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Veterinary Anaesthesia and Analgesia

Morgan L Murphy, David S Hodgson, Nora M Bello
OBJECTIVE: To determine the accuracy and precision of flowmeters used for oxygen therapy in a veterinary teaching hospital. STUDY DESIGN: An observational study. METHODS: A total of 50 flowmeters used for oxygen therapy were evaluated using Defender 530 gas flow analyzers to measure flow. For each flowmeter, a minimum of seven flow settings were tested in random order and in triplicate. Flow measured at ambient conditions was converted to standardized flow specifications (21...
November 7, 2017: Veterinary Anaesthesia and Analgesia
Chi Won Shin, Won-Gyun Son, Min Jang, Hyunseok Kim, Hyungjoo Han, Jeesoo Cha, Inhyung Lee
OBJECTIVE: To determine the optimal endotracheal tube size in Beagle dogs using thoracic radiography. STUDY DESIGN: Prospective, randomized, crossover experimental study. ANIMALS: A total of eight healthy adult Beagle dogs. METHODS: Lateral thoracic radiographs were used to measure the internal tracheal diameter at the thoracic inlet. This measurement was multiplied by 60, 70 and 80% to determine the outer diameter of the endotracheal tube for each dog...
November 7, 2017: Veterinary Anaesthesia and Analgesia
Constanza S Meneses, Heine Y Müller, Daniel E Herzberg, Benjamin Uberti, Marianne P Werner, Hedie A Bustamante
OBJECTIVE: To determine the microglial and astrocyte response to painful lameness in horses. STUDY DESIGN: Ionized calcium binding adaptor molecule 1 (Iba-1) and glial fibrillary acidic protein (GFAP) expression, cell density and morphology were determined through immunofluorescence within the dorsal horn of equine spinal cord. ANIMALS: A total of five adult horses with acute or chronic unilateral lameness, previously scheduled for euthanasia...
November 2, 2017: Veterinary Anaesthesia and Analgesia
Yusuke Endo, Koudai Kawase, Taku Miyasho, Tadashi Sano, Kazuto Yamashita, William W Muir
OBJECTIVE: To examine the accuracy of plethysmography variability index (PVI) as a noninvasive indicator of fluid responsiveness in hypovolaemic dogs. STUDY DESIGN: Prospective experimental study. ANIMALS: Six adult healthy sevoflurane-anaesthetized Beagle dogs. METHODS: Dogs were anaesthetized with 1.3-fold their individual minimum alveolar concentration of sevoflurane. The lungs were mechanically ventilated after neuromuscular blockade with vecuronium bromide...
November 2017: Veterinary Anaesthesia and Analgesia
Christopher K Smith, Reza Seddighi, Sherry K Cox, Xiaocun Sun, Heather K Knych, Thomas J Doherty
OBJECTIVE: To determine the effect of dexmedetomidine on induction dose and minimum infusion rate of propofol preventing movement (MIRNM). STUDY DESIGN: Randomized crossover, unmasked, experimental design. ANIMALS: Three male and three female healthy Beagle dogs weighing 10.2 ± 2.8 kg. METHODS: Dogs were studied on three occasions at weekly intervals. Premedications were 0.9% saline (treatment P) or dexmedetomidine (1 μg kg-1, treatment PLD; 2 μg kg-1, treatment PHD) intravenously...
November 2017: Veterinary Anaesthesia and Analgesia
Xavier Moll, Adria Aguilar, Felix García, Rosa Ferrer, Anna Andaluz
OBJECTIVE: To assess the validity and reliability of Doppler ultrasonography (DOP) as compared with invasive arterial blood pressure measurements in anaesthetized dogs weighing less than 5 kg. STUDY DESIGN: Controlled, prospective, clinical study. ANIMALS: A total of 41 privately owned dogs weighing less than 5 kg. METHODS: The dogs were anaesthetized, and an intra-arterial catheter was placed aseptically in the dorsal pedal artery of the pelvic limb to perform invasive blood pressure (IBP) measurement...
September 15, 2017: Veterinary Anaesthesia and Analgesia
Bernardo Baldisserotto, Thaylise V Parodi, E Don Stevens
OBJECTIVE: To test the postexposure analgesic efficacy of low doses of eugenol in zebrafish. STUDY DESIGN: Prospective experimental study. ANIMALS: A total of 76 large adult zebrafish (Danio rerio). METHODS: Fish swimming behavior (median velocity, freeze time, high-speed swimming and distance moved in the vertical direction) was recorded in a 1.6 L video arena before and after exposure to eugenol (0, 1, 2, 5, 10 and 20 mg L-1)...
