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Asian Journal of Andrology

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https://www.readbyqxmd.com/read/29148520/an-in-vitro-prototype-of-a-porcine-biomimetic-testis-like-cell-culture-system-a-novel-tool-for-the-study-of-reassembled-sertoli-and-leydig-cells
#1
Iva Arato, Giovanni Luca, Francesca Mancuso, Catia Bellucci, Cinzia Lilli, Mario Calvitti, Barbara C Hansen, Domenico Milardi, Giuseppe Grande, Riccardo Calafiore
At present, there is no reliable in vitro assembled prepubertal testis-like biomimetic organ culture system designed to assess the functional effects of human gonadotropins on Sertoli and Leydig cells. Spermatogenesis is regulated by endocrine, paracrine, and juxtacrine factors (testicular cross-talk), mainly orchestrated by gonadotropins such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) that play a pivotal role by stimulating Leydig and Sertoli cells, respectively. The aim of our study was to set up an in vitro prepubertal porcine bioengineered construct as a new model for experimental studies on reassembled Sertoli and Leydig cells...
November 10, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29111541/lipoxin-a4-improves-erectile-dysfunction-in-rats-with-type-i-diabetes-by-inhibiting-oxidative-stress-and-corporal-fibrosis
#2
Kai Cui, Zhe Tang, Chuan-Chang Li, Tao Wang, Ke Rao, Shao-Gang Wang, Ji-Hong Liu, Zhong Chen
Previous studies have shown that oxidative stress and corporal fibrosis in penile tissues of rats were key pathological factors of erectile dysfunction induced by diabetic mellitus (DMED). Lipoxin A4 (LXA4) was reported to inhibit oxidative stress and fibrosis diseases, while whether it could exert a protective role on erectile function was not clear. Type I diabetic mellitus (DM) was induced in thirty male 10-week-old Sprague-Dawley rats using streptozotocin. Ten weeks later, twenty-two rats with DMED confirmed by an apomorphine test were divided into two groups: the DMED group (n = 11) and the DMED + LXA4 group (n = 11; LXA4 injection daily for 4 weeks)...
November 7, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29111540/transcription-and-regulation-of-hepatitis-b-virus-genes-in-host-sperm-cells
#3
Ying Zhong, Dong-Ling Liu, Mohamed Morsi M Ahmed, Peng-Hao Li, Xiao-Ling Zhou, Qing-Dong Xie, Xiao-Qing Xu, Ting-Ting Han, Zhi-Wei Hou, Ji-Hua Huang, Lan Xu, Tian-Hua Huang
To investigate whether transcription of hepatitis B virus (HBV) gene occurs in human sperm, total RNA was extracted from sperm of patients with chronic HBV infection (test-1), from donor sperm transfected with a plasmid containing the full-length HBV genome (test-2), and from nontransfected donor sperm (control), used as the template for reverse transcription-polymerase chain reaction (RT-PCR). Positive bands for HBV DNA were observed in the test groups but not in the control. Next, to identify the role of host genes in regulating viral gene transcription in sperm, total RNA was extracted from 2-cell embryos derived from hamster oocytes fertilized in vitro by HBV-transfected (test) or nontransfected (control) human sperm and successively subjected to SMART-PCR, suppression subtractive hybridization, T/A cloning, bacterial amplification, microarray hybridization, sequencing and the Basic Local Alignment Search Tool (BLAST) search to isolate differentially expressed genes...
November 7, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29111539/external-validation-and-newly-development-of-a-nomogram-to-predict-overall-survival-of-abiraterone-treated-castration-resistant-patients-with-metastatic-prostate-cancer
#4
Yun-Jie Yang, Guo-Wen Lin, Gao-Xiang Li, Bo Dai, Ding-Wei Ye, Jun-Long Wu, Hu-Yang Xie, Yao Zhu
Abiraterone acetate is approved for the treatment of castration-resistant prostate cancer (CRPC); however, its effects vary. An accurate prediction model to identify patient groups that will benefit from abiraterone treatment is therefore urgently required. The Chi model exhibits a good profile for risk classification, although its utility for the chemotherapy-naive group is unclear. This study aimed to externally validate the Chi model and develop a new nomogram to predict overall survival (OS). We retrospectively analyzed a cohort of 110 patients...
