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Israel Medical Association Journal: IMAJ

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https://www.readbyqxmd.com/read/28853536/impact-of-uveitis-on-quality-of-life-a-prospective-study-from-a-tertiary-referral-rheumatology-ophthalmology-collaborative-uveitis-center-in-italy
#1
Claudia Fabiani, Antonio Vitale, Ida Orlando, Marco Capozzoli, Fiorella Fusco, Francesco Rana, Rossella Franceschini, Jurgen Sota, Bruno Frediani, Mauro Galeazzi, Gian Marco Tosi, Luca Cantarini
BACKGROUND: Non-infectious uveitis (NIU) leads to severe visual impairment, potentially impacting on health-related quality of life (QoL). OBJECTIVES: To investigate the impact of NIU on QoL. METHODS: Eighty NIU patients and 23 healthy controls completed the 36-item Short-Form Health Survey (SF)-36. The SF-36 values were statistically analyzed to evaluate differences between patients and healthy controls and to identify correlations between SF-36 subscores and clinical/demographic data...
August 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28825775/image-challenge-mysterious-ulcers
#2
Amir Dagan, Chen Avaky, Michael Ehrenfeld, Gad Segal
No abstract text is available yet for this article.
August 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28825774/expecting-the-unexpected-a-case-of-e-coli-endocarditis-necessitating-extraction-of-an-implanted-cardioverter-defibrillator-system
#3
Liron Hofstetter, Sagit Ben Zekry, Naama Pelz-Sinvani, Michael Kogan, Vladislav Litachevsky, Avi Sabbag, Gad Segal
No abstract text is available yet for this article.
August 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28825773/the-challenge-of-ovarian-cancer-steps-toward-early-detection-through-advanced-signal-processing-in-magnetic-resonance-spectroscopy
#4
REVIEW
Karen Belkić, Dževad Belkić
Ovarian cancer is a major cause of cancer death among women worldwide, and particularly in Israel. Although the disease at stage IA has 5 year survival rates of over 90%, early detection methods are not sufficiently accurate. Consequently, ovarian cancer is typically diagnosed late, which results in high fatality rates. An excellent candidate for early ovarian cancer detection would be in vivo magnetic resonance spectroscopy (MRS) because it is non-invasive and free of ionizing radiation. In addition, it potentially identifies metabolic features of cancer...
August 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28825772/biomarkers-in-rheumatoid-arthritis
#5
REVIEW
Fabiola Atzeni, Rossella Talotta, Ignazio F Masala, Sara Bongiovanni, Laura Boccassini, Piercarlo Sarzi-Puttini
Biomarkers are important for guiding the clinical and therapeutic management of all phases of rheumatoid arthritis because they can help to predict disease development in subjects at risk, improve diagnosis by closing the serological gap, provide prognostic information that is useful for making therapeutic choices and assessing treatment responses and outcomes, and allow disease activity and progression to be monitored. Various biomarkers can be used to identify subjects susceptible to the disease and those with pre-clinical rheumatoid arthritis before the onset of symptoms such as rheumatoid factor and anti-citrullinated protein antibodies...
August 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28825771/vitamin-d-and-the-immune-system
#6
EDITORIAL
Shir Azrielant, Yehuda Shoenfeld
No abstract text is available yet for this article.
August 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28825770/from-old-to-new-cardiovascular-complications-in-ankylosing-spondylitis
#7
EDITORIAL
Fabiola Atzeni, Marco Corda, Piercarlo Sarzi-Puttini, Francesco Caso, Maurizio Turiel
No abstract text is available yet for this article.
August 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28825769/vitamin-d-cathelicidin-prolactin-autoantibodies-and-cytokines-in-different-forms-of-pulmonary-tuberculosis-versus-sarcoidosis
#8
Irina Vasilyevna Belyaeva, Leonid Pavlovitch Churilov, Liya Robertovnа Mikhailova, Aleksey Vladimirovitch Nikolaev, Anna Andreevna Starshinova, Piotr Kazimirovitch Yablonsky
BACKGROUND: Vitamin D insufficiency is associated with autoimmune and chronic inflammatory diseases such as tuberculosis and sarcoidosis. OBJECTIVES: To evaluate the vitamin D-dependent mechanisms of immunity and autoimmunity in different forms of pulmonary tuberculosis and sarcoidosis. METHODS: We measured the serum levels of 25(OH)D and 1,25(OH)2D, individual autoimmune profiles, plasma concentrations of cathelicidin, several hormones, and production of nine cytokines in patients with short- and long-duration tuberculosis and sarcoidosis...
