journal
Journals American Journal of Physiology...

American Journal of Physiology. Cell Physiology

https://read.qxmd.com/read/38525543/intracellular-zn-2-promotes-extracellular-matrix-remodeling-in-dexamethasone-treated-trabecular-meshwork
#1
JOURNAL ARTICLE
Canying Liu, Jiahui Tang, Yuze Chen, Qi Zhang, Jicheng Lin, Siting Wu, Jiaxu Han, Zhe Liu, Caiqing Wu, Yehong Zhuo, Yiqing Li
Given the widespread application of glucocorticoids in ophthalmology, the associated elevation of intraocular pressure (IOP) has long been a vexing concern for clinicians, yet the underlying mechanisms remain inconclusive. Much of the discussion focuses on the extracellular matrix (ECM) of trabecular meshwork (TM). It's widely agreed that glucocorticoids impact the expression of Matrix metalloproteinases (MMPs), leading to ECM deposition. Since Zn2+ is vital for MMPs, we explored its role in ECM alterations induced by dexamethasone (DEX)...
March 25, 2024: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/38525542/apelin-regulates-skeletal-muscle-adaptation-to-exercise-in-a-high-intensity-interval-training-hiit-model
#2
JOURNAL ARTICLE
Teemu Kilpiö, Sini Skarp, Abel Perjes, Julia Swan, Leena Kaikkonen, Samu Saarimaki, Istvan Szokodi, Josef M Penninger, Zoltan Szabo, Johanna Magga, Risto Kerkela
Plasma apelin levels are reduced in aging and muscle wasting conditions. We aimed to investigate the significance of apelin signaling in cardiac and skeletal muscle responses to physiological stress. Apelin knockout (KO) and wild type (WT) mice were subjected to high intensity interval training (HIIT) by treadmill running. The effects of apelin on energy metabolism were studied in primary mouse skeletal muscle myotubes and cardiomyocytes. Apelin increased mitochondrial ATP production and mitochondrial coupling efficiency in myotubes and promoted the expression of mitochondrial genes both in primary myotubes and cardiomyocytes...
March 25, 2024: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/38525541/adipose-transplantation-improves-metabolism-and-atherosclerosis-but-not-pvat-abnormality-or-vascular-dysfunction-in-lipodystrophic-seipin-apoe-null-mice
#3
JOURNAL ARTICLE
Zhe Meng, Chuangxing Liu, Mengke Xu, Yongqiang Tao, Haiyu Li, Xijia Wang, Jiawei Liao, Mengyu Wang
Adipose dysfunction in lipodystrophic SEIPIN deficiency is associated with multiple metabolic disorders and increased risks of developing cardiovascular diseases, such as atherosclerosis, cardiac hypertrophy, and heart failure. Recently, adipose transplantation is found to correct adipose dysfunction and metabolic disorders in lipodystrophic Seipin knockout mice; however, whether adipose transplantation could improve lipodystrophy-associated cardiovascular consequences is still unclear. Here, we aimed to explore the effects of adipose transplantation on lipodystrophy-associated metabolic cardiovascular diseases in Seipin knockout mice crossed into atherosclerosis-prone apolipoprotein E ( Apoe ) knockout background...
March 25, 2024: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/38525540/the-role-of-nano-systems-in-the-delivery-of-glucose-lowering-drugs-for-the-pre-emption-and-treatment-of-diabetes-associated-atherosclerosis
#4
REVIEW
Luke James Conroy, Alyssa McCann, Nan Zhang, Monica de Gaetano
Diabetes is one of the most prevalent diseases worldwide. In recent decades, type-2 diabetes has become increasingly common, particularly in younger individuals. Diabetes leads to many vascular complications, including atherosclerosis. Atherosclerosis is a cardiovascular disease characterized by lipid-rich plaques within the vasculature. Plaques develop over time, restricting blood flow; and can therefore be the underlying cause of major adverse cardiovascular events, including myocardial infarction and stroke...
March 25, 2024: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/38525539/regulation-of-renal-aquaporin-water-channels-in-acute-pyelonephritis
#5
JOURNAL ARTICLE
Christina V Ernstsen, Marianna Ranieri, Frédéric H Login, Isra K Mahmoud, Jacob R Therkildsen, Giovanna Valenti, Helle Praetorius, Rikke Nørregaard, Lene N Nejsum
Acute pyelonephritis (APN) is most frequently caused by uropathogenic Escherichia coli (UPEC), which ascends from the bladder to the kidneys during a urinary tract infection. Patients with APN have been reported to have reduced renal concentration capacity under challenged conditions, polyuria and increased aquaporin-2 (AQP2) excretion in the urine. We have recently shown increased AQP2 accumulation in the plasma membrane in cell cultures exposed to E. coli lysates and in the apical plasma membrane of inner medullary collecting ducts in a 5-day APN mouse model...
