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Israel Medical Association Journal: IMAJ

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https://www.readbyqxmd.com/read/28796467/anti-glomerular-basement-membrane-antibody-diagnostics-in-a-large-cohort-tertiary-center-should-we-trust-serological-findings
#1
Abdulla Watad, Nicola Luigi Bragazzi, Kassem Sharif, Ora Shovman, Boris Gilburd, Howard Amital, Yehuda Shoenfeld
BACKGROUND: Anti-glomerular basement membrane (GBM) antibody disease, or Goodpasture's disease, is the clinical manifestation of the production of anti-GBM antibodies, which causes rapidly progressive glomerulonephritis with or without pulmonary hemorrhage. Anti-GBM antibody detection is mandatory for the diagnosis of Goodpasture's disease either from the serum or kidney biopsy. Renal biopsy is necessary for disease confirmation; however, in cases in which renal biopsy is not possible or is delayed, serum detection of anti-GBM antibody is the only way for diagnosis...
July 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28796466/adjuvants-and-autoimmunity-why-do-we-develop-autoantibodies-autoimmune-diseases-and-lymphomas
#2
EDITORIAL
Nicola Luigi Bragazzi, Abdulla Watad, Mohammad Adawi, Howard Amital, Gali Aljadeff, Yehuda Shoenfeld
No abstract text is available yet for this article.
July 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28786265/pseudoseptic-arthritis-with-low-synovial-fluid-glucose-in-familial-mediterranean-fever
#3
Abid Awisat, Gleb Slobodin, Nizar Jiries, Michael Rozenbaum, Doron Rimar, Nina Boulman, Lisa Kaly, Karina Zilber, Shira Ginsberg, Itzhak Rosner
No abstract text is available yet for this article.
July 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28786264/morphea-sculpted-in-silica-a-case-report-of-limited-cutaneous-systemic-sclerosis-in-a-woman-with-long-time-exposure-to-silica-dust
#4
João Pedro Gomes, Yehuda Shoenfeld
No abstract text is available yet for this article.
July 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28786263/the-management-of-systemic-lupus-erythematosus-sle-patients-in-remission
#5
REVIEW
Margherita Zen, Mariele Gatto, Linda Nalotto, Maddalena Larosa, Luca Iaccarino, Andrea Doria
No abstract text is available yet for this article.
July 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28786262/adult-primary-central-nervous-system-vasculitis
#6
REVIEW
Carlo Salvarani, Robert D Brown, Gene G Hunder
No abstract text is available yet for this article.
July 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28786261/evolving-frontiers-in-the-treatment-of-periodic-fever-aphthous-stomatitis-pharyngitis-cervical-adenitis-pfapa-syndrome
#7
REVIEW
Donato Rigante, Stefano Gentileschi, Antonio Vitale, Giusyda Tarantino, Luca Cantarini
Fevers recurring at a nearly predictable rate every 3-8 weeks are the signature symptom of periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) syndrome, an acquired autoinflammatory disorder which recurs in association with at least one sign among aphthous stomatitis, pharyngitis, and/or cervical lymph node enlargement without clinical signs related to upper respiratory airways or other localized infections. The disease usually has a rather benign course, although it might relapse during adulthood after a spontaneous or treatment-induced resolution in childhood...
July 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28786260/vitamin-d-and-autoimmune-diseases-is-vitamin-d-receptor-vdr-polymorphism-the-culprit
#8
REVIEW
Giorgia Bizzaro, Antonio Antico, Antonio Fortunato, Nicola Bizzaro
Vitamin D deficiency is becoming an increasing problem worldwide. It should not be underestimated, not only due to the well-known consequences vitamin D deficiency has on bone health, but primarily because recent studies have shown how the biologically active form of vitamin D - 1,25(OH)2D - is involved in many biological processes, including immune system modulation. Moreover, the presence of a vitamin D receptor was discovered in almost all immune cells and some of its polymorphisms were found to be associated with increased incidence of autoimmune diseases...
