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Nordic Journal of Psychiatry

Muruvvet Topaloglu, Erdem Tuzun, Huseyin Gulec, Elif Sinem Bireller, Bedia Cakmakoglu, Cem Ismail Kucukali
BACKGROUND: Obsessive-compulsive disorder (OCD) is a mental disease characterized by recurrent and intrusive thoughts and repetitive behaviours that negatively affect the quality-of-life of the patients. Recent studies have implicated the participation of neuronal nitric oxide in OCD pathogenesis as a neurotransmitter modulator. AIMS: To identify whether variations in neuronal nitric oxide synthase (nNOS) genes may render individuals susceptible to OCD development...
October 14, 2016: Nordic Journal of Psychiatry
Svetlana Oshukova, Riittakerttu Kaltiala-Heino, Matti Kaivosoja, Nina Lindberg
BACKGROUND: In DSM 5, conduct disorder was expanded with the new specifier 'with limited prosocial emotions (LPE)'. These callous-unemotional traits have been emphasized as the 'core' of psychopathy syndrome providing greater information about current and future impairment. Individuals with callous-unemotional traits have shown elevated levels of impairment, and these traits have been suggested to serve as a useful indicator for psychiatric vulnerability and psychosocial maladjustment also among community youth...
October 14, 2016: Nordic Journal of Psychiatry
Vidir Sigrunarson, Inger Elise Opheim Moljord, Aslak Steinsbekk, Lasse Eriksen, Gunnar Morken
BACKGROUND: There has been a call for increased patient autonomy and participation in psychiatry. Some Community Mental Health Centres (CMHC) have implemented services called 'self-referral to inpatient treatment' (SRIT) for patients with severe mental disorders. AIMS: To investigate whether SRIT could yield better outcomes after 12 months in use of mental health services for people with severe mental disorders than Treatment As Usual (TAU). METHODS: This was a randomized controlled trial at a CMHC in Norway comparing SRIT and TAU in 12 months...
October 14, 2016: Nordic Journal of Psychiatry
Hedvig Krona, Marielle Nyman, Helena Andreasson, Nicolas Vicencio, Henrik Anckarsäter, Märta Wallinius, Thomas Nilsson, Björn Hofvander
BACKGROUND: Forensic psychiatric patients present a challenge as they manifest severe mental disorders together with criminal behaviour. There are well-known risk factors for criminal behaviour in the general population, yet knowledge of what predicts reconviction in the Swedish forensic population in the long-term perspective is still insufficient. AIMS: The study aims to (1) describe background and clinical characteristics of forensic psychiatric patients in a 10-year follow-up, (2) analyse risk factors associated with recidivism, and (3) test the predictive validity of risk factors for general and violent criminality...
October 5, 2016: Nordic Journal of Psychiatry
Viacheslav Terevnikov, Jan-Henry Stenberg, Jari Tiihonen, Mark Burkin, Grigori Joffe
AIM: Sexual dysfunction, common in schizophrenia, may be further exaggerated by antipsychotics, especially those of First Generation (FGAs), and antidepressants, such as Selective Serotonin Reuptake Inhibitors (SSRs). Mirtazapine, an antidepressant characterized by its different action mechanism compared with that of the majority of other antidepressants, may improve SSRI-induced sexual dysfunction in patients with depression. It is unknown, however, whether mirtazapine improves sexual functioning in schizophrenia...
October 5, 2016: Nordic Journal of Psychiatry
Morten Tønning, Dorthe Petersen, Marie Steglich-Petersen, Claudio Csillag
BACKGROUND: Body mass index (BMI) and body weight have been shown to be associated to treatment outcome in patients with major depressive disorder, but this relationship is not clear. Visceral fat might be an underlying mechanism explaining this relationship. AIMS: The aim of this study was to prospectively investigate whether visceral fat, as measured by hip-to-waist ratio and waist circumference, affects treatment outcome in patients with major depressive disorder in patients attending a hospital psychiatric care unit in Denmark...
