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Biogerontology

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https://www.readbyqxmd.com/read/28702744/plant-extracts-and-natural-compounds-used-against-uvb-induced-photoaging
#1
REVIEW
Maria Cavinato, Birgit Waltenberger, Giorgia Baraldo, Carla V C Grade, Hermann Stuppner, Pidder Jansen-Dürr
Skin is continuously exposed to a variety of environmental stresses, including ultraviolet (UV) radiation. UVB is an inherent component of sunlight that crosses the epidermis and reaches the upper dermis, leading to increased oxidative stress, activation of inflammatory response and accumulation of DNA damage among other effects. The increase in UVB radiation on earth due to the destruction of stratospheric ozone poses a major environmental threat to the skin, increasing the risk of damage with long-term consequences, such as photoaging and photocarcinogenesis...
July 12, 2017: Biogerontology
https://www.readbyqxmd.com/read/28687893/erratum-to-the-role-of-gender-and-labour-status-in-immunosenescence-of-65-polish-population
#2
Magdalena Dudkowska, Dorota Janiszewska, Anna Karpa, Katarzyna Broczek, Michal Dabrowski, Ewa Sikora
No abstract text is available yet for this article.
July 7, 2017: Biogerontology
https://www.readbyqxmd.com/read/28681276/the-future-of-ageing-not-more-of-the-same
#3
EDITORIAL
Ewa Sikora, Suresh I S Rattan
No abstract text is available yet for this article.
July 5, 2017: Biogerontology
https://www.readbyqxmd.com/read/28677014/a-mild-cold-stress-that-increases-resistance-to-heat-lowers-foxo-translocation-in-drosophila-melanogaster
#4
Cédric Polesello, Eric Le Bourg
Previous studies have shown that subjecting Drosophila melanogaster flies to a mild stress at young or middle age can increase lifespan and resistance to severe stresses throughout life and that the NF-κB-like transcription factor DIF, the 70 kDa heat-shock proteins, and the Drosophila Forkhead box class O (dFOXO) transcription factor could explain some of these effects. The present study showed that two dFOXO mutants do not survive longer heat if previously subjected to a mild cold stress, contrarily to wild-type flies...
July 4, 2017: Biogerontology
https://www.readbyqxmd.com/read/28643190/mitochondrial-biogenesis-and-neural-differentiation-of-human-ipsc-is-modulated-by-idebenone-in-a-developmental-stage-dependent-manner
#5
J Augustyniak, J Lenart, M Zychowicz, P P Stepien, L Buzanska
Idebenone, the synthetic analog of coenzyme Q10 can improve electron transport in mitochondria. Therefore, it is used in the treatment of Alzheimer's disease and other cognitive impairments. However, the mechanism of its action on neurodevelopment is still to be elucidated. Here we demonstrate that the cellular response of human induced pluripotent stem cells (hiPSC) to idebenone depends on the stage of neural differentiation. When: neural stem cells (NSC), early neural progenitors (eNP) and advanced neural progenitors (NP) have been studied a significant stimulation of mitochondrial biogenesis was observed only at the eNP stage of development...
June 22, 2017: Biogerontology
https://www.readbyqxmd.com/read/28634926/aging-effect-on-the-instrumented-timed-up-and-go-test-variables-in-nursing-home-women-aged-80-93%C3%A2-years
#6
Ryszard Zarzeczny, Agnieszka Nawrat-Szołtysik, Anna Polak, Jakub Maliszewski, Adam Kiełtyka, Beata Matyja, Magdalena Dudek, Joanna Zborowska, Adam Wajdman
Although the total "Timed-Up-and Go" test (TUG) performance time can characterize an age-related decline of general mobility, this result alone doesn't give any detailed information about the test subtasks. The primary objective of the study was to identify in nursing home women a variable extracted from instrumented TUG (iTUG) that is the best predictor of age. The secondary objective was to assess whether this variable is associated with the results of the isometric knee extension peak torque (IKEPT); lower limb strength measured by the 30-s chair stand test (30sCST), and walking capacity measured by the 6-min walk test (6MWT)...
