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Digestive and Liver Disease

Anthony Buisson, Bruno Pereira, Marion Goutte, Maud Reymond, Christophe Allimant, Hélène Obritin-Guilhen, Gilles Bommelaer, Constance Hordonneau
BACKGROUND: Magnetic resonance index of activity (MaRIA) and Clermont score are currently the two main MRI indices that have been validated compared to endoscopy in Crohn's disease (CD). AIMS: To compare the accuracy of MaRIA and Clermont score in assessing CD mucosal healing. METHODS: Fourty-four CD patients underwent prospectively and consecutively MRI and colonoscopy. RESULTS: Considering 207 segments, MaRIA>7 and Clermont score>8...
August 31, 2017: Digestive and Liver Disease
Francesco Callea
No abstract text is available yet for this article.
August 24, 2017: Digestive and Liver Disease
Peter Bossuyt, Lieven Pouillon, Guillaume Bonnaud, Silvio Danese, Laurent Peyrin-Biroulet
Patients with inflammatory bowel disease need close monitoring for an optimal disease management. For this, e-health technologies are promising tools. But the current evidence for the implementation of e-health in inflammatory bowel disease is weak. For this a critical evaluation of the existing evidence is presented. Furthermore some essential conditions need to be full-filled. We need a robust digital infrastructure that is workable for the patient and the healthcare provider. Important legal issues need to be solved to protect the patient...
August 24, 2017: Digestive and Liver Disease
Rui Morais, Hélder Cardoso, Marco Silva, Guilherme Macedo
No abstract text is available yet for this article.
August 24, 2017: Digestive and Liver Disease
Ihab I El Hajj, Jeffrey J Easler, Stuart Sherman, Mohammad Al-Haddad
No abstract text is available yet for this article.
August 24, 2017: Digestive and Liver Disease
Carlos Rodríguez-Escaja, Elena Carreño, Joan B Gornalsc
No abstract text is available yet for this article.
August 23, 2017: Digestive and Liver Disease
Webber Chan, Hang Hock Shim, Miao Shan Lim, Fatimin Leila Bahjin Sawadjaan, Sangeetha Poongunam Isaac, Sai Wei Chuah, Rupert Leong, Chris Kong
BACKGROUND: Inflammatory bowel disease (IBD) frequently results in disability. The relevance of psychological effects in causing disability, and whether disability occurs similarly in non-Western cohorts is as yet unknown. AIM: We assessed the relationship between symptoms of anxiety and depression, quality of life and disability in a Singaporean IBD cohort and their predictors. METHODS: Cross-sectional study. We assessed consecutive IBD subjects' IBD-Disability Index (IBD-DI), Hospital Anxiety and Depression Scale (HADS), and IBD questionnaire (IBDQ)...
August 14, 2017: Digestive and Liver Disease
Andrea Lisotti, Marta Serrani, Giancarlo Caletti, Pietro Fusaroli
No abstract text is available yet for this article.
August 14, 2017: Digestive and Liver Disease
Betty P Morales, Ramon Planas, Ramon Bartoli, Rosa M Morillas, Margarita Sala, Irma Casas, Carolina Armengol, Helena Masnou
BACKGROUND & AIMS: Decompensated cirrhosis patients have an elevated incidence of early readmission, mortality and economic burden. The aims of HEPACONTROL were to reduce early readmission and to evaluate its impact on mortality and emergency department visits. PATIENTS AND METHODS: Quasi-experimental study with control group which compared two cohorts of patients discharged after being admitted for cirrhosis-related complications. A prospective cohort (n=80), who followed the HEPACONTROL program, which began with a follow-up examination seven days after discharge at the Hepatology Unit Day Hospital and a retrospective cohort of patients (n=112), who had been given a standard follow-up...
August 13, 2017: Digestive and Liver Disease
Mingxing Huang, Jessica Williams, Bo Kong, Yan Zhu, Guodong Li, Zhe Zhu, Grace L Guo
The leading cause of acute liver failure (ALF) is hepatotoxicity from acetaminophen (APAP) overdose. However, limited options are available to treat this ALF so stimulating liver regeneration maybe a potential treatment. Our previous study has shown that fibroblast growth factor 15 (FGF15) plays a crucial role in liver regeneration, but the roles of FGF15 in liver injury and repair following APAP-overdose are unknown. In this study, treatment of FGF15 knockout (KO) male mice with APAP at 200, 250, or 300mg/kg significantly increased the degree of liver injury compared to wild type (WT) mice...
August 12, 2017: Digestive and Liver Disease
Panagiotis Zis, Dasappaiah Ganesh Rao, Ptolemaios Georgios Sarrigiannis, Pascale Aeschlimann, Daniel P Aeschlimann, David Sanders, Richard A Grünewald, Marios Hadjivassiliou
BACKGROUND: TG6 antibodies have been shown to be a marker of gluten ataxia but their presence in the context of other neurological manifestations of gluten sensitivity has not been explored. We investigated the presence of TG6 antibodies in gluten neuropathy (GN), defined as as an otherwise idiopathic peripheral neuropathy associated with serological markers of gluten sensitivity (one or more of antigliadin IgG and/or IgA, endomysial and transglutaminase-2 antibodies). METHODS: This was a cross-sectional study conducted at the Sheffield Institute of Gluten Related Diseases, Royal Hallamshire Hospital, Sheffield, UK...
