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Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi

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https://www.readbyqxmd.com/read/30568063/expectations-for-the-next-generation-of-simulated-patients-born-from-thoughtful-anticipation-of-artificial-intelligence-equipped-robot
#1
Yoshiaki Hayasaka, Terumichi Fujikura, Masami Kashimura
It is predicted that in the near future robot simulated patients (SPs) will come into use. Through the impressions of five SPs about robot SPs, we explored their vision of the future of medical education as an indicator of what ordinary citizens think. The opinions of SPs were collected using a semi-structured focus group interview, after which the perspectives provided were explored using a qualitative research method called Steps for Coding and Theorization (SCAT). Although SPs accepted the introduction of robot SPs, they regard them as potential substitutes...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/30568062/epidermoid-cyst-arising-on-the-body-of-the-tongue-case-report-and-literature-review
#2
Takashi Ueno, Ryoko Takayama, Shin-Ichi Osada, Hidehisa Saeki
BACKGROUND: Epidermoid cysts of the body of the tongue are rare. Only 12 cases of such lesions have been reported in the English literature. CASE: A 14-year-old boy had a 7×5-mm-sized cystic lesion with a yellowish-white surface on the ventral aspect of his tongue. The cystic wall was composed of squamous epithelium containing keratinous material. No skin appendages were attached to the wall. These findings were consistent with a diagnosis of an epidermoid cyst...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/30568061/the-relationship-between-premature-ventricular-contractions-and-lifestyle-related-habits-among-the-japanese-working-population-fujitsu-cardiovascular-and-respiratory-observational-study-1-fact-1
#3
Hiromitsu Sekizuka, Hitoshi Miyake
BACKGROUND: Premature ventricular contractions (PVCs) are often found in healthy workers at medical checkups. In this study, we aimed to investigate the frequency of PVCs recorded during medical checkups in Japanese office workers without heart disease or other known contributing factors. METHODS: Participants in this study were 17,641 office workers, who underwent an electrocardiogram examination during a regular medical checkup between April 1 2015 and March 31 2016 and had no known heart disease...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/30568060/a-case-with-unique-dermoscopic-findings-collision-of-an-apocrine-gland-cyst-and-a-trichoblastoma
#4
Keigo Ito, Shin-Ichi Ansai, Azusa Ogita, Hidenori Matsuda, Hidehisa Saeki
We report a case of a blue-black nodule on the left upper eyelid of a 77-year-old woman. Dermoscopic examination of the lesion revealed a purple or purple-red homogenous opaque area like that often observed in apocrine gland cysts and a yellow-whitish homogenous structure with arborizing vessels. After resection of the tumor, a final diagnosis of collision of an apocrine gland cyst and a trichoblastoma was made. We should note the possibility that trichoblastoma may exhibit a yellow-whitish homogenous structure in dermoscopy...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/30568059/efficacy-of-mirtazapine-on-irritable-bowel-syndrome-with-anxiety-and-depression-a-case-study
#5
Fumiaki Akama, Katsunaka Mikami, Natsuru Watanabe, Keitaro Kimoto, Kenji Yamamoto, Hideo Matsumoto
Irritable bowel syndrome (IBS) is a disease in which gastrointestinal symptoms-primarily abdominal pain or discomfort and abnormal bowel movements persist chronically. For patients with IBS, mental illness, especially depression and/or anxiety, leads to a further lower quality of life. The purpose of this case study was to investigate the effects of mirtazapine (MIR) on mental health and IBS symptoms in a case of IBS accompanied by anxiety and a depressive state. This case report suggests that MIR is efficacious for the treatment of IBS with predominant diarrhea accompanied by depression and anxiety...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/30568058/the-contribution-of-alcohol-dehydrogenase-3-to-the-development-of-alcoholic-osteoporosis-in-mice
#6
Takahisa Okuda, Munehiro Naruo, Osamu Iijima, Tsutomu Igarashi, Midori Katsuyama, Motoyo Maruyama, Toshio Akimoto, Youkichi Ohno, Takeshi Haseba
BACKGROUND: Alcohol dehydrogenase 3 (ADH3) plays major roles not only in alcohol metabolism but also in nitric oxide metabolism as S-nitrosoglutathione reductase (GSNOR). ADH3/GSNOR regulates both adipogenesis and osteogenesis through the denitrosylation of peroxisome proliferator-activated receptor γ. The current study investigated the contribution of ADH3 to the development of alcoholic osteoporosis in chronic alcohol consumption (CAC). METHODS: Nine-week-old male mice of different ADH genotypes [wild-type (WT) and Adh3-/- ] were administered a 10% ethanol solution for 12 months...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/30568057/diagnostic-value-of-plain-radiography-for-symptomatic-bone-metastasis-at-the-first-visit
#7
Yasuyuki Kitagawa, Takashi Yamaoka, Mari Yokouchi, Toshihiko Ito, Yoshihiro Mizuno, Yoshihiro Sudo, Yong Kim, Ryu Tsunoda, Shinro Takai
