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Asian Journal of Andrology

Han Wu, Wen-Hao Tang, Lian-Ming Zhao, De-Feng Liu, Yu-Zhuo Yang, Hai-Tao Zhang, Zhe Zhang, Kai Hong, Hao-Cheng Lin, Hui Jiang
Stem cell therapy is a potentially promising option for erectile dysfunction; however, its risk of tumorigenicity is a clinical hurdle and the risk is positively related to the number of injected cells. Our previous study showed that nanotechnology improved adipose-derived stem cell (ADSC) therapy for erectile dysfunction of cavernous nerve injury (CNI) by attracting cells in the corpus cavernosum. These results indicated the possibility of using a reduced dosage of ADSCs for intracavernous injection. In this exploratory study, we used lower dosage (2 × 105 cells) of ADSCs for intracavernous injection (ICI) and the nanotechnology approach...
July 10, 2018: Asian Journal of Andrology
Hui Jiang, Lian-Ming Zhao, Hao-Cheng Lin, Su Yan, Ji-Hong Liu, Zhao-Hui Zhu, Jin-Dan Luo, Yu-Tian Dai, Fu-Biao Li, Ying Lou, Zhi-Chao Zhang
Once-daily tadalafil administration has been well established; however, studies about tadalafil once-daily treatment in the Chinese population are lacking. In this phase 4, postmarketing study, we ascertained the long-term safety and effectiveness of tadalafil 2.5 mg and 5.0 mg once daily in Chinese men with erectile dysfunction (n = 635). The primary endpoint of the study was safety at 12 months as assessed by the proportion of patients experiencing at least one treatment-emergent adverse event (serious or nonserious)...
July 10, 2018: Asian Journal of Andrology
María Molina-Vega, Araceli Muñoz-Garach, Miguel Damas-Fuentes, José Carlos Fernández-García, Francisco J Tinahones
Male hypogonadism associated with obesity is a very prevalent condition and is increasing in parallel with the epidemic prevalence of obesity. Low testosterone levels promote higher fat mass with reduced lean mass. Male hypogonadism is related to an increase in associated cardiometabolic complications, such as hypertension, type 2 diabetes mellitus, the metabolic syndrome, and cardiovascular disease. Its influence as a comorbidity of obesity is becoming more evident and should be evaluated and treated in at-risk patients...
July 3, 2018: Asian Journal of Andrology
Antonio Luigi Pastore, Giovanni Palleschi, Andrea Fuschi, Yazan Al Salhi, Alessandro Zucchi, Giorgio Bozzini, Ester Illiano, Elisabetta Costantini, Antonio Carbone
The aim of the study was to evaluate the long-term outcomes of pelvic floor muscle (PFM) rehabilitation in males with lifelong premature ejaculation (PE), using intravaginal ejaculatory latency time (IELT) and the self-report Premature Ejaculation Diagnostic Tool (PEDT) as primary outcomes. A total of 154 participants were retrospectively reviewed in this study, with 122 completing the training protocol. At baseline, all participants had an IELT ≤60 s and PEDT score >11. Participants completed a 12-week program of PFM rehabilitation, including physio-kinesiotherapy treatment, electrostimulation, and biofeedback, with three sessions per week, with 20 min for each component completed at each session...
July 3, 2018: Asian Journal of Andrology
Kun-Long Lyu, Jin-Tao Zhuang, Philip S Li, Yong Gao, Liang Zhao, Ya-Dong Zhang, Ming-Kuan Zhou, Jing-Wei Yu, Xin Feng, Xiang-Zhou Sun, Chun-Hua Deng, Xiang-An Tu
Microsurgical longitudinal intussusception vasoepididymostomy (LIVE) has been widely used to treat epididymal obstructive azoospermia since 2004. Although the deferential vasculature plays an important role in supplying blood to the testis and epididymis, little attention has been paid to the potential benefits of sparing the deferential vessels during the anastomosis in LIVE. This study aimed to evaluate the efficacy and safety of deferential vessel-sparing LIVE in humans. From December 2013 to December 2015, 69 azoospermic men with epididymal obstruction due to a genital infection, trauma, or idiopathic factors underwent deferential vessel-sparing LIVE in the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China...