October 5, 2016: Nordic Journal of Psychiatry
Annika Thomson, Jari Tiihonen, Jouko Miettunen, Matti Virkkunen, Nina Lindberg
BACKGROUND: Aggressive and disruptive behaviours often precede the onset of serious mental illnesses. Fire-setting is a type of crime that is associated with psychotic disorders. AIM: The aim of this prospective follow-up study was to investigate if fire-setting performed in adolescence or early adulthood was associated with future diagnoses of schizophrenia or schizoaffective disorder. METHODS: The consecutive sample consisted of 111 Finnish 15-25-year old males with fire-setting crimes, decreed to a pre-trial forensic psychiatric examination in 1973-1998, and showing no past nor current psychosis at the time of examination...
September 27, 2016: Nordic Journal of Psychiatry
Jari-Pekka Klemettilä, Olli Kampman, Niko Seppälä, Merja Viikki, Mari Hämäläinen, Eeva Moilanen, Esa Leinonen
BACKGROUND: Schizophrenia is associated with excess cardiovascular comorbidity and mortality related to lifestyle factors, such as lack of physical activity, poor diet, and smoking. The prevalence of metabolic syndrome is increased among patients with schizophrenia, with the highest rates among patients on clozapine treatment. Smoking, obesity, physical inactivity, airway inflammation and obstruction, and adipose tissue and inflammatory marker activation are related in systemic inflammation...
September 23, 2016: Nordic Journal of Psychiatry
Veera Pohjolainen, Pirjo Räsänen, Risto P Roine, Harri Sintonen, Salla Koponen, Hasse Karlsson
BACKGROUND: The costs of treating eating disorders are often considered high. AIMS: The objective was to perform a cost-utility analysis to estimate the cost-effectiveness of treatment of anorexia nervosa (AN). METHODS: Thirty-nine patients entering treatment of AN completed the 15D health-related quality-of-life (HRQoL) questionnaire before and 2 years after the start of treatment. Direct hospital costs were obtained. Quality-adjusted life years (QALYs) gained were calculated and cost-utility assessed...
September 19, 2016: Nordic Journal of Psychiatry
Niklas Granö, Jorma Oksanen, Santeri Kallionpää, Mikko Roine
Previous studies have shown an association between hopelessness and suicidal behaviour in clinical populations. The aim of the study was to investigate sensitivity, specificity, and predictive validity of the Beck Hopelessness Scale (BHS) for suicidal ideation in adolescents who show early risk signs on the psychiatric disorder continuum. Three-hundred and two help-seeking adolescents (mean age = 15.5 years) who were entering an early intervention team at Helsinki University Central Hospital, Finland, completed questionnaires of BHS and suicidal ideation, derived from Beck Depression Inventory (BDI-II)...
September 14, 2016: Nordic Journal of Psychiatry
Jessi Litmanen, Sari Fröjd, Mauri Marttunen, Rasmus Isomaa, Riittakerttu Kaltiala-Heino
BACKGROUND: A debate concerns whether eating disorders are increasing in prevalence. The role of socio-economic status (SES) for adolescent eating disorders (ED) is another matter of debate. AIMS: To ascertain whether self-reported eating disorders or their symptoms have increased in prevalence in adolescent population from the early 2000s to early 2010s. METHODS: A person-identifiable classroom survey, Adolescent Mental Health Cohort study, was carried out among the 9th graders in comprehensive schools in Tampere, Finland, during academic year 2002-2003, and replicated among then 9th graders during academic years 2012-2013...
September 14, 2016: Nordic Journal of Psychiatry
Li Sun, Ping Xu, Yan-Gang Zhou, Shan-Ru Zuo, Yi-Ping Liu
BACKGROUND: rs6311 and rs6313 polymorphism of 5-hydroxytryptamine 2A receptor has been widely studied regarding association with susceptibility to schizophrenia, but the results remained inconsistent. AIMS: This study aimed to assess the association between rs6311 and rs6313 polymorphism and schizophrenia using a meta-analysis. METHODS: Pubmed, Web of Science, and Embase databases were searched for all articles linking rs6311 and rs6313 polymorphism and schizophrenia...
