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Journal of Headache and Pain

Adina Bathel, Lauren Schweizer, Philipp Stude, Benjamin Glaubitz, Niklas Wulms, Sibel Delice, Tobias Schmidt-Wilcke
BACKGROUND: Increased cortical excitability has been hypothesized to play a critical role in various neurological disorders, such as restless legs syndrome, epilepsy and migraine. Particularly for migraine, local hyperexcitability has been reported. Levels of regional excitatory and inhibitory neurotransmitters are related to cortical excitability and hence may play a role in the origin of the disease. Consequently, a mismatch of the excitatory-inhibitory neurotransmitter network might contribute to local hyperexcitability and the onset of migraine attacks...
July 17, 2018: Journal of Headache and Pain
Ching-I Hung, Chia-Yih Liu, Ching-Hui Yang, Shuu-Jiun Wang
BACKGROUND: No study has investigated the associations of migraine with pain symptoms over a ten-year period among outpatients with major depressive disorder (MDD). This study aimed to investigate this issue. METHODS: At baseline, the study enrolled 290 outpatients with MDD and followed-up the patients at six-month, two-year, and ten-year time points. MDD and anxiety comorbidities were diagnosed using the Structured Clinical Interview for DSM-IV-text revision. Migraine was diagnosed based on the International Classification of Headache Disorders...
July 17, 2018: Journal of Headache and Pain
Jong-Hee Sohn, Min-Kyung Chu, Kwang-Yeol Park, Hong-Yup Ahn, Soo-Jin Cho
BACKGROUND: Cluster headache is famous for attacks with seasonal and diurnal periodicity. This diurnal and seasonal variation might be related to sunlight and vitamin D metabolism. We investigated the serum vitamin D levels in patients with cluster headache. METHODS: We enrolled patients with cluster headache and age- and sex-matched migraineurs and normal controls. From October 2016 to March 2018, non-fasting serum 25(OH)D concentrations were measured using a chemiluminescent immunoassay...
July 17, 2018: Journal of Headache and Pain
Mi Ji Lee, Sook-Yeon Lee, Soohyun Cho, Eun-Suk Kang, Chin-Sang Chung
BACKGROUND: Calcitonin gene-related peptide (CGRP) has been reported as elevated in chronic migraine. We aimed to validate the role of interictal serum CGRP concentration in peripheral blood samples as a biomarker of chronic migraine. METHODS: We prospectively recruited patients with episodic and chronic migraine and normal controls (NCs) in the Samsung Medical Center between August 2015 and May 2016. Blood samples were collected interictally from antecubital veins per prespecified protocol...
July 13, 2018: Journal of Headache and Pain
Iman Dianat, Arezou Alipour, Mohammad Asghari Jafarabadi
BACKGROUND: To investigate the combinations of Musculoskeletal pain (MSP) (neck, shoulder, upper and low back pain) among a sample of Iranian school children. METHODS: The MSP combinations was modeled by latent class analysis (LCA) to find the clusters of high-risk individuals and multigroup LCA taking into account the gender and age (≤ 13 years and ≥ 14 years of age categories). RESULTS: The lowest and highest prevalence of MSP was 14...
July 13, 2018: Journal of Headache and Pain
Nicolas Vandenbussche, Domenico Laterza, Marco Lisicki, Joseph Lloyd, Chiara Lupi, Hannes Tischler, Kati Toom, Fenne Vandervorst, Simone Quintana, Koen Paemeleire, Zaza Katsarava
Medication overuse in primary headache disorders is a worldwide phenomenon and has a role in the chronification of headache disorders. The burden of disease on individuals and societies is significant due to high costs and comorbidities. In the Third Edition of the International Classification of Headache Disorders, medication-overuse headache is recognized as a separate secondary entity next to mostly primary headache disorders, although many clinicians see the disease as a sole complication of primary headache disorders...
July 13, 2018: Journal of Headache and Pain
Rosaria Greco, Chiara Demartini, Anna Maria Zanaboni, Cristina Tassorelli
BACKGROUND: Calcitonin gene related peptide (CGRP) is a key neuropeptide involved in the activation of the trigeminovascular system and it is likely related to migraine chronification. Here, we investigated the role of CGRP in an animal model that mimics the chronic migraine condition via repeated and intermittent nitroglycerin (NTG) administration. We also evaluated the modulatory effect of topiramate on this experimental paradigm. Male Sprague-Dawley rats were injected with NTG (5 mg/kg, i...
