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Asian Journal of Andrology

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https://www.readbyqxmd.com/read/28597850/the-role-of-peroxisome-proliferator-activated-receptor-gamma-in-prostate-cancer
#1
REVIEW
Catherine Elix, Sumanta K Pal, Jeremy O Jones
Despite great progress in the detection and treatment of prostate cancer, this disease remains an incredible health and economic burden. Although androgen receptor (AR) signaling plays a key role in the development and progression of prostate cancer, aberrations in other molecular pathways also contribute to the disease, making it essential to identify and develop drugs against novel targets, both for the prevention and treatment of prostate cancer. One promising target is the peroxisome proliferator-activated receptor gamma (PPARγ) protein...
June 9, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28597849/association-between-diacylglycerol-kinase-kappa-variants-and-hypospadias-susceptibility-in-a-han-chinese-population
#2
Hua Xie, Xiao-Ling Lin, Song Zhang, Ling Yu, Xiao-Xi Li, Yi-Chen Huang, Yi-Qing Lyu, Hai-Tao Chen, Jianfeng Xu, Fang Chen
Previous genome-wide association studies have identified variants in the diacylglycerol kinase kappa (DGKK) gene associated with hypospadias in populations of European descent. However, no variants of DGKK were confirmed to be associated with hypospadias in a recent Han Chinese study population, likely due to the limited number of single-nucleotide polymorphisms (SNPs) included in the analysis. In this study, we aimed to address the inconsistent results and evaluate the association between DGKK and hypospadias in the Han Chinese population through a more comprehensive analysis of DGKK variants...
June 9, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28566559/mri-feature-analysis-of-uncommon-prostatic-malignant-tumors
#3
LETTER
Zhao-Yan Feng, Xiang-De Min, Liang Wang, Ba-Sen Li, Zan Ke, Pei-Pei Zhang, Zhen Kang
No abstract text is available yet for this article.
May 30, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28566558/testosterone-treatment-in-older-men-glass-half-empty-or-half-full
#4
Brendan J Nolan, Mathis Grossmann
No abstract text is available yet for this article.
May 26, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28474611/patient-reported-ejaculatory-function-and-satisfaction-in-men-with-lower-urinary-tract-symptoms-benign-prostatic-hyperplasia
#5
Min Chul Cho, Jung Kwon Kim, Sang Hoon Song, Sung Yong Cho, Sang Wook Lee, Soo Woong Kim, Jae-Seung Paick
This study aimed to investigate perceived ejaculatory function/satisfaction before treatment for lower urinary tract symptoms (LUTS)/benign prostatic hyperplasia (BPH) and to identify associations between specific categories of ejaculatory dysfunctions (EjDs) and LUTS. A total of 1574 treatment-naïve men with LUTS/BPH were included in this study. All patients underwent routine evaluation for LUTS/BPH including the International Index of Erectile Function and a 5-item questionnaire developed to assess ejaculatory volume/force/pain/satisfaction/latency time...
May 2, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28440262/risk-of-complications-and-urinary-incontinence-following-cytoreductive-prostatectomy-a-multi-institutional-study
#6
Dae Keun Kim, Jaspreet Singh Parihar, Young Suk Kwon, Sinae Kim, Brian Shinder, Nara Lee, Nicholas Farber, Thomas Ahlering, Douglas Skarecky, Bertram Yuh, Nora Ruel, Wun-Jae Kim, Koon Ho Rha, Isaac Yi Kim
Emerging evidence has suggested that cytoreductive prostatectomy (CRP) allows superior oncologic control when compared to current standard of care androgen deprivation therapy alone. However, the safety and benefit of cytoreduction in metastatic prostate cancer (mPCa) has not been proven. Therefore, we evaluated the incidence of complications following CRP in men newly diagnosed with mPCa. A total of 68 patients who underwent CRP from 2006 to 2014 at four tertiary surgical centers were compared to 598 men who underwent radical prostatectomy for clinically localized prostate cancer (PCa)...
April 25, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28440265/role-of-jun-amino-terminal-kinase-jnk-in-apoptosis-of-cavernosal-tissue-during-acute-phase-after-cavernosal-nerve-injury
#7
Won Hoon Song, Hwancheol Son, Soo Woong Kim, Jae-Seung Paick, Min Chul Cho
The present study aimed to identify which mitogen-activated protein kinase (p38 or Jun amino-terminal kinase [JNK]) was involved in cavernosal apoptosis during the acute phase after cavernosal nerve crush injury (CNCI) in rats to ameliorate apoptosis of cavernosal tissue, such as smooth muscle (SM). A total of twenty 10-week-old male Sprague-Dawley rats were divided equally into two groups: sham surgery (S) and CNCI (I). The I group approximated the clinical situation of men undergoing radical prostatectomy using two 60-second compressions of both CNs with a microsurgical vascular clamp...
