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Progress in Transplantation

Juraj Miklušica, Ivana Dedinská, Blažej Palkoci, Alexander Sendrey, Mariana Lajčiaková, Martin Vojtko, Denisa Osinová, L'udovít Laca
Delayed graft function continues to pose a significant challenge to clinicians in the context of kidney transplantation. The objective of this retrospective, 5-year analysis is to identify the parameters of beating heart donors and those of recipients that affect the delayed development of graft function. The monitored group was composed of 152 beating heart donors and 179 recipients. Delayed graft function was identified in 32 (17%) patients. The predictor for development of delayed graft function was the body mass index of the donor (odds ratio: 1...
January 1, 2018: Progress in Transplantation
Antonio Ríos, A López-Navas, A López-López, F J Gómez, J Iriarte, R Herruzo, G Blanco, F J Llorca, A Asunsolo, P Sánchez, P R Gutiérrez, A Fernández, M T de Jesús, L Martínez Alarcón, M Del Olivo, L Fuentes, J R Hernández, J Virseda, J Yelamos, J A Bondía, A M Hernández, M A Ayala, P Ramírez, P Parrilla
OBJECTIVE: To analyze the level of understanding of the brain death concept among medical students in universities in Spain. METHODS: This cross-sectional sociological, interdisciplinary, and multicenter study was performed on 9598 medical students in Spain. The sample was stratified by geographical area and academic year. A previously validated self-reported measure of brain death knowledge (questionnaire Proyecto Colaborativo Internacional Donante sobre la Donación y Transplante de Organos) was completed anonymously by students...
January 1, 2018: Progress in Transplantation
Lisa Stoessel, Katharina Schieber, Sabine Jank, Sandra Reber, Franziska Grundmann, Christine Lueker, Frank Vitinius, Georgios Paslakis, Kai-Uwe Eckardt, Yesim Erim
INTRODUCTION: Kidney transplantation is beneficial in improving cognitive abilities in patients with chronic kidney disease; however, there is still uncertainty concerning which cognitive domains benefit and to what extent. AIM: In the present study, cognitive functioning of renal transplant recipients was compared to normative data. Sociodemographic and clinical parameters that were associated with low cognitive performance were identified. DESIGN: A total of 109 renal transplant recipients (63% men) participated in the study, with a mean age of 51...
December 2017: Progress in Transplantation
Teresa Poon, Christina M Guerra
CONTEXT: Neutropenia is associated with a high risk of serious infections in kidney transplant recipients. There are no sufficient studies of using granulocyte colony-stimulating factors, such as filgrastim, in renal transplant recipients to establish a clear, specified role of this off-label indication. Using filgrastim in these patients may increase the risk of rejection by overstimulating the immune system. OBJECTIVE: To evaluate the use of filgrastim in adult kidney transplant recipients presenting with neutropenia...
December 2017: Progress in Transplantation
Andreas Ihrig, Imad Maatouk, Susanne Fink, Sascha Pahernik, Caner Süsal, Johannes Huber, Markus Hohenfellner, Martin Zeier, Carsten Grüllich
Patients with cancer who require a kidney transplant often face a prolonged time on the waiting list to ensure a sufficient relapse-free time. Patients and relatives were invited to the patient assessment service where they get an individualized risk assessment and a recommendation for transplantation and waiting period directly from an expert panel. We investigated in 31 patients who filled out questionnaires concerning depression, anxiety, distress, and quality of life and were interviewed for their satisfaction, experiences, and circumstances of the counseling...
December 2017: Progress in Transplantation
Francis L Weng, John D Peipert, Bart K Holland, Diane R Brown, Amy D Waterman
INTRODUCTION: Maximizing education about living donor kidney transplant (LDKT) during the in-person evaluation at the transplant center may increase the numbers of kidney patients pursuing LDKT. Research Questions and Design: To test the effectiveness of a 1-time LDKT educational intervention, we performed a cluster-randomized trial among 499 patients who presented for evaluation of kidney transplant. We compared usual care education (n = 250) versus intensive LDKT education (n = 249), which was implemented only on the evaluation day and consisted of viewing a 25-minute video of information and stories about LDKT and discussion of LDKT possibilities with an educator...
