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Neurological Sciences

Giacomo Tondo, Fabiola De Marchi, Emanuela Terazzi, Paolo Prandi, Marta Sacchetti, Cristoforo Comi, Roberto Cantello
BACKGROUND AND AIM: Chronic obstructive pulmonary disease (COPD) may be associated with worsening of cognitive performance. We studied patients with Alzheimer's disease (AD) with and without COPD, and we analyzed, in a retrospective way, clinical and neuropsychological variables to verify if COPD plays a pejorative role on cognitive or functional autonomy in patients with dementia. METHODS: We enrolled 23 adult patients (AD-COPD) with probable AD and COPD and 23 with AD only (AD-only); they were matched for sex, age, educational level, and Mini Mental State Examination (MMSE) at the disease onset...
June 21, 2018: Neurological Sciences
Mohammad Rohani, Alfonso Fasano, Anthony E Lang, Babak Zamani, Leila Javanparast, Mohammad-Masoud Rahimi Bidgoli, Afagh Alavi
No abstract text is available yet for this article.
June 21, 2018: Neurological Sciences
Taewon Kim, Jaseong Koo, Seong-Hoon Kim, In-Uk Song, Sung-Woo Chung, Kwang-Soo Lee
Hemorrhagic transformation (HT) is one of the most feared complications of acute recanalization therapies. The aim of this study was to evaluate whether blood-brain barrier permeability (BBBP) imaging can predict HT in the setting of acute recanalization therapy and to determine the sensitivity and specificity of BBBP for the prediction of HT according to the type of reperfusion therapy. We assessed a total of 46 patients who received recanalization therapy (intravenous (IV) recombinant tissue plasminogen activator (tPA), mechanical thrombectomy with a stent retriever or both) for acute ischemic stroke within the internal carotid artery or middle cerebral artery...
June 16, 2018: Neurological Sciences
Mehmet Bugrahan Duz, Selcuk Dasdemir, Aysel Kalayci Yigin, Mehmet Ali Akalin, Mehmet Seven
Hereditary spastic paraparesis (HSP) constitutes both genetic and clinically heterogeneous group of upper motor neuron diseases. Half of the individuals with autosomal dominant (AD) HSP have mutations in SPAST, ATL1, and REEP1 genes. This study was conducted to elucidate the genetic etiology of patients with the pure type AD-HSP diagnosis. The patient group consisted of 23 individuals from 6 families in Turkey. In the first step of work, Sanger sequencing (SS) was performed in ATL1, SPAST, and REEP1 genes and the second phase whole-exome sequencing (WES) was performed following SS analysis for the patients with no detected mutations in these genes...
June 16, 2018: Neurological Sciences
Bonaventura Casanova, Laura Lacruz, María Luisa Villar, José Andrés Domínguez, María Carcelén Gadea, Francisco Gascón, Javier Mallada, David Hervás, María Simó-Castelló, José Carlos Álvarez-Cermeño, Carmen Calles, Javier Olascoaga, Lluís Ramió-Torrentà, Carmen Alcalá, Angeles Cervelló, Isabel Boscá, Francisco Carlos Pérez-Mirallles, Francisco Coret
OBJECTIVE: To study the efficacy of interferon beta (IFNβ) and glatiramer acetate (GA) related to the presence of oligoclonal M bands (OCMB) in the cerebrospinal fluid in relapsing-remitting multiple sclerosis (RRMS). METHOD: This is an observational, multicenter and retrospective study with prospectively collected data of patients that started treatment with IFNβ or GA. Treatment decision was made blinded to the OCMB status. Time to first attack after starting therapy was compared by using Kaplan-Meier curves, and adjustment by Cox regression analysis was performed...
June 7, 2018: Neurological Sciences
Jiaojie Hui, Jianping Zhang, Xuqiang Mao, Zaiwang Li, Xinxin Li, Fengyun Wang, Tao Wang, Qingfang Yuan, Sunwei Wang, Mengjia Pu, Guangjun Xi
The association between glycemic variability and early neurological deterioration (END) in acute ischemic stroke remains unclear. This study attempted to explore whether initial glycemic variability increases END in diabetic patients with acute ischemic stroke. We enrolled type 2 diabetic patients undergoing acute ischemic stroke from November 2015 to November 2016. A total of 336 patients within 72 h from stroke onset were included. The serum glucose levels were checked four times per day during the initial 3 hospital days...
