Hao Huang, Jingshu Zeng, Xinyue Yu, Han Du, Chaojuan Wen, Yan Mao, Han Tang, Xielan Kuang, Wei Liu, Huan Yu, Huijun Liu, Bowen Li, Chongde Long, Jianhua Yan, Huangxuan Shen
Age-related macular degeneration (AMD) is characterized by the degenerative senescence in the retinal pigment epithelium (RPE) and photoreceptors, which is accompanied by the accumulation of iron ions in the aging retina. However, current models of acute oxidative stress are still insufficient to simulate the gradual progression of AMD. To address this, we established chronic injury models by exposing the aRPE-19 cells, 661W cells, and mouse retina to iron ion overload over time. Investigations at the levels of cell biology and molecular biology were performed...
February 26, 2024: American Journal of Physiology. Cell Physiology