June 20, 2017: Biogerontology
https://www.readbyqxmd.com/read/28624982/towards-ageing-well-use-it-or-lose-it-exercise-epigenetics-and-cognition
#7
Irene Maeve Rea
More and more people are living into the 90s or becoming centenarians. But, the gift of increased 'age span' seldom equates with an improved 'health-span'. Governments across the world are expressing concern about the epidemic of chronic disease, and have responded by initiating policies that make prevention, reduction and treatment of chronic disease, a public health priority. But understanding, how to age long and well, with the avoidance of chronic disease and later life complex disease morbidity is challenging...
June 17, 2017: Biogerontology
https://www.readbyqxmd.com/read/28612154/frailty-phenotype-and-the-role-of-levodopa-challenge-test-in-geriatric-inpatients-with-mild-parkinsonian-signs
#8
Piotr Seiffert, Jarosław Derejczyk, Jacek Kawa, Czesław Marcisz, Małgorzata Czernek, Jan Szymszal, Wojciech Kapko, Monika Bugdol, Anna Torbus, Olga Stępień-Wyrobiec
Deficiency in dopaminergic system function may be one of the hypothetical reasons of the frailty syndrome but its role still remains unclear. The aim of our study was to assess the frailty phenotype prevalence in geriatric inpatients with mild parkinsonian signs (MPS) and to investigate levodopa test in the frail patients with MPS. We examined 118 participants: 90 with MPS and 28 in control group (without MPS). The frailty syndrome presence was evaluated by the Fried criteria. Deficiency in dopaminergic system function was assessed by one of the modifications of an acute levodopa challenge test (LCT): in MPS group every patient was examined by performing Up and Go Test and also Step Test before and 3 h after taking 125 mg of Madopar (levodopa + benserazide)...
June 13, 2017: Biogerontology
https://www.readbyqxmd.com/read/28597407/resistance-wheel-exercise-from-mid-life-has-minimal-effect-on-sciatic-nerves-from-old-mice-in-which-sarcopenia-was-prevented
#9
Vidya S Krishnan, Zoe White, Jessica R Terrill, Stuart I Hodgetts, Melinda Fitzgerald, Tea Shavlakadze, Alan R Harvey, Miranda D Grounds
The ability of resistance exercise, initiated from mid-life, to prevent age-related changes in old sciatic nerves, was investigated in male and female C57BL/6J mice. Aging is associated with cellular changes in old sciatic nerves and also loss of skeletal muscle mass and function (sarcopenia). Mature adult mice aged 15 months (M) were subjected to increasing voluntary resistance wheel exercise (RWE) over a period of 8 M until 23 M of age. This prevented sarcopenia in the old 23 M aged male and female mice...
June 8, 2017: Biogerontology
https://www.readbyqxmd.com/read/28577110/daily-chronomics-of-proteomic-profile-in-aging-and-rotenone-induced-parkinson-s-disease-model-in-male-wistar-rat-and-its-modulation-by-melatonin
#10
Anita Jagota, Ushodaya Mattam
Aging is associated with changes in several basic parameters of circadian timing system (CTS) in mammals leading to circadian dysfunction. We had reported earlier that upon aging and in rotenone induced Parkinson's disease (RIPD) rat model there were significant alterations in the core clock genes expression levels and daily pulses. To identify biomarkers of aging and PD chronomics of proteomic day-night profiles in suprachiasmatic nucleus (SCN), pineal and substantia nigra (SN) in 3 month (m), 12, 24 m and RIPD rat model were studied at two time points i...
