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Asian Journal of Andrology

Parviz K Kavoussi
The aim of this study was to validate the effectiveness of targeted microsurgical spermatic cord denervation (MSCD) of the trifecta nerve complex in comparison to traditional full MSCD with complete skeletonization of the spermatic cord in men with chronic orchialgia. Retrospective chart review was performed by a single fellowship-trained microsurgeon between 2011 and 2016. Patients had follow-ups at 6 weeks, 6 months, and 1 year postoperatively. Thirty-nine men with chronic orchialgia underwent full MSCD between 2011 and 2013...
November 9, 2018: Asian Journal of Andrology
Ping Tan, Ming Shi, Jie Chen, Hang Xu, Nan Xie, Huan Xu, Yong Jiang, Jian-Zhong Ai, Liang-Ren Liu, Lu Yang, Qiang Wei
Cystatin-C (Cys-C) has been reported as a valuable prognostic biomarker in various malignancies. However, its effect on upper tract urothelial carcinoma (UTUC) patients has not been investigated before. Thus, to explore the impact of Cys-C on survival outcomes in patients undergoing radical nephroureterectomy (RNU), a total of 538 patients with UTUC who underwent RNU between 2005 and 2014 in our center (West China Hospital, Chengdu, China) were included in this study. Kaplan-Meier method and Cox regression analyses were performed to assess the relationship between Cys-C and survival outcomes using SPSS version 22...
November 9, 2018: Asian Journal of Andrology
Mei-Li-Yang Wu, Cheng-Shuang Wang, Qi Xiao, Chao-Hua Peng, Tie-Ying Zeng
Pelvic floor muscle exercise (PFME) is the most common conservative management for urinary incontinence (UI) after radical prostatectomy (RP). However, whether the PFME guided by a therapist (G-PFME) can contribute to the recovery of urinary continence for patients after RP is still controversial. We performed this meta-analysis to investigate the effectiveness of G-PFME on UI after RP and to explore whether the additional preoperative G-PFME is superior to postoperative G-PFME alone. Literature search was conducted on Cochrane Library, Embase, Web of Science, and PubMed, to obtain all relevant randomized controlled trials published before March 1, 2018...
November 2, 2018: Asian Journal of Andrology
Jian-Lin Hu, Hui-Xing Chen, Hui-Rong Chen, Yu Wu, Xiao-Wen Sun, Zheng Li, Jin-Fang Xing
Structural alterations in fibroelastic components of the penile corpus cavernousum (CC) may impair its compliance, resulting in venous leakage and erectile dysfunction (ED). Our study evaluated the effectiveness of noninvasive two-dimensional shear-wave elastography (2-D SWE) in quantifying penile CC lesions in rabbits with hyperlipidemia-induced ED. A total of 12 New Zealand white rabbits were randomly divided into two groups. Six were fed a high-cholesterol diet containing 2% cholesterol and 8.5% lard for 10 weeks and the other six were fed normal diet as controls...
November 2, 2018: Asian Journal of Andrology
Hui-Yu Xu, Hong-Xian Zhang, Zhen Xiao, Jie Qiao, Rong Li
Anti-Müllerian hormone (AMH) is a functional marker of fetal Sertoli cells. The germ cell number in adults depends on the number of Sertoli cells produced during perinatal development. Recently, AMH has received increasing attention in research of disorders related to male fertility. This paper reviews and summarizes the articles on the regulation of AMH in males and the serum levels of AMH in male fertility-related disorders. We have determined that follicle-stimulating hormone (FSH) promotes AMH transcription in the absence of androgen signaling...
October 26, 2018: Asian Journal of Andrology
Yi Liu, Wei Wang, Xiu-Bo Qin, Hui-Hui Wang, Ge Gao, Xiao-Dong Zhang, Xiao-Ying Wang
We aimed to evaluate the feasibility of simultaneous image acquisition of multiple instantaneous switchable scan (MISS) for prostate magnetic resonance imaging (MRI) on 3T. Fifty-three patients were scanned with MRI due to suspected prostate cancer. Twenty-eight of them got histological results. First, two readers assessed the structure delineation and image quality based on images of conventional T2-weighted imaging (T2WI) and diffusion-weighted imaging (DWI) (CTD). Second, two readers identified the index lesion together, and then, reader one evaluated the contrast of index lesion on T2WI and signal ratio on apparent diffusion coefficient map...
