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American Journal of Physiology. Renal Physiology

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https://www.readbyqxmd.com/read/28814439/stimulating-bioelectronic-medicine-discovery-for-urological-disorders
#1
Peregrine B Osborne
N/A?
August 16, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28814438/collecting-duct-prorenin-receptor-knockout-reduces-renal-function-increases-na-excretion-and-mitigates-renal-responses-in-angii-induced-hypertensive-mice
#2
Minolfa C Prieto, Virginia Reverte, Mykola Mamenko, Marta Kuczeriska, Luciana C Veiras, Carla B Rosales, Matthew McLellan, Oliver Gentile, V Behrana Jensen, Atsuhiro Ichihara, Alicia A McDonough, Oleh M Pochynyuk, Alexis A Gonzalez
Augmented intratubular angiotensin (ANG) II is a key determinant of enhanced distal Na+ reabsorption via activation of epithelial Na+ channels (ENaC) and other transporters, which leads to the development of high blood pressure (BP). In ANGII-induced hypertension, there is increased expression of the prorenin receptor (PRR) in the collecting duct (CD), which has been implicated in the stimulation of the sodium transporters and resultant hypertension. The impact of PRR deletion along the nephron on BP regulation and Na+ handling remains controversial...
August 16, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28814437/adaptive-responses-of-rat-descending-vasa-recta-to-ischemia
#3
Zhong Zhang, Kristie Payne, Thomas L Pallone
We tested whether rat descending vasa recta (DVR) undergo regulatory adaptions after the kidney is exposed to ischemia. Left kidneys (LK) were subjected to 30 minute renal artery cross clamp. After 48 hours, the post-ischemic LK and contralateral right kidney (RK) were harvested for study. When compared to DVR isolated from either sham operated LK or the contralateral RK, post-ischemic LK DVR markedly increased their NO generation. The selective inducible NOS (iNOS) inhibitor, 1400W, blocked the NO response...
August 16, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28794068/sex-and-rigor-the-tgf-%C3%AE-blood-pressure-affair
#4
Kathryn Sandberg, Amrita V Pai, Taylor Maddox
not relevant.
August 9, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28794067/sodium-intake-affects-gender-difference-in-aldosterone-concentration
#5
Kento Kitada, Akira Nishiyama
Editorial Focus - F-109-2017.
August 9, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28794066/insights-into-cellular-and-molecular-basis-for-urinary-tract-infection-in-autosomal-dominant-polycystic-kidney-disease
#6
Chao Gao, Long Zhang, Ye Zhang, Darren Paul Wallace, Reynold I Lopez-Soler, Paul J Higgins, Wenzheng Zhang
Urinary tract infection (UTI) is a broad term referring to an infection of the kidneys, ureters, bladder and/or urethra. Due to its prevalence, frequent recurrence and rising resistance to antibiotics, UTI has become a challenge in clinical practice. Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic disorder of the kidney and is characterized by the growth of fluid-filled cysts in both kidneys. Progressive cystic enlargement, inflammation and interstitial fibrosis result in nephron loss with subsequent decline in kidney function...
August 9, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28794065/vasa-recta-pericyte-density-is-negatively-associated-with-vascular-congestion-in-the-renal-medulla-following-ischemia-reperfusion-in-rats
#7
G Ryan Crislip, Paul M O'Connor, Qingqing Wei, Jennifer C Sullivan
Recent evidence suggests that a greater density of pericytes in renal cadaveric allografts is associated with better recovery following transplant. The physiological mechanism(s) through which pericyte density may be beneficial is not well understood. The goal of this study was to test the hypothesis that lower medullary pericyte density is associated with greater renal injury following ischemia reperfusion (IR) in a rat model, providing a basis for future studies to better understand pericytes in a pathological environment...
August 9, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28768667/trpv4-channels-contribute-to-renal-myogenic-autoregulation-in-neonatal-pigs
#8
Hitesh Soni, Dieniffer Peixoto-Neves, Anberitha T Matthews, Adebowale Adebiyi
Myogenic response, a phenomenon in which resistance size arteries and arterioles swiftly constrict or dilate in response to an acute elevation or reduction, respectively in intravascular pressure is a key component of renal autoregulation mechanisms. Although it is well-established that the renal system is functionally immature in neonates, mechanisms that regulate neonatal renal blood flow (RBF) remain poorly understood. In this study, we investigated the hypothesis that members of the transient receptor potential vanilloid (TRPV) channels are molecular components of renal myogenic constriction in newborns...
