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Biogerontology

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https://www.readbyqxmd.com/read/28331994/daily-socs1-rhythms-alter-with-aging-differentially-in-peripheral-clocks-in-male-wistar-rats-therapeutic-effects-of-melatonin
#1
Ch Vinod, Anita Jagota
Suprachiasmatic nucleus (SCN) in synchronization with the peripheral clocks regulates the temporal oscillations leading to overt rhythms. Aging leads to attenuation of such circadian regulation, accompanied by increased inflammatory mediators prevalently the cytokines. Suppressors of cytokine signaling (SOCS) family of proteins such as SOCS 1, 3 and cytokine-inducible SH2-containing protein (CIS) negatively regulate the cytokine signaling pathway. The role of SOCS1 in aging and circadian system is obscure. We therefore studied the daily rhythms of rSocs1 mRNA expression at Zeitgeber time (ZT) -0, 6, 12 and 18 in peripheral clocks such as liver, kidney, intestine and heart of 3, 12 and 24 months (m) old male Wistar rats...
March 22, 2017: Biogerontology
https://www.readbyqxmd.com/read/28316012/associations-of-visceral-fat-area-and-physical-activity-levels-with-the-risk-of-metabolic-syndrome-in-postmenopausal-women
#2
Izabela Zając-Gawlak, Barbara Kłapcińska, Aleksandra Kroemeke, Dariusz Pośpiech, Jana Pelclová, Miroslava Přidalová
This study was aimed at the evaluation of relationship between visceral fat area (VFA) and physical activity (PA) with the metabolic syndrome (MetS) risk in the physically active postmenopausal women. A total of 85 attendants of the University of the Third Age (U3A) aged 62.8 ± 5.9 years (median time since menopause 11.8 y), participated in this study. VFA was assessed by bioimpedance method using InBody 720 analyzer. PA was assessed using the ActiGraph GT1 M accelerometer. Fasting levels of serum lipids (TG, HDL), serum glucose, waist circumference (WC) and blood pressure were measured to diagnose MetS according to NCEP-ATP III criteria...
March 18, 2017: Biogerontology
https://www.readbyqxmd.com/read/28316011/changes-in-pro-inflammatory-markers-and-leucine-concentrations-in-response-to-nordic-walking-training-combined-with-vitamin-d-supplementation-in-elderly-women
#3
A Gmiat, J Mieszkowski, K Prusik, K Prusik, J Kortas, A Kochanowicz, A Radulska, M Lipiński, M Tomczyk, J Jaworska, J Antosiewicz, E Ziemann
Mechanisms underpinning age-related decreases in muscle strength and muscle mass relate to chronic inflammation. Physical activity induces an anti-inflammatory effect, but it is modulated by additional factors. We hypothesized that vitamin D, which has also anti-inflammatory activity will modify adaptation to exercise and reduce inflammation in elderly women. Twenty-seven women aged 67 ± 8 years were included and divided into groups with baseline vitamin D concentration more than 20 ng mL(-1) (MVD) and less than 20 ng mL(-1) (LVD)...
March 18, 2017: Biogerontology
https://www.readbyqxmd.com/read/28314935/a-disease-with-a-sweet-tooth-exploring-the-warburg-effect-in-alzheimer-s-disease
#4
REVIEW
Anna Atlante, Lidia de Bari, Antonella Bobba, Giuseppina Amadoro
After more than 80 years from the revolutionary discoveries of Otto Warburg, who observed high glucose dependency, with increased glycolysis and lactate production regardless of oxygen availability in most cancer cells, the 'Warburg effect' returns to the fore in neuronal cells affected by Alzheimer's disease (AD). Indeed, it seems that, in the mild phase of AD, neuronal cells "prefer" to use the energetically inefficient method of burning glucose by glycolysis, as in cancer, proving to become resistant to β-amyloid (Aβ)-dependent apoptosis...