October 26, 2018: Asian Journal of Andrology
Cailey Guercio, Dattatraya Patil, Akanksha Mehta
We aimed to identify demographic and clinical predictors of varicocele repair in a contemporary cohort of men in the USA. We queried the 2009-2015 MarketScan Database using relevant ICD9, ICD10, and CPT codes to identify all 18-45 year olds with varicoceles. Differences in age, area of residence, clinical characteristics, and medical management between men who did and did not undergo varicocelectomy (open, laparoscopic, or microsurgical) during the study period were compared using unpaired t-tests and Chi-squared tests for continuous and categorical variables, respectively...
October 26, 2018: Asian Journal of Andrology
Luna Samanta, Rakesh Sharma, Zhihong Cui, Ashok Agarwal
Dysfunctional sperm maturation is the primary reason for the poor sperm motility and morphology in infertile men. Spermatozoa from infertile men were fractioned on three-layer density gradient (80%, 60%, and 40%). Fraction 1 (F1) refers to the least mature stage having the lowest density, whereas the fraction 4 (F4) includes the most dense and morphologically mature motile spermatozoa. Fraction 2 (F2) and fraction 3 (F3) represent the intermediate stages. Proteins were extracted and separated by 1-dimensional gel...
October 26, 2018: Asian Journal of Andrology
Yong-Liang Shang, Fu-Xi Zhu, Jie Yan, Liang Chen, Wen-Hao Tang, Sai Xiao, Wei-Ke Mo, Zhi-Guo Zhang, Xiao-Jin He, Jie Qiao, Yun-Xia Cao, Wei Li
Globozoospermia has been reported to be a rare but severe causation of male infertility, which results from the failure of acrosome biogenesis and sperm head shaping. Variants of dpy-19-like 2 (DPY19L2) are highly related to globozoospermia, but related investigations have been mainly performed in patients from Western countries. Here, we performed a screening of DPY19L2 variants in a cohort of Chinese globozoospermic patients and found that five of nine patients carried DPY19L2 deletions and the other four patients contained novel DPY19L2 point mutations, as revealed by whole-exome sequencing...
October 16, 2018: Asian Journal of Andrology
Bang-Jin Kim, Yong-Hee Kim, Myeong-Geun Oh, Ki-Jung Kim, Sang-Eun Jung, Ju-Hee Jin, Sun-Uk Kim, Kwan-Sik Min, Buom-Yong Ryu
Spermatogonial stem cells (SSCs) transmit genetic information to the next progeny in males. Thus, SSCs are a potential target for germline modifications to generate transgenic animals. In this study, we report a technique for the generation of transgenic rats by in vivo manipulation of SSCs with a high success rate. SSCs in juvenile rats were transduced in vivo with high titers of lentivirus harboring enhanced green fluorescent protein and mated with wild-type females to create founder rats. These founder rats expressed the transgene and passed on the transgene with an overall success rate of 50...
October 12, 2018: Asian Journal of Andrology
Jae Won Lee, Dong-Hun Lee, Jae Keun Park, Jin Soo Han
Testicular torsion, a common urologic emergency, is primarily caused by ischemia/reperfusion (I/R) injury of the testis. Nitric oxide (NO)-derived from nitrite (NO2 - ) has been reported to have prominent therapeutic effects on I/R injury in the heart, liver, and brain; however, its effects on testicular I/R injury have not been evaluated. This study, therefore, investigated whether NO from NO2 - is beneficial in a rat model of testicular I/R injury which eventually results in impaired spermatogenesis. Male Sprague-Dawley rats were assigned to the following seven groups: group A, sham-operated control group; Group B, I/R with no treatment; Groups C, D, and E, I/R followed by treatment with three different doses of NO2 - ; Group F, I/R followed by administration of NO2 - and NO scavenger (2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide potassium salt [C-PTIO]); and Group G, I/R followed by administration of nitrate (NO3 - )...
October 12, 2018: Asian Journal of Andrology
Jared J Wallen, SriGita K Madiraju, Run Wang, Gerard D Henry
No abstract text is available yet for this article.
September 25, 2018: Asian Journal of Andrology
Shathmigha Ketheeswaran, Thor Haahr, Betina Povlsen, Rita Laursen, Birgit Alsbjerg, Helle Elbaek, Sandro C Esteves, Peter Humaidan
No abstract text is available yet for this article.
September 18, 2018: Asian Journal of Andrology
Zhi-Hua Wan, Yuan-Jie Zhang, Lin Chen, Yong-Lian Guo, Guo-Hao Li, Ding Wu, Yong Wang
Type 2 diabetes mellitus (T2DM) is a common cause of erectile dysfunction (ED). It has been demonstrated that G protein-coupled receptor kinase 2 (GRK2) overexpression contributes to diabetic endothelial dysfunction and oxidative stress, which also underlies ED in T2DM. We hypothesized that GRK2 overexpressed and attenuated endothelial function of the cavernosal tissue in a rat model of T2DM. T2DM rats were established by feeding with a high-fat diet (HFD) for 2 weeks and then administering two intraperitoneal (IP) injections of a low dose of streptozotocin (STZ), followed by continuous feeding with a HFD for 6 weeks...