September 6, 2016: Nordic Journal of Psychiatry
Hasan Belli, Mahir Akbudak, Cenk Ural, Mustafa Solmaz, Zuhal Dogan, Ramazan Konkan
BACKGROUND: A possible relationship has been suggested between social anxiety and dissociation. Traumatic experiences, especially childhood abuse, play an important role in the aetiology of dissociation. AIM: This study assesses childhood trauma history, dissociative symptoms, and dissociative disorder comorbidity in patients with social anxiety disorder (SAD). METHOD: The 94 psychotropic drug-naive patients participating in the study had to meet DSM-IV criteria for SAD...
August 26, 2016: Nordic Journal of Psychiatry
Tomi Virtanen, Saana Eskelinen, Eila Sailas, Jaana Suvisaari
Constipation and dyspepsia are disturbing gastrointestinal symptoms that are often ignored in research on physical comorbidities of schizophrenia. The aim was to assess dyspepsia and constipation in a sample of outpatients with schizophrenia spectrum psychoses. A general practitioner performed a thorough physical health check for 275 outpatients and diagnosed constipation and dyspepsia. This study assessed the possible contribution of several sociodemographic, lifestyle, and clinical variables to constipation and dyspepsia using logistic regression analysis...
August 26, 2016: Nordic Journal of Psychiatry
Ida Kim Wium-Andersen, Maj Vinberg, Lars Vedel Kessing, Roger S McIntyre
BACKGROUND: Personalized medicine is a model in which a patient's unique clinical, genetic, and environmental characteristics are the basis for treatment and prevention. Aim, method, and results: This review aims to describe the current tools, phenomenological features, clinical risk factors, and biomarkers used to provide personalized medicine. Furthermore, this study describes the target areas in which they can be applied including diagnostics, treatment selection and response, assessment of risk of side-effects, and prevention...
August 26, 2016: Nordic Journal of Psychiatry
Achraf Jemli, Oumaima Inoubli, Fatma Trifa, Anouar Mechri, Ferid Zaafrane, Lotfi Gaha, Besma Bel Hadj Jrad
BACKGROUND: Considering current scientific evidence about the significant role of chronic low grade inflammation in the physiopathology of schizophrenia, it has been hypothesized that changes in pro-inflammatory cytokines such as interferon gamma may have a significant role in the predisposition to schizophrenia. AIM: This study focuses on identifying whether the functional polymorphism of interferon gamma receptor 2 (IFNGR2) is a risk factor for the development of schizophrenia...
August 26, 2016: Nordic Journal of Psychiatry
Solveig Osborg Ose, Silje Lill Kaspersen, Ivar Pettersen
BACKGROUND: To obtain more co-ordinated services, better co-operation between the services and more efficient use of resources, a pilot project for transferring some district psychiatric centres (DPCs) to large municipalities is planned by the Norwegian government. Systematic knowledge about the patients involved is needed when clinical needs and standards, funding, and political agendas are discussed. This study identifies the clinical, socio-demographic, and behavioural characteristics of patients who need services from both the municipality and the DPC...
November 2016: Nordic Journal of Psychiatry
Sanjay Lahariya, Sandeep Grover, Shiv Bagga, Akhilesh Sharma
AIM: To study the phenomenology and motor sub-types of delirium in patients admitted in a Coronary Care Unit (CCU). METHODS: Three hundred and nine consecutive patients were screened for delirium, and those found positive for the same were evaluated by a psychiatrist on DSM-IVTR criteria to confirm the diagnosis. Those with a diagnosis of delirium were evaluated on the DRS-R-98 to study the phenomenology and on the amended Delirium Motor Symptom Scale (DMSS) to study the motor sub-types...
November 2016: Nordic Journal of Psychiatry
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November 2016: Nordic Journal of Psychiatry
Marja Kuronen, Hannu Kautiainen, Pertti Karppi, Sirpa Hartikainen, Hannu Koponen
BACKGROUND: Neuropsychiatric symptoms (NPS) in cognitive disorders impair quality of life, increase caregiver stress, and may lead to earlier institutionalization and death. The objective of this study was to investigate the use of antipsychotics among persons with cognitive impairment in home care and residential care, and its associations with NPS and personal characteristics. METHODS: Data were collected in the South Savo Hospital District area with 105 000 inhabitants, where 66 of 68 institutions providing long-term residential care and 20 of 21 municipal home care producers joined the study...
November 2016: Nordic Journal of Psychiatry
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