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Digestive and Liver Disease

Judit Vidal-González, Macarena Simón-Talero, Joan Genescà
No abstract text is available yet for this article.
June 28, 2018: Digestive and Liver Disease
Astrid Lièvre, Jean-Louis Merlin, Jean-Christophe Sabourin, Pascal Artru, Pierre Laurent-Puig, Michel Ducreux
No abstract text is available yet for this article.
June 28, 2018: Digestive and Liver Disease
Entcho Klenske, Markus F Neurath, Raja Atreya, Timo Rath
With the rapid expansion and diversification of the repertoire of biological agents utilized in inflammatory bowel diseases and cancer and the increase in oncological patients in gastroenterology, visualization of single receptor or molecular target expression and the subsequent initiation of expression tailored therapy are gaining increasing attention. Through the combination of utilizing fluorescently labeled probes with high specificity towards defined molecular targets and their subsequent detection and visualization with endoscopic devices, molecular imaging is a new emerging field focusing on the receptor expression within the mucosa on a cellular level rather than on macroscopic changes...
June 23, 2018: Digestive and Liver Disease
Yuichi Yamaga, Akihisa Fukuda, Yuki Nakanishi, Norihiro Goto, Yoshihide Matsumoto, Takuto Yoshioka, Takahisa Maruno, Tsutomu Chiba, Hiroshi Seno
BACKGROUND: Accumulating evidence has shown the existence of tumor stem cells with therapeutic potential. Previously, we reported that doublecortin like kinase 1 (Dclk1) marks tumor stem cells but not normal stem cells in the intestine of ApcMin/+ mice, and that Dclk1- and Lgr5-double positive tumor cells are the tumor stem cells of intestinal tumors. AIM: To investigate molecules highly expressed in the Dclk1+ normal intestinal and Dclk1+ tumor cells in ApcMin/+ mice...
June 22, 2018: Digestive and Liver Disease
Pei Hu, Changzheng Ke, Xingrong Guo, Pan Ren, Yaoyao Tong, Sen Luo, Yulin He, Zhiqiang Wei, Bin Cheng, Ruiming Li, Jie Luo, Zhongji Meng
AIM: The aim of this study is to investigate the role of glypican-3(GPC3)/wnt/β-catenin signaling pathway and autophagy in the regulation of hepatocellular carcinoma (HCC) growth mediated by curcumin. METHODS: HepG2 cells were treated with various concentrations of curcumin and/or GPC3-targeting siRNA in the presence or absence of 3-MA. Cell proliferation and apoptosis were determined by MTT and TUNEL assay, respectively. Expression of GPC3, β-catenin, c-myc, LC3, and Beclin1 was determined by western blotting...
June 21, 2018: Digestive and Liver Disease
Lorenzo Loffredo, Francesco Violi
BACKGROUND: Treatment of thrombocytopenia with thrombopoietin receptor agonists (TPORAs) seems to be associated with portal vein thrombosis (PVT) in patients with chronic liver disease (CLD). We performed a meta-analysis of the trials carried out in this clinical setting to assess if such association is detectable. METHODS: We performed a meta-analysis with studies that compared the effect of TPORAS vs placebo in patients with CLD and thrombocytopenia. RESULTS: Four studies, including 1953 patients, reported the incidence of PVT in patients with CLD and thrombocytopenia treated with TPORAs or placebo...
June 20, 2018: Digestive and Liver Disease
José Ignacio Fortea, Ángela Puente, Iranzu Ezcurra, Antonio Cuadrado, María Teresa Arias-Loste, Joaquín Cabezas, Susana Llerena, Paula Iruzubieta, Carlos Rodríguez-Lope, Patricia Huelin, Fernando Casafont, Emilio Fábrega, Javier Crespo
BACKGROUND: Knowledge of haematological abnormalities in cirrhosis has greatly improved in recent years. AIMS: To evaluate how Spanish Digestive Disease specialists manage haemostatic alterations and associated disorders in patients with cirrhosis. METHODS: All members of the Spanish Association for the Study of the Liver and Spanish Society of Digestive Pathology were invited to fill in a web-based questionnaire. RESULTS: 135 professionals, 93 hepatologists and 42 non-hepatologists responded to the survey...
