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Asian Journal of Andrology

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https://www.readbyqxmd.com/read/28905815/psa-time-to-nadir-as-a-prognostic-factor-of-first-line-docetaxel-treatment-in-castration-resistant-prostate-cancer-evidence-from-patients-in-northwestern-china
#1
Kai-Jie Wu, Xin-Qi Pei, Ge Tian, Da-Peng Wu, Jin-Hai Fan, Yu-Mei Jiang, Da-Lin He
Docetaxel-based chemotherapy remains the first-line treatment for patients with metastatic castration-resistant prostate cancer (mCRPC) in China; however, the prognostic factors associated with effects in these patients are still controversial. In this study, we retrospectively reviewed the data from 71 eligible Chinese patients who received docetaxel chemotherapy from 2009 to 2016 in our hospital and experienced a reduction of prostate-specific antigen (PSA) level ≥50% during the treatment and investigated the potential role of time to nadir (TTN) of PSA...
September 12, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28879867/psa-screening-for-whom-and-when
#2
Peter Albers
No abstract text is available yet for this article.
September 5, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28879866/management-and-outcomes-of-penile-fracture-a-retrospective-analysis-of-62-cases-with-long-term-assessment
#3
LETTER
Zhuang Tang, Lu Yang, Qiang Wei, Fan Wang, Liang-Ren Liu, Ping Tan, Shi Qiu, Yu Fan
No abstract text is available yet for this article.
September 5, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28879865/proton-pump-inhibitor-use-does-not-affect-semen-quality-in-subfertile-men
#4
Sorena Keihani, James R Craig, Chong Zhang, Angela P Presson, Jeremy B Myers, William O Brant, Kenneth I Aston, Benjamin R Emery, Timothy G Jenkins, Douglas T Carrell, James M Hotaling
Proton-pump inhibitors (PPIs) are among the most widely used drugs worldwide. PPI use has recently been linked to adverse changes in semen quality in healthy men; however, the effects of PPI use on semen parameters remain largely unknown specifically in cases with male factor infertility. We examined whether PPI use was associated with detrimental effects on semen parameters in a large population of subfertile men. We retrospectively reviewed data from 12 257 subfertile men who had visited our fertility clinic from 2003 to 2013...
September 5, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28869220/microdissection-testicular-extraction-for-a-patient-with-transverse-testicular-ectopia-and-testicular-fusion
#5
LETTER
Chen Chen, Yi-Chun Wang, Ya-Min Wang, Chao Qin, Ning-Hong Song
No abstract text is available yet for this article.
September 1, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28869219/andrographolide-sensitizes-prostate-cancer-cells-to-trail-induced-apoptosis
#6
Ruo-Jing Wei, Xin-Shi Zhang, Da-Lin He
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising agent for anticancer therapy. The identification of small molecules that can establish the sensitivity of prostate cancer (PCa) cells to TRAIL-induced apoptosis is crucial for the targeted treatment of PCa. PC3, DU145, JAC-1, TsuPr1, and LNCaP cells were treated with Andrographolide (Andro) and TRAIL, and the apoptosis was measured using the Annexin V/PI double staining method. Real time-polymerase chain reaction (PCR) and Western blot analysis were performed to measure the expression levels of target molecules...
September 1, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28857053/a-rare-polypyrimidine-tract-mutation-in-the-androgen-receptor-gene-results-in-complete-androgen-insensitivity-syndrome
#7
LETTER
Shi-Min Yuan, Huan Huang, Chao-Feng Tu, Juan Du, Da-Bao Xu, Ge Lin, Guang-Xiu Lu, Yue-Qiu Tan
No abstract text is available yet for this article.
