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Biogerontology

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https://www.readbyqxmd.com/read/28965259/sexual-activity-affects-the-redox-profile-along-the-aging-process-in-male-rats
#1
Tiago Boeira Salomon, Mara Silveira Benfato
The disposable soma theory postulates that aging might be the result of tradeoffs between early life reproduction and longevity, thereby involving the costs of reproduction in the expected lifespan. It is known that redox biochemistry plays a major role in these processes. To assess long term effects of reproduction, we analyzed redox rates and the testosterone levels at four different ages, and we performed a principal component analysis between redox measures of five different organs followed by a cluster analysis to determine correlations...
September 30, 2017: Biogerontology
https://www.readbyqxmd.com/read/28914388/diet-has-independent-effects-on-the-pace-and-shape-of-aging-in-drosophila-melanogaster
#2
C Ruth Archer, Ugofilippo Basellini, John Hunt, Stephen J Simpson, Kwang Pum Lee, Annette Baudisch
Studies examining how diet affects mortality risk over age typically characterise mortality using parameters such as aging rates, which condense how much and how quickly the risk of dying changes over time into a single measure. Demographers have suggested that decoupling the tempo and the magnitude of changing mortality risk may facilitate comparative analyses of mortality trajectories, but it is unclear what biologically meaningful information this approach offers. Here, we determine how the amount and ratio of protein and carbohydrate ingested by female Drosophila melanogaster affects how much mortality risk increases over a time-standardised life-course (the shape of aging) and the tempo at which animals live and die (the pace of aging)...
September 15, 2017: Biogerontology
https://www.readbyqxmd.com/read/28900770/how-regularities-of-mortality-statistics-explain-why-we-age-despite-having-potentially-ageless-somatic-stem-cells
#3
Alexander V Khalyavkin, Vyacheslav N Krut'ko
Researchers working in the area of ageing have found numerous manifestations of this process at the molecular biological level, including DNA and protein damage, accumulation of metabolic by-products, lipids peroxidation, macromolecular cross-linking, non-enzymatic glycosylation, anti-oxidant/pro-oxidant misbalance, rising of pro-inflammatory cytokines, etc. This results in an increase in the proportion of cells in growth arrest, reduction of the rate of information processing, metabolic rate decrease, and decrease in rates of other processes characterizing dynamic aspects of the organism's interaction with its environment...
September 12, 2017: Biogerontology
https://www.readbyqxmd.com/read/28884409/chronic-exposure-to-rapamycin-and-episodic-serum-starvation-modulate-ageing-of-human-fibroblasts-in-vitro
#4
Lakshman Sodagam, Anna Lewinska, Maciej Wnuk, Suresh I S Rattan
Mild stress-induced activation of stress response (SR) pathways, such as autophagy, heat shock response, oxidative SR, DNA damage response, and inflammatory response, can be potentially health beneficial. Using the model system of cellular ageing and replicative senescence in vitro, we have studied the ageing modulatory effects of the two conditions, rapamycin and serum starvation. Chronic exposure to 0.1, 1 and 10 nM rapamycin positively modulated the survival, growth, morphology, telomere length, DNA methylation levels, 8-oxo-dG level in DNA, N(6)-methyl-adenosine level in RNA, and ethanol stress tolerance of serially passaged normal human skin fibroblasts...
September 7, 2017: Biogerontology
https://www.readbyqxmd.com/read/28849291/senescence-is-not-inevitable
#5
Owen R Jones, James W Vaupel
Senescence, the physiological deterioration resulting in an increase in mortality and decline in fertility with age, is widespread in the animal kingdom and has often been regarded as an inescapable feature of all organisms. This essay briefly describes the history of the evolutionary theoretical ideas on senescence. The canonical evolutionary theories suggest that increasing mortality and decreasing fertility should be ubiquitous. However, increasing empirical data demonstrates that senescence may not be as universal a feature of life as once thought and that a diversity of demographic trajectories exists...