November 7, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29111538/hormone-levels-following-surgical-and-medical-castration-defining-optimal-androgen-suppression
#5
LETTER
Michael T Schweizer, Michael L Hancock, Robert H Getzenberg, Evan Y Yu
No abstract text is available yet for this article.
November 7, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29086760/penile-cutaneous-horn-a-rare-case-report-and-review-of-the-literature
#6
LETTER
Ying Wang, Min-Qi Tu, Xiao-Jing Li, Qiang Fu, Guo-Wei Shi
No abstract text is available yet for this article.
October 27, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29086759/a-retrospective-review-of-single-institution-outcomes-with-robotic-assisted-microsurgical-varicocelectomy
#7
Andrew McCullough, Leon Elebyjian, Joseph Ellen, Clay Mechlin
We report the largest single-center experience with robotic-assisted microscopic varicocelectomy (RAMV) in male infertility. From August 2012 to February 2015, men with infertility of at least a year and varicoceles underwent RAMV by a single surgeon. Varicocele was diagnosed on physical examination and confirmed by ultrasound by a single ultrasonographer. Preoperative hormone panel, semen analyses, and testicular Doppler ultrasound were obtained from all men and repeated at 3 months. One hundred and forty consecutive men (258 varicocelectomies) were included...
October 27, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29063869/role-of-chemotherapy-in-prostate-cancer
#8
REVIEW
Rita Nader, Joelle El Amm, Jeanny B Aragon-Ching
Chemotherapy in prostate cancer (PCa) has undergone dramatic landscape changes. While earlier studies utilized varying chemotherapy regimens which were found to be largely palliative in nature and hardly resulted in durable or meaningful responses, docetaxel resulted in the first chemotherapy agent that showed improvement in overall survival in metastatic castration-resistant prostate cancer (mCRPC). However, combination chemotherapy or any agents added to docetaxel have failed to yield incremental benefits...
October 20, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28980534/fertility-achieved-through-in-vitro-fertilization-in-a-male-patient-with-48-xxyy-syndrome
#9
LETTER
De-Feng Liu, Lian-Ming Zhao, Kai Hong, Jia-Ming Mao, Yu-Zhuo Yang, Zhe Zhang, Hui Jiang
No abstract text is available yet for this article.
October 3, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28959941/nondegloving-technique-for-peyronie-s-disease-with-penile-prosthesis-implantation-and-double-dorsal-ventral-patch-graft
#10
Andrew Fang, Run Wang
No abstract text is available yet for this article.
September 29, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28948940/radical-prostatectomy-in-patients-aged-75-years-or-older-review-of-the-literature
#11
REVIEW
Philipp Mandel, Thenappan Chandrasekar, Felix K Chun, Hartwig Huland, Derya Tilki
Given the demographic trends toward a considerably longer life expectancy, the percentage of elderly patients with prostate cancer will increase further in the upcoming decades. Therefore, the question arises, should patients ≥75 years old be offered radical prostatectomy and under which circumstances? For treatment decision-making, life expectancy is more important than biological age. As a result, a patient's health and mental status has to be determined and radical treatment should only be offered to those who are fit...
September 26, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28948939/the-prevalence-and-risk-factors-of-prostatic-calcification-an-analysis-of-68-705-subjects
#12
LETTER
Zhuang Tang, Xiao-Mei Wu, Qiang Wei, Lin-Na Wu
No abstract text is available yet for this article.
