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Digestive and Liver Disease

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https://www.readbyqxmd.com/read/28512034/diagnostic-yield-of-capsule-endoscopy-versus-magnetic-resonance-enterography-and-small-bowel-contrast-ultrasound-in-the-evaluation-of-small-bowel-crohn-s-disease-systematic-review-and-meta-analysis
#1
REVIEW
Uri Kopylov, Diana E Yung, Tal Engel, Sanju Vijayan, Ofir Har-Noy, Lior Katz, Salvatore Oliva, Tomer Avni, Robert Battat, Rami Eliakim, Shomron Ben-Horin, Anastasios Koulaouzidis
BACKGROUND AND AIMS: Capsule endoscopy (CE), magnetic resonance enterography (MRE) and small bowel (SB) intestinal contrast ultrasound (SICUS) are the modalities of choice for SB evaluation. This study aimed to compare the diagnostic yield (DY) of CE to MRE and SICUS in detection and monitoring of SB CD through meta-analysis of the available literature. METHODS: We performed a systematic literature search for trials comparing the accuracy of CE, MRE and SICUS for detection of active SB inflammation in patients with suspected and/or established CD...
April 27, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28499694/effectiveness-and-safety-of-community-based-treatment-with-sofosbuvir-plus-ribavirin-for-elderly-patients-with-genotype-2-chronic-hepatitis-c
#2
Masanori Atsukawa, Akihito Tsubota, Chisa Kondo, Noritomo Shimada, Hiroshi Abe, Keizo Kato, Tomomi Okubo, Taeang Arai, Norio Itokawa, Etsuko Iio, Yasuhito Tanaka, Katsuhiko Iwakiri
BACKGROUND: The aim of this study was to clarify the effectiveness and safety of sofosbuvir/ribavirin therapy for elderly patients with genotype 2-infected chronic hepatitis C (CHC) in Japan. METHODS: A multicenter, retrospective study evaluated the effectiveness and safety of sofosbuvir/ribavirin based on real-world clinical data. RESULTS: The subjects consisted of 270 patients, 47.0% of whom were aged ≥65 years. The sustained virological response rates in patients aged <65 and ≥65 years were 98...
April 27, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28506472/gadolinium-accumulation-after-contrast-enhanced-magnetic-resonance-imaging-which-implications-in-patients-with-crohn-s-disease
#3
Edoardo Savarino, Vito Chianca, Giorgia Bodini, Domenico Albano, Carmelo Messina, Gian Eugenio Tontini, Luca Maria Sconfienza
Crohn's disease (CD) is a chronic inflammatory condition of the bowel, characterized by an alternation of remission and relapse phases, leading to a progressive intestinal damage with loss of function. Magnetic resonance enterography has been widely used in the past for the evaluation of fistulizing disease, but its use increased over time, being considered helpful in different moments of disease course. Intravenous injection of Gadolinium-based contrast agents has been demonstrated to be crucial to assess mucosal inflammation, transmural involvement, and extraintestinal disease...
April 26, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28499693/a-case-report-of-mysterious-bleeding
#4
Carlo Maria Girelli, Giorgia Colombo
No abstract text is available yet for this article.
April 25, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28487084/application-of-oral-contrast-trans-abdominal-ultrasonography-for-initial-screening-of-gastric-cancer-in-rural-areas-of-china
#5
Li Shen, Chenfei Zhou, Lan Liu, Li Zhang, Dianyuan Lu, Jianrong Cai, Liying Zhao, Rongrong Chu, Junyu Zhou, Jun Zhang
BACKGROUND: The present study is aimed at assessing the efficacy of oral contrast trans-abdominal ultrasonography (OCTU) as an initial screening tool for gastric cancer in rural areas of China. METHODS: All subjects that were enrolled from Chongming County, Shanghai, China. Subjects in the symptomatic group underwent both OCTU and gastroscopic biopsy. OCTU was performed by experienced ultrasonic physicians in a blinded fashion. RESULTS: In the symptomatic group, 643 patients were enrolled; diagnoses included low risk diseases gastritis (68...
April 19, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28487081/a-multidisciplinary-approach-allows-identification-of-a-new-pathogenic-cdh1-germline-missense-mutation-in-a-hereditary-diffuse-gastric-cancer-family
#6
LETTER
Maite Betés, Maite Alonso-Sierra, Victor Valentí, Ana Patiño
No abstract text is available yet for this article.