August 28, 2017: Biogerontology
https://www.readbyqxmd.com/read/28825141/sex-as-a-determinant-of-age-related-changes-in-rat-spinal-cord-inflammation-oxidation-state
#6
Mirjana Nacka-Aleksić, Marija Stojanović, Lidija Simić, Biljana Bufan, Jelena Kotur-Stevuljević, Zorica Stojić-Vukanić, Mirjana Dimitrijević, Slavica Ražić, Gordana Leposavić
To close the gap in our knowledge of sex influence on age-related changes in inflammation-oxidation state in spinal cord (SC) relevant to inflammation/oxidative-stress associated neuropathologies, 2-3 month-old (young) and 18-20 month-old (old) rats, exhibiting increased level of IL-6, a commonly used marker of inflamm-aging, were examined for inflammatory/redox status, and the underlying regulatory networks' molecules expression. With age, rat SC microglia became sensitized ("primed"), while SC tissue shifted towards mild inflammatory state, with increased levels of proinflammatory IL-1β (key marker of microglial systemic inflammation-induced neurotoxicity), which was more prominent in males...
August 19, 2017: Biogerontology
https://www.readbyqxmd.com/read/28808816/a-genome-wide-association-study-of-cognitive-function-in-chinese-adult-twins
#7
Chunsheng Xu, Dongfeng Zhang, Yili Wu, Xiaocao Tian, Zengchang Pang, Shuxia Li, Qihua Tan
Multiple loci or genes have been identified using genome-wide association studies mainly in western countries but with inconsistent results. No similar studies have been conducted in the world's largest and rapidly aging Chinese population. The paper aimed to identify the specific genetic variants associated with cognitive function in middle and old-aged Chinese dizygotic twins (DZ). Cognitive function was measured on 139 pairs of DZ by Montreal Cognitive Assessment. The subjects were genotyped at 1048575 SNP positions...
August 14, 2017: Biogerontology
https://www.readbyqxmd.com/read/28795262/growth-factor-energy-and-nutrient-sensing-signalling-pathways-in-metabolic-ageing
#8
Lucia Bettedi, Lazaros C Foukas
The field of the biology of ageing has received increasing attention from a biomedical point of view over the past decades. The main reason has been the realisation that increases in human population life expectancy are accompanied by late onset diseases. Indeed, ageing is the most important risk factor for a number of neoplastic, neurodegenerative and metabolic pathologies. Advances in the knowledge of the genetics of ageing, mainly through research in model organisms, have implicated various cellular processes and the respective signalling pathways that regulate them in cellular and organismal ageing...
August 9, 2017: Biogerontology
https://www.readbyqxmd.com/read/28741183/reproduction-ageing-and-longevity-in-two-species-of-laboratory-rodents-with-different-life-histories
#9
Eugene Novikov, I Zadubrovskaya, P Zadubrovskiy, T Titova
Social subterranean rodents of the Bathyergidae family are known to have extended longevity and some signs of negligible senescence, although the manifestation of these traits depends on the reproductive status of individuals. Such enormous life history peculiarities are usually explained by the specificity of a subterranean way of life. If so, all subterranean rodents, regardless of their taxonomic position, are expected to have higher maximum lifespans and shorter senescence periods than the related above-ground species...
July 24, 2017: Biogerontology
https://www.readbyqxmd.com/read/28687893/erratum-to-the-role-of-gender-and-labour-status-in-immunosenescence-of-65-polish-population
#10
Magdalena Dudkowska, Dorota Janiszewska, Anna Karpa, Katarzyna Broczek, Michal Dabrowski, Ewa Sikora
No abstract text is available yet for this article.
August 2017: Biogerontology
https://www.readbyqxmd.com/read/28681276/the-future-of-ageing-not-more-of-the-same
#11
EDITORIAL
Ewa Sikora, Suresh I S Rattan
No abstract text is available yet for this article.