June 2, 2017: Biogerontology
https://www.readbyqxmd.com/read/28573417/convergent-adaptation-of-cellular-machineries-in-the-evolution-of-large-body-masses-and-long-life-spans
#11
REVIEW
Eleonora Croco, Silvia Marchionni, Gianluca Storci, Massimiliano Bonafè, Claudio Franceschi, Thomas D Stamato, Christian Sell, Antonello Lorenzini
In evolutionary terms, life on the planet has taken the form of independently living cells for the majority of time. In comparison, the mammalian radiation is a relatively recent event. The common mammalian ancestor was probably small and short-lived. The "recent" acquisition of an extended longevity and large body mass of some species of mammals present on the earth today suggests the possibility that similar cellular mechanisms have been influenced by the forces of natural selection to create a convergent evolution of longevity...
June 1, 2017: Biogerontology
https://www.readbyqxmd.com/read/28573416/the-budding-yeast-saccharomyces-cerevisiae-as-a-model-organism-possible-implications-for-gerontological-studies
#12
Tomasz Bilinski, Aneta Bylak, Renata Zadrag-Tecza
Experimental gerontology is based on the fundamental assumption that the aging process has a universal character and that the mechanisms of aging are well-conserved among living things. The consequence of this assumption is the use of various organisms, including unicellular yeast Saccharomyces cerevisiae, as models in gerontology, and direct extrapolation of the conclusions drawn from the studies carried on these organisms to human beings. However, numerous arguments suggest that aging is not universal and its mechanisms are not conserved in a wide range of species...
June 1, 2017: Biogerontology
https://www.readbyqxmd.com/read/28540446/lipid-per-oxidation-in-mitochondria-an-emerging-target-in-the-ageing-process
#13
REVIEW
O S Ademowo, H K I Dias, D G A Burton, H R Griffiths
Lipids are essential for physiological processes such as maintaining membrane integrity, providing a source of energy and acting as signalling molecules to control processes including cell proliferation, metabolism, inflammation and apoptosis. Disruption of lipid homeostasis can promote pathological changes that contribute towards biological ageing and age-related diseases. Several age-related diseases have been associated with altered lipid metabolism and an elevation in highly damaging lipid peroxidation products; the latter has been ascribed, at least in part, to mitochondrial dysfunction and elevated ROS formation...
May 24, 2017: Biogerontology
https://www.readbyqxmd.com/read/28501895/angiogenesis-is-vegf-independent-in-the-aged-striatum-of-male-rats-exposed-to-acute-hypoxia
#14
Francisco Molina, M Luisa Del Moral, M Ángeles Peinado, Alma Rus
Brain hypoxia is involved in many diseases. The activation of angiogenesis is one of the major adaptive mechanisms to counteract the adverse effects of hypoxia. In a previous work, we have shown that the adult rat striatum promotes angiogenesis in response to hypoxia via upregulation of the most important proangiogenic factor, the vascular endothelial growth factor (VEGF). However, the effects of hypoxia on angiogenesis in the aged striatum remain unknown and constitute our aim. Here we show the upregulation of hypoxia-inducible factor-1α in the striatum of aged (24-25 months old) Wistar rats exposed to acute hypoxia and analysed during a reoxygenation period ranging from 0 h to 5 days...
May 13, 2017: Biogerontology
https://www.readbyqxmd.com/read/28501894/influence-of-ageing-on-the-microarchitecture-of-the-spleen-and-lymph-nodes
#15
REVIEW
Vivian M Turner, Neil A Mabbott
The elderly have a decreased response to vaccination and an increased susceptibility to infectious diseases. The spleen and lymph nodes are important secondary lymphoid organs where immune cells can rapidly respond to pathogenic material in the blood and lymph in order to mount long-term adaptive immune responses to those pathogens. In aged mice and humans structural changes occur to both the spleen and lymph nodes. These structural changes affect the functioning of the immune cells within, which may ultimate result in less effective or decreased immune responses...
May 13, 2017: Biogerontology
https://www.readbyqxmd.com/read/28492999/physical-activity-improves-cognition-possible-explanations
#16
REVIEW
Blanka Koščak Tivadar
Good cognitive abilities (CA) enable autonomy, improve social inclusion and act preventively. Regular physical activity (PA) reduces the risk of developing Alzheimer's disease (AD) and, at the same time, it reduces the decline of CA and stimulates neurogenesis. So PA in connection with cognitive training, nutrition and social interaction has a positive effect on general CA and the central nervous system, the central executor, memory and attention, and reduces the likelihood of developing dementia. Our objective was to examine which sort and intensity of PA is preferred...
