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Neurological Sciences

Haoyuan Yin, Ying Shao, Xuan Chen
To analyze the effects of extracellular matrix metalloproteinase inducer (CD147) on glioma proliferation, apoptosis, invasion, and angiogenesis. Tissue samples were obtained from 101 glioma cases while normal brain tissues were obtained from 30 brain injury cases. Immunohistochemical assay was performed to detect the expressions of CD147, CD34, and VEGF in tissue samples. QRT-PCR was performed to detect the relative expression of CD147 mRNA in human glioma cell lines. CD147 siRNA was transfected into glioma cell line U251...
October 19, 2016: Neurological Sciences
Chiara Concetta Incerti, Ornella Argento, Giuseppe Magistrale, Elisabetta Ferraro, Carlo Caltagirone, Valerio Pisani, Ugo Nocentini
Multiple sclerosis (MS) and working status have recently arisen great interest. Fatigue, physical disability, cognition, and psychological disturbances have been linked to unemployment, as well to accidents during daily activities. The aim of our study was to determine frequency of different types of accidents at workplace (AWE) and possible clinical differences among employed (MSe) and unemployed (MSu) MS patients. Sixty MS patients (31 employed, 29 unemployed) and twenty healthy control subjects were recruited...
October 19, 2016: Neurological Sciences
Miki Nakamura, Kazutaka Jin, Kazuhiro Kato, Hisashi Itabashi, Masaki Iwasaki, Yosuke Kakisaka, Nobukazu Nakasato
To investigate whether seizure lateralization affects sleep macrostructure in patients with left and right temporal lobe epilepsy (TLE), as rapid eye movement (REM) sleep is shorter in patients with right hemispheric cerebral infarction than with left. We retrospectively analyzed data from 16 patients with TLE (6 men and 10 women aged 34.9 ± 11.4 years) who underwent polysomnography as well as long-term video electroencephalography. Ten patients were diagnosed with left TLE and six patients with right TLE...
October 19, 2016: Neurological Sciences
Alice Laroni, Davide Brogi, Vincenzo Brescia Morra, Leonello Guidi, Carlo Pozzilli, Giancarlo Comi, Alessandra Lugaresi, Renato Turrini, Debora Raimondi, Antonio Uccelli, Giovanni Luigi Mancardi
: The safety profile of fingolimod is well established in clinical trials and post-marketing studies. This study aimed to evaluate the safety and tolerability of fingolimod in a cohort of Italian patients with relapsing-remitting multiple sclerosis (RRMS). This is a non-comparative, open-label, multicentre, interventional study conducted in patients with RRMS with no suitable alternative treatment option. Safety and tolerability of fingolimod 0.5 mg were assessed by recording adverse events (AEs) and serious AEs (SAEs)...
October 18, 2016: Neurological Sciences
Runmei Zou, Shuo Wang, Liping Zhu, Lijia Wu, Ping Lin, Fang Li, Zhenwu Xie, Xiaohong Li, Cheng Wang
To evaluate the value of Calgary score and modified Calgary score in differential diagnosis between neurally mediated syncope and epilepsy in children. 201 children experienced one or more episodes of loss of consciousness and diagnosed as neurally mediated syncope or epilepsy were enrolled. Calgary score, modified Calgary score and receiver-operating characteristic curve were used to explore the predictive value in differential diagnosis. There were significant differences in median Calgary score between syncope [-4...
October 17, 2016: Neurological Sciences
Danira Bažadona, Vladimir Miletić
No abstract text is available yet for this article.
October 15, 2016: Neurological Sciences
Akihiro Tsukahara, Hideto Nakajima, Takafumi Hosokawa, Fumiharu Kimura, Tetsushi Yoshikawa
No abstract text is available yet for this article.
October 14, 2016: Neurological Sciences
Angela Federico, Stefano Tamburin, Alice Maier, Marco Faccini, Rebecca Casari, Laura Morbioli, Fabio Lugoboni
Benzodiazepines (BZDs) are the most widely prescribed drug class in developed countries, but they have high potential for tolerance, dependence and abuse. Cognitive deficits in long-term BZD users have long been known, but previous results might have been biased by patients' old age, coexisting neurological or psychiatric conditions or concurrent alcohol or psychotropic drug dependence. The study was aimed to explore the neuropsychological effect of high-dose BZD dependence, which represents an emerging addiction phenomenon...
October 11, 2016: Neurological Sciences
Alessandra Gaiani, Sara Pompanin, Renato Zambello, Chiara Briani, Annachiara Cagnin
No abstract text is available yet for this article.
October 7, 2016: Neurological Sciences
Herbert Tejada-Meza, Pedro J Modrego
Extra-ischaemic (remote) brain heamorrhages after thrombolysis for ischaemic stroke occur in less than 3 % of treated patients, but it worsens prognosis. Little attention has been paid to the location of the haematomas. Among 12 patients with remote brain haemorrhage after thrombolysis, we report three patients with haemorrhage in the cerebellar vermis (25 %), with poor outcome. Previous hypertensive vasculopathy is deemed to be the most plausible cause.
