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Digestive and Liver Disease

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https://www.readbyqxmd.com/read/28807489/a-model-to-estimate-survival-in-ambulatory-patients-with-hepatocellular-carcinoma-can-it-predict-the-natural-course-of-hepatocellular-carcinoma
#1
Won-Mook Choi, Su Jong Yu, Hongkeun Ahn, Hyeki Cho, Young Youn Cho, Minjong Lee, Jeong-Ju Yoo, Yuri Cho, Dong Hyeon Lee, Eun Ju Cho, Jeong-Hoon Lee, Yoon Jun Kim, Jung-Hwan Yoon
BACKGROUND: Several hepatocellular carcinoma (HCC) staging systems are available including the newly developed staging system, the Model to Estimate Survival in Ambulatory HCC patients (MESIAH); however, whether these staging systems could predict the natural course of HCC is largely unknown. METHODS: 1013 patients with history of HCC treatment and 111 patients without any history of treatment till death or last follow-up at a single tertiary hospital were included...
July 29, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28807490/fabp1-and-hepar-expression-levels-in-barrett-s-oesophagus-and-associated-neoplasia-in-an-asian-population
#2
Supriya Srivastava, Florian Kern, Neel Sharma, Frank McKeon, Wa Xian, Khay Guan Yeoh, Khek Yu Ho, Ming Teh
INTRODUCTION: Barrett's oesophagus (BE) is a premalignant condition associated with oesophageal adenocarcinoma (EAC). Evidence highlights that EAC is associated with an estimated 5-year survival of approximately 10-15%. Therefore, there is a need to determine which biomarkers are of value in the diagnosis of BE and beyond. The aim of our study was to evaluate the clinical significance of markers known to be expressed across BE and associated neoplasia. METHODS: Retrospective tissues were obtained from columnar lined oesophagus (CLE) without goblet cells (n=22), BE (n=29), dysplasia (n=14), and EAC (n=10)...
July 27, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28801181/the-use-of-oral-corticosteroids-in-inflammatory-bowel-diseases-in-italy-an-ig-ibd-survey
#3
Federica Fascì-Spurio, Gianmichele Meucci, Claudio Papi, Simone Saibeni
AIM: To evaluate how Italian gastroenterologists use corticosteroids in clinical practice for the treatment of Crohn's disease (CD) and ulcerative colitis (UC). MATERIAL AND METHODS: All members of the Italian Group for Inflammatory Bowel Disease (IG-IBD) were invited to fill in a web-based questionnaire. RESULTS: 131/448 (29.2%) members completed the survey. In mild-to-moderate UC and CD relapses, low-bioavailability steroids (LBS) are first-line therapy for 37% and 42% of clinicians, respectively...
July 22, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28801180/obesity-as-predictor-of-postoperative-outcomes-in-liver-transplant-candidates-review-of-the-literature-and-future-perspectives
#4
REVIEW
Michele Barone, Maria Teresa Viggiani, Alfonso W Avolio, Andrea Iannone, Maria Rendina, Alfredo Di Leo
BACKGROUND: Current American and European guidelines consider a pre-transplant BMI ≥40kg/m(2) as a relative contraindication for liver transplantation but this recommendation is graded as uncertain and requires further research. Moreover, conflicting results are reported on the predictive value of BMI 30-39.9kg/m(2) on post-transplant complication and mortality risk. AIM: This study analyzed the data of the literature on the effect of all three BMI classes of obesity on postoperative outcomes in liver transplantation...
July 22, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28801179/family-history-of-gastric-cancer-is-associated-with-the-risk-of-colorectal-neoplasia-in-korean-population
#5
Yoon Suk Jung, Nam Hee Kim, Hyo-Joon Yang, Soo-Kyung Park, Jung Ho Park, Dong Il Park, Chong Il Sohn
BACKGROUND: Family history of cancers at different sites except for colorectum has not been evaluated as a risk factor for colorectal neoplasia (CRN). AIMS: To investigate CRN risk according to family history of cancers at 12 different sites, including stomach and colorectum. METHODS: A cross-sectional study was performed on 139,497 asymptomatic Koreans who underwent colonoscopy as part of a health check-up. RESULTS: The mean age of the study population was 41...
