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Journal of Headache and Pain

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https://www.readbyqxmd.com/read/29785578/transport-of-the-pituitary-adenylate-cyclase-activating-polypeptide-across-the-blood-brain-barrier-implications-for-migraine
#1
Faisal Mohammad Amin, Henrik Winther Schytz
BACKGROUND: Pituitary adenylate cyclase-activating polypeptide (PACAP) is widely distributed in the nervous system and is involved in migraine pathophysiology. Understanding the function of the blood-brain barrier (BBB) in relation to PACAP is important to the understand the mechanisms behind PACAP-induced migraine attacks, but also to develop antimigraine drugs targeting the PACAP receptors Here, we aim to review the transport ability of PACAP across the BBB. METHODS: We performed a systematic literature search on PubMed to identify studies reporting original data on PACAP and BBB...
May 21, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29777424/use-and-overuse-of-triptans-in-austria-a-survey-based-on-nationwide-healthcare-claims-data
#2
Karin Zebenholzer, Walter Gall, Christian Wöber
BACKGROUND: To evaluate triptan use and overuse as well as prescription patterns in Austria based on a nationwide healthcare database because data on triptan use and overuse in Austria is missing. METHODS: We included all persons insured with one of 19 Austrian social security institutions in 2007. Inclusion criteria comprised an age of 18-99 years, known sex, and receipt of insurance benefits. We defined triptan use as ≥1 package of a triptan dispensed in 2007 and triptan overuse as ≥30 defined daily doses dispensed in at least one quarter...
May 18, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29740710/pituitary-adenylate-cyclase-activating-polypeptide-pacap-another-novel-target-for-treatment-of-primary-headaches
#3
EDITORIAL
Messoud Ashina, Paolo Martelletti
No abstract text is available yet for this article.
May 8, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29671098/answer-to-the-comment-on-castien-et-al-2018-pressure-pain-thresholds-over-the-cranio-cervical-region-in-headache-a-systematic-review-and-meta-analysis
#4
LETTER
René F Castien, Johannes C van der Wouden, Willem De Hertogh
No abstract text is available yet for this article.
April 18, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29671086/the-nrp1-migraine-risk-variant-shows-evidence-of-association-with-menstrual-migraine
#5
Charmaine E Pollock, Heidi G Sutherland, Bridget H Maher, Rodney A Lea, Larisa M Haupt, Alison Frith, E Anne MacGregor, Lyn R Griffiths
BACKGROUND: In 2016, a large meta-analysis brought the number of susceptibility loci for migraine to 38. While sub-type analysis for migraine without aura (MO) and migraine with aura (MA) found some loci showed specificity to MO, the study did not test the loci with respect to other subtypes of migraine. This study aimed to test the hypothesis that single nucleotide polymorphisms (SNPs) robustly associated with migraine are individually or collectively associated with menstrual migraine (MM)...
April 18, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29654441/comment-on-castien-et-al-2018-pressure-pain-thresholds-over-the-cranio-cervical-region-in-headache-a-systematic-review-and-meta-analysis
#6
LETTER
Kerstin Luedtke, Tibor Szikszay, Wacław Adamczyk, Arne May
No abstract text is available yet for this article.
April 13, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29623444/polygenic-risk-score-use-in-migraine-research
#7
Mona Ameri Chalmer, Ann-Louise Esserlind, Jes Olesen, Thomas Folkmann Hansen
BACKGROUND: The latest Genome-Wide Association Study identified 38 genetic variants associated with migraine. In this type of studies the significance level is very difficult to achieve (5 × 10- 8 ) due to multiple testing. Thus, the identified variants only explain a small fraction of the genetic risk. It is expected that hundreds of thousands of variants also confer an increased risk but do not reach significance levels. One way to capture this information is by constructing a Polygenic Risk Score...
April 5, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29619773/discovery-of-pacap-and-its-receptors-in-the-brain
#8
REVIEW
Takahiro Hirabayashi, Tomoya Nakamachi, Seiji Shioda
Pituitary adenylate-cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide (VIP)/glucagon/secretin family. PACAP shows particularly high homology (~ 68%) to VIP. Because of the high homology of the amino acid sequences of PACAP and VIP, these peptides share three class B-G-protein coupled receptors: the PAC1-Receptor (PAC1-R), the VPAC1-Receptor (VPAC1-R) and VPAC2-Receptor (VPAC2-R). These receptors have high homology to each other, and their high homology is utilized for these discoveries...
