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Digestive and Liver Disease

Shoichi Yoshimizu, Toshiyuki Yoshio, Akiyoshi Ishiyama, Tomohiro Tsuchida, Yusuke Horiuchi, Masami Omae, Toshiaki Hirasawa, Takao Asari, Keisho Chin, Junko Fujisaki
No abstract text is available yet for this article.
August 25, 2018: Digestive and Liver Disease
Felice De Stefano, Eduardo Chacon, Lilia Turcios, Francesc Marti, Roberto Gedaly
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths and the fifth most common cancer worldwide. Most of these patients are seen with advanced disease at the time of presentation. In spite of its high prevalence, there are not many therapeutic options available for patients with advanced-stage HCC. There is an urgent need for improving early detection and prognostication of patients with HCC. In addition, the development of new therapies targeting specific pathways involved in the pathogenesis of HCC should be a major goal for future research, with the objective of improving outcomes of patients with HCC...
August 24, 2018: Digestive and Liver Disease
Zeqi Guo, Miaomiao Li, Bing Han, Xingshun Qi
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases. The relationship of NAFLD with thyroid function parameters and hypothyroidism remains controversial. AIM: To clarify the effect of thyroid function parameters and hypothyroidism on the development of NAFLD and progression to nonalcoholic steatohepatitis (NASH). METHODS: PubMed, EMBASE, and Cochrane library databases were searched. Study quality was assessed...
August 23, 2018: Digestive and Liver Disease
Marco Di Pascoli, Vincenzo La Mura
No abstract text is available yet for this article.
August 23, 2018: Digestive and Liver Disease
Helmut Neumann, Cesare Hassan
No abstract text is available yet for this article.
August 22, 2018: Digestive and Liver Disease
Paola Soriani, Simone Muratori, Michele Varoli, Mauro Manno
No abstract text is available yet for this article.
August 21, 2018: Digestive and Liver Disease
Céline Gregoire, Alexandra Briquet, Caroline Pirenne, Chantal Lechanteur, Edouard Louis, Yves Beguin
No abstract text is available yet for this article.
August 21, 2018: Digestive and Liver Disease
Taija Korpela, Karina Cárdenas-Jaén, Livia Archibugi, Goran Poropat, Patrick Maisonneuve, Paolo Giorgio Arcidiacono, Nicolò De Pretis, Matthias Löhr, Gabriele Capurso, Enrique de-Madaria
BACKGROUND: Acute pancreatitis (AP) is the most common complication after endoscopic retrograde cholangiopancreatography (ERCP). Statins have been traditionally associated to an increased risk of AP, however, recent evidence suggests that statins may have a protective role against this disease. AIMS: Our primary aim is to investigate whether the use of statins has a protective effect against post-ERCP pancreatitis (PEP). Secondary outcomes are: to evaluate the effect of other drugs on the incidence of PEP; to ascertain the relationship between the use of statins and the severity of PEP; and to evaluate the effect of other risk and protective factors on the incidence of PEP...
August 20, 2018: Digestive and Liver Disease
Aline Barhli, Jérôme Cros, Laurent Bartholin, Cindy Neuzillet
Pancreatic ductal adenocarcinoma (PDAC) is the digestive cancer with the poorest prognosis, with a 5-year overall survival rate of 7%. Complete surgical resection followed by adjuvant chemotherapy is the only treatment with curative intent. However, many patients with an apparently localized disease who may undergo primary tumor resection already have micro-metastatic disease and will promptly develop metastases. Considering the significant rate of morbidity and mortality upon pancreatic surgery, the pre-operative identification of patients with an aggressive disease is therefore a major clinical issue...
August 20, 2018: Digestive and Liver Disease
Anna Chiara Piscaglia, Loris Riccardo Lopetuso, Lucrezia Laterza, Viviana Gerardi, Elena Sacchini, Emanuele Leoncini, Stefania Boccia, Maria Loredana Stefanelli, Antonio Gasbarrini, Alessandro Armuzzi
BACKGROUND: The burden of Crohn's disease (CD) and ulcerative colitis (UC) has never been estimated in the Republic of San Marino, the third smallest nation of the world. AIMS: To assess the occurrence and clinical features of CD and UC in San Marino during the last 35 years. METHODS: We retrospectively evaluated the prevalence, incidence, and main clinical aspects of CD and UC from 1980 to 2014, crossing data from various sources. RESULTS: Prevalence rates (per 100,000) on December 31, were 241 for CD (263 in males and 220 in females) and 311 for UC (370 in males and 255 in females)...
August 20, 2018: Digestive and Liver Disease
Cindy Neuzillet, Sébastien Gaujoux, Nicolas Williet, Jean-Baptiste Bachet, Lucile Bauguion, Laurianne Colson Durand, Thierry Conroy, Laetitia Dahan, Marine Gilabert, Florence Huguet, Lysiane Marthey, Julie Meilleroux, Louis de Mestier, Bertrand Napoléon, Fabienne Portales, Antonio Sa Cunha, Lilian Schwarz, Julien Taieb, Benoist Chibaudel, Olivier Bouché, Pascal Hammel
BACKGROUND: This document is a summary of the French intergroup guidelines regarding the management of pancreatic adenocarcinoma (PA), updated in July 2018. DESIGN: This collaborative work was produced under the auspices of all French medical and surgical societies involved in the management of PA. It is based on the previous guidelines, recent literature review and expert opinions. Recommendations were graded in three categories, according to the level of evidence...
