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Progress in Transplantation

Maria Teresa Tomás, Xavier Melo, Élia Mateus, Mafalda Gonçalves, Eduardo Barroso, Helena Santa-Clara
BACKGROUND: Supervised (SE) and home-based exercise (HBE) training regimes are effective on reconditioning patients with familial amyloidotic polyneuropathy (FAP) after liver transplantation, but research of the long-term retention of the benefits attained in patients with FAP has not yet been conducted. PURPOSE: In this 5-year follow-up study, we aimed to determine whether the exercise training gains in body composition, physical activity, and function promoted by a 24-week SE or HBE training regimes are retained in patients with FAP who resume normal activity...
September 27, 2018: Progress in Transplantation
G Alden Holmes, Joseph Soo, Sharon E Jacob
The improved survival of liver transplant recipients (LTRs) has been accompanied by a concomitant rise in long-term liver transplantation complications, including skin cancer. A recent study found that the prevalence of skin cancer among LTRs is 13.5%, a rate equivalent to that observed among kidney transplant recipients. Given the morbidity associated with skin cancer in LTRs, an individualized, multidisciplinary approach to skin cancer prevention that incorporates patient education, encourages consistent use of primary prevention methods, and ensures routine dermatologic screening should be universally adopted in this population...
September 24, 2018: Progress in Transplantation
Tara O'Brien, Cynthia L Russell, Alai Tan, Mallory Washington, Donna Hathaway
INTRODUCTION: Rapidly growing use of mobile technology provides a platform for self-management of care support for those with chronic conditions. Few studies have explored the characteristics or access patterns of kidney transplant recipients who use mHealth applications (apps) for self-management of care. RESEARCH QUESTIONS: The primary aim of this study was to describe demographics, use, barriers, and perceptions of mobile apps for self-management of care among adult kidney transplants recipients...
September 24, 2018: Progress in Transplantation
Amanda J Chaney, Michael G Heckman
INTRODUCTION: Nutritional interventions improve patient outcomes and reduce mortality in patients with cirrhosis by reducing infection risk, ascites, length of stay in hospital and intensive care unit, and mortality. Follow-up phone calls have been found to be useful in improving patient adherence to therapy. PROBLEM: The purpose of this quality improvement project was to determine whether supplemental nutrition education would improve nutrition and outcomes among patients with cirrhosis who are undergoing a liver transplant evaluation...
September 24, 2018: Progress in Transplantation
Miguel Moyses Neto, Roberto Silva Costa, Gustavo Frezza, Tania M Garcia, Maria Estela Papini Nardin, Elen Almeida Romao
No abstract text is available yet for this article.
September 24, 2018: Progress in Transplantation
Baran Balcan, Umit Ozcelik, Aylin Ozsancakli Ugurlu, Mehtap Aydin, Serdar Nalcaci, Feza Yarbug Karakayali
INTRODUCTION: Renal transplantation is the most effective and preferred definite treatment option in patients with end-stage renal disease. Due to long-term immunesuppressive treatment, renal transplant recipients become vulnerable to opportunistic infections, especially to fungal infections. METHOD: This was a single-center, retrospective observational study of 438 patients who underwent renal transplantation between 2010 and 2016. RESULTS: Thirty-eight renal transplant recipients who had lower respiratory tract infection with median age of 41...
September 20, 2018: Progress in Transplantation
Helene Vilme, Clemontina A Davenport, Jane Pendergast, L Ebony Boulware
BACKGROUND: Due to marginal efforts to increase living donor kidney transplantation, it is unclear whether interventions to improve African Americans' interest and pursuit of living donation should be tailored to address patients' exposure to or familiarity with dialysis or transplant settings. DESIGN, SETTING, AND PARTICIPANTS: We conducted a cross-sectional secondary analysis of baseline data from 3 separate randomized clinical trials among African Americans with varying degrees of experience with dialysis or transplantation (predialysis, on dialysis but not on transplant list, and on transplant wait-list) settings...
September 19, 2018: Progress in Transplantation
Hamza Hassan Khan, Adarsh Vijay, Matthew Cooper, Seyed Reza Ghasemian
No abstract text is available yet for this article.
September 17, 2018: Progress in Transplantation
David Snipelisky, Justin Shipman, Nicole Olson, Patricia Pellikka, Bashar Aqel, Robert McCully, Kymberly Watt
INTRODUCTION: Dobutamine stress echocardiography (DSE) is frequently used to screen for obstructive coronary artery disease in the pre-liver transplant evaluation. Although atropine is a commonly used adjunctive medication, no study has evaluated its side effect profile in patients with end-stage liver disease (ESLD). RESEARCH QUESTION: What is the safety of atropine in candidates undergoing pre-liver transplant evaluation when atropine is used in stress testing? DESIGN: This multicenter, prospective study enrolled patients over a 6-month period undergoing pre-liver transplant evaluation...
September 16, 2018: Progress in Transplantation
Brett G Sampson, Steven R Wilson, Mark E Finnis, Alison M Hodak, Philippa N Jones, Stephanie L O'Connor, Marianne J Chapman
BACKGROUND: The Australian and New Zealand Intensive Care Society and the Australasian Transplant Coordinators Association provide recommendations on the physiological management of brain-dead donors. PROBLEM STATEMENT: How often physiological targets are prescribed for brain-dead donors in Australian intensive care units (ICUs), and how well these compare to recommended targets is unknown. It is also unknown how often recommended targets are achieved, irrespective of prescribed targets...
