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Journal of Headache and Pain

D García-Azorin, N Yamani, L M Messina, I Peeters, M Ferrili, D Ovchinnikov, M L Speranza, V Marini, A Negro, S Benemei, M Barloese
BACKGROUND: Primary headache are prevalent and debilitating disorders. Acute pain cessation is one of the key points in their treatment. Many drugs have been studied but the design of the trials is not usually homogeneous. Efficacy of the trial is determined depending on the selected primary endpoint and usually other different outcomes are measured. We aim to critically appraise which were the employed outcomes through a systematic review. METHODS: We conducted a systematic review of literature focusing on studies on primary headache evaluating acute relief of pain, following the PRISMA guideline...
September 21, 2018: Journal of Headache and Pain
Anne Luise Vollesen, Silvia Benemei, Francesca Cortese, Alejandro Labastida-Ramírez, Francesca Marchese, Lanfranco Pellesi, Michele Romoli, Messoud Ashina, Christian Lampl
Although clinically distinguishable, migraine and cluster headache share prominent features such as unilateral pain, common pharmacological triggers such glyceryl trinitrate, histamine, calcitonin gene-related peptide (CGRP) and response to triptans and neuromodulation. Recent data also suggest efficacy of anti CGRP monoclonal antibodies in both migraine and cluster headache. While exact mechanisms behind both disorders remain to be fully understood, the trigeminovascular system represents one possible common pathophysiological pathway and network of both disorders...
September 21, 2018: Journal of Headache and Pain
Amal Al-Khotani, Mattias Gjelset, Aron Naimi-Akbar, Britt Hedenberg-Magnusson, Malin Ernberg, Nikolaos Christidis
BACKGROUND: Since children and adolescents are frequently experiencing emotional and behavioral consequences due to pain, their parents should be aware of this emotional and behavioral status. Therefore, the aim of this study was to analyze and describe the parents' reports of the emotional and behavioral status of children and adolescents with different types of temporomandibular disorders using the Child Behavior Checklist. METHODS: This Cross-sectional study comprises of 386 randomly selected children and adolescents that ages between 10 and 18 years in Jeddah...
September 21, 2018: Journal of Headache and Pain
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No abstract text is available yet for this article.
September 20, 2018: Journal of Headache and Pain
Michail Vikelis, Andreas A Argyriou, Emmanouil V Dermitzakis, Konstantinos C Spingos, Nikolaos Makris, Evangelia Kararizou
BACKGROUND: Evidence on whether the therapeutic effect and good safety profile of onabotulinumtoxinA (Botox®) in chronic migraine (CM) patients is maintained over long term treatment is still limited. We herein aimed at assessing whether there is a sustained benefit and good safety with repeated onabotulinumtoxinA sessions in CM over more than three years of treatment. METHODS: We prospectively enrolled 65 CM patients, who were classified as responders after three sessions of onabotulinumtoxinA and were eligible to further continue treatment...
September 17, 2018: Journal of Headache and Pain
Jiyoung Kim, Soo-Jin Cho, Won-Joo Kim, Kwang Ik Yang, Chang-Ho Yun, Min Kyung Chu
BACKGROUND: Insomnia and migraine are closely related; insomnia aggravates migraine symptoms. This study was conducted to investigate the impact of migraine on the clinical presentation of insomnia symptoms. METHODS: The data of the Korean Headache-Sleep Study (KHSS) were used in the present study. The KHSS is a nation-wide cross-sectional population-based survey regarding headache and sleep in Korean adults aged 19 to 69 years. If a participant's Insomnia Severity Index (ISI) score ≥ 10, she/he was classified as having insomnia...
September 14, 2018: Journal of Headache and Pain
Thien Phu Do, Gerda Ferja Heldarskard, Lærke Tørring Kolding, Jeppe Hvedstrup, Henrik Winther Schytz
BACKGROUND: A myofascial trigger point is defined as a hyperirritable spot in skeletal muscle that is associated with a hypersensitive palpable nodule in a taut band. It has been suggested that myofascial trigger points take part in chronic pain conditions including primary headache disorders. The aim of this narrative review is to present an overview of the current imaging modalities used for the detection of myofascial trigger points and to review studies of myofascial trigger points in migraine and tension-type headache...
September 10, 2018: Journal of Headache and Pain
Simona Sacco, Gabriele S Merki-Feld, Karen Lehrmann Ægidius, Johannes Bitzer, Marianne Canonico, Tobias Kurth, Christian Lampl, Øjvind Lidegaard, E Anne MacGregor, Antoinette MaassenVanDenBrink, Dimos-Dimitrios Mitsikostas, Rossella Elena Nappi, George Ntaios, Per Morten Sandset, Paolo Martelletti
Following the publication of this article [1], the authors noticed that they incorrectly reported the Absolute risk of ischemic stroke in women aged 20 to 44 years in relation to the use of hormonal contraception and migraine status due to a miscalculation. They apologize for this misreported result.
