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Asian Journal of Andrology

Xiao-Song Jiang, Huan-Jun Wang, Jin-Hua Lin, Yan Guo, Can-Hui Sun, Ling Lin, Jian Guan
No abstract text is available yet for this article.
July 11, 2017: Asian Journal of Andrology
Lucio Dell'Atti, Andrea B Galosi
The current literature does not support the usefulness of clinical markers on predicting which patients with atypical small acinar proliferation (ASAP) are more likely to progress to prostate cancer (PCa). Androgens have long been considered to be the potential risk factors for PCa. However, the role of testosterone is controversial. The present study aims to analyze the relationship between serum testosterone (TS) levels and the diagnosis of PCa after a first prostate biopsy in patients affected by ASAP. This retrospective study included 143 patients diagnosed with ASAP in an initial transrectal ultrasound-guided prostate biopsy for suspicious PCa according to the European Association of Urology guidelines...
July 11, 2017: Asian Journal of Andrology
Min Wu, Shu-Zhu Chen, Wei-Jing Ye, Yi-Dong Liu
No abstract text is available yet for this article.
July 4, 2017: Asian Journal of Andrology
Wei-Wei Zheng, Ge Song, Qi-Ling Wang, Shan-Wen Liu, Xiao-Li Zhu, Shun-Mei Deng, An Zhong, Yu-Mei Tan, Ying Tan
Sperm DNA damage is recognized as an important biomarker of male infertility. To investigate this, sperm DNA damage was assessed by the sperm chromatin dispersion (SCD) test in semen and motile spermatozoa harvested by combined density gradient centrifugation (DGC) and swim-up in 161 couples undergoing in vitro fertilization (IVF). Semen analysis and sperm DNA damage results were compared between couples who did or did not achieve pregnancy. The sperm DNA damage level was significantly different between the two groups (P < 0...
June 30, 2017: Asian Journal of Andrology
Catherine Elix, Sumanta K Pal, Jeremy O Jones
Despite great progress in the detection and treatment of prostate cancer, this disease remains an incredible health and economic burden. Although androgen receptor (AR) signaling plays a key role in the development and progression of prostate cancer, aberrations in other molecular pathways also contribute to the disease, making it essential to identify and develop drugs against novel targets, both for the prevention and treatment of prostate cancer. One promising target is the peroxisome proliferator-activated receptor gamma (PPARγ) protein...
June 9, 2017: Asian Journal of Andrology
Hua Xie, Xiao-Ling Lin, Song Zhang, Ling Yu, Xiao-Xi Li, Yi-Chen Huang, Yi-Qing Lyu, Hai-Tao Chen, Jianfeng Xu, Fang Chen
Previous genome-wide association studies have identified variants in the diacylglycerol kinase kappa (DGKK) gene associated with hypospadias in populations of European descent. However, no variants of DGKK were confirmed to be associated with hypospadias in a recent Han Chinese study population, likely due to the limited number of single-nucleotide polymorphisms (SNPs) included in the analysis. In this study, we aimed to address the inconsistent results and evaluate the association between DGKK and hypospadias in the Han Chinese population through a more comprehensive analysis of DGKK variants...
June 9, 2017: Asian Journal of Andrology
Zhao-Yan Feng, Xiang-De Min, Liang Wang, Ba-Sen Li, Zan Ke, Pei-Pei Zhang, Zhen Kang
No abstract text is available yet for this article.
May 30, 2017: Asian Journal of Andrology
Brendan J Nolan, Mathis Grossmann
No abstract text is available yet for this article.
May 26, 2017: Asian Journal of Andrology
Min Chul Cho, Jung Kwon Kim, Sang Hoon Song, Sung Yong Cho, Sang Wook Lee, Soo Woong Kim, Jae-Seung Paick
This study aimed to investigate perceived ejaculatory function/satisfaction before treatment for lower urinary tract symptoms (LUTS)/benign prostatic hyperplasia (BPH) and to identify associations between specific categories of ejaculatory dysfunctions (EjDs) and LUTS. A total of 1574 treatment-naïve men with LUTS/BPH were included in this study. All patients underwent routine evaluation for LUTS/BPH including the International Index of Erectile Function and a 5-item questionnaire developed to assess ejaculatory volume/force/pain/satisfaction/latency time...
May 2, 2017: Asian Journal of Andrology
Hong-Jie Chen, Dong-Hai Li, Jun Zhang
No abstract text is available yet for this article.
July 2017: Asian Journal of Andrology
Abdul S Ansari, Ayesha Badar, Krithika Balasubramanian, Nirmal K Lohiya
The study aimed to evaluate reversal of short- and long-term vas occlusion with reversible inhibition of sperm under guidance (RISUG) using dimethyl sulfoxide (DMSO) and sodium bicarbonate (NaHCO3) in male rabbits (Oryctolagus cuniculus). Animals were divided into seven groups containing five animals each. Fortnightly, semen analysis revealed that sperm concentration and output steadily declined after vas occlusion and complete azoospermia was attained at 30-60 days postinjection. Spermatozoa reappeared at 60-75 days of reversal and normozoospermia was noticed between 135 days and 150 days in the reversal groups...