April 4, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29611008/characteristics-of-menstrual-versus-non-menstrual-migraine-during-pregnancy-a-longitudinal-population-based-study
#9
Beáta Éva Petrovski, Kjersti G Vetvik, Christofer Lundqvist, Malin Eberhard-Gran
BACKGROUND: Migraine is a common headache disorder that affects mostly women. In half of these, migraine is menstrually associated, and ranges from completely asymptomatic to frequent pain throughout pregnancy. METHODS: The aim of the study was to define the pattern (frequency, intensity, analgesics use) of migrainous headaches among women with and without menstural migraine (MM) during pregnancy, and define how hormonally-related factors affect its intensity. RESULTS: The analysis was based upon data from 280 women, 18...
April 2, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29556971/the-epidemiology-of-headache-disorders-a-face-to-face-interview-of-participants-in-hunt4
#10
Knut Hagen, Anders Nikolai Åsberg, Benjamin L Uhlig, Erling Tronvik, Eiliv Brenner, Marit Stjern, Grethe Helde, Gøril Bruvik Gravdahl, Trond Sand
BACKGROUND: The primary aim of this cross-sectional population-based study was to evaluate the 1-year prevalence of common headache disorders by a face-to-face interview. METHODS: The fourth wave of Nord-Trøndelag Health Survey (HUNT4) started in September 2017. The study was undertaken as part of a project mainly focusing on sleep disorders, where a total of 232 (19.3%) out of 1200 invited HUNT4 participants underwent a face-to-face headache interview. RESULTS: The mean age of the 232 participants was 58...
March 20, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29556874/altered-muscle-activity-during-rest-and-during-mental-or-physical-activity-is-not-a-trait-symptom-of-migraine-a-neck-muscle-emg-study
#11
Kerstin Luedtke, Jan Mehnert, Arne May
BACKGROUND: Migraineurs have a high prevalence of neck pain prior to or during headache attacks. Whether neck pain is a symptom of migraine or an indicator for a constant neck muscle dysfunction potentially triggering migraine attacks is a topic of scientific debate. The presence of myofascial trigger points in neck muscles including the trapezius muscle, points towards muscle alterations associated with migraine. We measured electromyography (EMG) of the neck muscles in a large cohort to identify whether neck pain and neckmuscle tension reported by migraine patients can be attributed to increased neck muscle activation during rest, mental stress or physical activity...
March 20, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29541875/gender-differences-in-functional-connectivities-between-insular-subdivisions-and-selective-pain-related-brain-structures
#12
Yu-Jie Dai, Xin Zhang, Yang Yang, Hai-Yan Nan, Ying Yu, Qian Sun, Lin-Feng Yan, Bo Hu, Jin Zhang, Zi-Yu Qiu, Yi Gao, Guang-Bin Cui, Bi-Liang Chen, Wen Wang
BACKGROUND: The incidence of pain disorders in women is higher than in men, making gender differences in pain a research focus. The human insular cortex is an important brain hub structure for pain processing and is divided into several subdivisions, serving different functions in pain perception. Here we aimed to examine the gender differences of the functional connectivities (FCs) between the twelve insular subdivisions and selected pain-related brain structures in healthy adults. METHODS: Twenty-six healthy males and 11 age-matched healthy females were recruited in this cross-sectional study...
March 14, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29536279/pacap-and-migraine-headache-immunomodulation-of-neural-circuits-in-autonomic-ganglia-and-brain-parenchyma
#13
James A Waschek, Serapio M Baca, Simon Akerman
The discovery that intravenous (IV) infusions of the neuropeptide PACAP-38 (pituitary adenylyl cyclase activating peptide-38) induced delayed migraine-like headaches in a large majority of migraine patients has resulted in considerable excitement in headache research. In addition to suggesting potential therapeutic targets for migraine, the finding provides an opportunity to better understand the pathological events from early events (aura) to the headache itself. Although PACAP-38 and the closely related peptide VIP (vasoactive intestinal peptide) are well-known as vasoactive molecules, the dilation of cranial blood vessels per se is no longer felt to underlie migraine headaches...
March 13, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29532195/the-big-cgrp-flood-sources-sinks-and-signalling-sites-in-the-trigeminovascular-system
#14
REVIEW
Karl Messlinger
BACKGROUND: Calcitonin gene-related peptide (CGRP) has long been a focus of migraine research, since it turned out that inhibition of CGRP or CGRP receptors by antagonists or monoclonal IgG antibodies was therapeutic in frequent and chronic migraine. This contribution deals with the questions, from which sites CGRP is released, where it is drained and where it acts to cause its headache proliferating effects in the trigeminovascular system. RESULTS: The available literature suggests that the bulk of CGRP is released from trigeminal afferents both in meningeal tissues and at the first synapse in the spinal trigeminal nucleus...