June 12, 2018: Digestive and Liver Disease
Lucia Craxì, Vito Di Marco
No abstract text is available yet for this article.
June 11, 2018: Digestive and Liver Disease
Giovanni Marchegiani, Stefano Andrianello, Giampaolo Perri, Tommaso Pollini, Andrea Caravati, Erica Secchettin, Giuseppe Malleo, Claudio Bassi, Roberto Salvia
BACKGROUND: Current guidelines do not address the role of age in the management of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas. AIM: To evaluate whether clinical features and risk for malignancy are affected by patient's age at diagnosis. METHODS: In total, 2189 IPMNs, both surgically resected or surveilled, were dichotomized according to a 50-year-old cutoff and compared in terms of pathological features, cumulative risk of developing high-risk stigmata (HRS), overall survival (OS) and disease-specific survival (DSS)...
June 11, 2018: Digestive and Liver Disease
Amy Tyberg, Ming-Ming Xu, Monica Gaidhane, Michel Kahaleh
INTRODUCTION: Evaluation of indeterminate biliary strictures remains a diagnostic challenge. Optical coherence tomography (OCT) provides in-vivo, wide-field, cross-sectional imaging at the microstructure level. We present the first preliminary data using a second-generation OCT system using volumetric laser endomicroscopy (VLE) in biliary and pancreatic duct strictures. METHODS: 10 consecutive patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) and OCT for indeterminate biliary or pancreatic stricture evaluation were captured in a registry...
June 8, 2018: Digestive and Liver Disease
Florian M Corvinus, Stefan Heinrich, Helmut Neumann, Edin Hadzijusufovic, Benjamin Babic, Hauke Lang, Peter P Grimminger
INTRODUCTION: Gastroparesis (GP) is defined as delayed gastric emptying (GE) without any obstruction of the pylorus. It can be divided into idiopathic, diabetic, post surgical and rare causes. Electronic gastric stimulation (EGS) - Enterra Medtronic™ - is a part of GP therapy. Although its positive impact has been reported in open label trials, randomized controlled trials failed in demonstrating a positive outcome. The aim of this pilot study was to establish a reliable prediction for permanent gastric stimulation...
June 7, 2018: Digestive and Liver Disease
Aziz Zaanan, Olivier Bouché, Leonor Benhaim, Bruno Buecher, Nicolas Chapelle, Olivier Dubreuil, Nadim Fares, Victoire Granger, Christine Lefort, Johan Gagniere, Julie Meilleroux, Anne-Sophie Baumann, Veronique Vendrely, Michel Ducreux, Pierre Michel
INTRODUCTION: This document is a summary of the French Intergroup guidelines regarding the management of gastric cancer published in October 2016, available on the website of the French Society of Gastroenterology (SNFGE) (, updated in October 2017. METHODS: This collaborative work was realized under the auspices of several French medical societies involved in management of gastric cancer. Recommendations are graded in three categories (A-C), according to the amount of evidence found in the literature until July 2017...
