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Breast Cancer Research: BCR

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https://www.readbyqxmd.com/read/28446206/cooperation-of-neurotrophin-receptor-trkb-and-her2-in-breast-cancer-cells-facilitates-brain-metastases
#1
Cecilia Choy, Khairul I Ansari, Josh Neman, Sarah Hsu, Matthew J Duenas, Hubert Li, Nagarajan Vaidehi, Rahul Jandial
BACKGROUND: Patients with primary breast cancer that is positive for human epidermal growth factor receptor 2 (Her2+) have a high risk of developing metastases in the brain. Despite gains with systemic control of Her2+ disease using molecular therapies, brain metastases remain recalcitrant to therapeutic discovery. The clinical predilection of Her2+ breast cancer cells to colonize the brain likely relies on paracrine mechanisms. The neural niche poses unique selection pressures, and neoplastic cells that utilize the brain microenvironment may have a survival advantage...
April 26, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28427436/a-3d-in-vitro-model-of-the-human-breast-duct-a-method-to-unravel-myoepithelial-luminal-interactions-in-the-progression-of-breast-cancer
#2
Edward P Carter, James A Gopsill, Jennifer J Gomm, J Louise Jones, Richard P Grose
BACKGROUND: 3D modelling fulfils a critical role in research, allowing for complex cell behaviour and interactions to be studied in physiomimetic conditions. With tissue banks becoming established for a number of cancers, researchers now have access to primary patient cells, providing the perfect building blocks to recreate and interrogate intricate cellular systems in the laboratory. The ducts of the human breast are composed of an inner layer of luminal cells supported by an outer layer of myoepithelial cells...
April 21, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28424080/erratum-to-hdac6-activity-is-a-non-oncogene-addiction-hub-for-inflammatory-breast-cancers
#3
Preeti Putcha, Jiyang Yu, Ruth Rodriguez-Barrueco, Laura Saucedo-Cuevas, Patricia Villagrasa, Eva Murga-Penas, Steven N Quayle, Min Yang, Veronica Castro, David Llobet-Navas, Daniel Birnbaum, Pascal Finetti, Wendy A Woodward, François Bertucci, Mary L Alpaugh, Andrea Califano, Jose Silva
No abstract text is available yet for this article.
April 19, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28407814/erratum-to-detecting-gene-signature-activation-in-breast-cancer-in-an-absolute-single-patient-manner
#4
E R Paquet, R Lesurf, A Tofigh, V Dumeaux, M T Hallett
No abstract text is available yet for this article.
April 13, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28399903/overexpression-of-syndecan-1-muc-1-and-putative-stem-cell-markers-in-breast-cancer-leptomeningeal-metastasis-a-cerebrospinal-fluid-flow-cytometry-study
#5
Iole Cordone, Serena Masi, Valentina Summa, Mariantonia Carosi, Antonello Vidiri, Alessandra Fabi, Alessia Pasquale, Laura Conti, Immacolata Rosito, Carmine Maria Carapella, Veronica Villani, Andrea Pace
BACKGROUND: Cancer is a mosaic of tumor cell subpopulations, where only a minority is responsible for disease recurrence and cancer invasiveness. We focused on one of the most aggressive circulating tumor cells (CTCs) which, from the primitive tumor, spreads to the central nervous system (CNS), evaluating the expression of prognostic and putative cancer stem cell markers in breast cancer (BC) leptomeningeal metastasis (LM). METHODS: Flow cytometry immunophenotypic analysis of cerebrospinal fluid (CSF) samples (4...
April 11, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28399902/efficacy-and-safety-of-everolimus-in-combination-with-trastuzumab-and-paclitaxel-in-asian-patients-with-her2-advanced-breast-cancer-in-bolero-1
#6
Masakazu Toi, Zhimin Shao, Sara Hurvitz, Ling-Ming Tseng, Qingyuan Zhang, Kunwei Shen, Donggeng Liu, Jifeng Feng, Binghe Xu, Xiaojia Wang, Keun Seok Lee, Ting Ying Ng, Antonia Ridolfi, Florence Noel-Baron, Francois Ringeisen, Zefei Jiang
BACKGROUND: The current exploratory analysis was performed to evaluate the efficacy and safety of everolimus for treatment of human epidermal growth factor receptor 2-positive (HER2+) advanced breast cancer in the Asian subset of patients in the BOLERO-1 trial. METHODS: Postmenopausal women with HER2+ advanced breast cancer, who had not received systemic therapy for advanced disease, were randomized 2:1 to receive everolimus or placebo, plus trastuzumab and paclitaxel...