July 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28786259/adenosine-deaminase-2-deficiency-more-than-monogenic-vasculitis
#9
REVIEW
Yackov Berkun, Reeval Segel, Paulina Navon-Elkan
No abstract text is available yet for this article.
July 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28786258/the-role-of-hyperbaric-oxygen-therapy-in-orthopedics-and-rheumatological-diseases
#10
REVIEW
Giuseppe Barilaro, Ignazio Francesco Masala, Renato Parracchini, Cesare Iesu, Giulia Caddia, Piercarlo Sarzi-Puttini, Fabiola Atzeni
Hyperbaric oxygen therapy (HBOT) has been investigated as a primary/adjunctive treatment for a number of injuries and medical conditions including traumatic ischemia, necrotizing soft tissue injuries, non-healing ulcers and osteoradionecrosis, but the results are controversial. There is insufficient evidence to support or reject the use of HBOT to quicken healing or to treat the established non-union of fractures. However, in patients with fibromyalgia, HBOT reduces brain activity in the posterior cortex and increases it in the frontal, cingulate, medial temporal and cerebellar cortices, thus leading to beneficial changes in brain areas that are known to function abnormally...
July 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28786257/anti-glomerular-basement-membrane-antibody-diagnostics-in-a-large-cohort-tertiary-center-should-we-trust-serological-findings
#11
Abdulla Watad, Nicola Luigi Bragazzi, Kassem Sharif, Ora Shovman, Boris Gilburd, Howard Amital, Yehuda Shoenfeld
BACKGROUND: Anti-glomerular basement membrane (GBM) antibody disease, or Goodpasture's disease, is the clinical manifestation of the production of anti-GBM antibodies, which causes rapidly progressive glomerulonephritis with or without pulmonary hemorrhage. Anti-GBM antibody detection is mandatory for the diagnosis of Goodpasture's disease either from the serum or kidney biopsy. Renal biopsy is necessary for disease confirmation; however, in cases in which renal biopsy is not possible or is delayed, serum detection of anti-GBM antibody is the only way for diagnosis...
July 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28786256/facilitated-subcutaneous-immunoglobulin-fscig-in-autoimmune-cytopenias-associated-with-common-variable-immunodeficiency
#12
Veronica Pedini, Isabella Savore, Maria Giovanna Danieli
BACKGROUND: Common variable immunodeficiency (CVID) is the most common symptomatic primary immune deficiency of adulthood. Besides recurrent infections, autoimmune disorders-mainly cytopenias-affect 30% of patients with CVID. OBJECTIVES: To describe the efficacy and safety of facilitated subcutaneous immunoglobulin (fSCIg), which is a combination of 10% [human] SCIg with recombinant human hyaluronidase for the treatment of CVID-linked cytopenias. METHODS: We describe four women (mean age 54 years) with CVID associated with idiopathic thrombocytopenic purpura (ITP) (n=3) and autoimmune hemolytic anemia (AIHA) (n=1)...
July 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28786255/intravitreal-dexamethasone-implant-as-an-adjunct-weapon-for-severe-and-refractory-uveitis-in-beh%C3%A3-et-s-disease
#13
Claudia Fabiani, Giacomo Emmi, Giuseppe Lopalco, Lorenzo Vannozzi, Daniela Bacherini, Silvana Guerriero, Rossella Franceschini, Bruno Frediani, Florenzo Iannone, Gian Marco Tosi, Donato Rigante, Luca Cantarini
BACKGROUND: The evidence on the use of dexamethasone implants in the treatment of Behçet's disease (BD)-related uveitis is limited to a few cases. OBJECTIVES: To evaluate the efficacy of dexamethasone implants on ocular functional, morphological, and clinical parameters in BD patients with severe refractory uveitis. METHODS: Five eyes from five BD patients were enrolled. A single intravitreal dexamethasone injection was applied to each eye...