March 25, 2024: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/38525538/advances-in-gpcrs-structure-mechanisms-disease-and-pharmacology
#6
EDITORIAL
Zeyu Cai, Wei Kong
No abstract text is available yet for this article.
March 25, 2024: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/38525537/substance-p-promotes-tgf-%C3%AE-induced-collagen-synthesis-in-human-corneal-fibroblasts
#7
JOURNAL ARTICLE
Koji Sugioka, Teruo Nishida, Junko Murakami, Motoki Itahashi, Mai Yunoki, Shunji Kusaka
Corneal fibroblasts maintain homeostasis of the corneal stroma by mediating the synthesis and degradation of extracellular collagen, and these actions are promoted by transforming growth factor-β (TGF-β) and interleukin-1b (IL-1β), respectively. The cornea is densely innervated with sensory nerve fibers that are not only responsible for sensation but also required for physiological processes such as tear secretion and wound healing. Loss or dysfunction of corneal nerves thus impairs corneal epithelial wound healing and can lead to neurotrophic keratopathy...
March 25, 2024: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/38497114/the-myokine-ccl5-recruits-subcutaneous-preadipocytes-and-promotes-intramuscular-fat-deposition-in-obese-mice
#8
JOURNAL ARTICLE
Wensai Yu, Yao Yao, Nanwei Ye, Yuelei Zhao, Zijian Ye, Wei Wei, Lifan Zhang, Jie Chen
Intramuscular fat (IMF) refers to the lipid stored in skeletal muscle tissue. The number and size of intramuscular adipocytes are the primary factors that regulate IMF content. Intramuscular adipocytes can be derived from either in situ or ectopic migration. In this study, it was discovered that the regulation of IMF levels is achieved through the chemokine (C-C motif) ligand 5 (CCL5)/chemokine (C-C motif) receptor 5 (CCR5) pathway by modulating adipocyte migration. In coculture experiments, C2C12 myotubes were more effective in promoting the migration of 3T3-L1 preadipocytes than C2C12 myoblasts, along with increasing CCL5...
March 18, 2024: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/38497113/kynurenine-3-monooxygenase-kmo-limits-de-novo-nad-synthesis-through-dietary-tryptophan-in-renal-proximal-tubule-epithelial-cell-models
#9
JOURNAL ARTICLE
Yougang Zhai, Jose A Chavez, Katharine E D'Aquino, Rong Meng, Andrea R Nawrocki, Alessandro Pocai, Lifeng Wang, Li-Jun Ma
Nicotinamide adenine dinucleotide (NAD+ ) is a pivotal coenzyme, essential for cellular reactions, metabolism, and mitochondrial function. Depletion of kidney NAD+ levels and reduced de novo NAD+ synthesis through the tryptophan-kynurenine pathway are linked to acute kidney injury (AKI), while augmenting NAD+ shows promise in reducing AKI. We investigated de novo NAD+ biosynthesis using in vitro, ex vivo and in vivo models to understand its role in AKI. 2D cultures of human primary renal proximal tubule epithelial cells (RPTECs) and HK-2 cells showed limited de novo NAD+ synthesis, likely due to low pathway enzyme gene expression...
March 18, 2024: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/38497112/roles-for-integrin-%C3%AE-3%C3%AE-1-in-regulating-the-ability-of-epithelial-cells-to-modulate-the-microenvironment-during-normal-and-pathological-tissue-remodeling
#10
REVIEW
Rakshitha Pandulal Miskin, C Michael DiPersio
Integrin receptors for the extracellular matrix activate intracellular signaling pathways that are critical for tissue development, homeostasis, and regeneration/repair, and their loss or dysregulation contributes to many developmental defects and tissue pathologies. This review will focus on tissue remodeling roles for integrin α3β1, a receptor for laminins found in the basement membranes that underlie epithelial cell layers. As a paradigm, we will discuss literature that supports a role for α3β1 in promoting ability of epidermal keratinocytes to modify their tissue microenvironment during skin development, wound healing or tumorigenesis...