September 14, 2018: Asian Journal of Andrology
Xue-Sheng Wang, Li-Qiang Guo, Zhi-Ying Xiao, Yong Guan, Jian-Ye Zhang, Ming Li, Zhen Ma, Zhi-He Xu, Guo-Mei Ye, Ming-Zhen Yuan
The aim of our study was to investigate the role of platelet parameters including mean platelet volume (MPV) and platelet count (PC) in the pathogenesis of penile arteriogenic erectile dysfunction (ED) and to evaluate the association between the platelet parameters and arteriogenic ED. There were 244 patients with ED (based on the International Index of Erectile Function [IIEF]-5 ≤21) and 60 healthy controls (IIEF-5 >21) enrolled. All participants were asked to undergo a laboratory examination, and penile vascular function was evaluated using penile color Doppler ultrasonography (pDUS)...
September 7, 2018: Asian Journal of Andrology
Li-Ning Jiang, Ya-Bin Liu, Bing-Hui Li
Lycopene is a natural compound that alleviates oxidative stress and inflammation, exerting therapeutic effects in a number of cancers. The aim of this study is to investigate the efficacy of lycopene in inhibiting prostate cancer. Cell viability assays indicated the dose- and time-dependent toxicity of lycopene in prostate cancer cells. Annexin V/propidium iodide double-staining assays revealed the strong apoptotic effects of lycopene. The levels of inflammatory factors, including interleukin-1 (IL1), IL6, IL8, and tumor necrosis factor-α (TNF-α), in lycopene-treated cells were also reduced by lycopene treatment...
September 7, 2018: Asian Journal of Andrology
Fabiana A de Oliveira, Waldemar S Costa, Francisco J B Sampaio, Bianca M Gregorio
High-fat diets affect male reproduction and sexual function. Therefore, we evaluated the effects of prolonged resveratrol administration on the metabolic, sperm, and testicular parameters of rats fed a cafeteria diet. Male Wistar rats were divided at weaning into control (C, n = 20) and cafeteria (CAF, n = 16) groups. At 3 months, half of them were given daily supplementations of resveratrol (C-R, n = 10; CAF-R, n = 8) at a dosage of 30 mg kg-1 body mass for 2 months. Animals were killed at 5 months of age, and blood, spermatozoa, and testes were collected for further analysis...
September 7, 2018: Asian Journal of Andrology
Cong Shen, Jun Yu, Xi Zhang, Chen-Chen Liu, Yue-Shuai Guo, Jia-Wei Zhu, Ke Zhang, Yi Yu, Ting-Ting Gao, Shen-Min Yang, Hong Li, Bo Zheng, Xiao-Yan Huang
While it is known that spermatogonial stem cells (SSCs) initiate the production of male germ cells, the mechanisms of SSC self-renewal, proliferation, and differentiation remain poorly understood. We have previously identified Strawberry Notch 1 (SBNO1), a vertebrate strawberry notch family protein, in the proteome profile for mouse SSC maturation and differentiation, revealing SBNO1 is associated with neonatal testicular development. To explore further the location and function of SBNO1 in the testes, we performed Sbno1 gene knockdown in mice to study the effects of SBNO1 on neonatal testicular and SSC development...
September 7, 2018: Asian Journal of Andrology
Ho-Fai Wong, Chi-Hang Yee, Jeremy Y C Teoh, Samson Y S Chan, Peter K F Chiu, Ho-Yuen Cheung, Simon S M Hou, Chi Fai Ng
No abstract text is available yet for this article.
September 4, 2018: Asian Journal of Andrology
Chun-Jung Lin, U-Ging Lo, Jer-Tsong Hsieh
Prostate cancer (PCa) is the most common cause of malignancy in males and the third leading cause of cancer mortality in the United States. The standard care for primary PCa with local invasive disease mainly is surgery and radiation. For patients with distant metastases, androgen deprivation therapy (ADT) is a gold standard. Regardless of a favorable outcome of ADT, patients inevitably relapse to an end-stage castration-resistant prostate cancer (CRPC) leading to mortality. Therefore, revealing the mechanism and identifying cellular components driving aggressive PCa is critical for prognosis and therapeutic intervention...
September 4, 2018: Asian Journal of Andrology
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