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Digestive and Liver Disease

Georgios Giannakopoulos, Hans Verbaan, Inga-Lill Friis-Liby, Per Sangfelt, Nils Nyhlin, Sven Almer
BACKGROUND: Data on rescue treatment of autoimmune hepatitis in patients that fail standard treatment are sparse. AIMS: To report our long-term experience with mycophenolate mofetil. METHODS: Retrospective study in 22 patients with autoimmune hepatitis who failed azathioprine and prednisolone due to adverse events (n = 14, 64%), lack of remission (n = 5, 23%) or a combination (n = 3, 13%). RESULTS: Mycophenolate mofetil was started at a dose of 20 mg/kg/day and increased to a maximum of 3 g/day...
October 12, 2018: Digestive and Liver Disease
Roberta Maselli, Piera Alessia Galtieri, Milena Di Leo, Elisa Chiara Ferrara, Andrea Anderloni, Silvia Carrara, Elena Vanni, Benedetto Mangiavillano, Alfredo Genco, Sameer Al Awadhi, Lorenzo Fuccio, Cesare Hassan, Alessandro Repici
BACKGROUND AND STUDY AIMS: Endoscopic submucosal dissection (ESD), a minimally invasive treatment for early gastrointestinal (GI) cancer, is considered challenging and risky in the colorectum. As such, most patients undergoing ESD are hospitalized due to the perceived increased risk of adverse events. The aim of this study was to compare the costs, safety and efficacy of colorectal-ESD in an outpatient vs inpatient setting in a tertiary level center. METHODS: This is a retrospective study on consecutive patients admitted for colorectal-ESD...
October 12, 2018: Digestive and Liver Disease
G Andrisani, P Soriani, M Manno, M Pizzicannella, F Pugliese, M Mutignani, R Naspetti, L Petruzziello, F Iacopini, C Grossi, P Lagoussis, S Vavassori, F Coppola, A La Terra, S Ghersi, P Cecinato, G De Nucci, R Salerno, M Pandolfi, G Costamagna, F M Di Matteo
BACKGROUND AND AIM: Endoscopic full-thickness resection(EFTR) with FTRD® in colo-rectum may be useful for several indications.The aim was to assess its efficacy and safety. MATERIAL AND METHODS: In this retrospective multicenter study 114 patients were screened; 110 (61M/49F, mean age 68 ± 11 years, range 20-90) underwent EFTR using FTRD® . Indications were:residual/recurrent adenoma (39), incomplete resection at histology (R1 resection) (26), non-lifting lesion (12), adenoma involving the appendix (2) or diverticulum (2), subepithelial lesions(10), suspected T1 carcinoma (16), diagnostic resection (3)...
October 12, 2018: Digestive and Liver Disease
Lucille Quénéhervé, Caroline Dagouat, Marianne Le Rhun, Enrique Perez-Cuadrado Robles, Emilie Duchalais, Stanislas Bruley des Varannes, Yann Touchefeu, Nicolas Chapelle, Emmanuel Coron
BACKGROUND: Sigmoid volvulus is a common cause of colonic obstruction in old and frail patients. Its standard management includes the endoscopic detorsion of the colonic loop, followed by an elective sigmoidectomy to prevent recurrence. However, these patients are often poor candidates for surgery. AIM: The aim of this study was to compare death rate between elective sigmoidectomy and conservative management following endoscopic detorsion for sigmoid volvulus. METHODS: The medical records of 83 patients undergoing endoscopic detorsion of a sigmoid volvulus from 2008 to 2014 were retrospectively reviewed...
October 11, 2018: Digestive and Liver Disease
Mafalda Sousa, Rolando Pinho, Luísa Proença, Jaime Rodrigues, João Silva, Catarina Gomes, João Carvalho
BACKGROUND AND AIMS: The guidelines by the American Society for Gastrointestinal Endoscopy (ASGE) suggest that in patients with gallbladder in situ, endoscopic retrograde cholangiopancreatography (ERCP) should be performed in the presence of high-risk criteria for choledocholithiasis, after biochemical tests and abdominal ultrasound. There are no specific recommendations for cholecystectomized patients. The aim of this study was to evaluate the applicability of ASGE criteria for ERCP in cholecystectomized patients with suspected choledocholithiasis...
