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JOURNAL ARTICLE
Antonio Rispo, Alessia Dalila Guarino, Monica Siniscalchi, Nicola Imperatore, Antonella Santonicola, Simona Ricciolino, Roberto de Sire, Benedetta Toro, Nicola Mattia Cantisani, Carolina Ciacci
BACKGROUND: Gluten-free diet (GFD) is the one therapy in coeliac disease (CeD). Unfortunately, some patients adopt GFD before the diagnostic work-up. The guidelines suggest a 14-day gluten intake > 3 gr to get CeD diagnosis, although many subjects refuse this approach. Other evidence showed that the intake of 50 mg/day of gluten for 3 months could be useful for CeD diagnosis. AIMS: We performed a dietary study, administering a low dose of gluten in form of "crackers" (about 60-120 mg of gluten/day) for 3 months, to get a final diagnosis of CeD in subjects already on GFD...
March 22, 2024: Digestive and Liver Disease
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JOURNAL ARTICLE
Antonietta Gerarda Gravina, Raffaele Pellegrino, Giovanna Palladino, Giuseppe Imperio, Andrea Ventura, Alessandro Federico
BACKGROUND: Conversational chatbots, fueled by large language models, spark debate over their potential in education and medical career exams. There is debate in the literature about the scientific integrity of the outputs produced by these chatbots. AIMS: This study evaluates ChatGPT 3.5 and Perplexity AI's cross-sectional performance in responding to questions from the 2023 Italian national residency admission exam (SSM23), comparing results and chatbots' concordance with previous years SSMs...
March 18, 2024: Digestive and Liver Disease
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Massimo Martinelli, Maria Teresa Fioretti, Marina Aloi, Patrizia Alvisi, Serena Arrigo, Claudia Banzato, Matteo Bramuzzo, Angelo Campanozzi, Fortunata Civitelli, Daniela Knafelz, Paolo Lionetti, Antonio Marseglia, Francesca Musto, Lorenzo Norsa, Giuseppe Palumbo, Sara Renzo, Claudio Romano, Naire Sansotta, Caterina Strisciuglio, Erasmo Miele
Anemia is one of the most frequent extra-intestinal manifestations of inflammatory bowel disease. Insidious onset, variability of symptoms and lack of standardized screening practices may increase the risk of underestimating its burden in children with IBD. Despite its relevance and peculiarity in everyday clinical practice, this topic is only dealt with in a few documents specifically for the pediatric field. The aim of the current guidelines is therefore to provide pediatric gastroenterologists with a practical update to support the clinical and therapeutic management of children with IBD and anemia...
March 18, 2024: Digestive and Liver Disease
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EDITORIAL
Yaser Al-Salmay, Ashwani K Singal
No abstract text is available yet for this article.
March 9, 2024: Digestive and Liver Disease
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JOURNAL ARTICLE
Yoon Suk Jung, Mai Thi Xuan Tran, Boyoung Park, Chang Mo Moon
This study aimed to evaluate the association between low-dose aspirin use and the risk of GC and gastric adenoma according to a family history of GC. We conducted a population-based study of 7,596,003 participants screened for GC between 2013 and 2014. Aspirin users and non-users were matched in a 1:1 ratio through propensity score matching (PSM). After PSM, 51,818 participants with a family history of GC and 359,840 without a family history of GC were analyzed (mean follow-up periods: 4.9 ± 0.8 and 4...
March 9, 2024: Digestive and Liver Disease
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JOURNAL ARTICLE
Jinpei Dong, Yu Tian
No abstract text is available yet for this article.
March 9, 2024: Digestive and Liver Disease
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EDITORIAL
Gabriele Capurso, Alberto Malesci
No abstract text is available yet for this article.
March 9, 2024: Digestive and Liver Disease
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REVIEW
G Bazzocchi, E S Corazziari, A Staiano, G Bassotti, M Bellini, G Chiarioni, L D'Alba, E Scarpato
The practice of recto-colonic water irrigation to treat constipation has been used since ancient times with different, uncontrolled, and variably performing methods which have been considered interchangeably all alike. The use of better-performing devices with a standardized methodology is relatively recent, and the term Trans Anal Irrigation (TAI) defines a methodology performed with devices able to control the timing, volume, and pressure of the water introduced into the rectum and colon utilizing a catheter or a cone through the anus...