August 2, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28768666/oab-without-an-overactive-bladder-in-the-acute-prostaglandin-e2-rat-model
#9
James A Hokanson, Christopher L Langdale, Arun Sridhar, Warren M Grill
Intravesical Prostaglandin E2 (PGE2) was previously used to induce overactive bladder (OAB) symptoms as it reduces bladder capacity in rats and causes a "strong urgency sensation" in healthy women. However, the mechanism by which this occurs is unclear. To clarify how PGE2 reduces bladder capacity, 100 µM PGE2 was administered intravesically during open, single-fill cystometry with simultaneous measurement of sphincter EMG in the urethane-anesthetized female Wistar rat. PGE2 was also applied to the urethra or bladder selectively by use of a ligature at the bladder neck prior to (urethra) or during (bladder) closed-outlet, single-fill cystometry...
August 2, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28768665/dopamine-reduces-cell-surface-na-h-exchanger-3-nhe3-protein-by-decreasing-nhe3-exocytosis-and-cell-membrane-recycling
#10
Ming Chang Hu, Ion Alexandru Bobulescu, Henry Quiñones, Serge M Gisler, Orson W Moe
The intrarenal autocrine-paracrine dopamine (DA) system mediates a significant fraction of the natriuresis in response to a salt load. DA inhibits a number of Na+ transporters to effect sodium excretion, including the proximal tubule Na+/H+ exchanger-3 (NHE3). DA represent a single hormone that regulates NHE3 at multiple levels including translation, degradation, endocytosis, and protein phosphorylation. Since cell surface NHE3 protein is determined by the balance between exocytotic insertion and endocytotic retrieval, we examined whether DA acutely affects the rate of NHE3 exocytosis in a cell culture model...
August 2, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28768664/preventative-effects-of-a-hif-inhibitor-17-dmag-on-partial-bladder-outlet-obstruction-induced-bladder-dysfunction
#11
Nao Iguchi, M İrfan Dönmez, Anna P Malykhina, Alonso Carrasco, Duncan T Wilcox
Posterior urethral valves are the most common cause of partial bladder outlet obstruction (PBOO) in the pediatric population. Pathological changes in the bladder developed during PBOO are responsible for long-lasting voiding dysfunction in this population despite early surgical interventions. Increasing evidence showed PBOO induces an upregulation of Hypoxia inducible factors (HIFs) and their transcriptional target genes, and they play a role in pathophysiological changes in the obstructed bladders. We hypothesized that blocking HIF pathways can prevent PBOO-induced bladder dysfunction...
August 2, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28768663/effects-of-multiple-simulated-birth-traumas-on-urethral-continence-function-in-rats
#12
Satoru Yoshikawa, Yasuhiro Sumino, Joonbeom Kwon, Takahisa Suzuki, Takeya Kitta, Minoru Miyazato, Naoki Yoshimura
Multiple vaginal parities have been reported to be an important risk factor for stress urinary incontinence (SUI). Simulated birth trauma with single vaginal distention (VD) has been used to induce the SUI condition in animals; however, the effect of multiple simulated birth traumas on the urethral continence function has not been well characterized. Therefore, we examined the effects of multiple VDs on urethral functions in vivo and the changes in gene expressions of several molecules in the urethra using female SD rats, which were divided into 3 groups; sham, VD-1 (single VD), and VD-3 groups (3 times of VDs every 2 weeks)...
August 2, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28768662/stimulation-of-diuresis-and-natriuresis-by-renomedullary-infusion-of-a-dual-inhibitor-of-fatty-acid-amide-hydrolase-and-monoacylglycerol-lipase
#13
Ashfaq Ahmad, Zdravka Daneva, Guangbi Li, Sara K Dempsey, Ningjun Li, Justin Poklis, Aron Lichtman, Pin-Lan Li, Joseph Kraft Ritter
The renal medulla, considered critical for the regulation of salt and water balance and long-term blood pressure control, is enriched in anandamide and two of its major metabolizing enzymes, cyclooxygenase-2 (COX-2) and fatty acid amide hydrolase (FAAH). Infusion of anandamide (15, 30 and 60 nmol/min/kg) into the renal medulla of C57BL/6J mice stimulated diuresis and salt excretion in a COX-2- but not COX-1-dependent manner. To determine if endogenous endocannabinoids in the renal medulla can elicit similar effects, the effects of intramedullary isopropyl dodecyl fluorophosphate (IDFP), which inhibits the two major endocannabinoid hydrolases, were studied...
August 2, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28768661/all-trans-retinoic-acid-mediated-cytoprotection-in-renal-epithelial-cells-is-coupled-to-p-erk-activation-in-a-ros-independent-manner
#14
Jessica M Sapiro, Terrence J Monks, Serrine S Lau
Although all-trans-retinoic acid (ATRA) provides protection against a variety of conditions in vivo, particularly ischemia, the molecular mechanisms underpinning these effects remain unclear. The present studies were designed to assess potential mechanisms by which ATRA affords cytoprotection against renal toxicants in LLC-PK1 cells. Pretreatment of LLC-PK1 cells with ATRA (25 μM) for 24 hr afforded cytoprotection against oncotic cell death induced by p-aminophenol (PAP), 2-(glutathion-S-yl)hydroquinone (MGHQ), and iodoacetamide but not against apoptotic cell death induced by cisplatin...
