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Journal of Headache and Pain

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https://www.readbyqxmd.com/read/27924616/the-prevalence-of-primary-headache-disorders-in-ethiopia
#1
Mehila Zebenigus, Redda Tekle-Haimanot, Dawit K Worku, Hallie Thomas, Timothy J Steiner
BACKGROUND: Knowledge of the epidemiology of primary headache disorders in sub-Saharan Africa (SSA) remains very limited. We performed a population-based survey in rural and urban areas of Ethiopia, using methods similar to those of an earlier study in Zambia and tested in multiple other countries by Lifting The Burden. METHODS: In a cross-sectional survey we visited households unannounced in four regions of Ethiopia: the mostly urban populations in Addis Ababa and its environs and rural populations of selected districts in Oromia, Amhara and South Nations Nationalities and People's Regions States (SNNPRS)...
December 2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27921264/validation-of-the-tampa-scale-for-kinesiophobia-for-temporomandibular-disorders-tsk-tmd-in-patients-with-painful-tmd
#2
Songlin He, Jinhua Wang, Ping Ji
BACKGROUND: The aim of the study was to validation of the Tampa Scale for Kinesiophobia for Temporomandibular Disorders (TSK-TMD) for use in patients with painful TMD. METHODS: The original TSK-TMD was translated and cross-culturally adaptated following international guidelines. A total of 160 patients with temporomandibular disorders (TMD) were enrolled to fill out the scale. The internal consistency and test-retest methods were used to evaluate the reliability of the TSK-TMD...
December 2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27905079/the-potential-impact-of-primary-headache-disorders-on-stroke-risk
#3
Chia-Lin Tsai, Chung-Hsing Chou, Pei-Jung Lee, Jiu-Haw Yin, Shao-Yuan Chen, Chun-Chieh Lin, Yueh-Feng Sung, Fu-Chi Yang, Chi-Hsiang Chung, Wu-Chien Chien, Chia-Kuang Tsai, Jiunn-Tay Lee
BACKGROUND: Headache such as migraine is associated with stroke. Studies focused on primary headache disorders (PHDs) as a risk factor for stroke are limited. The purpose of this population-based cohort study was to explore whether patients with PHDs were at a high risk for developing stroke. METHODS: A total of 1346 patients with PHDs were enrolled and compared with 5384 age-, gender- and co-morbidity-matched control cohorts. International Classification of Diseases, Clinical Modification codes were administered for the definition of PHDs, stroke, and stroke risk factors...
December 2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27882516/risk-of-medication-overuse-headache-across-classes-of-treatments-for-acute-migraine
#4
Kristian Thorlund, Christina Sun-Edelstein, Eric Druyts, Steve Kanters, Shanil Ebrahim, Rahul Bhambri, Elodie Ramos, Edward J Mills, Michel Lanteri-Minet, Stewart Tepper
BACKGROUND: The most commonly prescribed medications used to treat migraine acutely are single analgesics, ergots, opioids, and triptans. Due to varying mechanisms of action across drug classes, there is reason to believe that some classes may be less likely than others to elicit Medication Overuse Headache (MOH) than others. We therefore aimed to determine whether certain classes of acute migraine drugs are more likely to elicit MOH than others. METHODS: A comprehensive systematic literature was conducted to identify studies of varying designs that reported on MOH within the considered treatment classes...
December 2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27878523/intravenous-ketamine-for-subacute-treatment-of-refractory-chronic-migraine-a-case-series
#5
Clinton Lauritsen, Santiago Mazuera, Richard B Lipton, Sait Ashina
BACKGROUND: Refractory migraine is a challenging condition with great impact on health related quality of life. Intravenous (IV) ketamine has been previously used to treat various refractory pain conditions. We present a series of patients with refractory migraine treated with intravenous ketamine in the hospital setting. METHODS: Based on retrospective chart review, we identified six patients with refractory migraine admitted from 2010 through 2014 for treatment with intravenous ketamine...