March 18, 2024: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/38497111/a-novel-approach-to-determine-the-critical-survival-threshold-of-cellular-oxygen-within-spheroids-via-integrating-live-dead-cell-imaging-with-oxygen-modeling
#11
JOURNAL ARTICLE
Kuang-Ming Shang, Hiroyuki Kato, Nelson Gonzalez, Fouad Kandeel, Yu-Chong Tai, Hirotake Komatsu
Hypoxia plays a crucial role in cell physiology. Defining the oxygen level that induces cell death within 3D tissues is vital for understanding tissue hypoxia; however, obtaining accurate measurements has been technically challenging. In this study, we introduce a non-invasive, high-throughput methodology to quantify critical survival partial oxygen pressure (pO₂) with high spatial resolution within spheroids by employing a combination of controlled hypoxic conditions, semi-automated live/dead cell imaging, and computational oxygen modeling...
March 18, 2024: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/38497110/timp2-protects-against-sepsis-associated-acute-kidney-injury-by-camp-nlrp3-axis-mediated-pyroptosis
#12
JOURNAL ARTICLE
Dongxue Xu, Jun Jiang, Ye Liu, Jingjing Pang, Jinmeng Suo, Yiming Li, Zhiyong Peng
The tissue inhibitor of metalloproteinases 2 (TIMP2) has emerged as a promising biomarker for predicting the risk of sepsis-associated acute kidney injury (SA-AKI). However, its exact role in SA-AKI and the underlying mechanism remains unclear. In this study, we investigated the impact of kidney tubule-specific Timp2 knockout mice on kidney injury and inflammation. Our findings demonstrated that Timp2-knockout mice exhibited more severe kidney injury than wild-type mice, along with elevated levels of pyroptosis markers NLRP3, Caspase1, and GSDMD in the early stage of SA-AKI...
March 18, 2024: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/38406827/cannabidiol-protects-c2c12-myotubes-against-cisplatin-induced-atrophy-by-regulating-oxidative-stress
#13
JOURNAL ARTICLE
Olivier Le Bacquer, Phelipe Sanchez, Véronique Patrac, César Rivoirad, Nicolas Saroul, Christophe Giraudet, Ayhan Kocer, Stephane Walrand
Cancer and chemotherapy can both cause cachexia, a complex multi-organ syndrome characterized by body weight loss, due to adipose tissue and skeletal muscle wasting. Changes in body weight and muscle mass are predictive of response to chemotherapy, incidence of treatment-related complications and, ultimately, patient survival, but there are currently still no clear therapeutic strategies to counteract cachexia. Cannabidiol (CBD) is a bioactive phytocannabinoid produced from a plant named Cannabis sativa . In recent years, CBD has demonstrated beneficial effects on maintaining skeletal muscle mass, function and metabolism in models of muscular dystrophy or diet-induced obesity...
February 26, 2024: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/38406826/establishing-chronic-models-of-age-related-macular-degeneration-via-long-term-iron-ion-overload
#14
JOURNAL ARTICLE
Hao Huang, Jingshu Zeng, Xinyue Yu, Han Du, Chaojuan Wen, Yan Mao, Han Tang, Xielan Kuang, Wei Liu, Huan Yu, Huijun Liu, Bowen Li, Chongde Long, Jianhua Yan, Huangxuan Shen
Age-related macular degeneration (AMD) is characterized by the degenerative senescence in the retinal pigment epithelium (RPE) and photoreceptors, which is accompanied by the accumulation of iron ions in the aging retina. However, current models of acute oxidative stress are still insufficient to simulate the gradual progression of AMD. To address this, we established chronic injury models by exposing the aRPE-19 cells, 661W cells, and mouse retina to iron ion overload over time. Investigations at the levels of cell biology and molecular biology were performed...
February 26, 2024: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/38406825/normal-vision-and-development-in-mice-with-low-functional-expression-of-kir7-1-in-heterozygosis-for-a-blindness-producing-mutation-inactivating-the-channel
#15
JOURNAL ARTICLE
Erwin Vera, Isabel Cornejo, Juan Carlos Henao, Felipe Tribiños, Johanna Burgos, Francisco V Sepulveda, L Pablo Cid
K+ channel Kir7.1 expressed at the apical membrane of the retinal pigment epithelium (RPE) plays an essential role in retinal function. An isoleucine-to-threonine mutation at position 120 of the protein is responsible for blindness-causing vitreo-retinal dystrophy. We have studied the molecular mechanism of action of Kir7.1-I120T in vitro by heterologous expression and in vivo by in CRISPR-generated knockin mice. Full-size Kir7.1-I120T reaches the plasma membrane but lacks any activity. Analysis of Kir7.1 and the I120T mutant in mixed transfection experiments, and that of tandem tetrameric constructs made by combining WT and mutant protomers, leads us to conclude that they do not form heterotetramers in vitro ...