April 11, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28381271/association-between-air-pollution-and-mammographic-breast-density-in-the-breast-cancer-surveilance-consortium
#7
Lusine Yaghjyan, Robert Arao, Cole Brokamp, Ellen S O'Meara, Brian L Sprague, Gabriela Ghita, Patrick Ryan
BACKGROUND: Mammographic breast density is a well-established strong risk factor for breast cancer. The environmental contributors to geographic variation in breast density in urban and rural areas are poorly understood. We examined the association between breast density and exposure to ambient air pollutants (particulate matter <2.5 μm in diameter (PM2.5) and ozone (O3)) in a large population-based screening registry. METHODS: Participants included women undergoing mammography screening at imaging facilities within the Breast Cancer Surveillance Consortium (2001-2009)...
April 6, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28359319/endocrine-therapy-initiation-discontinuation-and-adherence-and-breast-imaging-among-21-gene-recurrence-score-assay-eligible-women-under-age-65
#8
Suzanne C O'Neill, Claudine Isaacs, Filipa Lynce, Deena Mary Atieh Graham, Calvin Chao, Vanessa B Sheppard, Yingjun Zhou, Chunfu Liu, Nandini Selvam, Marc D Schwartz, Arnold L Potosky
BACKGROUND: Aside from chemotherapy utilization, limited data are available on the relationship between gene expression profiling (GEP) testing and breast cancer care. We assessed the relationship between GEP testing and additional variables and the outcomes of endocrine therapy initiation, discontinuation and adherence, and breast imaging exams in women under age 65 years. METHODS: Data from five state cancer registries were linked with claims data and GEP results...
March 31, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28356166/integrative-clustering-reveals-a-novel-split-in-the-luminal-a-subtype-of-breast-cancer-with-impact-on-outcome
#9
Miriam Ragle Aure, Valeria Vitelli, Sandra Jernström, Surendra Kumar, Marit Krohn, Eldri U Due, Tonje Husby Haukaas, Suvi-Katri Leivonen, Hans Kristian Moen Vollan, Torben Lüders, Einar Rødland, Charles J Vaske, Wei Zhao, Elen K Møller, Silje Nord, Guro F Giskeødegård, Tone Frost Bathen, Carlos Caldas, Trine Tramm, Jan Alsner, Jens Overgaard, Jürgen Geisler, Ida R K Bukholm, Bjørn Naume, Ellen Schlichting, Torill Sauer, Gordon B Mills, Rolf Kåresen, Gunhild M Mælandsmo, Ole Christian Lingjærde, Arnoldo Frigessi, Vessela N Kristensen, Anne-Lise Børresen-Dale, Kristine K Sahlberg
BACKGROUND: Breast cancer is a heterogeneous disease at the clinical and molecular level. In this study we integrate classifications extracted from five different molecular levels in order to identify integrated subtypes. METHODS: Tumor tissue from 425 patients with primary breast cancer from the Oslo2 study was cut and blended, and divided into fractions for DNA, RNA and protein isolation and metabolomics, allowing the acquisition of representative and comparable molecular data...
March 29, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28351428/erratum-to-jmjd6-is-a-driver-of-cellular-proliferation-and-motility-and-a-marker-of-poor-prognosis-in-breast-cancer
#10
Yi Fang Lee, Lance David Miller, Xiu Bin Chan, Michael A Black, Brendan Pang, Chee Wee Ong, Manuel Salto-Tellez, Edison T Liu, Kartiki V Desai
No abstract text is available yet for this article.
March 28, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28351421/erratum-to-a-novel-function-for-p21-cip1-and-acetyltransferase-p-caf-as-critical-transcriptional-regulators-of-tgf%C3%AE-mediated-breast-cancer-cell-migration-and-invasion
#11
Meiou Dai, Amal A Al-Odaini, Ani Arakelian, Shafaat A Rabbani, Suhad Ali, Jean-Jacques Lebrun
No abstract text is available yet for this article.
March 28, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28351416/erratum-to-ubiquitin-conjugating-enzyme-complex-uev1a-ubc13-promotes-breast-cancer-metastasis-through-nuclear-factor-%C3%B0%C2%BAb-mediated-matrix-metalloproteinase-1-gene-regulation
#12
Zhaojia Wu, Siqi Shen, Zhiling Zhang, Weiwei Zhang, Wei Xiao
No abstract text is available yet for this article.
March 28, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28351385/erratum-to-cancer-progression-by-breast-tumors-with-pit-1-overexpression-is-blocked-by-inhibition-of-metalloproteinase-mmp-13
#13
Juan Sendon-Lago, Samuel Seoane, Noemi Eiro, Maria A Bermudez, Manuel Macia, Tomas Garcia-Caballero, Francisco J Vizoso, Roman Perez-Fernandez
No abstract text is available yet for this article.