August 2017: Biogerontology
https://www.readbyqxmd.com/read/28643190/mitochondrial-biogenesis-and-neural-differentiation-of-human-ipsc-is-modulated-by-idebenone-in-a-developmental-stage-dependent-manner
#12
J Augustyniak, J Lenart, M Zychowicz, P P Stepien, L Buzanska
Idebenone, the synthetic analog of coenzyme Q10 can improve electron transport in mitochondria. Therefore, it is used in the treatment of Alzheimer's disease and other cognitive impairments. However, the mechanism of its action on neurodevelopment is still to be elucidated. Here we demonstrate that the cellular response of human induced pluripotent stem cells (hiPSC) to idebenone depends on the stage of neural differentiation. When: neural stem cells (NSC), early neural progenitors (eNP) and advanced neural progenitors (NP) have been studied a significant stimulation of mitochondrial biogenesis was observed only at the eNP stage of development...
August 2017: Biogerontology
https://www.readbyqxmd.com/read/28634926/aging-effect-on-the-instrumented-timed-up-and-go-test-variables-in-nursing-home-women-aged-80-93%C3%A2-years
#13
Ryszard Zarzeczny, Agnieszka Nawrat-Szołtysik, Anna Polak, Jakub Maliszewski, Adam Kiełtyka, Beata Matyja, Magdalena Dudek, Joanna Zborowska, Adam Wajdman
Although the total "Timed-Up-and Go" test (TUG) performance time can characterize an age-related decline of general mobility, this result alone doesn't give any detailed information about the test subtasks. The primary objective of the study was to identify in nursing home women a variable extracted from instrumented TUG (iTUG) that is the best predictor of age. The secondary objective was to assess whether this variable is associated with the results of the isometric knee extension peak torque (IKEPT); lower limb strength measured by the 30-s chair stand test (30sCST), and walking capacity measured by the 6-min walk test (6MWT)...
August 2017: Biogerontology
https://www.readbyqxmd.com/read/28624982/towards-ageing-well-use-it-or-lose-it-exercise-epigenetics-and-cognition
#14
Irene Maeve Rea
More and more people are living into the 90s or becoming centenarians. But, the gift of increased 'age span' seldom equates with an improved 'health-span'. Governments across the world are expressing concern about the epidemic of chronic disease, and have responded by initiating policies that make prevention, reduction and treatment of chronic disease, a public health priority. But understanding, how to age long and well, with the avoidance of chronic disease and later life complex disease morbidity is challenging...
August 2017: Biogerontology
https://www.readbyqxmd.com/read/28612154/frailty-phenotype-and-the-role-of-levodopa-challenge-test-in-geriatric-inpatients-with-mild-parkinsonian-signs
#15
Piotr Seiffert, Jarosław Derejczyk, Jacek Kawa, Czesław Marcisz, Małgorzata Czernek, Jan Szymszal, Wojciech Kapko, Monika Bugdol, Anna Torbus, Olga Stępień-Wyrobiec
Deficiency in dopaminergic system function may be one of the hypothetical reasons of the frailty syndrome but its role still remains unclear. The aim of our study was to assess the frailty phenotype prevalence in geriatric inpatients with mild parkinsonian signs (MPS) and to investigate levodopa test in the frail patients with MPS. We examined 118 participants: 90 with MPS and 28 in control group (without MPS). The frailty syndrome presence was evaluated by the Fried criteria. Deficiency in dopaminergic system function was assessed by one of the modifications of an acute levodopa challenge test (LCT): in MPS group every patient was examined by performing Up and Go Test and also Step Test before and 3 h after taking 125 mg of Madopar (levodopa + benserazide)...
August 2017: Biogerontology
https://www.readbyqxmd.com/read/28573417/convergent-adaptation-of-cellular-machineries-in-the-evolution-of-large-body-masses-and-long-life-spans
#16
REVIEW
Eleonora Croco, Silvia Marchionni, Gianluca Storci, Massimiliano Bonafè, Claudio Franceschi, Thomas D Stamato, Christian Sell, Antonello Lorenzini
In evolutionary terms, life on the planet has taken the form of independently living cells for the majority of time. In comparison, the mammalian radiation is a relatively recent event. The common mammalian ancestor was probably small and short-lived. The "recent" acquisition of an extended longevity and large body mass of some species of mammals present on the earth today suggests the possibility that similar cellular mechanisms have been influenced by the forces of natural selection to create a convergent evolution of longevity...