April 18, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28440264/use-of-testicular-sperm-for-intracytoplasmic-sperm-injection-in-men-with-high-sperm-dna-fragmentation-a-swot-analysis
#8
Sandro C Esteves, Matheus Roque, Nicolás Garrido
Spermatozoa retrieved from the testis of men with high levels of sperm DNA fragmentation (SDF) in the neat semen tend to have better DNA quality. Given the negative impact of SDF on the outcomes of Assisted Reproductive Technology (ART), an increased interest has emerged about the use of testicular sperm for intracytoplasmic sperm injection (Testi-ICSI). In this article, we used a SWOT (strengths, weaknesses, opportunities, and threats) analysis to summarize the advantages and drawbacks of this intervention...
April 18, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28440263/suprapubic-cystostomy-versus-nonsuprapubic-cystostomy-during-monopolar-transurethral-resection-of-prostate-a-propensity-score-matched-analysis
#9
Run-Qi Guo, Yi-Sen Meng, Wei Yu, Kai Zhang, Ben Xu, Yun-Xiang Xiao, Shi-Liang Wu, Bai-Nian Pan
We aim to reassess the safety of the monopolar transurethral resection of the prostate (M-TURP) without suprapubic cystostomy at our institution over the past decade. This retrospective study was conducted in patients who underwent M-TURP at Peking University First Hospital between 2003 and 2013. A total of 1680 patients who had undergone M-TURP were identified, including 539 patients in the noncystostomy group and 1141 patients in the cystostomy group. After propensity score matching, the number of patients in each group was 456...
April 18, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28382926/aldosterone-induces-inflammatory-cytokines-in-penile-corpus-cavernosum-by-activating-the-nf-%C3%AE%C2%BAb-pathway
#10
Fei Wu, Zu-Quan Xiong, Shan-Hua Mao, Ji-Meng Hu, Jian-Qing Wang, Hao-Wen Jiang, Qiang Ding
Emerging evidence indicates that aldosterone and mineralocorticoid receptors (MRs) are associated with the pathogenesis of erectile dysfunction. However, the molecular mechanisms remain largely unknown. In this study, freshly isolated penile corpus cavernosum tissue from rats was treated with aldosterone, with or without MRs inhibitors. Nuclear factor (NF)-kappa B (NF-κB) activity was evaluated by real-time quantitative PCR, luciferase assay, and immunoblot. The results demonstrated that mRNA levels of the NF-κB target genes, including inhibitor of NF-κB alpha (IκB-α), NF-κB1, tumor necrosis factor-alpha (TNF-α), and interleukin 6 (IL-6), were higher after aldosterone treatment...
April 4, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28382925/combined-analysis-of-crmp4-methylation-levels-and-capra-s-score-predicts-metastasis-and-outcomes-in-prostate-cancer-patients
#11
Qun-Xiong Huang, Chu-Tian Xiao, Zheng Chen, Min-Hua Lu, Jun Pang, Jin-Ming Di, Zi-Huan Luo, Xin Gao
The present study analyzed the predictive value of combined analysis of collapsin response mediator protein 4 (CRMP4) methylation levels and the Cancer of the Prostate Risk Assessment (CAPRA-S) Postsurgical score of patients who required adjuvant hormone therapy (AHT) after radical prostatectomy (RP). We retrospectively analyzed 305 patients with prostate cancer (PCa) who received RP and subsequent androgen deprivation therapy (ADT). Two hundred and thirty patients with clinically high-risk PCa underwent immediate ADT, and 75 patients with intermediate risk PCa underwent deferred ADT...
April 4, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28272058/psma-targeted-imaging-of-prostate-cancer-evolution-of-a-success-story
#12
Tobias Maurer, Matthias Eiber
No abstract text is available yet for this article.
May 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/27976632/evaluation-of-99mtc-labeled-psma-spect-ct-imaging-in-prostate-cancer-patients-who-have-undergone-biochemical-relapse
#13
Heng-Chuan Su, Yao Zhu, Guo-Wen Ling, Si-Long Hu, Xiao-Ping Xu, Bo Dai, Ding-Wei Ye
Using conventional imaging modalities, it is difficult to detect recurrent lesions in prostate cancer patients who have undergone biochemical relapse, especially in patients with low prostate-specific antigen (PSA) levels. We retrospectively reviewed the files of fifty patients with histopathologically confirmed prostate cancer who underwent 99mTc-labeled prostate-specific membrane antigen (PSMA) single-photon emission computed tomography (SPECT)/computed tomography (CT), magnetic resonance imaging (MRI), and bone scan within a 30-day period...
May 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/27768007/the-effectiveness-of-zinc-supplementation-in-men-with-isolated-hypogonadotropic-hypogonadism
#14
Yan-Ling Liu, Man-Na Zhang, Guo-Yu Tong, Shou-Yue Sun, Yan-Hua Zhu, Ying Cao, Jie Zhang, Hong Huang, Ben Niu, Hong Li, Qing-Hua Guo, Yan Gao, Da-Long Zhu, Xiao-Ying Li
A multicenter, open-label, randomized, controlled superiority trial with 18 months of follow-up was conducted to investigate whether oral zinc supplementation could further promote spermatogenesis in males with isolated hypogonadotropic hypogonadism (IHH) receiving sequential purified urinary follicular-stimulating hormone/human chorionic gonadotropin (uFSH/hCG) replacement. Sixty-seven Chinese male IHH patients were recruited from the Departments of Endocrinology in eight tertiary hospitals and randomly allocated into the sequential uFSH/hCG group (Group A, n = 34) or the sequential uFSH plus zinc supplementation group (Group B, n = 33)...