June 5, 2018: Neurological Sciences
Jone Bocos-Portillo, Inés Escalza-Cortina, Marian Gómez-Beldarrain, Aida Rodriguez-Sainz, Juan Carlos Garcia-Monco
The presence of small hippocampal hyperintense lesions on diffusion-weighted (DW) MRI can respond to different etiologies and represents a challenge where clinical judgment is imperative, since therapeutic approach may be quite different.We here report three patients with similar neuroradiological findings, i.e., hyperintense punctate hippocampal lesions on diffusion-weighted MRI sequences, yet of different origin. The first one presented with isolated amnesia (transient global amnesia), the second one with amnesia and seizures, and the third one with seizures...
June 2, 2018: Neurological Sciences
Mehrdokht Mazdeh, Alireza Komaki, Mir Davood Omrani, Vajihe Gharzi, Arezou Sayad, Mohammad Taheri, Soudeh Ghafouri-Fard
Beta-secretase 1 (BACE1) gene encodes a transmembrane protease from the peptidase A1 family of aspartic proteases whose role in the pathogenesis of Alzheimer's disease has been assessed. The enzymatic activity of BACE1 on several proteins implicated in epileptogenesis implies its role in the pathogenesis of epilepsy. In the present study, we assessed expression of BACE1 and its naturally occurring antisense (BACE1-AS) in peripheral blood of 40 epileptic patients and 40 age- and sex-matched healthy subjects...
June 2, 2018: Neurological Sciences
Marwa Elhady, Eman R Youness, Heba S Gafar, Ali Abdel Aziz, Rehab S I Mostafa
Irisin and chemerin peptides expression are triggered by hypoxia and involved in activation of inflammatory cascades in various organs including the brain; however, their role in epilepsy is not fully illustrated. This study aims to explore the predictive role of irisin and chemerin for seizure control in children with idiopathic epilepsy. This cross-sectional comparative study included 50 children with idiopathic epilepsy; 25 of them had controlled seizures over the previous 6 months and 30 age- and sex-matched healthy children as controls...
June 2, 2018: Neurological Sciences
Giorgia Simonetti, Maria Rosa Terreni, Francesco DiMeco, Laura Fariselli, Paola Gaviani
No abstract text is available yet for this article.
June 1, 2018: Neurological Sciences
Maria Elena Pessa, Lorenzo Verriello, Giada Pauletto, Gian Luigi Gigli, Mariarosaria Valente
No abstract text is available yet for this article.
May 31, 2018: Neurological Sciences
Kosuke Tanioka, Mutsumi Okura, Manami Inoue, Koh-Ichiro Taniguchi, Mitsutaka Taniguchi, Toshiaki Hamano, Naoko Tachibana
OBJECTIVES: Preventing augmentation is the critical clinical issue for RLS treatment. As for augmentation in Asian RLS patients, there have been only four studies and the follow-up durations of these studies were not long. We investigated Japanese RLS patients with longer duration of treatment in a clinical setting. METHODS: This study is a retrospective assessment of 42 RLS patients with follow-up durations of longer than 18 months (78.4 ± 29.2, range 19-139) at two urban sleep centers in Osaka, Japan from May 2004 to April 2014...
May 29, 2018: Neurological Sciences
Jin-Hua Xue, Zhi-Ping Hu, Ping Lai, De-Qing Cai, Er-Sheng Wen
BACKGROUND: Parkinson's disease (PD), the second most common neurodegenerative disease, has serious clinical effects. Research on PD is increasing, but the quantity and quality of this research have not been reported. METHODS: To analyze the most-cited articles on PD and provide information about developments in this field, we searched for articles in the Web of Science for the keyword "Parkinson*" in the title. We selected the 100 most-cited articles and evaluated information including citation number, publication time, journal, impact factor, authors, original country, institution of corresponding author, and study type...