August 29, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28857052/antiarrhythmic-drug-usage-and-prostate-cancer-a-population-based-cohort-study
#8
Li-Ting Kao, Chung-Chien Huang, Herng-Ching Lin, Chao-Yuan Huang
Even though the relationship between antiarrhythmic drug usage and subsequent prostate cancer (PCa) risk has recently been highlighted, relevant findings in the previous literature are still inconsistent. In addition, very few studies have attempted to investigate the association between sodium channel blockers or potassium channel blockers for arrhythmia and the subsequent PCa risk. Therefore, this cohort study aimed to find the relationship between antiarrhythmic drug usage and the subsequent PCa risk using a population-based dataset...
August 29, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28836508/circulating-tumor-cells-and-their-role-in-prostate-cancer
#9
REVIEW
Moritz Maas, Miriam Hegemann, Steffen Rausch, Jens Bedke, Arnulf Stenzl, Tilman Todenhöfer
Circulating tumor cells (CTC) have become an important biomarker in patients with advanced prostate cancer. CTC count has been demonstrated to be a prognostic factor for overall survival in patients with metastatic castration-resistant prostate cancer (mCRPC). In localized prostate cancer, a clear correlation between CTC counts and clinicopathological risk parameters and outcome has not been observed. Currently, the focus of research is shifting from CTC enumeration towards molecular characterization of CTC leading to the discovery of markers predicting treatment response...
August 22, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28816202/testosterone-treatment-and-cardiovascular-events-in-prescription-database-studies
#10
REVIEW
Molly M Shores
Over the past decade, there has been a substantial increase in the number of men who are treated with testosterone. Despite this increase in the use of testosterone, the risks of adverse cardiovascular events are unclear as meta-analyses have reported conflicting findings and no clinical studies have been large enough or long enough to adequately assess for cardiovascular risks. The goal of this paper is to review large prescription database studies of testosterone treatment and adverse cardiovascular events and mortality with the aim of providing some guidance for clinicians and researchers in this controversial area...
August 11, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28816201/risk-factors-and-the-prognosis-of-sexual-dysfunction-in-male-patients-with-pituitary-adenomas-a-multivariate-analysis
#11
Wen-Jian-Long Zhou, Shun-Chang Ma, Min Zhao, Chang Liu, Xiu-Dong Guan, Zhao-Shi Bao, Gui-Jun Jia, Wang Jia
The impact of sexual dysfunction (SD) is distressing to many male patients with pituitary adenomas which affect both physical and psychological health. The research explored to identify risk factors affecting sexual function and the prognosis of male patients with pituitary adenomas. Two hundred and fifty-four male patients, who aged between 18 and 60 (mean ± s.d.: 44.16 ± 10.14) years and diagnosed with pituitary adenomas, were retrospectively analyzed. One hundred and fifty-nine patients (62.6%) complained of SD prior to surgery...
August 11, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28782738/trials-of-testosterone-replacement-reporting-cardiovascular-adverse-events
#12
Thiago Gagliano-Jucá, Shehzad Basaria
The numbers of testosterone prescriptions written have increased several-fold worldwide, but the incidence of pathological hypogonadism due to hypothalamic, pituitary, and testicular disease has remained unchanged. Most of these prescriptions are being dispensed to middle-aged and older men who have experienced age-related decline in serum testosterone levels; a subset of the population in which benefits of testosterone replacement is at best, modest. Recently, some randomized controlled trials have reported increased cardiovascular events in men (mainly older men and those with prevalent cardiovascular disease) with testosterone use, and a few recent meta-analyses have confirmed these findings...
August 4, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28782737/contemporary-grading-of-prostate-cancer-2017-update-for-pathologists-and-clinicians
#13
Silvia Gasparrini, Alessia Cimadamore, Marina Scarpelli, Francesco Massari, Andrea Doria, Roberta Mazzucchelli, Liang Cheng, Antonio Lopez-Beltran, Rodolfo Montironi
The Gleason grading system for prostate cancer (PCa) was developed in the 1960s by DF Gleason. Due to changes in PCa detection and treatment, the application of the Gleason grading system has changed considerably in pathology routine practice. Two consensus conferences were held in 2005 and in 2014 to update PCa Gleason grading. This review provides a summary of the changes in the grading of PCa from the original Gleason grading system to the prognostic grade grouping, as well as a discussion of the clinical significance of the percentage of Gleason patterns 4 and 5...
