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Josephine Kemna, Evelyne Gout, Leon Daniau, Jessica Lao, Kristoffer Weißert, Sandra Ammann, Ralf Kühn, Matthias Richter, Christine Molenda, Anje Sporbert, Dario Zocholl, Robert Klopfleisch, Anja Schütz, Hugues Lortat-Jacob, Peter Aichele, Thomas Kammertoens, Thomas Blankenstein
No abstract text is available yet for this article.
April 19, 2024: Nature Immunology
#2
Joey H Li, Adalia Zhou, Cassidy D Lee, Siya N Shah, Jeong Hyun Ji, Vignesh Senthilkumar, Eddie T Padilla, Andréa B Ball, Qinyan Feng, Christian G Bustillos, Luke Riggan, Alain Greige, Ajit S Divakaruni, Fran Annese, Jessica A Cooley Coleman, Steven A Skinner, Christopher W Cowan, Timothy E O'Sullivan
No abstract text is available yet for this article.
April 19, 2024: Nature Immunology
#3
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
April 19, 2024: Nature Immunology
#4
JOURNAL ARTICLE
Ivan Zanoni
No abstract text is available yet for this article.
April 19, 2024: Nature Immunology
#5
JOURNAL ARTICLE
Jingwen Liao, Diana C Hargreaves
No abstract text is available yet for this article.
April 19, 2024: Nature Immunology
#6
JOURNAL ARTICLE
Meredith L Stone, Jesse Lee, Jae W Lee, Heather Coho, Mito Tariveranmoshabad, Max M Wattenberg, Hana Choi, Veronica M Herrera, Yuqing Xue, Shaanti Choi-Bose, Sofia K Zingone, Dhruv Patel, Kelly Markowitz, Devora Delman, Vinod P Balachandran, Gregory L Beatty
T cell infiltration into tumors is a favorable prognostic feature, but most solid tumors lack productive T cell responses. Mechanisms that coordinate T cell exclusion are incompletely understood. Here we identify hepatocyte activation via interleukin-6/STAT3 and secretion of serum amyloid A (SAA) proteins 1 and 2 as important regulators of T cell surveillance of extrahepatic tumors. Loss of STAT3 in hepatocytes or SAA remodeled the tumor microenvironment with infiltration by CD8+ T cells, while interleukin-6 overexpression in hepatocytes and SAA signaling via Toll-like receptor 2 reduced the number of intratumoral dendritic cells and, in doing so, inhibited T cell tumor infiltration...
April 19, 2024: Nature Immunology
#7
JOURNAL ARTICLE
Pamela Wong, Todd A Fehniger
No abstract text is available yet for this article.
April 18, 2024: Nature Immunology
#8
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
April 17, 2024: Nature Immunology
#9
JOURNAL ARTICLE
Noah Gamble, Alexandra Bradu, Jason A Caldwell, Joshua McKeever, Olubusayo Bolonduro, Ebru Ermis, Caroline Kaiser, YeEun Kim, Benjamin Parks, Sandy Klemm, William J Greenleaf, Gerald R Crabtree, Andrew S Koh
Adaptive immunity relies on specialized effector functions elicited by lymphocytes, yet how antigen recognition activates appropriate effector responses through nonspecific signaling intermediates is unclear. Here we examined the role of chromatin priming in specifying the functional outputs of effector T cells and found that most of the cis-regulatory landscape active in effector T cells was poised early in development before the expression of the T cell antigen receptor. We identified two principal mechanisms underpinning this poised landscape: the recruitment of the nucleosome remodeler mammalian SWItch/Sucrose Non-Fermentable (mSWI/SNF) by the transcription factors RUNX1 and PU...
April 17, 2024: Nature Immunology
#10
JOURNAL ARTICLE
Marisol Alvarez-Martinez, Luke S Cox, Claire F Pearson, William J Branchett, Probir Chakravarty, Xuemei Wu, Hubert Slawinski, Alaa Al-Dibouni, Vasileios A Samelis, Leona Gabryšová, Simon L Priestnall, Alejandro Suárez-Bonnet, Anna Mikolajczak, James Briscoe, Fiona Powrie, Anne O'Garra
Intestinal immune responses to microbes are controlled by the cytokine IL-10 to avoid immune pathology. Here, we use single-cell RNA sequencing of colon lamina propria leukocytes (LPLs) along with RNA-seq and ATAC-seq of purified CD4+ T cells to show that the transcription factors Blimp-1 (encoded by Prdm1) and c-Maf co-dominantly regulate Il10 while negatively regulating proinflammatory cytokines in effector T cells. Double-deficient Prdm1fl/fl Maffl/fl Cd4Cre mice infected with Helicobacter hepaticus developed severe colitis with an increase in TH 1/NK/ILC1 effector genes in LPLs, while Prdm1fl/fl Cd4Cre and Maffl/fl Cd4Cre mice exhibited moderate pathology and a less-marked type 1 effector response...