September 15, 2017: Veterinary Anaesthesia and Analgesia
Viviane H Gomes, Renato Ls Oliveira, Juliana Lr Marques, Cassia Mm Coelho, Marta Fa Silva
OBJECTIVE: To compare sedation and effects on heart rate (HR), mean arterial pressure (MAP) and respiratory rate (fR) of nalbuphine and butorphanol, alone or combined with acepromazine in dogs. STUDY DESIGN: Prospective, randomized experimental trial. ANIMALS: Eight healthy Beagle dogs, aged (mean ± standard deviation) 3.4 ± 0.5 years and weighing 11.0 ± 1.3 kg. METHODS: Each dog was treated four times: physiological saline (1 mL) combined with nalbuphine (0...
September 15, 2017: Veterinary Anaesthesia and Analgesia
Alexandre Gagnon, Dominique Brown, Maxim Moreau, Bertrand Lussier, Colombe Otis, Eric Troncy
OBJECTIVE: Reporting the rate of positive (+) and negative (-) responders based on an objective outcome measure of pain-related functional disability/lameness in dogs with naturally occurring osteoarthritis (OA), and the relationship between initial lameness severity and the odds of being a (+) responder. STUDY DESIGN: Retrospective analysis of published peer-reviewed clinical trials in dogs with naturally occurring OA. ANIMALS: Dogs (n = 213) with hip and/or stifle afflicted-joints...
September 15, 2017: Veterinary Anaesthesia and Analgesia
Heidi S Lehmann, Gabrielle C Musk, Michael Laurence, Timothy H Hyndman, Jonathan Tuke, Teresa Collins, Karina B Gleerup, Craig B Johnson
OBJECTIVE: To investigate the mitigating effects of administration of local or systemic meloxicam on the electroencephalographic (EEG) and cardiovascular responses during surgical castration of Bos indicus bull calves. STUDY DESIGN: Prospective, randomized, experimental study. ANIMALS: Thirty-six 6-8 month-old Bos indicus bull calves, with a mean ± standard deviation weight of 237 ± 19 kg. METHODS: Animals were allocated randomly to three groups of 12 (group L, 260 mg of 2% lidocaine subcutaneously and intratesticularly 5 minutes prior to castration; group M, 0...
August 24, 2017: Veterinary Anaesthesia and Analgesia
João Ca Alves, Ana Mmp Dos Santos, Ângelo Dp Fernandes
OBJECTIVE: To evaluate the feasibility and effectiveness of mesotherapy in dogs compared with a positive control group. STUDY DESIGN: Experimental, randomized, blinded study. ANIMALS: Fifteen working police dogs with chronic back pain. METHODS: Animals were divided randomly into control (CG; n = 5) and treatment groups (TG; n = 10). A combination of 140 mg lidocaine, 15 mg dexamethasone and 20 mg thiocolchicoside was administered to group TG along with a 70-day course of a placebo, administered as if it was carprofen...
August 19, 2017: Veterinary Anaesthesia and Analgesia
Klaus Hopster, Stephan Neudeck, Liza Wittenberg-Voges, Sabine Br Kästner
OBJECTIVE: To compare alteration in intestinal blood flow in anaesthetized horses with changes in oral mucosa blood flow. STUDY DESIGN: Prospective, randomized clinical study. ANIMALS: Eight warmblood horses. METHODS: After induction with guaifenesin and ketamine, anaesthesia was maintained with isoflurane at 1.5 vol% in oxygen. The tissue blood flow was measured using laser Doppler flowmetry at the jejunum, colon, rectal mucosa, oesophageal mucosa and the oral mucosa...
August 18, 2017: Veterinary Anaesthesia and Analgesia
Rocio Evangelista Vaz, Dragomir I Draganov, Christelle Rapp, Frederic Avenel, Guido Steiner, Margarete Arras, Alessandra Bergadano
OBJECTIVE: 1) Determine the pharmacokinetics of tramadol hydrochloride and its active metabolite, O-desmethyltramadol (M1), after administration through different routes in female and male C57Bl/6 mice; 2) evaluate the stability of tramadol solutions; 3) identify a suitable dose regimen for prospective clinical analgesia in B6 mice. STUDY DESIGN: Prospective, randomized, blinded, parallel design. ANIMALS: Eighteen male and 18 female C57Bl/6 mice (20-30 g)...
August 16, 2017: Veterinary Anaesthesia and Analgesia
Matthew W McMillan, Kristina S Lehnus
OBJECTIVE: To identify factors contributing to the development of anaesthetic safety incidents. STUDY DESIGN: Prospective, descriptive, voluntary reporting audit of safety incidents with subsequent systems analysis. ANIMALS: All animals anaesthetized in a multispecies veterinary teaching hospital from November 2014 to October 2016. METHODS: Peri-anaesthetic incidents that risked or caused unnecessary harm to an animal were reported by anaesthetists alongside animal morbidity and mortality data...