October 6, 2018: Digestive and Liver Disease
Pedro Moutinho-Ribeiro, Julio Iglesias-Garcia, Rui Gaspar, Guilherme Macedo
Pancreatic cancer (PC) is one of the deadliest cancers with a 5-year overall survival of less than 6%. Due to its insidious clinical course and unspecific symptoms, the diagnosis is usually late, with only 15-20% patients presenting with potentially curable disease. It is, therefore, extremely important to identify patients with PC at early stages of the disease when tumors may be amenable to surgical resection. For unresectable and borderline resectable PC it is consensual to perform a biopsy to have a cyto/histological confirmation of malignancy before treatment...
October 5, 2018: Digestive and Liver Disease
Maria Lia Scribano, Flavio Caprioli, Andrea Michielan, Antonella Contaldo, Antonino Carlo Privitera, Rosa Maria Bozzi, Emma Calabrese, Fabiana Castiglione, Antonio Francesco Ciccaglione, Gianfranco Delle Fave, Giorgia Bodini, Giuseppe Costantino, Robert Horne, Silvia Saettone, Paolo Usai, Piero Vernia, Sara Di Fino, Giuliana Gualberti, Michela di Fonzo, Rocco Merolla, Ambrogio Orlando
The MARS-5 (Medication Adherence Report Scale) was developed in English. The aim of this project was to analyse the MARS-5I (© Prof Rob Horne) psychometric properties and to identify whether its Italian translation is suitable for assessing medication adherence in Crohn Disease (CD) Italian patients. The MARS was translated and linguistically validated in Italian. The MARS-5I was used for evaluating medication adherence in the SOLE study, conducted in Italy on 552 subjects with CD. In order to un-bias the questionnaire results from the effects of treatment change and/or effectiveness, the analyses were performed on the 277 patients whose disease activity remained stable, selected among the 371 patients who maintained the same treatment between two consecutive visits...
October 4, 2018: Digestive and Liver Disease
Jian-Wei Yun, Wei Zhu, De-Kui Zhang
No abstract text is available yet for this article.
October 4, 2018: Digestive and Liver Disease
Italian Association For The Study Of The Liver Aisf
This report summarizes the clinical features and the indications for treating HCV infection in immunocompromised and transplanted patients in the Direct Acting Antiviral drugs era.
October 1, 2018: Digestive and Liver Disease
Mattia Crespi, Ilaria Ghidotti, Giorgia Bodini, Manuele Furnari, Elisa Marabotto, Edoardo G Giannini
No abstract text is available yet for this article.
October 1, 2018: Digestive and Liver Disease
Ba D Nguyen
No abstract text is available yet for this article.
September 29, 2018: Digestive and Liver Disease
Zhi-Bin Liao, Xiao-Long Tan, Ke-Shuai Dong, Hong-Wei Zhang, Xiao-Ping Chen, Liang Chu, Bi-Xiang Zhang
BACKGROUND: Increasing evidence indicates that aberrant micro (mi)RNA-448 expression plays a critical role in the progression of several human cancers. However, the function of miRNA-448 in hepatocellular carcinoma (HCC) has not been fully investigated. METHODS: miRNA-448 expression levels in HCC tissues, adjacent non-cancerous tissues (ANTs), and HCC cell lines were examined by quantitative real-time polymerase chain reaction (qRT-PCR). HCC cells were treated with a miRNA-448 mimic or inhibitor, followed by cell viability measurements with the CCK-8 assay...
September 28, 2018: Digestive and Liver Disease
Massimo Iavarone, Federica Invernizzi
No abstract text is available yet for this article.
