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Digestive and Liver Disease

Franco Armelao, Riccardo Pertile, Gianni Miori, Renzo Franch, Ivo Avancini, Alberto Meggio, Gaia Franceschini, Cecilia Pravadelli, Chiara Tieppo, Katia Faitini, Davide Giacomin, Pier Giuseppe Orlandi, Enrico Tasini, Giovanni de Pretis
BACKGROUND AND AIMS: There are few prospective data about the use of surveillance colonoscopy and the risk of recurrent neoplasia in first degree relatives (FDRs) of colorectal cancer (CRC) patients. We examined the use and yield of surveillance colonoscopy in a population-based screening program (Trentino, Italy) METHODS: 1252 FDRs have been included in this study. We calculated compliance (percentage of FDRs who underwent surveillance colonoscopy among those eligible), appropriateness of colonoscopy (appropriate if performed within 6 months of the guidelines recommended interval) and diagnostic yield for neoplasia...
February 21, 2018: Digestive and Liver Disease
Asim Shuja, Amie Deutch
No abstract text is available yet for this article.
February 20, 2018: Digestive and Liver Disease
Antonio Pierro, Fabio Rotondi, Maria De Ninno, Giuseppina Sallustio
No abstract text is available yet for this article.
February 16, 2018: Digestive and Liver Disease
Nobuya Kobayashi, Hirohito Mori, Hideki Kobara, Tsutomu Masaki
No abstract text is available yet for this article.
February 13, 2018: Digestive and Liver Disease
Elisabetta Degasperi, Alessio Aghemo, Stefania Paolucci, Roberta D'Ambrosio, Marta Borghi, Riccardo Perbellini, Federica Novazzi, Stella De Nicola, Giovanna Lunghi, Fausto Baldanti, Pietro Lampertico
BACKGROUND: Ombitasvir/paritaprevir-ritonavir (OBT/PTV-r) plus ribavirin (RBV) for 12 weeks in hepatitis C virus (HCV) genotype 4 patients with advanced fibrosis has been only investigated in clinical trials. AIMS: To assess safety and efficacy of OBT/PTV-r + RBV for 12 weeks in real-life HCV-4 patients with advanced fibrosis. METHODS: HCV-4 patients with advanced fibrosis consecutively receiving OBT/PTV-r + RBV for 12 weeks in a single center were enrolled...
February 12, 2018: Digestive and Liver Disease
Alessandro Mantovani
No abstract text is available yet for this article.
February 12, 2018: Digestive and Liver Disease
Abhinav Vasudevan, Lauren Beswick, Antony B Friedman, Alicia Moltzen, James Haridy, Ajay Raghunath, Miles Sparrow, Daniel van Langenberg
AIMS: To assess the utility and tolerability of thiopurine-allopurinol co-therapy in inflammatory bowel disease (IBD) patients with intolerance to thiopurine monotherapy. METHODS: A retrospective observational study assessed cases of thiopurine intolerance then switched to thiopurine allopurinol co-therapy between 2011 and 2015 at two centres. Indications for switch, dosing and subsequent clinical outcomes (including thiopurine persistence) were recorded. RESULTS: Of 767 patients on thiopurines for IBD, 89 (12%) were switched to co-therapy for intolerance...
February 10, 2018: Digestive and Liver Disease
Fabia Attili, Mihai Rimbaş, Alberto Fantin, Carlo Fabbri, Silvia Carrara, Luca Di Maurizio, Giulia Gibiino, Alessandro Repici, Frediano Inzani, Antonio Gasbarrini, Guido Costamagna, Alberto Larghi
OBJECTIVE: Procurement of tissue core biopsy may overcome some of the limitations of EUS-FNA. We aimed at assessing the safety, core procurement yield and diagnostic accuracy of two novel available histology needles. METHODS: Data from consecutive patients with solid lesions who underwent EUS-FNB using the 25G-22G SharkCore™ needles were retrieved from 4 tertiary-care centers database. RESULTS: 146 patients (mean age 64 ± 12 years; M/F, 76/68) with 156 lesions (114 pancreatic) were identified...
February 8, 2018: Digestive and Liver Disease
Shoichi Yoshimizu, Toshiyuki Yoshio, Akiyoshi Ishiyama, Tomohiro Tsuchida, Yusuke Horiuchi, Masami Omae, Toshiaki Hirasawa, Takao Asari, Keisho Chin, Junko Fujisaki
BACKGROUND: For esophageal squamous cell carcinoma (ESCC) with submucosal (SM) invasion, surgery is the standard treatment. Definitive chemoradiotherapy (D-CRT) is a less invasive alternative option, but sometimes results in locoregional failure. AIM: To examine whether endoscopic resection for primary lesion removal combined with chemoradiotherapy (ER-CRT) reduces locoregional failure rates in cases of ESCC with SM invasion. METHODS: We retrospectively compared clinical outcomes between ER-CRT and D-CRT in patients diagnosed with ESCC with SM invasion between 2003 and 2014...
February 7, 2018: Digestive and Liver Disease
Mauro Bortolotti, Lucia Zanoni, Maurizio Levorato
No abstract text is available yet for this article.
February 5, 2018: Digestive and Liver Disease
Takeshi Ogura, Yoshitaka Kurisu, Akira Miyano, Kazuhide Higuchi
No abstract text is available yet for this article.
February 5, 2018: Digestive and Liver Disease
Tingxue Song, Martin Rössle, Fuliang He, Fuquan Liu, Xiaozhong Guo, Xingshun Qi
BACKGROUND: Hepatorenal syndrome is a severe complication of advanced liver diseases with a dismal prognosis. AIMS: This systematic review and meta-analysis aims to explore the efficacy and safety of transjugular intrahepatic portosystemic shunt for the treatment of hepatorenal syndrome. METHOD: Publications were searched via PubMed and EMBASE databases. The pooled proportion and mean difference were calculated by using a random-effect model...