June 29, 2018: Asian Journal of Andrology
Yun-Fai Chris Lau, Yunmin Li, Tatsuo Kido
The Y-located testis-specific protein Y-encoded (TSPY) and its X-homologue TSPX originated from the same ancestral gene, but act as a proto-oncogene and a tumor suppressor gene, respectively. TSPY has specialized in male-specific functions, while TSPX has assumed the functions of the ancestral gene. Both TSPY and TSPX harbor a conserved SET/NAP domain, but are divergent at flanking structures. Specifically, TSPX contains a C-terminal acidic domain, absent in TSPY. They possess contrasting properties, in which TSPY and TSPX, respectively, accelerate and arrest cell proliferation, stimulate and inhibit cyclin B-CDK1 phosphorylation activities, have no effect and promote proteosomal degradation of the viral HBx oncoprotein, and exacerbate and repress androgen receptor (AR) and constitutively active AR variant, such as AR-V7, gene transactivation...
June 29, 2018: Asian Journal of Andrology
Carla Mayans, Joan Blanco, Oliver Valero, Francesca Vidal, Zaida Sarrate
No abstract text is available yet for this article.
June 26, 2018: Asian Journal of Andrology
Arcangelo Barbonetti, Settimio D'Andrea, Alessio Martorella, Giorgio Felzani, Sandro Francavilla, Felice Francavilla
A lower risk of prostate cancer has been reported in men with spinal cord injury (SCI) as compared to that observed in able-bodied subjects. As injury-related consequences can have opposite effects on prostate pathophysiology, this meta-analysis aimed to (1) establish the existence/quantify the extent of decreased prostate cancer risk following SCI and (2) find out if there is any statistically significant difference in prostate-specific antigen (PSA) levels between SCI and able-bodied subjects. MEDLINE, Cochrane Library, Scopus, CINAHL, and ScienceDirect databases were used...
June 26, 2018: Asian Journal of Andrology
Pamela Uribe, María E Cabrillana, Miguel W Fornés, Favián Treulen, Rodrigo Boguen, Vladimir Isachenko, Evgenia Isachenko, Raúl Sánchez, Juana V Villegas
Peroxynitrite is a highly reactive nitrogen species and a potent inducer of apoptosis and necrosis in somatic cells. Peroxynitrite-induced nitrosative stress has emerged as a major cause of impaired sperm function; however, its ability to trigger cell death has not been described in human spermatozoa. The objective here was to characterize biochemical and morphological features of cell death induced by peroxynitrite-mediated nitrosative stress in human spermatozoa. For this, spermatozoa were incubated with and without (untreated control) 3-morpholinosydnonimine (SIN-1), in order to generate peroxynitrite...
June 22, 2018: Asian Journal of Andrology
Ying Zhang, Li-Na Wang, Ya-Ni Lin, Yuan-Xin Xing, Yu Shi, Jian Zhao, Wei-Wen Chen, Bo Han
We sought to investigate the underlying mechanism of action of the long noncoding RNA (lncRNA) LOC283070 in the development of androgen independence in prostate cancer. The interactions between LOC283070 and target proteins were investigated by RNA pull-down and RNA-binding protein immunoprecipitation (RIP) assays. Subcellular fractionation and quantitative reverse transcription-polymerase chain reaction (qRT-PCR) were used to detect the subcellular localization of LOC283070. Western blotting was performed to detect the expression of prohibitin 2 (PHB2)...
June 19, 2018: Asian Journal of Andrology
Alexandra M Blee, Haojie Huang
Therapy resistance is a significant challenge for prostate cancer treatment in clinic. Although targeted therapies such as androgen deprivation and androgen receptor (AR) inhibition are effective initially, tumor cells eventually evade these strategies through multiple mechanisms. Lineage reprogramming in response to hormone therapy represents a key mechanism that is increasingly observed. The studies in this area have revealed specific combinations of alterations present in adenocarcinomas that provide cells with the ability to transdifferentiate and perpetuate AR-independent tumor growth after androgen-based therapies...
June 12, 2018: Asian Journal of Andrology
Shanshan Bai, Bryan Y Zhang, Yan Dong
The development and progression of metastatic castration-resistant prostate cancer is the major challenge in the treatment of advanced prostate cancer. The androgen receptor signaling pathway remains active in metastatic castration-resistant prostate cancer. Docetaxel and cabazitaxel are the first- and second-line chemotherapy, respectively, for patients with metastatic castration-resistant prostate cancer. These two taxanes, in general, function by (i) inhibiting mitosis and inducing apoptosis and (ii) preventing microtubule-dependent cargo trafficking...
June 12, 2018: Asian Journal of Andrology
Marcello H A Da Silva, Waldemar S Costa, Francisco J B Sampaio, Diogo B De Souza
Erectile dysfunction is a common side effect of finasteride and dutasteride treatments. The objective of this study was to investigate the structural changes in the penis using a benign prostatic hyperplasia (BPH) rodent model treated with dutasteride or finasteride. Sixty male rats were divided into the following groups: C, untreated control rats; C + D, control rats receiving dutasteride; C + F, control rats receiving finasteride; H, untreated spontaneously hypertensive rats (SHRs); H + D, SHRs treated with dutasteride; and H + F, SHRs treated with finasteride...
