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Breast Cancer Research: BCR

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https://www.readbyqxmd.com/read/30005601/pyruvate-carboxylase-supports-the-pulmonary-tropism-of-metastatic-breast-cancer
#1
Aparna Shinde, Tomasz Wilmanski, Hao Chen, Dorothy Teegarden, Michael K Wendt
BACKGROUND: Overcoming systemic dormancy and initiating secondary tumor grow under unique microenvironmental conditions is a major rate-limiting step in metastatic progression. Disseminated tumor cells encounter major changes in nutrient supplies and oxidative stresses compared to the primary tumor and must demonstrate significant metabolic plasticity to adapt to specific metastatic sites. Recent studies suggest that differential utilization of pyruvate sits as a critical node in determining the organotropism of metastatic breast cancer...
July 13, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29996935/etv4-transcription-factor-and-mmp13-metalloprotease-are-interplaying-actors-of-breast-tumorigenesis
#2
Mandy Dumortier, Franck Ladam, Isabelle Damour, Sophie Vacher, Ivan Bièche, Nathalie Marchand, Yvan de Launoit, David Tulasne, Anne Chotteau-Lelièvre
BACKGROUND: The ETS transcription factor ETV4 is involved in the main steps of organogenesis and is also a significant mediator of tumorigenesis and metastasis, such as in breast cancer. Indeed, ETV4 is overexpressed in breast tumors and is associated with distant metastasis and poor prognosis. However, the cellular and molecular events regulated by this factor are still misunderstood. In mammary epithelial cells, ETV4 controls the expression of many genes, MMP13 among them. The aim of this study was to understand the function of MMP13 during ETV4-driven tumorigenesis...
July 11, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29996906/estrogen-promotes-estrogen-receptor-negative-brca1-deficient-tumor-initiation-and-progression
#3
Chuying Wang, Feng Bai, Li-Han Zhang, Alexandria Scott, Enxiao Li, Xin-Hai Pei
BACKGROUND: Estrogen promotes breast cancer development and progression mainly through estrogen receptor (ER). However, blockage of estrogen production or action prevents development of and suppresses progression of ER-negative breast cancers. How estrogen promotes ER-negative breast cancer development and progression is poorly understood. We previously discovered that deletion of cell cycle inhibitors p16Ink4a (p16) or p18Ink4c (p18) is required for development of Brca1-deficient basal-like mammary tumors, and that mice lacking p18 develop luminal-type mammary tumors...
July 11, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29996899/circulating-micrornas-in-the-early-prediction-of-disease-recurrence-in-primary-breast-cancer
#4
Chara Papadaki, Michalis Stratigos, Georgios Markakis, Maria Spiliotaki, Georgios Mastrostamatis, Christoforos Nikolaou, Dimitrios Mavroudis, Sofia Agelaki
BACKGROUND: In primary breast cancer metastases frequently arise from a state of dormancy that may persist for extended periods of time. We investigated the efficacy of plasma micro-RNA (miR)-21, miR-23b, miR-190, miR-200b and miR-200c, related to dormancy and metastasis, to predict the outcome of patients with early breast cancer. METHODS: miRNAs were evaluated by RT-qPCR in plasma obtained before adjuvant chemotherapy. miRNA expression, classified as high or low according to median values, correlated with relapse and survival...
July 11, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29996894/vitamin-d-dna-methylation-and-breast-cancer
#5
Katie M O'Brien, Dale P Sandler, Zongli Xu, H Karimi Kinyamu, Jack A Taylor, Clarice R Weinberg
BACKGROUND: Vitamin D has anticarcinogenic and immune-related properties and may protect against some diseases, including breast cancer. Vitamin D affects gene transcription and may influence DNA methylation. METHODS: We studied the relationships between serum vitamin D, DNA methylation, and breast cancer using a case-cohort sample (1070 cases, 1277 in subcohort) of non-Hispanic white women. For our primary analysis, we used robust linear regression to examine the association between serum 25-hydroxyvitamin D (25(OH)D) and methylation within a random sample of the cohort ("subcohort")...
