journal
MENU ▼
Read by QxMD icon Read
search

Asian Journal of Andrology

journal
https://www.readbyqxmd.com/read/29735818/treatment-strategy-for-metastatic-prostate-cancer-with-extremely-high-psa-level-reconsidering-the-value-of-vintage-therapy
#1
Yasutaka Yamada, Shinichi Sakamoto, Yoshiyasu Amiya, Makoto Sasaki, Takayuki Shima, Akira Komiya, Noriyuki Suzuki, Koichiro Akakura, Tomohiko Ichikawa, Hiroomi Nakatsu
The prognostic significance of initial prostate-specific antigen (PSA) level for metastatic prostate cancer remains uncertain. We investigated the differences in prognosis and response to hormonal therapies of metastatic prostate cancer patients according to initial PSA levels. We analyzed 184 patients diagnosed with metastatic prostate cancer and divided them into three PSA level groups as follows: low (<100 ng ml-1 ), intermediate (100-999 ng ml-1 ), and high (≥1000 ng ml-1 ). All patients received androgen deprivation therapy (ADT) immediately...
May 4, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29735817/-gata4-mutations-are-uncommon-in-patients-with-46-xy-disorders-of-sex-development-without-heart-anomaly
#2
LETTER
Maki Igarashi, Kentaro Mizuno, Masafumi Kon, Satoshi Narumi, Yoshiyuki Kojima, Yutaro Hayashi, Tsutomu Ogata, Maki Fukami
No abstract text is available yet for this article.
May 4, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29735816/transurethral-seminal-vesiculoscopy-for-recurrent-hemospermia-experience-from-419-cases
#3
Rui Chen, Lei Wang, Xia Sheng, Shu-Guang Piao, Xin-Wen Nian, Xin Cheng, Tie Zhou, Hui-Zhen Li, Ya-Wei Liu, Guang-Hua Chen, Chun-Lei Zhang, De-Pei Kong, Guang-An Xiao, Xin Lu, Zhen-Yu Jia, Zhi-Yong Liu, Ying-Hao Sun
We summarized our experience in transurethral seminal vesiculoscopy (TSV) for recurrent hemospermia by introducing surgical techniques, intraoperative findings, and treatment outcomes. TSV was performed in 419 patients with an initial diagnosis of persistent hemospermia at Shanghai Changhai Hospital (Shanghai, China) from May 2007 to November 2015. TSV was successfully performed in 381 cases (90.9%). Hemospermia was alleviated or disappeared in 324 (85.0%) patients by 3 months after surgery. Common intraoperative manifestations were bleeding, obstruction or stenosis, mucosal lesions, and calculus...
April 27, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29697066/results-of-intrauterine-inseminations-with-two-pooled-sequential-ejaculates-in-cases-of-oligozoospermia
#4
LETTER
Jessika Moreau, Nicolas Gatimel, Jean Parinaud, Roger Leandri
No abstract text is available yet for this article.
April 24, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29676291/pancreatic-kininogenase-improves-erectile-function-in-streptozotocin-induced-type-2-diabetic-rats-with-erectile-dysfunction
#5
Guo-Tao Chen, Bai-Bing Yang, Jian-Huai Chen, Zheng Zhang, Lei-Lei Zhu, He-Song Jiang, Wen Yu, Yun Chen, Yu-Tian Dai
Erectile dysfunction (ED) associated with type 2 diabetes is a severe problem that requires effective treatment. Pancreatic kininogenase (PK) has the potential to improve the erectile function of ED patients. This study aims to investigate the effect of PK on erectile function in streptozotocin-induced type 2 diabetic ED rats. To achieve this goal, we divided male Sprague-Dawley rats into five groups. One group was not treated, and the other four groups were treated with saline, sildenafil, PK or sildenafil, and PK, respectively, for 4 weeks after the induction of type 2 diabetic ED...
April 20, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29676290/increased-expression-of-pelp1-in-human-sperm-is-correlated-with-decreased-semen-quality
#6
Izabela Skibinska, Miroslaw Andrusiewicz, Michal Soin, Magdalena Jendraszak, Paulina Urbaniak, Piotr Jedrzejczak, Malgorzata Kotwicka
Proline-, glutamic acid-, and leucine-rich protein 1 (PELP1) is a scaffolding protein involved in both genomic and nongenomic estrogen signal transduction pathways. To date, the role of PELP1 protein has yet to be characterized in human sperm and has not been associated with sperm parameters. To confirm the presence of PELP1 in human sperm, fresh semen samples were obtained from 178 donors. The study was designed to establish both mRNA and protein presence, and protein cellular localization. Additionally, the number of PELP1-positive spermatozoa was analyzed in men with normal and abnormal semen parameters...