March 8, 2024: Digestive and Liver Disease
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JOURNAL ARTICLE
Marco Spadaccini, Joel Troya, Kareem Khalaf, Antonio Facciorusso, Roberta Maselli, Alexander Hann, Alessandro Repici
Colorectal cancer is a significant global health concern, necessitating effective screening strategies to reduce its incidence and mortality rates. Colonoscopy plays a crucial role in the detection and removal of colorectal neoplastic precursors. However, there are limitations and variations in the performance of endoscopists, leading to missed lesions and suboptimal outcomes. The emergence of artificial intelligence (AI) in endoscopy offers promising opportunities to improve the quality and efficacy of screening colonoscopies...
March 7, 2024: Digestive and Liver Disease
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JOURNAL ARTICLE
Karoline Anisdahl, Sandre Svatun Lirhus, Asle W Medhus, Bjørn Moum, Hans Olav Melberg, Marte Lie Høivik
BACKGROUND/AIMS: To determine real-world medical and surgical treatment patterns in elderly-onset inflammatory bowel disease in a nationwide cohort, and to investigate associations between frailty and treatment choices. METHODS: Norwegian health registries were used to identify adult-onset (born 1950-1989) and elderly-onset (born 1910-1949) patients with Crohn's disease (CD) and ulcerative colitis (UC) diagnosed 2010-2017 (n = 13,006). Patients were classified as no, low and intermediate/high frailty risk after the Hospital Frailty Risk Score...
March 2, 2024: Digestive and Liver Disease
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JOURNAL ARTICLE
Kyle Scholten, Patrick Twohig, Kaeli Samson, Kevin Brittan, Alexandra Fiedler, Josh Warner, Tomoki Sempokuya, Anna Willet, Thoetchai Bee Peeraphatdit, Marco Olivera
BACKGROUND: Serum phosphatidylethanol (PEth) testing has emerged as a promising biomarker for assessing recent alcohol consumption, surpassing the limitations of self-reported data. Limited clinical data exists comparing PEth levels and patients' reported alcohol intake. AIMS: Compare PEth testing results with self-reported alcohol intake and assesses variables associated with underreporting. METHODS: Single-center retrospective cohort of patients with a diagnosis of chronic liver disease and serum PEth...
March 1, 2024: Digestive and Liver Disease
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JOURNAL ARTICLE
Srinivas Srinidhi Vadlapudi, Anshu Srivastava, Nidhi Saini, Moinak Sen Sarma, Ujjal Poddar, Surender Kumar Yachha
BACKGROUND: Ascites in children is multifactorial and serum ascites albumin gradient (SAAG) ≥1.1 helps differentiate portal hypertension (PHTN) related from non-PHTN ascites. AIMS: We evaluated the aetiology and diagnostic accuracy of SAAG in children with ascites. METHODS: Children with ascites were retrospectively evaluated. Etiological diagnosis was based on clinical presentation and investigations. All cases with ascitic fluid analysis and a definite diagnosis were included for calculating the utility of SAAG...
February 29, 2024: Digestive and Liver Disease
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LETTER
Shunsuke Koga, Wei Du
No abstract text is available yet for this article.
February 29, 2024: Digestive and Liver Disease
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Nicola de Bortoli, Pierfrancesco Visaggi, Roberto Penagini, Bruno Annibale, Federica Baiano Svizzero, Giovanni Barbara, Ottavia Bartolo, Edda Battaglia, Antonio Di Sabatino, Paola De Angelis, Ludovico Docimo, Marzio Frazzoni, Manuele Furnari, Andrea Iori, Paola Iovino, Marco Vincenzo Lenti, Elisa Marabotto, Giovanni Marasco, Aurelio Mauro, Salvatore Oliva, Gaia Pellegatta, Marcella Pesce, Antonino Carlo Privitera, Ilaria Puxeddu, Francesca Racca, Mentore Ribolsi, Erminia Ridolo, Salvatore Russo, Giovanni Sarnelli, Salvatore Tolone, Patrizia Zentilin, Fabiana Zingone, Brigida Barberio, Matteo Ghisa, Edoardo Vincenzo Savarino
Eosinophilic esophagitis (EoE) is a chronic type 2-mediated inflammatory disease of the esophagus that represents the most common eosinophilic gastrointestinal disease. Experts in the field of EoE across Italy (i.e., EoETALY Consensus Group) including gastroenterologists, endoscopists, allergologists/immunologists, and paediatricians conducted a Delphi process to develop updated consensus statements for the management of patients with EoE and update the previous position paper of the Italian Society of Gastroenterology (SIGE) in light of recent evidence...