February 26, 2024: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/38406824/implications-of-ifn%C3%AE-snp-rs2069705-in-primary-sj%C3%A3-gren-s-syndrome-transcriptional-activation-and-b-cell-infiltration
#16
JOURNAL ARTICLE
Xi Chen, Min Li, Honglin Li, Miao Liu, Jianrong Su, Yuzhu Ji
OBJECTIVE: Primary Sjögren's Syndrome (pSS) is characterized by its autoimmune nature. This study investigates the role of the IFNγ SNP rs2069705 in modulating the susceptibility to pSS. METHODS: Differential expression of IFNγ and BAFF was analyzed using the GEO database's mRNA microarray GSE84844. Genotyping of the IFNγ SNP rs2069705 was conducted via the dbSNP website. The JASPAR tool was used for predicting transcription factor bindings...
February 26, 2024: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/38372137/modulation-of-prostaglandin-transport-activity-of-slco2a1-by-annexin-a2-and-s100a10
#17
JOURNAL ARTICLE
Yoshinobu Nakamura, Masa-Aki Ito, Yukino Hoshino, Isao Matsuoka, Toshiaki Okada, Yasunobu Okada, Takeo Nakanishi
Solute carrier organic anion transporter family member 2A1 (SLCO2A1) is a prostaglandin (PG) transporter and serves as the osmosensitive ATP-permeable maxi-anion channel (Maxi-Cl). Since a heterotetrameric complex of annexin A2 (ANXA2) and S100A10 is obligatory for the channel activity; the present study aimed to determine if they regulate SLCO2A1-mediated PG transport. This study examined PGE2 uptake and ATP release in Anxa2 and/or S100a10 knockout (KO) murine breast C127 cells. Deletion of Slco2a1 decreased PGE2 -d4 uptake by wild-type (WT) cells in isotonic medium (290 mOsm/kg H2 O)...
February 19, 2024: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/38372136/the-role-of-fibronectin-in-mediating-cell-migration
#18
REVIEW
Jessica H Longstreth, Karin Wang
Fibronectin (FN) is a major extracellular matrix protein involved in a wide range of physiological processes, including cell migration. These fibronectin mediated cell migration events are essential to processes such as wound repair, cancer metastasis, and vertebrate development. This review synthesizes mainly current literature to provide an overview of the mechanoregulatory role of FN-mediated cell migration. Background on FN structure and role in mechanotransduction is provided. Cell migration concepts are introduced, including the general cell migration mechanism and classification of cell migration types...
February 19, 2024: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/38344800/depalmitoylation-and-cell-physiology-apt1-as-a-mediator-of-metabolic-signals
#19
REVIEW
Sarah L Speck, Xiaochao Wei, Clay F Semenkovich
More than half of the global population is obese or overweight, especially in Western countries, and this excess adiposity disrupts normal physiology to cause chronic diseases. Diabetes, an adiposity-associated epidemic disease, affects more than 500 million people and cases are projected to exceed one billion before 2050. Lipid excess can impact physiology through the post-translational modification of proteins, including the reversible process of S-palmitoylation. Dynamic palmitoylation cycling requires the S-acylation of proteins by acyltransferases and the depalmitoylation of these proteins mediated in part by acyl-protein thioesterases (APTs) such as APT1...
February 12, 2024: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/38344799/characterizing-the-effects-of-muscle-specific-gsk3a-b-reduction-on-murine-muscle-contractility-and-metabolism-in-female-mice
#20
JOURNAL ARTICLE
Briana L Hockey, Michael S Finch, Jessica L Braun, Ahmad Mohammad, Lucas A Maddalena, Rene Vandenboom, Jeffrey A Stuart, Brian D Roy, Rebecca E K MacPherson, Val A Fajardo
Dysregulation of skeletal muscle morphology and metabolism is associated with chronic diseases such as obesity and type 2 diabetes. The enzyme glycogen synthase kinase 3 (GSK3) is highly involved in skeletal muscle physiology and metabolism, acting as a negative regulator of muscle size, strength, adaptive thermogenesis, and glucose homeostasis. Correspondingly, we have shown that partial gene expression knockdown (~40%) of gsk3 specifically in skeletal muscle increases lean mass, reduces fat mass, and activates muscle-based adaptive thermogenesis via sarco(endo)plasmic reticulum Ca2+ (SERCA) uncoupling in male mice...
February 12, 2024: American Journal of Physiology. Cell Physiology
journal
journal
34858
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.