August 2, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28747361/metabolic-acidosis-stimulates-the-production-of-the-antimicrobial-peptide-cathelicidin-in-rabbit-urine
#15
Hu Peng, Jeffrey M Purkerson, Andrew L Schwaderer, George J Schwartz
Intercalated cells of the collecting duct (CD) are critical for acid-base homeostasis and innate immune defense of the kidney. Little is known about the impact of acidosis on innate immune defense in the distal nephron. Urinary tract infections are mainly due to Escherichia coli and are an important risk factor for development of chronic kidney disease. While the effect of urinary pH on growth of E. coli is well established, in this study we demonstrate that acidosis increases urine antimicrobial activity due, at least in part, to induction of cathelicidin expression within the CD...
July 26, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28747360/cannabinoids-and-the-kidney-effects-in-health-and-disease
#16
Frank Park, Praveen K Potukuchi, Hamid Moradi, Csaba P Kovesdy
Consumption of cannabis and various related products (cannabinoids) for both medicinal and recreational use is gaining popularity. Furthermore, regulatory changes are fostering a cultural shift towards increasing liberalization of cannabis use, thereby increasing the likelihood of even larger numbers of individuals being exposed in the future. The two different types of receptors (CB1 and CB2) that are activated by the pharmacologically active ingredients of cannabis are found in numerous tissues, including the kidneys...
July 26, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28747359/coupling-between-phosphate-and-calcium-homeostasis-a-mathematical-model
#17
David Granjon, Olivier Bonny, Aurélie Edwards
We developed a mathematical model of calcium (Ca) and phosphate (PO4) homeostasis in the rat to elucidate the hormonal mechanisms that underlie the regulation of Ca and PO4 balance. The model represents the exchanges of Ca and PO4 between the intestine, plasma, kidneys, bone, and the intracellular compartment, and the formation of Ca-PO4-fetuin A complexes. It accounts for the regulation of these fluxes by parathyroid hormone (PTH), vitamin D3, fibroblast growth factor 23 (FGF23), and Ca2+-sensing receptors...
July 26, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28747358/urinary-renin-angiotensin-markers-in-polycystic-kidney-disease
#18
Mahdi Salih, Dominique M Bovee, Lodi C W Roksnoer, Niek F Casteleijn, Stephan J L Bakker, Ronald T Gansevoort, Robert Zietse, A H Jan Danser, Ewout J Hoorn
In autosomal dominant polycystic kidney disease (ADPKD) activation of the renin-angiotensin aldosterone system (RAAS) may contribute to hypertension and disease progression. Although previous studies focused on circulating RAAS-components, preliminary evidence suggests APDKD may increase urinary RAAS-components. Therefore, our aim was to analyze circulating and urinary RAAS-components in ADPKD. We cross-sectionally compared 60 patients with ADPKD to 57 patients with non-ADPKD chronic kidney disease (CKD). The two groups were matched by gender, estimated glomerular filtration rate (eGFR), blood pressure, and RAAS-inhibitor use...
July 26, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28747357/an-inhibitor-of-histone-deacetylase-6-activity-acy-1215-reduces-camp-and-cyst-growth-in-polycystic-kidney-disease
#19
Murali Krishna Yanda, Qiangni Liu, Liudmila Cebotaru
Adult-onset autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in either the PKD1 or PKD2 gene, leading to malfunction of their gene products, polycystin 1 or 2. Histone deacetylase 6 (HDAC6) expression and activity are increased in PKD1-mutant renal epithelial cells. Here we studied the effect of ACY-1215, a specific HDAC6 inhibitor, on cyst growth in ADPKD. Treatment with ACY-1215 slowed cyst growth in a mouse model of ADPKD that forms massive cysts within 3 weeks after knockout of polycystin 1 function...
July 26, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28724612/regulation-of-pdz-domain-containing-1-pdzk1-expression-by-hepatocyte-nuclear-factor-1-alpha-hnf1%C3%AE-in-human-kidney
#20
Katharina Prestin, Janine Hussner, Celio Ferreira, Isabell Seibert, Vivien Breitung, Uwe Zimmermann, Henriette Elisabeth Meyer Zu Schwabedissen
In the renal proximal tubule the secretion and reabsorption of glomerularly filtrated compounds is realized by a functional network of uptake and efflux transporters. The activity and localization of several transporters expressed at the apical tubular membrane is regulated by the membrane associated protein PDZ domain containing 1 (PDZK1). We aimed to characterize the transcriptional regulation of this modulator of renal transport. Coexpression analyses of PDZK1 and putative regulators were performed using human kidney samples...
July 19, 2017: American Journal of Physiology. Renal Physiology
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