March 28, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28351375/erratum-to-honokiol-activates-amp-activated-protein-kinase-in-breast-cancer-cells-via-lkb1-dependent-pathway-and-inhibits-breast-carcinogenesis
#14
Arumugam Nagalingam, Jack L Arbiser, Michael Y Bonner, Neeraj K Saxena, Dipali Sharma
No abstract text is available yet for this article.
March 28, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28351372/erratum-to-cyclin-d1-cooperates-with-p21-to-regulate-tgf%C3%AE-mediated-breast-cancer-cell-migration-and-tumor-local-invasion
#15
Meiou Dai, Amal A Al-Odaini, Nadège Fils-Aimé, Manuel A Villatoro, Jimin Guo, Ani Arakelian, Shafaat A Rabbani, Suhad Ali, Jean Jacques Lebrun
No abstract text is available yet for this article.
March 28, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28351370/erratum-to-loss-of-plakoglobin-promotes-cell-cell-contact-increased-invasion-and-breast-cancer-cell-dissemination-in-vivo
#16
Ingunn Holen, Jacob Whitworth, Faith Nutter, Alyson Evans, Hannah K Brown, Diane V Lefley, Ivana Barbaric, Mark Jones, Penelope D Ottewell
No abstract text is available yet for this article.
March 28, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28340626/decision-making-for-breast-cancer-prevention-among-women-at-elevated-risk
#17
REVIEW
Tasleem J Padamsee, Celia E Wills, Lisa D Yee, Electra D Paskett
Several medical management approaches have been shown to be effective in preventing breast cancer and detecting it early among women at elevated risk: 1) prophylactic mastectomy; 2) prophylactic oophorectomy; 3) chemoprevention; and 4) enhanced screening routines. To varying extents, however, these approaches are substantially underused relative to clinical practice recommendations. This article reviews the existing research on the uptake of these prevention approaches, the characteristics of women who are likely to use various methods, and the decision-making processes that underlie the differing choices of women...
March 24, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28340615/glucocorticoids-induce-production-of-reactive-oxygen-species-reactive-nitrogen-species-and-dna-damage-through-an-inos-mediated-pathway-in-breast-cancer
#18
Renée L Flaherty, Matthew Owen, Aidan Fagan-Murphy, Haya Intabli, David Healy, Anika Patel, Marcus C Allen, Bhavik A Patel, Melanie S Flint
BACKGROUND: Psychological stress increases the circulating levels of the stress hormones cortisol and norepinephrine (NE). Chronic exposure to elevated stress hormones has been linked to a reduced response to chemotherapy through induction of DNA damage. We hypothesize that stress hormone signalling may induce DNA damage through the production of reactive oxygen species (ROS)/reactive nitrogen species (RNS) and interference in DNA repair processes, promoting tumourigenesis. METHODS: Breast cancer cell lines were incubated with physiological levels of cortisol and NE in the presence and absence of receptor antagonists and inducible nitric oxide synthase (iNOS) inhibitors and DNA damage measured using phosphorylated γ-H2AX...
March 24, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28330493/loss-of-mmp-8-in-ductal-carcinoma-in-situ-dcis-associated-myoepithelial-cells-contributes-to-tumour-promotion-through-altered-adhesive-and-proteolytic-function
#19
Muge Sarper, Michael D Allen, Jenny Gomm, Linda Haywood, Julie Decock, Sally Thirkettle, Ahsen Ustaoglu, Shah-Jalal Sarker, John Marshall, Dylan R Edwards, J Louise Jones
BACKGROUND: Normal myoepithelial cells (MECs) play an important tumour-suppressor role in the breast but display an altered phenotype in ductal carcinoma in situ (DCIS), gaining tumour-promoter functions. Matrix metalloproteinase-8 (MMP-8) is expressed by normal MECs but is lost in DCIS. This study investigated the function of MMP-8 in MECs and the impact of its loss in DCIS. METHODS: Primary normal and DCIS-associated MECs, and normal (N-1089) and DCIS-modified myoepithelial (β6-1089) cell lines, were used to assess MMP-8 expression and function...
March 23, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28327201/detecting-gene-signature-activation-in-breast-cancer-in-an-absolute-single-patient-manner
#20
E R Paquet, R Lesurf, A Tofigh, V Dumeaux, M T Hallett
BACKGROUND: The ability to reliably identify the state (activated, repressed, or latent) of any molecular process in the tumor of a patient from an individual whole-genome gene expression profile obtained from microarray or RNA sequencing (RNA-seq) promises important clinical utility. Unfortunately, all previous bioinformatics tools are only applicable in large and diverse panels of patients, or are limited to a single specific pathway/process (e.g. proliferation). METHODS: Using a panel of 4510 whole-genome gene expression profiles from 10 different studies we built and selected models predicting the activation status of a compendium of 1733 different biological processes...
March 21, 2017: Breast Cancer Research: BCR
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