August 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28825768/factors-associated-with-compliance-of-folic-acid-consumption-among-pregnant-women
#9
Yael Yagur, Saja Anaboussi, Mordechai Hallak, Alon Shrim
BACKGROUND: The prevalence of major malformations in the general population is estimated at 5% of all live births. Prenatal diagnosis is an important scientific tool that allows reliable consultation and improves pregnancy outcome. In 2008, congenital malformations were the leading cause of death in Muslim infants and the second cause of death in Jewish infants in Israel. It is known that folic acid consumption prior to pregnancy decreases the rate of several fetal malformations. OBJECTIVES: To assess the folic acid consumption rate and to characterize variables associated with its use among pregnant women attending a rural medical center...
August 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28825767/clinical-and-parental-status-of-patients-with-congenital-heart-disease-associated-pulmonary-arterial-hypertension
#10
Amiram Nir, Neville Berkman, Sagui Gavri
BACKGROUND: Pulmonary arterial hypertension (PAH) is a significant consequence of congenital heart disease (CHD). Its presence and severity is associated with increased morbidity and mortality. OBJECTIVES: To evaluate the clinical and demographic characteristics of adults with congenital heart diseases (ADCHD) and PAH at a single center. METHODS: A prospective registry of all patients with PAH was conducted between 2009 and 2015. RESULTS: Thirty-two patients were identified...
August 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28825766/trends-in-continuity-of-pregnancy-in-women-with-positive-cytomegalovirus-igm-during-the-first-trimester-2008-2009
#11
Ron Beloosesky, Ilana Feldblum, Alon Shrim, Jenny Kertes, Jacob Segal, Rachel Bachar, Yefet Youval
BACKGROUND: Cytomegalovirus (CMV) infection during pregnancy is the most common cause of intrauterine infection, and is a common cause of sensorineural hearing loss and mental retardation. OBJECTIVES: To evaluate trends in amniocentesis and pregnancy outcome in women with suspected cytomegalovirus (CMV) infection during the first trimester. METHODS: All blood tests for CMV immunoglobulin M (IgM) done between 2008 and 2009 on pregnant women who were enrolled in the Maccabi Healthcare Services were retrieved from laboratory database...
August 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28825765/impact-of-uveitis-on-quality-of-life-a-prospective-study-from-a-tertiary-referral-rheumatology-ophthalmology-collaborative-uveitis-center-in-italy
#12
Claudia Fabiani, Antonio Vitale, Ida Orlando, Marco Capozzoli, Fiorella Fusco, Francesco Rana, Rossella Franceschini, Jurgen Sota, Bruno Frediani, Mauro Galeazzi, Gian Marco Tosi, Luca Cantarini
BACKGROUND: Non-infectious uveitis (NIU) leads to severe visual impairment, potentially impacting on health-related quality of life (QoL). OBJECTIVES: To investigate the impact of NIU on QoL. METHODS: Eighty NIU patients and 23 healthy controls completed the 36-item Short-Form Health Survey (SF)-36. The SF-36 values were statistically analyzed to evaluate differences between patients and healthy controls and to identify correlations between SF-36 subscores and clinical/demographic data...
August 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28825764/systemic-sclerosis-exploring-the-potential-interplay-between-thyroid-disorders-and-pregnancy-outcome-in-an-italian-cohort
#13
Paola Triggianese, Paola Conigliaro, Maria Sole Chimenti, Carmen Barbato, Elisabetta Greco, Barbara Kroegler, Caterina De Carolis, Roberto Perricone
BACKGROUND: Evidence has shown that pregnancy failure (PF) in women with systemic sclerosis (SSc) consists mainly of preterm delivery (PD) and intrauterine growth restriction (IUGR). Thyroid dysfunction (TD) and Hashimoto's thyroiditis (HT) represent a common feature of SSc. Since TD has been associated with PF, its presence in SSc women may potentially affect pregnancy outcome. OBJECTIVES: To analyze the interplay between TD and PF in a cohort of SSc women. METHODS: SSc women (n=77) and age-matched controls from the general obstetric population (n=50) were included...
