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Nature Immunology

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https://www.readbyqxmd.com/read/29449629/publisher-correction-human-%C3%AE-%C3%AE-t-cells-are-quickly-reconstituted-after-stem-cell-transplantation-and-show-adaptive-clonal-expansion-in-response-to-viral-infection
#1
Sarina Ravens, Christian Schultze-Florey, Solaiman Raha, Inga Sandrock, Melanie Drenker, Linda Oberdörfer, Annika Reinhardt, Inga Ravens, Maleen Beck, Robert Geffers, Constantin von Kaisenberg, Michael Heuser, Felicitas Thol, Arnold Ganser, Reinhold Förster, Christian Koenecke, Immo Prinz
In the version of this article initially published, a source of funding (Deutsche José Carreras Leukämie-Stiftung e.V. (DJCLS R12/29 to C.K. and I.P.)) was not included in the Acknowledgments section. The correct statement is as follows: "Supported by Deutsche Forschungsgemeinschaft, (SFB900/B8 to C.K. and I.P.; and PR727/4-1 to I.P.), Deutsche José Carreras Leukämie-Stiftung e.V. (DJCLS R12/29 to C.K. and I.P.) and the German Federal Ministry of Education and Research (01EO1302 to C.S.-F., C.K. and I...
February 14, 2018: Nature Immunology
https://www.readbyqxmd.com/read/29449628/publisher-correction-the-transcriptional-coactivator-taz-regulates-reciprocal-differentiation-of-t-h-17-cells-and-t-reg-cells
#2
Jing Geng, Shujuan Yu, Hao Zhao, Xiufeng Sun, Xun Li, Ping Wang, Xiaolin Xiong, Lixin Hong, Changchuan Xie, Jiahui Gao, Yiran Shi, Jiaqi Peng, Randy L Johnson, Nengming Xiao, Linrong Lu, Jiahuai Han, Dawang Zhou, Lanfen Chen
In the version of this article initially published, the institution name for affiliation 3 (Maryland Anderson Cancer Center) was incorrect. The correct institution is MD Anderson Cancer Center. The error has been corrected in the HTML and PDF versions of the article.
February 14, 2018: Nature Immunology
https://www.readbyqxmd.com/read/29434354/single-cell-gene-expression-reveals-a-landscape-of-regulatory-t-cell-phenotypes-shaped-by-the-tcr
#3
David Zemmour, Rapolas Zilionis, Evgeny Kiner, Allon M Klein, Diane Mathis, Christophe Benoist
CD4+ T regulatory cells (Treg) are central to immune homeostasis, their phenotypic heterogeneity reflecting the diverse environments and target cells that they regulate. To understand this heterogeneity, we combined single-cell RNA-seq, activation reporter and T cell receptor (TCR) analysis to profile thousands of Treg or conventional CD4+FoxP3- T cells (Tconv) from mouse lymphoid organs and human blood. Treg and Tconv pools showed areas of overlap, as resting 'furtive' Tregs with overall similarity to Tconvs or as a convergence of activated states...
February 12, 2018: Nature Immunology
https://www.readbyqxmd.com/read/29434353/transcription-factor-hoxb5-reprograms-b-cells-into-functional-t-lymphocytes
#4
Mengyun Zhang, Yong Dong, Fangxiao Hu, Dan Yang, Qianhao Zhao, Cui Lv, Ying Wang, Chengxiang Xia, Qitong Weng, Xiaofei Liu, Chen Li, Peiqing Zhou, Tongjie Wang, Yuxian Guan, Rongqun Guo, Lijuan Liu, Yang Geng, Hongling Wu, Juan Du, Zheng Hu, Sheng Xu, Jiekai Chen, Aibin He, Bing Liu, Demin Wang, Yong-Guang Yang, Jinyong Wang
Deletion of master regulators of the B cell lineage reprograms B cells into T cells. Here we found that the transcription factor Hoxb5, which is expressed in uncommitted hematopoietic progenitor cells but is not present in cells committed to the B cell or T cell lineage, was able to reprogram pro-pre-B cells into functional early T cell lineage progenitors. This reprogramming started in the bone marrow and was completed in the thymus and gave rise to T lymphocytes with transcriptomes, hierarchical differentiation, tissue distribution and immunological functions that closely resembled those of their natural counterparts...