October 5, 2016: Neurological Sciences
Maurizio Paciaroni, Leonardo Pantoni
The administration of thrombolytic therapy in elderly patients with dementia and acute ischemic stroke may be controversial, because the reported risk of rt-PA associated intracerebral hemorrhage in these patients is higher compared with that of patients without dementia and because these patients are already disabled. Moreover, there are known risk factors for hemorrhagic transformation in patients with dementia: amyloid angiopathy, leukoaraiosis and the presence of microbleeds. In this review, we describe the impact of dementia on functional outcome following thrombolytic therapy for acute ischemic stroke and discuss some of the issues related to the use of this therapy in this specific patient's population...
October 3, 2016: Neurological Sciences
Francesco Saccà, Chiara Pane, Anna De Rosa, Margherita Matarazzo, Vincenzo Brescia Morra
No abstract text is available yet for this article.
October 3, 2016: Neurological Sciences
Rita Formisano, Eva Azicnuda, Maryam Khan Sefid, Mauro Zampolini, Federico Scarponi, Renato Avesani
Establish the best time to start rehabilitation by means of scientific evidence. Observational study in patients with a diagnosis of Severe Brain Injury who received intensive inpatient rehabilitation after acute care. 1470 subjects enrolled: 651 with Traumatic Brain Injury (TBI) and 819 with Non-TBI. Male gender was prevalent in the population study, but sex distribution was not different among groups, with a prevalence of male gender in both populations. This project involved 29 rehabilitation facilities for Severe ABI...
October 1, 2016: Neurological Sciences
Atefeh Entezari, Mahmoud Shekari Khaniani, Tayyeb Bahrami, Sima Mansoori Derakhshan, Hossein Darvish
Male carriers of an expansion of CGG alleles (with 55-200 CGG repeats) in the FMR1 gene are affected with Fragile X-associated tremor/ataxia syndrome (FXTAS). On the other hand, individuals with Parkinson's disease (PD) or Parkinsonism spectrum disorders may have some clinical features that overlap with FXTAS. To investigate the possible association between PD and FMR1 expanded alleles, we screened a total of 154 male PD patients and 190 gender- and age-matched healthy control subjects from Iran. Eleven intermediate allele carriers (7...
October 1, 2016: Neurological Sciences
Milena Cerciello, Valeria Isella, Alice Proserpi, Costanza Papagno
Alzheimer's disease (AD), vascular dementia (VaD) and frontotemporal dementia (FTD) are the most common forms of dementia. It is well known that memory deficits in AD are different from those in VaD and FTD, especially with respect to cued recall. The aim of this clinical study was to compare the memory performance in 15 AD, 10 VaD and 9 FTD patients and 20 normal controls by means of a 24-item Grober-Buschke test [8]. The patients' groups were comparable in terms of severity of dementia. We considered free and total recall (free plus cued) both in immediate and delayed recall and computed an Index of Sensitivity to Cueing (ISC) [8] for immediate and delayed trials...
September 26, 2016: Neurological Sciences
Vincent Trebossen, Noomane Bouaziz, René Benadhira, Dominique Januel
No abstract text is available yet for this article.
September 26, 2016: Neurological Sciences
Francesco M Galassi, Michael E Habicht, Frank J Rühli
No abstract text is available yet for this article.
September 24, 2016: Neurological Sciences
Fioravante Capone, Gianluca Capone, Giovanni Di Pino, Lucia Florio, Gianluca Oricchio, Vincenzo Di Lazzaro
There is great interest about the individual differences that influence the ability of dealing with risky decisions. In this light, an intriguing question is whether decision-making during risk is related to other cognitive abilities, especially executive functions. To investigate, in healthy subjects, the existence of a possible correlation between risk-taking and cognitive abilities, the balloon analogue risk task (BART) has been exploited to assess risk-taking propensity and the random number generation (RNG), to investigate cognitive functions...
September 22, 2016: Neurological Sciences
Paolo Borelli, Vittorio Mantero, Angelo Aliprandi, Alessandro Lunghi, Andrea Salmaggi
No abstract text is available yet for this article.
September 22, 2016: Neurological Sciences
Antonella De Carolis, Virginia Cipollini, Nicole Donato, Micaela Sepe-Monti, Francesco Orzi, Franco Giubilei
Although a large number of studies have examined possible differences in cognitive performance between Alzheimer's disease (AD) and vascular dementia (VaD), the data in the literature are conflicting. The aims of this study were to analyze the neuropsychological pattern of subjects affected by degenerative dementia without evidence of small vessel pathology (DD) and small vessel VaD subjects in the early stages and to investigate differences in the progression of cognitive impairment. Seventy-five patients with probable VaD and 75 patients with probable DD were included...
September 21, 2016: Neurological Sciences
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