September 16, 2018: Progress in Transplantation
Aimee J Sarti, Stephanie Sutherland, Andrew Healey, Sonny Dhanani, Angele Landriault, Frances Fothergill-Bourbonnais, Michael Hartwick, Janice Beitel, Simon Oczkowski, Pierre Cardinal
BACKGROUND: Organ donation research has centered on improving donation rates rather than focusing on the experience and impact on substitute decision makers. The purpose of this study was to document donor and nondonor family experiences, as well as lasting impacts of donation. METHODS: We used a qualitative exploratory design. Semistructured interviews of 27 next-of-kin decision makers were conducted, transcribed verbatim, and entered into qualitative software...
September 16, 2018: Progress in Transplantation
Linda Ohler
No abstract text is available yet for this article.
September 16, 2018: Progress in Transplantation
Razan Alsheikh, Osamah M Alfayez, Majed S Al Yami
Solid organ transplant patients are at risk of developing atrial fibrillation and venous thromboembolism. Direct oral anticoagulants are considered an attractive option for anticoagulation in patients due to their convenience; however, strong evidence of their use in transplantation is lacking. We conducted a search using Pubmed, Embase, and Scopus databases, in addition to International Society of Heart and Lung transplantation and American Transplant Congress abstracts (from 2012 through December 2017). Fourteen articles were reviewed that included case reports, retrospective case series, or chart review analyses of small cohorts...
September 16, 2018: Progress in Transplantation
Julia Torabi, Juan P Rocca, Krystina Choinski, Katherine A Lorenzen, Maria Ajaimy, Jay A Graham
No abstract text is available yet for this article.
September 13, 2018: Progress in Transplantation
Razan Alsheikh, Steven Gabardi
BACKGROUND: Previous studies reported improved outcomes for renal recipients undergoing early steroid withdrawal (ESW), with significantly lower rates of new-onset diabetes, cytomegalovirus (CMV), and malignancy. As renal transplants in older adults has increased, studies have shown similar outcomes between elderly and younger patients. We aim to evaluate post-renal transplantation outcomes in elderly patients compared to younger patients who have undergone ESW. METHODS: A retrospective analysis of adults who received transplants between January 2004 and December 2014 and received either basiliximab or antithymocyte globulin for induction, underwent ESW, and received tacrolimus and mycophenolate for maintenance...
September 13, 2018: Progress in Transplantation
Eliza W Beal, Dmitry Tumin, Lindsay Sobotka, Joseph D Tobias, Don Hayes, Timothy M Pawlik, Kenneth Washburn, Khalid Mumtaz, Lanla Conteh, Sylvester M Black
BACKGROUND: The Appalachian region is medically underserved and characterized by high morbidity and mortality. We investigated disparities among patients listed for liver transplantation (LT) in wait-list outcomes, according to residence in the Appalachian region. METHODS: Data on adult patients listed for LT were obtained from the United Network for Organ Sharing for July 2013 to December 2015. Wait-list outcomes were compared using cause-specific hazard models by region of residence (Appalachian vs non-Appalachian) among patients listed at centers serving Appalachia...
September 11, 2018: Progress in Transplantation
Annette Lennerling, Annika M Kisch, Anna Forsberg
INTRODUCTION: Understanding medical information and self-management ability is vital for good quality of life among transplant recipients. However, health literacy (HL) has never been investigated among lung transplant recipients. OBJECTIVE: This study investigated HL among Swedish lung transplant recipients 1 to 5 years after lung transplantation in relation to recovery, fatigue, adherence, cognitive function (CF), and relevant demographic variables. METHOD: This study was part of a cross-sectional, Swedish multicenter study 1 to 5 years post lung transplantation called Self-Management after Thoracic Transplantation...
September 11, 2018: Progress in Transplantation
Rebeca Khorzad, Enid Montague, Anna P Nannicelli, Donna M Woods, Daniela P Ladner, Alexandra Brown, Jane Louise Holl
BACKGROUND: In 2012, the Health Resources and Services Administration and the United Network for Organ Sharing launched the "Electronic Tracking and Transportation" (ETT) project, in response to "labeling and packaging issues" being a frequently reported safety incident. This article describes an improvement project conducted as part of this United Network for Organ Sharing project. METHODS: An interdisciplinary team conducted a Process Failure Modes and Effects Analysis, laboratory simulations of organ labeling during procurement, and a heuristic evaluation of a label software application to inform the design of TransNet, a system that uses barcode technology at the point of organ recovery...
September 2018: Progress in Transplantation
Sonali D Advani, Anoma Nellore, Giorgos Hadjivassiliou, Devin E Eckhoff, Donna Salzman, Daniel Lavie, Peter Pavlidakey, John W Baddley
Graft-versus-host disease (GvHD) is a rare but fatal complication after solid organ transplantation arising in 1% to 2% of cases. We report 2 cases of GvHD after orthotopic liver transplantation. Both patients had a history of hepatitis C virus (HCV) infection prior to transplantation. Both cases presented between 1 and 4 months after transplantation with rash, pancytopenia, and/or diarrhea. Our second case also developed oral and ocular manifestations after liver transplantation, which are more commonly described after stem cell transplantation...
September 2018: Progress in Transplantation
Wayne M Tsuang, Songhua Lin, Maryam Valapour, Belinda L Udeh, Marie Budev, Jesse D Schold
INTRODUCTION: Recipient travel distance may be an unrecognized burden in lung transplantation. DESIGN: Retrospective single-center cohort study of all adult (≥18 years) first-time lung-only transplants from January 1, 2010, until February 28, 2017. Recipient distance to transplant center was calculated using the linear distance from the recipient's home zip code to the Cleveland Clinic in Cleveland, Ohio. RESULTS: 569 recipients met inclusion criteria...
September 2018: Progress in Transplantation
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