journal
MENU ▼
Read by QxMD icon Read
search

Acta Pharmacologica Sinica

journal
https://www.readbyqxmd.com/read/29119971/paradoxical-lack-of-increase-in-endothelin-1-levels-in-obese-mice-possible-role-of-endothelin-b-receptors
#1
Oliver Baretella, Sookja K Chung, Aimin Xu, Paul M Vanhoutte
No abstract text is available yet for this article.
November 9, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29119970/hispidulin-mediates-apoptosis-in-human-renal-cell-carcinoma-by-inducing-ceramide-accumulation
#2
Hui Gao, Ming-Quan Gao, Jian-Jun Peng, Mei Han, Kai-Li Liu, Yan-Tao Han
Hispidulin, a polyphenolic flavonoid extracted from the traditional Chinese medicinal plant S involucrata, exhibits anti-tumor effects in a wide array of human cancer cells, mainly through growth inhibition, apoptosis induction and cell cycle arrest. However, its precise anticancer mechanisms remain unclear. In this study, we investigated the molecular mechanisms that contribute to hispidulin-induced apoptosis of human clear-cell renal cell carcinoma (ccRCC) lines Caki-2 and ACHN. Hispidulin (10, 20 μmol/L) decreased the viability of ccRCC cells in dose- and time-dependent manners without affecting that of normal tubular epithelial cells...
November 9, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29119969/tumor-targeting-efficacy-of-a-bf211-prodrug-through-hydrolysis-by-fibroblast-activation-protein-%C3%AE
#3
Xiao-Ping Chai, Guang-Long Sun, Yan-Fen Fang, Li-Hong Hu, Xuan Liu, Xiong-Wen Zhang
BF211, a bufalin (BF) derivative, exhibits stronger anti-cancer activity than BF but with potential cardiotoxicity. Fibroblast activation protein-α (FAPα) is a membrane-bound protease specifically expressed by carcinoma-associated fibroblasts, thus has been used for the selective delivery of anticancer agents. In this study, we used a FAPα-based prodrug strategy to synthesize a dipeptide (Z-Gly-Pro)-conjugated BF211 prodrug named BF211-03. BF211-03 was hydrolyzed by recombinant human FAPα (rhFAPα) and cleaved by homogenates of human colon cancer HCT-116 or human gastric cancer MGC-803 xenografts...
November 9, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29119968/time-dependent-pharmacokinetics-of-dexamethasone-and-its-efficacy-in-human-breast-cancer-xenograft-mice-a-semi-mechanism-based-pharmacokinetic-pharmacodynamic-model
#4
Jian Li, Rong Chen, Qing-Yu Yao, Sheng-Jun Liu, Xiu-Yun Tian, Chun-Yi Hao, Wei Lu, Tian-Yan Zhou
Dexamethasone (DEX) is the substrate of CYP3A. However, the activity of CYP3A could be induced by DEX when DEX was persistently administered, resulting in auto-induction and time-dependent pharmacokinetics (pharmacokinetics with time-dependent clearance) of DEX. In this study we investigated the pharmacokinetic profiles of DEX after single or multiple doses in human breast cancer xenograft nude mice and established a semi-mechanism-based pharmacokinetic/pharmacodynamic (PK/PD) model for characterizing the time-dependent PK of DEX as well as its anti-cancer effect...
November 9, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29119967/rhynchophylla-total-alkaloid-rescues-autophagy-decreases-oxidative-stress-and-improves-endothelial-vasodilation-in-spontaneous-hypertensive-rats
#5
Chao Li, Feng Jiang, Yun-Lun Li, Yue-Hua Jiang, Wen-Qing Yang, Jie Sheng, Wen-Juan Xu, Qing-Jun Zhu
Autophagy plays an important role in alleviating oxidative stress and stabilizing atherosclerotic plaques. However, the potential role of autophagy in endothelial vasodilation function has rarely been studied. This study aimed to investigate whether rhynchophylla total alkaloid (RTA) has a positive role in enhancing autophagy through decreasing oxidative stress, and improving endothelial vasodilation. In oxidized low-density lipoprotein (ox-LDL)-treated human umbilical vein endothelial cells (HUVECs), RTA (200 mg/L) significantly suppressed ox-LDL-induced oxidative stress through rescuing autophagy, and decreased cell apoptosis...