April 12, 2024: Nature Immunology
#11
JOURNAL ARTICLE
Hirotsugu Oda, Kalpana Manthiram, Pallavi Pimpale Chavan, Eva Rieser, Önay Veli, Öykü Kaya, Charles Rauch, Shuichiro Nakabo, Hye Sun Kuehn, Mariël Swart, Yanli Wang, Nisa Ilgim Çelik, Anne Molitor, Vahid Ziaee, Nasim Movahedi, Mohammad Shahrooei, Nima Parvaneh, Nasrin Alipour-Olyei, Raphael Carapito, Qin Xu, Silvia Preite, David B Beck, Jae Jin Chae, Michele Nehrebecky, Amanda K Ombrello, Patrycja Hoffmann, Tina Romeo, Natalie T Deuitch, Brynja Matthíasardóttir, James Mullikin, Hirsh Komarow, Jennifer Stoddard, Julie Niemela, Kerry Dobbs, Colin L Sweeney, Holly Anderton, Kate E Lawlor, Hiroyuki Yoshitomi, Dan Yang, Manfred Boehm, Jeremy Davis, Pamela Mudd, Davide Randazzo, Wanxia Li Tsai, Massimo Gadina, Mariana J Kaplan, Junya Toguchida, Christian T Mayer, Sergio D Rosenzweig, Luigi D Notarangelo, Kazuhiro Iwai, John Silke, Pamela L Schwartzberg, Bertrand Boisson, Jean-Laurent Casanova, Seiamak Bahram, Anand Prahalad Rao, Nieves Peltzer, Henning Walczak, Najoua Lalaoui, Ivona Aksentijevich, Daniel L Kastner
The linear ubiquitin assembly complex (LUBAC) consists of HOIP, HOIL-1 and SHARPIN and is essential for proper immune responses. Individuals with HOIP and HOIL-1 deficiencies present with severe immunodeficiency, autoinflammation and glycogen storage disease. In mice, the loss of Sharpin leads to severe dermatitis due to excessive keratinocyte cell death. Here, we report two individuals with SHARPIN deficiency who manifest autoinflammatory symptoms but unexpectedly no dermatological problems. Fibroblasts and B cells from these individuals showed attenuated canonical NF-κB responses and a propensity for cell death mediated by TNF superfamily members...
April 12, 2024: Nature Immunology
#12
Neal N Iwakoshi, Ann-Hwee Lee, Prasanth Vallabhajosyula, Kevin L Otipoby, Klaus Rajewsky, Laurie H Glimcher
No abstract text is available yet for this article.
April 10, 2024: Nature Immunology
#13
JOURNAL ARTICLE
Daniela Cerezo-Wallis, Iván Ballesteros
No abstract text is available yet for this article.
April 10, 2024: Nature Immunology
#14
JOURNAL ARTICLE
Madelon M E de Jong, Cathelijne Fokkema, Natalie Papazian, Ágnes Czeti, Marjolein K Appelman, Michael Vermeulen, Teddie van Heusden, Remco M Hoogenboezem, Gregory van Beek, Sabrin Tahri, Mathijs A Sanders, Pieter C van de Woestijne, Francesca Gay, Philippe Moreau, Maike Büttner-Herold, Heiko Bruns, Mark van Duin, Annemiek Broijl, Pieter Sonneveld, Tom Cupedo
Human bone marrow permanently harbors high numbers of neutrophils, and a tumor-supportive bias of these cells could significantly impact bone marrow-confined malignancies. In individuals with multiple myeloma, the bone marrow is characterized by inflammatory stromal cells with the potential to influence neutrophils. We investigated myeloma-associated alterations in human marrow neutrophils and the impact of stromal inflammation on neutrophil function. Mature neutrophils in myeloma marrow are activated and tumor supportive and transcribe increased levels of IL1B and myeloma cell survival factor TNFSF13B (BAFF)...
April 10, 2024: Nature Immunology
#15
JOURNAL ARTICLE
Joey H Li, Adalia Zhou, Cassidy D Lee, Siya N Shah, Jeong Hyun Ji, Vignesh Senthilkumar, Eddie T Padilla, Andréa B Ball, Qinyan Feng, Christian G Bustillos, Luke Riggan, Alain Greige, Ajit S Divakaruni, Fran Annese, Jessica Cooley-Coleman, Steven A Skinner, Christopher W Cowan, Timothy E O'Sullivan
Natural killer (NK) cells are a critical first line of defense against viral infection. Rare mutations in a small subset of transcription factors can result in decreased NK cell numbers and function in humans, with an associated increased susceptibility to viral infection. However, our understanding of the specific transcription factors governing mature human NK cell function is limited. Here we use a non-viral CRISPR-Cas9 knockout screen targeting genes encoding 31 transcription factors differentially expressed during human NK cell development...