June 6, 2018: Digestive and Liver Disease
Chuangye He, Yong Lv, Zhengyu Wang, Wengang Guo, Jun Tie, Kai Li, Jing Niu, Luo Zuo, Tianlei Yu, Xulong Yuan, Hui Chen, Qiuhe Wang, Haibo Liu, Wei Bai, Enxing Wang, Dongdong Xia, Bohan Luo, Xiaomei Li, Jie Yuan, Na Han, Ying Zhu, Jianhong Wang, Zhanxin Yin, Daiming Fan, Guohong Han
BACKGROUND: Whether pre-existing nonvariceal spontaneous portosystemic shunts (SPSSs) in cirrhotic patients affect outcomes after transjugular intrahepatic portosystemic shunt (TIPS) and whether they need to be closed remains unclear. AIM: To assess the effects of the presence or embolization of SPSSs on outcomes after TIPS for cirrhosis. METHODS: From January 2004 to December 2014, 903 consecutive cirrhotic patients who underwent TIPS in a tertiary-care center were included, of which 715 patients had no SPSS (N-SPSS group), 144 patients had an SPSS without embolization (SPSS group), and 44 had an SPSS with embolization (SPSS + E group)...
June 5, 2018: Digestive and Liver Disease
Gianluca Cuomo, Margherita Digaetano, Marianna Menozzi, Sara Tagliazucchi, Giovanni Guaraldi, Vanni Borghi, Cristina Mussini
BACKGROUND: Men who had sex with men (MSM) living with HIV are at higher risk of developing sexual transmitted diseases. This study reports two years incidence rate and prevalence of HCV in a cohort of HIV positive MSM. METHODS: MSM HIV-positive outpatients negative to HCV-Ab at first observation entered a Kaplan-Meier model in order to assess the HCV infection incidence rate. Prevalence analysis was performed with MSM HIV-positive that were on follow-up at 2016...
June 5, 2018: Digestive and Liver Disease
Jonel Trebicka
No abstract text is available yet for this article.
June 4, 2018: Digestive and Liver Disease
Zi-Ye Zhao, Yu-Liang Jiang, Bai-Rong Li, En-Da Yu, Shou-Bin Ning
No abstract text is available yet for this article.
June 4, 2018: Digestive and Liver Disease
Paula Mosińska, Adrian Szczepaniak, Jakub Fichna
Functional gastrointestinal disorders (FGIDs), such as irritable bowel syndrome (IBS) and chronic constipation (CC), are commonly diagnosed conditions in clinical practice which create a substantial global burden. Since the farnesoid X receptor (FXR) and bile acids (BAs) are responsible for maintaining homeostasis in the GI tract, any disturbances in the expression of FXR or the composition of BAs may contribute to the development of the GI symptoms. Alterations in the mechanism of action of FXR directly affect the BAs pool and account for increased intestinal permeability and changes in abundance and diversity of gut microbiota leading to intestinal dysmotility...
May 30, 2018: Digestive and Liver Disease
Abhijeet Yadav, Satya Kurada, Joshua Foromera, Kenneth R Falchuk, Joseph D Feuerstein
BACKGROUND: Long-term inflammatory complications of IPAA include Crohn's Disease (CD) or "CD-like" (CDL) condition. We performed a meta-analysis to evaluate the efficacy of anti-tumor necrosis factor (anti-TNF) with or without immunomodulator (IM) therapy in this group of patients. METHODS: Literature databases were searched from inception to October 4, 2017. Further searches using references from papers of interest were conducted and, abstracts from major GI conferences were searched...
May 30, 2018: Digestive and Liver Disease
Vincent Zimmer
No abstract text is available yet for this article.
May 30, 2018: Digestive and Liver Disease
Shalimar, Gyanranjan Rout, Shekhar S Jadaun, Gyan Ranjan, Saurabh Kedia, Deepak Gunjan, Baibaswata Nayak, Subrat Kumar Acharya, Ajay Kumar, Arti Kapil
BACKGROUND: Acute on chronic liver failure (ACLF) is associated with high short term mortality. We aimed to evaluate the prevalence, predictors and impact of bacterial infection in ACLF. METHODS: Consecutive hospitalized patients with cirrhosis and acute decompensation (AD), from January 2011-March 2017, were included. Predictors of survival and infection were assessed. RESULTS: 572 patients with cirrhosis and AD were classified into 3 groups - no infection (group 1, n = 190, 33...
May 28, 2018: Digestive and Liver Disease
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