July 13, 2018: Journal of Headache and Pain
Marco Lisicki, Kevin D'Ostilio, Gianluca Coppola, Felix Scholtes, Alain Maertens de Noordhout, Vincenzo Parisi, Jean Schoenen, Delphine Magis
BACKGROUND: Migraine attacks might be triggered by a disruption of cerebral homeostasis. During the interictal period migraine patients are characterized by abnormal sensory information processing, but this functional abnormality may not be sufficient to disrupt the physiological equilibrium of the cortex unless it is accompanied by additional pathological mechanisms, like a reduction in energetic reserves. The aim of this study was to compare resting cerebral glucose uptake (using positron emission tomography (18 fluorodeoxyglucose-PET)), and visual cortex activation (using visual evoked potentials (VEP)), between episodic migraine without aura patients in the interictal period and healthy volunteers...
July 5, 2018: Journal of Headache and Pain
Kerstin Luedtke, Waclaw Adamczyk, Katrin Mehrtens, Inken Moeller, Louisa Rosenbaum, Axel Schaefer, Janine Schroeder, Tibor Szikszay, Christian Zimmer, Bettina Wollesen
BACKGROUND: Chronic pain including migraine is associated with structural and functional changes in the somatosensory cortex. Previous reports proposed two-point discrimination (TPD) as a measurement for cortical alterations. Limited evidence exists for tactile acuity in the neck and no data is available for migraine. METHODS: To introduce a standardized protocol for the measurement of TPD in the upper cervical spine, 51 healthy participants were investigated with a newly developed paradigm which was evaluated for intra-rater reliability...
June 26, 2018: Journal of Headache and Pain
Mengmeng Ma, Junran Zhang, Ning Chen, Jian Guo, Yang Zhang, Li He
BACKGROUND: Major depressive disorder is a common comorbidity in migraineurs. Depression may affect the progression and prognosis of migraine. Few studies have examined the brain function in migraineurs that may cause this comorbidity. Here, we aimed to explore depression-related abnormalities in the intrinsic brain activity of interictal migraineurs with comorbid depression using resting-state functional magnetic resonance imaging. RESULTS: Significant main effects of migraine and depression provided evidence that migraine and depression jointly affected the left medial prefrontal cortex, which was thought to be the neural basis of self-referential mental activity in previous studies...
June 26, 2018: Journal of Headache and Pain
Junpeng Liu, Jiajia Zhu, Fei Yuan, Xuejun Zhang, Quan Zhang
BACKGROUND: Idiopathic or classical trigeminal neuralgia (TN) is a chronic painful condition characterized by intermittent pain attacks. Enough evidence demonstrates classical TN is related to neurovascular compression (NVC) at the trigeminal root entry zone (REZ), but white matter change secondary to TN are not totally known. METHODS: Visual Analogue Scale (VAS) and diffusion tensor imaging were performed on 29 patients with right TN and 35 healthy individuals...
June 22, 2018: Journal of Headache and Pain
Christian Lampl, Mirjam Rudolph, Elisabeth Bräutigam
BACKGROUND: Cluster headache (CH) is a clinically well-defined primary headache disorder, approximately 20% of cluster headache sufferers experience recurrent attacks without periods of significant remission. For the treatment of chronic cluster headache (CCH) only limited therapeutic options are available. METHODS: A potential refractory CCH patient group was identified according to the clinical definition of rCCH based on the consensus statement of the European Headache Federation (EHF)...
June 19, 2018: Journal of Headache and Pain
Samaira Younis, Anders Hougaard, Casper Emil Christensen, Mark Bitsch Vestergaard, Esben Thade Petersen, Olaf Bjarne Paulson, Henrik Bo Wiberg Larsson, Messoud Ashina
BACKGROUND: Studies involving human pharmacological migraine models have predominantly focused on the vasoactive effects of headache-inducing drugs, including sildenafil and calcitonin gene-related peptide (CGRP). However, the role of possible glutamate level changes in the brainstem and thalamus is of emerging interest in the field of migraine research bringing forth the need for a novel, validated method to study the biochemical effects in these areas. METHODS: We applied an optimized in vivo human pharmacological proton (1 H) magnetic resonance spectroscopy (MRS) protocol (PRESS, repetition time 3000 ms, echo time 37...
June 18, 2018: Journal of Headache and Pain
Alexei A Kamshilin, Maxim A Volynsky, Olga Khayrutdinova, Dilyara Nurkhametova, Laura Babayan, Alexander V Amelin, Oleg V Mamontov, Rashid Giniatullin
BACKGROUND: The non-invasive biomarkers of migraine can help to develop the personalized medication of this disorder. In testing of the antimigraine drugs the capsaicin-induced skin redness with activated TRPV1 receptors in sensory neurons associated with the release of the migraine mediator CGRP has already been widely used. METHODS: Fourteen migraine patients (mean age 34.6 ± 10.2 years) and 14 healthy volunteers (mean age 29.9 ± 9.7 years) participated in the experiment...