November 9, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29119966/cucurbitacin-i-inhibits-stat3-but-enhances-stat1-signaling-in-human-cancer-cells-in-vitro-through-disrupting-actin-filaments
#6
Hui Guo, Shan Kuang, Qiao-Ling Song, Man Liu, Xiao-Xiao Sun, Qiang Yu
STAT1 and STAT3 are two important members of the STAT (signal transducers and activators of transcription) protein family and play opposing roles in regulating cancer cell growth. Suppressing STAT3 and/or enhancing STAT1 signaling are considered to be attractive anticancer strategies. Cucurbitacin I (CuI) isolated from the cucurbitacin family was reported to be an inhibitor of STAT3 signaling and a disruptor of actin cytoskeleton. In this study we investigated the function and mechanisms of CuI in regulating STAT signaling in human cancer cells in vitro...
November 9, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29094729/chinese-herbal-formula-fuzheng-huayu-alleviates-ccl4-induced-liver-fibrosis-in-rats-a-transcriptomic-and-proteomic-analysis
#7
Shu Dong, Fei-Fei Cai, Qi-Long Chen, Ya-Nan Song, Yang Sun, Bin Wei, Xiao-Yan Li, Yi-Yang Hu, Ping Liu, Shi-Bing Su
Liver fibrosis is a consequence of chronic liver disease that can progress to liver cirrhosis or even hepatocarcinoma. Fuzheng Huayu (FZHY), a Chinese herbal formula, has been shown to exert anti-fibrotic effects. To better understand the molecular mechanisms underlying the anti-fibrotic effects of FZHY, we analyzed transcriptomic and proteomic combination profiles in CCl4-induced liver fibrosis in rats, which were treated with extracted FZHY powder (0.35 g/kg/d, ig) for 3 weeks. We showed that FZHY administration significantly improved liver function, alleviated hepatic inflammatory and fibrotic changes, and decreased the hydroxyproline content in the livers of CCl4-treated rats...
November 2, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29094728/enhancing-inactivation-rather-than-reducing-activation-of-nav1-7-channels-by-a-clinically-effective-analgesic-cnv1014802
#8
Yue-Ming Zheng, Wan-Fu Wang, Yan-Fen Li, Yong Yu, Zhao-Bing Gao
The Nav1.7 channel represents a promising target for pain relief. In the recent decades, a number of Nav1.7 channel inhibitors have been developed. According to the effects on channel kinetics, these inhibitors could be divided into two major classes: reducing activation or enhancing inactivation. To date, however, only several inhibitors have moved forward into phase 2 clinical trials and most of them display a less than ideal analgesic efficacy, thus intensifying the controversy regarding if an ideal candidate should preferentially affect the activation or inactivation state...
November 2, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29094727/a-pivotal-role-for-the-activation-of-trpv3-channel-in-itch-sensations-induced-by-the-natural-skin-sensitizer-carvacrol
#9
Ting-Ting Cui, Gong-Xin Wang, Ning-Ning Wei, KeWei Wang
Itching is an intricate, common symptom of dermatologic and systemic diseases, and both TRPV3 and TRPA1 channels have been suggested to function as downstream effector targets. But the relative contributions of TRPV3 and TRPA1 to itch sensation in vivo remain unclear. To dissect the role of TRPA1 or TRPV3 in the cutaneous sensation of itching, we took the advantage of a natural compound carvacrol from oregano, and examined its effect on the induction of scratching behavior in mice. We showed that the intradermal injection of carvacrol (0...
November 2, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29072259/barbaloin-inhibits-ventricular-arrhythmias-in-rabbits-by-modulating-voltage-gated-ion-channels
#10
Zhen-Zhen Cao, You-Jia Tian, Jie Hao, Pei-Hua Zhang, Zhi-Pei Liu, Wan-Zhen Jiang, Meng-Liu Zeng, Pei-Pei Zhang, Ji-Hua Ma
Barbaloin (10-β-D-glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-9(10H)-anthracenone) is extracted from the aloe plant and has been reported to have anti-inflammatory, antitumor, antibacterial, and other biological activities. Here, we investigated the effects of barbaloin on cardiac electrophysiology, which has not been reported thus far. Cardiac action potentials (APs) and ionic currents were recorded in isolated rabbit ventricular myocytes using whole-cell patch-clamp technique. Additionally, the antiarrhythmic effect of barbaloin was examined in Langendorff-perfused rabbit hearts...
October 26, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29072258/a-metabolic-mechanism-analysis-of-fuzheng-huayu-formula-for-improving-liver-cirrhosis-with-traditional-chinese-medicine-syndromes
#11
Ya-Nan Song, Jian Chen, Fei-Fei Cai, Yi-Yu Lu, Qi-Long Chen, Yong-Yu Zhang, Ping Liu, Shi-Bing Su
Fuzheng-Huayu formula (FZHY), a Chinese herbal mixture pre¬scription, has been proven effective in treating liver fibrosis and cirrhosis in both clinical trials and animal experiments. In this study we assessed the metabolic mechanisms of traditional Chinese medicine (TCM) syndrome-based FZHY treatment in liver cirrhosis (LC). A total of 113 participants, including 50 healthy controls and 63 LC patients, were recruited. According to the diagnosis and differentiation of the TCM syndromes, the LC patients were classified into 5 TCM syndrome groups including the liver stagnation syndrome (LSS), spleen deficiency and damp overabun¬dance syndrome (SDDOS), damp-heat accumulation syndrome (DHAS), liver-kidney Yin deficiency syndrome (LKYDS), and blood stagnation syndrome (BSS), and administered FZHY for 6 months...
