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Asian Journal of Andrology

Shathmigha Ketheeswaran, Thor Haahr, Betina Povlsen, Rita Laursen, Birgit Alsbjerg, Helle Elbaek, Sandro C Esteves, Peter Humaidan
No abstract text is available yet for this article.
September 18, 2018: Asian Journal of Andrology
Zhi-Hua Wans, Yuan-Jie Zhang, Lin Chen, Yong-Lian Guo, Guo-Hao Li, Ding Wu, Yong Wang
Type 2 diabetes mellitus (T2DM) is a common cause of erectile dysfunction (ED). It has been demonstrated that G protein-coupled receptor kinase 2 (GRK2) overexpression contributes to diabetic endothelial dysfunction and oxidative stress, which also underlies ED in T2DM. We hypothesized that GRK2 overexpressed and attenuated endothelial function of the cavernosal tissue in a rat model of T2DM. T2DM rats were established by feeding with a high-fat diet (HFD) for 2 weeks and then administering two intraperitoneal (IP) injections of a low dose of streptozotocin (STZ), followed by continuous feeding with a HFD for 6 weeks...
September 14, 2018: Asian Journal of Andrology
Xue-Sheng Wang, Li-Qiang Guo, Zhi-Ying Xiao, Yong Guan, Jian-Ye Zhang, Ming Li, Zhen Ma, Zhi-He Xu, Guo-Mei Ye, Ming-Zhen Yuan
The aim of our study was to investigate the role of platelet parameters including mean platelet volume (MPV) and platelet count (PC) in the pathogenesis of penile arteriogenic erectile dysfunction (ED) and to evaluate the association between the platelet parameters and arteriogenic ED. There were 244 patients with ED (based on the International Index of Erectile Function [IIEF]-5 ≤21) and 60 healthy controls (IIEF-5 >21) enrolled. All participants were asked to undergo a laboratory examination, and penile vascular function was evaluated using penile color Doppler ultrasonography (pDUS)...
September 7, 2018: Asian Journal of Andrology
Li-Ning Jiang, Ya-Bin Liu, Bing-Hui Li
Lycopene is a natural compound that alleviates oxidative stress and inflammation, exerting therapeutic effects in a number of cancers. The aim of this study is to investigate the efficacy of lycopene in inhibiting prostate cancer. Cell viability assays indicated the dose- and time-dependent toxicity of lycopene in prostate cancer cells. Annexin V/propidium iodide double-staining assays revealed the strong apoptotic effects of lycopene. The levels of inflammatory factors, including interleukin-1 (IL1), IL6, IL8, and tumor necrosis factor-α (TNF-α), in lycopene-treated cells were also reduced by lycopene treatment...
September 7, 2018: Asian Journal of Andrology
Fabiana A de Oliveira, Waldemar S Costa, Francisco J B Sampaio, Bianca M Gregorio
High-fat diets affect male reproduction and sexual function. Therefore, we evaluated the effects of prolonged resveratrol administration on the metabolic, sperm, and testicular parameters of rats fed a cafeteria diet. Male Wistar rats were divided at weaning into control (C, n = 20) and cafeteria (CAF, n = 16) groups. At 3 months, half of them were given daily supplementations of resveratrol (C-R, n = 10; CAF-R, n = 8) at a dosage of 30 mg kg-1 body mass for 2 months. Animals were killed at 5 months of age, and blood, spermatozoa, and testes were collected for further analysis...
September 7, 2018: Asian Journal of Andrology
Cong Shen, Jun Yu, Xi Zhang, Chen-Chen Liu, Yue-Shuai Guo, Jia-Wei Zhu, Ke Zhang, Yi Yu, Ting-Ting Gao, Shen-Min Yang, Hong Li, Bo Zheng, Xiao-Yan Huang
While it is known that spermatogonial stem cells (SSCs) initiate the production of male germ cells, the mechanisms of SSC self-renewal, proliferation, and differentiation remain poorly understood. We have previously identified Strawberry Notch 1 (SBNO1), a vertebrate strawberry notch family protein, in the proteome profile for mouse SSC maturation and differentiation, revealing SBNO1 is associated with neonatal testicular development. To explore further the location and function of SBNO1 in the testes, we performed Sbno1 gene knockdown in mice to study the effects of SBNO1 on neonatal testicular and SSC development...