April 20, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29667617/combination-of-stromal-vascular-fraction-and-ad-comp-ang1-gene-therapy-improves-long-term-therapeutic-efficacy-for-diabetes-induced-erectile-dysfunction
#7
Guo-Nan Yin, Lin Wang, Xiang-Nan Lin, Lei Shi, Zhen-Lin Gao, Feng-Chan Han, Ping Li, Yin-Chuan Jin, Jun-Kyu Suh, Ji-Kan Ryu, Xiong Wang, Hai-Rong Jin
Men with diabetic erectile dysfunction (ED) respond poorly to the currently available oral phosphodiesterase-5 inhibitors. Therefore, functional therapies for diabetic ED are needed. Stromal vascular fraction (SVF) and the adenovirus-mediated cartilage oligomeric matrix angiopoietin-1 (Ad-COMP-Ang1) gene are known to play critical roles in penile erection. We previously reported that SVF and Ad-COMP-Ang1 have only a short-term effect in restoring erectile function. Further improvements to ED therapy are needed for long-lasting effects...
April 17, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29667616/using-the-prostate-imaging-reporting-and-data-system-version-2-pi-rids-v2-to-detect-prostate-cancer-can-prevent-unnecessary-biopsies-and-invasive-treatment
#8
Chang Liu, Shi-Liang Liu, Zhi-Xian Wang, Kai Yu, Chun-Xiang Feng, Zan Ke, Liang Wang, Xiao-Yong Zeng
Prostate cancer (PCa) is one of the most common cancers among men globally. The authors aimed to evaluate the ability of the Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) to classify men with PCa, clinically significant PCa (CSPCa), or no PCa, especially among those with serum total prostate-specific antigen (tPSA) levels in the "gray zone" (4-10 ng ml-1 ). A total of 308 patients (355 lesions) were enrolled in this study. Diagnostic efficiency was determined. Univariate and multivariate analyses, receiver operating characteristic curve analysis, and decision curve analysis were performed to determine and compare the predictors of PCa and CSPCa...
April 13, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29667615/vitamin-d-in-prostate-cancer
#9
REVIEW
Donald L Trump, Jeanny B Aragon-Ching
Signaling through the vitamin D receptor has been shown to be biologically active and important in a number of preclinical studies in prostate and other cancers. Epidemiologic data also indicate that vitamin D signaling may be important in the cause and prognosis of prostate and other cancers. These data indicate that perturbation of vitamin D signaling may be a target for the prevention and treatment of prostate cancer. Large studies of vitamin D supplementation will be required to determine whether these observations can be translated into prevention strategies...
April 13, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29623908/the-risk-of-human-papillomavirus-infection-for-male-fertility-abnormality-a-meta-analysis
#10
Yi-Quan Xiong, Yan-Xia Chen, Ming-Ji Cheng, Wen-Qiao He, Qing Chen
Human papillomavirus (HPV) is the most common sexually transmitted virus in males and females worldwide; yet its impact upon male fertility remains unclear. The objective of this study was to evaluate the potential impact of HPV infection in semen on male fertility abnormality. A systematic literature search was performed in PubMed, Medline, Embase, Web of Science, and the Cochrane Library database for relevant publications up to May 6, 2017. The odds ratio (OR), and its corresponding 95% confidence interval (CI), was selected to represent the effect size...
April 3, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29623907/recurrent-paratesticular-dedifferentiated-liposarcoma-after-contralateral-radical-orchiectomy
#11
LETTER
Jin Wang, Yi-Peng Du, Sheng-Xian Li, Jing-Hai Hu, Chun-Xi Wang
No abstract text is available yet for this article.
April 3, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29600796/rapid-screening-for-klinefelter-syndrome-with-a-simple-high-resolution-melting-assay-a-multicenter-study
#12
Dong-Mei Fu, Yu-Lin Zhou, Jing Zhao, Ping Hu, Zheng-Feng Xu, Shi-Ming Lv, Jun-Jie Hu, Zhong-Min Xia, Qi-Wei Guo
Klinefelter syndrome (KS) is the set of symptoms that result from the presence of an extra X chromosome in males. Postnatal population-based KS screening will enable timely diagnosis of this common chromosomal disease, providing the opportunity for early intervention and therapy at the time point when they are most effective and may prevent later symptoms or complications. Therefore, through this study, we introduced a simple high-resolution melting (HRM) assay for KS screening and evaluated its clinical sensitivity and specificity in three medical centers using 1373 clinical blood samples...
March 30, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29600795/no-effect-of-abstinence-time-on-nerve-electrophysiological-test-in-premature-ejaculation-patients
#13
Bai-Bing Yang, Jia-Dong Xia, Zhi-Wei Hong, Zheng Zhang, You-Feng Han, Yun Chen, Yu-Tian Dai
The nerve electrophysiological tests may differentiate the treatment of primary premature ejaculation (PPE) in our previous studies. However, no study verifies if the results will be affected by abstinence time. From January to December in 2016, fifty PPE patients ejaculated within 2 min and 28 control subjects were enrolled. The nerve electrophysiological tests, including dorsal nerve somatosensory evoked potential (DNSEP), glans penis somatosensory evoked potential (GPSEP), and penile sympathetic skin response (PSSR), were recorded before and immediately after ejaculation...
