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Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi

Ayako Nishigori, Tsutomu Hatori, Takeshi Asano
We herein report a case of severe aplastic anemia diagnosed in an 8-year-old girl with a previous diagnosis of autoimmune hepatitis. We found significantly increased CD8+ and CD68+ cell numbers in her bone marrow, which can induce severe organ damage, refractory to immunosuppressive therapy.
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
Shotaro Yasuoka, Go Kimura, Yuka Toyama, Keichi Moriya, Keigo Takahashi, Ryo Matsuoka, Keita Shibayama, Kotaro Obayashi, Yasushi Inoue, Takao Shindo, Shigeki Iigaya, Yuki Endo, Jun Akatsuka, Tatsuro Hayashi, Satoko Nakayama, Tsutomu Hamasaki, Koiti Inokuchi, Yukihiro Kondo
A 73-year-old man presented with right lower back pain and dysuria. Right hydronephrosis and a large pelvic large mass were seen on computed tomography (CT). Although his prostate-specific antigen (PSA) was 0.5 ng/mL, an irregularly enlarged, stony, hard prostate was palpable on digital rectal examination. A prostate tumor was suspected, and a transrectal prostate biopsy and right transurethral ureteral stent placement were performed. Histological and immunohistochemical studies revealed diffuse large B-cell lymphoma...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
Kentaro Sonoki, Yuji Tomori, Yoshinori Obara, Mitsuhiko Nanno, Norie Kodera, Shinro Takai
We report a case of trans-scaphoid perilunate fracture-dislocation with concomitant lunotriquetral ligament disruption of the right wrist in a 44-year-old man, sustained from a 10-m fall landing on his outstretched right hand. Open reduction was performed 1 day after injury; at first the palmar dislocation of the lunate was reduced with the palmar approach. Under direct view with the dorsal approach, the scaphoid was comminuted and then treated with open reduction and internal fixation with a double threshold screw using a dorsal approach and a bone graft from the distal radius...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
Yushi Kawasaki, Shinn-Ichi Ansai, Kazuhisa Fujimoto, Hidehisa Saeki, Seiji Kawana
A 52-year-old Japanese woman presented with a 1.5-cm black, glossy, flat, pediculated lump that clinically mimicked a melanocytic nevus on the left temporal side of her head. The subcutaneous tumor beneath the nodule was elastic and hard. A histological examination showed that the tumor was well circumscribed with an exo- and endophytic growth 2.4 × 1.9 cm in size. The lesion contained several keratinous cysts and was composed of funicular fascicles containing squamoid cells. Excessive mucinous material deposition was observed around the tumor periphery and a palisading arrangement of nuclei in the tumor periphery was seen in some areas...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
Junji Ueda, Hiroshi Yoshida, Yasuhiro Mamada, Nobuhiko Taniai, Masato Yoshioka, Atsushi Hirakata, Youichi Kawano, Tetsuya Shimizu, Tomohiro Kanda, Hideyuki Takata, Eiji Uchida
BACKGROUND: Recently, some reports have revealed a relationship between post-hepatectomy prognosis in hepatocellular carcinoma (HCC) and hepatic fibrosis markers. We evaluated the relationship between these markers of hepatic fibrosis, clinicopathological findings, and prognosis. METHODS: Three hundred and sixty patients underwent hepatectomy for HCC in the Nippon Medical School Hospital between 1993 and 2013. We divided these patients into two groups: normal serum hyaluronic acid (HA) levels and abnormal levels...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
Satoshi Yamaguchi, Shoji Matsune, Kuwon Sekine, Nozomu Wakayama, Yasuhiko Kitayama, Yuji Nakamura, Kimihiro Okubo
BACKGROUND: The influence of S-carboxymethylcystein (S-CMC) on the proliferation ability of goblet cells in nasal polyp epithelium in response to inflammatory stimulation was examined. METHODS: The subjects were patients with chronic paranasal sinusitis. An epithelial cell culture system was established using nasal polyp mucosa excised during endoscopic paranasal sinus surgery. The samples were divided into 4 groups (group a: control group, group b: 10 ng/mL tumor necrosis factor-α (TNF-α) treatment group, group c: 10-7 M S-CMC and 10 ng/mL TNF-α treatment group, group d: 10-5 M S-CMC and 10 ng/mL TNF-α treatment group)...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
Masano Sagawa, Kazuhiko Yoshimatsu, Hajime Yokomizo, Yuki Yano, Sachiyo Okayama, Yasufumi Yamada, Takebumi Usui, Kentaro Yamaguchi, Shunichi Shiozawa, Takeshi Shimakawa, Takao Katsube, Hiroyuki Kato, Yoshihiko Naritaka