May 28, 2018: Neurological Sciences
Arman Zargaran, Afshin Borhani-Haghighi, Mohammad Salehi-Marzijarani, Pouya Faridi, Saeid Daneshamouz, Amir Azadi, Hossein Sadeghpour, Amirhossein Sakhteman, Abdolali Mohagheghzadeh
Phytotherapy is a source of finding new remedies for migraine. Traditional chamomile oil (chamomile extraction in sesame oil) is a formulation in Persian medicine (PM) for pain relief in migraine. An oleogel preparation of reformulated traditional chamomile oil was prepared and then standardized based on chamazulene (as a marker in essential oil) and apigenin via gas chromatography (GC) and high-performance liquid chromatography (HPLC) methods, respectively. A crossover double-blind clinical trial was performed with 100 patients...
May 28, 2018: Neurological Sciences
Xin Yu, Nan Zhang, Shuang Liu, Zhiyu Xi, Yuan Zhang
The aim of the current study was to clarify the role of four common genetic polymorphisms in the interleukin-1β (IL-1B) and interleukin-1α (IL-1A) genes on risk of febrile seizures (FS) by means of meta-analyses. We searched for studies published until February 2018 using ISI Web of Science, Pubmed, Wanfang, and Chinese National Knowledge Infrastructure databases. The pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using MetaAnalyst version Beta 3.13. Seventeen case-control studies were included for meta-analysis...
May 28, 2018: Neurological Sciences
Kostas Konstantopoulos, Eleni Zamba-Papanicolaou, Kyproula Christodoulou
BACKGROUND: Dysarthrophonia is often reported by hereditary spastic paraplegia (HSP) patients with SPG11 mutations but it has been poorly investigated. OBJECTIVE: The goal of this study was to investigate dysarthrophonia in SPG11 patients using quantitative measures. The voice/speech of two patients and a non-affected mutation carrier was recorded and analyzed using electroglottography (EGG) and speech acoustics. RESULTS: Dysarthrophonia showed a higher standard deviation of the average fundamental frequency, a three to eight times higher jitter, a 80-110 Hz higher mean fundamental frequency, and a two times higher fundamental frequency range...
May 26, 2018: Neurological Sciences
Ge Tan, Ruozhen Yuan, ChenChen Wei, Mangmang Xu, Ming Liu
Association between serum calcium and magnesium versus hemorrhagic transformation (HT) remains to be identified. A total of 1212 non-thrombolysis patients with serum calcium and magnesium collected within 24 h from stroke onset were enrolled. Backward stepwise multivariate logistic regression analysis was conducted to investigate association between calcium and magnesium versus HT. Calcium and magnesium were entered into logistic regression analysis in two models, separately: model 1, as continuous variable (per 1-mmol/L increase), and model 2, as four-categorized variable (being collapsed into quartiles)...
May 26, 2018: Neurological Sciences
Dong-Kyu Yeo, Jung E Park, Kyum-Yil Kwon
No abstract text is available yet for this article.
May 24, 2018: Neurological Sciences
Giovanni Fabbrini, Antonella Conte, Alfredo Berardelli
No abstract text is available yet for this article.
May 24, 2018: Neurological Sciences
Mubashir Hassan, Saba Shahzadi, Hany Alashwal, Nazar Zaki, Sung-Yum Seo, Ahmed A Moustafa
Cas scaffolding protein family member 4 and protein tyrosine kinase 2 are signaling proteins, which are involved in neuritic plaques burden, neurofibrillary tangles, and disruption of synaptic connections in Alzheimer's disease. In the current study, a computational approach was employed to explore the active binding sites of Cas scaffolding protein family member 4 and protein tyrosine kinase 2 proteins and their significant role in the activation of downstream signaling pathways. Sequential and structural analyses were performed on Cas scaffolding protein family member 4 and protein tyrosine kinase 2 to identify their core active binding sites...
May 22, 2018: Neurological Sciences
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