September 10, 2018: Journal of Headache and Pain
Alberto Raggi, Venusia Covelli, Erika Guastafierro, Matilde Leonardi, Chiara Scaratti, Licia Grazzi, Marco Bartolini, Giovanna Viticchi, Sabina Cevoli, Giulia Pierangeli, Gioacchino Tedeschi, Antonio Russo, Piero Barbanti, Cinzia Aurilia, Carlo Lovati, Luca Giani, Fabio Frediani, Paola Di Fiore, Francesco Bono, Laura Rapisarda, Domenico D'Amico
BACKGROUND: The degree to which work-related difficulties are recognized in headache research is poor and often carried out with inadequate information such as "reduced ability to work as usual", which do not capture at all the variety of difficulties and the factors that impact over them. The aim of this paper is to present the validation of the HEADWORK questionnaire, which addresses the amount and severity of difficulties in work-related tasks and the factors that impact over them...
September 10, 2018: Journal of Headache and Pain
Faisal Mohammad Amin, Stavroula Aristeidou, Carlo Baraldi, Ewa K Czapinska-Ciepiela, Daponte D Ariadni, Davide Di Lenola, Cherilyn Fenech, Konstantinos Kampouris, Giorgos Karagiorgis, Mark Braschinsky, Mattias Linde
BACKGROUND: There is an unmet need of pharmacological and non-pharmacological treatment options for migraine patients. Exercise can be used in the treatment of several pain conditions, including. However, what exact role exercise plays in migraine prevention is unclear. Here, we review the associations between physical exercise and migraine from an epidemiological, therapeutical and pathophysiological perspective. METHODS: The review was based on a primary literature search on the PubMed using the search terms "migraine and exercise"...
September 10, 2018: Journal of Headache and Pain
Pamela Vo, Juanzhi Fang, Aikaterini Bilitou, Annik K Laflamme, Shaloo Gupta
BACKGROUND: Migraine is a distinct neurological disease that imposes a significant burden on patients, society, and the healthcare system. This study aimed to characterize the incremental burden of migraine in individuals who suffer from ≥4 monthly headache days (MHDs) by examining health-related quality of life (HRQoL), impairments to work productivity and daily activities, and healthcare resource utilization (HRU) in the EU5 (France, Germany, Italy, Spain, United Kingdom). METHODS: This retrospective cross-sectional study used data from the 2016 National Health and Wellness Survey (NHWS; N = 80,600)...
September 10, 2018: Journal of Headache and Pain
Bo Larsson, Johannes Foss Sigurdson, Anne Mari Sund
BACKGROUND: Several outcome studies have reported on the short- and long-term effects of migraine in selected clinical samples of children and adolescents. However, current knowledge of the course, incidence, and outcome predictors of frequent headaches in early adolescents in community populations is limited, and little is known about the long-term effects. Headache remains untreated in most of these young people. Here we examined the course, incidence, and outcome predictors of frequent headaches (at least once a week) over the long term (14 years) using previously assessed data at the baseline and 1-year follow-up of early adolescents...
September 4, 2018: Journal of Headache and Pain
Yun-Ju Choi, Byung-Kun Kim, Pil-Wook Chung, Mi Ji Lee, Jung-Wook Park, Min Kyung Chu, Jin-Young Ahn, Byung-Su Kim, Tae-Jin Song, Jong-Hee Sohn, Kyungmi Oh, Kwang-Soo Lee, Soo-Kyoung Kim, Kwang-Yeol Park, Jae Myun Chung, Heui-Soo Moon, Chin-Sang Chung, Soo-Jin Cho
BACKGROUND: Cluster headaches (CH) are recurrent severe headaches, which impose a major burden on the life of patients. We investigated the impact of CH on employment status and job burden. METHODS: The study was a sub-study of the Korean Cluster Headache Registry. Patients with CH were enrolled from September 2016 to February 2018 from 15 headache clinics in Korea. We also enrolled a headache control group with age-sex matched patients with migraine or tension-type headache...
September 3, 2018: Journal of Headache and Pain
Simona Sacco, Gabriele S Merki-Feld, Karen Lehrmann Ægidius, Johannes Bitzer, Marianne Canonico, Andreas R Gantenbein, Tobias Kurth, Christian Lampl, Øjvind Lidegaard, E Anne MacGregor, Antoinette MaassenVanDenBrink, Dimos-Dimitrios Mitsikostas, Rossella Elena Nappi, George Ntaios, Koen Paemeleire, Per Morten Sandset, Gisela Marie Terwindt, Kjersti Grøtta Vetvik, Paolo Martelletti
We systematically reviewed data about the effect of exogenous estrogens and progestogens on the course of migraine during reproductive age. Thereafter a consensus procedure among international experts was undertaken to develop statements to support clinical decision making, in terms of possible effects on migraine course of exogenous estrogens and progestogens and on possible treatment of headache associated with the use or with the withdrawal of hormones. Overall, quality of current evidence is low. Recommendations are provided for all the compounds with available evidence including the conventional 21/7 combined hormonal contraception, the desogestrel only oral pill, combined oral contraceptives with shortened pill-free interval, combined oral contraceptives with estradiol supplementation during the pill-free interval, extended regimen of combined hormonal contraceptive with pill or patch, combined hormonal contraceptive vaginal ring, transdermal estradiol supplementation with gel, transdermal estradiol supplementation with patch, subcutaneous estrogen implant with cyclical oral progestogen...