March 17, 2017: Biogerontology
https://www.readbyqxmd.com/read/28281015/pleiotropic-effects-of-ucp2-ucp3-variability-on-leucocyte-telomere-length-and-glucose-homeostasis
#5
Serena Dato, Francesco De Rango, Paolina Crocco, Giuseppe Passarino, Giuseppina Rose
The rate of telomere-shortening has been widely reported as a marker of risk for age-related conditions and mortality in human population. Genetic, environmental and stochastic factors have been shown to influence telomere attrition. In particular oxidative stress has been reported to play an important role on the process. Uncoupling proteins (UCPs) are among the most important regulators of cellular metabolism and oxidative stress. Several authors investigated the association of UCP genetic variants with leucocyte telomere length (LTL) in both healthy and unhealthy (affected by diabetes) subjects, reporting contrasting results...
March 9, 2017: Biogerontology
https://www.readbyqxmd.com/read/28258519/sirtuins-a-promising-target-in-slowing-down-the-ageing-process
#6
REVIEW
Wioleta Grabowska, Ewa Sikora, Anna Bielak-Zmijewska
Ageing is a plastic process and can be successfully modulated by some biomedical approaches or pharmaceutics. In this manner it is possible to delay or even prevent some age-related pathologies. There are some defined interventions, which give promising results in animal models or even in human studies, resulting in lifespan elongation or healthspan improvement. One of the most promising targets for anti-ageing approaches are proteins belonging to the sirtuin family. Sirtuins were originally discovered as transcription repressors in yeast, however, nowadays they are known to occur in bacteria and eukaryotes (including mammals)...
March 3, 2017: Biogerontology
https://www.readbyqxmd.com/read/28255823/aging-frailty-and-complex-networks
#7
REVIEW
A B Mitnitski, A D Rutenberg, S Farrell, K Rockwood
When people age their mortality rate increases exponentially, following Gompertz's law. Even so, individuals do not die from old age. Instead, they accumulate age-related illnesses and conditions and so become increasingly vulnerable to death from various external and internal stressors. As a measure of such vulnerability, frailty can be quantified using the frailty index (FI). Larger values of the FI are strongly associated with mortality and other adverse health outcomes. This association, and the insensitivity of the FI to the particular health variables that are included in its construction, makes it a powerful, convenient, and increasingly popular integrative health measure...
March 2, 2017: Biogerontology
https://www.readbyqxmd.com/read/28251407/jujube-ziziphus-jujuba-mill-fruit-feeding-extends-lifespan-and-increases-tolerance-to-environmental-stresses-by-regulating-aging-associated-gene-expression-in-drosophila
#8
Saurav Ghimire, Man Su Kim
Jujube (Ziziphus Jujuba Mill.) fruit has been utilized as an adjunct to alleviate medical symptoms including, but not limited to, anorexia, fatigue, anxiety and mild diarrhea for centuries. Despite a growing body of literature revealing jujube fruit's health promoting properties such as anti-cancer, anti-inflammation and anti-oxidant effects (shown with cell-based in vitro platforms), there is a paucity of studies systemically examining its impact on whole organisms or throughout the entire course of life utilizing in vivo model systems...
March 1, 2017: Biogerontology
https://www.readbyqxmd.com/read/28251406/combining-three-mild-stresses-in-drosophila-melanogaster-flies-does-not-have-a-more-positive-effect-on-resistance-to-a-severe-cold-stress-than-combining-two-mild-stresses
#9
Éric Le Bourg
Among other positive effects, mild stresses can increase resistance to severe stresses. Previous studies combining two mild stresses showed that when each mild stress had positive effects their combination had more positive effects than each mild stress. The present study tested whether combining three mild stresses could still provide positive additive effects, or whether this combination has negative effects because it is no longer a mild stress but rather a strong stress with negative effects. Flies were subjected to either fasting, hypergravity for one or two weeks, or cold shocks, to combinations of two or of the three mild stresses, and survival to a severe cold stress was observed at 13 or 20 days of age...