February 28, 2024: Digestive and Liver Disease
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JOURNAL ARTICLE
Hiroyuki Shibata, Kenta Yamamoto, Takashi Hirose, Satoshi Furune, Naomi Kakushima, Kazuhiro Furukawa, Masanao Nakamura, Takashi Honda, Mitsuhiro Fujishiro, Hiroki Kawashima
INTRODUCTION: Nonampullary duodenal epithelial tumors are rare, but their prevalence is increasing. Various gastrointestinal cancers have been associated with microbiomes. We evaluated the characteristics of the salivary and duodenal microbiomes of patients with nonampullary duodenal epithelial tumors. METHODS: Saliva and biopsy samples from the duodenal bulb and descending portion were obtained from 15 patients with nonampullary duodenal epithelial tumors and 10 controls...
February 26, 2024: Digestive and Liver Disease
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JOURNAL ARTICLE
Shinya Matsumura, Yasuyuki Sai, Kiyoshi Ogiso, Kentaro Suzuki
No abstract text is available yet for this article.
February 24, 2024: Digestive and Liver Disease
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JOURNAL ARTICLE
R Varnier, C Toullec, S Philonenko, A Dupré, P Artru, E Hafliger, A Drouillard, C Torregrosa, S Pernot, P McLellan, T Lecomte, V Moulin, C Lécaille, Y Touchefeu, C Locher, J Taieb, C Coutzac
BACKGROUND: Prior trials validated triplet chemotherapy (Tri-CT) with bevacizumab as first line treatment for metastatic colorectal cancer (mCRC) but real-world data are scarce and practices remain heterogeneous. AIMS: To evaluate Tri-CT +/- bevacizumab efficacy and safety, and to identify factors influencing treatment decisions. METHODS: The COLOTRIP retrospective study enrolled mCRC patients treated from 2014 to 2019 in 14 French centers...
February 24, 2024: Digestive and Liver Disease
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REVIEW
Fabio Farinati, Filippo Pelizzaro
Gastric cancer is a major cause of cancer-related death worldwide, despite the reduction in its incidence. The disease is still burdened with a poor prognosis, particularly in Western countries. The main risk factor is the infection by Helicobacter pylori, classified as a class I carcinogen by the IARC, and It is well-known that primary prevention of gastric cancer can be achieved with the eradication of the infection. Moreover, non-invasive measurement of pepsinogens (PGI and PGI/PGII ratio) allows the identification of patients that should undergo upper gastrointestinal (GI) endoscopy...
February 24, 2024: Digestive and Liver Disease
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JOURNAL ARTICLE
Wenlu Niu, Leheng Liu, Zhixia Dong, Xiongzhu Bu, Fanghao Yao, Jing Wang, Xiaowan Wu, Congying Chen, Tiancheng Mao, Yulun Wu, Lin Yuan, Xinjian Wan, Hui Zhou
BACKGROUND AND PURPOSE: Patients with stage III or IV of operative link for gastric intestinal metaplasia assessment (OLGIM) are at a higher risk of gastric cancer (GC). We aimed to construct a deep learning (DL) model based on magnifying endoscopy with narrow-band imaging (ME-NBI) to evaluate OLGIM staging. METHODS: This study included 4473 ME-NBI images obtained from 803 patients at three endoscopy centres. The endoscopic expert marked intestinal metaplasia (IM) regions on endoscopic images of the target biopsy sites...
February 23, 2024: Digestive and Liver Disease
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Thierry Lecomte, David Tougeron, Romain Chautard, Diane Bressand, Frédéric Bibeau, Benjamin Blanc, Romain Cohen, Jérémie Jacques, Jean-Paul Lagasse, Pierre Laurent-Puig, Come Lepage, Olivier Lucidarme, Jérôme Martin-Babau, Yves Panis, Fabienne Portales, Julien Taieb, Thomas Aparicio, Olivier Bouché
INTRODUCTION: This article is a summary of the French intergroup guidelines regarding the management of non-metastatic colon cancer (CC), revised in November 2022. METHODS: These guidelines represent collaborative work of all French medical and surgical societies involved in the management of CC. Recommendations were graded in three categories (A, B, and C) according to the level of evidence found in the literature published up to November 2022. RESULTS: Initial evaluation of CC is based on clinical examination, colonoscopy, chest-abdomen-pelvis computed tomography (CT) scan, and carcinoembryonic antigen (CEA) assay...
February 20, 2024: Digestive and Liver Disease
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