December 2017: Progress in Transplantation
A L Croci Chiocchini, C Sportoletti, G Comai, S Brocchi, I Capelli, O Baraldi, P Bruno, F Conti, C Serra, M Meola, M Zompatori, G La Manna
INTRODUCTION: Renal allograft biopsy is the gold standard for the detection of histological lesions of chronic allograft dysfunction. The identification of a noninvasive routine test would be desirable. Elastosonography is used to assess tissue stiffness according to viscosity, and no data are available on the use of point quantification shear-wave elastography (ElastPQ) for the evaluation of renal chronic lesions. RESEARCH QUESTION: To evaluate the feasibility of ElastPQ to assess cortical allograft stiffness and to determine the correlation of clinical, biological, and pathological factors with the diagnostic accuracy of kidney stiffness values in patients with histological lesions...
December 2017: Progress in Transplantation
Caitlin Loughery, Nanhua Zhang, Ken Resnicow, Remonia Chapman, John C Magee, Ann M Andrews
INTRODUCTION: Health education programs can positively impact organ donor designation among African Americans, a disproportionately represented group on the transplant waiting list. Alumni chapters of historically African American sororities and fraternities are a novel setting for organ donation education and research. RESEARCH QUESTIONS: This study tested the effectiveness of a lay health advisor model to increase donor designation registrations on the Michigan Organ Donor Registry among members of Midwest alumni chapters...
December 2017: Progress in Transplantation
Raffaele Girlanda, Chirag Desai, Cal Matsumoto, Thomas Fishbein
The rich component of lymphatics makes the intestine prone to leaks of lymph after transplantation secondary to their transection during procurement. We describe our technique for isolation and ligation of the small lymphatics at the root of the mesentery during the procurement of the small intestine and report our experience with the management of lymphatic leaks posttransplant.
December 2017: Progress in Transplantation
Laust Dupont, Ivar Anders Eide, Anders Hartmann, Jeppe Hagstrup Christensen, Anders Åsberg, Trond Jenssen, Henrik Krarup, My Svensson
BACKGROUND: Cardiovascular disease is the leading cause of death in renal transplant recipients. An association between haptoglobin genotype 2-2 and cardiovascular disease has been found in patients with diabetes mellitus and liver transplant recipients. To date, the role of haptoglobin genotype after renal transplantation has not been studied. METHODS: In this single-center retrospective cohort study of 1975 adult Norwegian transplant recipients, who underwent transplantation between 1999 and 2011, we estimated the risk of all-cause and cardiovascular mortality and overall and death-censored graft loss for patients with haptoglobin genotype 2-2 compared to genotype 2-1 or 1-1, after adjustment for confounders and competing risks...
December 2017: Progress in Transplantation
Jessica L Chandler, Luke R Sox, Jenna R Gunsolley, Frank A Treiber, John W McGillicuddy
No abstract text is available yet for this article.
December 2017: Progress in Transplantation
Rebecca P Winsett
No abstract text is available yet for this article.
December 2017: Progress in Transplantation
Yasemin Benderli Cihan
For frequently seen noncomplex cancer presentation, it is important to use rapid, effective, and inexpensive radiotherapy methods. However, for the complex cancer, these sophisticated radiotherapy techniques can decrease morbidity and mortality in our transplant patients and should be considered.
December 2017: Progress in Transplantation
Gaby F van Ek, Esmée M Krouwel, Els van der Veen, Melianthe P J Nicolai, Jan Ringers, Brenda L Den Oudsten, Hein Putter, Rob C M Pelger, Henk W Elzevier
INTRODUCTION: Sexual dysfunction (SD) is a common problem in chronic kidney disease (CKD) and endures in 50% of patients after kidney transplantation (KTx), diminishing patients' expectations of life after KTx. Unfortunately, SD is often ignored by renal care providers. Research questions as part of a research project among all renal care providers, transplant surgeons' perspectives were obtained on sexual health care for KTx recipients, including their opinion on who should be accountable for this care...