August 31, 2018: Journal of Headache and Pain
Michele Viana, Grazia Sances, Mattias Linde, Giuseppe Nappi, Farihah Khaliq, Peter J Goadsby, Cristina Tassorelli
BACKGROUND: There is limited literature on prolonged aura (PA - defined as an aura including at least one symptom for > 1 h and < 7d), and there are no prospective studies. The aim of this study is to characterize prospectively the phenotype and prevalence of PA. FINDINGS: Two hundred and twenty-four patients suffering from migraine with aura were recruited from the Headache Centers of Pavia and Trondheim. Patients prospectively described, on an ad hoc diary, each aura symptom (AS), the duration of AS and headache, and headache features...
August 31, 2018: Journal of Headache and Pain
G S Grieco, S Gagliardi, I Ricca, O Pansarasa, M Neri, F Gualandi, G Nappi, A Ferlini, C Cereda
BACKGROUND: Familial hemiplegic migraine type 1 (FHM1) is a form of migraine with aura caused by heterozygous mutations in 4 genes: CACNA1A, ATP1A2, SNC1A and PRRT2, but further heterogeneity is expected. Here have been described clinical and molecular features in patients suffering from migraine with Aura (MA), without (MO) and hemiplegic migraine attacks. Next Generation Sequencing by TruSeq Custom Amplicon for CACNA1A and ATP1A2 gene has been performed. All genetic variants have been confirmed by Sanger sequencing and all samples were also analyzed with MLPA assay for ATP1A2-CACNA1A genes to detect duplication or deletion...
August 30, 2018: Journal of Headache and Pain
Chun-Yu Chen, Shih-Pin Chen, Jong-Ling Fuh, Jiing-Feng Lirng, Feng-Chi Chang, Yen-Feng Wang, Shuu-Jiun Wang
BACKGROUND: Limited histopathology studies have suggested that reversible cerebral vasoconstriction syndromes (RCVS) does not present with vascular wall inflammation. Previous vascular imaging studies have had inconsistent vascular wall enhancement findings in RCVS patients. The aim of this study was to determine whether absence of arterial wall pathology on imaging is a universal finding in patients with RCVS. METHODS: We recruited patients with RCVS from Taipei Veterans General Hospital prospectively from 2010 to 2012, with follow-up until 2017 (n = 48)...
August 30, 2018: Journal of Headache and Pain
Delphine Magis, Kevin D'Ostilio, Marco Lisicki, Chany Lee, Jean Schoenen
BACKGROUND: Percutaneous occipital nerve stimulation (ONS) is effective in refractory chronic cluster headache (rCCH) patients. Responders to ONS differ from non-responders by greater glucose metabolism in subgenual anterior cingulate cortex (sgACC). We reasoned that transcranial direct current stimulation (tDCS), a non-invasive approach, might be able to activate this area and thus improve rCCH patients. Our objective was to explore in a pilot trial the therapeutic potential of tDCS (anode at Fz, cathode over C7) and its possible effects on pain perception, frontal executive functions and mood in rCCH patients...
August 20, 2018: Journal of Headache and Pain
Alessandro Viganò, Maria Claudia Torrieri, Massimiliano Toscano, Francesca Puledda, Barbara Petolicchio, Tullia Sasso D'Elia, Angela Verzina, Sonia Ruggiero, Marta Altieri, Edoardo Vicenzini, Jean Schoenen, Vittorio Di Piero
BACKGROUND: Therapeutic management of Chronic Migraine (CM), often associated with Medication Overuse Headache (MOH), is chiefly empirical, as no biomarker predicting or correlating with clinical efficacy is available to address therapeutic choices. The present study searched for neurophysiological correlates of Greater Occipital Nerve Block (GON-B) effects in CM. METHODS: We recruited 17 CM women, of whom 12 with MOH, and 19 healthy volunteers (HV). Patients had no preventive treatment since at least 3 months...
August 20, 2018: Journal of Headache and Pain
Katrine Falkenberg, Jes Olesen
BACKGROUND: Previous studies indicate that sumatriptan is not effective when second messenger levels are high as after cilostazol provocation. Therefore, we have conducted the present study, where sumatriptan is administrated as pretreatment before cAMP increases due to cilostazol intake. Our hypothesis was that pretreatment with sumatriptan would have a significant effect against cilostazol induced headache in healthy volunteers. METHODS: In a double-blind, randomized, crossover design, 30 healthy volunteers of both sexes received cilostazol 200 mg on two separate days, each day preceded by oral sumatriptan (2 × 50 mg) or placebo...
August 17, 2018: Journal of Headache and Pain
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