OBJECTIVE: We evaluated the preoperative patient status including nutrition, immunity, and inflammation as a predictive factor of remote infection (RI) in colorectal cancer surgery. SUBJECTS AND METHODS: A total of 351 patients who underwent colorectal cancer resection were retrospectively analyzed. Factors correlated with RI incidence were identified by logistic analysis and stepwise selection. RESULTS: RI occurred in 27 patients, with an incidence of 7...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
Masato Yanagi, Yasutomo Suzuki, Tsutomu Hamasaki, Kimiyoshi Mizunuma, Masatoku Arai, Hiroyuki Yokota, Satoru Murata, Yukihiro Kondo, Taiji Nishimura
OBJECTIVES: To evaluate the efficacy of early transcatheter arterial embolization for hemodynamically stable patients with The American Association for the Surgery of Trauma (AAST) grade 4 blunt renal trauma. MATERIALS AND METHODS: The medical records of consecutive patients with grade 4 blunt renal trauma who were transported to our two critical care centers in Japan and treated with early transcatheter arterial embolization (TAE) between 2001 and 2013 were retrospectively reviewed...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
Shuji Matsumoto
Balneotherapy is a treatment with healing waters, which includes bathing and physiotherapy in thermal water, therapeutic drinks, medical massage, and water jet massage. It is based on the buoyancy, physical properties, temperature, and chemical effects of mineral water. Throughout European and Japanese medical institutions, balneology and hot spring therapy is very much a part of routine medical treatment. The mechanism of balneotherapy is not yet completely understood. Balneotherapeutic procedures are mainly performed for the prevention, treatment, and rehabilitation of musculoskeletal diseases, but they have also proven useful for various other indications such as for the treatment or rehabilitation of dermatological diseases, immuno-inflammatory diseases, chronic pain syndromes, chronic cardiac diseases, and metabolic syndromes or neurological diseases as well as in the rehabilitation of patients with psychiatric conditions...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
Hong Sang Choi, Yoon Ha Kim, Chang Seong Kim, Seong Kwon Ma, Soo Wan Kim, Eun Hui Bae
We report a case of subclinical central diabetes insipidus (DI), due to Rathke's cleft cysts, that was initially misdiagnosed as transient DI of pregnancy because it presented in the third trimester of pregnancy. A 37-year-old primigravida visited the Department of Obstetrics in the 30th week of gestation due to polyuria. She was admitted due to oligohydramnios; the amniotic fluid index was 3.24. A vasopressin challenge test was performed and her urine osmolality increased by >100% from baseline after the administration of desmopressin...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
Kanae Tsuno, Chiharu Miyatake, Haruna Nishijima, Chiemi Hotta, Tomoko Ogawa, Takeshi Asano
BACKGROUND: Infantile aseptic meningitis is a rare infection of the central nervous system. Coxsackievirus B5 (CVB5) is an enterovirus that is sometimes associated with aseptic meningitis and encephalitis. CASE PRESENTATION: We report on three isolated infants with aseptic meningitis caused by CVB5 in the spring and summer of 2016 with nearly identical 404-bp CVB5 Viral Capsid Protein 1 (VP1) sequences. In addition, viral analysis of sewage samples from Chiba Prefecture in 2016 showed similar 404-bp CVB5 VP1 sequences from May to September 2016...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
Kazuhiko Yoshimatsu, Masano Sagawa, Hajime Yokomizo, Yuki Yano, Sachiyo Okayama, Masaya Satake, Yasufumi Yamada, Atsuo Matsumoto, Shunichi Shiozawa, Takeshi Shimakawa, Takao Katsube, Yoshihiko Naritaka
Incisional surgical site infection (SSI) is a leading complication of stoma reversal procedures. This retrospective study was conducted to assess the incidence of incisional SSI and other wound complications when wound closure was achieved by subcuticular suturing and closed suction drainage following stoma reversal. We analyzed data from a total of 49 patients, all of whom had undergone insertion of a 10 Fr closed suction drainage tube in the fascia, following irrigation with approximately 300 mL of physiological saline...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
Ryuta Nagaoka, Iwao Sugitani, Marie Sanada, Tomoo Jikuzono, Ritsuko Okamura, Takehito Igarashi, Haruki Akasu, Kazuo Shimizu
BACKGROUND: Multiple endocrine neoplasia type 2B (MEN2B) is an extremely rare syndrome mainly caused by RET918 germline mutations. MEN2B typically causes medullary thyroid carcinoma (MTC), pheochromocytoma, and unique physical characteristics including mucosal neuroma, distinctive facial appearance, and Marfanoid habitus. Most patients have abdominal symptoms such as bloating, intermittent constipation, and diarrhea. MTC is the most important determinant of mortality in patients with MEN2B...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