September 26, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28905815/psa-time-to-nadir-as-a-prognostic-factor-of-first-line-docetaxel-treatment-in-castration-resistant-prostate-cancer-evidence-from-patients-in-northwestern-china
#13
Kai-Jie Wu, Xin-Qi Pei, Ge Tian, Da-Peng Wu, Jin-Hai Fan, Yu-Mei Jiang, Da-Lin He
Docetaxel-based chemotherapy remains the first-line treatment for patients with metastatic castration-resistant prostate cancer (mCRPC) in China; however, the prognostic factors associated with effects in these patients are still controversial. In this study, we retrospectively reviewed the data from 71 eligible Chinese patients who received docetaxel chemotherapy from 2009 to 2016 in our hospital and experienced a reduction of prostate-specific antigen (PSA) level ≥50% during the treatment and investigated the potential role of time to nadir (TTN) of PSA...
September 12, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28879867/psa-screening-for-whom-and-when
#14
Peter Albers
No abstract text is available yet for this article.
September 5, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28879866/management-and-outcomes-of-penile-fracture-a-retrospective-analysis-of-62-cases-with-long-term-assessment
#15
LETTER
Zhuang Tang, Lu Yang, Qiang Wei, Fan Wang, Liang-Ren Liu, Ping Tan, Shi Qiu, Yu Fan
No abstract text is available yet for this article.
September 5, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28879865/proton-pump-inhibitor-use-does-not-affect-semen-quality-in-subfertile-men
#16
Sorena Keihani, James R Craig, Chong Zhang, Angela P Presson, Jeremy B Myers, William O Brant, Kenneth I Aston, Benjamin R Emery, Timothy G Jenkins, Douglas T Carrell, James M Hotaling
Proton-pump inhibitors (PPIs) are among the most widely used drugs worldwide. PPI use has recently been linked to adverse changes in semen quality in healthy men; however, the effects of PPI use on semen parameters remain largely unknown specifically in cases with male factor infertility. We examined whether PPI use was associated with detrimental effects on semen parameters in a large population of subfertile men. We retrospectively reviewed data from 12 257 subfertile men who had visited our fertility clinic from 2003 to 2013...
September 5, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28869220/microdissection-testicular-extraction-for-a-patient-with-transverse-testicular-ectopia-and-testicular-fusion
#17
LETTER
Chen Chen, Yi-Chun Wang, Ya-Min Wang, Chao Qin, Ning-Hong Song
No abstract text is available yet for this article.
September 1, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28869219/andrographolide-sensitizes-prostate-cancer-cells-to-trail-induced-apoptosis
#18
Ruo-Jing Wei, Xin-Shi Zhang, Da-Lin He
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising agent for anticancer therapy. The identification of small molecules that can establish the sensitivity of prostate cancer (PCa) cells to TRAIL-induced apoptosis is crucial for the targeted treatment of PCa. PC3, DU145, JAC-1, TsuPr1, and LNCaP cells were treated with Andrographolide (Andro) and TRAIL, and the apoptosis was measured using the Annexin V/PI double staining method. Real time-polymerase chain reaction (PCR) and Western blot analysis were performed to measure the expression levels of target molecules...
September 1, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28857053/a-rare-polypyrimidine-tract-mutation-in-the-androgen-receptor-gene-results-in-complete-androgen-insensitivity-syndrome
#19
LETTER
Shi-Min Yuan, Huan Huang, Chao-Feng Tu, Juan Du, Da-Bao Xu, Ge Lin, Guang-Xiu Lu, Yue-Qiu Tan
No abstract text is available yet for this article.
August 29, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28857052/antiarrhythmic-drug-usage-and-prostate-cancer-a-population-based-cohort-study
#20
Li-Ting Kao, Chung-Chien Huang, Herng-Ching Lin, Chao-Yuan Huang
Even though the relationship between antiarrhythmic drug usage and subsequent prostate cancer (PCa) risk has recently been highlighted, relevant findings in the previous literature are still inconsistent. In addition, very few studies have attempted to investigate the association between sodium channel blockers or potassium channel blockers for arrhythmia and the subsequent PCa risk. Therefore, this cohort study aimed to find the relationship between antiarrhythmic drug usage and the subsequent PCa risk using a population-based dataset...
August 29, 2017: Asian Journal of Andrology
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