February 5, 2018: Digestive and Liver Disease
Peng Diao, Julien Langrand-Escure, Max-Adrien Garcia, Sophie Espenel, Amel Rehailia-Blanchard, Blandine de Lavigerie, Nicolas Vial, Guy de Laroche, Alexis Vallard, Nicolas Magné
BACKGROUND AND PURPOSE: There is paucity of data on the efficacy and toxicity of radiotherapy in rectal cancer (RC) elderly patients. The objective was to identify management strategies and resulting outcomes in RC patients ≥70 years undergoing radiotherapy. MATERIAL AND METHODS: A retrospective study included consecutive RC patients ≥70 years undergoing rectal radiotherapy. RESULTS: From 2004-2015, 340 RC patients underwent pre-operative (n = 238; 70%), post-operative (n = 41, 12%), or exclusive (n = 61, 18%) radiotherapy, with a median age of 78...
February 3, 2018: Digestive and Liver Disease
Aziz Zaanan, Emmanuelle Samalin, Thomas Aparicio, Olivier Bouche, Pierre Laurent-Puig, Sylvain Manfredi, Pierre Michel, Carole Monterymard, Marie Moreau, Philippe Rougier, David Tougeron, Julien Taieb, Christophe Louvet
INTRODUCTION: In advanced gastric cancer, doublet regimen including platinum salts and fluoropyrimidine is considered as a standard first-line treatment. The addition of docetaxel (75 mg/m2  q3w) to cisplatin (75 mg/m2  q3w) and 5-fluorouracil has been shown to improve efficacy. However, this regimen (DCF) was associated with frequent severe toxicities (including more complicated neutropenia), limiting its use in clinical practice. Interesting alternative docetaxel-based regimens have been developed that need to be validated...
February 3, 2018: Digestive and Liver Disease
Nahla E El-Ashmawy, Naglaa F Khedr, Hoda A El-Bahrawy, Omnia B Hamada
BACKGROUND: Oxidative stress and inflammation may play a key role in the pathogenesis of acute pancreatitis (AP). Lycopene, a natural carotenoid, has antioxidant scavenger capacity and inhibits inflammation in many experimental models. AIM: The study was designed to investigate whether lycopene can ameliorate l-arginine-induced pancreatitis in rats and to elucidate the underlying molecular mechanisms of these effects. METHODS: Forty-eight adult male Wistar rats were divided into: control group (vehicle, orally, 10 days), AP group (3 g/kg l-arginine, single i...
February 2, 2018: Digestive and Liver Disease
Amedeo Lonardo, Giovanni Targher
No abstract text is available yet for this article.
February 2, 2018: Digestive and Liver Disease
Cláudia Camila Dias, Francisco Portela, Samuel Fernandes, Paula Ministro, Paula Lago, Isadora Rosa, Luis Correia, Fernando Magro
BACKGROUND: Abdominal surgery and immunosuppressive pharmacological treatments are two different therapeutic options used to manage Crohn disease. This study aimed to determine whether the timing of these interventions had an impact on patients' prognosis. METHOD: This manuscript entails a retrospective analysis of a multicentric cohort involving 498 CD patients that had bowel surgery after diagnosis and prior to immunosuppression treatments. Two endpoints were considered: the occurrence of disabling disease and the need to undergo further bowel surgeries...
February 1, 2018: Digestive and Liver Disease
Michele Barone, Endrit Shahini, Andrea Iannone, Maria Teresa Viggiani, Valeria Corvace, Mariabeatrice Principi, Alfredo Di Leo
BACKGROUND: A critical flicker frequency (CFF) ≤39 Hz identifies cirrhotic patients with minimal hepatic encephalopathy (mHE) and predicts the risk of both overt hepatic encephalopathy (oHE) and mortality in patients with previous episodes of decompensation and/or oHE. AIMS: Herein, we evaluated the effectiveness of CFF in predicting the first episode of oHE and survival in cirrhotics who had never experienced an episode of oHE. METHODS: Our cohort study of 134 patients and 150 healthy subjects were examined...
January 31, 2018: Digestive and Liver Disease
Stefania Gioia, Silvia Nardelli, Chiara Pasquale, Ilaria Pentassuglio, Valeria Nicoletti, Francesca Aprile, Manuela Merli, Oliviero Riggio
BACKGROUND: The knowledge of natural history of patients with portal hypertension (PH) not due to cirrhosis is less well known than that of cirrhotic patients. AIM: To describe the clinical presentation and the outcomes of 89 patients with non-cirrhotic PH (25 with non-cirrhotic portal hypertension, INCPH, and 64 with chronic portal vein thrombosis, PVT) in comparison with 77 patients with Child A cirrhosis. METHODS: The patients were submitted to a standardized clinical, laboratory, ultrasonographic and endoscopic follow-up...
January 31, 2018: Digestive and Liver Disease
Markku Voutilainen, Nina Hutri-Kähönen, Päivi Tossavainen, Taina Sipponen, Niina Pitkänen, Tomi Laitinen, Eero Jokinen, Tapani Rönnemaa, Jorma S A Viikari, Olli T Raitakari, Markus Juonala
BACKGROUND AND AIMS: Several genetic and environmental risk factors have been linked to chronic inflammatory bowel disease (IBD). The incidence of IBD has significantly increased in developed countries during last decades. The aim of the present study was to examine childhood risk factors for subsequent IBD diagnosis in a longitudinal cohort study of children and adolescents. METHODS: A Finnish study population consisting of 3551 children and adolescents originally evaluated as part of the Cardiovascular Risk in Young Finns study in 1980...
January 31, 2018: Digestive and Liver Disease
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