August 2017: Biogerontology
https://www.readbyqxmd.com/read/28573416/the-budding-yeast-saccharomyces-cerevisiae-as-a-model-organism-possible-implications-for-gerontological-studies
#17
Tomasz Bilinski, Aneta Bylak, Renata Zadrag-Tecza
Experimental gerontology is based on the fundamental assumption that the aging process has a universal character and that the mechanisms of aging are well-conserved among living things. The consequence of this assumption is the use of various organisms, including unicellular yeast Saccharomyces cerevisiae, as models in gerontology, and direct extrapolation of the conclusions drawn from the studies carried on these organisms to human beings. However, numerous arguments suggest that aging is not universal and its mechanisms are not conserved in a wide range of species...
August 2017: Biogerontology
https://www.readbyqxmd.com/read/28444479/the-role-of-gender-and-labour-status-in-immunosenescence-of-65-polish-population
#18
Magdalena Dudkowska, Dorota Janiszewska, Anna Karpa, Katarzyna Broczek, Michal Dabrowski, Ewa Sikora
Women are living longer than men and it seems that one of the reasons could be better immune system of females. In Poland, contrary to many European countries, women retire earlier than men, namely at 60 and 65, respectively. We asked the question how the gender and labour status were interconnected with some immunological parameters included in the so called immune risk profile (IRP), such as CD4+/CD8+ ratio, percentage of CD8+CD28-, and NK, and the level of circulating cytokines. A total of 92 men and 100 women past the retirement age, namely 65-74 years old, still working or not, were examined...
August 2017: Biogerontology
https://www.readbyqxmd.com/read/28421328/association-of-adiponectin-leptin-and-resistin-with-inflammatory-markers-and-obesity-in-dementia
#19
Małgorzata Bednarska-Makaruk, Ałła Graban, Anna Wiśniewska, Wanda Łojkowska, Anna Bochyńska, Magdalena Gugała-Iwaniuk, Ksenia Sławińska, Agnieszka Ługowska, Danuta Ryglewicz, Hanna Wehr
The aim of the study was to determine the role of adiponectin, leptin and resistin in various types of dementia and to investigate their association with inflammatory markers, insulin resistance and abdominal obesity. In 205 patients with dementia [89 with Alzheimer's disease (AD), 47 with vascular dementia (VaD), 69 with mixed dementia (MD)], 113 persons with mild cognitive impairment and in 107 controls serum adiponectin, leptin and resistin levels, pro-inflammatory [interleukin-6 (IL-6), C-reactive protein (hsCRP) and chitotriosidase] and anti-inflammatory (25-OH vitamin D, HDL-cholesterol and paraoxonase 1) markers, as well as glucose metabolism parameters (glucose, insulin and HOMA-IR) were determined...
August 2017: Biogerontology
https://www.readbyqxmd.com/read/28352958/the-epigenetic-landscape-of-age-related-diseases-the-geroscience-perspective
#20
Noémie Gensous, Maria Giulia Bacalini, Chiara Pirazzini, Elena Marasco, Cristina Giuliani, Francesco Ravaioli, Giacomo Mengozzi, Claudia Bertarelli, Maria Giustina Palmas, Claudio Franceschi, Paolo Garagnani
In this review, we summarize current knowledge regarding the epigenetics of age-related diseases, focusing on those studies that have described DNA methylation landscape in cardio-vascular diseases, musculoskeletal function and frailty. We stress the importance of adopting the conceptual framework of "geroscience", which starts from the observation that advanced age is the major risk factor for several of these pathologies and aims at identifying the mechanistic links between aging and age-related diseases...
August 2017: Biogerontology
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