July 11, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29996881/the-association-of-genomic-lesions-and-pd-1-pd-l1-expression-in-resected-triple-negative-breast-cancers
#6
Michael T Barrett, Elizabeth Lenkiewicz, Smriti Malasi, Anamika Basu, Jennifer Holmes Yearley, Lakshmanan Annamalai, Ann E McCullough, Heidi E Kosiorek, Pooja Narang, Melissa A Wilson Sayres, Meixuan Chen, Karen S Anderson, Barbara A Pockaj
BACKGROUND: Elevated PD-L1 expression on tumor cells, a context associated with an adaptive immune response, has been linked to the total burden of copy number variants (CNVs) in aneuploid tumors, to microsatellite instability (MSI), and to specific genomic driver lesions, including loss of PTEN, MYC amplification, and activating mutations in driver oncogenes such as KRAS and PIK3CA. Triple-negative breast cancers (TNBCs) typically have high levels of CNVs and diverse driver lesions in their genomes...
July 11, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29996866/intrinsic-molecular-subtypes-of-breast-cancers-categorized-as-her2-positive-using-an-alternative-chromosome-17-probe-assay
#7
Neelam V Desai, Vanda Torous, Joel Parker, James T Auman, Gary B Rosson, Cassandra Cruz, Charles M Perou, Stuart J Schnitt, Nadine Tung
The 2013 update of the American Society of Clinical Oncology-College of American Pathologists (ASCO-CAP) human epidermal growth factor receptor 2 (HER2) testing guidelines recommend using an alternative chromosome 17 probe assay to resolve HER2 results determined to be equivocal by immunohistochemistry (IHC) or fluorescence in-situ hybridization (FISH). However, it is unclear if cases considered HER2-positive (HER2+ ) by the alternative probe method are similar to those classified as HER2+ by traditional IHC and FISH criteria and benefit the same from HER2-targeted therapies...
July 11, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29986750/intra-operative-spectroscopic-assessment-of-surgical-margins-during-breast-conserving-surgery
#8
Dustin W Shipp, Emad A Rakha, Alexey A Koloydenko, R Douglas Macmillan, Ian O Ellis, Ioan Notingher
BACKGROUND: In over 20% of breast conserving operations, postoperative pathological assessment of the excised tissue reveals positive margins, requiring additional surgery. Current techniques for intra-operative assessment of tumor margins are insufficient in accuracy or resolution to reliably detect small tumors. There is a distinct need for a fast technique to accurately identify tumors smaller than 1 mm2 in large tissue surfaces within 30 min. METHODS: Multi-modal spectral histopathology (MSH), a multimodal imaging technique combining tissue auto-fluorescence and Raman spectroscopy was used to detect microscopic residual tumor at the surface of the excised breast tissue...
July 9, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29986739/correction-to-the-mtor-inhibitor-rapamycin-down-regulates-the-expression-of-the-ubiquitin-ligase-subunit-skp2-in-breast-cancer-cells
#9
Ma'anit Shapira, Eli Kakiashvili, Tzur Rosenberg, Dan D Hershko
After the publication of this work [1], an error was noticed in Fig. 2b, Fig. 3a and Fig. 5b. The Skp1 loading control was accidentally duplicated. We apologize for this error, which did not affect any of the interpretations or conclusions of the article.
July 9, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29976237/evaluation-of-%C3%AE-tubulin-detyrosinated-%C3%AE-tubulin-and-vimentin-in-ctcs-identification-of-the-interaction-between-ctcs-and-blood-cells-through-cytoskeletal-elements
#10
G Kallergi, D Aggouraki, N Zacharopoulou, C Stournaras, V Georgoulias, S S Martin
BACKGROUND: Circulating tumor cells (CTCs) are the major players in the metastatic process. A potential mechanism of cell migration and invasion is the formation of microtentacles in tumor cells. These structures are supported by α-tubulin (TUB), detyrosinated α-tubulin (GLU), and vimentin (VIM). In the current study, we evaluated the expression of those cytoskeletal proteins in CTCs. METHODS: Forty patients with breast cancer (BC) (16 early and 24 metastatic) were enrolled in the study...
