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American Journal of Physiology. Regulatory, Integrative and Comparative Physiology

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https://www.readbyqxmd.com/read/28404583/acute-hypoxia-activates-neuroendocrine-but-not-pre-sympathetic-neurons-in-the-paraventricular-nucleus-of-the-hypothalamus-differential-role-of-nitric-oxide
#1
K Max Coldren, De-Pei Li, David D Kline, Eileen M Hasser, Cheryl M Heesch
Hypoxia results in decreased arterial PO2, arterial chemoreflex activation, and compensatory increases in breathing, sympathetic outflow, and neuroendocrine secretions, including increased secretion of vasopressin (AVP), corticotropin releasing hormone (CRH), adrenocorticotropin hormone (ACTH), and corticosterone. In addition to a brainstem pathway including the nucleus tractus solitarius (nTS) and the rostral ventrolateral medulla (RVLM), medullary pathways to the paraventricular nucleus of the hypothalamus (PVN) contribute to chemoreflex responses...
April 12, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28404582/histone-deacetylase-activity-modulates-exercise-induced-skeletal-muscle-plasticity-in-zebrafish-danio-rerio
#2
Alec Izaac Marcus Simmonds, Frank Seebacher
Aerobic exercise has a positive impact on animals by enhancing skeletal muscle function and locomotor performance. Responses of skeletal muscle to exercise involve changes in energy metabolism, calcium handling, and the composition of contractile protein isoforms, which together influence contractile properties. Histone deacetylases (HDAC) can cause short-term changes in gene expression, and may thereby mediate plasticity in contractile properties of skeletal muscle in response to exercise. The aim of this project was to determine (in zebrafish, Danio rerio) the traits that mediate inter-individual differences in sustained and sprint performance, and to determine whether inhibiting class I and II HDACs mediates exercise-induced changes in these traits...
April 12, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28404581/maternal-and-postnatal-high-fat-diet-consumption-programs-energy-balance-and-hypothalamic-melanocortin-signaling-in-nonhuman-primate-offspring
#3
Elinor L Sullivan, Heidi M Rivera, Cadence A True, Juliana G Franco, Karalee Baquero, Tyler A Dean, Jeanette C Valleau, Diana L Takahashi, Tim Frazee, Genevieve Hanna, Melissa A Kirigiti, Leigh Ann A Bauman, Kevin L Grove, Paul Kievit
Maternal high-fat diet (HFD) consumption during pregnancy decreased fetal body weight and impacted development of hypothalamic melanocortin neural circuitry in nonhuman primate offspring. We investigated whether these impairments during gestation persisted in juvenile offspring and examined the interaction between maternal and early postnatal HFD consumption. Adult dams consumed either a control diet (CTR, 15% calories from fat) or a high saturated-fat diet (HFD, 37% calories from fat) during pregnancy. Offspring were weaned onto a CTR or HFD at approximately 8 months of age...
April 12, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28404580/effects-of-face-head-and-whole-body-cooling-during-passive-heat-stress-on-human-somatosensory-processing
#4
Hiroki Nakata, Mari Namba, Ryusuke Kakigi, Manabu Shibasaki
We herein investigated the effects of face/head and whole body cooling during passive heat stress on human somatosensory processing recorded by somatosensory-evoked potentials (SEPs) at C4' and Fz electrodes. Fourteen healthy subjects received a median nerve stimulation at the left wrist. SEPs were recorded at normothermic baseline (Rest), when esophageal temperature had increased by ~1.2 °C (Heat stress: HS) during passive heating, face/head cooling during passive heating (face/head cooling: FHC), and after HS (whole body cooling: WBC)...
April 12, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28381457/a-novel-biomarker-associated-with-distress-in-humans-calcium-binding-protein-spermatid-specific-1-cabs1
#5
Thomas Ritz, David Rosenfield, Chris D St Laurent, Ana F Trueba, Chelsey A Werchan, Pia D Vogel, Richard J Auchus, Eduardo Reyes-Serratos, A Dean Befus
BACKGROUND: Calcium binding protein, spermatid specific 1 (CABS1) is expressed in human submandibular gland and has an anti-inflammatory motif similar to that in submandibular rat 1 (SMR1) in rats. Here we investigate CABS1 in human saliva and its association with psychological and physiological distress and inflammation in humans. METHOD: Volunteers participated across three studies: weekly baseline measures; a psychosocial speech and mental arithmetic stressor under evaluative threat; and during academic exam stress...