December 2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27844456/cortical-plasticity-between-the-pain-and-pain-free-phases-in-patients-with-episodic-tension-type-headache
#6
Bing Chen, Yuan He, Lei Xia, Li-Li Guo, Jin-Long Zheng
BACKGROUND: State-related brain structural alterations in patients with episodic tension-type headache (ETTH) are unclear. We aimed to conduct a longitudinal study to explore dynamic gray matter (GM) changes between the pain and pain-free phases in ETTH. METHODS: We recruited 40 treatment-naïve ETTH patients and 40 healthy controls. All participants underwent brain structural scans on a 3.0-T MRI system. ETTH patients were scanned in and out of pain phases. Voxel-based morphometry analysis was used to determine the differences in regional gray matter density (GMD) between groups...
December 2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27844455/gbd-2015-migraine-is-the-third-cause-of-disability-in-under-50s
#7
EDITORIAL
Timothy J Steiner, Lars J Stovner, Theo Vos
No abstract text is available yet for this article.
December 2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27812883/chronic-temporomandibular-disorders-disability-pain-intensity-and-fear-of-movement
#8
Alfonso Gil-Martínez, Mónica Grande-Alonso, Ibai López-de-Uralde-Villanueva, Almudena López-López, Josué Fernández-Carnero, Roy La Touche
BACKGROUND: The objective was to compare and correlate disability, pain intensity, the impact of headache on daily life and the fear of movement between subgroups of patients with chronic temporomandibular disorder (TMD). METHODS: A cross-sectional study was conducted in patients diagnosed with chronic painful TMD. Patients were divided into: 1) joint pain (JP); 2) muscle pain (MP); and 3) mixed pain. The following measures were included: Craniomandibular pain and disability (Craniofacial pain and disability inventory), neck disability (Neck Dsiability Index), pain intensity (Visual Analogue Scale), impact of headache (Headache Impact Test 6) and kinesiophobia (Tampa Scale of Kinesiophobia-11)...
December 2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27807767/resting-state-eeg-power-and-coherence-vary-between-migraine-phases
#9
Zehong Cao, Chin-Teng Lin, Chun-Hsiang Chuang, Kuan-Lin Lai, Albert C Yang, Jong-Ling Fuh, Shuu-Jiun Wang
BACKGROUND: Migraine is characterized by a series of phases (inter-ictal, pre-ictal, ictal, and post-ictal). It is of great interest whether resting-state electroencephalography (EEG) is differentiable between these phases. METHODS: We compared resting-state EEG energy intensity and effective connectivity in different migraine phases using EEG power and coherence analyses in patients with migraine without aura as compared with healthy controls (HCs). EEG power and isolated effective coherence of delta (1-3...
December 2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27796733/nonspecific-periaqueductal-gray-lesions-on-t2wi-in-episodic-migraine
#10
Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Shuangfeng Liu, Lin Ma, Shengyuan Yu
BACKGROUND: The specific periaqueductal gray (PAG) lesions with migraine-like headache were easily identified on conventional MR images in clinical practice, and the aim of this study is to investigate the nonspecific periaqueductal gray (PAG) lesions in episodic migraine (EM) patients based on T2 weighted imaging (T2WI). METHODS: T2WI images were obtained from 18 EM patients and 18 normal controls (NC) on 3.0 T MR system. The images were observed by two experienced radiologists, and the lesions were identified on T2WI by consensus by 2 experienced neuroradiologists blinded to the patient identity...