September 27, 2018: Digestive and Liver Disease
Elena Bolzacchini, Alessandro Tuzi, Diego De Palma, Graziella Pinotti
No abstract text is available yet for this article.
September 27, 2018: Digestive and Liver Disease
Shin Fujioka, Katsuya Hirakawa, Aya Fujita, Motohiro Esaki
No abstract text is available yet for this article.
September 27, 2018: Digestive and Liver Disease
Nicole Brighi, Giuseppe Lamberti, Ilaria Maggio, Lisa Manuzzi, Claudio Ricci, Riccardo Casadei, Donatella Santini, Cristina Mosconi, Andrea Lisotti, Valentina Ambrosini, Maria Abbondanza Pantaleo, Davide Campana
BACKGROUND: Somatostatin analogs are the backbone of neuroendocrine neoplasms treatment. Biliary stone disease is a potentially severe adverse event of somatostatin analogs: an increased incidence has been reported in somatostatin analogs-treated acromegalic patients, but studies on patients with neuroendocrine neoplasms are lacking. AIMS: To evaluate biliary stone disease incidence and associated factors in a large series of patients treated with somatostatin analogs for neuroendocrine neoplasms...
September 24, 2018: Digestive and Liver Disease
Amar S Bhogal, Michele De Rui, Donatella Pavanello, Ilias El-Azizi, Sadia Rowshan, Piero Amodio, Sara Montagnese, Ali R Mani
BACKGROUND: Liver cirrhosis is associated with reduced heart rate variability (HRV), which indicates impaired integrity of cardiovascular control in this patient population. There are several different indices for HRV quantification. The present study was designed to: 1) determine which of the HRV indices is best at predicting mortality in patients with cirrhosis; 2) verify if such ability to predict mortality is independent of the severity of hepatic failure. METHODS: Ten minutes electrocardiogram was recorded in 74 patients with cirrhosis...
September 24, 2018: Digestive and Liver Disease
Roberto Di Mitri, Filippo Mocciaro, Ambra Bonaccorso, Elisabetta Conte
No abstract text is available yet for this article.
September 22, 2018: Digestive and Liver Disease
Takeshi Ogura, Atsushi Okuda, Akira Miyano, Miyuki Imanishi, Nobu Nishioka, Masanori Yamada, Tadahiro Yamda, Rieko Kamiyama, Daisuke Masuda, Kazuhide Higuchi
BACKGROUND: Gastric cancer is sometimes complicated by obstructive jaundice. However, ERCP may be challenging in patients who have advanced gastric cancer, or recurrent gastric cancer after surgical resection that is complicated by obstructive jaundice. In such cases, percutaneous transhepatic biliary drainage (PTBD) is considered. Recently, EUS-guided biliary drainage (EUS-BD) has been developed. We conducted a retrospective study to compare the efficacy of EUS-BD and PTBD in patients with obstructive jaundice due to gastric cancer...
September 22, 2018: Digestive and Liver Disease
Andrea Casadei Gardini, Francesco Giuseppe Foschi, Fabio Conti, Elisabetta Petracci, Ranka Vukotic, Giorgia Marisi, Federica Buonfiglioli, Giovanni Vitale, Federico Ravaioli, Stefano Gitto, Gabriella Verucchi, Marco Lenzi, Luigi Bolondi, Giuseppe Mazzella, Stefano Brillanti, Pietro Andreone
BACKGROUND: Unexpectedly high occurrence or recurrence rate of hepatocellular carcinoma (HCC) has been observed in patients with chronic hepatitis C receiving direct-acting antivirals (DAAs) therapy. AIMS: We evaluated the predictive value of albumin-bilirubin (ALBI) score and immune-inflammation indicators to identify the risk of occurrence or recurrence of HCC in patients treated with DAAs in a real life setting. METHODS: In this retrospective cohort study, we analysed data from 514 patients with cirrhosis who were prospectively enrolled for treatment with DAAs...
September 22, 2018: Digestive and Liver Disease
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