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Yulong Gao, Fernando Souza-Fonseca-Guimaraes, Tobias Bald, Susanna S Ng, Arabella Young, Shin Foong Ngiow, Jai Rautela, Jasmin Straube, Nic Waddell, Stephen J Blake, Juming Yan, Laurent Bartholin, Jason S Lee, Eric Vivier, Kazuyoshi Takeda, Meriem Messaoudene, Laurence Zitvogel, Michele W L Teng, Gabrielle T Belz, Christian R Engwerda, Nicholas D Huntington, Kyohei Nakamura, Michael Hölzel, Mark J Smyth
No abstract text is available yet for this article.
March 21, 2024: Nature Immunology
#22
JOURNAL ARTICLE
Kathrin M Bernt
No abstract text is available yet for this article.
March 21, 2024: Nature Immunology
#23
JOURNAL ARTICLE
Calvin Jon A Leonen, Hironori Funabiki
No abstract text is available yet for this article.
March 21, 2024: Nature Immunology
#24
JOURNAL ARTICLE
Xuan Zhang, Baobao Song, Maximillian J Carlino, Guangyuan Li, Kyle Ferchen, Mi Chen, Evrett N Thompson, Bailee N Kain, Dan Schnell, Kairavee Thakkar, Michal Kouril, Kang Jin, Stuart B Hay, Sidharth Sen, David Bernardicius, Siyuan Ma, Sierra N Bennett, Josh Croteau, Ornella Salvatori, Melvin H Lye, Austin E Gillen, Craig T Jordan, Harinder Singh, Diane S Krause, Nathan Salomonis, H Leighton Grimes
Analysis of the human hematopoietic progenitor compartment is being transformed by single-cell multimodal approaches. Cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) enables coupled surface protein and transcriptome profiling, thereby revealing genomic programs underlying progenitor states. To perform CITE-seq systematically on primary human bone marrow cells, we used titrations with 266 CITE-seq antibodies (antibody-derived tags) and machine learning to optimize a panel of 132 antibodies...
March 21, 2024: Nature Immunology
#25
JOURNAL ARTICLE
Jonathan H Chen, Linda T Nieman, Maxwell Spurrell, Vjola Jorgji, Liad Elmelech, Peter Richieri, Katherine H Xu, Roopa Madhu, Milan Parikh, Izabella Zamora, Arnav Mehta, Christopher S Nabel, Samuel S Freeman, Joshua D Pirl, Chenyue Lu, Catherine B Meador, Jaimie L Barth, Mustafa Sakhi, Alexander L Tang, Siranush Sarkizova, Colles Price, Nicolas F Fernandez, George Emanuel, Jiang He, Katrina Van Raay, Jason W Reeves, Keren Yizhak, Matan Hofree, Angela Shih, Moshe Sade-Feldman, Genevieve M Boland, Karin Pelka, Martin J Aryee, Mari Mino-Kenudson, Justin F Gainor, Ilya Korsunsky, Nir Hacohen
The organization of immune cells in human tumors is not well understood. Immunogenic tumors harbor spatially localized multicellular 'immunity hubs' defined by expression of the T cell-attracting chemokines CXCL10/CXCL11 and abundant T cells. Here, we examined immunity hubs in human pre-immunotherapy lung cancer specimens and found an association with beneficial response to PD-1 blockade. Critically, we discovered the stem-immunity hub, a subtype of immunity hub strongly associated with favorable PD-1-blockade outcome...
March 19, 2024: Nature Immunology
#26
JOURNAL ARTICLE
Yun Xia, Xin Li, Nana Bie, Wen Pan, Ya-Ru Miao, Mei Yang, Yan Gao, Chuang Chen, Hanqing Liu, Lu Gan, An-Yuan Guo
Combination therapy is a promising therapeutic strategy to enhance the efficacy of immune checkpoint blockade (ICB); however, predicting drugs for effective combination is challenging. Here we developed a general data-driven method called CM-Drug for screening compounds that can boost ICB treatment efficacy based on core and minor gene sets identified between responsive and nonresponsive samples in ICB therapy. The CM-Drug method was validated using melanoma and lung cancer mouse models, with combined therapeutic efficacy demonstrated in eight of nine predicted compounds...