July 5, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29976229/syndecan-1-induction-in-lung-microenvironment-supports-the-establishment-of-breast-tumor-metastases
#11
Colleen Chute, Xinhai Yang, Kristy Meyer, Ning Yang, Keelin O'Neil, Ildiko Kasza, Kevin Eliceiri, Caroline Alexander, Andreas Friedl
BACKGROUND: Syndecan-1 (Sdc1), a cell surface heparan sulfate proteoglycan normally expressed primarily by epithelia and plasma cells, is aberrantly induced in stromal fibroblasts of breast carcinomas. Stromal fibroblast-derived Sdc1 participates in paracrine growth stimulation of breast carcinoma cells and orchestrates stromal extracellular matrix fiber alignment, thereby creating a migration and invasion-permissive microenvironment. Here, we specifically tested the role of stromal Sdc1 in metastasis...
July 5, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29973242/identification-and-validation-of-single-sample-breast-cancer-radiosensitivity-gene-expression-predictors
#12
Martin Sjöström, Johan Staaf, Patrik Edén, Fredrik Wärnberg, Jonas Bergh, Per Malmström, Mårten Fernö, Emma Niméus, Irma Fredriksson
BACKGROUND: Adjuvant radiotherapy is the standard of care after breast-conserving surgery for primary breast cancer, despite a majority of patients being over- or under-treated. In contrast to adjuvant endocrine therapy and chemotherapy, no diagnostic tests are in clinical use that can stratify patients for adjuvant radiotherapy. This study presents the development and validation of a targeted gene expression assay to predict the risk of ipsilateral breast tumor recurrence and response to adjuvant radiotherapy after breast-conserving surgery in primary breast cancer...
July 4, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29973218/glucocorticoids-promote-transition-of-ductal-carcinoma-in-situ-to-invasive-ductal-carcinoma-by-inducing-myoepithelial-cell-apoptosis
#13
Arantzazu Zubeldia-Plazaola, Leire Recalde-Percaz, Núria Moragas, Mireia Alcaraz, Xieng Chen, Mario Mancino, Patricia Fernández-Nogueira, Miquel Prats de Puig, Flavia Guzman, Aleix Noguera-Castells, Anna López-Plana, Estel Enreig, Neus Carbó, Vanessa Almendro, Pedro Gascón, Paloma Bragado, Gemma Fuster
BACKGROUND: The microenvironment and stress factors like glucocorticoids have a strong influence on breast cancer progression but their role in the first stages of breast cancer and, particularly, in myoepithelial cell regulation remains unclear. Consequently, we investigated the role of glucocorticoids in ductal carcinoma in situ (DCIS) in breast cancer, focusing specially on myoepithelial cells. METHODS: To clarify the role of glucocorticoids at breast cancer onset, we evaluated the effects of cortisol and corticosterone on epithelial and myoepithelial cells using 2D and 3D in vitro and in vivo approaches and human samples...
July 4, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29966525/correction-to-identification-of-the-functional-role-of-peroxiredoxin-6-in-the-progression-of-breast-cancer
#14
Xin-Zhong Chang, Da-Qiang Li, Yi-Feng Hou, Jiong Wu, Jin-Song Lu, Gen-Hong Di, Wei Jin, Zhou-Luo Ou, Zhen-Zhou Shen, Zhi-Ming Shao
After the publication of this work [1] an error in Fig. 1c was brought to our attention: the Western blots for PRDX6 and β-actin were similar to those shown in lanes 5-6 of Fig. 4g. To verify these findings, we have repeated this experiment and the results are shown in a new Fig. 1c below. The repeated experimental results are consistent with the previously reported findings in the original study [1] and the functional role for PRDX6 in malignant progression of human cancer including breast cancer has been widely documented and recognized in numerous other studies [2]...
July 2, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29929548/immune-characterization-of-breast-cancer-metastases-prognostic-implications
#15
Maria Vittoria Dieci, Vassilena Tsvetkova, Enrico Orvieto, Federico Piacentini, Guido Ficarra, Gaia Griguolo, Federica Miglietta, Tommaso Giarratano, Claudia Omarini, Serena Bonaguro, Rocco Cappellesso, Camillo Aliberti, Grazia Vernaci, Carlo Alberto Giorgi, Giovanni Faggioni, Giulia Tasca, Pierfranco Conte, Valentina Guarneri
BACKGROUND: Tumor-infiltrating lymphocytes (TILs) evaluated in primary breast cancer (BC) convey prognostic information. Limited data in the metastatic setting are available. METHODS: Secondary lesions from 94 BC patients, 43 triple-negative (TN) and 51 HER2-positive, were evaluated for TILs and expression of CD8, FOXP3, and PD-L1 by immunohistochemistry. RESULTS: TILs levels on metastasis were generally low (median 5%) and did not differ between TN and HER2+ tumors...