October 26, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29072257/therapeutic-effects-of-a-taurine-magnesium-coordination-compound-on-experimental-models-of-type-2-short-qt-syndrome
#12
Meng-Yao An, Kai Sun, Yan Li, Ying-Ying Pan, Yong-Qiang Yin, Yi Kang, Tao Sun, Hong Wu, Wei-Zhen Gao, Jian-Shi Lou
Short QT syndrome (SQTS) is a genetic arrhythmogenic disease that can cause malignant arrhythmia and sudden cardiac death. The current therapies for SQTS have application restrictions. We previously found that Mg· (NH2CH2CH2SO3)2· H2O, a taurine-magnesium coordination compound (TMCC) exerted anti-arrhythmic effects with low toxicity. In this study we established 3 different models to assess the potential anti-arrhythmic effects of TMCC on type 2 short QT syndrome (SQT2). In Langendorff guinea pig-perfused hearts, perfusion of pinacidil (20 μmol/L) significantly shortened the QT interval and QTpeak and increased rTp-Te (P<0...
October 26, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29072256/rapamycin-inhibits-ox-ldl-induced-inflammation-in-human-endothelial-cells-in-vitro-by-inhibiting-the-mtorc2-pkc-c-fos-pathway
#13
Juan-Juan Sun, Xiao-Wei Yin, Hui-Hui Liu, Wen-Xiu Du, Lu-Yao Shi, Ya-Bo Huang, Fen Wang, Chun-Feng Liu, Yong-Jun Cao, Yan-Lin Zhang
Rapamycin and its derivative possess anti-atherosclerosis activity, but its effects on adhesion molecule expression and macrophage adhesion to endothelial cells during atherosclerosis remain unclear. In this study we explored the effects of rapamycin on ox-LDL-induced adhesion molecule expression and macrophage adhesion to endothelial cells in vitro and the underlying mechanisms. Ox-LDL (6-48 μg/mL) dose-dependently increased the protein levels of two adhesion molecules, intercellular adhesion molecule-1 (ICAM-1) and E-selectin, in human umbilical vein endothelial cells (HUVECs), whereas pretreatment with rapamycin (1-10 μmol/L) dose-dependently inhibited ox-LDL-induced increase in the adhesion molecule expression and macrophage adhesion to endothelial cells...
October 26, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29047461/hematopoietic-stem-cell-derived-exosomes-promote-hematopoietic-differentiation-of-mouse-embryonic-stem-cells-in-vitro-via-inhibiting-the-mir126-notch1-pathway
#14
Feng-Ling Liao, Lin Tan, Hua Liu, Jin-Ju Wang, Xiao-Tang Ma, Bin Zhao, Yan-Fang Chen, Ji Bihl, Yi Yang, Ri-Ling Chen
Cell-derived exosomes (EXs) can modulate target cell differentiation via microRNAs (miRs) that they carried. Previous studies have shown that miR126 is highly expressed in hematopoietic stem cells (HSCs) and plays a role in hematopoiesis via modulating the Notch pathway that participates in progenitors' cell fate decisions. In this study we investigated whether HSC-derived EXs (HSC-EXs) could affect the differentiation of mouse embryonic stem cells (ESCs) into HSCs. We prepared HSC-EXs(con), HSC-EXs(sc) and HSC-EXs(miR126) from control HSCs and the HSCs transfected with scramble control or miR126 mimics, respectively...
October 19, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29047460/computational-insights-into-the-subtype-selectivity-and-message-address-efficacy-mechanisms-of-opioid-receptors-through-jdtic-binding-and-unbinding
#15
Jian-Xin Cheng, Tao Cheng, Wei-Hua Li, Gui-Xia Liu, Wei-Liang Zhu, Yun Tang
In drug design and discovery, binding affinity and selectivity are two basic properties of a drug candidate. Opioid receptors (ORs) are the main targets of strong analgesics. Like some other class A members of G-protein-coupled receptors (GPCRs), ORs exhibit complex selectivity on their ligands. The diversity of binding activity and selectivity among opioids has deeply attracted researchers for a long time. To investigate the subtype selectivity of μ, δ and κ ORs in detail, using the κ-selective antagonist JDTic as a probe, we performed a series of computational simulations, including molecular dynamics and metadynamics, on JDTic-μ/δ/κ-OR complexes...