December 2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27778244/thalamo-cortical-network-activity-between-migraine-attacks-insights-from-mri-based-microstructural-and-functional-resting-state-network-correlation-analysis
#11
Gianluca Coppola, Antonio Di Renzo, Emanuele Tinelli, Chiara Lepre, Cherubino Di Lorenzo, Giorgio Di Lorenzo, Marco Scapeccia, Vincenzo Parisi, Mariano Serrao, Claudio Colonnese, Jean Schoenen, Francesco Pierelli
BACKGROUND: Resting state magnetic resonance imaging allows studying functionally interconnected brain networks. Here we were aimed to verify functional connectivity between brain networks at rest and its relationship with thalamic microstructure in migraine without aura (MO) patients between attacks. METHODS: Eighteen patients with untreated MO underwent 3 T MRI scans and were compared to a group of 19 healthy volunteers (HV). We used MRI to collect resting state data among two selected resting state networks, identified using group independent component (IC) analysis...
December 2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27778243/activation-of-the-nuclear-factor-e2-related-factor%C3%A2-2-anitioxidant-response-element-alleviates-the-nitroglycerin-induced-hyperalgesia-in-rats
#12
Wei Di, Xiaolei Shi, Hua Lv, Jun Liu, Hong Zhang, Zhiwei Li, Yannan Fang
BACKGROUND: Antioxidants have been proven to weaken hyperalgesia in neuropathic pain. Endogenous antioxidant defense system may have a role in the prevention of hyperalgesia in migraine. In this study, we aimed to evaluate the role of nuclear factor E2-related factor 2/antioxidant response element (Nrf2/ARE) pathway in regulating the activation of the trigeminovascular system (TGVS) and hypersensitivity in nitroglycerin (NTG)-induced hyperalgesia rats. METHODS: The expression levels of Nrf2, HO, HO1, and NQO1 in the trigeminal nucleus caudalis (TNC) were detected by western blot...
December 2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27771875/increased-default-mode-network-connectivity-and-increased-regional-homogeneity-in-migraineurs-without-aura
#13
Jilei Zhang, Jingjing Su, Mengxing Wang, Ying Zhao, Qian Yao, Qiting Zhang, Haifeng Lu, Hui Zhang, Shuo Wang, Ge-Fei Li, Yi-Lan Wu, Feng-Di Liu, Yan-Hui Shi, Jianqi Li, Jian-Ren Liu, Xiaoxia Du
BACKGROUND: The precuneus/posterior cingulate cortex, which has been associated with pain sensitivity, plays a pivotal role in the default mode network. However, information regarding migraine-related alterations in resting-state brain functional connectivity in the default mode network and in local regional spontaneous neuronal activity is not adequate. METHODS: This study used functional magnetic resonance imaging to acquire resting-state scans in 22 migraineurs without aura and in 22 healthy matched controls...
December 2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27770406/prevalence-of-restless-legs-syndrome-in-migraine-patients-with-and-without-aura-a-cross-sectional-case-controlled-study
#14
Guan-Yu Lin, Yu-Kai Lin, Jiunn-Tay Lee, Meei-Shyuan Lee, Chun-Chieh Lin, Chia-Kuang Tsai, Chi-Hsin Ting, Fu-Chi Yang
BACKGROUND: Although the comorbidity of migraine and restless legs syndrome (RLS) has been well-documented, the association between RLS and migraine frequency has yet to be elucidated. The present study aims to evaluate the prevalence of RLS among individuals who experience low-frequency, high-frequency, or chronic migraine presenting with and without aura. METHODS: We conducted a cross-sectional, case-controlled study involving 505 participants receiving outpatient headache treatment...
December 2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27770405/pharmacology-of-reflex-blinks-in-the-rat-a-novel-model-for-headache-research
#15
M G Jones, A P Andreou, S B McMahon, D Spanswick
BACKGROUND: Migraineurs are highly sensitive to the nitric oxide donor glyceryl trinitrate which triggers attacks in many sufferers. In animal studies, glyceryl trinitrate increases neuronal activity in the trigeminovascular pathway and elevates neurotransmitter levels in the brainstem. Many migraineurs also display alterations in blink reflexes, known to involve brainstem circuits. We investigated the effect of GTN on evoked blinks in the anaesthetised rat to determine whether such reflexes may prove useful as the basis for a novel animal model to evaluate potential anti-migraine therapeutic agents...
