic basis of myasthenia gravis. We collected a Chinese pedigree with myasthenia gravis, and whole-exome sequencing was performed on the two affected siblings and their parents. The candidate pathogenic gene was identified by bioinformatics filtering, which was further verified by Sanger sequencing. The homozygous mutation c.G40A (p.V14M) in interferon gamma receptor 1was identified. Moreover, the mutation was also detected in 3 cases of 44 sporadic myasthenia gravis patients...
February 13, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29429118/latent-systemic-lupus-erythematosus-presenting-with-hypokalaemic-quadriparesis-and-central-pontine-myelinolysis
#11
LETTER
Hans Raj Pahadiya, Manoj Lakhotia, Ronak Gandhi, Payal Bargujar
No abstract text is available yet for this article.
February 10, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29429117/ct-and-mr-myelography-in-superficial-siderosis
#12
LETTER
Nicola Morelli, Eugenia Rota, Paolo Immovilli, Giuseppe Marchesi, Emanuele Michieletti, Donata Guidetti
No abstract text is available yet for this article.
February 10, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29427168/diagnostic-test-accuracy-of-the-montreal-cognitive-assessment-in-the-detection-of-post-stroke-cognitive-impairment-under-different-stages-and-cutoffs-a-systematic-review-and-meta-analysis
#13
Dan Shi, Xiao Chen, Zheng Li
The purposes of this review were to give the optimal cutoffs of the Montreal Cognitive Assessment (MoCA) by comparing sensitivity and specificity under different cutoffs and compare the MoCA with other screening tools in post-stroke cognitive impairment (PSCI) determined by a neuropsychological evaluation. Articles were derived from a systematic search in PubMed, Web of science, Embase, and CINAHL and were assessed for internal validity by the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2). The figure of risk of bias was made by Review Manager 5...
February 9, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29427167/highlights-of-the-issue-2-2018
#14
(no author information available yet)
No abstract text is available yet for this article.
February 9, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29427166/the-epidemiology-of-parkinson-s-disease-in-the-italian-region-friuli-venezia-giulia-a-population-based-study-with-administrative-data
#15
Francesca Valent, Grazia Devigili, Sara Rinaldo, Stefania Del Zotto, Annarita Tullio, Roberto Eleopra
Parkinson's disease is known to pose a relevant burden to society in industrialized countries. However, not much research has been conducted on the epidemiology of this disease in Italy. Our aim was to estimate the incidence rate and prevalence of Parkinson's disease in the Italian Friuli Venezia Giulia region using administrative health-related databases. Five regional administrative databases (hospitalizations, exemptions from medical charges, drug prescriptions, nursing homes, and home visits) were individually linked with one another through an anonymous stochastic univocal key...
February 9, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29427165/association-of-mthfr-gene-polymorphisms-with-migraine-in-north-indian-population
#16
Sukhvinder Kaur, Arif Ali, Anil Kumar Pandey, Balkirat Singh
Polymorphisms in MTHFR gene are mostly associated with increased levels of homocysteine in the absence of dietary folate and are a risk factor for complex neurovascular diseases like migraine. The aim of present case-control study was to determine the association between MTHFR gene polymorphisms (C667T; rs 1801133, A1298C; rs 1801131) with migraine susceptibility. In total, 100 patients with migraine (23with MA and 77 with MO) and age-sex matched 100 healthy controls were included in this study from OPD of ESIC Medical College & Hospital, Faridabad...
February 9, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29411156/in-memoriam-of-corrado-messina
#17
Giuseppe Vita
No abstract text is available yet for this article.
February 6, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29396813/association-between-clu-gene-rs11136000-polymorphism-and-alzheimer-s-disease-an-updated-meta-analysis
#18
Ruixia Zhu, Xu Liu, Zhiyi He
Large-scale genome-wide association studies (GWAS) identified that the single nucleotide polymorphism rs11136000 in Clusterin (CLU) gene was associated with risk of Alzheimer's disease (AD) in Caucasian ancestry. However, recent studies reported either a weak association or no association between rs11136000 polymorphism and AD in Asian populations. Therefore, we performed a meta-analysis to explore whether rs11136000 polymorphism is associated with susceptibility to AD in Asian populations. A total of 17 articles including 26 studies with 19,829 cases and 30,900 controls, which were identified by searching PubMed, MEDLINE, and AlzGene up to Nov 2016, were collected for this meta-analysis...
February 2, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29396812/replay-to-phenotypic-spectrum-of-polg1-mutations
#19
LETTER
Elena Cardaioli, Paola Da Pozzo, Antonio Federico
No abstract text is available yet for this article.
February 2, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29383618/multiple-brain-metastases-a-surgical-series-and-neurosurgical-perspective
#20
Maurizio Salvati, Maria Pia Tropeano, Vincenza Maiola, Laura Lavalle, Christian Brogna, Claudio Colonnese, Alessandro Frati, Alessandro D'Elia
Despite review papers claim for radical treatment of oligometastatic patients, only few surgical series have been published. In this study, we analyze results and actual role of surgical resection for the management of patients with multiple brain metastases. This retrospective study compares surgical results of two groups of patients consecutively treated in our Institute from January 2004 to June 2015. The first group comprises all 32 patients with multiple brain metastases with only 2-3 lesions who underwent surgical resection of all lesions; the second group comprises 30 patients with a single surgically treated brain mestastasis compatible with the first group (match-paired control series)...
January 30, 2018: Neurological Sciences
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