Xue Zhang, JingCheng Wu, Yuanyuan Luo, Yilin Wang, Yujie Wu, Xiaobin Xu, Yufang Zhang, Ruiying Kong, Ying Chi, Yisheng Sun, Shuqing Chen, Qiaojun He, Feng Zhu, Zhan Zhou
Coronaviruses have threatened humans repeatedly, especially COVID-19 caused by SARS-CoV-2, which has posed a substantial threat to global public health. SARS-CoV-2 continuously evolves through random mutation, resulting in a significant decrease in the efficacy of existing vaccines and neutralizing antibody drugs. It is critical to assess immune escape caused by viral mutations and develop broad-spectrum vaccines and neutralizing antibodies targeting conserved epitopes. Thus, we constructed CovEpiAb, a comprehensive database and analysis resource of human coronavirus (HCoVs) immune epitopes and antibodies...
March 27, 2024: Briefings in Bioinformatics