March 1, 2017: Biogerontology
https://www.readbyqxmd.com/read/28251405/differential-decrease-in-soluble-and-dna-bound-telomerase-in-senescent-human-fibroblasts
#10
Snir Yehuda, Hagai Yanai, Esther Priel, Vadim E Fraifeld
The role of telomere shortening in the induction of replicative cellular senescence (CS) is well known and as a result, the involvement of telomerase and in particular its catalytic subunit, the telomerase reverse transcriptase (TERT) in CS has also been investigated. However, the majority of studies were conducted on cells that generally express high levels of TERT (cancer and immortalized cells) while the role of telomerase in CS in normal cells has been investigated to a much lesser extent. In particular, it was reported that active TERT is expressed in early passages of cultured human keratinocytes but rapidly diminished towards entry to CS, without telomere shortening...
March 1, 2017: Biogerontology
https://www.readbyqxmd.com/read/28229255/nordic-walking-training-attenuation-of-oxidative-stress-in-association-with-a-drop-in-body-iron-stores-in-elderly-women
#11
Jakub Kortas, Agnieszka Kuchta, Krzysztof Prusik, Katarzyna Prusik, Ewa Ziemann, Sandra Labudda, Agnieszka Ćwiklińska, Ewa Wieczorek, Maciej Jankowski, Jedrzej Antosiewicz
Excess body iron accumulation and oxidative stress has been associated with ageing. Regular exercise has been shown to reduce oxidative stress and induce some changes in iron metabolism. However, the effects of exercise on both of these parameters have been poorly investigated. In our study, 35 elderly women participated in 12 weeks of Nordic walking (NW) training (three times a week). We demonstrated that the training caused a significant reduction in malondialdehyde advanced oxidation protein products-markers of oxidative stress but had no effects on paraoxonase 1 activity...
February 22, 2017: Biogerontology
https://www.readbyqxmd.com/read/28220304/immunosenescence-and-cancer
#12
Graham Pawelec
Age is a major risk factor for solid cancers, hitherto conventionally viewed in the context of the cell biology of carcinogenesis. However, if cancers are immunogenic, the immune system could protect against tumorigenesis ("immunosurveillance"), and vaccination or other immunomodulatory treatments should be therapeutically beneficial, as has been recently dramatically documented in a fraction of patients with certain tumors responding to immune checkpoint blockade. This begs the question that if immunity decreases with age ("immunosenescence"), this may contribute to increased cancer disease in the elderly and a lower likelihood of clinical benefit from immunotherapy...
February 20, 2017: Biogerontology
https://www.readbyqxmd.com/read/28185019/biological-ageing-and-clinical-consequences-of-modern-technology
#13
Marios Kyriazis
The pace of technology is steadily increasing, and this has a widespread effect on all areas of health and society. When we interact with this technological environment we are exposed to a wide variety of new stimuli and challenges, which may modulate the stress response and thus change the way we respond and adapt. In this Opinion paper I will examine certain aspects of the human-computer interaction with regards to health and ageing. There are practical, everyday effects which also include social and cultural elements...
February 9, 2017: Biogerontology
https://www.readbyqxmd.com/read/28160113/multidimensional-predictors-of-physical-frailty-in-older-people-identifying-how-and-for-whom-they-exert-their-effects
#14
Yew Y Ding, Jouni Kuha, Michael Murphy
Physical frailty in older people is an escalating health and social challenge. We investigate its physical, psychological, and social predictors, including how and for whom these conditions exert their effects. For 4638 respondents aged 65-89 years from wave 2 of the English Longitudinal Study of Ageing, we examine prediction of future physical frailty by physical, psychological, and social conditions using latent growth curve analysis with multiple indicators. In addition, we explore their indirect effects through disease and physiologic decline, and repeat these analyses after stratification by gender, age group, and selected conditions which are possible moderators...
February 3, 2017: Biogerontology
https://www.readbyqxmd.com/read/28116571/in-memory-of-dr-olivier-toussaint
#15
EDITORIAL
Florence Debacq-Chainiaux, João Pedro de Magalhães
No abstract text is available yet for this article.
January 23, 2017: Biogerontology
https://www.readbyqxmd.com/read/28101820/insulin-insulin-like-growth-factor-1-signalling-iis-based-regulation-of-lifespan-across-species
#16
REVIEW
Rebecca Mathew, Manika Pal Bhadra, Utpal Bhadra
An organism's well-being is facilitated by numerous molecular and biochemical pathways that ensure homeostasis within cells and tissues. Aging causes a gradual let-down in the maintenance of homeostasis due to various endogenous and environmental challenges, leading to amassing of damages, functional deterioration of different tissues and vulnerability to ailments. Nutrient sensing pathways that maintain glucose homeostasis in body are involved in regulation of aging. Insulin/insulin-like growth factor-1 (IGF-1) signalling (IIS) pathway was the first nutrient sensing pathway discovered to affect the aging process...