May 10, 2017: Biogerontology
https://www.readbyqxmd.com/read/28478492/intermittent-fasting-combined-with-supplementation-with-ayurvedic-herbs-reduces-anxiety-in-middle-aged-female-rats-by-anti-inflammatory-pathways
#17
Harpal Singh, Taranjeet Kaur, Shaffi Manchanda, Gurcharan Kaur
Intermittent fasting-dietary restriction (IF-DR) is an increasingly popular intervention to promote healthy aging and delay age associated decline in brain functions. Also, the use of herbal interventions is gaining attention due to their non-pharmacological approach to treat several abnormalities and promote general health with least side effects. The present study was aimed to investigate the synergistic effects of IF-DR regimen with herbal supplementation on anxiety-like behavior and neuroinflammation in middle aged female rats...
May 6, 2017: Biogerontology
https://www.readbyqxmd.com/read/28477081/exogenous-nicotinamide-supplementation-and-moderate-physical-exercise-can-attenuate-the-aging-process-in-skeletal-muscle-of-rats
#18
Melitta Pajk, Alexandra Cselko, Csaba Varga, Aniko Posa, Margareta Tokodi, Istvan Boldogh, Sataro Goto, Zsolt Radak
Nicotinamide (NAM) could enhance the availability of NAD(+) and be beneficial to cell function. However, NAM can inhibit the activities of SIRT1 and PARP. The effect of NAM supplementation on the aging process is not well known. In the present study exogenous NAM (1-0.5% in drinking water) was supplemented for 5 weeks and in the last 4 weeks moderate treadmill running was given to 5 mo and 28 mo old rats. The content of SIRT1 was not effected by NAM treatment alone. However, the activity of SIRT1, judged from the acetylated p53/p53 ratio, increased in both NAM treated age groups, suggesting beneficial effects of exogenous NAM...
May 5, 2017: Biogerontology
https://www.readbyqxmd.com/read/28466185/tissue-specific-transcription-of-the-neuronal-gene-lim3-affects-drosophila-melanogaster-lifespan-and-locomotion
#19
Olga Y Rybina, Svetlana V Sarantseva, Ekaterina R Veselkina, Olga I Bolschakova, Alexander V Symonenko, Anna V Krementsova, Elena V Ryabova, Natalia V Roshina, Elena G Pasyukova
The identity of neuronal cell types is established and maintained by the expression of neuronal genes coding for ion channels, neurotransmitters, and neuropeptides, among others. Some of these genes have been shown to affect lifespan; however, their role in lifespan control remains largely unclear. The Drosophila melanogaster gene Lim3 encodes a transcription factor involved in complicated motor neuron specification networks. We previously identified Lim3 as a candidate gene affecting lifespan. To obtain direct evidence of the involvement of Lim3 in lifespan control, Lim3 overexpression and RNAi knockdown were induced in the nervous system and muscles of Drosophila using the GAL4-UAS binary system...
May 2, 2017: Biogerontology
https://www.readbyqxmd.com/read/28451923/mifepristone-ru486-acts-in-drosophila-melanogaster-females-to-counteract-the-life-span-shortening-and-pro-inflammatory-effects-of-male-sex-peptide
#20
John Tower, Gary N Landis, Jie Shen, Rachelle Choi, Yang Fan, Dasul Lee, Jaemin Song
Males with null mutation of Sex Peptide (SP) gene were compared to wild-type males for the ability to cause physiological changes in females that could be reversed by mifepristone. Males from wild-type strains decreased median female life span by average -51%. Feeding mifepristone increased life span of these females by average +106%. In contrast, SP-null males did not decrease female life span, and mifepristone increased median life span of these females by average +14%, which was equivalent to the effect of mifepristone in virgin females (average +16%)...
June 2017: Biogerontology
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