April 8, 2024: Nature Immunology
#16
JOURNAL ARTICLE
Radomir Kratchmarov, Sarah Djeddi, Garrett Dunlap, Wenqin He, Xiaojiong Jia, Caitlin M Burk, Tessa Ryan, Alanna McGill, Jessica R Allegretti, Raghu P Kataru, Babak J Mehrara, Erin M Taylor, Shailesh Agarwal, Neil Bhattacharyya, Regan W Bergmark, Alice Z Maxfield, Stella Lee, Rachel Roditi, Daniel F Dwyer, Joshua A Boyce, Kathleen M Buchheit, Tanya M Laidlaw, Wayne G Shreffler, Deepak A Rao, Maria Gutierrez-Arcelus, Patrick J Brennan
Repetitive exposure to antigen in chronic infection and cancer drives T cell exhaustion, limiting adaptive immunity. In contrast, aberrant, sustained T cell responses can persist over decades in human allergic disease. To understand these divergent outcomes, we employed bioinformatic, immunophenotyping and functional approaches with human diseased tissues, identifying an abundant population of type 2 helper T (TH 2) cells with co-expression of TCF7 and LEF1, and features of chronic activation. These cells, which we termed TH 2-multipotent progenitors (TH 2-MPP) could self-renew and differentiate into cytokine-producing effector cells, regulatory T (Treg ) cells and follicular helper T (TFH ) cells...
April 8, 2024: Nature Immunology
#17
REVIEW
Eunha Kim, Jun R Huh, Gloria B Choi
The intricate relationship between immune dysregulation and neurodevelopmental disorders (NDDs) has been observed across the stages of both prenatal and postnatal development. In this Review, we provide a comprehensive overview of various maternal immune conditions, ranging from infections to chronic inflammatory conditions, that impact the neurodevelopment of the fetus during pregnancy. Furthermore, we examine the presence of immunological phenotypes, such as immune-related markers and coexisting immunological disorders, in individuals with NDDs...
April 2, 2024: Nature Immunology
#18
JOURNAL ARTICLE
Stephanie Houston
No abstract text is available yet for this article.
April 2, 2024: Nature Immunology
#19
JOURNAL ARTICLE
Megat H B A Hamid, Pablo F Cespedes, Chen Jin, Ji-Li Chen, Uzi Gileadi, Elie Antoun, Zhu Liang, Fei Gao, Renuka Teague, Nikita Manoharan, David Maldonado-Perez, Nasullah Khalid-Alham, Lucia Cerundolo, Raul Ciaoca, Svenja S Hester, Adán Pinto-Fernández, Simeon D Draganov, Iolanda Vendrell, Guihai Liu, Xuan Yao, Audun Kvalvaag, Delaney C C Dominey-Foy, Charunya Nanayakkara, Nikolaos Kanellakis, Yi-Ling Chen, Craig Waugh, Sally-Ann Clark, Kevin Clark, Paul Sopp, Najib M Rahman, Clare Verrill, Benedikt M Kessler, Graham Ogg, Ricardo A Fernandes, Roman Fisher, Yanchun Peng, Michael L Dustin, Tao Dong
Cancer remains one of the leading causes of mortality worldwide, leading to increased interest in utilizing immunotherapy strategies for better cancer treatments. In the past decade, CD103+ T cells have been associated with better clinical prognosis in patients with cancer. However, the specific immune mechanisms contributing toward CD103-mediated protective immunity remain unclear. Here, we show an unexpected and transient CD61 expression, which is paired with CD103 at the synaptic microclusters of T cells...
April 1, 2024: Nature Immunology
#20
JOURNAL ARTICLE
Hannah F Bradford, Thomas C R McDonnell, Alexander Stewart, Andrew Skelton, Joseph Ng, Zara Baig, Franca Fraternali, Deborah Dunn-Walters, David A Isenberg, Adnan R Khan, Claudio Mauro, Claudia Mauri
Metabolic programming is important for B cell fate, but the bioenergetic requirement for regulatory B (Breg ) cell differentiation and function is unknown. Here we show that Breg cell differentiation, unlike non-Breg cells, relies on mitochondrial electron transport and homeostatic levels of reactive oxygen species (ROS). Single-cell RNA sequencing analysis revealed that TXN, encoding the metabolic redox protein thioredoxin (Trx), is highly expressed by Breg cells, unlike Trx inhibitor TXNIP which was downregulated...
March 29, 2024: Nature Immunology
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