March 18, 2024: Nature Immunology
#27
LETTER
Joseph M Gaballa, Jesper Falkesgaard Højen, Dennis M De Graaf, Jesus Amo-Aparicio, Carlo Marchetti, Giulio Cavalli, Alberto Dinarello, Suzhao Li, Michaele Francesco Corbisiero, Isak W Tengesdal, Jasmina S Redzic, Tania Azam, William S Webber, Karl A Pankratz, Makenna J May, Fabio Cominelli, Elan Z Eisenmesser, Soohyun Kim, Charles A Dinarello, Diana Boraschi
No abstract text is available yet for this article.
March 18, 2024: Nature Immunology
#28
Safia Deddouche, Nicolas Matt, Aidan Budd, Stefanie Mueller, Cordula Kemp, Delphine Galiana-Arnoux, Catherine Dostert, Christophe Antoniewski, Jules A Hoffmann, Jean-Luc Imler
No abstract text is available yet for this article.
March 15, 2024: Nature Immunology
#29
JOURNAL ARTICLE
Thi H O Nguyen, Katherine Kedzierska
No abstract text is available yet for this article.
March 15, 2024: Nature Immunology
#30
JOURNAL ARTICLE
Valeria Fumagalli, Micol Ravà, Davide Marotta, Pietro Di Lucia, Elisa B Bono, Leonardo Giustini, Federica De Leo, Maura Casalgrandi, Emanuele Monteleone, Violette Mouro, Chiara Malpighi, Chiara Perucchini, Marta Grillo, Sara De Palma, Lorena Donnici, Silvia Marchese, Matteo Conti, Hiromi Muramatsu, Stanley Perlman, Norbert Pardi, Mirela Kuka, Raffaele De Francesco, Marco E Bianchi, Luca G Guidotti, Matteo Iannacone
Vaccines have reduced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) morbidity and mortality, yet emerging variants challenge their effectiveness. The prevailing approach to updating vaccines targets the antibody response, operating under the presumption that it is the primary defense mechanism following vaccination or infection. This perspective, however, can overlook the role of T cells, particularly when antibody levels are low or absent. Here we show, through studies in mouse models lacking antibodies but maintaining functional B cells and lymphoid organs, that immunity conferred by prior infection or mRNA vaccination can protect against SARS-CoV-2 challenge independently of antibodies...
March 14, 2024: Nature Immunology
#31
JOURNAL ARTICLE
Andrea Mencarelli, Pradeep Bist, Hae Woong Choi, Hanif Javanmard Khameneh, Alessandra Mortellaro, Soman N Abraham
The inflammasome components NLRP3 and ASC are cytosolic proteins, which upon sensing endotoxins or danger cues, form multimeric complexes to process interleukin (IL)-1β for secretion. Here we found that antigen (Ag)-triggered degranulation of IgE-sensitized mast cells (MCs) was mediated by NLRP3 and ASC. IgE-Ag stimulated NEK7 and Pyk2 kinases in MCs to induce the deposition of NLRP3 and ASC on granules and form a distinct protein complex (granulosome) that chaperoned the granules to the cell surface...
March 14, 2024: Nature Immunology
#32
Sandra Ryeom, Rebecca J Greenwald, Arlene H Sharpe, Frank McKeon
No abstract text is available yet for this article.