May 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/27080477/epigallocatechin-3-gallate-ameliorates-erectile-function-in-aged-rats-via-regulation-of-prmt1-ddah-adma-nos-metabolism-pathway
#15
Dong Chen, Ke-Qin Zhang, Bo Li, Ding-Qi Sun, Hui Zhang, Qiang Fu
Aging-related ED is predominantly attributed to neurovascular dysfunction mediated by NO suppression and increased oxidative stress in penis. The alterations of protein arginine methyltransferases 1 (PRMT1)/dimethylarginine dimethylaminohydrolase (DDAH)/asymmetrical dimethylarginine (ADMA)/NO synthase (NOS) pathway regulate NO production in the vascular endothelium. Epigallocatechin-3-gallate (EGCG) is one of the most abundant and antioxidative ingredients isolated from green tea. In the present study, 40 Sprague-Dawley rats were randomly distributed into four groups: one young rat group and three aged rat groups treated with daily gavage feedings of EGCG at doses of 0, 10 mg kg-1 and 100 mg kg-1 for 12 weeks, respectively...
May 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/27004539/metabolic-syndrome-in-white-european-men-presenting-for-secondary-couple-s-infertility-an-investigation-of-the-clinical-and-reproductive-burden
#16
Eugenio Ventimiglia, Paolo Capogrosso, Alessandro Serino, Luca Boeri, Michele Colicchia, Giovanni La Croce, Roberta Scano, Enrico Papaleo, Rocco Damiano, Francesco Montorsi, Andrea Salonia
We aimed to determine the impact of metabolic syndrome (MetS) on reproductive function in men with secondary infertility, a condition that has received relatively little attention from researchers. Complete demographic, clinical, and laboratory data from 167 consecutive secondary infertile men were analyzed. Health-significant comorbidities were scored with the Charlson Comorbidity Index (CCI; categorised 0 vs 1 vs 2 or higher). NCEP-ATP III criteria were used to define MetS. Semen analysis values were assessed based on the 2010 World Health Organization (WHO) reference criteria...
May 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/27004538/a-giant-adult-paratesticular-rhabdomyosarcomar
#17
LETTER
Xu Chen, Xiang-Zhou Sun, Wen-Lin Xie, Qiang-Sheng Dai, Shan Hu, Chun-Hua Deng
No abstract text is available yet for this article.
May 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/26975486/use-of-a-disposable-circumcision-suture-device-versus-conventional-circumcision-a-systematic-review-and-meta-analysis
#18
Zhong-Chao Huo, Gang Liu, Xiao-Yan Li, Fei Liu, Wen-Ju Fan, Ru-Hua Guan, Pei-Feng Li, De-Yang Mo, Yong-Zhi He
This systematic review assessed the safety and efficacy of the disposable circumcision suture device (DCSD) and conventional circumcision (CC) in the treatment of redundant prepuce and phimosis. Two independent reviewers conducted a literature search for randomized controlled trials (RCTs) using the DCSD and CC for the treatment of redundant prepuce or phimosis in China and abroad. Nine RCTs (1898 cases) were included. Compared with the CC group, the DCSD group had a shorter operative time (standardized mean difference [SMD] = -21...
May 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/26975485/inverse-correlation-between-reactive-oxygen-species-in-unwashed-semen-and-sperm-motion-parameters-as-measured-by-a-computer-assisted-semen-analyzer
#19
Teppei Takeshima, Yasushi Yumura, Kengo Yasuda, Hiroyuki Sanjo, Shinnosuke Kuroda, Hiroyuki Yamanaka, Akira Iwasaki
This study investigated the correlation between sperm motion parameters obtained by a computer-assisted semen analyzer and levels of reactive oxygen species in unwashed semen. In total, 847 patients, except for azoospermic patients were investigated. At the time of each patient's first consultation, semen parameters were measured using SMAS™ or CellSoft 3000™, and production of reactive oxygen species was measured using a computer-driven LKB Wallac Luminometer 1251 Analyzer. The patients were divided into two groups: reactive oxygen species - positive and negative...
May 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/26975484/human-semen-quality-and-the-secondary-sex-ratio
#20
Jisuk Bae, Sungduk Kim, Zhen Chen, Michael L Eisenberg, Germaine M Buck Louis
The aim of this study was to evaluate the association between semen quality and the secondary sex ratio (SSR), defined as the ratio of male to female live births. Our study cohort comprised 227 male partners who were enrolled prior to conception in Michigan and Texas between 2005 and 2009, and prospectively followed through delivery of a singleton birth. The male partners provided a baseline and a follow-up semen sample a month apart. Semen analysis was conducted to assess 27 parameters including five general characteristics, six sperm head measures, 14 morphology measures, and two sperm chromatin stability assay measures...
May 2017: Asian Journal of Andrology
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