September 7, 2018: Asian Journal of Andrology
Ho-Fai Wong, Chi-Hang Yee, Jeremy Y C Teoh, Samson Y S Chan, Peter K F Chiu, Ho-Yuen Cheung, Simon S M Hou, Chi Fai Ng
No abstract text is available yet for this article.
September 4, 2018: Asian Journal of Andrology
Chun-Jung Lin, U-Ging Lo, Jer-Tsong Hsieh
Prostate cancer (PCa) is the most common cause of malignancy in males and the third leading cause of cancer mortality in the United States. The standard care for primary PCa with local invasive disease mainly is surgery and radiation. For patients with distant metastases, androgen deprivation therapy (ADT) is a gold standard. Regardless of a favorable outcome of ADT, patients inevitably relapse to an end-stage castration-resistant prostate cancer (CRPC) leading to mortality. Therefore, revealing the mechanism and identifying cellular components driving aggressive PCa is critical for prognosis and therapeutic intervention...
September 4, 2018: Asian Journal of Andrology
Jin-Woo Jung, Young Dong Yu, Young Ju Lee, Jung Jun Kim, Hak Min Lee, Jong Jin Oh, Sangchul Lee, Sang Wook Lee, Sang Eun Lee, Seong Jin Jeong
We evaluated whether the prostate-specific antigen (PSA) mass or free PSA (fPSA) mass (i.e., absolute amount of total circulating PSA or fPSA protein, respectively), versus serum PSA or fPSA concentration, improves the accuracy of predicting the total prostate volume (TPV) in relation to obesity. Among men whose multicore (≥12) transrectal prostate biopsy was negative, 586 who had a PSA of ≤10 ng ml-1 and underwent the fPSA test prior to biopsy were enrolled. The PSA mass or fPSA mass (μ g) was calculated by multiplying the serum level by plasma volume...
September 4, 2018: Asian Journal of Andrology
Sheba Jarvis, Heather K Yee, Natalia Thomas, Imok Cha, Kedar Che Prasad, Jonathan W A Ramsay, Paul J Turek
We sought to evaluate the ability of fine-needle aspiration (FNA) mapping to find sperm and to guide sperm retrieval after failed microdissection testicular sperm extraction (micro-TESE) in nonobstructive azoospermic men. In this study of consecutive male infertility cases, interventions included testicular FNA mapping and subsequent sperm retrieval. Outcomes included the frequency and location of found sperm on FNA maps after failed micro-TESE and the salvage sperm retrieval success. Among 548 patients undergoing FNA mapping from 2010 to 2016, 82 men with previous micro-TESE procedures were identified...
August 31, 2018: Asian Journal of Andrology
Cihan H Demirel, Muammer Altok, John W Davis
In recent years, it has come a long way in the diagnosis, treatment, and follow-up of prostate cancer. Beside this, it was argued that definitive treatments could cause overtreatment, particularly in the very low, low, and favorable risk group. When alternative treatment and follow-up methods are being considered for this group of patients, active surveillance is seen as a good alternative for patients with very low and low-risk groups in this era. However, it has become necessary to find other alternatives for patients in the favorable risk group or patients who cannot adopt active follow-up...
August 31, 2018: Asian Journal of Andrology
Rui-Zhi Xue, Zheng-Yan Tang, Zhi Chen, Liang Huang
Symptomatic seminal vesicle cysts (SVCs), especially those of a large size, can be removed by surgical treatments. Currently, open surgeries for SVC are rarely performed due to their extensive surgical trauma, and minimally invasive surgical therapies for treating seminal vesicle cysts are still in the early stages. In addition, relevant studies are mostly confined to case reports. In this study, we retrospectively reviewed 53 patients who had received transperitoneal laparoscopic unroofing or fenestration under seminal vesiculoscopy for SVC in our institution...
August 21, 2018: Asian Journal of Andrology
Makiko Tsutsumi, Naoko Fujita, Fumihiko Suzuki, Takashi Mishima, Satoko Fujieda, Michiko Watari, Nobuhiro Takahashi, Hidefumi Tonoki, Osamu Moriwaka, Toshiaki Endo, Hiroki Kurahashi
No abstract text is available yet for this article.