April 5, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28381456/muscle-mechanoreflex-activation-via-passive-calf-stretch-causes-renal-vasoconstriction-in-healthy-humans
#6
Rachel C Drew, Cheryl A Blaha, Michael D Herr, Ruda Cui, Lawrence I Sinoway
Reflex renal vasoconstriction occurs during exercise, and renal vasoconstriction in response to upper-limb muscle mechanoreflex activation has been documented. However, the renal vasoconstrictor response to muscle mechanoreflex activation originating from lower limbs, with and without local metabolite accumulation, has not been assessed. Eleven healthy young subjects (26 ± 1y; 5 men) underwent two trials involving 3-min passive calf muscle stretch (mechanoreflex) during 7.5-min lower-limb circulatory occlusion (CO)...
April 5, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28381455/2015-ludwig-lecture-abnormal-cardiovascular-responses-to-exercise-in-hypertension-contribution-of-neural-factors
#7
Jere Holloway Mitchell
During both dynamic (e.g. endurance) and static (e.g. strength) exercise there are exaggerated cardiovascular responses in hypertension. This includes greater increases in blood pressure, heart rate, and efferent sympathetic nerve activity than in normals. Two of the known neural factors which contribute to this abnormal cardiovascular response are the exercise pressor reflex (EPR) and functional sympatholysis. The EPR originates in contracting skeletal muscle and reflexly increases sympathetic efferent nerve activity to the heart and blood vessels as well as decreases parasympathetic efferent nerve activity to the heart...
April 5, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28381454/erythropoiesis-with-endurance-training-dynamics-and-mechanisms
#8
David Montero, Andreas Breenfeldt-Andersen, Laura Oberholzer, Thomas Haider, Jens Peter Goetze, Anne-Kristine Meinild-Lundby, Carsten Lundby
The purpose of the present study was to characterize the progression of red blood cell volume (RBCV) expansion and potential volumetric and endocrine regulators of erythropoiesis during endurance training (ET). Nine healthy untrained volunteers (age=27±4 years) underwent supervised ET consisting of 3-4 × 60 min cycle ergometry sessions per week for 8 weeks. Plasma volume (PV), RBCV and overnight fasting hematological markers were determined prior to and at weeks 2, 4 and 8 of ET. In addition, plasma erythropoietin (EPO), cortisol, copeptin and pro-atrial natriuretic peptide concentrations were measured during a 3-hour morning period at baseline and post-exercise at weeks 1 and 8...
April 5, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28356298/activation-of-cb1-receptors-by-2-arachidonoylglycerol-attenuates-vasoconstriction-induced-by-u46619-and-angiotensin-ii-in-human-and-rat-pulmonary-arteries
#9
Olga Karpińska, Marta Baranowska-Kuczko, Monika Kloza, Ewa Ambrożewicz, Tomasz Kozłowski, Irena Kasacka, Barbara Malinowska, Hanna Kozłowska
Recent evidence suggests that endocannabinoids acting via cannabinoid CB1 receptors may modulate vascular responses of various vasoconstrictors in the rodent systemic vasculature. The aim of the study was to investigate whether endocannabinoids modulate the contractile responses evoked by a thromboxane A2 analog (U46619), angiotensin II (Ang II), serotonin (5-HT) and phenylephrine which stimulate distinct Gq/11-protein coupled receptors (TP, AT1, 5-HT2 and α1-adrenergic) in isolated endothelium-intact human (hPAs) and rat pulmonary arteries (rPAs)...
March 29, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28356297/nitric-oxide-sensitive-guanylyl-cyclase-signaling-affects-co2-dependent-but-not-pressure-dependent-regulation-of-cerebral-blood-flow
#10
Shadi Jahshan, Lior Dayan, Giris Jacob
Cerebrovascular CO2 reactivity is affected by nitric oxide (NO). We tested the hypothesis that sildenafil selectively potentiates NO-cGMP signaling affects CO2 reactivity. Fourteen healthy males (34±2 years) were enrolled in the study. BP, ECG, velocity of cerebral blood flow (CBF, measured by TCD), end tidal CO2 (EtCO2) were assessed at baseline (CO2 ~ 39 mm Hg), during hyperventilation (CO2 ~ 24 mm Hg), hypercapnia (CO2 ~ 46 mm Hg), boluses of phenylephrine (25-200 µg) and during graded head-up tilting (HUT)...