July 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28786254/the-association-between-giant-cell-arteritis-and-ischemic-heart-disease-a-population-based-cross-sectional-study
#14
Amir Dagan, Naim Mahroum, Gad Segal, Shmuel Tiosano, Abdulla Watad, Doron Comaneshter, Arnon D Cohen, Howard Amital
BACKGROUND: Patients with giant cell arteritis (GCA) suffer from inflammatory diseases often treated by large amounts of corticosteroids. Whether this inflammatory burden also carries an increased risk for cardiovascular morbidity, and especially ischemic heart disease, is not clearly established. OBJECTIVES: To clarify the linkage between GCA and ischemic heart disease. METHODS: In a cross-sectional study, we assessed the association between GCA and ischemic heart disease, adjusting for cardiovascular risk factors, among GCA patients and matched controls using the database of the largest healthcare provider in Israel...
July 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28786253/effects-of-abatacept-on-t-lymphocyte-sub-populations-and-immunoglobulins-in-patients-affected-by-rheumatoid-arthritis
#15
Paola Conigliaro, Paola Triggianese, Emiliano Giampà, Maria Sole Chimenti, Barbara Kroegler, Roberto Perricone
BACKGROUND: Abatacept acts as a co-stimulation modulator preventing activation of T cells. Although it is approved for the treatment of rheumatoid arthritis (RA), its effects on adaptive immune response have not been fully elucidated. OBJECTIVES: To observe, in a cohort study, based on a clinical practice setting, the variation of peripheral blood T cells, immunoglobulin levels, and autoantibodies in the serum of RA patients during abatacept therapy. METHODS: Our study comprised 48 RA patients treated with abatacept...
July 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28786252/adjuvants-and-autoimmunity-why-do-we-develop-autoantibodies-autoimmune-diseases-and-lymphomas
#16
EDITORIAL
Nicola Luigi Bragazzi, Abdulla Watad, Mohammad Adawi, Howard Amital, Gali Aljadeff, Yehuda Shoenfeld
No abstract text is available yet for this article.
July 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28786251/the-5th-israel-italy-meeting-advances-in-rheumatology-and-autoimmunity
#17
EDITORIAL
Elias Toubi
No abstract text is available yet for this article.
July 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28796465/lungs-in-white-induced-by-docetaxel
#18
Abdulla Watad, Nicola Luigi Bragazzi, Noam Grysman, Hussein Mahagna, Howard Amital
Taxanes are often used in the treatment of many types of cancers. Side effects of docetaxel are not as well documented as paclitaxel, but both can cause pulmonary injury. We present a dramatic case of a patient being treated for prostatic adenocarcinoma with docetaxel who presented with interstitial pneumonitis and responded dramatically to the early treatment with corticosteroids. This case is important as it reveals the side effects of docetaxel administration without administration of other chemotherapeutic agents, and it illustrates the importance of early diagnosis and treatment of docetaxel-induced interstitial pneumonitis...
June 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28796464/the-impact-of-fasting-on-rheumatic-diseases
#19
EDITORIAL
Nicola Luigi Bragazzi, Abdulla Watad
No abstract text is available yet for this article.
June 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28661115/lungs-in-white-induced-by-docetaxel
#20
Abdulla Watad, Nicola Luigi Bragazzi, Noam Grysman, Hussein Mahagna, Howard Amital
Taxanes are often used in the treatment of many types of cancers. Side effects of docetaxel are not as well documented as paclitaxel, but both can cause pulmonary injury. We present a dramatic case of a patient being treated for prostatic adenocarcinoma with docetaxel who presented with interstitial pneumonitis and responded dramatically to the early treatment with corticosteroids. This case is important as it reveals the side effects of docetaxel administration without administration of other chemotherapeutic agents, and it illustrates the importance of early diagnosis and treatment of docetaxel-induced interstitial pneumonitis...
June 2017: Israel Medical Association Journal: IMAJ
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