August 17, 2018: Asian Journal of Andrology
Yan Zhang, Wei Huang, Zheng-Hui Hu, Min Cao, Hong-Shen Wu, Jun-Jie Cao, Fei-Fan Wang, Xiao-Dong Jin
No abstract text is available yet for this article.
August 14, 2018: Asian Journal of Andrology
Young Eun Yoon, Hyung Ho Lee, Sung Yul Park, Hong Sang Moon, Dong Suk Kim, Seung-Hun Song, Dae Keun Kim
This study comprises a systematic review and meta-analysis of microsurgical vasoepididymostomy outcomes in epididymal obstructive azoospermia. A comprehensive literature search was performed using Medline, Embase, and the Cochrane library that included all studies related to microsurgical vasoepididymostomy. Keywords included "vasoepididymostomy," "epididymovasostomy," "epididymal obstruction," and "epididymis obstruction." Event rate and risk ratio (RR) were estimated...
August 14, 2018: Asian Journal of Andrology
Jin-Ge Zhao, Jian-Dong Liu, Peng-Fei Shen, Xin Tang, Guang-Xi Sun, Xing-Ming Zhang, Jun-Ru Chen, Kun-Peng Shu, Ming Shi, Hao Zeng
Even in the era of novel targeted agents, switching to a second-line nonsteroidal antiandrogen (NSAA) is still widely used in treating metastatic castration-resistant prostate cancer (mCRPC), especially in undeveloped countries. However, whether prior treatment with a second-line NSAA would impact the efficacy of abiraterone acetate (Abi) remains uncertain. In the current study, 87 mCRPC patients treated with Abi were analyzed. Among them, 21 were treated with a second-line NSAA (from bicalutamide to flutamide) before receiving abiraterone, while the remaining 66 received Abi directly...
August 14, 2018: Asian Journal of Andrology
Yiji Liao, Kexin Xu
Epigenetics is the main mechanism that controls transcription of specific genes with no changes in the underlying DNA sequences. Epigenetic alterations lead to abnormal gene expression patterns that contribute to carcinogenesis and persist throughout disease progression. Because of the reversible nature, epigenetic modifications emerge as promising anticancer drug targets. Several compounds have been developed to reverse the aberrant activities of enzymes involved in epigenetic regulation, and some of them show encouraging results in both preclinical and clinical studies...
August 7, 2018: Asian Journal of Andrology
Peng Hong, Run-Qi Guo, Gang Song, Kai-Wei Yang, Lei Zhang, Xue-Song Li, Kai Zhang, Li-Qun Zhou
We aimed to investigate the prognostic value of chromogranin A (CgA) in castration-resistant prostate cancer (CRPC). We conducted a systematic literature search of PubMed, Web of Science, and EMBASE for citations published prior to September 2017 that described CgA and CRPC and performed a standard meta-analysis on survival outcomes. Our meta-analysis included eight eligible studies with 686 patients. The results were as follows: progression-free survival (PFS) was associated with CgA level (hazard ratio [HR] = 2...
July 31, 2018: Asian Journal of Andrology
James A Browne, Shih-Hsing Leir, Scott E Eggener, Ann Harris
The epithelium of the human epididymis maintains an appropriate luminal environment for sperm maturation that is essential for male fertility. Regional expression of small noncoding RNAs such as microRNAs contributes to segment-specific gene expression and differentiated functions. MicroRNA profiles were reported in human epididymal tissues but not specifically in the epithelial cells derived from those regions. Here, we reveal miRNA signatures of primary cultures of caput, corpus, and cauda epididymis epithelial cells and of the tissues from which they were derived...
July 24, 2018: Asian Journal of Andrology
Yi-Nan Wang, Qing Zeng, Feng Xiong, Yan Zeng
Genital size is a crucial index for the assessment of male sexual development, as abnormal penile or testicular size may be the earliest visible clinical manifestation of some diseases. However, there is a lack of data regarding penile and testicular size measurements for Chinese boys at all stages of childhood and puberty. This cross-sectional study aimed to develop appropriate growth curves and charts for male external genitalia among children and adolescents aged 0-17 years in Chongqing, China. A total of 2974 boys were enrolled in the present study...
July 20, 2018: Asian Journal of Andrology
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