June 18, 2018: Journal of Headache and Pain
Huimin Tao, Teng Wang, Xin Dong, Qi Guo, Huan Xu, Qi Wan
BACKGROUND: Migraine is now ranked as the second most disabling disorder worldwide reported by the Global Burden of Disease Study 2016. As a noninvasive neurostimulation technique, transcutaneous electrical nerve stimulation(TENS) has been applied as an abortive and prophylactic treatment for migraine recently. We conduct this meta-analysis to analyze the effectiveness and safety of TENS on migraineurs. METHODS: We searched Medline (via PubMed), Embase, the Cochrane Library and the Cochrane Central Register of Controlled Trials to identify randomized controlled trials, which compared the effect of TENS with sham TENS on migraineurs...
May 29, 2018: Journal of Headache and Pain
Abimael González-Hernández, Jair Lozano-Cuenca, Bruno A Marichal-Cancino, Antoinette MaassenVanDenBrink, Carlos M Villalón
BACKGROUND: Dihydroergotamine (DHE) is an antimigraine drug that produces cranial vasoconstriction and inhibits trigeminal CGRP release; furthermore, it inhibits the vasodepressor sensory CGRPergic outflow, but the receptors involved remain unknown. Prejunctional activation of α2A/2C -adrenergic, serotonin 5-HT1B/1F , or dopamine D2 -like receptors results in inhibition of this CGRPergic outflow. Since DHE displays affinity for these receptors, this study investigated the pharmacological profile of DHE-induced inhibition of the vasodepressor sensory CGRPergic outflow...
May 25, 2018: Journal of Headache and Pain
Louise S Mose, Susanne S Pedersen, Birgit Debrabant, Rigmor H Jensen, Bibi Gram
BACKGROUND: Factors associated with development of medication-overuse headache (MOH) in migraine patients are not fully understood, but with respect to prevention, the ability to predict the onset of MOH is clinically important. The aims were to examine if personality characteristics, disability and physical activity level are associated with the onset of MOH in a group of migraine patients and explore to which extend these factors combined can predict the onset of MOH. METHODS: The study was a single-center prospective observational study of migraine patients...
May 25, 2018: Journal of Headache and Pain
Kristian A Haanes, Alejandro Labastida-Ramírez, Kayi Y Chan, René de Vries, Brian Shook, Paul Jackson, Jimmy Zhang, Christopher M Flores, Alexander H J Danser, Carlos M Villalón, Antoinette MaassenVanDenBrink
BACKGROUND: Migraine is considered a neurovascular disorder, but its pathophysiological mechanisms are not yet fully understood. Adenosine has been shown to increase in plasma during migraine attacks and to induce vasodilation in several blood vessels; however, it remains unknown whether adenosine can interact with the trigeminovascular system. Moreover, caffeine, a non-selective adenosine receptor antagonist, is included in many over the counter anti-headache/migraine treatments. METHODS: This study used the rat closed cranial window method to investigate in vivo the effects of the adenosine A2A receptor antagonists with varying selectivity over A1 receptors; JNJ-39928122, JNJ-40529749, JNJ-41942914, JNJ-40064440 or JNJ-41501798 (0...
May 25, 2018: Journal of Headache and Pain
Eric P Baron, Philippe Lucas, Joshua Eades, Olivia Hogue
BACKGROUND: Medicinal cannabis registries typically report pain as the most common reason for use. It would be clinically useful to identify patterns of cannabis treatment in migraine and headache, as compared to arthritis and chronic pain, and to analyze preferred cannabis strains, biochemical profiles, and prescription medication substitutions with cannabis. METHODS: Via electronic survey in medicinal cannabis patients with headache, arthritis, and chronic pain, demographics and patterns of cannabis use including methods, frequency, quantity, preferred strains, cannabinoid and terpene profiles, and prescription substitutions were recorded...
May 24, 2018: Journal of Headache and Pain
Todd J Schwedt, Aftab Alam, Michael L Reed, Kristina M Fanning, Sagar Munjal, Dawn C Buse, David W Dodick, Richard B Lipton
BACKGROUND: The MAST Study is a longitudinal, cross-sectional survey study of US adults with migraine. These analyses were conducted to estimate rates of acute medication overuse (AMO) and determine associations of AMO with individual and headache characteristics. METHODS: Eligible respondents had ICHD-3-beta migraine, reported ≥3 monthly headache days (MHDs) in the past 3 months, ≥1 MHD in the past 30 days, and currently took acute headache medication. AMO was defined according to ICHD-3-beta thresholds for monthly days of medication taking when diagnosing medication overuse headache...
May 24, 2018: Journal of Headache and Pain
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