August 10, 2017: Digestive and Liver Disease
Fanny Le Pimpec, Grégoire Moutel, Christine Piette, Astrid Lièvre, Jean-François Bretagne
BACKGROUND: The reasons for participation in fecal immunological testing (FIT) of subjects who were previously non-respondents to guaiac fecal occult blood testing (g-FOBT) have not been assessed. POPULATION AND METHODS: We aimed to determine the reasons for current compliance with FIT among non-responders to g-FOBT, termed "converts", in a French district. A questionnaire was returned by 170 converts aged from 55 to 75 years (response rate 75.2% after exclusions)...
August 10, 2017: Digestive and Liver Disease
Anna Negroni, Eleonora Colantoni, Maria Pierdomenico, Francesca Palone, Manuela Costanzo, Salvatore Oliva, Antonio Tiberti, Salvatore Cucchiara, Laura Stronati
BACKGROUND: Necroptosis is an inflammatory form of programmed cell death requiring receptor-interacting protein kinase 3 (RIP3) and mixed lineage kinase domain-like protein (MLKL). AIMS: The aim of this study is to examine in depth in vitro and ex vivo the contribution of necroptosis to intestinal inflammation. METHODS: In vitro: we used an intestinal cell line, HCT116RIP3, produced in our laboratory and overexpressing RIP3. Ex vivo: intestinal mucosal biopsies were taken from patients with inflammatory bowel disease (IBD) (20 with Crohn's disease; 20 with ulcerative colitis) and from 20 controls...
August 10, 2017: Digestive and Liver Disease
Eirini Zacharopoulou, Maria Gazouli, Maria Tzouvala, Antonios Vezakis, George Karamanolis
Inflammatory bowel diseases (IBDs) are multifactorial autoimmune diseases with growing prevalence but the interaction between genetic, environmental and immunologic factors in their development is complex and remains obscure. There is great need to understand their pathogenetic mechanisms and evolve diagnostic and therapeutic tools. Long non-coding RNAs (lncRNAs) are RNA molecules longer than 200 nucleotides that are known to interfere in gene regulation but their roles and functions have not yet been fully understood...
August 9, 2017: Digestive and Liver Disease
Wojciech Marlicz, Karolina Skonieczna-Żydecka, Diana E Yung, Igor Loniewski, Anastasios Koulaouzidis
INTRODUCTION: Microscopic colitis (MC) is a clinical syndrome of severe watery diarrhea with few or no endoscopic abnormalities. The incidence of MC is reported similar to that of other inflammatory bowel diseases. The need for histological confirmation of MC frequently guides reimbursement health policies. With the advent of high-definition (HD) coloscopes, the incidence of reporting distinct endoscopic findings in MC has risen. This has the potential to improve timely diagnosis and cost-effective MC management and diminish the workload and costs of busy modern endoscopy units...
August 9, 2017: Digestive and Liver Disease
Ya-Wei Bi, Dan Wang, Zhao-Shen Li, Liang-Hao Hu
No abstract text is available yet for this article.
August 9, 2017: Digestive and Liver Disease
Theresa Bucsics, Maria Schoder, Nicolas Goeschl, Philipp Schwabl, Mattias Mandorfer, Magdalena Diermayr, Maria Feldner, Florian Riedl, David Bauer, Bernhard Angermayr, Manfred Cejna, Arnulf Ferlitsch, Wolfgang Sieghart, Michael Trauner, Markus Peck-Radosavljevic, Josef Karner, Franz Karnel, Thomas Reiberger
BACKGROUND: Early implantation (<72h) of a transjugular intrahepatic portosystemic shunt (TIPS) after acute variceal bleeding (AVB) improves survival in highly selected patients. METHODS: We retrospectively assessed bleeding control and survival of unselected cirrhotic patients undergoing early TIPS implantation within 72h. We compared the outcomes to patients meeting early TIPS criteria but receiving late TIPS within 3-28days after AVB and endoscopic/medical treatment...
August 8, 2017: Digestive and Liver Disease
Timothée Wallenhorst, Charlène Brochard, Eric Le Balch, Anaïs Bodere, Aurélien Garros, Alexandre Merlini-l'Heritier, Guillaume Bouguen, Laurent Siproudhis
BACKGROUND: The natural history of anal ulcerations in Crohn's disease remains unknown. AIMS: To assess the long-term outcomes of anorectal ulcerations. METHODS: Data from consecutive patients with perineal Crohn's disease were prospectively recorded. The data of patients with anal ulceration were extracted. RESULTS: Anal ulcerations were observed in 154 of 282 patients (54.6%), and 77 cases involved cavitating ulcerations...
August 4, 2017: Digestive and Liver Disease
Muhammad Shariq Usman, Tariq Jamal Siddiqi
No abstract text is available yet for this article.
August 2, 2017: Digestive and Liver Disease
Marco Toscano, Roberta De Grandi, Luca Pastorelli, Maurizio Vecchi, Lorenzo Drago
Probiotics are used all over the world as their beneficial effects on the human organism have been widely demonstrated. Certain probiotics can down-regulate production of pro-inflammatory cytokines and promote intestinal epithelial barrier functions, increasing an anti-inflammatory response and contributing to the host's overall health. The main mechanisms by which probiotic microorganisms can interact with the host are by modulating the immune system and the epithelial cell functions and interacting with intestinal gut microbiota...
August 1, 2017: Digestive and Liver Disease
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