August 18, 2018: Digestive and Liver Disease
Silvia Cucchiarelli, Francesco Santopaolo, Antonietta Lamazza, Raffaella Lionetti, Ilaria Lenci, Tommaso Maria Manzia, Mario Angelico, Martina Milana, Leonardo Baiocchi
BACKGROUND: Upper endoscopy is the main tool for the accurate assessment of the risk of bleeding in cirrhotic patients. AIM: To evaluate the diagnostic accuracy of upper endoscopy, in cirrhotic subjects, during common clinical practice. METHODS: 120 endoscopic reports produced in different hospitals in our region were retrospectively and randomly selected. After a general evaluation, aimed at assessing the description of various endoscopic features, reports were evaluated by four expert endoscopists and four expert hepatologists...
August 18, 2018: Digestive and Liver Disease
Clémentine Gandilhon, Patricia Soler-Michel, Léa Vecchiato, Claude Chaunier, Isabelle Fay, Thomas Walter, Jérôme Rivory, Jean-Christophe Saurin, Thierry Ponchon, Mathieu Pioche
BACKGROUND: A large proportion of individuals with a positive faecal immunologic test (FIT) will never undergo the recommended colonoscopy despite a full sequence of reminders. AIMS: This prospective study aimed to recruit refractory individuals by a motivational personalised phone call given by a screening physician. METHODS: We evaluated the impact of a motivational phone call given by a physician of the screening organisation in order to convince patients with positive FIT to undergo a colonoscopy...
August 17, 2018: Digestive and Liver Disease
Maria Lia Scribano, Claudio Papi, Francesco Costa, Aurora Bortoli, Francesco Bortoluzzi, Elisabetta Buscarini, Maria Cappello, Luigi Caserta, Claudio Cortelezzi, Antonio Ferronato, Francesco Manguso, Silvia Mazzuoli, Nicoletta Orzes, Anna Kohn
BACKGROUND: No data are available on the variability in the clinical management of ulcerative colitis (UC) patients by Italian gastroenterologists. Therefore, improving the standards of UC care as provided by the National Welfare Clinical Path (PDTA), in accordance with the European Crohn's and Colitis Organization (ECCO) guidelines for UC, is not easy. AIMS: To assess the management of UC by Italian gastroenterologists in a real-life setting taking into account its variability...
August 16, 2018: Digestive and Liver Disease
Maria Guarino, Luca Viganò, Francesca Romana Ponziani, Edoardo Giovanni Giannini, Quirino Lai, Filomena Morisco
Although studies suggest decreased incident hepatocellular carcinoma (HCC) after treatment with direct-acting antivirals (DAAs) for hepatitis C virus (HCV) infection, data are conflicting regarding risk and aggressiveness of recurrence in patients who have a history of treated HCC. This review analyses data available in literature in order to elucidate the impact of DAAs on the risk of HCC recurrence after successful treatment of the tumor. Overall 24 papers were identified. The available data cannot be considered definitive, but the initial alarmist data indicating an increased risk of recurrence have not been confirmed by most subsequent studies...
August 11, 2018: Digestive and Liver Disease
Luca Barresi, Matteo Tacelli, Dario Ligresti, Mario Traina, Ilaria Tarantino
Despite the progress achieved by scientific research in recent years, pancreatic cystic lesions (PCLs) remain a challenging clinical problem. A significant percentage of benign PCLs are still wrongly sent to surgery, with all the related risks of a high number of surgery-related complications and mortality. Diagnosis of the type of PCL, and risk stratification for malignancy are essential for a correct management of these lesions. Several guidelines have identified some clinical and morphological aspects suggesting the need for more accurate exams...
August 11, 2018: Digestive and Liver Disease
Uri Kopylov, Irit Avni-Biron, Yulia Ron, Benjamin Koslowsky, Matti Waterman, Saleh Daher, Bella Ungar, Doron Schwartz, Eran Zittan, Michal Openhaim, Henit Yanai, Nitsan Maharshak, Ariella Bar Gil Shitrit, Timna Naftali, Rami Eliakim, Yehuda Chowers, Shomron Ben-Horin, Iris Dotan
INTRODUCTION: Several real-world experience (RWE) studies with vedolizumab (VDZ) for induction of remission in inflammatory bowel diseases (IBD) have been published; however, long-term RWE data is scarce. AIMS: To describe the effectiveness and safety of VDZ in maintenance treatment of IBD. METHODS: A multicenter retrospective national study. The primary outcome of was clinical response at week 52; main secondary aims included clinical remission at week 52, rates of secondary loss of response and treatment discontinuation...
August 10, 2018: Digestive and Liver Disease
Véronique Vendrely, Vincent Launay, Haythem Najah, Denis Smith, Denis Collet, Caroline Gronnier
The overall prognosis of patients with esophageal cancer has improved in recent decades due to surgical and medical progress, but overall survival remains poor. Better patient selection and tailored treatment are needed. Different prognostic factors linked with the patient, tumoral characteristics and treatment with curative intent have been identified and are the purpose of this review. Tumor detection at an earlier stage, the advent of new molecules and therapeutic combinations, and the centralization of management in high-volume centers should help to improve the prognosis of esophageal cancer...
August 9, 2018: Digestive and Liver Disease
Juliana M Costa, Filipa Costeira, Filipa Vieira, João B Soares
No abstract text is available yet for this article.
August 8, 2018: Digestive and Liver Disease
Cristiano Spada, Cesare Hassan, Guido Costamagna
No abstract text is available yet for this article.
August 7, 2018: Digestive and Liver Disease
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