June 8, 2018: Asian Journal of Andrology
Marta Gianzo, Itziar Urizar-Arenaza, Iraia Muñoa-Hoyos, Zaloa Larreategui, Nicolás Garrido, Luis Casis, Jon Irazusta, Nerea Subirán
Angiotensin-converting enzyme functions in the male reproductive system, but the extent of its function in reproduction is not fully understood. The primary objective of this work was to investigate the relationship between the testicular isoform of angiotensin-converting enzyme present in human spermatozoa and semen parameters, human embryo quality, and assisted reproduction success. A total of 81 semen samples and 635 embryos from couples undergoing oocyte donation cycles at the IVI Bilbao Clinic were analyzed...
June 5, 2018: Asian Journal of Andrology
Qipeng Liu, Qiaqia Li, Sen Zhu, Yang Yi, Qi Cao
B lymphoma Moloney murine leukemia virus insertion region 1 (BMI1), a core member of polycomb repressive complex 1 (PRC1), has been intensely investigated in the field of cancer epigenetics for decades. Widely known as a critical regulator in cellular physiology, BMI1 is essential in self-renewal and differentiation in different lineages of stem cells. BMI1 also plays a significant role in cancer etiology for its involvement in pathological progress such as epithelial-mesenchymal transition (EMT) and cancer stem cell maintenance, propagation, and differentiation...
June 1, 2018: Asian Journal of Andrology
Miroslav L Djordjevic, Uros Bumbasirevic, Borko Stojanovic, Tamara Kravic Stevovic, Tamara Martinovic, Marta Bizic, Vladimir Kojovic
Autologous tissue engineering using biodegradable scaffolds as a carrier is a well-known procedure for penile girth enhancement. We evaluated a group of previously treated patients with the aim to analyze histomorphometric changes after tissue remodeling and to estimate the benefits of repeated procedure. Between February 2012 and December 2016, a group of 21 patients, aged 22-37 (mean 28.0) years, underwent a repeated penile girth enhancement procedure with biodegradable scaffolds. Procedure included insertion of two poly-lactic-co-glycolic acid scaffolds seeded with laboratory-prepared fibroblasts from scrotal tissue specimens...
June 1, 2018: Asian Journal of Andrology
Ryo Oka, Takanobu Utsumi, Takumi Endo, Masashi Yano, Shuichi Kamijima, Naoto Kamiya, Hiroyoshi Suzuki
No abstract text is available yet for this article.
June 1, 2018: Asian Journal of Andrology
Yicheng Zhao, Wenliang Li
Prostate cancer is a complex, heterogeneous disease that mainly affects the older male population with a high-mortality rate. The mechanisms underlying prostate cancer progression are still incompletely understood. Beta-adrenergic signaling has been shown to regulate multiple cellular processes as a mediator of chronic stress. Recently, beta-adrenergic signaling has been reported to affect the development of aggressive prostate cancer by regulating neuroendocrine differentiation, angiogenesis, and metastasis...
May 29, 2018: Asian Journal of Andrology
Hai-Tao Ma, Chang-Min Niu, Jing Xia, Xue-Yi Shen, Meng-Meng Xia, Yan-Qiu Hu, Ying Zheng
To clarify the functions and mechanism of stimulated by retinoic acid gene 8 (Stra8) in spermatogenesis, we analyzed the testes from Stra8 knockout and wild-type mice during the first wave of spermatogenesis. Comparisons showed no significant differences in morphology and number of germ cells at 11 days postpartum, while 21 differentially expressed genes (DEGs) associated with spermatogenesis were identified. We speculate that Stra8 performs many functions in different phases of spermatogenesis, such as establishment of spermatogonial stem cells, spermatogonial proliferation and self-renewal, spermatogonial differentiation and meiosis, through direct or indirect regulation of these DEGs...
May 29, 2018: Asian Journal of Andrology
Shu-Ping Li, Li-Wei Li, Ming-Xia Sun, Xin-Xin Chen, Xiu-Feng Wang, Zeng-Kui Li, Sheng-Yun Zhou, Dong-Cai Zhai, Shu-Xia Geng, Shu-Jun Li, Xiao-Wei Dou
No abstract text is available yet for this article.
May 25, 2018: Asian Journal of Andrology
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