July 22, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28780052/validation-of-whole-slide-imaging-in-the-primary-diagnosis-of-liver-biopsies-in-a-university-hospital
#6
Adela Saco, Alba Diaz, Monica Hernandez, Daniel Martinez, Carla Montironi, Paola Castillo, Natalia Rakislova, Marta Del Pino, Antonio Martinez, Jaume Ordi
BACKGROUND: Experience in the use of whole slide imaging (WSI) for primary diagnosis is limited and there are no comprehensive reports evaluating this technology in liver biopsy specimens. AIMS: To determine the accuracy of interpretation of WSI compared with conventional light microscopy (CLM) in the diagnosis of needle liver biopsies. METHODS: Two experienced liver pathologists blindly analyzed 176 consecutive biopsies from the Pathology Department at the Hospital Clinic of Barcelona...
July 19, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28756974/incidence-of-and-risk-factors-for-pancreatic-cancer-in-chronic-pancreatitis-a-cohort-of-1656-patients
#7
Lu Hao, Xiang-Peng Zeng, Lei Xin, Dan Wang, Jun Pan, Ya-Wei Bi, Jun-Tao Ji, Ting-Ting Du, Jin-Huan Lin, Di Zhang, Bo Ye, Wen-Bin Zou, Hui Chen, Ting Xie, Bai-Rong Li, Zhao-Hong Zheng, Teng Wang, Hong-Lei Guo, Zhuan Liao, Zhao-Shen Li, Liang-Hao Hu
BACKGROUND: Risk of pancreatic cancer may increase in chronic pancreatitis patients. AIMS: This study aimed to identify the incidence of and risk factors for pancreatic cancer in chronic pancreatitis patients. METHODS: Chronic pancreatitis patients admitted to our center from January 2000 to December 2013 were enrolled. Cumulative rates of pancreatic cancer and survival rates were calculated. The standardized incidence ratio was calculated based on the pancreatic cancer incidence in general population of China...
July 15, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28778820/therapy-experiences-and-preferences-among-patients-with-anemia-results-of-a-cross-sectional-survey-among-italian-patients-with-inflammatory-bowel-disease
#8
Sonja Milovanovic, Franco Scaldaferri, Stefania Canarecci, Flavia Kheiraoui, Giulia Ciancarella, Chiara de Waure, Agnese Collamati, Elisa Schiavoni, Antonio Gasbarrini, Stefania Boccia, Andrea Poscia
BACKGROUND: Anemia represents one of the most common and often the least treated complications of inflammatory bowel disease (IBD). AIMS: Our study investigates experiences and preferences concerning anemia treatment in patients with IBD. METHODS: IBD patients previously diagnosed with anemia were invited to participate in an anonymous survey between July and September 2015, which assessed demographic and clinical data, and experiences regarding anemia treatment...
July 5, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28780053/association-between-f508-deletion-in-cftr-and-chronic-pancreatitis-risk
#9
REVIEW
Dong Zhao, Yanzhen Xu, Jiatong Li, Shien Fu, Feifan Xiao, Xiaowei Song, Zhibin Xie, Min Jiang, Yan He, Chengwu Liu, Qiongxian Wen, Xiaoli Yang
BACKGROUND: The cystic fibrosis transmembrane conductance regulator (CFTR) has been reported to influence individual susceptibility to chronic pancreatitis (CP), but the results of previous studies are controversial. AIMS: We performed a study to demonstrate the relationship between CFTR and CP. METHODS: We searched PubMed, Scopus, and Embase for studies of patients with CP. Seven studies from 1995 to 2016 were identified, and included 64,832 patients...