February 12, 2018: Nature Immunology
https://www.readbyqxmd.com/read/29403049/metabolic-exhaustion-in-infection-cancer-and-autoimmunity
#5
REVIEW
E F McKinney, K G C Smith
It has become increasingly clear that changes in metabolism are not just consequences of T cell activation but instead are also essential drivers of that process that shape the extent and nature of differentiation and function. The process of T cell exhaustion has been linked to the outcome of chronic immune responses in multiple contexts, including chronic infection, cancer and autoimmunity. Factors that regulate the development and maintenance of exhaustion are of increasing interest as targets of therapeutic modulation...
February 5, 2018: Nature Immunology
https://www.readbyqxmd.com/read/29379119/the-immunology-of-hepatocellular-carcinoma
#6
REVIEW
Marc Ringelhan, Dominik Pfister, Tracy O'Connor, Eli Pikarsky, Mathias Heikenwalder
In contrast to most other malignancies, hepatocellular carcinoma (HCC), which accounts for approximately 90% of primary liver cancers, arises almost exclusively in the setting of chronic inflammation. Irrespective of etiology, a typical sequence of chronic necroinflammation, compensatory liver regeneration, induction of liver fibrosis and subsequent cirrhosis often precedes hepatocarcinogenesis. The liver is a central immunomodulator that ensures organ and systemic protection while maintaining immunotolerance...
January 29, 2018: Nature Immunology
https://www.readbyqxmd.com/read/29358709/tumor-derived-exosomes-antagonize-innate-antiviral-immunity
#7
Liang Gao, Lin Wang, Tong Dai, Ke Jin, Zhengkui Zhang, Shuai Wang, Feng Xie, Pengfei Fang, Bing Yang, Huizhe Huang, Hans van Dam, Fangfang Zhou, Long Zhang
Malignancies can compromise innate immunity, but the mechanisms of this are largely unknown. Here we found that, via tumor-derived exosomes (TEXs), cancers were able to transfer activated epidermal growth factor receptor (EGFR) to host macrophages and thereby suppress innate antiviral immunity. Screening of the human kinome identified the kinase MEKK2 in macrophages as an effector of TEX-delivered EGFR that negatively regulated the antiviral immune response. In the context of experimental tumor implantation, MEKK2-deficient mice were more resistant to viral infection than were wild-type mice...
January 22, 2018: Nature Immunology
https://www.readbyqxmd.com/read/29358708/selective-autophagy-of-the-adaptor-trif-regulates-innate-inflammatory-signaling
#8
Mohammad Samie, Junghyun Lim, Erik Verschueren, Joshua M Baughman, Ivan Peng, Aaron Wong, Youngsu Kwon, Yasin Senbabaoglu, Jason A Hackney, Mary Keir, Brent Mckenzie, Donald S Kirkpatrick, Menno van Lookeren Campagne, Aditya Murthy
Defective autophagy is linked to diseases such as rheumatoid arthritis, lupus and inflammatory bowel disease (IBD). However, the mechanisms by which autophagy limits inflammation remain poorly understood. Here we found that loss of the autophagy-related gene Atg16l1 promoted accumulation of the adaptor TRIF and downstream signaling in macrophages. Multiplex proteomic profiling identified SQSTM1 and Tax1BP1 as selective autophagy-related receptors that mediated the turnover of TRIF. Knockdown of Tax1bp1 increased production of the cytokines IFN-β and IL-1β...