March 11, 2024: Nature Immunology
#33
JOURNAL ARTICLE
Xin He, Xiantao Zhang, Bolin Wu, Jieyi Deng, Yongli Zhang, Airu Zhu, Yaochang Yuan, Yingtong Lin, Achun Chen, Jinzhu Feng, Xiumei Wang, Shijian Wu, Yingying Liu, Jie Liu, Yalin Wang, Rong Li, Chaofeng Liang, Quyu Yuan, Yu Liang, Qiannan Fang, Zhihui Xi, Wenjie Li, Liting Liang, Zhenglai Zhang, Hui Tang, Yi Peng, Changwen Ke, Xiancai Ma, Weibin Cai, Ting Pan, Bingfeng Liu, Kai Deng, Jun Chen, Jincun Zhao, Xuepeng Wei, Ran Chen, Yiwen Zhang, Hui Zhang
The development of a vaccine specific to severe acute respiratory syndrome coronavirus 2 Omicron has been hampered due to its low immunogenicity. Here, using reverse mutagenesis, we found that a phenylalanine-to-serine mutation at position 375 (F375S) in the spike protein of Omicron to revert it to the sequence found in Delta and other ancestral strains significantly enhanced the immunogenicity of Omicron vaccines. Sequence FAPFFAF at position 371-377 in Omicron spike had a potent inhibitory effect on macrophage uptake of receptor-binding domain (RBD) nanoparticles or spike-pseudovirus particles containing this sequence...
March 7, 2024: Nature Immunology
#34
JOURNAL ARTICLE
Kaitlin R Carroll, Mark Mizrachi, Sean Simmons, Bahtiyar Toz, Czeslawa Kowal, Jeffrey Wingard, Nazila Tehrani, Aida Zarfeshani, Nina Kello, Lara El Khoury, Rachel Weissman-Tsukamoto, Joshua Z Levin, Bruce T Volpe, Betty Diamond
Cognitive impairment is a frequent manifestation of neuropsychiatric systemic lupus erythematosus, present in up to 80% of patients and leading to a diminished quality of life. In the present study, we used a model of lupus-like cognitive impairment that is initiated when antibodies that crossreact with excitatory neuronal receptors penetrate the hippocampus, causing immediate, self-limited, excitotoxic death of hippocampal neurons, which is then followed by a significant loss of dendritic complexity in surviving neurons...
March 6, 2024: Nature Immunology
#35
REVIEW
Philipp Sven Lars Schäfer, Daniel Dimitrov, Eduardo J Villablanca, Julio Saez-Rodriguez
The immune system comprises diverse specialized cell types that cooperate to defend the host against a wide range of pathogenic threats. Recent advancements in single-cell and spatial multi-omics technologies provide rich information about the molecular state of immune cells. Here, we review how the integration of single-cell and spatial multi-omics data with prior knowledge-gathered from decades of detailed biochemical studies-allows us to obtain functional insights, focusing on gene regulatory processes and cell-cell interactions...
February 27, 2024: Nature Immunology
#36
JOURNAL ARTICLE
Mathias Linnerbauer, Lena Lößlein, Oliver Vandrey, Anne Peter, Yanan Han, Thanos Tsaktanis, Emile Wogram, Maria Needhamsen, Lara Kular, Lisa Nagel, Julia Zissler, Marie Andert, Lisa Meszaros, Jannis Hanspach, Finnja Zuber, Ulrike J Naumann, Martin Diebold, Michael A Wheeler, Tobias Beyer, Lucy Nirschl, Ana Cirac, Frederik B Laun, Claudia Günther, Jürgen Winkler, Tobias Bäuerle, Maja Jagodic, Bernhard Hemmer, Marco Prinz, Francisco J Quintana, Veit Rothhammer
Central nervous system (CNS)-resident cells such as microglia, oligodendrocytes and astrocytes are gaining increasing attention in respect to their contribution to CNS pathologies including multiple sclerosis (MS). Several studies have demonstrated the involvement of pro-inflammatory glial subsets in the pathogenesis and propagation of inflammatory events in MS and its animal models. However, it has only recently become clear that the underlying heterogeneity of astrocytes and microglia can not only drive inflammation, but also lead to its resolution through direct and indirect mechanisms...
February 26, 2024: Nature Immunology
#37
JOURNAL ARTICLE
Lise Torp Jensen, Kathrine E Attfield, Lars Fugger
No abstract text is available yet for this article.