March 12, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29523978/pacap-and-its-role-in-primary-headaches
#15
REVIEW
Lars Edvinsson, János Tajti, Levente Szalárdy, László Vécsei
Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide implicated in a wide range of functions, such as nociception and in primary headaches. Regarding its localization, PACAP has been observed in the sensory trigeminal ganglion (TG), in the parasympathetic sphenopalatine (SPG) and otic ganglia (OTG), and in the brainstem trigeminocervical complex. Immunohistochemistry has shown PACAP-38 in numerous cell bodies of SPG/OTG, co-stored with vasoactive intestinal peptide (VIP), nitric oxide synthase (NOS) and, to a minor degree, with choline acetyltransferase...
March 9, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29508090/pacap-in-hypothalamic-regulation-of-sleep-and-circadian-rhythm-importance-for-headache
#16
REVIEW
Philip R Holland, Mads Barloese, Jan Fahrenkrug
The interaction between sleep and primary headaches has gained considerable interest due to their strong, bidirectional, clinical relationship. Several primary headaches demonstrate either a circadian/circannual rhythmicity in attack onset or are directly associated with sleep itself. Migraine and cluster headache both show distinct attack patterns and while the underlying mechanisms of this circadian variation in attack onset remain to be fully explored, recent evidence points to clear physiological, anatomical and genetic points of convergence...
March 5, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29500688/protective-effects-of-pacap-in-ischemia
#17
REVIEW
Dora Reglodi, Alexandra Vaczy, Eloísa Rubio-Beltran, Antoinette MaassenVanDenBrink
Pituitary adenylate cyclase activating polypeptide (PACAP) is an ubiquitous peptide involved, among others, in neurodevelopment, neuromodulation, neuroprotection, neurogenic inflammation and nociception. Presence of PACAP and its specific receptor, PAC1, in the trigeminocervical complex, changes of PACAP levels in migraine patients and the migraine-inducing effect of PACAP injection strongly support the involvement of PACAP/PAC1 receptor in migraine pathogenesis. While antagonizing PAC1 receptor is a promising therapeutic target in migraine, the diverse array of PACAP's functions, including protection in ischemic events, requires that the cost-benefit of such an intervention is well investigated by taking all the beneficial effects of PACAP into account...
March 2, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29484508/undifferentiated-headache-broadening-the-approach-to-headache-in-children-and-adolescents-with-supporting-evidence-from-a-nationwide-school-based-cross-sectional-survey-in-turkey
#18
Christian Wöber, Çiçek Wöber-Bingöl, Derya Uluduz, Tuna Stefan Aslan, Uğur Uygunoglu, Ahmet Tüfekçi, Selen Ilhan Alp, Taşkın Duman, Fidan Sürgün, Gülser Karadaban Emir, Caner Feyzi Demir, Ferhat Balgetir, Yeliz Bahar Özdemir, Tanja Auer, Aksel Siva, Timothy J Steiner
BACKGROUND: Headache is a leading disabler in adults worldwide. In children and adolescents, the same may be true but the evidence is much poorer. It is notable that published epidemiological studies of these age groups have largely ignored headaches not fulfilling any specific set of ICHD criteria, although such headaches appear to be common. A new approach to these is needed: here we introduce, and investigate, a diagnostic category termed "undifferentiated headache" (UdH), defined in young people as recurrent mild-intensity headache of < 1 h's duration...
February 27, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29468450/migraine-is-first-cause-of-disability-in-under-50s-will-health-politicians-now-take-notice
#19
EDITORIAL
Timothy J Steiner, Lars J Stovner, Theo Vos, R Jensen, Z Katsarava
No abstract text is available yet for this article.
February 21, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29460121/pacap-and-its-receptors-in-cranial-arteries-and-mast-cells
#20
Inger Jansen-Olesen, Sara Hougaard Pedersen
BACKGROUND: In migraineurs pituitary adenylate cyclase activating peptide1-38 (PACAP1-38) is a potent migraine provoking substance and the accompanying long lasting flushing suggests degranulation of mast cells. Infusion of the closely related vasoactive intestinal peptide (VIP) either induces headache or flushing. This implicates the pituitary adenylate cyclase activating peptide type I receptor (PAC1) to be involved in the pathophysiology of PACAP1-38 provoked headaches. Here we review studies characterizing the effects of mainly PACAP but also of VIP on cerebral and meningeal arteries and mast cells...
February 20, 2018: Journal of Headache and Pain
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