December 2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27770404/side-locked-headaches-an-algorithm-based-approach
#16
Sanjay Prakash, Chaturbhuj Rathore
The differential diagnosis of strictly unilateral hemicranial pain includes a large number of primary and secondary headaches and cranial neuropathies. It may arise from both intracranial and extracranial structures such as cranium, neck, vessels, eyes, ears, nose, sinuses, teeth, mouth, and the other facial or cervical structure. Available data suggest that about two-third patients with side-locked headache visiting neurology or headache clinics have primary headaches. Other one-third will have either secondary headaches or neuralgias...
December 2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27770403/characterising-the-premonitory-stage-of-migraine-in-children-a-clinic-based-study-of-100-patients-in-a-specialist-headache-service
#17
N Karsan, P Prabhakar, P J Goadsby
BACKGROUND: The premonitory stage of migraine attacks, when symptomatology outside of pain can manifest hours to days before the onset of the headache, is well recognised. Such symptoms have been reported in adults in a number of studies, and have value in predicting an impending headache. These symptoms have not been extensively studied in children. We aimed to characterise which, if any, of these symptoms are reported in children seen within a Specialist Headache Service. METHODS: We reviewed clinic letters from the initial consultation of children and adolescents seen within the Specialist Headache Service at Great Ormond Street Hospital between 1999 and 2015 with migraine in whom we had prospectively assessed clinical phenotype data...
December 2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27726107/nicotinamide-n-methyltransferase-gene-rs694539-variant-and-migraine-risk
#18
Ali Sazci, Gensay Sazci, Bilgen Sazci, Emel Ergul, Halil Atilla Idrisoglu
BACKGROUND: Migraine is a common neurovascular disorder affecting 10 to 20 % of the world population usually subdivided into migraine with auro (MA) and migraine without auro (MO). Homocysteine is involved in the pathophysiology of a number of neurological disorders. Elevated levels of homocysteine in the plasma is produced by the MTHFR gene rs 1801133 and rs 1801131 variants as well as the NNMT gene rs 694539 variant. METHODS: With the polymerase chain reaction-restriction fragment length polymorphism method developed recently in our laboratory, we were able to show an association between the NNMT gene rs694539 variant and migraine for the first time...
December 2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27709437/insomnia-in-probable-migraine-a-population-based-study
#19
Jiyoung Kim, Soo-Jin Cho, Won-Joo Kim, Kwang Ik Yang, Chang-Ho Yun, Min Kyung Chu
BACKGROUND: Insomnia is a common complaint among individuals with migraine. The close association between insomnia and migraine has been reported in clinic-based and population-based studies. Probable migraine (PM) is a migrainous headache which fulfills all but one criterion in the migraine diagnostic criteria. However, an association between insomnia and PM has rarely been reported. This study is to investigate the association between insomnia and PM in comparison with migraine using data from the Korean Headache-Sleep Study...
December 2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27699586/non-invasive-vagus-nerve-stimulation-nvns-as-mini-prophylaxis-for-menstrual-menstrually-related-migraine-an-open-label-study
#20
Licia Grazzi, Gabriella Egeo, Anne H Calhoun, Candace K McClure, Eric Liebler, Piero Barbanti
BACKGROUND: Menstrual migraine and menstrually related migraine attacks are typically longer, more disabling, and less responsive to medications than non-menstrual attacks. The aim of this study was to evaluate the efficacy, safety, and tolerability of non-invasive vagus nerve stimulation for the prophylactic treatment of menstrual migraine/menstrually related migraine. METHODS: Fifty-six enrolled subjects (menstrual migraine, 9 %; menstrually related migraine, 91 %), 33 (59 %) of whom were receiving other prophylactic therapies, entered a 12-week baseline period...
December 2016: Journal of Headache and Pain
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