March 29, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28356296/sex-dependent-effects-of-antenatal-glucocorticoids-on-insulin-sensitivity-in-adult-sheep-role-of-the-adipose-tissue-renin-angiotensin-system
#11
G Angela Massmann, Jie Zhang, Won Joon Seong, Minhyoung Kim, Jorge P Figueroa
Exposure to glucocorticoids in utero is associated with changes in organ function and structure in the adult. The aims of this study were to characterize the effects of antenatal exposure to glucocorticoids on glucose handling and the role of adipose tissue. Pregnant sheep received betamethasone (Beta, 0.17 mg/kg) or vehicle (V) 24-h apart at 80-days gestation and allowed to deliver at term. At 9 months, male and female offspring were fed at either 100% of nutritional allowance (lean) or ad libitum for 3 months (obese)...
March 29, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28356295/the-role-of-leptin-in-energy-expenditure-the-hypothalamic-perspective
#12
Rahul Pandit, Sanne Beerens, Roger Ah Adan
The adipocyte derived hormone leptin is a peripheral signal that informs the brain about the metabolic status of an organism. Although traditionally viewed as an appetite suppressing hormone, studies in the past decade have highlighted the role of leptin in energy expenditure. Leptin has been shown to increase energy expenditure in particular through its effects on the cardiovascular system and brown adipose tissue (BAT) thermogenesis via the hypothalamus. The current review summarizes the role of leptin signaling in various hypothalamic nuclei and its effects on the sympathetic nervous system to influence blood pressure, heart rate and brown adipose tissue thermogenesis...
March 29, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28356294/exocytosis-proteins-as-novel-targets-for-diabetes-prevention-and-or-remediation
#13
Arianne Aslamy, Debbie C Thurmond
Diabetes remains one of the leading causes of morbidity and mortality worldwide, affecting an estimated 422 million adults. In the U.S. it is predicted that 1 in every 3 children born as of 2000 will suffer from diabetes in their lifetime. Type 2 diabetes results from combinatorial defects in pancreatic beta cell glucose-stimulated insulin secretion and in peripheral glucose uptake. Both processes, insulin secretion and glucose uptake, are mediated by exocytosis proteins, SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complexes, Sec1/Munc18 (SM), and Double C2-domain protein B (DOC2B)...
March 29, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28330968/examination-of-carnitine-palmitoyl-transferase-1-abundance-in-white-adipose-tissue-implications-in-obesity-research
#14
Jaycob D Warfel, Bolormaa Vandanmagsar, Olga S Dubuisson, Sydney M Hodgeson, Carrie M Elks, Eric Ravussin, Randall L Mynatt
Carnitine Palmitoyltransferase 1 (CPT1) is essential for the transport of long chain fatty acids into the mitochondria for oxidation. Recently, it was reported that decreased CPT1b mRNA in adipose tissue was a contributing factor for obesity in rats. We therefore closely examined the expression level of Cpt1 in adipose tissue from mice, rats, and humans. Cpt1a is the predominate isoform in adipose tissue from all three species. Rat white adipose tissue has a moderate amount of Cpt1b mRNA, but it is very minor compared to Cpt1b expression in muscle...
March 22, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28330967/muscle-sympathetic-nerve-activity-response-to-heat-stress-is-attenuated-in-chronic-heart-failure-patients
#15
Jian Cui, John Boehmer, Cheryl A Blaha, Lawrence I Sinoway
Heat stress evokes significant increases in muscle sympathetic nerve activity (MSNA) in healthy individuals. The MSNA response to heat stress in chronic heart failure (CHF) is unknown. We hypothesized that the MSNA response to heat stress is attenuated in CHF. Passive whole body heating was applied with water-perfused suits on 13 patients (61 ± 2 years) with stable class II-III CHF, 12 age-matched (62 ± 2 years) healthy subjects, and 14 young (24 ± 1 years) healthy subjects. Mild heating (i.e. increases in skin temperature ΔTsk ~2-4 °C, internal temperature ΔTcore <0...