BACKGROUND: To prevent and minimize skeletal-related diseases, early diagnosis of bone metastases is important. However, previous reports have shown that plain radiography has low sensitivity and fails to screen multiple asymptomatic lesions. Limited investigations have been reported on the value of plain radiography in the diagnosis of symptomatic bone metastases. Therefore, this study aimed to investigate the diagnostic utility of plain radiography for symptomatic bone metastasis. METHODS: Two experienced orthopedic surgeons retrospectively evaluated the plain radiographs of 39 patients with symptoms during their first visit between 2011 and 2014 for bone metastases...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/30568056/effects-of-endoprosthesis-head-material-on-acetabular-cartilage-metabolism-an-animal-study-using-crossbred-pigs
#8
Shuhei Matsui, Tokifumi Majima, Katsumi Mominoki, Haruko Hirayama, Yasushi Oshima, Kenji Takahashi, Shinro Takai
BACKGROUND: Hip endoprosthesis is one option for the treatment of displaced femoral neck fractures and avascular necrosis of the femoral head. Few reports are available describing acetabular cartilage metabolism after endoprosthesis surgery of the hip. The purpose of this study was to compare the biological effects on cartilage between cobalt-chrome (Co-Cr) and alumina ceramic heads wherein the cartilage articulates directly. METHODS: We used the acetabular cartilage from six hips of three immature crossbred pigs to examine the effects on cytokines, the amount of hyaluronic acid (HA), and cartilage mRNA expression of ceramic head and Co-Cr head endoprosthesis...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/30568055/evaluation-of-resistance-by-clinically-pathogenic-bacteria-to-antimicrobials-and-common-disinfectants-in-beijing-china
#9
Kai Shan, Jianguo Li, Weihai Yao, Jie Li, Xinhua He, Fengjie Li, Wei Wen, Qingyu Liu, Wei Guo
BACKGROUND: Antibiotic resistance of pathogenic bacteria is well recognized among clinicians; however, studies that directly evaluate the bacterial resistance to commonly used disinfectants in clinical settings are lacking. Currently available reports focus on the resistance of single strains to single disinfectants and do not adequately examine the degree of resistance and cross-resistance to antimicrobials in the large-scale clinical use of disinfectants. METHODS: We investigated the resistance capacity to 11 antibiotics and 7 chemical disinfectants by bacterial strains collected from body fluids of patients in 10 hospitals in Beijing, China over a 1-year period...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/30464149/congenital-mesoblastic-nephroma-presenting-with-hematuria-in-a-neonate
#10
Haili Wang, Zhigang Yao, Qingwei Liu
Congenital mesoblastic nephroma (CMN) is a rare tumor of infancy. CMNs can be histologically divided into classic, cellular, and mixed subtypes. Cellular CMNs are difficult to differentiate from Wilms tumors. Herein, a neonate with cellular CMN accompanied by macroscopic hematuria, is described. The clinical, pathological, and imaging features of the disease are discussed.
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/30464148/small-cell-lung-cancer-with-sarcoidosis-in-spontaneous-remission-a-case-report
#11
Yumeka Sasaki, Yasuhiko Koga, Norimitsu Kasahara, Yoshimasa Hachisu, Keisuke Murata, Hiroaki Tsurumaki, Masakiyo Yatomi, Yusuke Tsukagoshi, Yuri Sawada, Reiko Sakurai, Akihiro Ono, Noriaki Sunaga, Kyoichi Kaira, Junko Hirato, Toshitaka Maeno, Kunio Dobashi, Takeshi Hisada
A 69-year-old woman was diagnosed with sarcoidosis, which was not treated with corticosteroid therapy. Her levels of angiotensin converting enzyme decreased significantly over 4 years and a mass lesion was detected near the lower part of her left main bronchus, and diagnosed as small cell lung cancer (SCLC). Treatment of the SCLC with a series of chemotherapeutic agents produced excellent results. The pulmonary sarcoidosis did not show any deterioration despite the frequent use of amrubicin, which is known to be a cause of interstitial pneumonia...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/30464147/valproate-induced-polycystic-ovary-syndrome-in-a-girl-with-epilepsy-a-case-study
#12
Yasuhiko Kawakami, Shuichi Fujii, Gen Ishikawa, Atsuko Sekiguchi, Akihito Nakai, Masato Takase
BACKGROUND: Polycystic ovary syndrome (PCOS) is a common ovulatory disorder that can be induced by sodium valproate (VPA). PATIENT: We report a case of PCOS that developed in a 15-year-old girl with idiopathic epilepsy after she took VPA. VPA administration stopped her seizures, but it also led to weight gain and amenorrhea, and the patient was diagnosed with PCOS on the basis of diagnostic imaging and serological examination results. Cessation of VPA administration led to reduced weight gain and restored menstruation...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/30464146/two-cases-of-sclerotic-fibroma-of-the-skin-that-mimicked-keloids-clinically
#13
Mamiko Tosa, Shin-Ichi Ansai, Hiroaki Kuwahara, Satoshi Akaishi, Rei Ogawa
Sclerotic fibromas of the skin (SFSs) have a very characteristic histology but the clinical signs are non-specific. Consequently, it is extremely difficult to make a diagnosis of SFS on the basis of the clinical findings only. We report here two cases of SFS arising on the right scapular region and the right lower leg, respectively. Both cases were clinically similar to keloids. Skin surgeons should remember that SFSs are an important differential diagnosis from keloids.