August 4, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28695865/zinner-s-syndrome-clinical-features-and-imaging-diagnosis
#14
LETTER
Xiao-Song Jiang, Huan-Jun Wang, Jin-Hua Lin, Yan Guo, Can-Hui Sun, Ling Lin, Jian Guan
No abstract text is available yet for this article.
July 11, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28695864/the-role-of-the-serum-testosterone-levels-as-a-predictor-of-prostate-cancer-in-patients-with-atypical-small-acinar-proliferation-at-the-first-prostate-biopsy
#15
Lucio Dell'Atti, Andrea B Galosi
The current literature does not support the usefulness of clinical markers on predicting which patients with atypical small acinar proliferation (ASAP) are more likely to progress to prostate cancer (PCa). Androgens have long been considered to be the potential risk factors for PCa. However, the role of testosterone is controversial. The present study aims to analyze the relationship between serum testosterone (TS) levels and the diagnosis of PCa after a first prostate biopsy in patients affected by ASAP. This retrospective study included 143 patients diagnosed with ASAP in an initial transrectal ultrasound-guided prostate biopsy for suspicious PCa according to the European Association of Urology guidelines...
July 11, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28675154/redo-surgery-for-failed-hypospadias-treatment-using-a-novel-single-stage-repair
#16
LETTER
Min Wu, Shu-Zhu Chen, Wei-Jing Ye, Yi-Dong Liu
No abstract text is available yet for this article.
July 4, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28675153/sperm-dna-damage-has-a-negative-effect-on-early-embryonic-development-following-in-vitro-fertilization
#17
Wei-Wei Zheng, Ge Song, Qi-Ling Wang, Shan-Wen Liu, Xiao-Li Zhu, Shun-Mei Deng, An Zhong, Yu-Mei Tan, Ying Tan
Sperm DNA damage is recognized as an important biomarker of male infertility. To investigate this, sperm DNA damage was assessed by the sperm chromatin dispersion (SCD) test in semen and motile spermatozoa harvested by combined density gradient centrifugation (DGC) and swim-up in 161 couples undergoing in vitro fertilization (IVF). Semen analysis and sperm DNA damage results were compared between couples who did or did not achieve pregnancy. The sperm DNA damage level was significantly different between the two groups (P < 0...
June 30, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28782736/the-asian-journal-of-andrology-s-audit-to-detect-fake-reviewing-trust-%C3%A2-but-check
#18
EDITORIAL
Yi-Fei Wang, David Handelsman, Trevor G Cooper
No abstract text is available yet for this article.
September 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28566558/testosterone-treatment-in-older-men-glass-half-empty-or-half-full
#19
Brendan J Nolan, Mathis Grossmann
No abstract text is available yet for this article.
September 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/27873769/androgen-receptor-gene-cag-and-ggn-repeat-lengths-as-predictors-of-recovery-of-spermatogenesis-following-testicular-germ-cell-cancer-treatment
#20
Karolina Bogefors, Yvonne Lundberg Giwercman, Jakob Eberhard, Olof Stahl, Eva Cavallin-Stahl, Gabriella Cohn-Cedermark, Stefan Arver, Aleksander Giwercman
Spermatogenesis is an androgen-regulated process that depends on the action of androgen receptor (AR). Sperm production may be affected in men treated for testicular cancer (TC), and it is important to identify the factors influencing the timing of spermatogenesis recovery following cancer treatment. It is known that the CAG and GGN repeat numbers affect the activity of the AR; therefore, the aim of this study is to investigate if the CAG and GGN polymorphisms in the AR gene predict recovery of sperm production after TC treatment...
September 2017: Asian Journal of Andrology
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