June 22, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29925428/correction-to-nongenomic-oestrogen-signalling-in-oestrogen-receptor-negative-breast-cancer-cells-a-role-for-the-angiotensin-ii-receptor-at1
#16
Kheng Tian Lim, Niamh Cosgrave, Arnold David Hill, Leonie S Young
After the publication of this work [1] errors were noticed in the total protein loading controls for Figs. 1C, 2B, 3B and 4B.
June 20, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29921323/can-diffusion-weighted-imaging-predict-tumor-grade-and-expression-of-ki-67-in-breast-cancer-a-multicenter-analysis
#17
Alexey Surov, Paola Clauser, Yun-Woo Chang, Lihua Li, Laura Martincich, Savannah C Partridge, Jin You Kim, Hans Jonas Meyer, Andreas Wienke
BACKGROUND: Numerous studies have analyzed associations between apparent diffusion coefficient (ADC) and histopathological features such as Ki-67 proliferation index in breast cancer (BC), with mixed results. The purpose of this study was to perform a multicenter analysis to determine relationships between ADC and expression of Ki-67 and tumor grade in BC. METHODS: For this study, data from six centers were acquired. The sample comprises 870 patients (all female; mean age, 52...
June 19, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29921315/expression-of-id4-protein-in-breast-cancer-cells-induces-reprogramming-of-tumour-associated-macrophages
#18
Sara Donzelli, Elisa Milano, Magdalena Pruszko, Andrea Sacconi, Silvia Masciarelli, Ilaria Iosue, Elisa Melucci, Enzo Gallo, Irene Terrenato, Marcella Mottolese, Maciej Zylicz, Alicja Zylicz, Francesco Fazi, Giovanni Blandino, Giulia Fontemaggi
BACKGROUND: As crucial regulators of the immune response against pathogens, macrophages have been extensively shown also to be important players in several diseases, including cancer. Specifically, breast cancer macrophages tightly control the angiogenic switch and progression to malignancy. ID4, a member of the ID (inhibitors of differentiation) family of proteins, is associated with a stem-like phenotype and poor prognosis in basal-like breast cancer. Moreover, ID4 favours angiogenesis by enhancing the expression of pro-angiogenic cytokines interleukin-8, CXCL1 and vascular endothelial growth factor...
June 19, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29921289/snai2-upregulation-is-associated-with-an-aggressive-phenotype-in-fulvestrant-resistant-breast-cancer-cells-and-is-an-indicator-of-poor-response-to-endocrine-therapy-in-estrogen-receptor-positive-metastatic-breast-cancer
#19
Carla L Alves, Daniel Elias, Maria B Lyng, Martin Bak, Henrik J Ditzel
BACKGROUND: Endocrine resistance in estrogen receptor-positive (ER+) breast cancer is a major clinical problem and is associated with accelerated cancer cell growth, increased motility and acquisition of mesenchymal characteristics. However, the specific molecules and pathways involved in these altered features remain to be detailed, and may be promising therapeutic targets to overcome endocrine resistance. METHODS: In the present study, we evaluated altered expression of epithelial-mesenchymal transition (EMT) regulators in ER+ breast cancer cell models of tamoxifen or fulvestrant resistance, by gene expression profiling...
June 19, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29903038/correction-to-buthionine-sulfoximine-sensitizes-antihormone-resistant-human-breast-cancer-cells-to-estrogen-induced-apoptosis
#20
Joan S Lewis-Wambi, Helen R Kim, Chris Wambi, Roshani Patel, Jennifer R Pyle, Andres J Klein-Szanto, V Craig Jordan
After the publication of this work [1] an error was noticed in Fig. 3a and Fig. 5a.
June 14, 2018: Breast Cancer Research: BCR
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