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/30464145/two-cases-of-granular-cell-tumors-that-clinically-mimicked-hypertrophic-scars-and-keloids
#14
Mamiko Tosa, Shin-Ichi Ansai, Rei Ogawa
We report two cases of granular cell tumors (GCTs) arising on rare sites, namely, the nape and umbilicus. While GCTs have a very characteristic histology, their clinical signs and symptoms are non-specific. Therefore, it is extremely difficult to make a diagnosis of GCT on the basis of clinical findings only. The two cases reported here were clinically similar to hypertrophic scars and keloids, respectively. Skin surgeons should remember that GCTs are an important differential diagnosis from hypertrophic scars and keloids...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/30464144/challenges-in-the-diagnosis-of-bone-metastasis-in-patients-without-a-history-of-malignancy-at-their-first-clinic-visit
#15
Yasuyuki Kitagawa, Toshihiko Ito, Yoshihiro Mizuno, Yoshihiro Sudo, Yong Kim, Ryu Tsunoda, Masabumi Miyamoto, Shinro Takai
BACKGROUND: Many patients with bone metastases whose diagnoses came only after they had suffered aggravated conditions are still frequently encountered. However, there have been few studies regarding the early diagnosis of such metastases. We retrospectively reviewed the clinical courses of cases we experienced between 2004 and 2014 to clarify the practical situation of diagnosis of such bone metastases. METHODS: We undertook a retrospective review of 56 of our patients with bone metastasis who had no history of malignancy at their first visit, who visited our departments between 2004 and 2014...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/30464143/anti-inflammatory-effects-of-em900-on-cultured-human-nasal-epithelial-cells
#16
Nozomu Wakayama, Shoji Matsune, Eriko Takahara, Kuwon Sekine, Yuma Yoshioka, Mariko Ishida, Satoshi Yamaguchi, Kimihiro Okubo, Toshiaki Sunazuka, Satoshi Ōmura
OBJECTIVES: Macrolide therapy is an important conservative therapy for chronic rhinosinusitis, especially in Japan. The mechanism underlying this therapy involves anti-inflammatory and not antimicrobial activity. However, the administration of long-term low-dose macrolides (LTLMs) causes an increase in the number of antibiotic-resistant bacteria. EM900 is a derivative of erythromycin (EM), with anti-inflammatory but not antibacterial effects. It does not induce macrolide-resistant bacteria as shown by LTLM...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/30464142/correlation-between-pathological-findings-and-the-usefulness-of-clinical-guidelines-for-the-treatment-of-anca-positive-rpgn-a-retrospective-analysis
#17
Takehisa Yamada, Tetsuya Kashiwagi, Akira Shimizu, Shuichi Tsuruoka
BACKGROUND: The physical condition of patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated rapidly progressive glomerulonephritis (RPGN) is at times too critical for physicians to undertake a renal biopsy. In such cases, physicians need to start treatments without determining the pathological features of the disease. However, the prevalent clinical practice guidelines for ANCA-associated RPGN in Japan do not necessitate the pathological findings in a renal biopsy for determining first-line treatments...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/30464141/serum-cytokine-interactions-are-implicated-in-the-mechanism-of-action-of-sublingual-immunotherapy-for-japanese-cedar-pollinosis
#18
Kenichi Shimada, Minoru Gotoh, Kimihiro Okubo, Takachika Hiroi, Osamu Kaminuma, Akihiro Nakaya
OBJECTIVE: This study aimed to investigate whether interactions between multiple serum cytokines may be implicated in the mechanism of action (MOA) of sublingual immunotherapy (SLIT) for Japanese cedar pollinosis. METHODS: A Tokyo Metropolitan Bureau of Social Welfare and Public Health-initiated clinical study of active SLIT involving 202 patients with Japanese cedar pollinosis was jointly conducted by Tokyo Metropolitan Institute of Medical Science and Nippon Medical School between 2006 and 2008...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/30464140/nonsyndromic-congenital-absence-of-the-pectoralis-muscles
#19
Shi-Min Yuan
The congenital absence of the pectoralis muscle is usually a manifestation of Poland syndrome. However, a nonsyndromic congenital absence of this muscle is rare, and such absences are usually partial and unilateral. A complete or bilateral absence is even rarer. Two young men presented to our outpatient clinic with incidentally noted unilateral flat chest walls. By chest computed tomography, they were diagnosed with a congenital unilateral absence of the pectoralis muscles. They did not show any functional disability of the arms...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/30259895/an-8-year-old-girl-with-autoimmune-hepatitis-following-aplastic-anemia
#20
Ayako Nishigori, Tsutomu Hatori, Takeshi Asano
We herein report a case of severe aplastic anemia diagnosed in an 8-year-old girl with a previous diagnosis of autoimmune hepatitis. We found significantly increased CD8+ and CD68+ cell numbers in her bone marrow, which can induce severe organ damage, refractory to immunosuppressive therapy.
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
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