January 22, 2018: Nature Immunology
https://www.readbyqxmd.com/read/29358707/the-rna-binding-protein-ptbp1-is-necessary-for-b-cell-selection-in-germinal-centers
#9
Elisa Monzón-Casanova, Michael Screen, Manuel D Díaz-Muñoz, Richard M R Coulson, Sarah E Bell, Greta Lamers, Michele Solimena, Christopher W J Smith, Martin Turner
Antibody affinity maturation occurs in germinal centers (GCs), where B cells cycle between the light zone (LZ) and the dark zone. In the LZ, GC B cells bearing immunoglobulins with the highest affinity for antigen receive positive selection signals from helper T cells, which promotes their rapid proliferation. Here we found that the RNA-binding protein PTBP1 was needed for the progression of GC B cells through late S phase of the cell cycle and for affinity maturation. PTBP1 was required for proper expression of the c-MYC-dependent gene program induced in GC B cells receiving T cell help and directly regulated the alternative splicing and abundance of transcripts that are increased during positive selection to promote proliferation...
January 22, 2018: Nature Immunology
https://www.readbyqxmd.com/read/29348508/adipose-tissue-tm-cells
#10
Ioana Visan
No abstract text is available yet for this article.
January 18, 2018: Nature Immunology
https://www.readbyqxmd.com/read/29348507/stressed-out-ros-take-a-silent-death-route
#11
Sannula Kesavardhana, Thirumala-Devi Kanneganti
No abstract text is available yet for this article.
January 18, 2018: Nature Immunology
https://www.readbyqxmd.com/read/29348506/macrophages-damage-control
#12
Zoltan Fehervari
No abstract text is available yet for this article.
January 18, 2018: Nature Immunology
https://www.readbyqxmd.com/read/29348505/antibiotics-immune-system-interactions
#13
Zoltan Fehervari
No abstract text is available yet for this article.
January 18, 2018: Nature Immunology
https://www.readbyqxmd.com/read/29348504/trials-and-tribble-ations-of-tissue-trm-cells
#14
Jun Siong Low, Susan M Kaech
No abstract text is available yet for this article.
January 18, 2018: Nature Immunology
https://www.readbyqxmd.com/read/29348503/nkt-cells-aid-antiviral-responses
#15
Laurie A Dempsey
No abstract text is available yet for this article.
January 18, 2018: Nature Immunology
https://www.readbyqxmd.com/read/29348502/stress-induced-depression
#16
Laurie A Dempsey
No abstract text is available yet for this article.
January 18, 2018: Nature Immunology
https://www.readbyqxmd.com/read/29348501/myocardial-infarct-inflammation
#17
Ioana Visan
No abstract text is available yet for this article.
January 18, 2018: Nature Immunology
https://www.readbyqxmd.com/read/29348500/myeloid-derived-suppressor-cells-coming-of-age
#18
REVIEW
Filippo Veglia, Michela Perego, Dmitry Gabrilovich
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells generated during a large array of pathologic conditions ranging from cancer to obesity. These cells represent a pathologic state of activation of monocytes and relatively immature neutrophils. MDSCs are characterized by a distinct set of genomic and biochemical features, and can, on the basis of recent findings, be distinguished by specific surface molecules. The salient feature of these cells is their ability to inhibit T cell function and thus contribute to the pathogenesis of various diseases...
January 18, 2018: Nature Immunology
https://www.readbyqxmd.com/read/29348499/eradp-standing-in-the-shadow-of-sting-innate-immune-signaling
#19
Martin Roelsgaard Jakobsen
No abstract text is available yet for this article.
January 18, 2018: Nature Immunology
https://www.readbyqxmd.com/read/29348497/rna-binding-proteins-control-gene-expression-and-cell-fate-in-the-immune-system
#20
REVIEW
Martin Turner, Manuel D Díaz-Muñoz
RNA-binding proteins (RBPs) are essential for the development and function of the immune system. They interact dynamically with RNA to control its biogenesis and turnover by transcription-dependent and transcription-independent mechanisms. In this Review, we discuss the molecular mechanisms by which RBPs allow gene expression changes to occur at different speeds and to varying degrees, and which RBPs regulate the diversity of the transcriptome and proteome. These proteins are nodes for integration of transcriptional and signaling networks and are intimately linked to intermediary metabolism...
January 18, 2018: Nature Immunology
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