January 18, 2017: Biogerontology
https://www.readbyqxmd.com/read/28093691/middle-age-enhances-expression-of-innate-immunity-genes-in-a-female-mouse-model-of-pulmonary-fibrosis
#17
Marcin Golec, Matthias Wielscher, Marta Kinga Lemieszek, Klemens Vierlinger, Czesława Skórska, Sophia Huetter, Jolanta Sitkowska, Barbara Mackiewicz, Anna Góra-Florek, Rolf Ziesche, Hagai Yanai, Vadim E Fraifeld, Janusz Milanowski, Jacek Dutkiewicz
The lungs are highly sensitive to tissue fibrosis, with a clear age-related component. Among the possible triggers of pulmonary fibrosis are repeated inhalations of fine organic particles. How age affects this response, is still far from being fully understood. We examined the impact of middle-age on gene expression in pulmonary fibrosis, using the novel "inhalation challenge set" mouse model. Our results demonstrate that the response of female mice to exposure of Pantoea agglomerans extract primarily involves various immune-related pathways and cell-cell/cell-extracellular matrix interactions...
January 16, 2017: Biogerontology
https://www.readbyqxmd.com/read/28074309/helicobacter-pylori-induced-premature-senescence-of-extragastric-cells-may-contribute-to-chronic-skin-diseases
#18
Anna Lewinska, Maciej Wnuk
Helicobacter pylori, one of the most frequently observed bacterium in the human intestinal flora, has been widely studied since Marshall and Warren documented a link between the presence of H. pylori in the gastrointestinal tract and gastritis and gastric ulcers. Interestingly, H. pylori has also been found in several other epithelial tissues, including the eyes, ears, nose and skin that may have direct or indirect effects on host physiology and may contribute to extragastric diseases, e.g. chronic skin diseases...
January 10, 2017: Biogerontology
https://www.readbyqxmd.com/read/28039571/identification-of-a-previously-undetected-metabolic-defect-in-the-complex-ii-caenorhabditis-elegans-mev-1-mutant-strain-using-respiratory-control-analysis
#19
Sheng Fong, Li Fang Ng, Li Theng Ng, Philip K Moore, Barry Halliwell, Jan Gruber
Hypometabolism may play an important role in the pathogenesis of ageing and ageing-related diseases. The nematode Caenorhabditis elegans offers the opportunity to study "living mitochondria" in a small (~1 mm) animal replete with a highly stereotypical, yet complex, anatomy and physiology. Basal oxygen consumption rate is often employed as a proxy for energy metabolism in this context. This parameter is traditionally measured using single-chamber Clark electrodes without the addition of metabolic modulators...
December 30, 2016: Biogerontology
https://www.readbyqxmd.com/read/28039570/different-transcriptional-profiling-between-senescent-and-non-senescent-human-coronary-artery-endothelial-cells-hcaecs-by-omeprazole-and-lansoprazole-treatment
#20
Laura Costarelli, Robertina Giacconi, Marco Malavolta, Andrea Basso, Francesco Piacenza, Mauro Provinciali, Marcello G Maggio, Andrea Corsonello, Fabrizia Lattanzio
Recent evidence suggests that high dose and/or long term use of proton pump inhibitors (PPIs) may increase the risk of adverse cardiovascular events in older patients, but mechanisms underlying these detrimental effects are not known. Taking into account that the senescent endothelial cells have been implicated in the genesis or promotion of age-related cardiovascular disease, we hypothesized an active role of PPIs in senescent cells. The aim of this study is to investigate the changes in gene expression occurring in senescent and non-senescent human coronary artery endothelial cells (HCAECs) following Omeprazole (OPZ) or Lansoprazole (LPZ) treatment...
December 30, 2016: Biogerontology
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