April 19, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28465092/biliary-plastic-stent-does-not-influence-the-accuracy-of-endoscopic-ultrasound-guided-sampling-of-pancreatic-head-masses-performed-with-core-biopsy-needles
#7
Filippo Antonini, Lorenzo Fuccio, Sara Giorgini, Carlo Fabbri, Leonardo Frazzoni, Marina Scarpelli, Giampiero Macarri
OBJECTIVE: While the presence of biliary stent significantly decreases the accuracy of endoscopic ultrasound (EUS) for pancreatic head cancer staging, its impact on the EUS-guided sampling accuracy is still debated. Furthermore, data on EUS-fine needle biopsy (EUS-FNB) using core biopsy needles in patients with pancreatic mass and biliary stent are lacking. The aim of this study was to evaluate the influence of biliary stent on the adequacy and accuracy of EUS-FNB in patients with pancreatic head mass...
April 15, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28473299/single-synchronous-liver-metastasis-from-merkel-cell-carcinoma-mimicking-a-klatskin-tumor-a-diagnostic-challenge
#8
Giovanni Vennarecci, Antonella Tudisco, Francesca Cancellario d'Alena, Giuseppe M Ettorre
No abstract text is available yet for this article.
April 14, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28487082/esophageal-chemical-clearance-and-baseline-impedance-values-in-patients-with-chronic-autoimmune-atrophic-gastritis-and-gastro-esophageal-reflux-disease
#9
Andrea Tenca, Nicola de Bortoli, Aurelio Mauro, Marzio Frazzoni, Edoardo Savarino, Sara Massironi, Salvatore Russo, Lorenzo Bertani, Santino Marchi, Roberto Penagini
BACKGROUND: The factors influencing new markers of gastro-esophageal reflux disease detected by impedance-pH monitoring - mean nocturnal baseline impedance (MNBI) and post-reflux swallow-induced peristaltic wave (PSPW) index - need to be evaluated. AIM: To compare endoscopy-negative heartburn with chronic autoimmune atrophic gastritis (CAAG). MATERIALS AND METHODS: 24 patients with CAAG, 25 with non-erosive reflux disease (NERD) and 25 with functional heartburn (FH) were included...
April 13, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28460756/do-not-forget-to-culture
#10
Berrie Meijer, Nanne K H de Boer
No abstract text is available yet for this article.
April 13, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28473302/glassy-droplet-inclusions-within-the-cytoplasm-of-kupffer-cells-a-novel-ultrastructural-feature-for-the-diagnosis-of-pediatric-autoimmune-hepatitis
#11
Joanna Maria Lotowska, Maria Elzbieta Sobaniec-Lotowska, Urszula Daniluk, Dariusz Marek Lebensztejn
Since Kupffer cells/macrophages (KCs/MPs) may be involved in the pathogenesis of autoimmune hepatitis (AIH), this pioneer study was undertaken to evaluate KCs/MPs in pediatric AIH in transmission-electron microscope. METHODS: Ultrastructural analyses were performed using liver biopsies from 14 children with clinicopathologically diagnosed AIH. RESULTS: In all AIH children, ultrastructural findings revealed changes in the cells lining sinusoidal vessels, especially KCs/MPs and endothelial cells...
April 12, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28456519/treatment-of-hepatitis-c-virus-infection-in-italy-a-consensus-report-from-an-expert-panel
#12
Mauro Viganò, Carlo Federico Perno, Antonio Craxì
Hepatitis C virus (HCV) infection remains one of the main causes of chronic liver disease worldwide. The advent of direct-acting antivirals (DAAs) has significantly improved the course of patients with chronic HCV infection (CHC), due to the ability of these drugs to achieve high rates of sustained virological response (SVR). These exceedingly high rates of SVR and the excellent safety data have been confirmed in real life practice. Evolving guidelines have been issued by national and international scientific societies in accordance with the progression of clinical knowledge and the availability of new DAAs...
April 12, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28454853/value-of-cross-sectional-imaging-in-assessing-active-crohn-s-disease-before-stoma-reversal
#13
Bastien Dirrenberger, Isabelle Clerc-Urmès, Adeline Germain, Laurent Bresler, Pablo Olivera, Laura Martelli, Silvio Danese, Cédric Baumann, Valérie Laurent, Laurent Peyrin-Biroulet
BACKGROUND: There are currently no guidelines on the need to assess disease activity before stoma reversal in Crohn's disease (CD). We sought to determine the value of cross-sectional imaging for detecting active CD before stoma reversal. METHODS: 38 CD patients underwent cross-sectional imaging before stoma reversal. CD activity was blindly evaluated by an independent radiologist. Postoperative outcomes were recorded. RESULTS: Before stoma reversal, cross-sectional imaging identified active CD in 20 of the 38 study participants (52...