August 5, 2017: Veterinary Anaesthesia and Analgesia
James Bowden, Ngaio J Beausoleil, Kevin J Stafford, Michael A Gieseg, Janis Bridges
OBJECTIVE: To compare the thermal nociceptive thresholds (TNTs) of dogs from three working/sport breeds. STUDY DESIGN: Experimental prospective study. ANIMALS: Thirty healthy adult dogs of mixed age, sex and reproductive status, 10 of each of three breeds: Harrier Hound, Greyhound and New Zealand Huntaway. METHODS: On one day of each week for 4 weeks, unrestrained dogs were tested six times. TNTs were measured using a remotely activated device comprising a thermode attached to the thoracic limb, controlled by a microprocessor attached to the animal...
August 3, 2017: Veterinary Anaesthesia and Analgesia
Marta Romano, Manuel Martin-Flores, Daniel M Sakai, Chia T Tseng, Luis Campoy, Robin D Gleed
OBJECTIVE: Anticholinesterase drugs may produce paradoxical neuromuscular block when administered at shallow levels of neuromuscular block. The objective of this study was to evaluate the effects of neostigmine and edrophonium when administered at near-complete reversal from nondepolarizing block in anesthetized dogs. STUDY DESIGN: Incomplete crossover, randomized, blinded experimental study. ANIMALS: A total of 12 Beagle dogs. METHODS: Each dog was anesthetized twice with propofol and maintained with isoflurane and dexmedetomidine...
August 3, 2017: Veterinary Anaesthesia and Analgesia
Anderson F da Cunha, Sara J Ramos, Michelle Domingues, Amanda Shelby, Hugues Beaufrère, Rhett Stout, Mark J Acierno
OBJECTIVES: 1) To determine which peripheral artery commonly used for invasive arterial blood pressure (IBP) monitoring yields the least bias when compared with noninvasive blood pressure (NIBP) values obtained at the antebrachium of the dog, and 2) to identify and describe differences in systolic (SAP), mean (MAP) and diastolic arterial pressures (DAP) among different anatomical locations. STUDY DESIGN: Prospective experimental study. ANIMALS: Twenty adult hound dogs weighing 24...
August 3, 2017: Veterinary Anaesthesia and Analgesia
Usama Hagag, Mohamed G Tawfiek
OBJECTIVES: To describe the 'blind' and ultrasound-guided approaches to block the maxillary nerve in donkeys. To compare the success and complication rates between the 'blind' and ultrasound-guided techniques based on staining of nerves and other structures in cadavers and assessing level of analgesia in live animals. STUDY DESIGN: Prospective anatomical and experimental study. ANIMALS: Eighteen cadaver heads and nine adult live donkeys. METHODS: Phase 1: the anatomical characteristics of the maxillary nerve and its related structures were investigated within the pterygopalatine fossa in five cadavers...
July 15, 2017: Veterinary Anaesthesia and Analgesia
Martina Mosing, Ulrike Auer, Paul MacFarlane, David Bardell, Johannes P Schramel, Stephan H Böhm, Regula Bettschart-Wolfensberger, Andreas D Waldmann
OBJECTIVE: The aim of this study was to evaluate the effect of continuous positive airway pressure (CPAP) on regional distribution of ventilation and dead space in anaesthetized horses. STUDY DESIGN: Randomized, experimental, crossover study. ANIMALS: A total of eight healthy adult horses. METHODS: Horses were anaesthetized twice with isoflurane in 50% oxygen and medetomidine as continuous infusion in dorsal recumbency, and administered in random order either CPAP (8 cmH2O) or NO CPAP for 3 hours...
July 3, 2017: Veterinary Anaesthesia and Analgesia
Niwako Ogata, Teppei Kanda, Mizuki Kawahata, Takayasu Ichikawa, Yuki Matsumoto, Waka Morimitsu, Yukiko Nishino, Takamasa Itoi, Kayo Furumoto
OBJECTIVE: To determine the effects of brimonidine tartrate ophthalmic solution on sedation, heart rate (HR), respiratory frequency (fR), rectal temperature (RT) and noninvasive mean arterial pressure (MAP) in healthy cats. STUDY DESIGN: Randomized, blinded crossover study, with 1 week washout between treatments. ANIMALS: Six healthy purpose-bred cats. METHODS: Brimonidine tartrate ophthalmic solution 0.1% (one or two drops; 58...
July 3, 2017: Veterinary Anaesthesia and Analgesia
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