December 2017: Progress in Transplantation
Julie Elizabeth Potter, Jonathan J Gatward, Michelle A Kelly, Leigh McKay, Ellie McCann, Rosalind M Elliott, Lin Perry
INTRODUCTION: The approach, communication skills, and confidence of clinicians responsible for raising deceased organ donation may influence families' donation decisions. The aim of this study was to increase the preparedness and confidence of intensive care clinicians allocated to work in a "designated requester" role. DESIGN: We conducted a posttest evaluation of an innovative simulation-based training program. Simulation-based training enabled clinicians to rehearse the "balanced approach" to family donation conversations (FDCs) in the designated requester role...
December 2017: Progress in Transplantation
Anne L Dalle Ave, David M Shaw, Bernice Elger
Faced with similar issues of organ scarcity to its neighbors, Switzerland has developed donation after circulatory determination of death (DCDD) as a way to expand the organ pool since 1985. Here, we analyze the history, practical considerations, and ethical issues relating to the Swiss donation after circulatory death programs. In Switzerland, determination of death for DCDD requires a stand-off period of 10 minutes. This time between cardiac arrest and the declaration of death is mandated in the guidelines of the Swiss Academy of Medical Sciences...
September 2017: Progress in Transplantation
Mokshya Sharma, Aijaz Ahmed, Robert J Wong
INTRODUCTION: The age of liver transplantation recipients in the United States is steadily increasing. However, the impact of age on liver transplant outcomes has demonstrated contradictory results. RESEARCH QUESTIONS: We aim to evaluate the impact of age on survival following liver transplantation among US adults. DESIGN: Using data from the United Network for Organ Sharing registry, we retrospectively evaluated all adults undergoing liver transplantation from 2002 to 2012 stratified by age (aged 70 years and older vs aged <70 years), presence of hepatocellular carcinoma, and hepatitis C virus status...
September 2017: Progress in Transplantation
Thomas Hugh Feeley, Ashley E Anker, Melanie Evans, Tobias Reynolds-Tylus
CONTEXT: Examination of efficacy of motor vehicle representative educational training and dissemination of promotional materials as a means to promote organ donation enrollments in New York State. OBJECTIVE: To increase the number of New York State residents who consent to donation through the department of motor vehicle transactions during project period. SETTING: County-run motor vehicle offices across New York State. PARTICIPANTS: Customers who present to New York Department of Motor Vehicle offices and the representative who work at designated bureaus...
September 2017: Progress in Transplantation
Timmy Li, M Katherine Dokus, Kristin N Kelly, Nene Ugoeke, James R Rogers, George Asham, Venkatesh Abhishek Sharma, Dominic J Cirillo, Mary K Robinson, Erika K Venniro, Jeremy G Taylor, Mark S Orloff, Scott McIntosh, Randeep Kashyap
INTRODUCTION: Understanding living organ donors' experience with donation and challenges faced during the process is necessary to guide the development of effective strategies to maximize donor benefit and increase the number of living donors. METHODS: An anonymous self-administered survey, specifically designed for this population based on key informant interviews, was mailed to 426 individuals who donated a kidney or liver at our institution. Quantitative and qualitative methods including open and axial coding were used to analyze donor responses...
September 2017: Progress in Transplantation
Sarah Elizabeth Golding, Mark Cropley
BACKGROUND: The demand for organ donation is increasing worldwide. One possible way of increasing the pool of potential posthumous donors is to encourage more members of the general public to join an organ donor registry. OBJECTIVE: A systematic review was conducted to investigate the effectiveness of psychological interventions designed to increase the number of individuals in the community who register as organ donors. METHODS: PsycINFO and PubMed databases were searched...
September 2017: Progress in Transplantation
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