August 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28825763/factors-predicting-2-years-of-remission-and-low-disease-activity-in-rheumatoid-arthritis-patients-treated-with-tnf-inhibitors
#14
Paola Conigliaro, Paola Triggianese, Maria Sole Chimenti, Marco Tonelli, Flavia Sunzini, Barbara Kroegler, Roberto Perricone
BACKGROUND: The goals of treatment for rheumatoid arthritis (RA) are remission and low disease activity (LDA). However, many patients do not reach or maintain these targets with regard to disease control. OBJECTIVES: To identify predictive factors of remission/LDA in a cohort of RA patients who started treatment with first line tumor necrosis factor-inhibitors (TNF-i). METHODS: We included 308 RA patients treated with first line TNF-i for 2 years to evaluate remission/LDA based on the 28-joint disease activity score (DAS28)...
August 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28871669/facilitated-subcutaneous-immunoglobulin-fscig-in-autoimmune-cytopenias-associated-with-common-variable-immunodeficiency
#15
Veronica Pedini, Isabella Savore, Giovanna Maria Danieli
BACKGROUND: Common variable immunodeficiency (CVID) is the most common symptomatic primary immune deficiency of adulthood. Besides recurrent infections, autoimmune disorders-mainly cytopenias-affect 30% of patients with CVID. OBJECTIVES: To describe the efficacy and safety of facilitated subcutaneous immunoglobulin (fSCIg), which is a combination of 10% [human] SCIg with recombinant human hyaluronidase for the treatment of CVID-linked cytopenias. METHODS: We describe four women (mean age 54 years) with CVID associated with idiopathic thrombocytopenic purpura (ITP) (n=3) and autoimmune hemolytic anemia (AIHA) (n=1)...
July 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28853535/intravitreal-dexamethasone-implant-as-an-adjunct-weapon-for-severe-and-refractory-uveitis-in-beh%C3%A3-et-s-disease
#16
Claudia Fabiani, Giacomo Emmi, Giuseppe Lopalco, Lorenzo Vannozzi, Daniela Bacherini, Silvana Guerriero, Rossella Franceschini, Bruno Frediani, Florenzo Iannone, Gian Marco Tosi, Donato Rigante, Luca Cantarini
BACKGROUND: The evidence on the use of dexamethasone implants in the treatment of Behçet's disease (BD)-related uveitis is limited to a few cases. OBJECTIVES: To evaluate the efficacy of dexamethasone implants on ocular functional, morphological, and clinical parameters in BD patients with severe refractory uveitis. METHODS: Five eyes from five BD patients were enrolled. A single intravitreal dexamethasone injection was applied to each eye...
July 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28796467/anti-glomerular-basement-membrane-antibody-diagnostics-in-a-large-cohort-tertiary-center-should-we-trust-serological-findings
#17
Abdulla Watad, Nicola Luigi Bragazzi, Kassem Sharif, Ora Shovman, Boris Gilburd, Howard Amital, Yehuda Shoenfeld
BACKGROUND: Anti-glomerular basement membrane (GBM) antibody disease, or Goodpasture's disease, is the clinical manifestation of the production of anti-GBM antibodies, which causes rapidly progressive glomerulonephritis with or without pulmonary hemorrhage. Anti-GBM antibody detection is mandatory for the diagnosis of Goodpasture's disease either from the serum or kidney biopsy. Renal biopsy is necessary for disease confirmation; however, in cases in which renal biopsy is not possible or is delayed, serum detection of anti-GBM antibody is the only way for diagnosis...
July 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28796466/adjuvants-and-autoimmunity-why-do-we-develop-autoantibodies-autoimmune-diseases-and-lymphomas
#18
EDITORIAL
Nicola Luigi Bragazzi, Abdulla Watad, Mohammad Adawi, Howard Amital, Gali Aljadeff, Yehuda Shoenfeld
No abstract text is available yet for this article.
July 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28786265/pseudoseptic-arthritis-with-low-synovial-fluid-glucose-in-familial-mediterranean-fever
#19
Abid Awisat, Gleb Slobodin, Nizar Jiries, Michael Rozenbaum, Doron Rimar, Nina Boulman, Lisa Kaly, Karina Zilber, Shira Ginsberg, Itzhak Rosner
No abstract text is available yet for this article.
July 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28786264/morphea-sculpted-in-silica-a-case-report-of-limited-cutaneous-systemic-sclerosis-in-a-woman-with-long-time-exposure-to-silica-dust
#20
João Pedro Gomes, Yehuda Shoenfeld
No abstract text is available yet for this article.
July 2017: Israel Medical Association Journal: IMAJ
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