March 22, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28330966/the-normal-increase-in-insulin-after-a-meal-may-be-required-to-prevent-postprandial-renal-sodium-and-volume-losses
#16
Debra L Irsik, Bonnie L Blazer-Yost, Alexander Staruschenko, Michael W Brands
Despite the effects of insulinopenia in type 1 diabetes and evidence that insulin stimulates multiple renal sodium transporters, it is not known whether normal variation in plasma insulin regulates sodium homeostasis physiologically. This study tested whether the normal postprandial increase in plasma insulin significantly attenuates renal sodium and volume losses. Rats were instrumented with chronic artery and vein catheters, housed in metabolic cages, and connected to hydraulic swivels. Measurements of urine volume and sodium excretion (UNaV) over 24 hrs and the 4-hr postprandial period were made in Control (C) rats and Insulin-Clamped (IC) rats in which the postprandial increase in insulin was prevented...
March 22, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28330965/greater-sympathoadrenal-activation-with-longer-pre-ventilation-intervals-after-immediate-cord-clamping-increases-hemodynamic-lability-at-birth-in-preterm-lambs
#17
Joseph J Smolich, Kelly R Kenna, Murray David Esler, Sarah E Phillips, Gavin W Lambert
This study tested the hypothesis that varying degrees of hemodynamic fluctuations seen after birth following immediate cord clamping were related to development of asphyxia with longer cord clamp-to-ventilation intervals, resulting in higher perinatal circulating levels of the catecholamines norepinephrine (NE) and epinephrine (Epi), and thus increased heart rate, blood pressures and cardiac contractility after birth. Anesthetized preterm fetal lambs were instrumented with 1) aortic (AoT) and pulmonary trunk (PT) micromanometers to obtain pressures and the maximal rate of pressure rise (dP/dtmax) as a surrogate measure of ventricular contractility, and 2) an AoT catheter to obtain samples for blood gas and catecholamine analyses...
March 22, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28330964/thermoregulatory-inversion-a-novel-thermoregulatory-paradigm
#18
Domenico Tupone, Georgina Cano, Shaun F Morrison
To maintain core body temperature in mammals, the normal CNS thermoregulatory reflex networks produce an increase in brown adipose tissue (BAT) thermogenesis in response to skin cooling, and an inhibition of the sympathetic outflow to BAT during skin rewarming. In contrast, these normal thermoregulatory reflexes appear to be inverted in hibernation/torpor: thermogenesis is inhibited during exposure to a cold environment, allowing dramatic reductions in core temperature and metabolism, and thermogenesis is activated during skin rewarming, contributing to a return of normal body temperature...
March 22, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28298332/impact-of-lifelong-exercise-training-on-endothelial-ischemia-reperfusion-and-ischemic-preconditioning-in-humans
#19
Martijn F H Maessen, Anke Ccm van Mil, Yaïra Straathof, Niels P Riksen, Gerard A P J M Rongen, Maria T E Hopman, Thijs M H Eijsvogels, Dick H J Thijssen
Reperfusion is essential for ischemic tissue survival, but causes additional damage to the endothelium (i.e. ischemia-reperfusion [IR] injury). Ischemic preconditioning (IPC) refers to short repetitive episodes of ischemia that can protect against IR. However, IPC efficacy attenuates with older age. Whether physical inactivity contributes to the attenuated efficacy of IPC to protect against IR injury in older humans is unclear. We tested the hypotheses that lifelong exercise training relates to 1) attenuated endothelial IR and 2) maintained IPC efficacy that protects veteran athletes against endothelial IR...
March 15, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28298331/expression-of-leptin-receptor-in-the-oviduct-of-chinese-brown-frog-rana-dybowskii
#20
Liqin Xi, Yuning Liu, Zeqi Tang, Xia Sheng, Haolin Zhang, Qiang Weng, Meiyu Xu
The oviduct of Chinese brown frog (Rana dybowskii) expands specifically during pre-hibernation instead of in the breeding period. In this study, we investigated the expression of leptin receptor (Ob-Rb) in Rana dybowskii oviduct during the breeding period and pre-hibernation. Histologically, the oviduct of Rana dybowskii consists of glandular cells, tubule lumen and epithelial cells. The oviductal weight and pipe diameter also revealed significant differences, which were higher in pre-hibernation than that of the breeding period...
March 15, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
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