March 30, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29582792/perspectives-on-the-clinical-development-of-immunotherapy-in-prostate-cancer
#14
Lisa M Cordes, James L Gulley, Ravi A Madan
Despite impressive survival benefits with immunotherapy in patients with various solid tumors, the full potential of these agents in prostate cancer has yet to be realized. Sipuleucel-T demonstrated a survival benefit in this population, indicating that prostate cancer is an immunoresponsive disease; however, these results have not been matched by other agents. A large trial with ipilimumab in prostate cancer failed to meet its primary objective, and small trials with PD-1/PD-L1 inhibitors did not yield a significant improvement in overall response...
March 27, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29578116/seminal-plasma-mir-192a-a-biomarker-predicting-successful-resolution-of-nonobstructive-azoospermia-following-varicocele-repair
#15
Er-Lei Zhi, Guo-Qing Liang, Peng Li, Hui-Xing Chen, Ru-Hui Tian, Peng Xu, Zheng Li
This study was performed to investigate a potential marker for the presence of spermatozoa in the ejaculate following varicocelectomy in Chinese men with nonobstructive azoospermia and varicoceles. The micro-RNA (miR)-192a levels in seminal plasma and testicular tissue were evaluated by quantitative real-time polymerase chain reaction from 60 men with nonobstructive azoospermia and varicoceles (Group A: 27 men with spermatozoa found in the ejaculate after surgery; Group B: 33 men without spermatozoa found in the ejaculate after surgery) and 30 controls...
March 23, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29553053/bone-targeted-therapies-to-reduce-skeletal-morbidity-in-prostate-cancer
#16
Tanya B Dorff, Neeraj Agarwal
Bone metastases are the main driver of morbidity and mortality in advanced prostate cancer. Targeting the bone microenvironment, a key player in the pathogenesis of bone metastasis, has become one of the mainstays of therapy in men with advanced prostate cancer. This review will evaluate the data supporting the use of bone-targeted therapy, including (1) bisphosphonates such as zoledronic acid, which directly target osteoclasts, (2) denosumab, a receptor activator of nuclear factor-kappa B (RANK) ligand inhibitor, which targets a key component of bone stromal interaction, and (3) radium-223, an alpha-emitting calcium mimetic, which hones to the metabolically active areas of osteoblastic metastasis and induces double-strand breaks in the DNA...
March 16, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29536949/the-path-forward-in-prostate-cancer-therapeutics
#17
EDITORIAL
Jeanny B Aragon-Ching, Ravi A Madan
No abstract text is available yet for this article.
March 9, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29516878/predictive-factors-for-pituitary-response-to-pulsatile-gnrh-therapy-in-patients-with-congenital-hypogonadotropic-hypogonadism
#18
Jiang-Feng Mao, Xi Wang, Jun-Jie Zheng, Zhao-Xiang Liu, Hong-Li Xu, Bing-Kun Huang, Min Nie, Xue-Yan Wu
Pulsatile gonadotropin-releasing hormone (GnRH) may induce spermatogenesis in most patients with congenital hypogonadotropic hypogonadism (CHH) by stimulating gonadotropin production, while the predictors for a pituitary response to pulsatile GnRH therapy were rarely investigated. Therefore, the aim of our study is to investigate predictors of the pituitary response to pulsatile GnRH therapy. This retrospective cohort study included 82 CHH patients who received subcutaneous pulsatile GnRH therapy for at least 1 month...
March 6, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29516877/role-of-inhibiting-lim-kinase2-in-improving-erectile-function-through-suppression-of-corporal-fibrosis-in-a-rat-model-of-cavernous-nerve-injury
#19
Juhyun Park, Sung Yong Cho, Kwanjin Park, Ji Sun Chai, Hwancheol Son, Soo Woong Kim, Jae-Seung Paick, Min Chul Cho
We evaluated whether LIM-kinase 2 inhibitor (LIMK2i) could improve erectile function by suppressing corporal fibrosis through the normalization of the Rho-associated coiled-coil protein kinase 1 (ROCK1)/LIMK2/Cofilin pathway in a rat model of cavernous nerve crush injury (CNCI). Sixty 11-week-old male Sprague-Dawley rats were divided equally into five groups: sham surgery (S), CNCI (I), and CNCI treated with low-dose (L), medium-dose (M), and high-dose (H) LIMK2i. The L, M, and H groups were treated with a daily intraperitoneal injection of LIMK2i (2...
March 6, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29516876/chronic-epididymitis-and-grade-iii-varicocele-and-their-associations-with-semen-characteristics-in-men-consulting-for-couple-infertility
#20
Alejandro Oliva, Luc Multigner
Chronic epididymitis and varicocele are frequently observed genital disorders in men consulting for couple infertility, but their impact on semen characteristics at the time of infertility consultation is still a matter of debate. We investigated 652 male partners of couples who had their first infertility consultation between 1999 and 2015 in Argentina. Men with chronic epididymitis (n = 253), Grade III varicocele (n = 106), and both conditions (n = 125) were compared with a control group (n = 168) composed of men without these disorders or any other recognized causes of male infertility...
March 6, 2018: Asian Journal of Andrology
journal
journal
34978
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"