July 1, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28734776/a-preoperative-score-to-predict-early-death-after-pancreatic-cancer-resection
#10
Gianpaolo Balzano, Erica Dugnani, Stefano Crippa, Marina Scavini, Valentina Pasquale, Francesca Aleotti, Daniela Liberati, Alessandra Gandolfi, Giulio Belfiori, Michele Reni, Claudio Doglioni, Giacomo Ruffo, Cristina Marmorale, Massimo Falconi, Lorenzo Piemonti
BACKGROUND: This study aimed to develop and validate a preoperative prognostic model for death within one year post-surgery in patients with resectable pancreatic ductal adenocarcinoma (PDAC). METHODS: A derivation cohort study of 296 patients who underwent surgical resection of PDAC was prospectively enrolled in an observational study. Preoperative predictors of one year mortality were used to develop a risk score which was then validated in an external cohort of 182 patients with resectable PDAC...
July 1, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28676419/portal-vein-stenting-for-portal-vein-stenosis-caused-by-bile-duct-cancer
#11
Ken Kamata, Mamoru Takenaka, Masakatsu Tsurusaki, Masatoshi Kudo
No abstract text is available yet for this article.
July 1, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28733177/transjugular-local-thrombolysis-with-without-tips-in-patients-with-acute-non-cirrhotic-non-malignant-portal-vein-thrombosis
#12
Christoph Klinger, Bettina Riecken, Arthur Schmidt, Andrea De Gottardi, Benjamin Meier, Jaime Bosch, Karel Caca
BACKGROUND & AIMS: Therapeutic anticoagulation is the standard treatment in patients with acute non-cirrhotic portal vein thrombosis (PVT). In critically ill patients, anticoagulation only may not suffice to achive rapid and stable recanalization. This study evaluates efficacy and safety of transjugular interventional therapy in acute non-cirrhotic PVT. METHODS: This retrospective study includes 17 consecutive patients with acute noncirrhotic, non-malignant PVT...
June 27, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28729141/effects-of-transjugular-intrahepatic-portosystemic-shunt-tips-on-blood-volume-distribution-in-patients-with-cirrhosis
#13
Troels M Busk, Flemming Bendtsen, Jens H Henriksen, Stefan Fuglsang, Jens O Clemmesen, Fin S Larsen, Søren Møller
BACKGROUND: Cirrhosis is accompanied by portal hypertension with splanchnic and systemic arterial vasodilation, and central hypovolaemia. A transjugular intrahepatic portosystemic shunt (TIPS) alleviates portal hypertension, but also causes major haemodynamic changes. AIMS: To investigate effects of TIPS on regional blood volume distribution, and systemic haemodynamics. METHODS: Thirteen cirrhotic patients had their regional blood volume distribution determined with gamma-camera technique before and after TIPS...
June 27, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28688880/igg3-subclass-a-possible-trigger-of-mixed-cryoglobulin-cascade-in-hepatitis-c-virus-chronic-infection
#14
Umberto Basile, Francesca Gulli, Laura Gragnani, Elisa Fognani, Cecilia Napodano, Krizia Pocino, Anna Linda Zignego, Gian Ludovico Rapaccini
HCV is a hepatotropic and lymphotropic virus and is the most frequent cause of "benign" mono-oligoclonal B-lymphocyte proliferation, observed in mixed cryoglobulinemia (MC). The study aims to investigate the presence, prevalence and characteristics of the subclasses of cryoglobulins in HCV-patients to look for a relationship with MC. Fifty HCV-infected patients with cryoglobulins were enrolled. IgG subclasses were characterized in cryoprecipitate, and serum IgG and IgM Rheumatoid Factor (RF) were determined...