October 19, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29047459/protostemonine-effectively-attenuates-lipopolysaccharide-induced-acute-lung-injury-in-mice
#16
Ya-Xian Wu, Hui-Qiong He, Yun-Juan Nie, Yun-He Ding, Lei Sun, Feng Qian
Protostemonine (PSN) is the main anti-inflammatory alkaloid extracted from the roots of Stemona sessilifolia (known as "Baibu" in traditional Chinese medicine). Here, we reported the inhibitory effects of PSN on lipopolysaccharide (LPS)-induced macrophage activation in vitro and LPS-induced acute lung injury in mice. Macrophage cell line RAW264.7 cells and mouse bone marrow-derived macrophages (BMDMs) were treated with PSN (1, 3, 10, 30 and 100 μmol/L) for 0.5 h and then challenged with LPS (0.1 μg/mL) for 24 h...
October 19, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29022576/xueshuantong-injection-lyophilized-combined-with-salvianolate-lyophilized-injection-protects-against-focal-cerebral-ischemia-reperfusion-injury-in-rats-through-attenuation-of-oxidative-stress
#17
Fu-Jiang Wang, Shao-Xia Wang, Li-Juan Chai, Yue Zhang, Hong Guo, Li-Min Hu
Salvianolate lyophilized injection (SLI) and Xueshuantong injection (lyophilized) (XST) are two herbal standardized preparations that have been widely used in China for the treatment of acute cerebral infarction. In this study, we investigated the neuroprotective effects of SLI combined with XST in a rat model of middle cerebral artery occlusion-reperfusion (MCAO/R). Wistar rats were subjected to 1.5 h of MCAO followed by reperfusion for 3 h, then were treated with SLI or XST alone, or with their combinations via tail vein injection daily for 3 d...
October 12, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29022574/osthole-prevents-acetaminophen-induced-liver-injury-in-mice
#18
Yun Cai, Wu Sun, Xin-Xin Zhang, Yan-Die Lin, Hao Chen, Hao Li
Acetaminophen (APAP) overdose leads to severe hepatotoxicity. Osthole, a natural coumarin found in traditional Chinese medicinal herbs, has therapeutic potential in the treatment of various diseases. In this study, we investigated the effects of osthole against APAP-induced hepatotoxicity in mice. Mice were administered osthole (100 mg·kg(-1)·d(-1), ip) for 3 d, then on the fourth day APAP (300 mg/kg, ip) was co-administered with osthole. The mice were euthanized post-APAP, their serum and livers were collected for analysis...
October 12, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28933425/carnosine-suppresses-oxygen-glucose-deprivation-recovery-induced-proliferation-and-migration-of-reactive-astrocytes-of-rats-in-vitro
#19
Li Ou-Yang, Yuan Liu, Bing-Yu Wang, Pei Cao, Jing-Jing Zhang, Yu-Yan Huang, Yao Shen, Jian-Xin Lyu
Glial scar formation resulted from excessive astrogliosis limits axonal regeneration and impairs recovery of function, thus an intervention to ameliorate excessive astrogliosis is crucial for the recovery of neurological function after cerebral ischemia. In this study we investigated the effects of carnosine, an endogenous water-soluble dipeptide (β-alanyl-L-histidine), on astrogliosis of cells exposed to oxygen-glucose deprivation/recovery (OGD/R) in vitro. Primary cultured rat astrocytes exhibited a significant increase in proliferation at 24 h recovery after OGD for 2 h...
September 21, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28933424/the-efficacy-and-safety-of-cilostazol-as-an-alternative-to-aspirin-in-chinese-patients-with-aspirin-intolerance-after-coronary-stent-implantation-a-combined-clinical-study-and-computational-system-pharmacology-analysis
#20
Ying Xue, Zhi-Wei Feng, Xiao-Ye Li, Zi-Heng Hu, Qing Xu, Zi Wang, Jia-Hui Cheng, Hong-Tao Shi, Qi-Bing Wang, Hong-Yi Wu, Xiang-Qun Xie, Qian-Zhou Lv
Dual antiplatelet therapy (DAT) with aspirin and clopidogrel is the standard regimen to achieve rapid platelet inhibition and prevent thrombotic events. Currently, little information is available regarding alternative antiplatelet therapy in patients with an allergy or intolerance to aspirin. Although cilostazol is already a common alternative to aspirin in clinical practice in China, its efficacy and safety remain to be determined. We retrospectively analyzed 613 Chinese patients who had undergone primary percutaneous coronary intervention (PCI)...
September 21, 2017: Acta Pharmacologica Sinica
journal
journal
35064
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"