Yushi Kawasaki, Takashi Uehara, Seiji Kawana
Cogan's syndrome (CS) is defined by the combination of hearing loss, vertigo, and ocular inflammation of uncertain cause, and can be associated with variable vessel vasculitis. Vasculitic manifestations may include arteritis (affecting large, medium or small arteries), aortitis, and aortic and mitral valvulitis. Cutaneous manifestations including erythema, papules, subcutaneous nodules, and purpura sometimes occur; however, to date, only six cases have been histologically confirmed to have genuine vasculitis...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
Hiroshi Hashiguchi, Satoshi Iwashita, Kazumasa Abe, Kentaro Sonoki, Minoru Yoneda, Shinro Takai
BACKGROUND: The purpose of this study was to evaluate mid- and long-term clinical and radiologic outcomes of arthroscopic coracoclavicular ligament reconstruction (ACCLR) with an artificial ligament for acute dislocation of the acromioclavicular joint (ACJ). METHODS: Twelve male patients (average age at the time of surgery: 40.8 years, range: 21-64 years) underwent ACCLR with an artificial ligament for acute dislocation of the ACJ type III or type V according to the Rockwood classification...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
Yoshihiko Satake, Kenji Takahashi, Mitsuru Saito, Shinro Takai
BACKGROUND: Aging is a primary risk factor for the development of osteoarthritis (OA). Recently, advanced glycation end products (AGEs) have received much attention in relation to aging and OA. Some AGEs are reported to be brownish, but the association between AGE levels and browning in articular cartilage is unknown. The purposes of this study were first, to develop a colorimetric device to evaluate the quality and aging of the articular cartilage, and second, to investigate the relationship between AGE levels and color of articular cartilage by using this device without enzymatic digestion of the articular surface...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
Takayuki Onohara, Yuichiro Sakamoto, Satoshi Inoue
BACKGROUND: High Mobility Group Box 1 (HMGB-1) is a 30 kDa protein that is a lethal mediator in sepsis and is a recognized therapeutic target. However, no consensus has been reached for acute blood purification therapy as a treatment for sepsis targeting HMGB-1. Previous studies demonstrated that a high anti-HMGB-1 antibody titer and the suppression of HMGB-1 activity improved survival rate in animal sepsis models. The aim of this study was to evaluate whether plasma adsorption therapy is able to decrease the level of HMGB-1, representing a new potential treatment strategy against sepsis...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
Yasuhiro Takenaka, Ikuo Inoue, Takanari Nakano, Masaaki Ikeda, Yoshihiko Kakinuma, Yuichi Ikegami, Akira Shimada, Mitsuhiko Noda
BACKGROUND: The antidiabetic drug teneligliptin is a novel dipeptidyl peptidase-4 (DPP-4) inhibitor with a thiazolidine-specific structure. This study aimed to investigate whether teneligliptin can activate PPARγ directly and/or indirectly in cell-based assays. METHODS: Promoter assays using the reporter construct driven under the control of the SV40 promoter and the PPAR response element (PPRE) were performed. Luciferase activity was measured after a 3-day incubation of vector-transduced cells with various concentrations of teneligliptin...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
Yoshinori Kobayashi
Idiopathic ventricular premature contractions (VPCs), defined as VPCs in the absence of obvious structural heart disease, are one of the common types of arrhythmia in clinical practice. They are sometimes complicated with non-sustained ventricular tachycardia (VT), and/or sustained VT with almost same QRS morphology in 12 leads ECG. Idiopathic VT (IVT) commonly occurs by focal mechanisms and the origins are distributed in a variety of sites in both ventricles. In this article, the clinical characteristics of IVT/IVPCs, the diagnostic algorithm, and how to ablate them will be reviewed...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
Shijie Mo, Zexuan Su, Baoli Heng, Weijun Chen, Liping Shi, Xinghua Du, Caiyong Lai
BACKGROUND/AIM: Epigenetic inactivation of tumor suppressor genes is an important molecular mechanism in the formation and development of human tumors. The purpose of our study was to evaluate the correlation between the methylation level of the secreted frizzled-related protein 1 (SFRP1) gene and the risk of renal cell carcinoma (RCC). METHODS: The relevant literature was searched in detail in several electronic databases. The methodological heterogeneity was analyzed by meta-regression and subgroup analyses...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
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