February 26, 2024: Nature Immunology
#38
Susanna S Ng, Fabian De Labastida Rivera, Juming Yan, Dillon Corvino, Indrajit Das, Ping Zhang, Rachel Kuns, Shashi Bhushan Chauhan, Jiajie Hou, Xian-Yang Li, Teija C M Frame, Benjamin A McEnroe, Eilish Moore, Jinrui Na, Jessica A Engel, Megan S F Soon, Bhawana Singh, Andrew J Kueh, Marco J Herold, Marcela Montes de Oca, Siddharth Sankar Singh, Patrick T Bunn, Amy Roman Aguilera, Mika Casey, Matthias Braun, Nazanin Ghazanfari, Shivangi Wani, Yulin Wang, Fiona H Amante, Chelsea L Edwards, Ashraful Haque, William C Dougall, Om Prakash Singh, Alan G Baxter, Michele W L Teng, Alex Loukas, Norelle L Daly, Nicole Cloonan, Mariapia A Degli-Esposti, Jude Uzonna, William R Heath, Tobias Bald, Siok-Keen Tey, Kyohei Nakamura, Geoffrey R Hill, Rajiv Kumar, Shyam Sundar, Mark J Smyth, Christian R Engwerda
No abstract text is available yet for this article.
February 15, 2024: Nature Immunology
#39
JOURNAL ARTICLE
Tobias Wertheimer, Pascale Zwicky, Lukas Rindlisbacher, Colin Sparano, Marijne Vermeer, Bruno Marcel Silva de Melo, Claudia Haftmann, Tamina Rückert, Aakriti Sethi, Stefanie Schärli, Anna Huber, Florian Ingelfinger, Caroline Xu, Daehong Kim, Philipp Häne, André Fonseca da Silva, Andreas Muschaweckh, Nicolas Nunez, Sinduya Krishnarajah, Natalie Köhler, Robert Zeiser, Mohamed Oukka, Thomas Korn, Sonia Tugues, Burkhard Becher
Interleukin-23 (IL-23) is a proinflammatory cytokine mainly produced by myeloid cells that promotes tumor growth in various preclinical cancer models and correlates with adverse outcomes. However, as to how IL-23 fuels tumor growth is unclear. Here, we found tumor-associated macrophages to be the main source of IL-23 in mouse and human tumor microenvironments. Among IL-23-sensing cells, we identified a subset of tumor-infiltrating regulatory T (Treg ) cells that display a highly suppressive phenotype across mouse and human tumors...
February 14, 2024: Nature Immunology
#40
JOURNAL ARTICLE
Santiago Valle Torres, Kevin Man, Tarek Elmzzahi, Darya Malko, David Chisanga, Yang Liao, Melanie Prout, Caitlin A Abbott, Adelynn Tang, Jian Wu, Matthias Becker, Teisha Mason, Vanessa Haynes, Carlson Tsui, Mehrnoush Hadaddzadeh Shakiba, Doaa Hamada, Kara Britt, Joanna R Groom, Shaun R McColl, Wei Shi, Matthew J Watt, Graham Le Gros, Bhupinder Pal, Marc Beyer, Ajithkumar Vasanthakumar, Axel Kallies
Visceral adipose tissue (VAT) is an energy store and endocrine organ critical for metabolic homeostasis. Regulatory T (Treg ) cells restrain inflammation to preserve VAT homeostasis and glucose tolerance. Here, we show that the VAT harbors two distinct Treg cell populations: prototypical serum stimulation 2-positive (ST2+ ) Treg cells that are enriched in males and a previously uncharacterized population of C-X-C motif chemokine receptor 3-positive (CXCR3+ ) Treg cells that are enriched in females. We show that the transcription factors GATA-binding protein 3 and peroxisome proliferator-activated receptor-γ, together with the cytokine interleukin-33, promote the differentiation of ST2+ VAT Treg cells but repress CXCR3+ Treg cells...
February 14, 2024: Nature Immunology
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