July 2017: Asian Journal of Andrology
Shan-Wen Liu, Yuan Li, Li-Li Zou, Yu-Tao Guan, Shuang Peng, Li-Xin Zheng, Shun-Mei Deng, Lin-Yan Zhu, Li-Wei Wang, Li-Xin Chen
Human spermatozoa encounter an osmotic decrease from 330 to 290 mOsm l-1 when passing through the female reproductive tract. We aimed to evaluate the role of chloride channels in volume regulation and sperm motility from patients with asthenozoospermia. Spermatozoa were purified using Percoll density gradients. Sperm volume was measured as the forward scatter signal using flow cytometry. Sperm motility was analyzed using computer-aided sperm analysis (CASA). When transferred from an isotonic solution (330 mOsm l-1 ) to a hypotonic solution (290 mOsm l-1 ), cell volume was not changed in spermatozoa from normozoospermic men; but increased in those from asthenozoospermic samples...
July 2017: Asian Journal of Andrology
Zhong-Wei Jia, Kun Chang, Bo Dai, Yun-Yi Kong, Yue Wang, Yuan-Yuan Qu, Yi-Ping Zhu, Ding-Wei Ye
Several studies have evaluated the risk factors influencing biochemical recurrence (BCR) of prostate cancer in patients receiving salvage radiotherapy (SRT) for BCR after radical prostatectomy (RP), but the results remain conflicting. In this study, we performed a meta-analysis to resolve this conflict. We searched the following databases: PubMed, Embase, and Web of Science using the following terms in "All fields": "salvage radiation therapy," "salvage IMRT," "S-IMRT," "salvage radiotherapy," "SRT," "radical prostatectomy," "RP," "biochemical recurrence," "BCR," "biochemical relapse...
July 2017: Asian Journal of Andrology
Lucio Dell'Atti
No abstract text is available yet for this article.
July 2017: Asian Journal of Andrology
Sung Han Kim, Weon Seo Park, Bo Ram Park, Jungnam Joo, Jae Young Joung, Ho Kyung Seo, Jinsoo Chung, Kang Hyun Lee
Prostate cancer is the second most common male cancer, with half of all patients going on to develop metastases. To better identify patients at high risk for prostate cancer progression and reduce prostate cancer-related mortality, improved prognostic factors are required. In this study, we used immunohistochemistry (IHC) to determine the prognostic values of multiple tissue biomarkers in hormone-naοve prostatectomy specimens of prostate cancer. Using 510 prostatectomy specimens collected between 2002 and 2012, IHC analysis was performed for Cerb-2, Cyclin D1, VEGF, EGFR, Rb, PSCA, p53, Bcl-2, Cox-2, PMS2, and Ki-67 on formalin-fixed paraffin-embedded sections...
July 2017: Asian Journal of Andrology
Li-Ting Kao, Herng-Ching Lin, Shiu-Dong Chung, Chao-Yuan Huang
Prior studies suggested that the use of androgen deprivation therapy (ADT) in patients with prostate cancer (PC) might cause the impairment of cognitive function which is one of the common symptoms of dementia; however, the association between ADT and cognitive impairment still remains controversial. This retrospective cohort study aimed to investigate the relationship between ADT and subsequent risk of dementia using a population-based dataset. Data for this study were taken from the Taiwan (China)Longitudinal Health Insurance Database 2005...
July 2017: Asian Journal of Andrology
Shu-Yuan Liu, Chang-Jun Zhang, Hai-Ying Peng, Hao Sun, Ke-Qin Lin, Xiao-Qin Huang, Kai Huang, Jia-You Chu, Zhao-Qing Yang
Male infertility is a multifactorial syndrome encompassing a wide variety of disorders. In recent years, several genome-wide single-nucleotide polymorphism (SNP) association studies (GWAS) have been performed on azoospermia and/or oligozoospermia in different populations including two GWAS on nonobstructive azoospermia in China; however, the association of SNPs with idiopathic male infertility, especially asthenozoospermia and oligozoospermia, and their correlation with semen parameters are still not clear...
July 2017: Asian Journal of Andrology
Qing Yang, Zi-Lian Cui, Qin Wang, Xun-Bo Jin, Yong Zhao, Mu-Wen Wang, Wei Song, Hua-Wei Qu, Wei-Ting Kang
To determine whether PlncRNA-1 induces apoptosis in prostate cancer cells through the Her-2 pathway. The expression of PlncRNA-1, Her-2, and related cyclin proteins in 23 cases of prostate cancer and adjacent normal tissues was analyzed and compared. LNCaP cells were divided into a control group and an LNCaP-PlncRNA-1-siRNA experimental group. Normal prostate RWPE-1 cells were divided into an RWPE-1 control group and an RWPE-1-PlncRNA-1 experimental group. After PlncRNA-1 silencing and overexpression, changes in Her-2 and cyclinD1 expression levels were detected both in vivo and in vitro...
July 2017: Asian Journal of Andrology
Rebeca López-Úbeda, Francisco A García-Vázquez, Joaquín Gadea, Carmen Matás
The interaction of oviductal epithelial cells (OECs) with the spermatozoa has beneficial effects on the sperm functions. The aim of this study is to evaluate the in vitro fertilizing capacity of incubating spermatozoa previously selected by density gradient in OEC and determinate some sperm characteristics that could explain the results obtained. In this study, we assessed in vitro fertilization (IVF), tyrosine phosphorylation, phosphatidylserine translocation, nuclear DNA fragmentation, and chromatin decondensation...
July 2017: Asian Journal of Andrology
Bumsoo Park, Seol Ho Choo
Prostatic calculi are a common finding on transrectal prostate ultrasound. However, it remains unclear whether they are significantly associated with lower urinary tract symptoms (LUTS). Our objective was to evaluate the association between prostatic calculi and LUTS with a focus on "calculi burden" because no studies have investigated prostatic calculi using "calculi burden" as an indicator. A total of 606 participants who received transrectal prostate ultrasound were divided into two groups according to the presence of prostatic calculi...
July 2017: Asian Journal of Andrology
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