June 24, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28750872/a-new-index-predicts-early-allograft-dysfunction-following-living-donor-liver-transplantation-a-propensity-score-analysis
#15
Jiu-Lin Song, Jian Yang, Lu-Nan Yan, Jia-Yin Yang, Tian-Fu Wen, Bo Li, Yong Zeng, Hong Wu, Wen-Tao Wang, Ming-Qing Xu, Zhe-Yu Chen, Yong-Gang Wei, Li Jiang
OBJECTIVE/AIM: The aim of this study was to identify a new index to predict early allograft dysfunction following living donor liver transplantation. METHODS: The study enrolled 260 adult living donor liver transplantation recipients. Postoperative laboratory variables were assessed for their association with the prevalence of early allograft dysfunction using the inverse probability of treatment weighting and propensity-score matching (n=93 pairs) analysis. RESULTS: Forty-seven recipients (18...
June 23, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28734775/type-ii-iii-ercp-related-perforations-treated-with-temporary-fully-covered-self-expandable-stents
#16
LETTER
Al Tringali, Marcello Cintolo, Cesare Hassan, Douglas G Adler, Massimiliano Mutignani
No abstract text is available yet for this article.
June 23, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28733179/nurse-in-patients-health-status-assessment-data-from-a-pilot-study-assessing-agreement-among-nurse-and-gastroenterologist-in-computing-ibd-clinical-scores
#17
Filippo Mocciaro, Giulia Maria Pecoraro, Roberto Di Mitri, Daniela Scimeca, Fabrizio Bossa, Giuseppina Russo, Giuseppina Martino, Vincenzo Costanza, Maria Antonella Profita, Concetta Orlando, Gianfranco Profeta, Fabio Tinè
INTRODUCTION: Crohn's Disease (CD) and Ulcerative Colitis (UC) are chronic, systemic Inflammatory Bowel Diseases (IBDs) that need a multidisciplinary approach involving not only different medical specialists but also qualified nurses. AIM: We evaluated the concordance between IBD-nurse and physician in computing Clinical Activity Scores in IBD-patients treated with biologics. METHODS: We enrolled all consecutive IBD-patients treated with biologics in two referral centers for IBD-care...
June 23, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28733178/clinical-usefulness-of-serum-antibodies-as-biomarkers-of-gastrointestinal-and-liver-diseases
#18
REVIEW
Antonio Di Sabatino, Federico Biagi, Marco Lenzi, Luca Frulloni, Marco Vincenzo Lenti, Paolo Giuffrida, Gino Roberto Corazza
The progressively growing knowledge of the pathophysiology of a number of immune-mediated gastrointestinal and liver disorders, including autoimmune atrophic gastritis, coeliac disease, autoimmune enteropathy, inflammatory bowel disease, autoimmune hepatitis, primary sclerosing cholangitis, primary biliary cholangitis and autoimmune pancreatitis, together with the improvement of their detection methods have increased the diagnostic power of serum antibodies. In some cases - coeliac disease and autoimmune atrophic gastritis - they have radically changed gastroenterologists' diagnostic ability, while in others - autoimmune hepatitis, inflammatory bowel disease and autoimmune pancreatitis - their diagnostic performance is still inadequate...
June 23, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28733176/a-case-of-surgical-delayed-sovranastomotic-perforation-successfully-treated-with-an-over-the-scope-clip-with-video
#19
B Mangiavillano, M Bianchetti, L H Eusebi, A Repici
No abstract text is available yet for this article.
June 23, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28712860/tolerance-and-outcomes-of-sorafenib-in-elderly-patients-treated-for-advanced-hepatocellular-carcinoma
#20
Nicolas Williet, Léa Clavel, Aurélie Bourmaud, Céline Verot, Nadia Bouarioua, Xavier Roblin, Philippe Merle, Jean-Marc Phelip
INTRODUCTION: Use of sorafenib remains debated in elderly patients treated for advanced hepatocellular carcinoma (HCC). METHODS: This was a bicentric retrospective study including all patients ≥75years and treated with sorafenib for advanced HCC between January 2010 and March 2014. RESULTS: Of the 51 patients included (median age: 78 years, range: 75-92; performance status (PS) 0-1: 98%; cirrhosis: 88.2%; Child-Pugh A: 95.6%) all experienced at least one adverse event (AE)...
June 23, 2017: Digestive and Liver Disease
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