April 11, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28457904/collagenous-colitis-requirement-for-high-dose-budesonide-as-maintenance-treatment
#14
Fernando Fernandez-Bañares, Marta Piqueras, Danila Guagnozzi, Virginia Robles, Alexandra Ruiz-Cerulla, María José Casanova, Javier P Gisbert, David Busquets, Yolanda Arguedas, Angeles Pérez-Aisa, Luis Fernández-Salazar, Alfredo J Lucendo
BACKGROUND: Controlled studies show high efficacy of budesonide in inducing short-term clinical remission in collagenous colitis (CC), but relapses are common after its withdrawal. AIM: To evaluate the need for high-dose budesonide (≥6mg/d) to maintain clinical remission in CC. METHODS: Analysis of a multicentre retrospective cohort of 75 patients with CC (62.3±1.5years; 85% women) treated with budesonide in a clinical practice setting between 2013 and 2015...
April 10, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28487085/splenic-hematoma-a-rare-complication-of-colonoscopy
#15
LETTER
Thanh-Truc Le, Mohammad Bilal, Ali Hashmi, Sreeram Parupudi
No abstract text is available yet for this article.
April 9, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28473300/allelic-frequencies-of-the-hs1-2-enhancer-within-the-immunoglobulin-heavy-chain-region-in-dayton-ohio-patients-screened-for-celiac-disease-with-duodenal-biopsy
#16
Jing Liu, Rebecca A Law, Paul G Koles, Jonathan C Saxe, Michael Bottomley, Courtney E W Sulentic
BACKGROUND: Genetic and environmental factors contribute to the development of celiac disease (CD), but specific genetic predisposing factors remain poorly understood. One candidate is allele 2 of the hs1.2 enhancer within the immunoglobulin heavy chain region. In humans, there are four possible alleles and a previous study of an Italian cohort demonstrated a significantly increased frequency of allele 2 in patients with CD. AIMS: The purpose of the current study was to determine if a similar association between allele 2 and CD exists in an American population from Dayton, OH...
April 9, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28454854/technological-advances-for-improving-adenoma-detection-rates-the-changing-face-of-colonoscopy
#17
REVIEW
Sauid Ishaq, Keith Siau, Elizabeth Harrison, Gian Eugenio Tontini, Arthur Hoffman, Seth Gross, Ralf Kiesslich, Helmut Neumann
Worldwide, colorectal cancer is the third commonest cancer. Over 90% follow an adenoma-to-cancer sequence over many years. Colonoscopy is the gold standard method for cancer screening and early adenoma detection. However, considerable variation exists between endoscopists' detection rates. This review considers the effects of different endoscopic techniques on adenoma detection. Two areas of technological interest were considered: (1) optical technologies and (2) mechanical technologies. Optical solutions, including FICE, NBI, i-SCAN and high definition colonoscopy showed mixed results...
April 9, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28487083/hcv-clearance-after-direct-acting-antivirals-in-patients-with-cirrhosis-by-stages-of-liver-impairment-the-ital-c-network-study
#18
Antonio Massimo Ippolito, Michele Milella, Vincenzo Messina, Fabio Conti, Raffaele Cozzolongo, Filomena Morisco, Giuseppina Brancaccio, Michele Barone, Teresa Santantonio, Chiara Masetti, Paolo Tundo, Antonina Smedile, Vito Carretta, Pietro Gatti, Antonio Patrizio Termite, Maria Rosa Valvano, Giuseppe Bruno, Claudia Fabrizio, Pietro Andreone, Marianna Zappimbulso, Giovanni Battista Gaeta, Nicola Napoli, Luca Fontanella, Gianfranco Lauletta, Giuseppe Cuccorese, Antonio Metrangolo, Ruggiero Francavilla, Emanuela Ciracì, Salvatore Rizzo, Angelo Andriulli
BACKGROUND: Sustained virological response (SVR12) rates at 12 weeks after treatment for HCV-infected patients with decompensated cirrhosis are used when referring to those with moderate functional impairment, while few data are available for those with more severe impairment. The use of the cirrhosis staging system proposed by D'Amico might provide new insights on timing for antiviral therapy. METHODS: We investigated efficacy (SVR12), safety, and post-treatment variations in clinical and laboratory parameters in 2612 patients with advanced fibrosis (n=575) or cirrhosis (n=2037)...
April 8, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28483419/rescue-dilation-assisted-cholangioscopic-stone-extraction-dacse-after-dase-failure
#19
Vincent Zimmer
No abstract text is available yet for this article.
April 8, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28462888/blood-sucking-hookworm-under-narrow-band-imaging
#20
Surinder S Rana, Ravi Sharma, Vishal Sharma, Rajesh Gupta
No abstract text is available yet for this article.
April 8, 2017: Digestive and Liver Disease
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